Symbol	Name	Description	Biological process	Cellular component	Molecular function	LocusLink ID	Other Aliases
Ensembl Gene ID	Associated Gene Name	Description					
Q0010	Q0010	Dubious mitochondrial open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF Q0017 [Source:SGD;Acc:S000007257]					
Q0017	Q0017	Dubious mitochondrial open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF Q0010 [Source:SGD;Acc:S000007258]					
Q0032	Q0032	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007259]					
Q0045	COX1	Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits [Source:SGD;Acc:S000007260]	aerobic respiration, electron transport chain, mitochondrial electron transport, cytochrome c to oxygen, oxidation-reduction process, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion, respiratory chain	cytochrome-c oxidase activity, electron carrier activity, heme binding, iron ion binding, metal ion binding, oxidoreductase activity		
Q0050	AI1	Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene [Source:SGD;Acc:S000007261]	RNA splicing, RNA-dependent DNA replication, aerobic respiration, cellular respiration, homing of group II introns, mRNA processing	integral to membrane, mitochondrion	RNA binding, RNA-directed DNA polymerase activity, electron carrier activity, endonuclease activity, heme binding, iron ion binding, nucleic acid binding		
Q0055	AI2	Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene [Source:SGD;Acc:S000007262]	RNA splicing, RNA-dependent DNA replication, aerobic respiration	integral to membrane, mitochondrion	RNA binding, RNA-directed DNA polymerase activity, electron carrier activity, endonuclease activity, heme binding, iron ion binding, nucleic acid binding		
Q0060	AI3	Endonuclease I-SceIII, encoded by a mobile group I intron within the mitochondrial COX1 gene [Source:SGD;Acc:S000007263]	RNA splicing, aerobic respiration, biological_process, intron homing, mRNA processing	integral to membrane, membrane, mitochondrion	DNA binding, electron carrier activity, endonuclease activity, heme binding, hydrolase activity, iron ion binding, nuclease activity		
Q0065	AI4	Endonuclease I-SceII, encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity [Source:SGD;Acc:S000007264]	RNA splicing, aerobic respiration, intron homing, mRNA processing	integral to membrane, mitochondrion	DNA binding, electron carrier activity, endonuclease activity, heme binding, hydrolase activity, iron ion binding, nuclease activity		
Q0070	AI5_ALPHA	Endonuclease I-SceIV, involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene [Source:SGD;Acc:S000007265]	RNA splicing, aerobic respiration, intron homing, mRNA processing, movement of group I intron	integral to membrane, membrane, mitochondrion	electron carrier activity, endonuclease activity, heme binding, hydrolase activity, iron ion binding, nuclease activity		
Q0075	AI5_BETA	Protein of unknown function, encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG [Source:SGD;Acc:S000007266]	aerobic respiration, biological_process, intron homing	integral to membrane, mitochondrion	DNA binding, electron carrier activity, endonuclease activity, heme binding, hydrolase activity, iron ion binding, molecular_function, nuclease activity		
Q0080	ATP8	Subunit 8 of the F0 sector of mitochondrial inner membrane F1-F0 ATP synthase, encoded on the mitochondrial genome; ATP8 and ATP6 mRNAs are not translated in the absence of the F1 sector of ATPase [Source:SGD;Acc:S000007267]	ATP biosynthetic process, ATP synthesis coupled proton transport, ion transport, proton transport, transport	integral to membrane, membrane, mitochondrial membrane, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrion, proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism		
Q0085	ATP6	Mitochondrially encoded subunit a of the F0 sector of mitochondrial F1F0 ATP synthase; translation is specifically activated by Atp22p; ATP6 and ATP8 mRNAs are not translated in the absence of the F1 sector of ATPase [Source:SGD;Acc:S000007268]	ATP biosynthetic process, ATP synthesis coupled proton transport, ion transport, proton transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrion, proton-transporting ATP synthase complex, coupling factor F(o)	ATPase activity, hydrogen ion transmembrane transporter activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism		
Q0092	Q0092	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007269]					
Q0105	COB	Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p [Source:SGD;Acc:S000007270]	aerobic respiration, electron transport chain, mitochondrial electron transport, ubiquinol to cytochrome c, respiratory electron transport chain, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex III, mitochondrion, respiratory chain	electron carrier activity, electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity, metal ion binding, oxidoreductase activity, ubiquinol-cytochrome-c reductase activity		
Q0110	BI2	Mitochondrial mRNA maturase with a role in splicing, encoded by both exon and intron sequences of partially processed COB mRNA [Source:SGD;Acc:S000007271]	RNA splicing, mRNA processing, respiratory electron transport chain	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	electron carrier activity, endonuclease activity, nuclease activity, oxidoreductase activity		
Q0115	BI3	Mitochondrial mRNA maturase, forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA [Source:SGD;Acc:S000007272]	Group I intron splicing, RNA splicing, intron homing, mRNA processing, respiratory electron transport chain	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	DNA binding, RNA binding, electron carrier activity, endonuclease activity, oxidoreductase activity		
Q0120	BI4	Mitochondrial mRNA maturase, forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA [Source:SGD;Acc:S000007273]	Group I intron splicing, RNA splicing, intron homing, mRNA processing, respiratory electron transport chain	membrane, mitochondrion	DNA binding, RNA binding, electron carrier activity, endonuclease activity, oxidoreductase activity		
Q0130	OLI1	F0-ATP synthase subunit c (ATPase-associated proteolipid), encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2 [Source:SGD;Acc:S000007274]	ATP hydrolysis coupled proton transport, ATP synthesis coupled proton transport, ion transport, proton transport, transport	integral to membrane, membrane, mitochondrial membrane, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrion, proton-transporting ATP synthase complex, coupling factor F(o), proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase activity, hydrogen ion transmembrane transporter activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, lipid binding, proton-transporting ATPase activity, rotational mechanism		
Q0140	VAR1	Mitochondrial ribosomal protein of the small subunit, mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane [Source:SGD;Acc:S000007275]	mitochondrial translation, translation	mitochondrial ribosome, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
Q0142	Q0142	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious open reading frame Q0143 [Source:SGD;Acc:S000007276]					
Q0143	Q0143	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007277]					
Q0144	Q0144	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007278]					
Q0160	SCEI	I-SceI DNA endonuclease, encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene [Source:SGD;Acc:S000007279]	RNA splicing, intron homing, mRNA processing, respiratory electron transport chain	membrane, mitochondrion	endonuclease activity, hydrolase activity, nuclease activity		
Q0182	Q0182	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007280]					
Q0250	COX2	Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits [Source:SGD;Acc:S000007281]	aerobic respiration, electron transport chain, mitochondrial electron transport, cytochrome c to oxygen, oxidation-reduction process, respiratory electron transport chain, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion, respiratory chain	copper ion binding, cytochrome-c oxidase activity, electron carrier activity, heme binding, metal ion binding, oxidoreductase activity		
Q0255	Q0255	Maturase-like protein [Source:SGD;Acc:S000007282]	biological_process, intron homing	mitochondrion	DNA binding, endonuclease activity, molecular_function		
Q0275	COX3	Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits [Source:SGD;Acc:S000007283]	aerobic respiration, mitochondrial electron transport, cytochrome c to oxygen, oxidation-reduction process, respiratory electron transport chain	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion	cytochrome-c oxidase activity, oxidoreductase activity		
Q0297	Q0297	Dubious open reading frame of the mitochondrial genome; unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RPM1 [Source:SGD;Acc:S000007284]					
R0010W	FLP1	Site-specific recombinase encoded on the 2-micron plasmid, required for 2-micron plasmid propagation as part of a plasmid amplification system that compensates for any copy number decreases caused by missegregation events [Source:SGD;Acc:S000029654]	plasmid recombination	cellular_component	DNA bending activity, DNA binding, double-stranded DNA binding, single-stranded DNA binding, site-specific recombinase activity		
R0020C	REP1	Master regulator that acts in concert with Rep2p to regulate transcript levels of the FLP1 gene that promotes plasmid copy amplification; autoregulates levels of its own transcript [Source:SGD;Acc:S000029675]	2-micrometer plasmid partitioning	nucleus	molecular_function		
R0030W	RAF1	Anti-repressor that increases 2 micron plasmid copy number by relieving repression of the FLP1 site-specific recombinase caused by the Rep1-Rep2p trascription regulator; also itself repressed by the Rep1p-Rep2p complex [Source:SGD;Acc:S000029674]	plasmid maintenance	nucleus	molecular_function		
R0040C	REP2	Master regulator that acts in concert with Rep1p to regulate transcript levels of the FLP1 gene that promotes plasmid copy amplification; also autoregulates levels of its own transcript [Source:SGD;Acc:S000029676]	2-micrometer plasmid partitioning	nucleus	molecular_function		
YAL001C	TFC3	Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding [Source:SGD;Acc:S000000001]	protein localization to chromatin, transcription initiation from RNA polymerase III promoter	mitochondrion, nuclear condensin complex, nucleus, transcription factor TFIIIC complex	DNA binding		
YAL002W	VPS8	Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif [Source:SGD;Acc:S000000002]	late endosome to vacuole transport, protein transport, transport	CORVET complex, Golgi apparatus, Golgi stack, membrane fraction	metal ion binding, molecular_function, protein binding, zinc ion binding		
YAL003W	EFB1	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site [Source:SGD;Acc:S000000003]	translation, translational elongation	eukaryotic translation elongation factor 1 complex, ribosome	guanyl-nucleotide exchange factor activity, translation elongation factor activity		
YAL004W	YAL004W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C [Source:SGD;Acc:S000002136]					
YAL005C	SSA1	ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall [Source:SGD;Acc:S000000004]	SRP-dependent cotranslational protein targeting to membrane, translocation, protein folding, protein import into nucleus, translocation, protein refolding, protein targeting to mitochondrion, response to stress, translation	cell wall, chaperonin-containing T-complex, cytoplasm, extracellular region, fungal-type cell wall, fungal-type vacuole membrane, nucleus, plasma membrane enriched fraction	ATP binding, ATPase activity, nucleotide binding, unfolded protein binding		
YAL007C	ERP2	Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles [Source:SGD;Acc:S000000005]	ER to Golgi vesicle-mediated transport, protein transport, transport, vesicle-mediated transport	ER to Golgi transport vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YAL008W	FUN14	Mitochondrial protein of unknown function [Source:SGD;Acc:S000000006]	biological_process	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YAL009W	SPO7	Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation [Source:SGD;Acc:S000000007]	ascospore formation, meiosis, nuclear envelope organization, regulation of phospholipid biosynthetic process, sporulation resulting in formation of a cellular spore	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear membrane, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus	phosphoprotein phosphatase activity		
YAL010C	MDM10	Subunit of both the ERMES complex that links the ER to mitochondria, and of the mitochondrial sorting and assembly machinery (SAM complex) that functions in import and assembly of outer membrane beta-barrel proteins [Source:SGD;Acc:S000000008]	mitochondrial genome maintenance, mitochondrial outer membrane translocase complex assembly, mitochondrion inheritance, mitochondrion organization, phospholipid transport, protein import into mitochondrial outer membrane	ERMES complex, integral to membrane, membrane, mitochondrial outer membrane, mitochondrial sorting and assembly machinery complex, mitochondrion	molecular_function		
YAL011W	SWC3	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae [Source:SGD;Acc:S000000009]	chromatin modification, chromatin remodeling, endoplasmic reticulum organization, histone exchange	Swr1 complex, mitochondrion, nucleus	molecular_function		
YAL012W	CYS3	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine [Source:SGD;Acc:S000000010]	cellular amino acid biosynthetic process, cellular amino acid metabolic process, cysteine biosynthetic process, cysteine biosynthetic process via cystathionine, cysteine metabolic process, sulfur amino acid metabolic process, transsulfuration	cytoplasm	catalytic activity, cystathionine gamma-lyase activity, lyase activity, pyridoxal phosphate binding		
YAL013W	DEP1	Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation [Source:SGD;Acc:S000000011]	chromatin modification, histone deacetylation, negative regulation of chromatin silencing at telomere, phospholipid metabolic process, regulation of DNA-dependent DNA replication initiation, regulation of transcription from RNA polymerase II promoter	Rpd3L complex, Rpd3L-Expanded complex, cytoplasm, nucleus	histone deacetylase activity		
YAL014C	SYN8	Endosomal SNARE related to mammalian syntaxin 8 [Source:SGD;Acc:S000000012]	protein transport, transport	endosome, endosome membrane, integral to membrane, membrane	SNAP receptor activity, protein binding		
YAL015C	NTG1	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress [Source:SGD;Acc:S000000013]	DNA repair, base-excision repair, base-excision repair, AP site formation, cellular response to oxidative stress, metabolic process, positive regulation of mitochondrial DNA replication, response to DNA damage stimulus	mitochondrion, nucleus	DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity, catalytic activity, endonuclease activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, oxidized purine base lesion DNA N-glycosylase activity, oxidized pyrimidine base lesion DNA N-glycosylase activity		
YAL016C-A	YAL016C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028728]					
YAL016C-B	YAL016C-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028528]					
YAL016W	TPD3	Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A), which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III [Source:SGD;Acc:S000000014]	actin filament organization, budding cell bud growth, mitotic cell cycle spindle assembly checkpoint, protein dephosphorylation, regulation of translation	cellular bud neck, cellular bud tip, cytoplasm, mating projection tip, nucleus, protein phosphatase type 2A complex, spindle pole body	binding, protein serine/threonine phosphatase activity		
YAL017W	PSK1	One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status [Source:SGD;Acc:S000000015]	negative regulation of glycogen biosynthetic process, protein phosphorylation, regulation of 1,6-beta-glucan biosynthetic process, signal transduction	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, signal transducer activity, transferase activity		
YAL018C	YAL018C	Putative protein of unknown function [Source:SGD;Acc:S000000016]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YAL019W	FUN30	Conserved member of the Snf2p family with ATP-dependent chromatin remodeling activity; has a role in silencing; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000017]	chromatin silencing at rDNA, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, chromosome organization	mating-type region heterochromatin, mitochondrion, nucleus	ATP binding, DNA binding, DNA-dependent ATPase activity, chromatin binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein homodimerization activity		
YAL019W-A	YAL019W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028729]					
YAL020C	ATS1	Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle [Source:SGD;Acc:S000000018]	budding cell bud growth, microtubule cytoskeleton organization, microtubule-based process, tRNA wobble uridine modification	cytoplasm	molecular_function		
YAL021C	CCR4	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening [Source:SGD;Acc:S000000019]	DNA replication, DNA replication checkpoint, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, nuclear-transcribed mRNA poly(A) tail shortening, regulation of transcription from RNA polymerase II promoter, replication fork protection, transcription elongation from RNA polymerase II promoter, traversing start control point of mitotic cell cycle	CCR4-NOT core complex, Cdc73/Paf1 complex, cytoplasm, cytoplasmic mRNA processing body, nucleus	3'-5'-exoribonuclease activity, RNA binding, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, poly(A)-specific ribonuclease activity, protein binding		
YAL022C	FUN26	Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes [Source:SGD;Acc:S000000020]	nucleoside transport, transmembrane transport, transport	integral to membrane, intracellular, membrane	nucleoside transmembrane transporter activity		
YAL023C	PMT2	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein Ser/Thr residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5; target for new antifungal [Source:SGD;Acc:S000000021]	ER-associated misfolded protein catabolic process, protein O-linked glycosylation, protein exit from endoplasmic reticulum	dolichyl-phosphate-mannose-protein mannosyltransferase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YAL024C	LTE1	Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures [Source:SGD;Acc:S000000022]	cell cycle, cell division, mitosis, mitotic cell cycle spindle orientation checkpoint, regulation of exit from mitosis, regulation of small GTPase mediated signal transduction, small GTPase mediated signal transduction, vesicle-mediated transport	cellular bud, cytoplasm, intracellular	guanyl-nucleotide exchange factor activity		
YAL025C	MAK16	Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus [Source:SGD;Acc:S000000023]	cell cycle, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal large subunit biogenesis, translation	intracellular, nucleolus, nucleus, preribosome, large subunit precursor, ribosome	molecular_function, structural constituent of ribosome		
YAL026C	DRS2	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease [Source:SGD;Acc:S000000024]	ATP biosynthetic process, endocytosis, intracellular protein transport, metabolic process, phospholipid translocation, phospholipid transport, post-Golgi vesicle-mediated transport, ribosomal small subunit assembly	Golgi apparatus, integral to membrane, membrane, trans-Golgi network	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, magnesium ion binding, nucleotide binding, phospholipid-translocating ATPase activity		
YAL026C-A	YAL026C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAL027W and the verified gene DRS2 [Source:SGD;Acc:S000028730]					
YAL027W	SAW1	Protein involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus [Source:SGD;Acc:S000000025]	DNA repair, double-strand break repair via single-strand annealing, removal of nonhomologous ends, response to DNA damage stimulus	nucleus	molecular_function		
YAL028W	FRT2	Tail-anchored ER membrane protein, interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate [Source:SGD;Acc:S000000026]	response to stress	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YAL029C	MYO4	One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p [Source:SGD;Acc:S000000027]	endoplasmic reticulum inheritance, intracellular mRNA localization, mating type switching	cellular bud, cellular bud tip, filamentous actin, mitochondrion, myosin V complex, myosin complex	ATP binding, actin binding, actin filament binding, calmodulin binding, microfilament motor activity, motor activity, nucleotide binding, protein binding		
YAL030W	SNC1	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins [Source:SGD;Acc:S000000028]	Golgi to plasma membrane transport, endocytosis, vesicle fusion, vesicle-mediated transport	SNARE complex, cellular bud neck, endomembrane system, endosome, integral to membrane, membrane, plasma membrane, trans-Golgi network, transport vesicle	SNAP receptor activity		
YAL031C	GIP4	Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate [Source:SGD;Acc:S000000029]	chromosome segregation, regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase 1 binding, protein phosphatase type 1 regulator activity		
YAL031W-A	YAL031W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028731]					
YAL032C	PRP45	Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene [Source:SGD;Acc:S000000030]	RNA splicing, generation of catalytic spliceosome for second transesterification step, mRNA processing, nuclear mRNA splicing, via spliceosome	U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, nucleus, post-mRNA release spliceosomal complex, spliceosomal complex	first spliceosomal transesterification activity, second spliceosomal transesterification activity		
YAL033W	POP5	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends [Source:SGD;Acc:S000000031]	intronic box C/D snoRNA processing, mRNA cleavage, rRNA processing, tRNA processing	cytoplasm, nucleolar ribonuclease P complex, nucleus, ribonuclease MRP complex	hydrolase activity, ribonuclease MRP activity, ribonuclease P activity, ribonuclease activity		
YAL034C	FUN19	Non-essential protein of unknown function; expression induced in response to heat stress [Source:SGD;Acc:S000002134]	biological_process	cellular_component	molecular_function, protein binding		
YAL034C-B	YAL034C-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002137]					
YAL034W-A	MTW1	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly [Source:SGD;Acc:S000000032]	cell cycle, cell division, chromosome segregation, mitosis, protein localization to kinetochore	chromosome, centromeric region, condensed chromosome kinetochore, kinetochore, nuclear MIS12/MIND type complex, nucleus, spindle pole	molecular_function		
YAL035W	FUN12	GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2 [Source:SGD;Acc:S000000033]	translation, translational initiation	cytosolic small ribosomal subunit, mitochondrion	GTP binding, GTPase activity, nucleotide binding, translation initiation factor activity		
YAL036C	RBG1	Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid [Source:SGD;Acc:S000000034]	translation	cytoplasm, intracellular, polysomal ribosome, polysome	GTP binding, nucleotide binding		
YAL037C-A	YAL037C-A	Putative protein of unknown function [Source:SGD;Acc:S000028732]	biological_process	cellular_component	molecular_function		
YAL037C-B	YAL037C-B	Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028592]					
YAL037W	YAL037W	Putative protein of unknown function [Source:SGD;Acc:S000000035]	biological_process	cellular_component	molecular_function		
YAL038W	CDC19	Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration [Source:SGD;Acc:S000000036]	glycolysis, pyruvate metabolic process	cytosol, plasma membrane enriched fraction	ATP binding, catalytic activity, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, potassium ion binding, pyruvate kinase activity, transferase activity		
YAL039C	CYC3	Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS) [Source:SGD;Acc:S000000037]	cytochrome c-heme linkage	membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion	holocytochrome-c synthase activity, lyase activity, metal ion binding		
YAL040C	CLN3	G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis [Source:SGD;Acc:S000000038]	G1/S transition of mitotic cell cycle, cell cycle, cell division, regulation of cell size, regulation of cyclin-dependent protein kinase activity, regulation of transcription involved in G1/S phase of mitotic cell cycle, vacuole fusion, non-autophagic, vacuole organization	nucleus	cyclin-dependent protein kinase regulator activity		
YAL041W	CDC24	Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing [Source:SGD;Acc:S000000039]	budding cell apical bud growth, budding cell isotropic bud growth, cell morphogenesis involved in conjugation with cellular fusion, chitin localization, establishment of cell polarity, intracellular signal transduction, invasive growth in response to glucose limitation, pheromone-dependent signal transduction involved in conjugation with cellular fusion, pseudohyphal growth, regulation of Rho protein signal transduction, regulation of exit from mitosis, small GTPase mediated signal transduction	cellular bud neck, cellular bud tip, cytoplasm, incipient cellular bud site, intracellular, mating projection tip, nucleus	Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity, protein binding		
YAL042C-A	YAL042C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene [Source:SGD;Acc:S000002138]					
YAL042W	ERV46	Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport [Source:SGD;Acc:S000000040]	ER to Golgi vesicle-mediated transport, protein transport, transport, vesicle-mediated transport	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to Golgi membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YAL043C	PTA1	Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII [Source:SGD;Acc:S000000041]	mRNA cleavage, mRNA polyadenylation, mRNA processing, tRNA processing, termination of RNA polymerase II transcription, exosome-dependent, termination of RNA polymerase II transcription, poly(A)-coupled	mRNA cleavage and polyadenylation specificity factor complex, mRNA cleavage factor complex, nucleus	RNA binding		
YAL044C	GCV3	H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF [Source:SGD;Acc:S000000042]	glycine catabolic process, glycine decarboxylation via glycine cleavage system, one-carbon metabolic process, protein lipoylation	glycine cleavage complex, mitochondrion	glycine dehydrogenase (decarboxylating) activity		
YAL044W-A	YAL044W-A	Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein [Source:SGD;Acc:S000007586]	biological_process	cellular_component	molecular_function		
YAL045C	YAL045C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A [Source:SGD;Acc:S000000043]					
YAL046C	AIM1	Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000000044]	biological_process	cellular_component	molecular_function		
YAL047C	SPC72	Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization [Source:SGD;Acc:S000000045]	cell cycle, cell division, karyogamy, microtubule nucleation, mitotic cell cycle spindle orientation checkpoint, mitotic sister chromatid segregation, mitotic spindle elongation, nuclear migration along microtubule	cytoplasm, cytoskeleton, nucleus, outer plaque of spindle pole body, spindle pole body	structural constituent of cytoskeleton		
YAL047W-A	YAL047W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028733]					
YAL048C	GEM1	Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death [Source:SGD;Acc:S000000046]	mitochondrion inheritance, mitochondrion transport along microtubule, small GTPase mediated signal transduction, vesicle-mediated transport	integral to membrane, intracellular, membrane, mitochondrial outer membrane, mitochondrion	GTP binding, GTPase activity, calcium ion binding, hydrolase activity, nucleotide binding		
YAL049C	AIM2	Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor [Source:SGD;Acc:S000000047]	biological_process	cytoplasm	hydrolase activity, molecular_function		
YAL051W	OAF1	Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis [Source:SGD;Acc:S000000048]	fatty acid metabolic process, peroxisome organization, regulation of transcription, DNA-dependent, sporulation resulting in formation of a cellular spore	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YAL053W	FLC2	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance [Source:SGD;Acc:S000000049]	FAD transport, fungal-type cell wall biogenesis, protein folding, transmembrane transport, transport	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	FAD transmembrane transporter activity		
YAL054C	ACS1	Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions [Source:SGD;Acc:S000000050]	acetate fermentation, acetyl-CoA biosynthetic process, histone acetylation, metabolic process	cytoplasm, cytosol, endoplasmic reticulum, microsome, mitochondrion, nucleus	AMP binding, ATP binding, acetate-CoA ligase activity, catalytic activity, ligase activity, nucleotide binding		
YAL055W	PEX22	Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation [Source:SGD;Acc:S000000051]	peroxisome organization, protein import into peroxisome matrix, receptor recycling, protein targeting to peroxisome	integral to membrane, integral to peroxisomal membrane, membrane, peroxisomal membrane, peroxisome	protein anchor		
YAL056C-A	YAL056C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002139]					
YAL056W	GPB2	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p [Source:SGD;Acc:S000000052]	ascospore formation, glucose mediated signaling pathway, invasive growth in response to glucose limitation, negative regulation of Ras protein signal transduction, positive regulation of transcription from RNA polymerase II promoter, pseudohyphal growth, signal transduction	cytoplasm, mitochondrion, plasma membrane	GTPase activating protein binding, cAMP-dependent protein kinase inhibitor activity, signal transducer activity		
YAL058W	CNE1	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast [Source:SGD;Acc:S000000054]	ER-associated protein catabolic process, protein folding	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	calcium ion binding, sugar binding, unfolded protein binding		
YAL059C-A	YAL059C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene ECM1/YAL059W [Source:SGD;Acc:S000028734]					
YAL059W	ECM1	Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm [Source:SGD;Acc:S000000055]	fungal-type cell wall organization, ribosomal large subunit export from nucleus	nucleolus, nucleus, preribosome, large subunit precursor	molecular_function		
YAL060W	BDH1	NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source [Source:SGD;Acc:S000000056]	alcohol metabolic process, butanediol biosynthetic process, metabolic process, oxidation-reduction process	cytoplasm	(R,R)-butanediol dehydrogenase activity, binding, catalytic activity, metal ion binding, oxidoreductase activity, zinc ion binding		
YAL061W	BDH2	Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3 [Source:SGD;Acc:S000000057]	biological_process, metabolic process, oxidation-reduction process	cytoplasm, nucleus	(R,R)-butanediol dehydrogenase activity, binding, catalytic activity, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, zinc ion binding		
YAL062W	GDH3	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources [Source:SGD;Acc:S000000058]	ammonia assimilation cycle, cellular amino acid metabolic process, glutamate biosynthetic process, metabolic process, oxidation-reduction process	mitochondrion, nucleus, soluble fraction	binding, catalytic activity, glutamate dehydrogenase (NADP+) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor		
YAL063C	FLO9	Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation [Source:SGD;Acc:S000000059]	flocculation, flocculation via cell wall protein-carbohydrate interaction	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	mannose binding		
YAL063C-A	YAL063C-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028813]	biological_process	cellular_component	molecular_function		
YAL064C-A	YAL064C-A	Putative protein of unknown function; YAL064C-A is not an essential gene [Source:SGD;Acc:S000002140]	biological_process	cellular_component	molecular_function		
YAL064W	YAL064W	Protein of unknown function; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000000060]	biological_process	cellular_component	molecular_function		
YAL064W-B	YAL064W-B	Fungal-specific protein of unknown function [Source:SGD;Acc:S000002141]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YAL065C	YAL065C	Putative protein of unknown function; has homology to FLO1; possible pseudogene [Source:SGD;Acc:S000001817]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YAL066W	YAL066W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000061]					
YAL067C	SEO1	Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide [Source:SGD;Acc:S000000062]	transmembrane transport, transport	integral to membrane, membrane	transporter activity		
YAL067W-A	YAL067W-A	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028593]	biological_process	cellular_component	molecular_function		
YAL068C	PAU8	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000002142]	ascospore formation, positive regulation of transcription from RNA polymerase II promoter, response to stress	cellular_component	molecular_function		
YAL068W-A	YAL068W-A	Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028594]					
YAL069W	YAL069W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002143]					
YAR002C-A	ERP1	Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles [Source:SGD;Acc:S000002129]	ER to Golgi vesicle-mediated transport, protein transport, transport, vesicle-mediated transport	ER to Golgi transport vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion	molecular_function		
YAR002W	NUP60	Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; involved in nuclear export and cytoplasmic localization of specific mRNAs such as ASH1 [Source:SGD;Acc:S000000063]	intracellular mRNA localization, mRNA transport, nucleocytoplasmic transport, poly(A)+ mRNA export from nucleus, protein import into nucleus, docking, protein transport, transmembrane transport, transport	membrane, nuclear membrane, nuclear pore, nucleus	structural constituent of nuclear pore		
YAR003W	SWD1	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 [Source:SGD;Acc:S000000064]	chromatin silencing at telomere, histone H3-K4 methylation, regulation of transcription, DNA-dependent, telomere maintenance	Set1C/COMPASS complex, chromosome, telomeric region, nucleus	histone methyltransferase activity (H3-K4 specific), protein binding		
YAR007C	RFA1	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination [Source:SGD;Acc:S000000065]	DNA repair, DNA replication, DNA unwinding involved in replication, double-strand break repair via homologous recombination, establishment of protein localization, heteroduplex formation, mitotic recombination, nucleotide-excision repair, protein ubiquitination, reciprocal meiotic recombination, telomere maintenance via recombination, telomere maintenance via telomerase	DNA replication factor A complex, chromosome, telomeric region, condensed nuclear chromosome, cytoplasm, nucleus	DNA binding, double-stranded DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, single-stranded DNA binding		
YAR008W	SEN34	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease [Source:SGD;Acc:S000000066]	tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation, tRNA-type intron splice site recognition and cleavage	endomembrane system, membrane, mitochondrial outer membrane, mitochondrion, nucleus, tRNA-intron endonuclease complex	endonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, tRNA-intron endonuclease activity		
YAR009C	YAR009C	Retrotransposon TYA Gag and TYB Pol genes; in YARCTY1-1 TYB is mutant and probably non-functional [Source:SGD;Acc:S000000067]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated	cytoplasm, nucleus, retrotransposon nucleocapsid	DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YAR010C	YAR010C	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; in YARCTY1-1 TYB is mutant and probably non-functional [Source:SGD;Acc:S000000068]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YAR014C	BUD14	Protein involved in bud-site selection, Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern [Source:SGD;Acc:S000000069]	cell cycle, cell division, cytoskeleton organization, negative regulation of actin filament polymerization, regulation of cell shape during vegetative growth phase, regulation of protein localization, regulation of transcription, DNA-dependent	cellular bud neck, cellular bud tip, incipient cellular bud site	protein phosphatase type 1 regulator activity		
YAR015W	ADE1	N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine [Source:SGD;Acc:S000000070]	'de novo' IMP biosynthetic process, purine nucleotide biosynthetic process	cytoplasm, nucleus	ATP binding, catalytic activity, ligase activity, nucleotide binding, phosphoribosylaminoimidazolesuccinocarboxamide synthase activity		
YAR018C	KIN3	Nonessential protein kinase with unknown cellular role [Source:SGD;Acc:S000000071]	chromosome segregation, protein phosphorylation	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YAR019C	CDC15	Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II [Source:SGD;Acc:S000000072]	cell cycle, cell division, cytokinesis, meiotic anaphase II, mitosis, protein phosphorylation, regulation of exit from mitosis	cellular bud neck, spindle pole body	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YAR019W-A	YAR019W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028735]					
YAR020C	PAU7	Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme [Source:SGD;Acc:S000000073]	biological_process, response to stress	cellular_component	molecular_function		
YAR023C	YAR023C	Putative integral membrane protein, member of DUP240 gene family [Source:SGD;Acc:S000000074]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YAR027W	UIP3	Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family [Source:SGD;Acc:S000000075]	biological_process	integral to membrane, membrane, nuclear envelope, nuclear membrane, nucleus, plasma membrane	molecular_function		
YAR028W	YAR028W	Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000000076]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YAR029W	YAR029W	Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000000077]	biological_process	cytoplasm, membrane	molecular_function		
YAR030C	YAR030C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 [Source:SGD;Acc:S000001821]					
YAR031W	PRM9	Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family [Source:SGD;Acc:S000000078]	transport, vesicle organization, vesicle-mediated transport	endoplasmic reticulum, integral to membrane, membrane, plasma membrane	molecular_function		
YAR033W	MST28	Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles [Source:SGD;Acc:S000000079]	protein transport, transport, vesicle organization, vesicle-mediated transport	COPI coated vesicle membrane, ER to Golgi transport vesicle membrane, Golgi apparatus, cytoplasmic vesicle, endoplasmic reticulum, integral to membrane, membrane, plasma membrane	molecular_function		
YAR035C-A	YAR035C-A	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational "guilt by association" analysis [Source:SGD;Acc:S000028595]	biological_process	cellular_component	molecular_function		
YAR035W	YAT1	Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated [Source:SGD;Acc:S000000080]	alcohol metabolic process, carnitine metabolic process, fatty acid metabolic process, lipid metabolic process, transport	membrane, mitochondrial inner membrane, mitochondrion	acyltransferase activity, carnitine O-acetyltransferase activity, transferase activity		
YAR042W	SWH1	Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction [Source:SGD;Acc:S000000081]	endocytosis, exocytosis, lipid transport, maintenance of cell polarity, steroid metabolic process, sterol transport, transport	Golgi apparatus, Golgi membrane, Golgi trans cisterna, cytoplasm, early endosome, endoplasmic reticulum, membrane, nuclear envelope, nuclear outer membrane, nucleus	1-phosphatidylinositol binding, lipid binding, oxysterol binding, protein binding, sterol transporter activity		
YAR047C	YAR047C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000083]					
YAR050W	FLO1	Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p [Source:SGD;Acc:S000000084]	cellular response to stress, flocculation, flocculation via cell wall protein-carbohydrate interaction	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane, plasma membrane	mannose binding		
YAR053W	YAR053W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000085]					
YAR060C	YAR060C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000086]					
YAR064W	YAR064W	Putative protein of unknown function [Source:SGD;Acc:S000000089]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YAR066W	YAR066W	Putative GPI protein [Source:SGD;Acc:S000002144]	biological_process	cellular_component, extracellular region	molecular_function		
YAR068W	YAR068W	Fungal-specific protein of unknown function; induced in respiratory-deficient cells [Source:SGD;Acc:S000000091]	biological_process	cellular_component	molecular_function		
YAR069C	YAR069C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000092]					
YAR070C	YAR070C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000093]					
YAR071W	PHO11	One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 [Source:SGD;Acc:S000000094]	phosphate metabolic process	extracellular region	acid phosphatase activity, hydrolase activity, phosphatase activity		
YAR073W	IMD1	Nonfunctional protein with homology to IMP dehydrogenase; probable pseudogene, located close to the telomere; is not expressed at detectable levels; YAR073W and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae [Source:SGD;Acc:S000000095]					
YAR075W	YAR075W	Non-functional protein with homology IMP dehydrogenase; YAR073W/IMD1 and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae. [Source:SGD;Acc:S000002145]					
YBL001C	ECM15	Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis [Source:SGD;Acc:S000000097]	fungal-type cell wall organization	cytoplasm, nucleus	molecular_function		
YBL002W	HTB2	Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation [Source:SGD;Acc:S000000098]	chromatin assembly or disassembly, nucleosome assembly	chromosome, nuclear nucleosome, nucleosome, nucleus, replication fork protection complex	DNA binding		
YBL003C	HTA2	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p [Source:SGD;Acc:S000000099]	DNA repair, chromatin assembly or disassembly, nucleosome assembly, response to DNA damage stimulus	chromosome, nuclear nucleosome, nucleosome, nucleus, replication fork protection complex	DNA binding		
YBL004W	UTP20	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA [Source:SGD;Acc:S000000100]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, cytoplasm, nucleolus, nucleoplasm, nucleus, preribosome, small subunit precursor, ribonucleoprotein complex, small-subunit processome	binding, molecular_function		
YBL005W	PDR3	Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements) [Source:SGD;Acc:S000000101]	negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to drug	cytoplasm, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YBL005W-A	YBL005W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000002146]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YBL005W-B	YBL005W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000002147]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YBL006C	LDB7	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions [Source:SGD;Acc:S000000102]	ATP-dependent chromatin remodeling, cell wall mannoprotein biosynthetic process, chromatin modification, nucleosome disassembly, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	DNA-dependent ATPase activity		
YBL006W-A	YBL006W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene LDB7/YBL006C [Source:SGD;Acc:S000028596]					
YBL007C	SLA1	Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains [Source:SGD;Acc:S000000103]	actin cortical patch assembly, actin filament organization, bipolar cellular bud site selection, endocytosis, fungal-type cell wall organization	actin cortical patch, cell cortex, cytoplasm, cytoskeleton, endosome, endosome membrane, mating projection tip, membrane, nucleus, plasma membrane	actin binding, cytoskeletal protein binding, protein binding, protein binding, bridging, ubiquitin binding		
YBL008W	HIR1	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores [Source:SGD;Acc:S000000104]	DNA replication-independent nucleosome assembly, chromatin modification, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, transcription elongation from RNA polymerase II promoter	HIR complex, chromosome, centromeric region, nucleus	DNA binding, chromatin binding, nucleosome binding, transcription corepressor activity		
YBL008W-A	YBL008W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028529]	biological_process	cellular_component, extracellular region	molecular_function		
YBL009W	ALK2	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins [Source:SGD;Acc:S000000105]	cell cycle, meiosis, mitosis, protein phosphorylation, response to DNA damage stimulus	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YBL010C	YBL010C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles [Source:SGD;Acc:S000000106]	biological_process	clathrin-coated vesicle, nucleus	DNA binding, molecular_function		
YBL011W	SCT1	Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed [Source:SGD;Acc:S000000107]	metabolic process, phospholipid biosynthetic process	endoplasmic reticulum, integral to membrane, membrane, microsome	acyltransferase activity, glycerol-3-phosphate O-acyltransferase activity, glycerone-phosphate O-acyltransferase activity, transferase activity		
YBL012C	YBL012C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000108]					
YBL013W	FMT1	Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate [Source:SGD;Acc:S000000109]	biosynthetic process, methionyl-tRNA aminoacylation, translation, translational initiation	mitochondrion	hydroxymethyl-, formyl- and related transferase activity, methionyl-tRNA formyltransferase activity, methyltransferase activity, transferase activity		
YBL014C	RRN6	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p [Source:SGD;Acc:S000000110]	transcription from RNA polymerase I promoter, transcription initiation from RNA polymerase I promoter, transcription of nuclear rRNA large RNA polymerase I transcript	RNA polymerase I core factor complex, cytoplasm, nucleolus, nucleus			
YBL015W	ACH1	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth [Source:SGD;Acc:S000000111]	acetate metabolic process, acetyl-CoA metabolic process	cytoplasm, cytosol, mitochondrion	acetate CoA-transferase activity, acetyl-CoA hydrolase activity, catalytic activity, hydrolase activity		
YBL016W	FUS3	Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation [Source:SGD;Acc:S000000112]	cell cycle, cell cycle arrest, cell division, conjugation, invasive growth in response to glucose limitation, mitosis, negative regulation of MAPKKK cascade, negative regulation of transposition, RNA-mediated, pheromone-dependent signal transduction involved in conjugation with cellular fusion, protein phosphorylation	cytoplasm, mating projection tip, mitochondrion, nucleus, periplasmic space	ATP binding, MAP kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YBL017C	PEP1	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments [Source:SGD;Acc:S000000113]	ER-associated protein catabolic process, protein targeting to vacuole, vacuolar transport	Golgi apparatus, integral to membrane, membrane	nucleotide binding, receptor activity, signal sequence binding		
YBL018C	POP8	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends [Source:SGD;Acc:S000000114]	intronic box C/D snoRNA processing, mRNA cleavage, rRNA processing, tRNA processing	nucleolar ribonuclease P complex, nucleus, ribonuclease MRP complex	hydrolase activity, ribonuclease MRP activity, ribonuclease P activity		
YBL019W	APN2	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII [Source:SGD;Acc:S000000115]	DNA repair, base-excision repair, response to DNA damage stimulus	intracellular, nucleus	DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity, double-stranded DNA specific 3'-5' exodeoxyribonuclease activity, endonuclease activity, lyase activity, nuclease activity, phosphoric diester hydrolase activity, zinc ion binding		
YBL020W	RFT1	Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein [Source:SGD;Acc:S000000116]	carbohydrate transport, glycolipid translocation, lipid transport, protein N-linked glycosylation, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	lipid transporter activity, molecular_function		
YBL021C	HAP3	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding [Source:SGD;Acc:S000000117]	regulation of carbohydrate metabolic process, regulation of transcription, DNA-dependent	CCAAT-binding factor complex, intracellular, nucleus	DNA binding, sequence-specific DNA binding		
YBL022C	PIM1	ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria [Source:SGD;Acc:S000000118]	cellular chaperone-mediated protein complex assembly, misfolded or incompletely synthesized protein catabolic process, proteolysis	mitochondrial matrix, mitochondrion	ATP binding, ATP-dependent peptidase activity, DNA binding, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity		
YBL023C	MCM2	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex [Source:SGD;Acc:S000000119]	DNA replication, DNA strand elongation involved in DNA replication, DNA-dependent DNA replication initiation, S phase of mitotic cell cycle, cell cycle, double-strand break repair via break-induced replication, pre-replicative complex assembly	DNA replication preinitiation complex, MCM complex, cytoplasm, nucleus, pre-replicative complex, replication fork protection complex	ATP binding, DNA binding, DNA replication origin binding, chromatin binding, metal ion binding, nucleotide binding, single-stranded DNA binding		
YBL024W	NCL1	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120 [Source:SGD;Acc:S000000120]	tRNA methylation, tRNA processing	nucleolus, nucleus	RNA binding, methyltransferase activity, tRNA (cytosine-5-)-methyltransferase activity, tRNA binding, transferase activity		
YBL025W	RRN10	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I [Source:SGD;Acc:S000000121]	transcription from RNA polymerase I promoter	RNA polymerase I upstream activating factor complex, nucleolus, nucleus	rDNA binding		
YBL026W	LSM2	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000000122]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, rRNA processing, tRNA processing	U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, cytoplasmic mRNA processing body, nucleolus, nucleus, ribonucleoprotein complex, small nucleolar ribonucleoprotein complex	RNA binding		
YBL027W	RPL19B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal [Source:SGD;Acc:S000000123]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YBL028C	YBL028C	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000000124]	biological_process	nucleolus, nucleus, preribosome, large subunit precursor, ribosome	molecular_function		
YBL029C-A	YBL029C-A	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica [Source:SGD;Acc:S000007591]	biological_process	membrane, plasma membrane, plasma membrane enriched fraction	molecular_function		
YBL029W	YBL029W	Non-essential protein of unknown function [Source:SGD;Acc:S000000125]	biological_process	cytoplasm, nucleus	molecular_function		
YBL030C	PET9	Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation [Source:SGD;Acc:S000000126]	ADP transport, ATP transport, aerobic respiration, anaerobic respiration, apoptosis, heme transport, mitochondrial transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	ATP:ADP antiporter activity, binding, transporter activity		
YBL031W	SHE1	Mitotic spindle protein that interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure [Source:SGD;Acc:S000000127]	cell cycle, cell division, chromosome segregation, mitosis, mitotic spindle elongation	astral microtubule, cellular bud neck, cytoplasm, cytoskeleton, microtubule cytoskeleton, nuclear microtubule, spindle	molecular_function		
YBL032W	HEK2	RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K [Source:SGD;Acc:S000000128]	intracellular mRNA localization, mRNA stabilization, telomere maintenance via telomerase	cytoplasm, cytoplasmic mRNA processing body, nuclear chromosome, telomeric region	RNA binding, mRNA binding		
YBL033C	RIB1	GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway [Source:SGD;Acc:S000000129]	riboflavin biosynthetic process	cytoplasm, nucleus	GTP binding, GTP cyclohydrolase II activity, cyclohydrolase activity, hydrolase activity, metal ion binding, nucleotide binding		
YBL034C	STU1	Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles [Source:SGD;Acc:S000000130]	cell cycle, cell division, microtubule nucleation, mitosis	chromosome, centromeric region, condensed chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle, spindle pole body	binding, structural constituent of cytoskeleton		
YBL035C	POL12	B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation [Source:SGD;Acc:S000000131]	DNA replication, DNA-dependent DNA replication initiation, lagging strand elongation, telomere capping	alpha DNA polymerase:primase complex, nuclear envelope, nucleus	DNA binding, DNA-directed DNA polymerase activity		
YBL036C	YBL036C	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000000132]	biological_process	cellular_component	pyridoxal phosphate binding		
YBL037W	APL3	Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport [Source:SGD;Acc:S000000133]	intracellular protein transport, protein transport, vesicle-mediated transport	AP-2 adaptor complex, clathrin adaptor complex, coated pit, membrane, membrane coat, plasma membrane	binding, molecular_function, protein transporter activity		
YBL038W	MRPL16	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000000134]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	peptidyltransferase activity, rRNA binding, structural constituent of ribosome		
YBL039C	URA7	Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis [Source:SGD;Acc:S000000135]	CTP biosynthetic process, glutamine metabolic process, phospholipid biosynthetic process, pyrimidine base biosynthetic process, pyrimidine nucleotide biosynthetic process	cytosol	ATP binding, CTP synthase activity, catalytic activity, ligase activity, nucleotide binding		
YBL039C-A	YBL039C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF URA7; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028814]					
YBL039W-B	YBL039W-B	Putative protein of unknown function [Source:SGD;Acc:S000028517]	biological_process	cellular_component	molecular_function		
YBL040C	ERD2	HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins [Source:SGD;Acc:S000000136]	ER to Golgi vesicle-mediated transport, protein retention in ER lumen, protein transport, transport, vesicle-mediated transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	ER retention sequence binding, HDEL sequence binding, receptor activity		
YBL041W	PRE7	Beta 6 subunit of the 20S proteasome [Source:SGD;Acc:S000000137]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteolysis involved in cellular protein catabolic process	cytoplasm, endoplasmic reticulum membrane, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, molecular_function, peptidase activity, threonine-type endopeptidase activity		
YBL042C	FUI1	High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport [Source:SGD;Acc:S000000138]	nucleobase, nucleoside, nucleotide and nucleic acid transport, transmembrane transport, transport, uridine transport	integral to membrane, membrane, plasma membrane	nucleobase transmembrane transporter activity, uridine transmembrane transporter activity		
YBL043W	ECM13	Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000000139]	cellular cell wall organization, fungal-type cell wall organization	cellular_component	molecular_function		
YBL044W	YBL044W	Putative protein of unknown function; YBL044W is not an essential protein [Source:SGD;Acc:S000000140]	biological_process	cellular_component	molecular_function		
YBL045C	COR1	Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain [Source:SGD;Acc:S000000141]	aerobic respiration, electron transport chain, proteolysis, transport	membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex III, mitochondrion, respiratory chain	catalytic activity, metal ion binding, metalloendopeptidase activity, ubiquinol-cytochrome-c reductase activity, zinc ion binding		
YBL046W	PSY4	Putative regulatory subunit of an evolutionarily conserved protein phosphatase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 [Source:SGD;Acc:S000000142]	protein dephosphorylation, response to drug	cytoplasm, nucleus	protein phosphatase regulator activity		
YBL047C	EDE1	Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins [Source:SGD;Acc:S000000143]	endocytosis, endoplasmic reticulum unfolded protein response	actin cortical patch, cellular bud neck, cellular bud tip, cytoplasm, mating projection tip	calcium ion binding, protein binding, ubiquitin binding		
YBL048W	RRT1	Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000000144]					
YBL049W	MOH1	Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase [Source:SGD;Acc:S000000145]	biological_process	cellular_component	molecular_function		
YBL050W	SEC17	Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP [Source:SGD;Acc:S000000146]	SNARE complex disassembly, autophagy, intracellular protein transport, protein transport, transport, vacuole fusion, non-autophagic, vesicle fusion with Golgi apparatus, vesicle-mediated transport	Golgi apparatus, SNARE complex, cytosol, endoplasmic reticulum, membrane, peripheral to membrane of membrane fraction	ATPase activator activity, binding, soluble NSF attachment protein activity		
YBL051C	PIN4	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage [Source:SGD;Acc:S000000147]	DNA damage checkpoint, G2/M transition of mitotic cell cycle	cytoplasm	RNA binding, molecular_function, nucleic acid binding, nucleotide binding		
YBL052C	SAS3	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal [Source:SGD;Acc:S000000148]	chromatin modification, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, histone acetylation	NuA3 histone acetyltransferase complex, nucleus	acyltransferase activity, histone acetyltransferase activity, metal ion binding, transferase activity, transferase activity, transferring acyl groups other than amino-acyl groups		
YBL053W	YBL053W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000149]					
YBL054W	TOD6	PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor, similar to Dot6p; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manne [Source:SGD;Acc:S000000150]	regulation of transcription from RNA polymerase II promoter	Rpd3L complex, Rpd3L-Expanded complex, cytoplasm, nucleus	DNA binding, protein binding, sequence-specific DNA binding		
YBL055C	YBL055C	3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases [Source:SGD;Acc:S000000151]	DNA fragmentation involved in apoptotic nuclear change, cellular response to oxidative stress	cytoplasm	3'-5'-exodeoxyribonuclease activity, endodeoxyribonuclease activity, producing 5'-phosphomonoesters, endonuclease activity, hydrolase activity, nuclease activity		
YBL056W	PTC3	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation [Source:SGD;Acc:S000000152]	inactivation of MAPK activity involved in osmosensory signaling pathway, protein dephosphorylation, regulation of cyclin-dependent protein kinase activity	cytoplasm, nucleus, protein serine/threonine phosphatase complex	catalytic activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YBL057C	PTH2	One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth [Source:SGD;Acc:S000000153]	negative regulation of proteasomal ubiquitin-dependent protein catabolic process, translation	cytoplasm, mitochondrial outer membrane, mitochondrion	aminoacyl-tRNA hydrolase activity, hydrolase activity		
YBL058W	SHP1	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate [Source:SGD;Acc:S000000154]	ascospore formation, autophagic vacuole assembly, glycogen metabolic process, piecemeal microautophagy of nucleus, proteasomal ubiquitin-dependent protein catabolic process, sister chromatid biorientation	cytoplasm, nucleus	protein binding, protein phosphatase type 1 regulator activity		
YBL059C-A	CMC2	Protein of the mitochondrial intermembrane space with a role in respiratory chain complex assembly or maintenance; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold [Source:SGD;Acc:S000007488]	mitochondrial respiratory chain complex assembly	cytoplasm, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, nucleus	metal ion binding, molecular_function		
YBL059W	YBL059W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000155]	biological_process	integral to membrane, membrane, mitochondrion	molecular_function		
YBL060W	YEL1	Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip [Source:SGD;Acc:S000000156]	actin cortical patch localization, positive regulation of phosphatidylinositol biosynthetic process, protein localization, regulation of ARF protein signal transduction	cellular bud neck, cellular bud tip, cytoplasm, intracellular	ARF guanyl-nucleotide exchange factor activity, protein binding		
YBL061C	SKT5	Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation [Source:SGD;Acc:S000000157]	cytokinesis, fungal-type cell wall chitin biosynthetic process, response to osmotic stress	cellular bud neck, cellular bud neck septin ring, incipient cellular bud site, membrane, plasma membrane	binding, enzyme activator activity		
YBL062W	YBL062W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000158]					
YBL063W	KIP1	Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions [Source:SGD;Acc:S000000159]	cell cycle, cell division, microtubule depolymerization, microtubule-based movement, mitosis, mitotic anaphase B, mitotic sister chromatid segregation, plasmid partitioning, spindle pole body separation	cytoplasm, cytoskeleton, kinesin complex, microtubule, spindle, spindle microtubule, spindle pole body	ATP binding, microtubule motor activity, motor activity, nucleotide binding, structural constituent of cytoskeleton		
YBL064C	PRX1	Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated [Source:SGD;Acc:S000000160]	cell redox homeostasis, cellular response to oxidative stress, oxidation-reduction process, response to cadmium ion	mitochondrion	antioxidant activity, oxidoreductase activity, peroxidase activity, peroxiredoxin activity, thioredoxin peroxidase activity		
YBL065W	YBL065W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene [Source:SGD;Acc:S000000161]					
YBL066C	SEF1	Putative transcription factor, has homolog in Kluyveromyces lactis [Source:SGD;Acc:S000000162]	biological_process, regulation of transcription, DNA-dependent, sporulation resulting in formation of a cellular spore	cellular_component, nucleus	DNA binding, metal ion binding, molecular_function, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YBL067C	UBP13	Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions [Source:SGD;Acc:S000000163]	biological_process, ubiquitin-dependent protein catabolic process	cellular_component	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YBL068W	PRS4	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [Source:SGD;Acc:S000000164]	5-phosphoribose 1-diphosphate biosynthetic process, cellular biosynthetic process, fungal-type cell wall organization, nucleoside metabolic process, nucleotide biosynthetic process, ribonucleoside monophosphate biosynthetic process	cytoplasm	ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, ribose phosphate diphosphokinase activity, transferase activity		
YBL068W-A	YBL068W-A	Dubious open reading frame unlikely to encode a protein; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028530]					
YBL069W	AST1	Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts [Source:SGD;Acc:S000000165]	metabolic process, oxidation-reduction process, protein targeting to membrane	extrinsic to membrane, membrane	binding, catalytic activity, molecular_function, oxidoreductase activity, zinc ion binding		
YBL070C	YBL070C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000166]					
YBL071C	YBL071C	Dubious open reading frame, predicted protein contains a peroxisomal targeting signal [Source:SGD;Acc:S000000167]					
YBL071C-B	YBL071C-B	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028597]	biological_process	cellular_component	molecular_function		
YBL071W-A	KTI11	Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs [Source:SGD;Acc:S000007587]	peptidyl-diphthamide biosynthetic process from peptidyl-histidine, tRNA wobble uridine modification	cytoplasm, nucleus	electron carrier activity, iron ion binding, metal ion binding, zinc ion binding		
YBL072C	RPS8A	Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein [Source:SGD;Acc:S000000168]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YBL073W	YBL073W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C [Source:SGD;Acc:S000000169]					
YBL074C	AAR2	Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron [Source:SGD;Acc:S000000170]	RNA splicing, assembly of spliceosomal tri-snRNP, mRNA processing	U5 snRNP, cytoplasm, nucleus	molecular_function		
YBL075C	SSA3	ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm [Source:SGD;Acc:S000000171]	SRP-dependent cotranslational protein targeting to membrane, translocation, protein folding, response to stress	cytoplasm, cytosol	ATP binding, ATPase activity, nucleotide binding, unfolded protein binding		
YBL076C	ILS1	Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A [Source:SGD;Acc:S000000172]	isoleucyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, cytosol	ATP binding, aminoacyl-tRNA ligase activity, isoleucine-tRNA ligase activity, ligase activity, nucleotide binding, zinc ion binding		
YBL077W	YBL077W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C [Source:SGD;Acc:S000000173]					
YBL078C	ATG8	Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation [Source:SGD;Acc:S000000174]	CVT pathway, ER to Golgi vesicle-mediated transport, autophagic vacuole assembly, autophagy, cellular membrane fusion, mitochondrion degradation, piecemeal microautophagy of nucleus, protein transport, transport	CVT vesicle membrane, autophagic vacuole, autophagic vacuole membrane, cytoplasmic vesicle, cytosol, extrinsic to membrane, membrane, pre-autophagosomal structure, vacuolar membrane, vacuole	molecular_function		
YBL079W	NUP170	Subunit of the nuclear pore complex (NPC), required for NPC localization of specific nucleoporins; involved in nuclear envelope permeability and chromosome segregation; has similar to Nup157p; essential role, with Nup157p, in NPC assembly [Source:SGD;Acc:S000000175]	NLS-bearing substrate import into nucleus, chromosome segregation, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport, protein export from nucleus, protein import into nucleus, docking, protein targeting to membrane, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	integral to membrane, karyopherin docking complex, membrane, nuclear membrane, nuclear pore, nucleus	structural constituent of nuclear pore, structural molecule activity		
YBL080C	PET112	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog [Source:SGD;Acc:S000000176]	glutaminyl-tRNAGln biosynthesis via transamidation, mitochondrial translation, translation	glutamyl-tRNA(Gln) amidotransferase complex, mitochondrion	ATP binding, carbon-nitrogen ligase activity, with glutamine as amido-N-donor, glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, ligase activity, nucleotide binding		
YBL081W	YBL081W	Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport [Source:SGD;Acc:S000000177]	biological_process	cellular_component	molecular_function		
YBL082C	ALG3	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins [Source:SGD;Acc:S000000178]	oligosaccharide-lipid intermediate biosynthetic process, protein glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	alpha-1,3-mannosyltransferase activity, dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups		
YBL083C	YBL083C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3 [Source:SGD;Acc:S000000179]					
YBL084C	CDC27	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000000180]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, cyclin catabolic process, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, protein ubiquitination	anaphase-promoting complex, cytoplasm, nucleus	binding, ubiquitin-protein ligase activity		
YBL085W	BOI1	Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain [Source:SGD;Acc:S000000181]	Rho protein signal transduction, budding cell apical bud growth, cytokinesis, completion of separation, establishment of cell polarity	cellular bud, cellular bud neck, mating projection tip, site of polarized growth	phospholipid binding, protein binding		
YBL086C	YBL086C	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000000182]	biological_process	cellular_component	molecular_function		
YBL087C	RPL23A	Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins [Source:SGD;Acc:S000000183]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YBL088C	TEL1	Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene [Source:SGD;Acc:S000000184]	DNA damage induced protein phosphorylation, DNA repair, chromatin modification, double-strand break repair, histone phosphorylation, phosphorylation, response to DNA damage stimulus, telomere maintenance	chromosome, telomeric region, mitochondrion, nucleus	ATP binding, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein kinase activity, protein serine/threonine kinase activity, telomeric DNA binding, transferase activity		
YBL089W	AVT5	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000000185]	amino acid transport, transport	cellular_component, integral to membrane, membrane, vacuolar membrane, vacuole	transporter activity		
YBL090W	MRP21	Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences [Source:SGD;Acc:S000000186]	mitochondrial translation, mitochondrial translational initiation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YBL091C	MAP2	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p [Source:SGD;Acc:S000000187]	cellular process, protein initiator methionine removal involved in protein maturation, proteolysis	cytoplasm	aminopeptidase activity, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metalloexopeptidase activity, peptidase activity		
YBL091C-A	SCS22	Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein [Source:SGD;Acc:S000007228]	phospholipid biosynthetic process	cellular_component, integral to membrane, membrane	molecular_function, structural molecule activity		
YBL092W	RPL32	Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing [Source:SGD;Acc:S000000188]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YBL093C	ROX3	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme [Source:SGD;Acc:S000000189]	positive regulation of transcription from RNA polymerase II promoter, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus			
YBL094C	YBL094C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W [Source:SGD;Acc:S000000190]					
YBL095W	YBL095W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000191]	biological_process	integral to membrane, membrane, mitochondrion	molecular_function		
YBL096C	YBL096C	Non-essential protein of unknown function [Source:SGD;Acc:S000000192]					
YBL097W	BRN1	Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission [Source:SGD;Acc:S000000193]	cell cycle, cell division, chromosome condensation, mitosis, mitotic cell cycle, mitotic chromosome condensation, mitotic sister chromatid segregation, tRNA gene clustering	SMC loading complex, chromosome, cytoplasm, nuclear condensin complex, nucleus	molecular_function		
YBL098W	BNA4	Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease [Source:SGD;Acc:S000000194]	de novo NAD biosynthetic process from tryptophan, metabolic process, oxidation-reduction process, pyridine nucleotide biosynthetic process	mitochondrial outer membrane, mitochondrion	kynurenine 3-monooxygenase activity, monooxygenase activity, oxidoreductase activity		
YBL099W	ATP1	Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [Source:SGD;Acc:S000000195]	ATP biosynthetic process, ATP hydrolysis coupled proton transport, ATP metabolic process, ATP synthesis coupled proton transport, ion transport, proton transport, transport	membrane, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrial proton-transporting ATP synthase, catalytic core, mitochondrion, proton-transporting ATP synthase complex, catalytic core F(1), proton-transporting two-sector ATPase complex, proton-transporting two-sector ATPase complex, catalytic domain	ATP binding, ATPase activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, nucleotide binding, proton-transporting ATPase activity, rotational mechanism		
YBL100C	YBL100C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1 [Source:SGD;Acc:S000000196]					
YBL100W-A	YBL100W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000002148]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YBL100W-B	YBL100W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000002149]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YBL100W-C	YBL100W-C	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028598]	biological_process	cellular_component	molecular_function		
YBL101C	ECM21	Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements [Source:SGD;Acc:S000000197]	cellular cell wall organization, fungal-type cell wall organization, ubiquitin-dependent endocytosis	cytoplasm	ubiquitin protein ligase binding		
YBL102W	SFT2	Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 [Source:SGD;Acc:S000000198]	Golgi to endosome transport, protein transport, transport, vesicle-mediated transport	Golgi apparatus, Golgi membrane, integral to membrane, membrane	molecular_function		
YBL103C	RTG3	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways [Source:SGD;Acc:S000000199]	mitochondria-nucleus signaling pathway, transcription initiation from RNA polymerase II promoter	cytoplasm, nucleus	DNA binding, sequence-specific DNA binding		
YBL104C	YBL104C	Putative protein of unknown function, promoter contains multiple GCN4 binding sites [Source:SGD;Acc:S000000200]	biological_process	cytoplasm	molecular_function, protein binding		
YBL105C	PKC1	Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) [Source:SGD;Acc:S000000201]	actin filament organization, cell cycle, cytoplasmic mRNA processing body assembly, fungal-type cell wall organization, intracellular protein kinase cascade, intracellular signal transduction, peroxisome degradation, protein phosphorylation, regulation of nuclear-transcribed mRNA poly(A) tail shortening, signal transduction	cytoplasm, cytoskeleton, intracellular, nucleus, plasma membrane enriched fraction, site of polarized growth	ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase C activity, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YBL106C	SRO77	Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p [Source:SGD;Acc:S000000202]	Golgi to plasma membrane transport, exocytosis	plasma membrane	molecular_function		
YBL107C	YBL107C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene [Source:SGD;Acc:S000000203]	biological_process	cytoplasm	molecular_function		
YBL107W-A	YBL107W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the Ty2 LTR YBLWdelta2 [Source:SGD;Acc:S000007229]					
YBL108C-A	PAU9	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000007592]	biological_process, response to stress	cellular_component	molecular_function		
YBL108W	YBL108W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000204]					
YBL109W	YBL109W	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000002150]					
YBL111C	YBL111C	Helicase-like protein encoded within the telomeric Y' element [Source:SGD;Acc:S000002151]	biological_process	cellular_component	ATP binding, ATP-dependent helicase activity, molecular_function, nucleic acid binding, nucleotide binding		
YBL112C	YBL112C	Putative protein of unknown function; YBL112C is contained within TEL02L [Source:SGD;Acc:S000002152]	biological_process	cellular_component	ATP binding, helicase activity, molecular_function, nucleic acid binding		
YBL113C	YBL113C	Helicase-like protein encoded within the telomeric Y' element [Source:SGD;Acc:S000002153]	biological_process	cellular_component	helicase activity		
YBL113W-A	YBL113W-A	Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028599]					
YBR001C	NTH2	Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses [Source:SGD;Acc:S000000205]	metabolic process, trehalose catabolic process, trehalose metabolic process	cytoplasm, mitochondrion	alpha,alpha-trehalase activity, calcium ion binding, catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds		
YBR002C	RER2	Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting [Source:SGD;Acc:S000000206]	ER to Golgi vesicle-mediated transport, dolichol biosynthetic process, protein glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, membrane	dehydrodolichyl diphosphate synthase activity, prenyltransferase activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups		
YBR003W	COQ1	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis [Source:SGD;Acc:S000000207]	isoprenoid biosynthetic process, ubiquinone biosynthetic process	membrane, mitochondrial inner membrane, mitochondrion	metal ion binding, trans-hexaprenyltranstransferase activity, transferase activity		
YBR004C	GPI18	Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria [Source:SGD;Acc:S000000208]	GPI anchor biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, mannosyltransferase complex, membrane, mitochondrion	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups		
YBR005W	RCR1	Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane [Source:SGD;Acc:S000000209]	cellular cell wall organization, fungal-type cell wall organization, vesicle-mediated transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YBR006W	UGA2	Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm [Source:SGD;Acc:S000000210]	cellular response to oxidative stress, gamma-aminobutyric acid catabolic process, glutamate decarboxylation to succinate, metabolic process, oxidation-reduction process	cytoplasm	oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, succinate-semialdehyde dehydrogenase [NAD(P)+] activity		
YBR007C	DSF2	Deletion suppressor of mpt5 mutation [Source:SGD;Acc:S000000211]	biological_process	cellular_component	binding, molecular_function		
YBR008C	FLR1	Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000000212]	drug transmembrane transport, drug transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	drug transmembrane transporter activity, fluconazole transporter activity		
YBR009C	HHF1	Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity [Source:SGD;Acc:S000000213]	chromatin assembly or disassembly, histone H3-K79 methylation, nucleosome assembly, sexual sporulation resulting in formation of a cellular spore	chromosome, nuclear nucleosome, nucleosome, nucleus, replication fork protection complex	DNA binding		
YBR010W	HHT1	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation [Source:SGD;Acc:S000000214]	DNA repair, chromatin assembly or disassembly, mitotic cell cycle spindle assembly checkpoint, nucleosome assembly, rRNA transcription, response to DNA damage stimulus, sexual sporulation resulting in formation of a cellular spore	chromosome, nuclear nucleosome, nucleosome, nucleus, replication fork protection complex	DNA binding		
YBR011C	IPP1	Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase [Source:SGD;Acc:S000000215]	phosphate metabolic process	cytoplasm, cytosol	hydrolase activity, inorganic diphosphatase activity, magnesium ion binding, metal ion binding, protein homodimerization activity		
YBR012C	YBR012C	Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p [Source:SGD;Acc:S000000216]					
YBR012W-A	YBR012W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000002154]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YBR012W-B	YBR012W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000002155]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YBR013C	YBR013C	Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein [Source:SGD;Acc:S000000217]	biological_process	cellular_component	molecular_function		
YBR014C	GRX7	Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; functional overlap with GRX6 [Source:SGD;Acc:S000000218]	cell redox homeostasis, cellular response to oxidative stress	Golgi apparatus, Golgi lumen, cis-Golgi network, fungal-type vacuole, integral to membrane	2 iron, 2 sulfur cluster binding, electron carrier activity, glutathione-disulfide reductase activity, iron-sulfur cluster binding, metal ion binding, protein disulfide oxidoreductase activity, protein homodimerization activity		
YBR015C	MNN2	Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment [Source:SGD;Acc:S000000219]	protein glycosylation	Golgi apparatus, integral to membrane, membrane	alpha-1,2-mannosyltransferase activity		
YBR016W	YBR016W	Tail-anchored plasma membrane protein containing a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions [Source:SGD;Acc:S000000220]	biological_process	cellular bud membrane, mating projection membrane, plasma membrane	molecular_function		
YBR017C	KAP104	Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis [Source:SGD;Acc:S000000221]	cell cycle, mRNA-binding (hnRNP) protein import into nucleus, protein import into nucleus, protein transport, transcription factor import into nucleus, transport	cellular bud neck, cellular bud tip, cytoplasm, cytosol	binding, nuclear localization sequence binding		
YBR018C	GAL7	Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism [Source:SGD;Acc:S000000222]	carbohydrate metabolic process, galactose catabolic process via UDP-galactose, galactose metabolic process	cytoplasm	UDP-glucose:hexose-1-phosphate uridylyltransferase activity, catalytic activity, metal ion binding, nucleotidyltransferase activity, transferase activity, zinc ion binding		
YBR019C	GAL10	UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers [Source:SGD;Acc:S000000223]	carbohydrate metabolic process, cellular metabolic process, galactose catabolic process via UDP-galactose, galactose metabolic process, metabolic process	soluble fraction	UDP-glucose 4-epimerase activity, aldose 1-epimerase activity, binding, carbohydrate binding, catalytic activity, coenzyme binding, isomerase activity		
YBR020W	GAL1	Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p [Source:SGD;Acc:S000000224]	carbohydrate metabolic process, carbohydrate phosphorylation, galactose catabolic process via UDP-galactose, galactose metabolic process, metabolic process, phosphorylation, positive regulation of transcription by galactose	cytoplasm	ATP binding, galactokinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YBR021W	FUR4	Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues [Source:SGD;Acc:S000000225]	nucleobase, nucleoside, nucleotide and nucleic acid transport, transmembrane transport, transport, uracil transport	integral to membrane, membrane, membrane raft, plasma membrane	nucleobase transmembrane transporter activity, uracil:cation symporter activity		
YBR022W	POA1	Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing [Source:SGD;Acc:S000000226]	tRNA splicing, via endonucleolytic cleavage and ligation	cellular_component	hydrolase activity, phosphatase activity		
YBR023C	CHS3	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan [Source:SGD;Acc:S000000227]	ascospore wall assembly, cellular cell wall organization, cytokinesis, fungal-type cell wall chitin biosynthetic process	cellular bud neck, chitosome, cytoplasm, incipient cellular bud site, integral to membrane, mating projection tip, membrane, prospore membrane	chitin synthase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups		
YBR024W	SCO2	Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p [Source:SGD;Acc:S000000228]	cell redox homeostasis, cellular copper ion homeostasis, copper ion transport, respiratory chain complex IV assembly	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion	copper ion binding, metal ion binding, thioredoxin peroxidase activity		
YBR025C	OLA1	P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide [Source:SGD;Acc:S000000229]	biological_process	cytoplasm, intracellular	ATPase activity, GTP binding, nucleotide binding		
YBR026C	ETR1	2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis [Source:SGD;Acc:S000000230]	aerobic respiration, fatty acid biosynthetic process, lipid biosynthetic process, metabolic process, oxidation-reduction process	mitochondrial matrix, mitochondrion	DNA binding, binding, catalytic activity, enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity, enoyl-[acyl-carrier-protein] reductase activity, oxidoreductase activity, trans-2-enoyl-CoA reductase (NADPH) activity, zinc ion binding		
YBR027C	YBR027C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000231]					
YBR028C	YPK3	An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner [Source:SGD;Acc:S000000232]	biological_process, protein phosphorylation	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YBR029C	CDS1	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids [Source:SGD;Acc:S000000233]	phosphatidylglycerol biosynthetic process, phosphatidylserine metabolic process, phospholipid biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrial membrane, mitochondrion	nucleotidyltransferase activity, phosphatidate cytidylyltransferase activity, transferase activity, transferase activity, transferring phosphorus-containing groups		
YBR030W	RKM3	Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein [Source:SGD;Acc:S000000234]	peptidyl-lysine monomethylation	nucleus	methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity		
YBR031W	RPL4A	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins [Source:SGD;Acc:S000000235]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YBR032W	YBR032W	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000000236]					
YBR033W	EDS1	Putative zinc cluster protein; YBR033W is not an essential gene [Source:SGD;Acc:S000000237]	biological_process, regulation of transcription, DNA-dependent	cellular_component, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YBR034C	HMT1	Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p [Source:SGD;Acc:S000000238]	mRNA export from nucleus, negative regulation of transcription termination, DNA-dependent, peptidyl-arginine methylation, protein methylation	cytoplasm, nucleus	methyltransferase activity, protein methyltransferase activity, protein-arginine omega-N asymmetric methyltransferase activity, protein-arginine omega-N monomethyltransferase activity, transferase activity		
YBR035C	PDX3	Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism [Source:SGD;Acc:S000000239]	fatty acid metabolic process, oxidation-reduction process, pyridoxine biosynthetic process	cellular_component	FMN binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-NH2 group of donors, pyridoxamine-phosphate oxidase activity		
YBR036C	CSG2	Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations [Source:SGD;Acc:S000000240]	cellular calcium ion homeostasis, glycosphingolipid biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	enzyme regulator activity		
YBR037C	SCO1	Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins [Source:SGD;Acc:S000000241]	cellular copper ion homeostasis, copper ion transport, protein complex assembly, respiratory chain complex IV assembly, response to redox state	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	copper ion binding, metal ion binding, thioredoxin peroxidase activity		
YBR038W	CHS2	Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis [Source:SGD;Acc:S000000242]	cellular cell wall organization, chitin biosynthetic process, contractile ring contraction involved in cell cycle cytokinesis, cytokinesis	cellular bud neck, integral to membrane, membrane	chitin synthase activity, transferase activity, transferase activity, transferring glycosyl groups		
YBR039W	ATP3	Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis [Source:SGD;Acc:S000000243]	ATP biosynthetic process, ATP synthesis coupled proton transport, ion transport, proton transport, transport	membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase, central stalk, mitochondrion, proton-transporting ATP synthase complex, catalytic core F(1)	ATPase activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism		
YBR040W	FIG1	Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating [Source:SGD;Acc:S000000244]	cell morphogenesis involved in conjugation with cellular fusion, cytogamy	fungal-type cell wall, integral to membrane, mating projection tip, membrane	molecular_function		
YBR041W	FAT1	Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids [Source:SGD;Acc:S000000245]	lipid transport, long-chain fatty acid transport, metabolic process, transport, very long-chain fatty acid metabolic process	endoplasmic reticulum, integral to membrane, intrinsic to internal side of plasma membrane, lipid particle, membrane, peroxisome	catalytic activity, long-chain fatty acid transporter activity, very long-chain fatty acid-CoA ligase activity		
YBR042C	CST26	Protein required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed [Source:SGD;Acc:S000000246]	metabolic process, phospholipid biosynthetic process	integral to membrane, lipid particle, membrane	acyltransferase activity, transferase activity		
YBR043C	QDR3	Multidrug transporter of the major facilitator superfamily, has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin [Source:SGD;Acc:S000000247]	drug transmembrane transport, polyamine homeostasis, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	drug transmembrane transporter activity, polyamine transmembrane transporter activity		
YBR044C	TCM62	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone [Source:SGD;Acc:S000000248]	cellular protein metabolic process, mitochondrial respiratory chain complex II assembly, response to stress	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	ATP binding, nucleotide binding, unfolded protein binding		
YBR045C	GIP1	Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p [Source:SGD;Acc:S000000249]	ascospore wall assembly, regulation of phosphoprotein phosphatase activity	prospore membrane, protein phosphatase type 1 complex	protein phosphatase 1 binding, protein phosphatase type 1 regulator activity		
YBR046C	ZTA1	NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin [Source:SGD;Acc:S000000250]	cellular response to oxidative stress, metabolic process, oxidation-reduction process	cytoplasm, nucleus	2-alkenal reductase activity, AU-rich element binding, NADPH:quinone reductase activity, binding, catalytic activity, oxidoreductase activity, zinc ion binding		
YBR047W	FMP23	Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000251]	biological_process	mitochondrion	molecular_function		
YBR048W	RPS11B	Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins [Source:SGD;Acc:S000000252]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit assembly, translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YBR049C	REB1	RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription [Source:SGD;Acc:S000000253]	regulation of transcription from RNA polymerase II promoter, termination of RNA polymerase I transcription	nucleoplasm, nucleus	DNA binding, protein binding, sequence-specific DNA binding		
YBR050C	REG2	Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease [Source:SGD;Acc:S000000254]	negative regulation of transcription from RNA polymerase II promoter	protein phosphatase type 1 complex	protein phosphatase type 1 regulator activity		
YBR051W	YBR051W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase [Source:SGD;Acc:S000000255]					
YBR052C	RFS1	Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000000256]	biological_process	cytoplasm, membrane, membrane raft	FMN binding, molecular_function, oxidoreductase activity		
YBR053C	YBR053C	Putative protein of unknown function; induced by cell wall perturbation [Source:SGD;Acc:S000000257]	biological_process	cellular_component	molecular_function		
YBR054W	YRO2	Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p [Source:SGD;Acc:S000000258]	biological_process, ion transport	cellular bud, integral to membrane, membrane, mitochondrion	ion channel activity, molecular_function		
YBR055C	PRP6	Splicing factor, component of the U4/U6-U5 snRNP complex [Source:SGD;Acc:S000000259]	RNA processing, RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U4/U6 x U5 tri-snRNP complex, intracellular, nucleus	binding, molecular_function, protein binding		
YBR056C-B	YBR056C-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the dubious ORF YBR056W-A [Source:SGD;Acc:S000087087]					
YBR056W	YBR056W	Putative cytoplasmic protein of unknown function [Source:SGD;Acc:S000000260]	biological_process, carbohydrate metabolic process, metabolic process	cytoplasm	catalytic activity, cation binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, molecular_function		
YBR056W-A	YBR056W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B [Source:SGD;Acc:S000028736]					
YBR057C	MUM2	Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex [Source:SGD;Acc:S000000261]	meiosis, premeiotic DNA replication	cytoplasm	molecular_function		
YBR058C	UBP14	Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T [Source:SGD;Acc:S000000262]	negative regulation of gluconeogenesis, proteasomal ubiquitin-dependent protein catabolic process, protein deubiquitination, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus	cysteine-type peptidase activity, hydrolase activity, metal ion binding, omega peptidase activity, peptidase activity, protein binding, ubiquitin thiolesterase activity, ubiquitin-specific protease activity, zinc ion binding		
YBR058C-A	TSC3	Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis [Source:SGD;Acc:S000007521]	3-keto-sphinganine metabolic process, sphingolipid biosynthetic process	SPOTS complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, membrane fraction, microsome	enzyme activator activity		
YBR059C	AKL1	Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization [Source:SGD;Acc:S000000263]	actin cytoskeleton organization, protein phosphorylation, regulation of endocytosis	cellular bud neck, cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YBR060C	ORC2	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p [Source:SGD;Acc:S000000264]	DNA replication, DNA-dependent DNA replication initiation, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, histone H3-K4 methylation, pre-replicative complex assembly	DNA replication preinitiation complex, nuclear origin of replication recognition complex, nucleus, origin recognition complex, pre-replicative complex	DNA binding, DNA replication origin binding, chromatin binding		
YBR061C	TRM7	2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop [Source:SGD;Acc:S000000265]	methylation, rRNA methylation, tRNA methylation, tRNA processing, translation	cytoplasm	methyltransferase activity, nucleic acid binding, tRNA methyltransferase activity, transferase activity		
YBR062C	YBR062C	Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway. [Source:SGD;Acc:S000000266]	biological_process	cellular_component	metal ion binding, molecular_function, protein binding, zinc ion binding		
YBR063C	YBR063C	Putative protein of unknown function; YBR063C is not an essential gene [Source:SGD;Acc:S000000267]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YBR064W	YBR064W	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C [Source:SGD;Acc:S000000268]					
YBR065C	ECM2	Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p [Source:SGD;Acc:S000000269]	RNA splicing, fungal-type cell wall organization, mRNA processing, nuclear mRNA splicing, via spliceosome	nucleus, spliceosomal complex	RNA binding, molecular_function		
YBR066C	NRG2	Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p [Source:SGD;Acc:S000000270]	biofilm formation, invasive growth in response to glucose limitation, pseudohyphal growth	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YBR067C	TIP1	Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins [Source:SGD;Acc:S000000271]	fungal-type cell wall organization, response to stress	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	hydrolase activity, lipase activity, structural constituent of cell wall		
YBR068C	BAP2	High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains [Source:SGD;Acc:S000000272]	amino acid transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	amino acid transmembrane transporter activity		
YBR069C	TAT1	Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance [Source:SGD;Acc:S000000273]	amino acid transport, transmembrane transport, transport, tryptophan transport, tyrosine transport	integral to membrane, membrane, plasma membrane	amino acid transmembrane transporter activity, low-affinity tryptophan transmembrane transporter activity		
YBR070C	ALG14	Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases [Source:SGD;Acc:S000000274]	dolichol-linked oligosaccharide biosynthetic process	UDP-N-acetylglucosamine transferase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, intrinsic to endoplasmic reticulum membrane, membrane, membrane fraction, nuclear membrane, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity, protein anchor		
YBR071W	YBR071W	Putative protein of unknown function; (GFP)-fusion and epitope-tagged proteins localize to the cytoplasm; mRNA expression may be regulated by the cell cycle and/or cell wall stress [Source:SGD;Acc:S000000275]	biological_process	cytoplasm	molecular_function		
YBR072C-A	YBR072C-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028532]	biological_process	cellular_component	molecular_function		
YBR072W	HSP26	Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity [Source:SGD;Acc:S000000276]	protein folding, response to stress	cytoplasm, nucleus	mRNA binding, unfolded protein binding		
YBR073W	RDH54	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference [Source:SGD;Acc:S000000277]	DNA geometric change, DNA recombination, DNA repair, double-strand break repair via break-induced replication, heteroduplex formation, meiosis, meiotic sister chromatid segregation, reciprocal meiotic recombination, response to DNA damage stimulus	nucleus	ATP binding, DNA binding, DNA topoisomerase activity, DNA translocase activity, DNA-dependent ATPase activity, helicase activity, hydrolase activity, isomerase activity, nucleic acid binding, nucleotide binding		
YBR074W	YBR074W	Putative metalloprotease [Source:SGD;Acc:S000000278]	biological_process, proteolysis	cellular_component, integral to membrane, membrane	hydrolase activity, metallopeptidase activity, molecular_function, peptidase activity		
YBR076C-A	YBR076C-A	Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028533]					
YBR076W	ECM8	Non-essential protein of unknown function [Source:SGD;Acc:S000000280]	cellular cell wall organization, fungal-type cell wall organization	cellular_component	molecular_function		
YBR077C	SLM4	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 [Source:SGD;Acc:S000000281]	autophagy, microautophagy, protein transport, signal transduction, transport	EGO complex, GSE complex, cytoplasm, fungal-type vacuole membrane, integral to membrane, late endosome membrane, membrane, vacuolar membrane, vacuole	phosphatidylinositol-3,4-bisphosphate binding		
YBR078W	ECM33	GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p [Source:SGD;Acc:S000000282]	cellular cell wall organization, fungal-type cell wall organization	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane, membrane fraction, mitochondrion, plasma membrane, plasma membrane enriched fraction	molecular_function		
YBR079C	RPG1	eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation [Source:SGD;Acc:S000000283]	translation, translational initiation	cytoplasm, eukaryotic translation initiation factor 3 complex, incipient cellular bud site, stress granule	protein binding, translation initiation factor activity		
YBR080C	SEC18	ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF [Source:SGD;Acc:S000000284]	Golgi to plasma membrane protein transport, Golgi vesicle docking, SNARE complex disassembly, autophagic vacuole assembly, inter-Golgi cisterna vesicle-mediated transport, protein transport, transport, vacuole fusion, non-autophagic, vesicle fusion with Golgi apparatus, vesicle-mediated transport	cytoplasm, mating projection tip	ATP binding, ATPase activity, binding, nucleoside-triphosphatase activity, nucleotide binding		
YBR081C	SPT7	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex [Source:SGD;Acc:S000000285]	chromatin modification, conjugation with cellular fusion, histone acetylation, protein complex assembly	SAGA complex, SLIK (SAGA-like) complex, mitochondrion, nucleus	protein binding, structural molecule activity		
YBR082C	UBC4	Ubiquitin-conjugating enzyme (E2), mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response [Source:SGD;Acc:S000000286]	post-translational protein modification, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of protein metabolic process, response to stress, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	proteasome complex	ATP binding, acid-amino acid ligase activity, ligase activity, nucleotide binding, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YBR083W	TEC1	Transcription factor required for full Ty1 expression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member [Source:SGD;Acc:S000000287]	invasive growth in response to glucose limitation, positive regulation of transcription from RNA polymerase II promoter, pseudohyphal growth, regulation of transcription, DNA-dependent	nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YBR084C-A	RPL19A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal [Source:SGD;Acc:S000002156]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YBR084W	MIS1	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase [Source:SGD;Acc:S000000288]	cellular amino acid biosynthetic process, folic acid biosynthetic process, folic acid-containing compound biosynthetic process, histidine biosynthetic process, metabolic process, methionine biosynthetic process, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, one-carbon metabolic process, oxidation-reduction process, purine nucleotide biosynthetic process	mitochondrion	ATP binding, binding, catalytic activity, formate-tetrahydrofolate ligase activity, hydrolase activity, ligase activity, methenyltetrahydrofolate cyclohydrolase activity, methionyl-tRNA formyltransferase activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, nucleotide binding, oxidoreductase activity		
YBR085C-A	YBR085C-A	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus [Source:SGD;Acc:S000007522]	biological_process	cytoplasm, nucleus	molecular_function		
YBR085W	AAC3	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration [Source:SGD;Acc:S000000289]	anaerobic respiration, heme biosynthetic process, heme transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	ATP:ADP antiporter activity, binding, transporter activity		
YBR086C	IST2	Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process [Source:SGD;Acc:S000000290]	response to osmotic stress	cellular bud membrane, integral to membrane, membrane, plasma membrane	lipid binding		
YBR087W	RFC5	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [Source:SGD;Acc:S000000291]	DNA replication, cell cycle, leading strand elongation, mismatch repair, sister chromatid cohesion	Ctf18 RFC-like complex, DNA replication factor C complex, Elg1 RFC-like complex, Rad17 RFC-like complex, nucleus	ATP binding, DNA binding, DNA clamp loader activity, nucleoside-triphosphatase activity, nucleotide binding		
YBR088C	POL30	Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair [Source:SGD;Acc:S000000292]	DNA repair, DNA replication, base-excision repair, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, lagging strand elongation, leading strand elongation, meiotic mismatch repair, mismatch repair, mitotic sister chromatid cohesion, nucleotide-excision repair, postreplication repair, regulation of DNA replication, response to DNA damage stimulus	PCNA complex, nucleus, replication fork	DNA binding, DNA polymerase processivity factor activity		
YBR089C-A	NHP6B	High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2 [Source:SGD;Acc:S000002157]	DNA repair, RNA polymerase III transcriptional preinitiation complex assembly, chromatin remodeling, response to DNA damage stimulus, transcription from RNA polymerase II promoter	chromosome, nucleus	DNA bending activity, DNA binding, nucleosome binding, protein binding, sequence-specific DNA binding		
YBR089W	YBR089W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30 [Source:SGD;Acc:S000000293]					
YBR090C	YBR090C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000000294]	biological_process	cytoplasm, integral to membrane, membrane, nucleus	molecular_function		
YBR091C	TIM12	Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins [Source:SGD;Acc:S000000295]	protein import into mitochondrial inner membrane, protein targeting to mitochondrion, protein transport, transmembrane transport, transport	membrane, mitochondrial inner membrane, mitochondrial inner membrane protein insertion complex, mitochondrial intermembrane space protein transporter complex, mitochondrion	metal ion binding, phospholipid binding, protein channel activity		
YBR092C	PHO3	Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin [Source:SGD;Acc:S000000296]	phosphate metabolic process, thiamine-containing compound metabolic process	cell wall-bounded periplasmic space	acid phosphatase activity, hydrolase activity, phosphatase activity		
YBR093C	PHO5	Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 [Source:SGD;Acc:S000000297]	cellular response to phosphate starvation, phosphate metabolic process, regulation of cell size	cell wall-bounded periplasmic space, extracellular region, fungal-type cell wall	acid phosphatase activity, hydrolase activity, nucleoside-triphosphatase activity, nucleoside-triphosphate diphosphatase activity, phosphatase activity		
YBR094W	PBY1	Putative tubulin tyrosine ligase associated with P-bodies [Source:SGD;Acc:S000000298]	biological_process, protein modification process	cytoplasm, cytoplasmic mRNA processing body	ATP binding, catalytic activity, hydrolase activity, molecular_function, tubulin-tyrosine ligase activity		
YBR095C	RXT2	Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth [Source:SGD;Acc:S000000299]	chromatin modification, conjugation with cellular fusion, histone deacetylation, invasive growth in response to glucose limitation, negative regulation of chromatin silencing at telomere, negative regulation of transcription from RNA polymerase II promoter	Rpd3L complex, Rpd3L-Expanded complex, nucleus	histone deacetylase activity		
YBR096W	YBR096W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER [Source:SGD;Acc:S000000300]	biological_process	endoplasmic reticulum	molecular_function		
YBR097W	VPS15	Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p [Source:SGD;Acc:S000000301]	inositol lipid-mediated signaling, late endosome to vacuole transport, macroautophagy, peroxisome degradation, protein phosphorylation, protein retention in Golgi apparatus, protein targeting to vacuole, protein transport, transport, vacuole inheritance	Golgi apparatus, Golgi membrane, endosome, endosome membrane, membrane, mitochondrion, phosphatidylinositol 3-kinase complex I, phosphatidylinositol 3-kinase complex II	ATP binding, binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, ubiquitin binding		
YBR098W	MMS4	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination [Source:SGD;Acc:S000000302]	DNA metabolic process, DNA recombination, DNA repair, DNA topological change, meiosis, reciprocal meiotic recombination, regulation of reciprocal meiotic recombination, resolution of meiotic recombination intermediates, response to DNA damage stimulus	Holliday junction resolvase complex, nucleus	DNA binding, crossover junction endodeoxyribonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, transcription coactivator activity		
YBR099C	YBR099C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 [Source:SGD;Acc:S000000303]					
YBR101C	FES1	Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum [Source:SGD;Acc:S000000305]	regulation of translation, translation	cytoplasm, cytosol, cytosolic ribosome	adenyl-nucleotide exchange factor activity, binding		
YBR102C	EXO84	Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis [Source:SGD;Acc:S000000306]	exocytosis, protein transport, spliceosome assembly, transport	cellular bud, cellular bud neck, cellular bud tip, cytoplasmic vesicle, exocyst, incipient cellular bud site, mating projection tip, transport vesicle	molecular_function		
YBR103C-A	YBR103C-A	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; identified by homology to related yeast [Source:SGD;Acc:S000007593]					
YBR103W	SIF2	WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus [Source:SGD;Acc:S000000307]	chromatin modification, histone deacetylation, negative regulation of chromatin silencing at telomere, negative regulation of meiosis, positive regulation of stress-activated MAPK cascade	Rpd3L-Expanded complex, Set3 complex, nucleus	molecular_function, protein binding		
YBR104W	YMC2	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p [Source:SGD;Acc:S000000308]	mitochondrial transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, organic acid transmembrane transporter activity		
YBR105C	VID24	Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase [Source:SGD;Acc:S000000309]	negative regulation of gluconeogenesis, proteasomal ubiquitin-dependent protein catabolic process, protein targeting to vacuole, protein transport, transport, vacuolar protein catabolic process, vesicle fusion with vacuole, vesicle-mediated transport	GID complex, cytoplasmic membrane-bounded vesicle, cytoplasmic vesicle, cytoplasmic vesicle membrane, extrinsic to membrane, membrane	molecular_function		
YBR106W	PHO88	Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations [Source:SGD;Acc:S000000310]	phosphate transport, transport	integral to membrane, membrane, mitochondrion	molecular_function		
YBR107C	IML3	Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p [Source:SGD;Acc:S000000311]	ascospore formation, cell cycle, cell division, chromosome segregation, establishment of meiotic sister chromatid cohesion, establishment of mitotic sister chromatid cohesion, maintenance of meiotic sister chromatid cohesion, meiosis, meiotic sister chromatid segregation, mitosis, protein localization to chromosome, centromeric region	chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome outer kinetochore, kinetochore, nucleus	molecular_function		
YBR108W	AIM3	Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000000312]	actin cortical patch assembly	actin cortical patch, membrane, membrane raft	molecular_function		
YBR109C	CMD1	Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin [Source:SGD;Acc:S000000313]	NLS-bearing substrate import into nucleus, cell budding, cytoskeleton organization, karyogamy involved in conjugation with cellular fusion, microautophagy, phosphatidylinositol biosynthetic process, receptor-mediated endocytosis, spindle pole body organization, transcription factor import into nucleus, vacuole fusion, non-autophagic	cellular bud neck, cellular bud tip, central plaque of spindle pole body, incipient cellular bud site, mating projection tip	calcium ion binding, calcium-dependent protein binding, protein binding		
YBR109W-A	YBR109W-A	Putative protein of unknown function; questionable ORF from MIPS [Source:SGD;Acc:S000028737]					
YBR110W	ALG1	Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog [Source:SGD;Acc:S000000314]	biosynthetic process, oligosaccharide-lipid intermediate biosynthetic process, protein N-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	beta-1,4-mannosyltransferase activity, chitobiosyldiphosphodolichol beta-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YBR111C	YSA1	Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate [Source:SGD;Acc:S000000315]	ribose phosphate metabolic process	cytoplasm, mitochondrion, nucleus	ADP-ribose diphosphatase activity, hydrolase activity, metal ion binding		
YBR111W-A	SUS1	Protein involved in mRNA export coupled transcription activation and elongation; component of both the SAGA histone acetylase complex and TREX-2, and interacts with RNAPII [Source:SGD;Acc:S000028510]	chromatin modification, histone deubiquitination, mRNA export from nucleus, mRNA transport, positive regulation of transcription from RNA polymerase II promoter, protein transport, regulation of protein localization, transcription elongation from RNA polymerase II promoter, transmembrane transport, transport	DUBm complex, SAGA complex, nuclear pore, nucleoplasm, nucleus, transcription export complex 2	enzyme activator activity		
YBR112C	CYC8	General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+] [Source:SGD;Acc:S000000316]	chromatin remodeling, nucleosome positioning	nucleus, transcriptional repressor complex	binding, protein binding, transcription coactivator activity		
YBR113W	YBR113W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 [Source:SGD;Acc:S000000317]					
YBR114W	RAD16	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex [Source:SGD;Acc:S000000318]	DNA repair, nucleotide-excision repair, DNA damage recognition, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, response to DNA damage stimulus	Cul3-RING ubiquitin ligase complex, nucleotide-excision repair factor 4 complex, nucleus	ATP binding, DNA binding, DNA-dependent ATPase activity, damaged DNA binding, helicase activity, hydrolase activity, metal ion binding, nucleic acid binding, nucleotide binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YBR115C	LYS2	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p [Source:SGD;Acc:S000000319]	cellular amino acid biosynthetic process, lysine biosynthetic process, lysine biosynthetic process via aminoadipic acid, metabolic process, oxidation-reduction process	cytoplasm	L-aminoadipate-semialdehyde dehydrogenase activity, acyl carrier activity, binding, catalytic activity, cofactor binding, ligase activity, oxidoreductase activity, phosphopantetheine binding		
YBR116C	YBR116C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2 [Source:SGD;Acc:S000000320]					
YBR117C	TKL2	Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids [Source:SGD;Acc:S000000321]	metabolic process, pentose-phosphate shunt	cytoplasm, nucleus	catalytic activity, metal ion binding, transferase activity, transketolase activity		
YBR118W	TEF2	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus [Source:SGD;Acc:S000000322]	tRNA export from nucleus, translation, translational elongation	cytoplasm, cytoskeleton, eukaryotic translation elongation factor 1 complex, ribosome	GDP binding, GTP binding, GTPase activity, actin binding, nucleotide binding, translation elongation factor activity		
YBR119W	MUD1	U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing [Source:SGD;Acc:S000000323]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, nucleus, ribonucleoprotein complex, spliceosomal complex	RNA binding, U1 snRNA binding, nucleic acid binding, nucleotide binding		
YBR120C	CBP6	Mitochondrial translational activator of the COB mRNA; phosphorylated [Source:SGD;Acc:S000000324]	mRNA processing, translation	mitochondrion	molecular_function		
YBR121C	GRS1	Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation [Source:SGD;Acc:S000000325]	glycyl-tRNA aminoacylation, mitochondrial glycyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, transcription termination, DNA-dependent, translation	cytoplasm, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, glycine-tRNA ligase activity, ligase activity, nucleotide binding		
YBR121C-A	YBR121C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely contianed within the verified gene GRS1; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028815]					
YBR122C	MRPL36	Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region [Source:SGD;Acc:S000000326]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YBR123C	TFC1	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 [Source:SGD;Acc:S000000327]	transcription initiation from RNA polymerase III promoter	nucleus, transcription factor TFIIIC complex	DNA binding		
YBR124W	YBR124W	Putative protein of unknown function [Source:SGD;Acc:S000000328]					
YBR125C	PTC4	Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity [Source:SGD;Acc:S000000329]	biological_process, protein dephosphorylation	cytoplasm, protein serine/threonine phosphatase complex	catalytic activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YBR126C	TPS1	Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway [Source:SGD;Acc:S000000330]	cellular carbohydrate metabolic process, response to stress, trehalose biosynthetic process	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming), cytoplasm	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, catalytic activity, transferase activity, transferase activity, transferring glycosyl groups		
YBR126W-A	YBR126W-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches [Source:SGD;Acc:S000028600]					
YBR126W-B	YBR126W-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-A; Identified by SAGE [Source:SGD;Acc:S000028738]					
YBR127C	VMA2	Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm [Source:SGD;Acc:S000000331]	ATP hydrolysis coupled proton transport, ATP metabolic process, ATP synthesis coupled proton transport, cellular calcium ion homeostasis, ion transport, proton transport, transmembrane transport, transport, vacuolar acidification	cytoplasm, fungal-type vacuole membrane, proton-transporting V-type ATPase, V1 domain, proton-transporting two-sector ATPase complex, proton-transporting two-sector ATPase complex, catalytic domain, vacuolar proton-transporting V-type ATPase, V1 domain	ATP binding, hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, proton-transporting ATPase activity, rotational mechanism		
YBR128C	ATG14	Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; homolog of human Barkor [Source:SGD;Acc:S000000332]	CVT pathway, ER-associated protein catabolic process, autophagy, macroautophagy, peroxisome degradation, piecemeal microautophagy of nucleus, protein transport, transport	fungal-type vacuole membrane, membrane, peripheral to membrane of membrane fraction, phosphatidylinositol 3-kinase complex I, pre-autophagosomal structure	1-phosphatidylinositol-3-kinase activity		
YBR129C	OPY1	Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000333]	biological_process	cytoplasm, mitochondrion	molecular_function, protein binding		
YBR130C	SHE3	Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance [Source:SGD;Acc:S000000334]	endoplasmic reticulum inheritance, intracellular mRNA localization, mating type switching	actin cap, cellular bud tip, cytoplasm	mRNA binding		
YBR131C-A	YBR131C-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR131W. Identified by gene-trapping, microarray analysis, and genome-wide homology searches [Source:SGD;Acc:S000028601]					
YBR131W	CCZ1	Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway [Source:SGD;Acc:S000000335]	autophagic vacuole fusion, autophagy, protein targeting to vacuole, protein transport, transport, vacuolar transport, vesicle docking	Mon1-Ccz1 complex, endosome, late endosome membrane, membrane, multivesicular body membrane, vacuolar membrane, vacuole	guanyl-nucleotide exchange factor activity		
YBR132C	AGP2	High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease [Source:SGD;Acc:S000000336]	amino acid transport, carnitine transport, fatty acid metabolic process, polyamine transport, response to osmotic stress, transmembrane transport, transport	endoplasmic reticulum membrane, integral to membrane, integral to plasma membrane, membrane, vacuolar membrane	amino acid transmembrane transporter activity, carnitine transporter activity, polyamine transmembrane transporter activity		
YBR133C	HSL7	Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p [Source:SGD;Acc:S000000337]	G2/M transition of mitotic cell cycle, cell cycle, cell division, mitosis, regulation of cell cycle	cellular bud neck, cytoplasm	histone-arginine N-methyltransferase activity, methyltransferase activity, protein-arginine omega-N monomethyltransferase activity, protein-arginine omega-N symmetric methyltransferase activity, transferase activity		
YBR134W	YBR134W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000338]					
YBR135W	CKS1	Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters [Source:SGD;Acc:S000000339]	cell cycle, cell division, chromatin remodeling, positive regulation of transcription, DNA-dependent, regulation of cell cycle	cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus	cyclin-dependent protein kinase regulator activity, histone binding, protein kinase activator activity, ubiquitin binding		
YBR136W	MEC1	Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination [Source:SGD;Acc:S000000340]	DNA damage checkpoint, DNA damage induced protein phosphorylation, DNA recombination, DNA repair, DNA replication, chromatin modification, histone phosphorylation, meiosis, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, reciprocal meiotic recombination, response to DNA damage stimulus, telomere maintenance, telomere maintenance via recombination	mitochondrion, nucleus	ATP binding, binding, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YBR137W	YBR137W	Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene [Source:SGD;Acc:S000000341]	biological_process	TRC complex, cytoplasm	molecular_function		
YBR138C	YBR138C	Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene [Source:SGD;Acc:S000000342]	biological_process	cytoplasm	molecular_function		
YBR139W	YBR139W	Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner [Source:SGD;Acc:S000000343]	phytochelatin biosynthetic process, proteolysis	fungal-type vacuole	carboxypeptidase activity, hydrolase activity, peptidase activity, serine hydrolase activity, serine-type carboxypeptidase activity		
YBR140C	IRA1	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase [Source:SGD;Acc:S000000344]	negative regulation of Ras protein signal transduction, negative regulation of cAMP biosynthetic process, positive regulation of Ras GTPase activity, regulation of adenylate cyclase activity, regulation of small GTPase mediated signal transduction, signal transduction	cytoplasm, intracellular, membrane, mitochondrion	GTPase activator activity, Ras GTPase activator activity		
YBR141C	YBR141C	Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene [Source:SGD;Acc:S000000345]	biological_process	nucleolus, nucleus	S-adenosylmethionine-dependent methyltransferase activity		
YBR141W-A	YBR141W-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YBR141C; identified by gene-trapping, microarray analysis, and genome-wide homology searching [Source:SGD;Acc:S000028602]					
YBR142W	MAK5	Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits [Source:SGD;Acc:S000000346]	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis	nucleolus, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YBR143C	SUP45	Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin [Source:SGD;Acc:S000000347]	cytokinesis, translation, translational termination	cytoplasm, cytosol, translation release factor complex	translation release factor activity, translation release factor activity, codon specific		
YBR144C	YBR144C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene [Source:SGD;Acc:S000000348]					
YBR145W	ADH5	Alcohol dehydrogenase isoenzyme V; involved in ethanol production [Source:SGD;Acc:S000000349]	NADH oxidation, amino acid catabolic process to alcohol via Ehrlich pathway, ethanol biosynthetic process involved in glucose fermentation to ethanol, metabolic process, oxidation-reduction process	cytoplasm, nucleus	alcohol dehydrogenase (NAD) activity, binding, catalytic activity, metal ion binding, oxidoreductase activity, zinc ion binding		
YBR146W	MRPS9	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000000350]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YBR147W	RTC2	Protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; detected in highly purified mitochondria; null mutant suppresses cdc13-1; similar to a G-protein coupled receptor from S. pombe [Source:SGD;Acc:S000000351]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YBR148W	YSW1	Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane [Source:SGD;Acc:S000000352]	ascospore-type prospore membrane assembly	prospore membrane	molecular_function		
YBR149W	ARA1	NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product [Source:SGD;Acc:S000000353]	cellular carbohydrate metabolic process, oxidation-reduction process	cytoplasm, cytosol	D-arabinose 1-dehydrogenase [NAD(P)+] activity, alditol:NADP+ 1-oxidoreductase activity, oxidoreductase activity		
YBR150C	TBS1	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000354]	biological_process, regulation of transcription, DNA-dependent	cytoplasm, integral to membrane, membrane, mitochondrial membrane, mitochondrion, nuclear membrane, nucleus	DNA binding, binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YBR151W	APD1	Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus [Source:SGD;Acc:S000000355]	biological_process	cytoplasm, nucleus	molecular_function		
YBR152W	SPP381	mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p [Source:SGD;Acc:S000000356]	RNA splicing, generation of catalytic spliceosome for first transesterification step, mRNA processing, nuclear mRNA splicing, via spliceosome	U4/U6 x U5 tri-snRNP complex, nucleus, ribonucleoprotein complex, spliceosomal complex	RNA binding, molecular_function		
YBR153W	RIB7	Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway [Source:SGD;Acc:S000000357]	oxidation-reduction process, riboflavin biosynthetic process	cellular_component	5-amino-6-(5-phosphoribosylamino)uracil reductase activity, NADP binding, oxidoreductase activity		
YBR154C	RPB5	RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation [Source:SGD;Acc:S000000358]	tRNA transcription from RNA polymerase III promoter, transcription from RNA polymerase I promoter, transcription from RNA polymerase II promoter, transcription from RNA polymerase III promoter	DNA-directed RNA polymerase I complex, DNA-directed RNA polymerase II, core complex, DNA-directed RNA polymerase III complex, nucleus	DNA binding, DNA-directed RNA polymerase activity		
YBR155W	CNS1	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion [Source:SGD;Acc:S000000359]	protein folding	cytoplasm	Hsp70 protein binding, Hsp90 protein binding, binding, protein binding		
YBR156C	SLI15	Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly [Source:SGD;Acc:S000000360]	chromosome segregation, protein phosphorylation, regulation of cytokinesis	chromosome passenger complex, chromosome, centromeric region, condensed chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, kinetochore microtubule, nucleus, spindle, spindle microtubule, spindle midzone	protein kinase activator activity		
YBR157C	ICS2	Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization [Source:SGD;Acc:S000000361]	biological_process	cellular_component	molecular_function		
YBR158W	AMN1	Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) [Source:SGD;Acc:S000000362]	cell cycle, cell division, mitosis, mitotic cell cycle checkpoint, negative regulation of exit from mitosis	cellular bud, cytoplasm, nucleus	protein binding		
YBR159W	IFA38	Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides [Source:SGD;Acc:S000000363]	fatty acid biosynthetic process, fatty acid elongation, lipid biosynthetic process, metabolic process, oxidation-reduction process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	binding, catalytic activity, ketoreductase activity, oxidoreductase activity		
YBR160W	CDC28	Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates [Source:SGD;Acc:S000000364]	cell cycle, cell division, chromatin remodeling, mitosis, negative regulation of meiotic cell cycle, negative regulation of mitotic cell cycle, negative regulation of transcription, DNA-dependent, positive regulation of DNA replication involved in S phase, positive regulation of meiotic cell cycle, positive regulation of mitotic cell cycle, positive regulation of spindle pole body separation, positive regulation of transcription, DNA-dependent, positive regulation of triglyceride catabolic process, protein phosphorylation, regulation of budding cell apical bud growth, regulation of double-strand break repair via homologous recombination, regulation of filamentous growth	astral microtubule, cellular bud neck, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, endoplasmic reticulum, nucleus, ribosome, spindle pole body	ATP binding, cyclin-dependent protein kinase activity, histone binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YBR161W	CSH1	Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p [Source:SGD;Acc:S000000365]	glycosphingolipid biosynthetic process, sphingolipid biosynthetic process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YBR162C	TOS1	Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C [Source:SGD;Acc:S000000366]	biological_process	extracellular region, fungal-type cell wall, fungal-type vacuole	molecular_function		
YBR162W-A	YSY6	Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion [Source:SGD;Acc:S000002158]	protein secretion, protein transport, transmembrane transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YBR163W	EXO5	Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 [Source:SGD;Acc:S000000367]	mitochondrial genome maintenance, regulation of cell shape	mitochondrion	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity		
YBR164C	ARL1	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor [Source:SGD;Acc:S000000368]	Golgi to plasma membrane protein transport, protein targeting to vacuole, protein transport, small GTPase mediated signal transduction, transport, vesicle-mediated transport	Golgi apparatus, cytosol, intracellular, soluble fraction, trans-Golgi network	GTP binding, GTPase activity, nucleotide binding		
YBR165W	UBS1	Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity [Source:SGD;Acc:S000000369]	protein export from nucleus, protein ubiquitination	nucleus	molecular_function		
YBR166C	TYR1	Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels [Source:SGD;Acc:S000000370]	aromatic amino acid family biosynthetic process, cellular amino acid biosynthetic process, metabolic process, oxidation-reduction process, tyrosine biosynthetic process, tyrosine metabolic process	cytoplasm	binding, catalytic activity, oxidoreductase activity, prephenate dehydrogenase (NADP+) activity, prephenate dehydrogenase activity		
YBR167C	POP7	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends [Source:SGD;Acc:S000000371]	intronic box C/D snoRNA processing, mRNA cleavage, rRNA processing, tRNA processing	nucleolar ribonuclease P complex, nucleus, ribonuclease MRP complex	hydrolase activity, ribonuclease MRP activity, ribonuclease P activity		
YBR168W	PEX32	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p [Source:SGD;Acc:S000000372]	peroxisome organization	integral to membrane, integral to peroxisomal membrane, membrane, peroxisomal membrane, peroxisome	molecular_function		
YBR169C	SSE2	Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p [Source:SGD;Acc:S000000373]	protein folding, protein refolding, response to stress	cytoplasm	ATP binding, adenyl-nucleotide exchange factor activity, calmodulin binding, nucleotide binding		
YBR170C	NPL4	Ubiquitin-binding protein involved in protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD) [Source:SGD;Acc:S000000374]	ER-associated protein catabolic process, cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process, mRNA transport, mitochondria-associated protein catabolic process, protein transport, transmembrane transport, transport	Cdc48p-Npl4p-Ufd1p AAA ATPase complex, Doa10p ubiquitin ligase complex, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus, perinuclear region of cytoplasm	polyubiquitin binding		
YBR171W	SEC66	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER [Source:SGD;Acc:S000000375]	filamentous growth, posttranslational protein targeting to membrane, translocation, protein transport, transport	Sec62/Sec63 complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	protein transporter activity		
YBR172C	SMY2	Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2 [Source:SGD;Acc:S000000376]	ER to Golgi vesicle-mediated transport	cytoplasm, endoplasmic reticulum membrane, extrinsic to membrane	molecular_function, protein binding		
YBR173C	UMP1	Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly [Source:SGD;Acc:S000000377]	proteasome assembly, response to DNA damage stimulus, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus, proteasome complex	molecular_function		
YBR174C	YBR174C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective [Source:SGD;Acc:S000000378]					
YBR175W	SWD3	Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 [Source:SGD;Acc:S000000379]	chromatin silencing at telomere, histone H3-K4 methylation, telomere maintenance	Set1C/COMPASS complex, chromosome, telomeric region, nucleus	histone methyltransferase activity (H3-K4 specific), protein binding		
YBR176W	ECM31	Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate [Source:SGD;Acc:S000000380]	pantothenate biosynthetic process	mitochondrion	3-methyl-2-oxobutanoate hydroxymethyltransferase activity, catalytic activity, methyltransferase activity, transferase activity		
YBR177C	EHT1	Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane [Source:SGD;Acc:S000000381]	cellular lipid metabolic process, medium-chain fatty acid biosynthetic process, medium-chain fatty acid catabolic process	lipid particle, mitochondrial outer membrane, mitochondrion	acyltransferase activity, alcohol O-acetyltransferase activity, alcohol O-butanoyltransferase activity, carboxylesterase activity, hydrolase activity, serine hydrolase activity, short-chain carboxylesterase activity, transferase activity		
YBR178W	YBR178W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C [Source:SGD;Acc:S000000382]					
YBR179C	FZO1	Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system [Source:SGD;Acc:S000000383]	mitochondrial fusion	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion	GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein homodimerization activity		
YBR180W	DTR1	Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters [Source:SGD;Acc:S000000384]	amine transport, ascospore wall assembly, sporulation resulting in formation of a cellular spore, transmembrane transport, transport	integral to membrane, membrane, prospore membrane	amine transmembrane transporter activity		
YBR181C	RPS6B	Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein [Source:SGD;Acc:S000000385]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small-subunit processome	structural constituent of ribosome		
YBR182C	SMP1	Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors [Source:SGD;Acc:S000000386]	positive regulation of transcription from RNA polymerase II promoter, regulation of response to osmotic stress, regulation of transcription, DNA-dependent	cytoplasm, nucleus	DNA bending activity, DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YBR182C-A	YBR182C-A	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028603]	biological_process	cellular_component	molecular_function		
YBR183W	YPC1	Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance [Source:SGD;Acc:S000000387]	ceramide biosynthetic process, ceramide catabolic process, ceramide metabolic process	Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, phytoceramidase activity, sphingosine N-acyltransferase activity		
YBR184W	YBR184W	Putative protein of unknown function; YBR184W is not an essential gene [Source:SGD;Acc:S000000388]	biological_process	cellular_component	molecular_function		
YBR185C	MBA1	Membrane-associated mitochondrial ribosome receptor; involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane [Source:SGD;Acc:S000000389]	aerobic respiration, inner mitochondrial membrane organization, protein insertion into mitochondrial membrane from inner side	membrane, mitochondrial inner membrane, mitochondrion	ribosome binding		
YBR186W	PCH2	Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA [Source:SGD;Acc:S000000390]	meiosis, regulation of meiosis	chromosome, nucleolus, nucleus	ATP binding, molecular_function, nucleoside-triphosphatase activity, nucleotide binding		
YBR187W	GDT1	Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis [Source:SGD;Acc:S000000391]	biological_process	fungal-type vacuole, integral to membrane, membrane	molecular_function		
YBR188C	NTC20	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs [Source:SGD;Acc:S000000392]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	Prp19 complex, U2-type catalytic step 1 spliceosome, nucleus, spliceosomal complex	first spliceosomal transesterification activity		
YBR189W	RPS9B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins [Source:SGD;Acc:S000000393]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of translational fidelity, rRNA processing, ribosome biogenesis, translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome	RNA binding, rRNA binding, structural constituent of ribosome		
YBR190W	YBR190W	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W [Source:SGD;Acc:S000000394]					
YBR191W	RPL21A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein [Source:SGD;Acc:S000000395]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YBR191W-A	YBR191W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007594]					
YBR192W	RIM2	Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family [Source:SGD;Acc:S000000396]	mitochondrial genome maintenance, pyrimidine nucleotide transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, pyrimidine nucleotide transmembrane transporter activity, transporter activity		
YBR193C	MED8	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000000397]	transcription from RNA polymerase II promoter	mediator complex, nucleus	DNA binding		
YBR194W	AIM4	Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress [Source:SGD;Acc:S000000398]	biological_process	cytoplasm	molecular_function		
YBR195C	MSI1	Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46 [Source:SGD;Acc:S000000399]	DNA repair, DNA replication-dependent nucleosome assembly, Ras protein signal transduction, chromatin silencing	CAF-1 complex, chromatin silencing complex, cytoplasm, nucleus	protein binding		
YBR196C	PGI1	Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation [Source:SGD;Acc:S000000400]	gluconeogenesis, glycolysis, pentose-phosphate shunt	cytoplasm, cytosol, mitochondrion, plasma membrane enriched fraction	glucose-6-phosphate isomerase activity, isomerase activity		
YBR196C-A	YBR196C-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028534]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YBR196C-B	YBR196C-B	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028816]	biological_process	cellular_component	molecular_function		
YBR197C	YBR197C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene [Source:SGD;Acc:S000000401]	biological_process	cytoplasm, nucleus	molecular_function		
YBR198C	TAF5	Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification [Source:SGD;Acc:S000000402]	RNA polymerase II transcriptional preinitiation complex assembly, chromatin modification, histone acetylation	SAGA complex, SLIK (SAGA-like) complex, nucleus, transcription factor TFIID complex	chromatin binding, protein binding, ubiquitin binding		
YBR199W	KTR4	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000000403]	protein N-linked glycosylation, protein glycosylation	Golgi apparatus, integral to membrane, membrane	glycolipid 2-alpha-mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YBR200W	BEM1	Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p [Source:SGD;Acc:S000000404]	cell communication, cell morphogenesis involved in conjugation with cellular fusion, establishment of cell polarity	cellular bud neck, cellular bud tip, cytoplasm, cytoskeleton, incipient cellular bud site, mating projection tip	phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding, protein complex scaffold		
YBR200W-A	YBR200W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028535]	biological_process	cellular_component, extracellular region	molecular_function		
YBR201C-A	YBR201C-A	Putative protein of unknown function [Source:SGD;Acc:S000087085]	biological_process	cellular_component	molecular_function		
YBR201W	DER1	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p [Source:SGD;Acc:S000000405]	ER-associated protein catabolic process, protein transport, transport	Hrd1p ubiquitin ligase ERAD-L complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YBR202W	MCM7	Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase [Source:SGD;Acc:S000000406]	DNA replication, DNA strand elongation involved in DNA replication, DNA unwinding involved in replication, DNA-dependent DNA replication initiation, S phase of mitotic cell cycle, cell cycle, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, double-strand break repair via break-induced replication, pre-replicative complex assembly, regulation of transcription from RNA polymerase II promoter	DNA replication preinitiation complex, MCM complex, cytoplasm, nucleus, pre-replicative complex, replication fork protection complex	ATP binding, ATP-dependent 3'-5' DNA helicase activity, DNA binding, DNA replication origin binding, chromatin binding, four-way junction helicase activity, nucleoside-triphosphatase activity, nucleotide binding, single-stranded DNA binding, single-stranded DNA-dependent ATPase activity, transcription cofactor activity		
YBR203W	COS111	Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000407]	signal transduction	mitochondrion	molecular_function		
YBR204C	YBR204C	Serine hydrolase; YBR204C is not an essential gene [Source:SGD;Acc:S000000408]	biological_process, lipid catabolic process	cellular_component, peroxisome	hydrolase activity, serine hydrolase activity		
YBR205W	KTR3	Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000000409]	N-glycan processing, fungal-type cell wall organization, protein O-linked glycosylation, protein glycosylation	integral to membrane, membrane, membrane fraction	glycolipid 2-alpha-mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YBR206W	YBR206W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 [Source:SGD;Acc:S000000410]					
YBR207W	FTH1	Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis [Source:SGD;Acc:S000000411]	endocytosis, high-affinity iron ion transport, ion transport, iron ion transport, transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	iron ion transmembrane transporter activity		
YBR208C	DUR1,2	Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation [Source:SGD;Acc:S000000412]	allantoin catabolic process, arginine metabolic process, metabolic process, protein folding, regulation of transcription, DNA-dependent, urea catabolic process	cytoplasm	ATP binding, allophanate hydrolase activity, biotin binding, biotin carboxylase activity, carbon-nitrogen ligase activity, with glutamine as amido-N-donor, catalytic activity, hydrolase activity, ligase activity, nucleotide binding, peptidyl-prolyl cis-trans isomerase activity, sequence-specific DNA binding transcription factor activity, urea carboxylase activity		
YBR209W	YBR209W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene [Source:SGD;Acc:S000000413]					
YBR210W	ERV15	Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p [Source:SGD;Acc:S000000414]	ER to Golgi vesicle-mediated transport, axial cellular bud site selection, intracellular signal transduction	ER to Golgi transport vesicle, integral to membrane, membrane	molecular_function		
YBR211C	AME1	Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance [Source:SGD;Acc:S000000415]	attachment of spindle microtubules to kinetochore, cell cycle, cell division, meiosis, mitosis, protein localization to kinetochore	COMA complex, chromosome, centromeric region, condensed chromosome kinetochore, kinetochore, nucleus, spindle pole body	molecular_function		
YBR212W	NGR1	RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase [Source:SGD;Acc:S000000416]	3'-UTR-mediated mRNA destabilization, mitochondrion organization	cytoplasm, cytoplasmic mRNA processing body, perinuclear region of cytoplasm, stress granule	RNA binding, mRNA binding, nucleic acid binding, nucleotide binding		
YBR213W	MET8	Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis [Source:SGD;Acc:S000000417]	cellular amino acid biosynthetic process, metabolic process, methionine biosynthetic process, oxidation-reduction process, porphyrin biosynthetic process, siroheme biosynthetic process, sulfate assimilation	cellular_component	binding, catalytic activity, ferrochelatase activity, lyase activity, oxidoreductase activity, precorrin-2 dehydrogenase activity, sirohydrochlorin ferrochelatase activity		
YBR214W	SDS24	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; may play an indirect role in fluid-phase endocytosis [Source:SGD;Acc:S000000418]	cytokinetic cell separation, endocytosis	cytoplasm	molecular_function, protein binding		
YBR215W	HPC2	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes [Source:SGD;Acc:S000000419]	DNA replication-independent nucleosome assembly, chromatin modification, regulation of transcription involved in G1/S phase of mitotic cell cycle, transcription elongation from RNA polymerase II promoter	HIR complex, nucleus	DNA binding, nucleosome binding		
YBR216C	YBP1	Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress [Source:SGD;Acc:S000000420]	cellular response to oxidative stress	cytoplasm	molecular_function		
YBR217W	ATG12	Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation [Source:SGD;Acc:S000000421]	C-terminal protein lipidation, CVT pathway, autophagic vacuole assembly, autophagy, macroautophagy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein transport, transport	Atg12-Atg5-Atg16 complex, cytoplasm, membrane fraction	Atg8 ligase activity, protein tag		
YBR218C	PYC2	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis [Source:SGD;Acc:S000000422]	NADPH regeneration, gluconeogenesis, metabolic process	cytoplasm, cytosol	ATP binding, biotin binding, biotin carboxylase activity, catalytic activity, ligase activity, metal ion binding, nucleotide binding, pyruvate carboxylase activity		
YBR219C	YBR219C	Putative protein of unknown function; YBR219C is not an essential gene [Source:SGD;Acc:S000000423]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YBR220C	YBR220C	Putative protein of unknown function; YBR220C is not an essential gene [Source:SGD;Acc:S000000424]	biological_process, transport	cellular_component, integral to membrane, membrane	molecular_function		
YBR221C	PDB1	E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria [Source:SGD;Acc:S000000425]	acetyl-CoA biosynthetic process from pyruvate, glycolysis, metabolic process, oxidation-reduction process	mitochondrial matrix, mitochondrial nucleoid, mitochondrial pyruvate dehydrogenase complex, mitochondrion	catalytic activity, oxidoreductase activity, pyruvate dehydrogenase (acetyl-transferring) activity		
YBR221W-A	YBR221W-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028817]	biological_process	cellular_component	molecular_function		
YBR222C	PCS60	Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase [Source:SGD;Acc:S000000426]	biological_process, metabolic process	cytoplasm, membrane, peroxisomal matrix, peroxisomal membrane, peroxisome	AMP binding, catalytic activity, ligase activity, mRNA binding		
YBR223C	TDP1	Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI [Source:SGD;Acc:S000000427]	DNA repair, response to DNA damage stimulus	nucleus	3'-tyrosyl-DNA phosphodiesterase activity, 5'-tyrosyl-DNA phosphodiesterase activity, exonuclease activity, hydrolase activity, nuclease activity, phosphoric diester hydrolase activity		
YBR223W-A	YBR223W-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps YBR223C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028604]					
YBR224W	YBR224W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1 [Source:SGD;Acc:S000000428]					
YBR225W	YBR225W	Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components [Source:SGD;Acc:S000000429]	biological_process	cellular_component	molecular_function		
YBR226C	YBR226C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W [Source:SGD;Acc:S000000430]					
YBR227C	MCX1	Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins [Source:SGD;Acc:S000000431]	protein folding, protein refolding	mitochondrial matrix, mitochondrion	ATP binding, molecular_function, nucleoside-triphosphatase activity, nucleotide binding, unfolded protein binding		
YBR228W	SLX1	Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p [Source:SGD;Acc:S000000432]	DNA recombination, DNA repair, DNA-dependent DNA replication, response to DNA damage stimulus	Slx1-Slx4 complex, intracellular, nucleus	5'-flap endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity		
YBR229C	ROT2	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations [Source:SGD;Acc:S000000433]	carbohydrate metabolic process, fungal-type cell wall biogenesis, metabolic process	alpha-glucosidase II complex, endoplasmic reticulum, endoplasmic reticulum lumen, mitochondrion	alpha-glucosidase activity, carbohydrate binding, catalytic activity, glucan 1,3-alpha-glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds		
YBR230C	OM14	Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron [Source:SGD;Acc:S000000434]	biological_process	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YBR230W-A	YBR230W-A	Putative protein of unknown function [Source:SGD;Acc:S000029722]	biological_process	cellular_component	molecular_function		
YBR231C	SWC5	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A [Source:SGD;Acc:S000000435]	chromatin modification, chromatin remodeling, histone exchange	Swr1 complex, nucleus	molecular_function		
YBR232C	YBR232C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000436]					
YBR233W	PBP2	RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length [Source:SGD;Acc:S000000437]	biological_process	cytoplasm, nucleus, ribonucleoprotein complex	RNA binding, molecular_function		
YBR233W-A	DAD3	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000007595]	cell cycle, cell division, chromosome segregation, mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization	DASH complex, chromosome, centromeric region, condensed chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle	microtubule binding		
YBR234C	ARC40	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches [Source:SGD;Acc:S000000438]	actin filament organization, actin nucleation, mitochondrion inheritance, regulation of actin filament polymerization	Arp2/3 protein complex, actin cortical patch, cytoplasm, cytoskeleton	actin binding, protein binding, ubiquitin binding		
YBR235W	YBR235W	Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene [Source:SGD;Acc:S000000439]	transmembrane transport, transport	cellular_component, integral to membrane, membrane	ion transmembrane transporter activity		
YBR236C	ABD1	Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA [Source:SGD;Acc:S000000440]	mRNA capping, mRNA processing	DNA-directed RNA polymerase II, holoenzyme, nucleus	RNA binding, mRNA (guanine-N7-)-methyltransferase activity, methyltransferase activity, transferase activity		
YBR237W	PRP5	RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA [Source:SGD;Acc:S000000441]	RNA splicing, mRNA processing, nuclear mRNA branch site recognition	nucleus, spliceosomal complex	ATP binding, ATP-dependent helicase activity, RNA-dependent ATPase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YBR238C	YBR238C	Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span [Source:SGD;Acc:S000000442]	aerobic respiration	cytoplasm, integral to mitochondrial membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YBR239C	ERT1	Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition [Source:SGD;Acc:S000000443]	biological_process, regulation of transcription, DNA-dependent, signal transduction	cytoplasm, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, signal transducer activity, zinc ion binding		
YBR240C	THI2	Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes [Source:SGD;Acc:S000000444]	positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, thiamine biosynthetic process	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YBR241C	YBR241C	Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene [Source:SGD;Acc:S000000445]	transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	substrate-specific transmembrane transporter activity, transporter activity		
YBR242W	YBR242W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene [Source:SGD;Acc:S000000446]	biological_process	cytoplasm, nucleus	catalytic activity, molecular_function		
YBR243C	ALG7	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin [Source:SGD;Acc:S000000447]	aerobic respiration, protein N-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YBR244W	GPX2	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress [Source:SGD;Acc:S000000448]	cellular response to oxidative stress, oxidation-reduction process, response to oxidative stress	cytoplasm, nucleus	glutathione peroxidase activity, oxidoreductase activity, peroxidase activity, phospholipid-hydroperoxide glutathione peroxidase activity		
YBR245C	ISW1	Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation [Source:SGD;Acc:S000000449]	ATP-dependent chromatin remodeling, chromatin modification, chromatin remodeling, nucleosome positioning, positive regulation of transcription from RNA polymerase II promoter, transcription elongation, DNA-dependent	ISW1 complex, chromatin remodeling complex, nucleus	ATP binding, ATPase activity, DNA binding, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, nucleic acid binding, nucleosome binding, nucleotide binding, protein binding		
YBR246W	RRT2	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotype [Source:SGD;Acc:S000000450]	biological_process	cellular_component	molecular_function, protein binding		
YBR247C	ENP1	Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus [Source:SGD;Acc:S000000451]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, cytoplasm, nucleolus, nucleus, preribosome, small subunit precursor	snoRNA binding		
YBR248C	HIS7	Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor [Source:SGD;Acc:S000000452]	cellular amino acid biosynthetic process, glutamine metabolic process, histidine biosynthetic process, metabolic process, purine nucleoside monophosphate biosynthetic process, response to stress	cytoplasm, intracellular	catalytic activity, imidazoleglycerol-phosphate synthase activity, lyase activity, oxo-acid-lyase activity, transferase activity, transferase activity, transferring pentosyl groups		
YBR249C	ARO4	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan [Source:SGD;Acc:S000000453]	aromatic amino acid family biosynthetic process, biosynthetic process, cellular amino acid biosynthetic process, metabolic process, response to stress	cytoplasm, nucleus	3-deoxy-7-phosphoheptulonate synthase activity, catalytic activity, transferase activity		
YBR250W	SPO23	Protein of unknown function; associates with meiosis-specific protein Spo1p [Source:SGD;Acc:S000000454]	meiosis, sporulation resulting in formation of a cellular spore	cellular_component	molecular_function		
YBR251W	MRPS5	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000000455]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YBR252W	DUT1	dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability [Source:SGD;Acc:S000000456]	dUTP metabolic process, nucleotide metabolic process, pyrimidine deoxyribonucleoside triphosphate catabolic process	cytoplasm, nucleus	dUTP diphosphatase activity, hydrolase activity, metal ion binding		
YBR253W	SRB6	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000000457]	regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus	structural molecule activity		
YBR254C	TRS20	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder [Source:SGD;Acc:S000000458]	ER to Golgi vesicle-mediated transport, transport, vesicle-mediated transport	Golgi apparatus, TRAPP complex, endoplasmic reticulum, intracellular	molecular_function		
YBR255C-A	YBR255C-A	Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000007649]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YBR255W	MTC4	Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 [Source:SGD;Acc:S000000459]	biological_process	cytoplasm, integral to membrane, membrane	molecular_function		
YBR256C	RIB5	Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway [Source:SGD;Acc:S000000460]	riboflavin biosynthetic process	soluble fraction	riboflavin synthase activity, transferase activity		
YBR257W	POP4	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P [Source:SGD;Acc:S000000461]	intronic box C/D snoRNA processing, mRNA cleavage, rRNA processing, tRNA processing	nucleolar ribonuclease P complex, nucleus, ribonuclease MRP complex, ribonuclease P complex	RNA binding, ribonuclease MRP activity, ribonuclease P activity, ribonuclease activity		
YBR258C	SHG1	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres [Source:SGD;Acc:S000000462]	histone H3-K4 methylation	Set1C/COMPASS complex, nucleus	histone methyltransferase activity (H3-K4 specific)		
YBR259W	YBR259W	Putative protein of unknown function; YBR259W is not an essential gene [Source:SGD;Acc:S000000463]	biological_process	cellular_component	molecular_function		
YBR260C	RGD1	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization [Source:SGD;Acc:S000000464]	osmosensory signaling pathway, response to acid, signal transduction	actin cortical patch, cellular bud, cytoplasm, intracellular, mating projection tip	GTPase activator activity, Rho GTPase activator activity, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding		
YBR261C	TAE1	AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000000465]	N-terminal peptidyl-proline dimethylation, translation	cytoplasm, cytosol	N-terminal protein N-methyltransferase activity, methyltransferase activity, transferase activity		
YBR262C	AIM5	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000000466]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YBR263W	SHM1	Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine [Source:SGD;Acc:S000000467]	L-serine metabolic process, glycine metabolic process, one-carbon metabolic process, serine family amino acid biosynthetic process	mitochondrion	catalytic activity, glycine hydroxymethyltransferase activity, pyridoxal phosphate binding, transferase activity		
YBR264C	YPT10	Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles [Source:SGD;Acc:S000000468]	Golgi organization, protein transport, small GTPase mediated signal transduction, transport	cytoplasm, membrane, plasma membrane	GTP binding, GTPase activity, guanyl nucleotide binding, nucleotide binding		
YBR265W	TSC10	3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family [Source:SGD;Acc:S000000469]	3-keto-sphinganine metabolic process, metabolic process, oxidation-reduction process, sphingolipid biosynthetic process	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrial outer membrane	3-dehydrosphinganine reductase activity, binding, catalytic activity, oxidoreductase activity, oxidoreductase activity, acting on NADH or NADPH		
YBR266C	SLM6	Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase [Source:SGD;Acc:S000000470]					
YBR267W	REI1	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network [Source:SGD;Acc:S000000471]	budding cell bud growth, mitotic cell cycle, nucleocytoplasmic transport, ribosomal large subunit biogenesis, ribosome biogenesis	cytoplasm, cytosolic large ribosomal subunit, intracellular, preribosome, large subunit precursor	metal ion binding, sequence-specific DNA binding, zinc ion binding		
YBR268W	MRPL37	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000000472]	mitochondrial translation, sporulation resulting in formation of a cellular spore	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YBR269C	FMP21	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000473]	biological_process	mitochondrion	molecular_function		
YBR270C	BIT2	Subunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; similar to Bit61p [Source:SGD;Acc:S000000474]	biological_process	cellular_component	molecular_function		
YBR271W	YBR271W	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000000475]	biological_process	cytoplasm	S-adenosylmethionine-dependent methyltransferase activity		
YBR272C	HSM3	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b [Source:SGD;Acc:S000000476]	DNA repair, mismatch repair, proteasome regulatory particle assembly, response to DNA damage stimulus	cytoplasm, cytosol, nucleus, proteasome regulatory particle, base subcomplex	binding, molecular_function		
YBR273C	UBX7	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p [Source:SGD;Acc:S000000477]	sporulation resulting in formation of a cellular spore, ubiquitin-dependent protein catabolic process	endoplasmic reticulum, nuclear envelope	molecular_function, protein binding		
YBR274W	CHK1	Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase [Source:SGD;Acc:S000000478]	DNA damage checkpoint, cell cycle, protein phosphorylation, replication fork protection, response to DNA damage stimulus	nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YBR275C	RIF1	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation [Source:SGD;Acc:S000000479]	cell cycle, chromatin silencing at silent mating-type cassette, telomere capping, telomere maintenance	chromosome, telomeric region, nuclear telomere cap complex, nucleus	telomeric DNA binding		
YBR276C	PPS1	Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle [Source:SGD;Acc:S000000480]	cell cycle, dephosphorylation, inactivation of MAPK activity, protein dephosphorylation, regulation of S phase of mitotic cell cycle	cellular_component	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity		
YBR277C	YBR277C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W [Source:SGD;Acc:S000000481]					
YBR278W	DPB3	Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle [Source:SGD;Acc:S000000482]	DNA replication, chromatin silencing at telomere, lagging strand elongation, leading strand elongation, mismatch repair, nucleotide-excision repair	epsilon DNA polymerase complex, nucleus, replication fork	DNA binding, DNA-directed DNA polymerase activity, double-stranded DNA binding, nucleotidyltransferase activity, transferase activity		
YBR279W	PAF1	Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; homolog of human PD2/hPAF1 [Source:SGD;Acc:S000000483]	DNA recombination, histone methylation, transcription elongation from RNA polymerase I promoter, transcription elongation from RNA polymerase II promoter	Cdc73/Paf1 complex, nucleoplasm, nucleus, transcription elongation factor complex			
YBR280C	SAF1	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 [Source:SGD;Acc:S000000484]	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	ubiquitin-protein ligase activity		
YBR281C	DUG2	Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) [Source:SGD;Acc:S000000485]	glutathione catabolic process, metabolic process	cytoplasm, nucleus	dipeptidase activity, hydrolase activity, metal ion binding, metallopeptidase activity, omega peptidase activity, peptidase activity, protein binding		
YBR282W	MRPL27	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000000486]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YBR283C	SSH1	Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential [Source:SGD;Acc:S000000487]	SRP-dependent cotranslational protein targeting to membrane, protein transport, transmembrane transport, transport	Ssh1 translocon complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity, protein transmembrane transporter activity, signal sequence binding		
YBR284W	YBR284W	Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin and synthetic phenotype with alpha-synuclein [Source:SGD;Acc:S000000488]	biological_process, purine base metabolic process, purine ribonucleoside monophosphate biosynthetic process	cellular_component, integral to membrane, membrane	deaminase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, molecular_function		
YBR285W	YBR285W	Putative protein of unknown function; YBR285W is not an essential gene [Source:SGD;Acc:S000000489]	biological_process	cellular_component	molecular_function		
YBR286W	APE3	Vacuolar aminopeptidase Y, processed to mature form by Prb1p [Source:SGD;Acc:S000000490]	proteolysis, vacuolar protein catabolic process	fungal-type vacuole, vacuole	aminopeptidase activity, hydrolase activity, metallopeptidase activity, peptidase activity		
YBR287W	YBR287W	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene [Source:SGD;Acc:S000000491]	biological_process, transmembrane transport, transport	endoplasmic reticulum, integral to membrane, membrane	molecular_function		
YBR288C	APM3	Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway [Source:SGD;Acc:S000000492]	Golgi to vacuole transport, intracellular protein transport, protein transport, transport, vesicle-mediated transport	AP-3 adaptor complex, Golgi apparatus, clathrin adaptor complex, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane	molecular_function, protein binding		
YBR289W	SNF5	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p [Source:SGD;Acc:S000000493]	ATP-dependent chromatin remodeling, chromatin remodeling, double-strand break repair, nucleosome mobilization, positive regulation of transcription, DNA-dependent	SWI/SNF complex, nuclear chromosome, nucleus			
YBR290W	BSD2	Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification [Source:SGD;Acc:S000000494]	metal ion transport, protein targeting to vacuole, response to stress, transport, ubiquitin-dependent protein catabolic process	endoplasmic reticulum, fungal-type vacuole membrane, integral to membrane, membrane, vacuole	protein binding		
YBR291C	CTP1	Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family [Source:SGD;Acc:S000000495]	mitochondrial citrate transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, tricarboxylate secondary active transmembrane transporter activity		
YBR292C	YBR292C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene [Source:SGD;Acc:S000000496]					
YBR293W	VBA2	Permease of basic amino acids in the vacuolar membrane [Source:SGD;Acc:S000000497]	amino acid transport, basic amino acid transport, transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	basic amino acid transmembrane transporter activity, drug transmembrane transporter activity		
YBR294W	SUL1	High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates [Source:SGD;Acc:S000000498]	sulfate transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	secondary active sulfate transmembrane transporter activity, sulfate transmembrane transporter activity, transporter activity		
YBR295W	PCA1	Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function [Source:SGD;Acc:S000000499]	ATP biosynthetic process, cadmium ion transport, cellular iron ion homeostasis, cellular metal ion homeostasis, copper ion transport, ion transport, metabolic process, metal ion transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, cadmium-exporting ATPase activity, catalytic activity, copper ion binding, copper-exporting ATPase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, metal ion binding, metal ion transmembrane transporter activity, nucleotide binding		
YBR296C	PHO89	Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p [Source:SGD;Acc:S000000500]	phosphate transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	inorganic phosphate transmembrane transporter activity, sodium:inorganic phosphate symporter activity, symporter activity		
YBR296C-A	YBR296C-A	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028605]	biological_process	cellular_component	molecular_function		
YBR297W	MAL33	MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C [Source:SGD;Acc:S000000501]	cellular carbohydrate metabolic process, maltose metabolic process, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YBR298C	MAL31	Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C [Source:SGD;Acc:S000000502]	alpha-glucoside transport, carbohydrate transport, maltose metabolic process, transmembrane transport, transport	integral to membrane, membrane, membrane fraction	alpha-glucoside:hydrogen symporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YBR298C-A	YBR298C-A	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028606]	biological_process	cellular_component	molecular_function		
YBR299W	MAL32	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose [Source:SGD;Acc:S000000503]	carbohydrate metabolic process, maltose catabolic process, maltose metabolic process, metabolic process, sucrose catabolic process	plasma membrane enriched fraction	alpha-glucosidase activity, catalytic activity, cation binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, maltose alpha-glucosidase activity, sucrose alpha-glucosidase activity		
YBR300C	YBR300C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene [Source:SGD;Acc:S000000504]					
YBR301W	PAU24	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth [Source:SGD;Acc:S000000505]	biological_process, cellular cell wall organization, response to stress	cell wall, extracellular region, fungal-type cell wall	molecular_function		
YBR302C	COS2	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000000506]	biological_process	fungal-type vacuole, integral to membrane, membrane	molecular_function		
YCL001W	RER1	Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER [Source:SGD;Acc:S000000507]	ER to Golgi vesicle-mediated transport, protein retention in ER lumen, retrograde vesicle-mediated transport, Golgi to ER	COPI-coated vesicle, ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, integral to membrane, membrane	molecular_function		
YCL001W-A	YCL001W-A	Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III [Source:SGD;Acc:S000007221]	biological_process, translation	cellular_component	molecular_function		
YCL001W-B	YCL001W-B	Putative protein of unknown function; YCL001W-B gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III [Source:SGD;Acc:S000007596]	biological_process, translation	cellular_component	molecular_function		
YCL002C	YCL002C	Putative protein of unknown function; YCL002C is not an essential gene [Source:SGD;Acc:S000000508]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YCL004W	PGS1	Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis [Source:SGD;Acc:S000000510]	metabolic process, phospholipid biosynthetic process	mitochondrion	ATP binding, CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity, catalytic activity, nucleotide binding, phosphotransferase activity, for other substituted phosphate groups, transferase activity		
YCL005W	LDB16	Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria [Source:SGD;Acc:S000000511]	biological_process	integral to membrane, lipid particle, membrane, mitochondrion	molecular_function		
YCL005W-A	VMA9	Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis [Source:SGD;Acc:S000028508]	ATP hydrolysis coupled proton transport, cell wall mannoprotein biosynthetic process, ion transport, protein complex assembly, proton transport, transmembrane transport, transport, vacuolar acidification	integral to membrane, membrane, proton-transporting V-type ATPase, V0 domain, vacuolar membrane, vacuolar proton-transporting V-type ATPase, V0 domain, vacuole	ATPase activity, coupled to transmembrane movement of ions, hydrogen ion transmembrane transporter activity		
YCL007C	YCL007C	Dubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A [Source:SGD;Acc:S000000513]					
YCL008C	STP22	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype [Source:SGD;Acc:S000000514]	late endosome to vacuole transport, post-translational protein modification, protein modification process, protein targeting to membrane, protein targeting to vacuole, protein transport, regulation of protein metabolic process, transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ESCRT I complex, cytoplasm, endosome, internal side of plasma membrane, late endosome membrane, membrane	acid-amino acid ligase activity, small conjugating protein ligase activity, ubiquitin binding		
YCL009C	ILV6	Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria [Source:SGD;Acc:S000000515]	branched chain family amino acid biosynthetic process, cellular amino acid biosynthetic process, metabolic process	acetolactate synthase complex, mitochondrial nucleoid, mitochondrion	acetolactate synthase activity, amino acid binding, enzyme regulator activity		
YCL010C	SGF29	Probable subunit of SAGA histone acetyltransferase complex [Source:SGD;Acc:S000000516]	chromatin modification, histone acetylation	SAGA complex, nucleus	molecular_function		
YCL011C	GBP2	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro [Source:SGD;Acc:S000000517]	poly(A)+ mRNA export from nucleus, telomere maintenance	chromosome, telomeric region, nucleus, stress granule	DNA binding, RNA binding, nucleic acid binding, nucleotide binding, telomeric DNA binding		
YCL012C	YCL012C	Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene [Source:SGD;Acc:S000029705]	biological_process	cellular_component	molecular_function		
YCL014W	BUD3	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding [Source:SGD;Acc:S000000520]	axial cellular bud site selection, cell cycle, cellular bud site selection, cytokinesis, regulation of Rho protein signal transduction	cellular bud neck, cellular bud neck contractile ring, intracellular	Rho guanyl-nucleotide exchange factor activity, molecular_function		
YCL016C	DCC1	Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance [Source:SGD;Acc:S000000521]	DNA replication, mitotic sister chromatid cohesion, response to DNA damage stimulus	Ctf18 RFC-like complex	molecular_function		
YCL017C	NFS1	Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria [Source:SGD;Acc:S000000522]	cellular iron ion homeostasis, cysteine metabolic process, iron-sulfur cluster assembly, metabolic process, mitochondrial tRNA thio-modification, tRNA processing, tRNA thio-modification, tRNA wobble uridine modification	mitochondrion, nucleus	catalytic activity, cysteine desulfurase activity, pyridoxal phosphate binding, transferase activity		
YCL018W	LEU2	Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway [Source:SGD;Acc:S000000523]	branched chain family amino acid biosynthetic process, cellular amino acid biosynthetic process, leucine biosynthetic process, oxidation-reduction process	cytoplasm, soluble fraction	3-isopropylmalate dehydrogenase activity, NAD binding, magnesium ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YCL019W	YCL019W	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000000524]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YCL020W	YCL020W	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000000525]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YCL021W-A	YCL021W-A	Putative protein of unknown function [Source:SGD;Acc:S000007549]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YCL022C	YCL022C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W [Source:SGD;Acc:S000000527]					
YCL023C	YCL023C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4 [Source:SGD;Acc:S000000528]					
YCL024W	KCC4	Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p [Source:SGD;Acc:S000000529]	budding cell bud growth, cell cycle, cell division, protein phosphorylation, regulation of cell shape, septin checkpoint, septin ring assembly	cellular bud neck, cellular bud neck septin collar, incipient cellular bud site, septin ring	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YCL025C	AGP1	Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) [Source:SGD;Acc:S000000530]	amino acid transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	L-proline transmembrane transporter activity, amino acid transmembrane transporter activity		
YCL026C-A	FRM2	Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; expression induced in cells treated with the mycotoxin patulin; has similarity to bacterial nitroreductases [Source:SGD;Acc:S000000589]	fatty acid metabolic process, lipid metabolic process, negative regulation of fatty acid metabolic process	cytoplasm, nucleus	NAD(P)H nitroreductase activity, oxidoreductase activity		
YCL026C-B	HBN1	Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion [Source:SGD;Acc:S000007548]	biological_process, oxidation-reduction process	cytoplasm, nucleus	NAD(P)H nitroreductase activity, oxidoreductase activity		
YCL027W	FUS1	Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate [Source:SGD;Acc:S000000532]	cortical protein anchoring, cytogamy, regulation of termination of mating projection growth	integral to membrane, integral to plasma membrane, mating projection tip, membrane	molecular_function, protein binding		
YCL028W	RNQ1	[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate [Source:SGD;Acc:S000000533]	biological_process	cytoplasm, cytosol, nucleus	binding, molecular_function		
YCL029C	BIK1	Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 [Source:SGD;Acc:S000000534]	cell cycle, cell division, karyogamy involved in conjugation with cellular fusion, mitosis, mitotic anaphase B, mitotic spindle elongation, mitotic spindle organization in nucleus, negative regulation of microtubule polymerization, nuclear migration involved in conjugation with cellular fusion	cell cortex, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, mating projection tip, microtubule, microtubule plus end, nucleus, spindle, spindle microtubule, spindle pole body	microtubule binding, protein homodimerization activity		
YCL030C	HIS4	Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis [Source:SGD;Acc:S000000535]	cellular amino acid biosynthetic process, histidine biosynthetic process, metabolic process, oxidation-reduction process	intracellular	ATP binding, NAD binding, catalytic activity, histidinol dehydrogenase activity, hydrolase activity, metal ion binding, nucleotide binding, oxidoreductase activity, phosphoribosyl-AMP cyclohydrolase activity, phosphoribosyl-ATP diphosphatase activity, zinc ion binding		
YCL031C	RRP7	Essential protein involved in rRNA processing and ribosome biogenesis [Source:SGD;Acc:S000000536]	rRNA processing, ribosomal small subunit assembly, ribosome biogenesis	CURI complex, UTP-C complex, nucleolus, nucleus	molecular_function		
YCL032W	STE50	Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction [Source:SGD;Acc:S000000537]	MAPKKK cascade involved in osmosensory signaling pathway, cell cycle, cell cycle arrest, pheromone-dependent signal transduction involved in conjugation with cellular fusion, response to pheromone, signal transduction, signal transduction involved in filamentous growth	cytoplasm	SAM domain binding, protein binding, protein kinase regulator activity		
YCL033C	MXR2	Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan [Source:SGD;Acc:S000000538]	cellular response to oxidative stress, oxidation-reduction process	mitochondrion	metal ion binding, peptide-methionine (R)-S-oxide reductase activity, peptide-methionine-(S)-S-oxide reductase activity		
YCL034W	LSB5	Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat [Source:SGD;Acc:S000000539]	actin cortical patch localization, actin cytoskeleton organization, actin filament organization, endocytosis, intracellular protein transport	actin cortical patch, cell cortex, cytoplasm, cytoskeleton, intracellular	molecular_function		
YCL035C	GRX1	Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage [Source:SGD;Acc:S000000540]	cell redox homeostasis, cellular response to oxidative stress, electron transport chain, protein glutathionylation, transport	cytoplasm, nucleus	disulfide oxidoreductase activity, electron carrier activity, glutathione peroxidase activity, glutathione transferase activity, protein disulfide oxidoreductase activity		
YCL036W	GFD2	Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation [Source:SGD;Acc:S000000541]	biological_process	cellular_component	molecular_function, nucleic acid binding		
YCL037C	SRO9	Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif [Source:SGD;Acc:S000000542]	translation	cytoplasm, polysome	RNA binding		
YCL038C	ATG22	Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation [Source:SGD;Acc:S000000543]	amino acid export from vacuole, autophagy, protein transport, transport	integral to fungal-type vacuolar membrane, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YCL039W	GID7	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions [Source:SGD;Acc:S000000544]	negative regulation of gluconeogenesis, proteasomal ubiquitin-dependent protein catabolic process	GID complex, cytoplasm, nucleus	molecular_function, protein binding		
YCL040W	GLK1	Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources [Source:SGD;Acc:S000000545]	carbohydrate metabolic process, glucose import, glucose metabolic process, glycolysis, mannose metabolic process	cytosol, plasma membrane enriched fraction	ATP binding, glucokinase activity, hexokinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YCL041C	YCL041C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W [Source:SGD;Acc:S000000546]					
YCL042W	YCL042W	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm [Source:SGD;Acc:S000000547]	biological_process	cytoplasm	molecular_function		
YCL043C	PDI1	Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds [Source:SGD;Acc:S000000548]	cell redox homeostasis, protein folding	endoplasmic reticulum, endoplasmic reticulum lumen	isomerase activity, protein disulfide isomerase activity, protein disulfide oxidoreductase activity		
YCL044C	MGR1	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA [Source:SGD;Acc:S000000549]	misfolded or incompletely synthesized protein catabolic process	i-AAA complex, integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	misfolded protein binding		
YCL045C	EMC1	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p [Source:SGD;Acc:S000000550]	protein folding in endoplasmic reticulum	ER membrane protein complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YCL046W	YCL046W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C [Source:SGD;Acc:S000000551]					
YCL047C	YCL047C	Putative protein of unknown function [Source:SGD;Acc:S000000552]	biological_process	cellular_component	molecular_function		
YCL048W	SPS22	Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall [Source:SGD;Acc:S000000553]	ascospore wall assembly, fungal-type cell wall organization, sporulation resulting in formation of a cellular spore	anchored to membrane, membrane, plasma membrane	molecular_function		
YCL048W-A	YCL048W-A	Putative protein of unknown function [Source:SGD;Acc:S000087203]	biological_process	anchored to membrane, cellular_component, membrane, plasma membrane	molecular_function		
YCL049C	YCL049C	Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene [Source:SGD;Acc:S000000554]	biological_process	membrane fraction	molecular_function		
YCL050C	APA1	Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p [Source:SGD;Acc:S000000555]	nucleotide metabolic process	cytoplasm, nucleus	ATP adenylyltransferase activity, ATP binding, bis(5'-nucleosyl)-tetraphosphatase activity, catalytic activity, hydrolase activity, nucleotide binding, nucleotidyltransferase activity, sulfate adenylyltransferase (ADP) activity, transferase activity		
YCL051W	LRE1	Protein involved in control of cell wall structure and stress response; inhibits Cbk1p protein kinase activity; overproduction confers resistance to cell-wall degrading enzymes [Source:SGD;Acc:S000000556]	fungal-type cell wall organization, response to heat	fungal-type cell wall	protein kinase inhibitor activity		
YCL052C	PBN1	Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X [Source:SGD;Acc:S000000557]	ER-associated protein catabolic process, GPI anchor biosynthetic process, protein processing	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	mannosyltransferase activity		
YCL054W	SPB1	AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants [Source:SGD;Acc:S000000559]	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), methylation, rRNA methylation, rRNA processing, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor	methyltransferase activity, nucleic acid binding, rRNA (guanine) methyltransferase activity, rRNA (uridine-2'-O-)-methyltransferase activity, transferase activity		
YCL055W	KAR4	Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone [Source:SGD;Acc:S000000560]	G1 phase of mitotic cell cycle, karyogamy, karyogamy involved in conjugation with cellular fusion, meiosis, negative regulation of transcription from RNA polymerase II promoter by pheromones, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription from RNA polymerase II promoter by pheromones	cytoplasm, nucleus	methyltransferase activity, sequence-specific DNA binding transcription factor activity		
YCL056C	YCL056C	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant displays decreased thermotolerance [Source:SGD;Acc:S000000561]	biological_process	cytoplasm	molecular_function		
YCL057C-A	YCL057C-A	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000007547]	biological_process	integral to membrane, membrane, mitochondrion	molecular_function		
YCL057W	PRD1	Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins [Source:SGD;Acc:S000000562]	proteolysis	cytoplasm, mitochondrial intermembrane space, mitochondrion	hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity		
YCL058C	FYV5	Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis [Source:SGD;Acc:S000000563]	cellular ion homeostasis, pheromone-dependent signal transduction involved in conjugation with cellular fusion	cellular_component	molecular_function		
YCL058W-A	ADF1	Transcriptional repressor encoded by the antisense strand of the FYV5 gene; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand [Source:SGD;Acc:S000028518]	negative regulation of transcription from RNA polymerase II promoter, pheromone-dependent signal transduction involved in conjugation with cellular fusion	nucleus			
YCL059C	KRR1	Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit [Source:SGD;Acc:S000000564]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis	90S preribosome, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	RNA binding, molecular_function		
YCL061C	MRC1	S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres [Source:SGD;Acc:S000000566]	DNA repair, DNA replication, DNA replication checkpoint, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, intra-S DNA damage checkpoint, maintenance of DNA repeat elements, mitotic sister chromatid cohesion, replication fork protection, telomere maintenance	nuclear chromosome, nuclear replication fork, nucleus, replication fork protection complex	molecular_function		
YCL063W	VAC17	Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p [Source:SGD;Acc:S000000568]	vacuole inheritance	membrane, vacuolar membrane, vacuole	protein anchor		
YCL064C	CHA1	Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine [Source:SGD;Acc:S000000569]	L-serine catabolic process, cellular amino acid metabolic process, metabolic process, threonine catabolic process	mitochondrial nucleoid, mitochondrion	L-serine ammonia-lyase activity, L-threonine ammonia-lyase activity, catalytic activity, lyase activity, pyridoxal phosphate binding		
YCL065W	YCL065W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps HMLALPHA1 [Source:SGD;Acc:S000000570]					
YCL066W	HMLALPHA1	Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression [Source:SGD;Acc:S000000571]	positive regulation of transcription, mating-type specific, regulation of transcription from RNA polymerase II promoter, regulation of transcription, mating-type specific, single fertilization	nucleus	DNA binding, mating pheromone activity, sequence-specific DNA binding, transcription coactivator activity		
YCL067C	HMLALPHA2	Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression [Source:SGD;Acc:S000000572]	donor selection, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, regulation of transcription, mating-type specific	nucleus	DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, transcription corepressor activity		
YCL068C	YCL068C	Putative protein of unknown function [Source:SGD;Acc:S000000573]	biological_process, small GTPase mediated signal transduction	cellular_component, intracellular	guanyl-nucleotide exchange factor activity, molecular_function		
YCL069W	VBA3	Permease of basic amino acids in the vacuolar membrane [Source:SGD;Acc:S000000574]	amino acid transport, basic amino acid transport, transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	basic amino acid transmembrane transporter activity, transporter activity		
YCL073C	YCL073C	Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W [Source:SGD;Acc:S000000575]	transmembrane transport, transport	integral to membrane, membrane	transporter activity		
YCL076W	YCL076W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000581]					
YCR001W	YCR001W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene [Source:SGD;Acc:S000000594]					
YCR002C	CDC10	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM [Source:SGD;Acc:S000000595]	ascospore wall assembly, axial cellular bud site selection, bipolar cellular bud site selection, cell cycle, cell division, cell morphogenesis, cell morphogenesis involved in conjugation with cellular fusion, conjugation with cellular fusion, cytokinesis, establishment of cell polarity, fungal-type cell wall organization	cellular bud neck, cellular bud neck septin ring, mating projection base, mating projection tip, membrane, septin complex	1-phosphatidylinositol binding, GTP binding, GTPase activity, nucleotide binding, structural constituent of cytoskeleton		
YCR003W	MRPL32	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000000596]	mitochondrial translation, translation	large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YCR004C	YCP4	Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000597]	biological_process	cytoplasm, membrane, membrane raft, mitochondrion, plasma membrane enriched fraction	FMN binding, electron carrier activity, oxidoreductase activity		
YCR005C	CIT2	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors [Source:SGD;Acc:S000000598]	cellular carbohydrate metabolic process, citrate metabolic process, glutamate biosynthetic process, glyoxylate cycle, tricarboxylic acid cycle	mitochondrion, peroxisome	citrate (Si)-synthase activity, transferase activity, transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer		
YCR006C	YCR006C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000599]					
YCR007C	YCR007C	Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene [Source:SGD;Acc:S000000600]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YCR008W	SAT4	Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p [Source:SGD;Acc:S000000601]	G1/S transition of mitotic cell cycle, cellular cation homeostasis, cellular protein localization, protein dephosphorylation, protein phosphorylation	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YCR009C	RVS161	Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress [Source:SGD;Acc:S000000602]	actin cortical patch localization, actin cytoskeleton organization, actin cytoskeleton reorganization, conjugation with cellular fusion, endocytosis, lipid tube assembly, response to osmotic stress, response to starvation	actin cortical patch, cytoplasm, cytoskeleton, mating projection, mating projection tip, membrane raft	cytoskeletal protein binding, lipid binding, protein binding		
YCR010C	ADY2	Acetate transporter required for normal sporulation; phosphorylated in mitochondria [Source:SGD;Acc:S000000603]	acetate transport, ammonium transport, ion transport, meiosis, nitrogen utilization, transmembrane transport, transport	integral to membrane, membrane, mitochondrion, plasma membrane, plasma membrane enriched fraction, vacuolar membrane, vacuole	acetate transmembrane transporter activity, ammonium transmembrane transporter activity		
YCR011C	ADP1	Putative ATP-dependent permease of the ABC transporter family of proteins [Source:SGD;Acc:S000000604]	transmembrane transport, transport	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YCR012W	PGK1	3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis [Source:SGD;Acc:S000000605]	gluconeogenesis, glycolysis	cytoplasm, mitochondrion, plasma membrane enriched fraction	ATP binding, kinase activity, nucleotide binding, phosphoglycerate kinase activity, transferase activity		
YCR013C	YCR013C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant [Source:SGD;Acc:S000000606]					
YCR014C	POL4	DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta [Source:SGD;Acc:S000000607]	DNA repair, DNA replication, base-excision repair, gap-filling, double-strand break repair, double-strand break repair via nonhomologous end joining, response to DNA damage stimulus	nucleus	DNA binding, DNA-directed DNA polymerase activity, catalytic activity, metal ion binding, nucleotidyltransferase activity, transferase activity		
YCR015C	YCR015C	Putative protein of unknown function; YCR015C is not an essential gene [Source:SGD;Acc:S000000608]	biological_process	cellular_component	molecular_function		
YCR016W	YCR016W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000000609]	biological_process	nucleolus, nucleus	molecular_function		
YCR017C	CWH43	Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion [Source:SGD;Acc:S000000610]	GPI anchor biosynthetic process, fungal-type cell wall organization	cellular bud neck, cellular bud tip, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, integral to plasma membrane, membrane, plasma membrane	molecular_function		
YCR018C	SRD1	Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation [Source:SGD;Acc:S000000611]	rRNA processing, regulation of transcription, DNA-dependent	cytoplasm, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YCR018C-A	YCR018C-A	Putative protein of unknown function; encoded opposite a Ty1 LTR [Source:SGD;Acc:S000007230]					
YCR019W	MAK32	Protein necessary for structural stability of L-A double-stranded RNA-containing particles [Source:SGD;Acc:S000000612]	interspecies interaction between organisms	cellular_component	molecular_function		
YCR020C	PET18	Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin [Source:SGD;Acc:S000000613]	thiamine metabolic process	cytosol	molecular_function		
YCR020C-A	MAK31	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family [Source:SGD;Acc:S000000614]	N-terminal protein amino acid acetylation	NatC complex	peptide alpha-N-acetyltransferase activity		
YCR020W-B	HTL1	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance [Source:SGD;Acc:S000006439]	cell cycle, chromatin remodeling, nucleosome disassembly, regulation of cell cycle, response to DNA damage stimulus, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	chromatin binding		
YCR021C	HSP30	Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase [Source:SGD;Acc:S000000615]	ion transport, negative regulation of ATPase activity, response to stress	integral to membrane, membrane, plasma membrane, plasma membrane enriched fraction	ion channel activity, molecular_function		
YCR022C	YCR022C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene [Source:SGD;Acc:S000000616]					
YCR023C	YCR023C	Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene [Source:SGD;Acc:S000000617]	biological_process, transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane	molecular_function		
YCR024C	SLM5	Mitochondrial asparaginyl-tRNA synthetase [Source:SGD;Acc:S000000618]	asparaginyl-tRNA aminoacylation, aspartyl-tRNA aminoacylation, mitochondrial asparaginyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, asparagine-tRNA ligase activity, aspartate-tRNA ligase activity, ligase activity, nucleic acid binding, nucleotide binding		
YCR024C-A	PMP1	Small single-membrane span proteolipid that functions as a regulatory subunit of the plasma membrane H(+)-ATPase Pma1p, forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines [Source:SGD;Acc:S000000619]	cation transport	integral to membrane, membrane, plasma membrane	enzyme regulator activity		
YCR024C-B	YCR024C-B	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028818]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YCR025C	YCR025C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene [Source:SGD;Acc:S000000620]					
YCR026C	NPP1	Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation [Source:SGD;Acc:S000000621]	cellular response to phosphate starvation, metabolic process, nucleoside triphosphate metabolic process, phosphate metabolic process	cellular_component, integral to membrane, membrane	catalytic activity, hydrolase activity, nucleoside-triphosphatase activity, nucleoside-triphosphate diphosphatase activity, nucleotide diphosphatase activity, phosphodiesterase I activity		
YCR027C	RHB1	Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins [Source:SGD;Acc:S000000622]	arginine transport, lysine transport, retrograde transport, endosome to Golgi, signal transduction, small GTPase mediated signal transduction	extrinsic to plasma membrane, membrane, plasma membrane	GTP binding, GTPase activity, nucleotide binding		
YCR028C	FEN2	Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph [Source:SGD;Acc:S000000623]	endocytosis, pantothenate transmembrane transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	pantothenate transmembrane transporter activity		
YCR028C-A	RIM1	Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication [Source:SGD;Acc:S000007222]	DNA replication, mitochondrial DNA replication, mitochondrial genome maintenance	mitochondrial nucleoid, mitochondrion	DNA binding, single-stranded DNA binding		
YCR030C	SYP1	Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization [Source:SGD;Acc:S000000626]	actin cortical patch assembly, septin cytoskeleton organization	cellular bud neck, cellular bud tip, mating projection base, mating projection tip	molecular_function		
YCR031C	RPS14A	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins [Source:SGD;Acc:S000000627]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit assembly, ribosome biogenesis, translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small-subunit processome	mRNA binding, structural constituent of ribosome		
YCR032W	BPH1	PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting [Source:SGD;Acc:S000000628]	fungal-type cell wall organization, intracellular protein transport, response to pH	cytoplasm, membrane, mitochondrion, peripheral to membrane of membrane fraction, soluble fraction	molecular_function, protein binding		
YCR033W	SNT1	Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000000629]	histone deacetylation, negative regulation of meiosis, positive regulation of stress-activated MAPK cascade	Rpd3L-Expanded complex, Set3 complex, nucleus	DNA binding, molecular_function, protein binding		
YCR034W	FEN1	Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway [Source:SGD;Acc:S000000630]	fatty acid biosynthetic process, fatty acid elongation, lipid biosynthetic process, sphingolipid biosynthetic process, vesicle-mediated transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	fatty acid elongase activity		
YCR035C	RRP43	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8) [Source:SGD;Acc:S000000631]	RNA processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ncRNA 3'-end processing, nonfunctional rRNA decay, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, polyadenylation-dependent snoRNA 3'-end processing, rRNA processing	cytoplasm, cytoplasmic exosome (RNase complex), exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus	3'-5'-exoribonuclease activity, RNA binding, molecular_function		
YCR036W	RBK1	Putative ribokinase [Source:SGD;Acc:S000000632]	D-ribose metabolic process, carbohydrate metabolic process	cytoplasm, nucleus	ATP binding, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, ribokinase activity, transferase activity		
YCR037C	PHO87	Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments [Source:SGD;Acc:S000000633]	citrate transport, phosphate transport, transmembrane transport, transport	integral to membrane, membrane	citrate transmembrane transporter activity, inorganic phosphate transmembrane transporter activity		
YCR038C	BUD5	GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types [Source:SGD;Acc:S000000634]	axial cellular bud site selection, bipolar cellular bud site selection, cellular bud site selection, pseudohyphal growth, regulation of small GTPase mediated signal transduction, small GTPase mediated signal transduction	cell cortex, cellular bud neck, cytoplasm, incipient cellular bud site, intracellular	Ras guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity		
YCR038W-A	YCR038W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene BUD5/YCR038C; identified by homology with hemiascomycetous yeast species [Source:SGD;Acc:S000007597]					
YCR039C	MATALPHA2	Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette [Source:SGD;Acc:S000000635]	donor selection, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, regulation of transcription, mating-type specific	nucleus	DNA bending activity, DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, transcription corepressor activity		
YCR040W	MATALPHA1	Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette [Source:SGD;Acc:S000000636]	positive regulation of transcription, mating-type specific, regulation of transcription from RNA polymerase II promoter, regulation of transcription, mating-type specific, single fertilization	nucleus	DNA bending activity, DNA binding, mating pheromone activity, sequence-specific DNA binding, transcription coactivator activity		
YCR041W	YCR041W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000637]					
YCR042C	TAF2	TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation [Source:SGD;Acc:S000000638]	RNA polymerase II transcriptional preinitiation complex assembly	nucleus, transcription factor TFIID complex	chromatin binding		
YCR043C	YCR043C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene [Source:SGD;Acc:S000000639]	biological_process	Golgi apparatus, mating projection tip	molecular_function		
YCR044C	PER1	Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 [Source:SGD;Acc:S000000640]	GPI anchor biosynthetic process, cellular manganese ion homeostasis	endoplasmic reticulum, endoplasmic reticulum membrane, fungal-type vacuole membrane, integral to membrane, membrane	molecular_function		
YCR045C	RRT12	Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores [Source:SGD;Acc:S000000641]	ascospore wall assembly, negative regulation of catalytic activity, proteolysis	ascospore wall, nuclear envelope	hydrolase activity, identical protein binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity		
YCR045W-A	YCR045W-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR045C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028607]					
YCR046C	IMG1	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome [Source:SGD;Acc:S000000642]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YCR047C	BUD23	Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern [Source:SGD;Acc:S000000643]	cellular bud site selection, endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), metabolic process, rRNA (guanine-N7)-methylation, ribosomal small subunit export from nucleus	cytoplasm, nucleolus, nucleus	S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, rRNA (guanine) methyltransferase activity, transferase activity		
YCR047W-A	YCR047W-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028608]					
YCR048W	ARE1	Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen [Source:SGD;Acc:S000000644]	sterol metabolic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	O-acyltransferase activity, acyltransferase activity, cholesterol O-acyltransferase activity, ergosterol O-acyltransferase activity, lanosterol O-acyltransferase activity, transferase activity		
YCR049C	YCR049C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000645]					
YCR050C	YCR050C	Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein [Source:SGD;Acc:S000000646]	biological_process	cellular_component	molecular_function		
YCR051W	YCR051W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene [Source:SGD;Acc:S000000647]	biological_process	cytoplasm, nucleus	molecular_function, protein binding		
YCR052W	RSC6	Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p [Source:SGD;Acc:S000000648]	ATP-dependent chromatin remodeling, G2/M transition of mitotic cell cycle, chromatin modification, nucleosome disassembly, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	DNA-dependent ATPase activity, protein binding		
YCR053W	THR4	Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway [Source:SGD;Acc:S000000649]	cellular amino acid biosynthetic process, cellular amino acid metabolic process, endocytosis, metabolic process, threonine biosynthetic process, threonine metabolic process	cytoplasm, nucleus	catalytic activity, lyase activity, pyridoxal phosphate binding, threonine synthase activity		
YCR054C	CTR86	Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis [Source:SGD;Acc:S000000650]	biological_process, cellular amino acid biosynthetic process, threonine biosynthetic process	cytoplasm	binding, molecular_function		
YCR057C	PWP2	Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis [Source:SGD;Acc:S000000653]	cytokinesis, endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), establishment of cell polarity, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, Pwp2p-containing subcomplex of 90S preribosome, cytoplasm, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	protein binding, snoRNA binding		
YCR059C	YIH1	Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene [Source:SGD;Acc:S000000655]	regulation of cellular amino acid metabolic process, regulation of translation	cytoplasm, nucleus	actin binding, molecular_function, protein binding		
YCR060W	TAH1	HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs [Source:SGD;Acc:S000000656]	protein folding	cytoplasm, nucleus	binding, chaperone binding, protein binding		
YCR061W	YCR061W	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000000657]	regulation of cell size	cytoplasm, integral to membrane, membrane	molecular_function		
YCR063W	BUD31	Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern [Source:SGD;Acc:S000000659]	RNA splicing, cell cycle, cellular bud site selection, nuclear mRNA splicing, via spliceosome	U2 snRNP, nucleus	molecular_function		
YCR064C	YCR064C	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 [Source:SGD;Acc:S000000660]					
YCR065W	HCM1	Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role [Source:SGD;Acc:S000000661]	regulation of transcription from RNA polymerase II promoter, regulation of transcription involved in S phase of mitotic cell cycle, regulation of transcription, DNA-dependent, spindle pole body organization	cytoplasm, nuclear chromatin, nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YCR066W	RAD18	E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair [Source:SGD;Acc:S000000662]	DNA repair, error-free postreplication DNA repair, error-free translesion synthesis, error-prone translesion synthesis, protein monoubiquitination, response to DNA damage stimulus	nuclear chromatin, nucleus	DNA binding, damaged DNA binding, ligase activity, metal ion binding, nucleic acid binding, protein binding, single-stranded DNA binding, single-stranded DNA-dependent ATPase activity, ubiquitin-protein ligase activity, zinc ion binding		
YCR067C	SED4	Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p [Source:SGD;Acc:S000000663]	positive regulation of GTPase activity, protein transport, regulation of COPII vesicle coating, transport, vesicle-mediated transport	Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	GTPase activator activity, Sar GTPase activator activity, protein binding		
YCR068W	ATG15	Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway [Source:SGD;Acc:S000000664]	autophagy, lipid catabolic process, lipid metabolic process, membrane disassembly, multivesicular body membrane disassembly, piecemeal microautophagy of nucleus, vacuolar protein processing	Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, integral to membrane, late endosome membrane, membrane, multivesicular body membrane, vacuolar lumen	hydrolase activity, lipase activity, triglyceride lipase activity		
YCR069W	CPR4	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway [Source:SGD;Acc:S000000665]	biological_process, protein folding	integral to membrane, membrane	isomerase activity, peptidyl-prolyl cis-trans isomerase activity		
YCR071C	IMG2	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000000667]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YCR072C	RSA4	WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus [Source:SGD;Acc:S000000668]	ribosomal large subunit assembly	nucleolus, ribosome	molecular_function, protein binding		
YCR073C	SSK22	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p [Source:SGD;Acc:S000000669]	MAPKKK cascade involved in osmosensory signaling pathway, protein phosphorylation	cellular_component	ATP binding, MAP kinase kinase kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YCR073W-A	SOL2	Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p [Source:SGD;Acc:S000000718]	carbohydrate metabolic process, pentose-phosphate shunt, tRNA export from nucleus	cytoplasm, cytosol	6-phosphogluconolactonase activity, molecular_function		
YCR075C	ERS1	Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains [Source:SGD;Acc:S000000671]	L-cystine transport, transmembrane transport, transport	endosome, endosome membrane, fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	L-cystine transmembrane transporter activity		
YCR075W-A	YCR075W-A	Putative protein of unknown function; identified by homology to Ashbya gossypii [Source:SGD;Acc:S000028519]	biological_process	cellular_component	molecular_function		
YCR076C	YCR076C	Putative protein of unknown function; YCR076C is not an essential gene [Source:SGD;Acc:S000000672]	biological_process	cellular_component	molecular_function		
YCR077C	PAT1	Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p [Source:SGD;Acc:S000000673]	cell cycle, cell division, chromosome segregation, cytoplasmic mRNA processing body assembly, deadenylation-dependent decapping of nuclear-transcribed mRNA, formation of translation preinitiation complex, negative regulation of translational initiation, regulation of translational initiation	cytoplasm, cytoplasmic mRNA processing body, cytosolic small ribosomal subunit	molecular_function		
YCR079W	PTC6	Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase [Source:SGD;Acc:S000002133]	macroautophagy, mitochondrion degradation, positive regulation of catalytic activity, protein dephosphorylation	mitochondrial intermembrane space, mitochondrial matrix, mitochondrion	catalytic activity, hydrolase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YCR081C-A	YCR081C-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028609]					
YCR081W	SRB8	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression [Source:SGD;Acc:S000000677]	negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription by galactose, regulation of transcription from RNA polymerase II promoter	mediator complex, nucleus			
YCR082W	AHC2	Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus [Source:SGD;Acc:S000000678]	biological_process	cytoplasm, nucleus	molecular_function		
YCR083W	TRX3	Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p [Source:SGD;Acc:S000000679]	cell redox homeostasis, cellular response to oxidative stress, electron transport chain, glycerol ether metabolic process, transport	mitochondrion	disulfide oxidoreductase activity, electron carrier activity, protein disulfide oxidoreductase activity		
YCR084C	TUP1	General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes [Source:SGD;Acc:S000000680]	nucleosome positioning	nucleus, transcriptional repressor complex	protein binding, ubiquitin binding		
YCR085W	YCR085W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000681]					
YCR086W	CSM1	Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation [Source:SGD;Acc:S000000682]	homologous chromosome segregation, meiosis, meiotic chromosome segregation, protein localization to nucleolar rDNA repeats, rDNA condensation	chromosome, centromeric region, monopolin complex, nuclear envelope, nucleolus, nucleus	molecular_function		
YCR087C-A	YCR087C-A	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene [Source:SGD;Acc:S000007223]	biological_process	intracellular, nucleolus, nucleus	metal ion binding, molecular_function, zinc ion binding		
YCR087W	YCR087W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene [Source:SGD;Acc:S000000683]					
YCR088W	ABP1	Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization [Source:SGD;Acc:S000000684]	actin cortical patch assembly, establishment of cell polarity, protein localization	actin cortical patch, cell cortex, cytoplasm, cytoskeleton, intracellular, mating projection tip	actin binding, actin filament binding, protein binding		
YCR089W	FIG2	Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating [Source:SGD;Acc:S000000685]	cell adhesion, cell morphogenesis involved in conjugation with cellular fusion, cellular cell wall organization, conjugation, cytogamy, regulation of cell shape, response to pheromone	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, mating projection, membrane	molecular_function		
YCR090C	YCR090C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene [Source:SGD;Acc:S000000686]	biological_process	cytoplasm, nucleus	molecular_function		
YCR091W	KIN82	Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p [Source:SGD;Acc:S000000687]	phospholipid translocation, protein phosphorylation, response to pheromone	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YCR092C	MSH3	Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability [Source:SGD;Acc:S000000688]	DNA recombination, DNA repair, meiotic mismatch repair, mismatch repair, mitotic recombination, removal of nonhomologous ends, response to DNA damage stimulus	MutSbeta complex, cytoplasm, nucleus	ATP binding, DNA binding, DNA insertion or deletion binding, Y-form DNA binding, double-strand/single-strand DNA junction binding, loop DNA binding, mismatched DNA binding, nucleotide binding		
YCR093W	CDC39	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor [Source:SGD;Acc:S000000689]	negative regulation of transcription from RNA polymerase II promoter, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, nuclear-transcribed mRNA poly(A) tail shortening, pseudohyphal growth, regulation of cell cycle, regulation of transcription from RNA polymerase II promoter, response to pheromone involved in conjugation with cellular fusion, transcription elongation from RNA polymerase II promoter	CCR4-NOT core complex, cytoplasm, nucleus	molecular_function		
YCR094W	CDC50	Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Ynr048wp and Lem3p [Source:SGD;Acc:S000000690]	actin cortical patch localization, endocytosis, intracellular protein transport, phospholipid translocation	endosome, integral to membrane, integral to membrane of membrane fraction, late endosome, late endosome membrane, membrane, trans-Golgi network	phospholipid-translocating ATPase activity		
YCR095C	OCA4	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts [Source:SGD;Acc:S000000691]	biological_process	cytoplasm	molecular_function		
YCR095W-A	YCR095W-A	Putative protein of unknown function [Source:SGD;Acc:S000029724]	biological_process	cellular_component	molecular_function		
YCR096C	HMRA2	Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system [Source:SGD;Acc:S000000692]	biological_process, regulation of transcription, DNA-dependent	cellular_component, nucleus	DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YCR097W	HMRA1	Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells [Source:SGD;Acc:S000000694]	regulation of transcription, DNA-dependent, regulation of transcription, mating-type specific	nucleus	DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, transcription corepressor activity		
YCR097W-A	YCR097W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein [Source:SGD;Acc:S000007632]					
YCR098C	GIT1	Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability [Source:SGD;Acc:S000000695]	glycerophosphodiester transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	glycerophosphodiester transmembrane transporter activity, transporter activity		
YCR099C	YCR099C	Putative protein of unknown function [Source:SGD;Acc:S000000696]	biological_process	cellular_component	molecular_function		
YCR100C	YCR100C	Putative protein of unknown function [Source:SGD;Acc:S000000697]	biological_process	cellular_component	molecular_function		
YCR101C	YCR101C	Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene [Source:SGD;Acc:S000000698]	biological_process	membrane fraction	molecular_function		
YCR102C	YCR102C	Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family [Source:SGD;Acc:S000000699]	metabolic process, oxidation-reduction process, response to copper ion	cellular_component	binding, catalytic activity, molecular_function, oxidoreductase activity, zinc ion binding		
YCR102W-A	YCR102W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007231]					
YCR104W	PAU3	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme [Source:SGD;Acc:S000000701]	biological_process, response to stress	cellular_component, integral to membrane, membrane	molecular_function		
YCR105W	ADH7	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance [Source:SGD;Acc:S000000702]	alcohol metabolic process, metabolic process, oxidation-reduction process	soluble fraction	alcohol dehydrogenase (NADP+) activity, binding, catalytic activity, cofactor binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, zinc ion binding		
YCR106W	RDS1	Zinc cluster transcription factor involved in conferring resistance to cycloheximide [Source:SGD;Acc:S000000703]	regulation of transcription, DNA-dependent, response to xenobiotic stimulus	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YCR107W	AAD3	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role [Source:SGD;Acc:S000000704]	cellular aldehyde metabolic process, oxidation-reduction process	cellular_component	aryl-alcohol dehydrogenase activity, oxidoreductase activity		
YCR108C	YCR108C	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028536]	biological_process	cellular_component	molecular_function		
YDL001W	RMD1	Cytoplasmic protein required for sporulation [Source:SGD;Acc:S000002159]	biological_process, meiosis, sporulation resulting in formation of a cellular spore	cytoplasm	molecular_function		
YDL002C	NHP10	Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair [Source:SGD;Acc:S000002160]	double-strand break repair, nucleosome mobilization	Ino80 complex, nucleus	DNA binding, DNA end binding, loop DNA binding, protein binding		
YDL003W	MCD1	Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase [Source:SGD;Acc:S000002161]	apoptosis, cell cycle, cell division, chromosome segregation, double-strand break repair, establishment of mitotic sister chromatid cohesion, mitosis, mitotic chromosome condensation, response to DNA damage stimulus	chromosome, chromosome, centromeric region, condensed nuclear chromosome, mitochondrion, nuclear chromosome, nuclear mitotic cohesin complex, nucleus	chromatin binding		
YDL004W	ATP16	Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [Source:SGD;Acc:S000002162]	ATP biosynthetic process, ATP synthesis coupled proton transport, ion transport, proton transport, transport	membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase, central stalk, mitochondrion, proton-transporting ATP synthase complex, catalytic core F(1)	ATPase activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, proton-transporting ATPase activity, rotational mechanism		
YDL005C	MED2	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000002163]	transcription from RNA polymerase II promoter	mediator complex, nucleus			
YDL006W	PTC1	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation [Source:SGD;Acc:S000002164]	inactivation of MAPK activity involved in osmosensory signaling pathway, mitochondrion inheritance, pheromone-dependent signal transduction involved in conjugation with cellular fusion, protein dephosphorylation, response to stress, tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm, nucleus, protein serine/threonine phosphatase complex	catalytic activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YDL007C-A	YDL007C-A	Putative protein of unknown function [Source:SGD;Acc:S000113557]	biological_process	cellular_component	molecular_function		
YDL007W	RPT2	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle [Source:SGD;Acc:S000002165]	peptide catabolic process, positive regulation of protein catabolic process, proteasome regulatory particle assembly, protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus, proteasome complex, proteasome regulatory particle, base subcomplex	ATP binding, ATPase activity, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding		
YDL008W	APC11	Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000002166]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, cyclin catabolic process, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, protein ubiquitination	anaphase-promoting complex	ligase activity, metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YDL009C	YDL009C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YDL010W; YDL009C is not an essential gene [Source:SGD;Acc:S000002167]					
YDL010W	GRX6	Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX7 [Source:SGD;Acc:S000002168]	cell redox homeostasis, cellular response to oxidative stress	Golgi apparatus, Golgi lumen, cis-Golgi network, endoplasmic reticulum membrane, fungal-type vacuole, integral to membrane, vacuole	2 iron, 2 sulfur cluster binding, electron carrier activity, glutathione-disulfide reductase activity, iron ion binding, iron-sulfur cluster binding, metal ion binding, protein disulfide oxidoreductase activity, protein homodimerization activity		
YDL011C	YDL011C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W [Source:SGD;Acc:S000002169]					
YDL012C	YDL012C	Tail-anchored plasma membrane protein containing a conserved CYSTM module, possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype [Source:SGD;Acc:S000002170]	biological_process	membrane, plasma membrane	molecular_function		
YDL013W	SLX5	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers [Source:SGD;Acc:S000002171]	DNA repair, protein sumoylation, protein ubiquitination, response to DNA damage stimulus, telomere maintenance	nucleolus, nucleus, ubiquitin ligase complex	SUMO binding, ligase activity, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YDL014W	NOP1	Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin [Source:SGD;Acc:S000002172]	RNA methylation, box C/D snoRNA 3'-end processing, rRNA methylation, rRNA processing, ribosome biogenesis, snoRNA processing, tRNA processing	90S preribosome, box C/D snoRNP complex, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small-subunit processome	RNA binding, methyltransferase activity, transferase activity		
YDL015C	TSC13	Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p [Source:SGD;Acc:S000002173]	lipid biosynthetic process, lipid metabolic process, oxidation-reduction process, very long-chain fatty acid metabolic process	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion	oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, trans-2-enoyl-CoA reductase (NADPH) activity		
YDL016C	YDL016C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication [Source:SGD;Acc:S000002174]					
YDL017W	CDC7	DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression [Source:SGD;Acc:S000002175]	DNA-dependent DNA replication initiation, cell cycle, cell division, double-strand break repair via break-induced replication, meiosis, mitosis, negative regulation of exit from mitosis, protein phosphorylation, regulation of chromatin silencing at telomere	Dbf4-dependent protein kinase complex, nucleus	ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDL018C	ERP3	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport [Source:SGD;Acc:S000002176]	protein transport, transport, vesicle-mediated transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YDL019C	OSH2	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability [Source:SGD;Acc:S000002177]	endocytosis, exocytosis, lipid transport, maintenance of cell polarity, steroid metabolic process, sterol transport, transport	cellular bud neck, cortical endoplasmic reticulum, endoplasmic reticulum, membrane, plasma membrane	1-phosphatidylinositol binding, lipid binding, oxysterol binding, protein binding, sterol transporter activity		
YDL020C	RPN4	Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses [Source:SGD;Acc:S000002178]	G2/M transition of mitotic cell cycle, positive regulation of DNA repair, positive regulation of protein catabolic process, response to arsenic-containing substance	intracellular, nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YDL021W	GPM2	Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event [Source:SGD;Acc:S000002179]	biological_process, glycolysis, metabolic process	cytoplasm, cytosol	catalytic activity, intramolecular transferase activity, phosphotransferases, isomerase activity, molecular_function, phosphoglycerate mutase activity		
YDL022C-A	YDL022C-A	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028537]					
YDL022W	GPD1	NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p [Source:SGD;Acc:S000002180]	NADH oxidation, carbohydrate metabolic process, glycerol-3-phosphate catabolic process, glycerol-3-phosphate metabolic process, intracellular accumulation of glycerol, metabolic process, oxidation-reduction process, response to stress	cytoplasm, cytosol, glycerol-3-phosphate dehydrogenase complex, nucleus, peroxisome	NAD binding, binding, catalytic activity, coenzyme binding, glycerol-3-phosphate dehydrogenase [NAD+] activity, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein homodimerization activity		
YDL023C	YDL023C	Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance [Source:SGD;Acc:S000002181]					
YDL024C	DIA3	Protein of unknown function, involved in invasive and pseudohyphal growth [Source:SGD;Acc:S000002182]	invasive growth in response to glucose limitation, pseudohyphal growth	fungal-type cell wall	acid phosphatase activity, hydrolase activity, phosphatase activity		
YDL025C	RTK1	Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1 [Source:SGD;Acc:S000002183]	biological_process, protein phosphorylation	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDL025W-A	YDL025W-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the ORF YDL025C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028610]					
YDL026W	YDL026W	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002184]					
YDL027C	YDL027C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene [Source:SGD;Acc:S000002185]	biological_process	integral to membrane, membrane, mitochondrion	molecular_function		
YDL028C	MPS1	Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p [Source:SGD;Acc:S000002186]	mitotic cell cycle spindle assembly checkpoint, protein phosphorylation, sister chromatid biorientation, spindle assembly, spindle pole body duplication in nuclear envelope	condensed nuclear chromosome kinetochore, spindle pole body	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, transferase activity		
YDL029W	ARP2	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity [Source:SGD;Acc:S000002187]	ATP catabolic process, Arp2/3 complex-mediated actin nucleation, actin filament organization, ascospore wall assembly, establishment of mitochondrion localization, mitochondrion inheritance	Arp2/3 protein complex, actin cortical patch, cytoplasm, cytoskeleton, mitochondrion	ATP binding, ATPase activity, actin binding, nucleotide binding		
YDL030W	PRP9	Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex [Source:SGD;Acc:S000002188]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U2 snRNP, U2-type prespliceosome, intracellular, nucleus, spliceosomal complex	RNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YDL031W	DBP10	Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis [Source:SGD;Acc:S000002189]	rRNA processing, ribosomal large subunit assembly, ribosome biogenesis	nucleolus, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, nucleic acid binding, nucleotide binding		
YDL032W	YDL032W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene [Source:SGD;Acc:S000002190]					
YDL033C	SLM3	tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) [Source:SGD;Acc:S000002191]	mitochondrial tRNA thio-modification, tRNA processing	cytoplasm, mitochondrion	ATP binding, RNA binding, nucleotide binding, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity, tRNA binding, transferase activity		
YDL034W	YDL034W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene [Source:SGD;Acc:S000002192]					
YDL035C	GPR1	Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis [Source:SGD;Acc:S000002193]	G-protein coupled receptor protein signaling pathway, detection of glucose, detection of sucrose stimulus, glucose mediated signaling pathway, hexose mediated signaling, invasive growth in response to glucose limitation, pseudohyphal growth, replicative cell aging, signal transduction, sucrose mediated signaling	integral to membrane, membrane, plasma membrane	G-protein coupled receptor activity, glucose binding, receptor activity, signal transducer activity		
YDL036C	PUS9	Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence [Source:SGD;Acc:S000002194]	RNA modification, pseudouridine synthesis, tRNA processing, tRNA pseudouridine synthesis	cytoplasm, mitochondrion, nucleus	RNA binding, isomerase activity, pseudouridine synthase activity		
YDL037C	BSC1	Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression [Source:SGD;Acc:S000002195]	biological_process	cellular_component	molecular_function		
YDL039C	PRM7	Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements [Source:SGD;Acc:S000002197]	conjugation with cellular fusion	integral to membrane	molecular_function		
YDL040C	NAT1	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing [Source:SGD;Acc:S000002198]	N-terminal protein amino acid acetylation	NatA complex, cytoplasm, cytosolic ribosome, mitochondrion	binding, peptide alpha-N-acetyltransferase activity		
YDL041W	YDL041W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C [Source:SGD;Acc:S000002199]					
YDL042C	SIR2	Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication [Source:SGD;Acc:S000002200]	DNA repair, chromatin assembly or disassembly, chromatin modification, chromatin silencing, chromatin silencing at rDNA, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, chronological cell aging, double-strand break repair via nonhomologous end joining, loss of chromatin silencing involved in replicative cell aging, negative regulation of DNA recombination, negative regulation of DNA replication, protein deacetylation, regulation of transcription, DNA-dependent, replicative cell aging, response to DNA damage stimulus	RENT complex, chromatin silencing complex, nuclear heterochromatin, nuclear telomere cap complex, nuclear telomeric heterochromatin, nucleolus, nucleus	NAD binding, NAD+ binding, NAD-dependent histone deacetylase activity, NAD-dependent histone deacetylase activity (H3-K14 specific), NAD-dependent histone deacetylase activity (H3-K9 specific), NAD-dependent histone deacetylase activity (H4-K16 specific), hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, metal ion binding, nucleosome binding, zinc ion binding		
YDL043C	PRP11	Subunit of the SF3a splicing factor complex, required for spliceosome assembly [Source:SGD;Acc:S000002201]	RNA splicing, mRNA processing, spliceosome assembly	U2 snRNP, U2-type prespliceosome, intracellular, nucleus, spliceosomal complex	RNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YDL044C	MTF2	Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription [Source:SGD;Acc:S000002202]	mRNA processing, translation	mitochondrial matrix, mitochondrion	RNA binding		
YDL045C	FAD1	Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin [Source:SGD;Acc:S000002203]	FAD biosynthetic process, metabolic process	cytoplasm	ATP binding, FMN adenylyltransferase activity, nucleotide binding, nucleotidyltransferase activity, transferase activity		
YDL045W-A	MRP10	Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000006430]	mitochondrial respiratory chain complex assembly, mitochondrial translation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDL046W	NPC2	Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes [Source:SGD;Acc:S000002204]	intracellular sterol transport, lipid transport, transport	fungal-type vacuole, fungal-type vacuole lumen, vacuole	molecular_function		
YDL047W	SIT4	Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization [Source:SGD;Acc:S000002205]	DNA repair, G1/S transition of mitotic cell cycle, TOR signaling cascade, actin cytoskeleton organization, cell cycle, cell division, cellular response to oxidative stress, dephosphorylation, fungal-type cell wall organization, intracellular protein kinase cascade, mitosis, replicative cell aging, tRNA wobble uridine modification	cytoplasm, nucleus	hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YDL048C	STP4	Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p [Source:SGD;Acc:S000002206]	biological_process	cytoplasm, intracellular, mitochondrion, nucleus	metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YDL049C	KNH1	Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance [Source:SGD;Acc:S000002207]	1,6-beta-glucan biosynthetic process, cell wall biogenesis, cellular cell wall organization	cell wall, extracellular region, fungal-type cell wall	molecular_function		
YDL050C	YDL050C	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002208]					
YDL051W	LHP1	RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen [Source:SGD;Acc:S000002209]	RNA processing, tRNA processing	nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex	RNA binding, nucleic acid binding, nucleotide binding, tRNA binding		
YDL052C	SLC1	1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes [Source:SGD;Acc:S000002210]	glycerophospholipid biosynthetic process, metabolic process, phospholipid biosynthetic process	integral to membrane, lipid particle, membrane	1-acylglycerol-3-phosphate O-acyltransferase activity, acyltransferase activity, transferase activity		
YDL053C	PBP4	Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay [Source:SGD;Acc:S000002211]	biological_process	cytoplasm, nucleus, stress granule	molecular_function		
YDL054C	MCH1	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport [Source:SGD;Acc:S000002212]	transmembrane transport, transport	integral to membrane, membrane, vacuolar membrane, vacuole	transporter activity		
YDL055C	PSA1	GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure [Source:SGD;Acc:S000002213]	GDP-mannose biosynthetic process, biosynthetic process, cell cycle, cell wall mannoprotein biosynthetic process, protein glycosylation	cytoplasm	GTP binding, mannose-1-phosphate guanylyltransferase activity, nucleotide binding, nucleotidyltransferase activity, transferase activity		
YDL056W	MBP1	Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes [Source:SGD;Acc:S000002214]	regulation of transcription involved in G1/S phase of mitotic cell cycle, regulation of transcription, DNA-dependent	MBF transcription complex, nucleus	DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YDL057W	YDL057W	Putative protein of unknown function; YDL057W is not an essential gene [Source:SGD;Acc:S000002215]	biological_process	cellular_component	molecular_function		
YDL058W	USO1	Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex [Source:SGD;Acc:S000002216]	ER to Golgi vesicle-mediated transport, Golgi vesicle docking, SNARE complex assembly, intracellular protein transport, protein transport, transport, vesicle fusion with Golgi apparatus	ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, endoplasmic reticulum, endoplasmic reticulum membrane, membrane	binding, molecular_function, protein transporter activity		
YDL059C	RAD59	Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p [Source:SGD;Acc:S000002217]	DNA recombination, DNA repair, double-strand break repair via break-induced replication, double-strand break repair via single-strand annealing, response to DNA damage stimulus, telomere maintenance via recombination	nucleus	DNA strand annealing activity, protein binding		
YDL060W	TSR1	Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles [Source:SGD;Acc:S000002218]	rRNA processing, ribosome biogenesis	90S preribosome, cytoplasm, nucleolus, nucleus	ribonucleoprotein binding		
YDL061C	RPS29B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins [Source:SGD;Acc:S000002219]	translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	metal ion binding, structural constituent of ribosome		
YDL062W	YDL062W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential [Source:SGD;Acc:S000002220]					
YDL063C	YDL063C	Protein required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000002221]	ribosomal large subunit biogenesis	cytoplasm, nucleus	binding, molecular_function		
YDL064W	UBC9	SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) [Source:SGD;Acc:S000002222]	G2/M transition of mitotic cell cycle, cell cycle, cell division, mitosis, mitotic spindle elongation, post-translational protein modification, protein sumoylation, regulation of protein metabolic process	condensed nuclear chromosome, nucleus	ATP binding, SUMO ligase activity, acid-amino acid ligase activity, ligase activity, nucleotide binding, small conjugating protein ligase activity		
YDL065C	PEX19	Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane [Source:SGD;Acc:S000002223]	ER-dependent peroxisome organization, peroxisome organization, protein exit from endoplasmic reticulum, protein import into peroxisome membrane, protein stabilization	cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, peroxisomal membrane, peroxisome	peroxisome membrane targeting sequence binding, protein binding		
YDL066W	IDP1	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes [Source:SGD;Acc:S000002224]	glutamate biosynthetic process, glyoxylate cycle, isocitrate metabolic process, oxidation-reduction process, tricarboxylic acid cycle	mitochondrial nucleoid, mitochondrion	NAD binding, isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YDL067C	COX9	Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain [Source:SGD;Acc:S000002225]	mitochondrial electron transport, cytochrome c to oxygen, oxidation-reduction process, respiratory electron transport chain	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial respiratory chain, mitochondrial respiratory chain complex IV, mitochondrion	cytochrome-c oxidase activity, oxidoreductase activity		
YDL068W	YDL068W	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002226]					
YDL069C	CBS1	Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader [Source:SGD;Acc:S000002227]	positive regulation of mitochondrial translation, regulation of translation	extrinsic to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrial ribosome, mitochondrion	translation regulator activity		
YDL070W	BDF2	Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p [Source:SGD;Acc:S000002228]	DNA repair, biological_process, response to DNA damage stimulus, sporulation resulting in formation of a cellular spore	cytoplasm, nucleus	histone acetyl-lysine binding, histone binding, protein binding		
YDL071C	YDL071C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W [Source:SGD;Acc:S000002229]					
YDL072C	YET3	Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein [Source:SGD;Acc:S000002230]	biological_process, intracellular protein transport, protein transport, transport, vesicle-mediated transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YDL073W	YDL073W	Putative protein of unknown function; YDL073W is not an essential gene [Source:SGD;Acc:S000002231]	biological_process	cellular_component	molecular_function		
YDL074C	BRE1	E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control [Source:SGD;Acc:S000002232]	chromatin modification, chromatin silencing at telomere, double-strand break repair via homologous recombination, histone monoubiquitination, intra-S DNA damage checkpoint, meiotic DNA double-strand break formation, mitotic cell cycle G1/S transition DNA damage checkpoint, transcription from RNA polymerase II promoter	intracellular, nuclear chromatin, nucleus	ligase activity, metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YDL075W	RPL31A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality [Source:SGD;Acc:S000002233]	regulation of translational fidelity, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDL076C	RXT3	Subunit of the RPD3L complex; involved in histone deacetylation [Source:SGD;Acc:S000002234]	chromatin modification, histone deacetylation, negative regulation of transcription from RNA polymerase I promoter	Rpd3L complex, Rpd3L-Expanded complex, nucleus	molecular_function		
YDL077C	VAM6	Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p [Source:SGD;Acc:S000002235]	piecemeal microautophagy of nucleus, protein transport, regulation of SNARE complex assembly, regulation of vacuole fusion, non-autophagic, transport, vacuole fusion, non-autophagic, vacuole organization	HOPS complex, fungal-type vacuole, fungal-type vacuole membrane, membrane, vacuolar membrane, vacuole	Rab guanyl-nucleotide exchange factor activity, phosphatidylinositol binding		
YDL078C	MDH3	Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle [Source:SGD;Acc:S000002236]	NADH regeneration, carbohydrate metabolic process, cellular carbohydrate metabolic process, fatty acid beta-oxidation, glycolysis, glyoxylate cycle, malate metabolic process, metabolic process, oxidation-reduction process, tricarboxylic acid cycle	peroxisomal matrix, peroxisome	L-malate dehydrogenase activity, binding, catalytic activity, malate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YDL079C	MRK1	Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation [Source:SGD;Acc:S000002237]	protein phosphorylation, regulation of protein catabolic process, response to stress	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDL080C	THI3	Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis [Source:SGD;Acc:S000002238]	branched chain family amino acid catabolic process, branched chain family amino acid catabolic process to alcohol via Ehrlich pathway, leucine catabolic process, positive regulation of transcription from RNA polymerase II promoter, regulation of thiamine biosynthetic process	cytosol, nucleus	carboxy-lyase activity, catalytic activity, lyase activity, magnesium ion binding, metal ion binding, thiamine pyrophosphate binding		
YDL081C	RPP1A	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component [Source:SGD;Acc:S000002239]	translation, translational elongation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDL082W	RPL13A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein [Source:SGD;Acc:S000002240]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDL083C	RPS16B	Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins [Source:SGD;Acc:S000002241]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDL084W	SUB2	Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56 [Source:SGD;Acc:S000002242]	RNA splicing, chromatin silencing at telomere, mRNA 3'-end processing, mRNA export from nucleus, mRNA processing, mRNA transport, nuclear mRNA branch site recognition, nuclear mRNA splicing, via spliceosome, transcription elongation from RNA polymerase II promoter, transcription-coupled nucleotide-excision repair, transport	chromosome, telomeric region, nucleus, spliceosomal complex, transcription export complex	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YDL085C-A	YDL085C-A	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000007588]	biological_process	cytoplasm, nucleus	molecular_function		
YDL085W	NDE2	Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain [Source:SGD;Acc:S000002243]	NADH oxidation, glucose catabolic process to ethanol, oxidation-reduction process	mitochondrial intermembrane space, mitochondrion	NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, flavin adenine dinucleotide binding, oxidoreductase activity		
YDL086C-A	YDL086C-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps uncharacterized ORF YDL086W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028611]					
YDL086W	YDL086W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene [Source:SGD;Acc:S000002244]	biological_process	cytoplasm, mitochondrion	carboxymethylenebutenolidase activity, hydrolase activity		
YDL087C	LUC7	Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA [Source:SGD;Acc:S000002245]	RNA splicing, mRNA processing, mRNA splice site selection	U1 snRNP, U2-type prespliceosome, nucleus, ribonucleoprotein complex, spliceosomal complex	mRNA binding		
YDL088C	ASM4	Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p [Source:SGD;Acc:S000002246]	NLS-bearing substrate import into nucleus, cell cycle, cell division, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, mitosis, nuclear pore organization, protein export from nucleus, protein import into nucleus, docking, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, transmembrane transport, transport	karyopherin docking complex, membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YDL089W	NUR1	Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate [Source:SGD;Acc:S000002247]	maintenance of rDNA	integral to membrane, membrane, nuclear periphery	molecular_function		
YDL090C	RAM1	Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit [Source:SGD;Acc:S000002248]	protein farnesylation	protein farnesyltransferase complex	catalytic activity, metal ion binding, prenyltransferase activity, protein farnesyltransferase activity, transferase activity		
YDL091C	UBX3	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000002249]	biological_process	cytoplasm	molecular_function, protein binding		
YDL092W	SRP14	Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 [Source:SGD;Acc:S000002250]	SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, negative regulation of translational elongation, protein targeting to ER	cytoplasm, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting	7S RNA binding, RNA binding, endoplasmic reticulum signal peptide binding, signal sequence binding		
YDL093W	PMT5	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals [Source:SGD;Acc:S000002251]	protein O-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YDL094C	YDL094C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential [Source:SGD;Acc:S000002252]					
YDL095W	PMT1	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein Ser/Thr residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control [Source:SGD;Acc:S000002253]	ER-associated misfolded protein catabolic process, protein O-linked glycosylation, protein exit from endoplasmic reticulum	dolichyl-phosphate-mannose-protein mannosyltransferase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YDL096C	OPI6	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential [Source:SGD;Acc:S000002254]					
YDL097C	RPN6	Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion [Source:SGD;Acc:S000002255]	proteasome assembly, ubiquitin-dependent protein catabolic process	proteasome complex, proteasome regulatory particle, lid subcomplex, proteasome storage granule	binding, protein binding, structural molecule activity		
YDL098C	SNU23	Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome [Source:SGD;Acc:S000002256]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U4/U6 x U5 tri-snRNP complex, intracellular, nucleus, ribonucleoprotein complex, spliceosomal complex	metal ion binding, molecular_function, zinc ion binding		
YDL099W	BUG1	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes [Source:SGD;Acc:S000002257]	ER to Golgi vesicle-mediated transport, protein secretion, transport, vesicle-mediated transport	cis-Golgi network, cytoplasm	molecular_function		
YDL100C	GET3	Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity [Source:SGD;Acc:S000002258]	cellular metal ion homeostasis, pheromone-dependent signal transduction involved in conjugation with cellular fusion, posttranslational protein targeting to membrane, protein insertion into ER membrane, response to arsenic-containing substance, response to heat, response to metal ion, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	GET complex, Golgi apparatus, cytoplasm, endoplasmic reticulum	ATP binding, ATPase activity, guanyl-nucleotide exchange factor activity, hydrolase activity, metal ion binding, nucleotide binding		
YDL101C	DUN1	Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair [Source:SGD;Acc:S000002259]	DNA damage checkpoint, cell cycle checkpoint, protein phosphorylation, replication fork protection, response to DNA damage stimulus	nucleus	ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDL102W	POL3	Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) [Source:SGD;Acc:S000002260]	DNA replication, DNA replication, removal of RNA primer, RNA-dependent DNA replication, base-excision repair, lagging strand elongation, leading strand elongation, maintenance of fidelity involved in DNA-dependent DNA replication, mismatch repair, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, nucleotide-excision repair, postreplication repair	delta DNA polymerase complex, nucleus, replication fork	DNA binding, DNA-directed DNA polymerase activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, single-stranded DNA specific 3'-5' exodeoxyribonuclease activity, transferase activity		
YDL103C	QRI1	UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis [Source:SGD;Acc:S000002261]	UDP-N-acetylglucosamine biosynthetic process, metabolic process	cytoplasm, nucleus	UDP-N-acetylglucosamine diphosphorylase activity, nucleotidyltransferase activity, transferase activity		
YDL104C	QRI7	Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification [Source:SGD;Acc:S000002262]	mitochondrial tRNA threonylcarbamoyladenosine modification, proteolysis	mitochondrion	endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, molecular_function, peptidase activity, zinc ion binding		
YDL105W	NSE4	Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex [Source:SGD;Acc:S000002263]	DNA recombination, DNA repair, response to DNA damage stimulus	Smc5-Smc6 complex, nucleus	molecular_function		
YDL106C	PHO2	Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p [Source:SGD;Acc:S000002264]	chromatin remodeling, histidine biosynthetic process, positive regulation of DNA binding, positive regulation of phosphate metabolic process, positive regulation of transcription from RNA polymerase II promoter, purine base biosynthetic process, regulation of transcription, DNA-dependent	nucleus	DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YDL107W	MSS2	Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p [Source:SGD;Acc:S000002265]	protein insertion into mitochondrial membrane from inner side	extrinsic to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion	binding, molecular_function		
YDL108W	KIN28	Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters [Source:SGD;Acc:S000002266]	cell cycle, cell division, phosphorylation of RNA polymerase II C-terminal domain, positive regulation of transcription from RNA polymerase II promoter, protein phosphorylation	TFIIK complex, holo TFIIH complex, nucleus	ATP binding, RNA polymerase II carboxy-terminal domain kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDL109C	YDL109C	Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene [Source:SGD;Acc:S000002267]	cellular lipid metabolic process, lipid catabolic process, lipid metabolic process	cellular_component	hydrolase activity, hydrolase activity, acting on ester bonds, molecular_function		
YDL110C	TMA17	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion [Source:SGD;Acc:S000002268]	biological_process	cytoplasm, nucleus, ribosome	molecular_function		
YDL111C	RRP42	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7) [Source:SGD;Acc:S000002269]	RNA processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ncRNA 3'-end processing, nonfunctional rRNA decay, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, polyadenylation-dependent snoRNA 3'-end processing, rRNA catabolic process, rRNA processing	cytoplasm, cytoplasmic exosome (RNase complex), exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleus	3'-5'-exoribonuclease activity, RNA binding, molecular_function		
YDL112W	TRM3	2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs [Source:SGD;Acc:S000002270]	RNA processing, tRNA methylation, tRNA processing	cytoplasm	RNA binding, RNA methyltransferase activity, methyltransferase activity, tRNA (guanine) methyltransferase activity, tRNA (guanosine-2'-O-)-methyltransferase activity, transferase activity		
YDL113C	ATG20	Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate [Source:SGD;Acc:S000002271]	CVT pathway, cell communication, early endosome to Golgi transport, macroautophagy, mitochondrion degradation, protein transport, transport	cytoplasm, endosome, endosome membrane, membrane, peripheral to membrane of membrane fraction, pre-autophagosomal structure	phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding		
YDL114W	YDL114W	Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene [Source:SGD;Acc:S000002272]	biological_process, metabolic process, oxidation-reduction process	cellular_component	binding, catalytic activity, molecular_function, oxidoreductase activity		
YDL114W-A	YDL114W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified based on homology to hemiascomycetous yeasts [Source:SGD;Acc:S000007598]					
YDL115C	IWR1	Protein involved in both basal and regulated transcription from RNA polymerase II (RNAP II) promoters; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin [Source:SGD;Acc:S000002273]	chromatin remodeling	DNA-directed RNA polymerase II, holoenzyme, cytoplasm, nucleus	molecular_function		
YDL116W	NUP84	Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis [Source:SGD;Acc:S000002274]	NLS-bearing substrate import into nucleus, chromosome localization, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear envelope organization, nuclear pore organization, protein export from nucleus, protein transport, rRNA export from nucleus, response to DNA damage stimulus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	Nup107-160 complex, membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YDL117W	CYK3	SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis [Source:SGD;Acc:S000002275]	cell cycle, cell division, cytokinesis	cellular bud neck, cytoplasm	molecular_function, protein binding		
YDL118W	YDL118W	Non-essential protein of unconfirmed function; mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein [Source:SGD;Acc:S000002276]	biological_process	cellular_component	molecular_function		
YDL119C	YDL119C	Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria [Source:SGD;Acc:S000002277]	transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, transporter activity		
YDL120W	YFH1	Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia [Source:SGD;Acc:S000002278]	cellular iron ion homeostasis, glutathione metabolic process, heme biosynthetic process, ion transport, iron ion transport, iron-sulfur cluster assembly, oxidation-reduction process, transport	mitochondrial matrix, mitochondrion	ferrous iron binding, ferroxidase activity, iron chaperone activity, oxidoreductase activity		
YDL121C	YDL121C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein [Source:SGD;Acc:S000002279]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YDL122W	UBP1	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains [Source:SGD;Acc:S000002280]	protein deubiquitination, ubiquitin-dependent protein catabolic process	cytoplasm, endoplasmic reticulum	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YDL123W	SNA4	Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated [Source:SGD;Acc:S000002281]	biological_process	fungal-type vacuole lumen, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YDL124W	YDL124W	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family [Source:SGD;Acc:S000002282]	cellular amide metabolic process, cellular aromatic compound metabolic process, cellular ketone metabolic process, cellular response to oxidative stress, oxidation-reduction process	cytoplasm, nucleus, plasma membrane enriched fraction	alditol:NADP+ 1-oxidoreductase activity, aldo-keto reductase (NADP) activity, alpha-keto amide reductase activity, alpha-keto ester reductase activity, oxidoreductase activity		
YDL125C	HNT1	Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint [Source:SGD;Acc:S000002283]	nucleotide metabolic process	cytoplasm, nucleus	catalytic activity, hydrolase activity, nucleotide binding		
YDL126C	CDC48	ATPase involved in ubiquitin-mediated protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD) [Source:SGD;Acc:S000002284]	ER-associated protein catabolic process, cell cycle, cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process, macroautophagy, mitochondria-associated protein catabolic process, mitotic cell cycle, piecemeal microautophagy of nucleus, protein transport, sister chromatid biorientation, transport, ubiquitin-dependent protein catabolic process, vesicle fusion	Cdc48p-Npl4p-Ufd1p AAA ATPase complex, Doa10p ubiquitin ligase complex, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, mating projection tip, microsome, mitochondrion, nucleus	ATP binding, ATPase activity, binding, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding		
YDL127W	PCL2	Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth [Source:SGD;Acc:S000002285]	G1 phase of mitotic cell cycle, cell cycle, cell division, regulation of cell division, regulation of cyclin-dependent protein kinase activity, regulation of establishment or maintenance of cell polarity, septin ring organization	cellular bud neck, cellular bud tip, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, incipient cellular bud site, nucleus	cyclin-dependent protein kinase regulator activity, protein kinase binding		
YDL128W	VCX1	Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter [Source:SGD;Acc:S000002286]	calcium ion transport, cation transport, cellular calcium ion homeostasis, ion transport, transmembrane transport, transport	fungal-type vacuole, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	calcium:hydrogen antiporter activity, cation transmembrane transporter activity, metal ion binding, potassium:hydrogen antiporter activity		
YDL129W	YDL129W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene [Source:SGD;Acc:S000002287]	biological_process	cytoplasm, nucleus	molecular_function		
YDL130W	RPP1B	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component [Source:SGD;Acc:S000002288]	translation, translational elongation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDL130W-A	STF1	Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein [Source:SGD;Acc:S000007232]	negative regulation of ATPase activity, negative regulation of nucleotide metabolic process	mitochondrial proton-transporting ATP synthase complex, mitochondrion	enzyme inhibitor activity, molecular_function		
YDL131W	LYS21	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p [Source:SGD;Acc:S000002289]	carboxylic acid metabolic process, cellular amino acid biosynthetic process, lysine biosynthetic process, lysine biosynthetic process via aminoadipic acid, metabolic process	mitochondrion, nucleus	catalytic activity, homocitrate synthase activity, transferase activity, transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer		
YDL132W	CDC53	Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation [Source:SGD;Acc:S000002290]	G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, cytoplasm, nucleus	DNA replication origin binding, protein binding, bridging, ubiquitin protein ligase binding, ubiquitin-protein ligase activity		
YDL133C-A	RPL41B	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable [Source:SGD;Acc:S000002293]	translation	cytoplasm, cytosolic large ribosomal subunit, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDL133W	YDL133W	Putative protein of unknown function [Source:SGD;Acc:S000002291]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YDL134C	PPH21	Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis [Source:SGD;Acc:S000002292]	G1/S transition of mitotic cell cycle, actin filament organization, budding cell bud growth, mitotic cell cycle spindle assembly checkpoint, protein dephosphorylation, regulation of translation	protein phosphatase type 2A complex	hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YDL135C	RDI1	Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p and Rho1p [Source:SGD;Acc:S000002294]	actin filament organization, regulation of vacuole fusion, non-autophagic, small GTPase mediated signal transduction	cellular bud neck, cellular bud tip, cytoplasm, cytosol, plasma membrane enriched fraction	GTPase activator activity, Rho GDP-dissociation inhibitor activity		
YDL136W	RPL35B	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein [Source:SGD;Acc:S000002295]	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, preribosome, large subunit precursor, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDL137W	ARF2	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p [Source:SGD;Acc:S000002296]	ER to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, macroautophagy, protein transport, small GTPase mediated signal transduction, transport, vesicle-mediated transport	Golgi apparatus, Golgi-associated vesicle, cytosol, intracellular	GTP binding, GTPase activity, nucleotide binding		
YDL138W	RGT2	Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p [Source:SGD;Acc:S000002297]	carbohydrate transport, detection of glucose, signal transduction, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	glucose binding, receptor activity, substrate-specific transmembrane transporter activity, transporter activity		
YDL139C	SCM3	Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation [Source:SGD;Acc:S000002298]	G2/M transition of mitotic cell cycle, chromosome segregation, negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process, protein localization to chromosome, centromeric region	condensed nuclear chromosome, centromeric region, cytoplasm, nucleus	molecular_function		
YDL140C	RPO21	RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime [Source:SGD;Acc:S000002299]	transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex, mitochondrion, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding, nucleotidyltransferase activity, transferase activity		
YDL141W	BPL1	Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation [Source:SGD;Acc:S000002300]	protein biotinylation, protein modification process	cytoplasm, nucleus	ATP binding, biotin-[acetyl-CoA-carboxylase] ligase activity, biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity, biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity, biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity, biotin-[pyruvate-carboxylase] ligase activity, catalytic activity, ligase activity, nucleotide binding		
YDL142C	CRD1	Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis [Source:SGD;Acc:S000002301]	cellular ion homeostasis, lipid biosynthetic process, mitochondrial membrane organization, phospholipid biosynthetic process	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion	cardiolipin synthase activity, phosphotransferase activity, for other substituted phosphate groups, transferase activity		
YDL143W	CCT4	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [Source:SGD;Acc:S000002302]	cellular protein metabolic process, protein folding	chaperonin-containing T-complex, cytoplasm	ATP binding, nucleotide binding, unfolded protein binding		
YDL144C	YDL144C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene. [Source:SGD;Acc:S000002303]	biological_process, metabolic process, oxidation-reduction process, pantothenate biosynthetic process	cytoplasm, nucleus	NADP binding, binding, catalytic activity, coenzyme binding, molecular_function, oxidoreductase activity		
YDL145C	COP1	Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway [Source:SGD;Acc:S000002304]	ER to Golgi vesicle-mediated transport, intracellular protein transport, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	COPI coated vesicle membrane, COPI vesicle coat, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, membrane, membrane coat	protein binding, structural molecule activity, ubiquitin binding		
YDL146W	LDB17	Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck [Source:SGD;Acc:S000002305]	endocytosis	actin cortical patch, cellular bud, cellular bud neck, cytoplasm	molecular_function		
YDL147W	RPN5	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p [Source:SGD;Acc:S000002306]	ubiquitin-dependent protein catabolic process	proteasome complex, proteasome regulatory particle, lid subcomplex, proteasome storage granule	molecular_function, protein binding		
YDL148C	NOP14	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA [Source:SGD;Acc:S000002307]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis	90S preribosome, Noc4p-Nop14p complex, mitochondrion, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	snoRNA binding		
YDL149W	ATG9	Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS [Source:SGD;Acc:S000002308]	CVT pathway, autophagic vacuole assembly, autophagy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein homooligomerization, protein transport, transport	cytoplasmic vesicle, cytoplasmic vesicle membrane, integral to membrane, membrane, membrane fraction, mitochondrion, pre-autophagosomal structure, pre-autophagosomal structure membrane	molecular_function		
YDL150W	RPC53	RNA polymerase III subunit C53 [Source:SGD;Acc:S000002309]	tRNA transcription from RNA polymerase III promoter, transcription from RNA polymerase III promoter	DNA-directed RNA polymerase III complex, nucleus	DNA binding, DNA-directed RNA polymerase activity		
YDL151C	BUD30	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay [Source:SGD;Acc:S000002310]					
YDL152W	YDL152W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome [Source:SGD;Acc:S000002311]					
YDL153C	SAS10	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000002312]	cell cycle, endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), gene silencing, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	molecular_function		
YDL154W	MSH5	Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans [Source:SGD;Acc:S000002313]	DNA repair, mismatch repair, reciprocal meiotic recombination, response to DNA damage stimulus	nucleus	ATP binding, DNA binding, mismatched DNA binding, molecular_function, nucleotide binding		
YDL155W	CLB3	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation [Source:SGD;Acc:S000002314]	G2/M transition of mitotic cell cycle, S phase of mitotic cell cycle, cell cycle, cell division, mitosis, positive regulation of spindle pole body separation, regulation of cyclin-dependent protein kinase activity	cytoplasm, nucleus	cyclin-dependent protein kinase regulator activity		
YDL156W	YDL156W	Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000002315]	biological_process	cytoplasm, nucleus	molecular_function, protein binding		
YDL157C	YDL157C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002316]	biological_process	mitochondrion	molecular_function		
YDL158C	YDL158C	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002317]					
YDL159C-B	YDL159C-B	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028612]					
YDL159W	STE7	Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway [Source:SGD;Acc:S000002318]	MAPKKK cascade involved in cell wall biogenesis, MAPKKK cascade involved in conjugation with cellular fusion, activation of MAPK activity involved in conjugation with cellular fusion, invasive growth in response to glucose limitation, protein phosphorylation, pseudohyphal growth, regulation of transposition, RNA-mediated, response to pheromone, signal transduction involved in filamentous growth	cytoplasm, mating projection tip	ATP binding, MAP kinase kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDL159W-A	YDL159W-A	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000007599]	biological_process	cellular_component	molecular_function		
YDL160C	DHH1	Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation [Source:SGD;Acc:S000002319]	cell morphogenesis involved in conjugation with cellular fusion, cytoplasmic mRNA processing body assembly, deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA processing, mRNA transport, regulation of translation, stress granule assembly, transport	cytoplasm, cytoplasmic mRNA processing body, stress granule	ATP binding, ATP-dependent helicase activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding		
YDL160C-A	YDL160C-A	Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF2, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability [Source:SGD;Acc:S000028520]	response to DNA damage stimulus	cellular_component	molecular_function		
YDL161W	ENT1	Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus [Source:SGD;Acc:S000002320]	actin cortical patch assembly, actin filament organization, endocytosis	actin cortical patch, cytoplasm, mating projection tip, membrane	clathrin binding, lipid binding		
YDL162C	YDL162C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly [Source:SGD;Acc:S000002321]					
YDL163W	YDL163W	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase [Source:SGD;Acc:S000002322]					
YDL164C	CDC9	DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination [Source:SGD;Acc:S000002323]	DNA ligation, DNA ligation involved in DNA repair, DNA recombination, DNA repair, DNA replication, base-excision repair, cell cycle, cell division, lagging strand elongation, mitotic cell cycle, nucleotide-excision repair, response to DNA damage stimulus	mitochondrion, nucleus, replication fork	ATP binding, DNA binding, DNA ligase (ATP) activity, DNA ligase activity, ligase activity, metal ion binding, nucleotide binding		
YDL165W	CDC36	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor [Source:SGD;Acc:S000002324]	negative regulation of transcription from RNA polymerase II promoter, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, nuclear-transcribed mRNA poly(A) tail shortening, protein ubiquitination, regulation of cell cycle, regulation of transcription from RNA polymerase II promoter, response to pheromone involved in conjugation with cellular fusion, transcription elongation from RNA polymerase II promoter	CCR4-NOT core complex, cytoplasm, nucleus	ubiquitin-protein ligase activity		
YDL166C	FAP7	Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D [Source:SGD;Acc:S000002325]	cellular response to oxidative stress, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	cytoplasm, nucleus	ATP binding, adenylate kinase activity, kinase activity, nucleoside-triphosphatase activity, nucleotide binding, transferase activity		
YDL167C	NRP1	Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000002326]	biological_process	cytoplasm, intracellular, stress granule	RNA binding, metal ion binding, molecular_function, nucleic acid binding, nucleotide binding, zinc ion binding		
YDL168W	SFA1	Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p [Source:SGD;Acc:S000002327]	amino acid catabolic process to alcohol via Ehrlich pathway, ethanol oxidation, formaldehyde catabolic process, furaldehyde metabolic process, metabolic process, oxidation-reduction process	cytoplasm, mitochondrion	S-(hydroxymethyl)glutathione dehydrogenase activity, alcohol dehydrogenase (NAD) activity, binding, catalytic activity, hydroxymethylfurfural reductase (NADH) activity, metal ion binding, oxidoreductase activity, zinc ion binding		
YDL169C	UGX2	Protein of unknown function, transcript accumulates in response to any combination of stress conditions [Source:SGD;Acc:S000002328]	biological_process	cellular_component	molecular_function		
YDL170W	UGA3	Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus [Source:SGD;Acc:S000002329]	gamma-aminobutyric acid catabolic process, nitrogen utilization, positive regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YDL171C	GLT1	NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source [Source:SGD;Acc:S000002330]	ammonia assimilation cycle, cellular amino acid biosynthetic process, glutamate biosynthetic process, glutamine metabolic process, metabolic process, nitrogen compound metabolic process, oxidation-reduction process	mitochondrion	3 iron, 4 sulfur cluster binding, FMN binding, catalytic activity, flavin adenine dinucleotide binding, glutamate synthase (NADH) activity, glutamate synthase activity, glutamate synthase activity, NADH or NADPH as acceptor, iron ion binding, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor		
YDL172C	YDL172C	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002331]					
YDL173W	PAR32	Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene [Source:SGD;Acc:S000002332]	biological_process	cytoplasm	molecular_function		
YDL174C	DLD1	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane [Source:SGD;Acc:S000002333]	aerobic respiration, cellular carbohydrate metabolic process, oxidation-reduction process	membrane, mitochondrial inner membrane, mitochondrion	D-lactate dehydrogenase (cytochrome) activity, catalytic activity, flavin adenine dinucleotide binding, oxidoreductase activity		
YDL175C	AIR2	Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p [Source:SGD;Acc:S000002334]	ncRNA polyadenylation, nuclear mRNA surveillance of mRNA 3'-end processing, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent snRNA catabolic process, nuclear polyadenylation-dependent snoRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process	TRAMP complex, nucleolus, nucleus	metal ion binding, nucleic acid binding, polynucleotide adenylyltransferase activity, zinc ion binding		
YDL176W	YDL176W	Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene [Source:SGD;Acc:S000002335]	biological_process	cellular_component	molecular_function		
YDL177C	YDL177C	Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene [Source:SGD;Acc:S000002336]	biological_process	cellular_component	molecular_function		
YDL178W	DLD2	D-lactate dehydrogenase, located in the mitochondrial matrix [Source:SGD;Acc:S000002337]	lactate metabolic process, oxidation-reduction process	mitochondrial matrix, mitochondrion	D-lactate dehydrogenase (cytochrome) activity, actin binding, catalytic activity, flavin adenine dinucleotide binding, oxidoreductase activity		
YDL179W	PCL9	Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p [Source:SGD;Acc:S000002338]	cell cycle, cell division, regulation of cell division, regulation of cyclin-dependent protein kinase activity, regulation of establishment or maintenance of cell polarity, regulation of transcription involved in G1/S phase of mitotic cell cycle	cellular bud neck, cyclin-dependent protein kinase holoenzyme complex, incipient cellular bud site	cyclin-dependent protein kinase regulator activity, protein kinase binding		
YDL180W	YDL180W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole [Source:SGD;Acc:S000002339]	biological_process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YDL181W	INH1	Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro [Source:SGD;Acc:S000002340]	negative regulation of ATPase activity, negative regulation of nucleotide metabolic process	mitochondrion	enzyme inhibitor activity		
YDL182W	LYS20	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p [Source:SGD;Acc:S000002341]	carboxylic acid metabolic process, cellular amino acid biosynthetic process, lysine biosynthetic process, lysine biosynthetic process via aminoadipic acid, metabolic process	cytoplasm, mitochondrion, nucleus	catalytic activity, homocitrate synthase activity, transferase activity, transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer		
YDL183C	YDL183C	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene [Source:SGD;Acc:S000002342]	potassium ion transport, proton transport	integral to mitochondrial inner membrane	molecular_function		
YDL184C	RPL41A	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable [Source:SGD;Acc:S000002343]	translation	cytoplasm, cytosolic large ribosomal subunit, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDL185C-A	YDL185C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDL185W; identified by homology with hemiascomycetous yeast species [Source:SGD;Acc:S000007600]					
YDL185W	VMA1	Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease [Source:SGD;Acc:S000002344]	ATP hydrolysis coupled proton transport, ATP metabolic process, ATP synthesis coupled proton transport, cellular protein metabolic process, intein-mediated protein splicing, intron homing, ion transport, proton transport, transport, vacuolar acidification	endomembrane system, fungal-type vacuole membrane, membrane, proton-transporting two-sector ATPase complex, proton-transporting two-sector ATPase complex, catalytic domain, vacuolar membrane, vacuolar proton-transporting V-type ATPase, V1 domain, vacuole	ATP binding, DNA binding, endodeoxyribonuclease activity, endonuclease activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, nuclease activity, nucleotide binding, proton-transporting ATPase activity, rotational mechanism		
YDL186W	YDL186W	Putative protein of unknown function; YDL186W is not an essential gene [Source:SGD;Acc:S000002345]	biological_process	cellular_component	molecular_function		
YDL187C	YDL187C	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002346]					
YDL188C	PPH22	Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis [Source:SGD;Acc:S000002347]	G1/S transition of mitotic cell cycle, actin filament organization, budding cell bud growth, mitotic cell cycle spindle assembly checkpoint, protein dephosphorylation, regulation of translation	condensed nuclear chromosome, centromeric region	hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YDL189W	RBS1	Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain [Source:SGD;Acc:S000002348]	galactose metabolic process	cytoplasm	RNA binding, molecular_function, nucleic acid binding		
YDL190C	UFD2	Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 [Source:SGD;Acc:S000002349]	protein ubiquitination, response to stress, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus, ubiquitin ligase complex	ligase activity, ubiquitin-protein ligase activity, ubiquitin-ubiquitin ligase activity		
YDL191W	RPL35A	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein [Source:SGD;Acc:S000002350]	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, preribosome, large subunit precursor, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDL192W	ARF1	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p [Source:SGD;Acc:S000002351]	ER to Golgi vesicle-mediated transport, Golgi to plasma membrane transport, intra-Golgi vesicle-mediated transport, macroautophagy, protein transport, small GTPase mediated signal transduction, transport, vesicle-mediated transport	Golgi apparatus, Golgi-associated vesicle, cytosol, intracellular	GTP binding, GTPase activity, nucleotide binding		
YDL193W	NUS1	Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY [Source:SGD;Acc:S000002352]	protein glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, lipid particle, membrane, nuclear envelope, nuclear membrane, nucleus	di-trans,poly-cis-decaprenylcistransferase activity, prenyltransferase activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups		
YDL194W	SNF3	Plasma membrane low glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; similar to Rgt2p [Source:SGD;Acc:S000002353]	carbohydrate transport, detection of glucose, fructose transport, glucose transport, mannose transport, negative regulation of meiosis, signal transduction, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	glucose binding, receptor activity, substrate-specific transmembrane transporter activity, transporter activity		
YDL195W	SEC31	Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000002354]	COPII-coated vesicle budding, protein transport, transport, vesicle-mediated transport	COPII vesicle coat, ER to Golgi transport vesicle membrane, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, mating projection tip, membrane	structural molecule activity		
YDL196W	YDL196W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 [Source:SGD;Acc:S000002355]					
YDL197C	ASF2	Anti-silencing protein that causes derepression of silent loci when overexpressed [Source:SGD;Acc:S000002356]	chromatin silencing at silent mating-type cassette	nuclear chromosome, telomeric region, nucleus	molecular_function		
YDL198C	GGC1	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family [Source:SGD;Acc:S000002357]	cellular iron ion homeostasis, guanine nucleotide transport, mitochondrial genome maintenance, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, guanine nucleotide transmembrane transporter activity		
YDL199C	YDL199C	Putative transporter, member of the sugar porter family [Source:SGD;Acc:S000002358]	transmembrane transport, transport	integral to membrane, membrane	substrate-specific transmembrane transporter activity, transporter activity		
YDL200C	MGT1	DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage [Source:SGD;Acc:S000002359]	DNA dealkylation involved in DNA repair, DNA repair, response to DNA damage stimulus	nucleus	DNA binding, catalytic activity, methylated-DNA-[protein]-cysteine S-methyltransferase activity, methyltransferase activity, transferase activity		
YDL201W	TRM8	Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA [Source:SGD;Acc:S000002360]	tRNA methylation, tRNA modification, tRNA processing	nucleus	RNA binding, methyltransferase activity, protein binding, tRNA (guanine-N7-)-methyltransferase activity, tRNA binding, transferase activity		
YDL202W	MRPL11	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000002361]	mitochondrial translation, ribosome biogenesis	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDL203C	ACK1	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria [Source:SGD;Acc:S000002362]	fungal-type cell wall organization, positive regulation of signal transduction	mitochondrion	binding, molecular_function		
YDL204W	RTN2	Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily [Source:SGD;Acc:S000002363]	biological_process	cortical endoplasmic reticulum, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear envelope	molecular_function		
YDL205C	HEM3	Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme [Source:SGD;Acc:S000002364]	heme biosynthetic process, peptidyl-pyrromethane cofactor linkage, porphyrin biosynthetic process, tetrapyrrole biosynthetic process	cytoplasm, nucleus	hydroxymethylbilane synthase activity, transferase activity		
YDL206W	YDL206W	Putative protein of unknown function; YDL206W is not an essential protein [Source:SGD;Acc:S000002365]	biological_process, ion transport, transmembrane transport, transport	cellular_component, integral to membrane, membrane	molecular_function		
YDL207W	GLE1	Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal [Source:SGD;Acc:S000002366]	mRNA export from nucleus, mRNA processing, mRNA transport, poly(A)+ mRNA export from nucleus, protein transport, translational initiation, translational termination, transmembrane transport, transport	membrane, mitochondrion, nuclear membrane, nuclear pore, nucleus	enzyme activator activity, inositol hexakisphosphate binding, translation initiation factor binding		
YDL208W	NHP2	Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing [Source:SGD;Acc:S000002367]	cleavage involved in rRNA processing, rRNA processing, rRNA pseudouridine synthesis, ribosome biogenesis, snRNA pseudouridine synthesis	box H/ACA snoRNP complex, nucleolus, nucleus, ribonucleoprotein complex	RNA binding, snoRNA binding		
YDL209C	CWC2	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 [Source:SGD;Acc:S000002368]	RNA splicing, cell cycle, mRNA processing, nuclear mRNA splicing, via spliceosome	Prp19 complex, U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, nucleus, spliceosomal complex	RNA binding, U6 snRNA binding, first spliceosomal transesterification activity, metal ion binding, nucleic acid binding, nucleotide binding, second spliceosomal transesterification activity, zinc ion binding		
YDL210W	UGA4	Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane [Source:SGD;Acc:S000002369]	amino acid transport, gamma-aminobutyric acid transport, putrescine transport, transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	amino acid transmembrane transporter activity, gamma-aminobutyric acid:hydrogen symporter activity, putrescine transmembrane transporter activity		
YDL211C	YDL211C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole [Source:SGD;Acc:S000002370]	biological_process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YDL212W	SHR3	Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface [Source:SGD;Acc:S000002371]	ER to Golgi vesicle-mediated transport, protein folding, protein transport, transmembrane transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, mating projection tip, membrane	unfolded protein binding		
YDL213C	NOP6	rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes [Source:SGD;Acc:S000002372]	rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis	90S preribosome, nucleolus, nucleus	RNA binding, nucleic acid binding, nucleotide binding, rRNA binding		
YDL214C	PRR2	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000002373]	negative regulation of conjugation with cellular fusion, negative regulation of transcription from RNA polymerase II promoter by pheromones, protein phosphorylation, response to pheromone	nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, receptor signaling protein serine/threonine kinase activity, transferase activity		
YDL215C	GDH2	NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels [Source:SGD;Acc:S000002374]	cellular amino acid metabolic process, glutamate catabolic process to 2-oxoglutarate, metabolic process, nitrogen compound metabolic process, oxidation-reduction process	mitochondrion	binding, catalytic activity, glutamate dehydrogenase activity, oxidoreductase activity		
YDL216C	RRI1	Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling [Source:SGD;Acc:S000002375]	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, cullin deneddylation	cytoplasm, nucleus, signalosome	hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein binding		
YDL217C	TIM22	Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported [Source:SGD;Acc:S000002376]	protein import into mitochondrial inner membrane, protein transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial inner membrane protein insertion complex, mitochondrion	mitochondrion targeting sequence binding, protein channel activity, protein transporter activity		
YDL218W	YDL218W	Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000002377]	biological_process	cytoplasm, integral to membrane, membrane	molecular_function		
YDL219W	DTD1	D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes [Source:SGD;Acc:S000002378]	D-amino acid catabolic process, translation	cytoplasm	D-tyrosyl-tRNA(Tyr) deacylase activity, hydrolase activity, hydrolase activity, acting on ester bonds		
YDL220C	CDC13	Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping [Source:SGD;Acc:S000002379]	cell cycle, cell division, negative regulation of telomerase activity, regulation of telomere maintenance via telomerase, telomere capping, telomere maintenance, telomere maintenance via telomerase	chromosome, telomeric region, nuclear chromosome, telomeric region, nuclear telomere cap complex	DNA binding, single-stranded telomeric DNA binding, telomerase inhibitor activity		
YDL221W	YDL221W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13 [Source:SGD;Acc:S000002380]					
YDL222C	FMP45	Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C [Source:SGD;Acc:S000002381]	ascospore formation, fungal-type cell wall organization, response to stress, sporulation resulting in formation of a cellular spore	cell cortex, integral to membrane, membrane, mitochondrion, plasma membrane, plasma membrane enriched fraction	molecular_function		
YDL223C	HBT1	Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis [Source:SGD;Acc:S000002382]	cell morphogenesis involved in conjugation with cellular fusion, conjugation, regulation of cell shape	cytoplasm, mating projection, plasma membrane enriched fraction	molecular_function		
YDL224C	WHI4	Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division [Source:SGD;Acc:S000002383]	regulation of cell size	cytoplasm	RNA binding, nucleic acid binding, nucleotide binding		
YDL225W	SHS1	One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis [Source:SGD;Acc:S000002384]	cell cycle, cell division, cell morphogenesis, cytokinesis, establishment of cell polarity	cellular bud neck, mating projection tip, membrane, septin complex, septin ring	GTP binding, nucleotide binding, structural constituent of cytoskeleton		
YDL226C	GCS1	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p [Source:SGD;Acc:S000002385]	ER to Golgi vesicle-mediated transport, Golgi to plasma membrane protein transport, actin filament reorganization involved in cell cycle, protein transport, regulation of ARF GTPase activity, retrograde vesicle-mediated transport, Golgi to ER, transport	ER-Golgi intermediate compartment, Golgi apparatus, cytoplasm, cytoskeleton, endosome, mitochondrion, perinuclear region of cytoplasm, trans-Golgi network	ARF GTPase activator activity, GTPase activator activity, actin binding, metal ion binding, zinc ion binding		
YDL227C	HO	Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p [Source:SGD;Acc:S000002386]	gene conversion at mating-type locus, DNA double-strand break formation, intein-mediated protein splicing, mating type switching	nucleus	DNA binding, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity		
YDL228C	YDL228C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1 [Source:SGD;Acc:S000002387]					
YDL229W	SSB1	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p [Source:SGD;Acc:S000002388]	'de novo' cotranslational protein folding, cellular response to glucose starvation, rRNA processing, regulation of translational fidelity, response to stress, ribosomal subunit export from nucleus, translation, translational termination	cytoplasm, plasma membrane enriched fraction, polysome, soluble fraction	ATP binding, ATPase activity, calmodulin binding, nucleotide binding, unfolded protein binding		
YDL230W	PTP1	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria [Source:SGD;Acc:S000002389]	dephosphorylation, protein dephosphorylation	cytoplasm, mitochondrion	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity		
YDL231C	BRE4	Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport [Source:SGD;Acc:S000002390]	endocytosis, protein transport, transport	integral to membrane, membrane	molecular_function		
YDL232W	OST4	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex [Source:SGD;Acc:S000002391]	protein N-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity, protein binding, bridging, transferase activity		
YDL233W	YDL233W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene [Source:SGD;Acc:S000002392]	biological_process	cytoplasm, nucleus	molecular_function		
YDL234C	GYP7	GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking [Source:SGD;Acc:S000002393]	regulation of Rab GTPase activity, regulation of vacuole fusion, non-autophagic, vesicle-mediated transport	cytoplasm, intracellular	GTPase activator activity, Rab GTPase activator activity		
YDL235C	YPD1	Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus [Source:SGD;Acc:S000002394]	osmosensory signaling pathway via two-component system, two-component signal transduction system (phosphorelay)	cytoplasm, nucleus	protein histidine kinase binding, signal transducer activity, transferase activity, transferring phosphorus-containing groups		
YDL236W	PHO13	Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity [Source:SGD;Acc:S000002395]	metabolic process, protein dephosphorylation	cytoplasm, nucleus	4-nitrophenylphosphatase activity, alkaline phosphatase activity, catalytic activity, hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity		
YDL237W	AIM6	Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene [Source:SGD;Acc:S000002396]	biological_process	cellular_component	molecular_function		
YDL238C	GUD1	Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures [Source:SGD;Acc:S000002397]	guanine metabolic process	cytoplasm	guanine deaminase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, metal ion binding, zinc ion binding		
YDL239C	ADY3	Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000002398]	ascospore wall assembly, cell cycle, cell division, meiosis, mitochondrion inheritance, sporulation resulting in formation of a cellular spore	cytoplasm, cytoskeleton, membrane, nucleus, prospore membrane, spindle pole body	molecular_function		
YDL240C-A	YDL240C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000007601]					
YDL240W	LRG1	Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis [Source:SGD;Acc:S000002399]	fungal-type cell wall biogenesis, signal transduction, small GTPase mediated signal transduction, sporulation resulting in formation of a cellular spore	cellular bud, cellular bud neck, cytoplasm, intracellular, mitochondrion	GTPase activator activity, Rho GTPase activator activity, metal ion binding, zinc ion binding		
YDL241W	YDL241W	Putative protein of unknown function; YDL241W is not an essential gene [Source:SGD;Acc:S000002400]	biological_process	cellular_component	molecular_function		
YDL242W	YDL242W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002401]					
YDL243C	AAD4	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response; expression induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000002402]	cellular aldehyde metabolic process, oxidation-reduction process, response to stress	cellular_component	aryl-alcohol dehydrogenase activity, oxidoreductase activity		
YDL244W	THI13	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 [Source:SGD;Acc:S000002403]	thiamine biosynthetic process	cellular_component	molecular_function		
YDL245C	HXT15	Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose [Source:SGD;Acc:S000002404]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	fructose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YDL246C	SOR2	Protein of unknown function; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase; computational analysis of large-scale protein-protein interaction data also suggests a role in fructose or mannose metabolism [Source:SGD;Acc:S000002405]	hexose metabolic process, metabolic process, oxidation-reduction process	cellular_component	L-iditol 2-dehydrogenase activity, binding, catalytic activity, metal ion binding, oxidoreductase activity, zinc ion binding		
YDL247W	MPH2	Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication [Source:SGD;Acc:S000002406]	carbohydrate transport, maltose metabolic process, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	carbohydrate transmembrane transporter activity, maltose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YDL247W-A	YDL247W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000007602]					
YDL248W	COS7	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002407]	biological_process	integral to membrane, membrane, mitochondrion	receptor activity		
YDR001C	NTH1	Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p [Source:SGD;Acc:S000002408]	metabolic process, response to stress, trehalose catabolic process, trehalose metabolic process	cytoplasm, cytosol	alpha,alpha-trehalase activity, calcium ion binding, catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds		
YDR002W	YRB1	Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 [Source:SGD;Acc:S000002409]	G1/S transition of mitotic cell cycle, RNA export from nucleus, intracellular transport, protein import into nucleus, protein transport, transport, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus	GTPase activator activity, Ran GTPase binding		
YDR003W	RCR2	Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p [Source:SGD;Acc:S000002410]	vesicle-mediated transport	cytoplasm, fungal-type vacuole, integral to membrane, membrane, vesicle	molecular_function		
YDR003W-A	YDR003W-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028819]	biological_process	cellular_component	molecular_function		
YDR004W	RAD57	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p [Source:SGD;Acc:S000002411]	DNA metabolic process, DNA recombinase assembly, DNA repair, heteroduplex formation, meiosis, meiotic DNA recombinase assembly, response to DNA damage stimulus, telomere maintenance via recombination	Rhp55-Rhp57 complex, nucleus	ATP binding, DNA binding, DNA-dependent ATPase activity, nucleoside-triphosphatase activity, nucleotide binding, protein heterodimerization activity		
YDR005C	MAF1	Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB [Source:SGD;Acc:S000002412]	negative regulation of transcription from RNA polymerase III promoter	cytoplasm, nucleus			
YDR006C	SOK1	Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 [Source:SGD;Acc:S000002413]	cAMP-mediated signaling	nucleus	molecular_function		
YDR007W	TRP1	Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) [Source:SGD;Acc:S000002414]	aromatic amino acid family biosynthetic process, cellular amino acid biosynthetic process, metabolic process, tryptophan biosynthetic process, tryptophan metabolic process	cytoplasm	catalytic activity, isomerase activity, phosphoribosylanthranilate isomerase activity		
YDR008C	YDR008C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002415]					
YDR009W	GAL3	Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity [Source:SGD;Acc:S000002416]	carbohydrate metabolic process, carbohydrate phosphorylation, galactose metabolic process, metabolic process, phosphorylation, positive regulation of transcription by galactose	cytoplasm, nucleus	ATP binding, galactokinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor		
YDR010C	YDR010C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002417]					
YDR011W	SNQ2	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species [Source:SGD;Acc:S000002418]	response to drug, response to singlet oxygen, transport	integral to membrane, membrane, membrane fraction, mitochondrion, plasma membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding, xenobiotic-transporting ATPase activity		
YDR012W	RPL4B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins [Source:SGD;Acc:S000002419]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YDR013W	PSF1	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery [Source:SGD;Acc:S000002420]	DNA replication, DNA-dependent DNA replication, cell cycle, double-strand break repair via break-induced replication	DNA replication preinitiation complex, GINS complex, nucleus, replication fork protection complex	molecular_function		
YDR014W	RAD61	Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin [Source:SGD;Acc:S000002421]	mitotic sister chromatid cohesion	nuclear cohesin complex, nucleus	molecular_function		
YDR014W-A	HED1	Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase [Source:SGD;Acc:S000113613]	DNA recombination, DNA repair, meiosis, negative regulation of mitotic recombination, response to DNA damage stimulus	chromosome, condensed nuclear chromosome, nucleus	molecular_function		
YDR015C	YDR015C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A [Source:SGD;Acc:S000002422]					
YDR016C	DAD1	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000002423]	cell cycle, cell division, chromosome segregation, mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization	DASH complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle	microtubule binding, structural constituent of cytoskeleton		
YDR017C	KCS1	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance [Source:SGD;Acc:S000002424]	inositol phosphate biosynthetic process	cytoplasm	ATP binding, inositol 1,3,4,5,6-pentakisphosphate kinase activity, inositol heptakisphosphate 5-kinase activity, inositol heptakisphosphate kinase activity, inositol hexakisphosphate kinase activity, inositol trisphosphate 3-kinase activity, kinase activity, nucleotide binding, transferase activity		
YDR018C	YDR018C	Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase [Source:SGD;Acc:S000002425]	metabolic process, phospholipid biosynthetic process	cellular_component, integral to membrane, membrane	acyltransferase activity, transferase activity		
YDR019C	GCV1	T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm [Source:SGD;Acc:S000002426]	glycine catabolic process, glycine metabolic process, one-carbon metabolic process	cytoplasm, glycine cleavage complex, mitochondrion	aminomethyltransferase activity, glycine dehydrogenase (decarboxylating) activity, transaminase activity, transferase activity		
YDR020C	DAS2	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases [Source:SGD;Acc:S000002427]	biological_process, metabolic process	cytoplasm, nucleus	ATP binding, kinase activity, molecular_function, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity, uridine kinase activity		
YDR021W	FAL1	Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases [Source:SGD;Acc:S000002428]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YDR022C	CIS1	Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion [Source:SGD;Acc:S000002429]	autophagy, chromosome segregation, karyogamy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein transport, transport	cytoplasm, cytoskeleton, microtubule, pre-autophagosomal structure	molecular_function		
YDR023W	SES1	Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p [Source:SGD;Acc:S000002430]	seryl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, serine-tRNA ligase activity		
YDR024W	FYV1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin [Source:SGD;Acc:S000002431]					
YDR025W	RPS11A	Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins [Source:SGD;Acc:S000002432]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit assembly, translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YDR026C	YDR026C	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p [Source:SGD;Acc:S000002433]	biological_process	nucleolus, nucleus, ribosome	DNA binding, protein binding		
YDR027C	VPS54	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000002434]	Golgi to vacuole transport, ascospore wall assembly, protein transport, retrograde transport, endosome to Golgi, transport	GARP complex, Golgi apparatus, endosome, endosome membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YDR028C	REG1	Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes [Source:SGD;Acc:S000002435]	cellular response to glucose starvation, glycogen metabolic process, negative regulation of transcription from RNA polymerase II promoter, regulation of carbohydrate metabolic process, vacuolar protein catabolic process	cytoplasm, nucleus, protein phosphatase type 1 complex	protein phosphatase type 1 regulator activity		
YDR029W	YDR029W	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002436]					
YDR030C	RAD28	Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair [Source:SGD;Acc:S000002437]	DNA repair, response to DNA damage stimulus	nucleus	molecular_function, protein binding		
YDR031W	MIC14	Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000002438]	aerobic respiration	cytoplasm, mitochondrial intermembrane space, mitochondrion, nucleus	molecular_function		
YDR032C	PST2	Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002439]	biological_process	cytoplasm, extracellular region, membrane raft, mitochondrion, plasma membrane enriched fraction	FMN binding, molecular_function, oxidoreductase activity		
YDR033W	MRH1	Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p [Source:SGD;Acc:S000002440]	biological_process, ion transport	cellular bud, integral to membrane, membrane, membrane fraction, mitochondrion, plasma membrane, plasma membrane enriched fraction	ion channel activity, molecular_function		
YDR034C	LYS14	Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer [Source:SGD;Acc:S000002441]	cellular amino acid biosynthetic process, lysine biosynthetic process, lysine biosynthetic process via aminoadipic acid, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YDR034C-A	YDR034C-A	Putative protein of unknown function; contained within the solo Ty1 LTR element YDRWdelta7 [Source:SGD;Acc:S000007233]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YDR034C-C	YDR034C-C	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007344]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YDR034C-D	YDR034C-D	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007345]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YDR034W-B	YDR034W-B	Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000007234]	biological_process	cell cortex, cellular_component, cytoplasm	molecular_function		
YDR035W	ARO3	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan [Source:SGD;Acc:S000002442]	aromatic amino acid family biosynthetic process, biosynthetic process, cellular amino acid biosynthetic process, metabolic process, response to stress	cytoplasm, mitochondrion, nucleus	3-deoxy-7-phosphoheptulonate synthase activity, catalytic activity, transferase activity		
YDR036C	EHD3	3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis [Source:SGD;Acc:S000002443]	biological_process, branched chain family amino acid catabolic process, metabolic process	mitochondrion	3-hydroxyisobutyryl-CoA hydrolase activity, catalytic activity, hydrolase activity		
YDR037W	KRS1	Lysyl-tRNA synthetase [Source:SGD;Acc:S000002444]	lysyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, lysine-tRNA ligase activity, nucleic acid binding, nucleotide binding		
YDR038C	ENA5	Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family [Source:SGD;Acc:S000002445]	ATP biosynthetic process, cation transport, ion transport, metabolic process, sodium ion transport, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, plasma membrane, plasma membrane enriched fraction	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, nucleotide binding, sodium-exporting ATPase activity, phosphorylative mechanism		
YDR039C	ENA2	P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux [Source:SGD;Acc:S000002446]	ATP biosynthetic process, cation transport, ion transport, metabolic process, potassium ion transport, sodium ion transport, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, mitochondrion, plasma membrane	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, nucleotide binding, potassium-transporting ATPase activity, sodium-exporting ATPase activity, phosphorylative mechanism		
YDR040C	ENA1	P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance [Source:SGD;Acc:S000002447]	ATP biosynthetic process, cation transport, cellular response to glucose starvation, hyperosmotic response, ion transport, metabolic process, potassium ion transport, response to pH, response to salt stress, sodium ion transport, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, plasma membrane, plasma membrane enriched fraction	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, nucleotide binding, potassium-transporting ATPase activity, sodium-exporting ATPase activity, phosphorylative mechanism		
YDR041W	RSM10	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins [Source:SGD;Acc:S000002448]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome, small ribosomal subunit	structural constituent of ribosome		
YDR042C	YDR042C	Putative protein of unknown function; expression is increased in ssu72-ts69 mutant [Source:SGD;Acc:S000002449]	biological_process	cellular_component	molecular_function		
YDR043C	NRG1	Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response [Source:SGD;Acc:S000002450]	biofilm formation, glucose metabolic process, invasive growth in response to glucose limitation, pseudohyphal growth, regulation of transcription from RNA polymerase II promoter, response to pH	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YDR044W	HEM13	Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) [Source:SGD;Acc:S000002451]	heme biosynthetic process, oxidation-reduction process, porphyrin biosynthetic process	cytoplasm, cytosol	coproporphyrinogen oxidase activity, oxidoreductase activity		
YDR045C	RPC11	RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS [Source:SGD;Acc:S000002452]	tRNA transcription from RNA polymerase III promoter, termination of RNA polymerase III transcription	DNA-directed RNA polymerase III complex, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding, nucleic acid binding, zinc ion binding		
YDR046C	BAP3	Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine [Source:SGD;Acc:S000002453]	amino acid transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrion, plasma membrane	amino acid transmembrane transporter activity		
YDR047W	HEM12	Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda [Source:SGD;Acc:S000002454]	heme biosynthetic process, porphyrin biosynthetic process	cytoplasm, nucleus	carboxy-lyase activity, lyase activity, uroporphyrinogen decarboxylase activity		
YDR048C	YDR048C	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002455]					
YDR049W	VMS1	Zinc finger protein, forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and human [Source:SGD;Acc:S000002456]	mitochondria-associated protein catabolic process	cytoplasm, cytosol, intracellular, mitochondrion	metal ion binding, molecular_function, zinc ion binding		
YDR050C	TPI1	Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region [Source:SGD;Acc:S000002457]	fatty acid biosynthetic process, gluconeogenesis, glycolysis, lipid biosynthetic process, metabolic process, pentose-phosphate shunt	cytoplasm, mitochondrion, plasma membrane enriched fraction	catalytic activity, isomerase activity, triose-phosphate isomerase activity		
YDR051C	DET1	Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel [Source:SGD;Acc:S000002458]	dephosphorylation, intracellular sterol transport, lipid transport, metabolic process, transport	cytoplasm, nucleus	acid phosphatase activity, catalytic activity, isomerase activity, phosphoglycerate mutase activity		
YDR052C	DBF4	Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated [Source:SGD;Acc:S000002459]	DNA replication, DNA-dependent DNA replication initiation, cell cycle, cell division, chromosome segregation, meiosis, mitosis, negative regulation of exit from mitosis, positive regulation of protein kinase activity	Dbf4-dependent protein kinase complex	DNA binding, DNA replication origin binding, metal ion binding, nucleic acid binding, protein serine/threonine kinase activator activity, zinc ion binding		
YDR053W	YDR053W	Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex [Source:SGD;Acc:S000002460]					
YDR054C	CDC34	Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation [Source:SGD;Acc:S000002461]	DNA replication, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, post-translational protein modification, protein autoubiquitination, protein polyubiquitination, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, regulation of protein metabolic process	SCF ubiquitin ligase complex, cytoplasm, nucleus	ATP binding, acid-amino acid ligase activity, ligase activity, nucleotide binding, protein homodimerization activity, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YDR055W	PST1	Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 [Source:SGD;Acc:S000002462]	fungal-type cell wall organization	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane, plasma membrane	molecular_function		
YDR056C	YDR056C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein [Source:SGD;Acc:S000002463]	biological_process	endoplasmic reticulum, membrane fraction	molecular_function		
YDR057W	YOS9	ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family [Source:SGD;Acc:S000002464]	ER-associated protein catabolic process	Hrd1p ubiquitin ligase ERAD-L complex, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, luminal surveillance complex, membrane	oligosaccharide binding, sugar binding		
YDR058C	TGL2	Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli [Source:SGD;Acc:S000002465]	lipid catabolic process, triglyceride catabolic process	mitochondrion	hydrolase activity, triglyceride lipase activity		
YDR059C	UBC5	Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible [Source:SGD;Acc:S000002466]	post-translational protein modification, protein polyubiquitination, regulation of protein metabolic process, response to stress	proteasome complex	ATP binding, acid-amino acid ligase activity, ligase activity, nucleotide binding, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YDR060W	MAK21	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein [Source:SGD;Acc:S000002467]	ribosomal large subunit assembly, ribosome biogenesis	Noc1p-Noc2p complex, nucleolus, nucleus	binding, molecular_function		
YDR061W	YDR061W	Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance [Source:SGD;Acc:S000002468]	biological_process, transport	mitochondrion	ATP binding, ATPase activity, molecular_function, nucleoside-triphosphatase activity, nucleotide binding		
YDR062W	LCB2	Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine [Source:SGD;Acc:S000002469]	biosynthetic process, metabolic process, sphingolipid biosynthetic process	SPOTS complex, cytoplasm, endoplasmic reticulum, integral to membrane, membrane, membrane fraction, microsome, serine C-palmitoyltransferase complex	acyltransferase activity, catalytic activity, pyridoxal phosphate binding, serine C-palmitoyltransferase activity, transferase activity, transferase activity, transferring nitrogenous groups		
YDR063W	AIM7	Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss [Source:SGD;Acc:S000002470]	actin filament debranching, negative regulation of Arp2/3 complex-mediated actin nucleation	actin cortical patch, cytoplasm, intracellular, nucleus	actin binding, growth factor activity, molecular_function		
YDR064W	RPS13	Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins [Source:SGD;Acc:S000002471]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	SSU rRNA binding, structural constituent of ribosome		
YDR065W	RRG1	Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002472]	mitochondrial genome maintenance, vacuolar acidification	mitochondrion	molecular_function		
YDR066C	RTR2	Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene [Source:SGD;Acc:S000002473]	biological_process	cytoplasm, nucleus	hydrolase activity, metal ion binding, molecular_function, phosphoprotein phosphatase activity		
YDR067C	OCA6	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT [Source:SGD;Acc:S000002474]	biological_process	cytoplasm	hydrolase activity, molecular_function, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity		
YDR068W	DOS2	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000002475]	biological_process	cytoplasm	molecular_function		
YDR069C	DOA4	Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole [Source:SGD;Acc:S000002476]	endocytosis, free ubiquitin chain depolymerization, protein deubiquitination, regulation of DNA replication, ubiquitin homeostasis, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytoplasm, endosome, late endosome membrane, membrane, membrane fraction, mitochondrion, proteasome complex	cysteine-type peptidase activity, endopeptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YDR070C	FMP16	Putative protein of unknown function; proposed to be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002477]	biological_process	mitochondrion	molecular_function		
YDR071C	PAA1	Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication [Source:SGD;Acc:S000002478]	chromatin organization, metabolic process	cytoplasm	N-acetyltransferase activity, acyltransferase activity, aralkylamine N-acetyltransferase activity, diamine N-acetyltransferase activity, transferase activity		
YDR072C	IPT1	Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid;, can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin [Source:SGD;Acc:S000002479]	mannosyl diphosphorylinositol ceramide metabolic process, sphingolipid biosynthetic process	integral to membrane, membrane, membrane fraction	catalytic activity, transferase activity, transferase activity, transferring phosphorus-containing groups		
YDR073W	SNF11	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p [Source:SGD;Acc:S000002480]	chromatin remodeling, nucleosome mobilization	SWI/SNF complex, nucleus			
YDR074W	TPS2	Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway [Source:SGD;Acc:S000002481]	metabolic process, response to stress, trehalose biosynthetic process	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming), cytoplasm, mitochondrion	catalytic activity, hydrolase activity, trehalose-phosphatase activity		
YDR075W	PPH3	Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p [Source:SGD;Acc:S000002482]	nitrogen compound metabolic process, protein dephosphorylation, response to drug	cytoplasm, nucleus	hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YDR076W	RAD55	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p [Source:SGD;Acc:S000002483]	DNA metabolic process, DNA recombinase assembly, DNA repair, heteroduplex formation, meiotic DNA recombinase assembly, response to DNA damage stimulus	Rhp55-Rhp57 complex, nucleus	ATP binding, DNA binding, DNA-dependent ATPase activity, nucleotide binding, protein heterodimerization activity		
YDR077W	SED1	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites [Source:SGD;Acc:S000002484]	fungal-type cell wall organization, mitochondrial genome maintenance	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane, mitochondrion, ribosome	structural constituent of cell wall		
YDR078C	SHU2	Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p [Source:SGD;Acc:S000002485]	recombinational repair	cellular_component	molecular_function		
YDR079C-A	TFB5	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair [Source:SGD;Acc:S000007603]	DNA repair, nucleotide-excision repair, phosphorylation of RNA polymerase II C-terminal domain, response to DNA damage stimulus	core TFIIH complex, holo TFIIH complex, nucleus	DNA binding		
YDR079W	PET100	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme [Source:SGD;Acc:S000002486]	aerobic respiration, mitochondrial respiratory chain complex IV assembly	integral to membrane, integral to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion	unfolded protein binding		
YDR080W	VPS41	Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport [Source:SGD;Acc:S000002487]	intracellular protein transport, piecemeal microautophagy of nucleus, protein transport, regulation of SNARE complex assembly, regulation of vacuole fusion, non-autophagic, transport, vacuolar protein processing, vacuole fusion, non-autophagic, vacuole organization, vesicle-mediated transport	HOPS complex, endosome, fungal-type vacuole membrane, vacuole	Rab guanyl-nucleotide exchange factor activity, binding, phosphatidylinositol binding, protein binding		
YDR081C	PDC2	Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes [Source:SGD;Acc:S000002488]	glucose catabolic process to ethanol, regulation of thiamine biosynthetic process	nucleus	DNA binding, nucleic acid binding, protein binding		
YDR082W	STN1	Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping [Source:SGD;Acc:S000002489]	negative regulation of telomere maintenance via telomerase, telomere capping	chromosome, telomeric region, nuclear telomere cap complex	single-stranded telomeric DNA binding		
YDR083W	RRP8	Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation [Source:SGD;Acc:S000002490]	rRNA processing	chromosome, telomeric region, nucleolus, nucleus	methyltransferase activity, transferase activity		
YDR084C	TVP23	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000002491]	vesicle-mediated transport	Golgi apparatus, Golgi membrane, cytoplasm, integral to Golgi membrane, integral to membrane, membrane	molecular_function		
YDR085C	AFR1	Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p [Source:SGD;Acc:S000002492]	cell morphogenesis involved in conjugation, cell morphogenesis involved in conjugation with cellular fusion, pheromone-dependent signal transduction involved in conjugation with cellular fusion, regulation of G-protein coupled receptor protein signaling pathway	mating projection base	receptor signaling protein activity		
YDR086C	SSS1	Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p [Source:SGD;Acc:S000002493]	SRP-dependent cotranslational protein targeting to membrane, translocation, intracellular protein transport, posttranslational protein targeting to membrane, translocation, protein targeting, protein transport, transmembrane transport, transport	Sec61 translocon complex, Ssh1 translocon complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity, structural molecule activity		
YDR087C	RRP1	Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles [Source:SGD;Acc:S000002494]	rRNA processing	nucleolus, nucleus, preribosome, large subunit precursor, preribosome, small subunit precursor	molecular_function		
YDR088C	SLU7	RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain [Source:SGD;Acc:S000002495]	RNA splicing, generation of catalytic spliceosome for second transesterification step, mRNA processing	nucleus, spliceosomal complex	metal ion binding, nucleic acid binding, second spliceosomal transesterification activity, zinc ion binding		
YDR089W	YDR089W	Protein of unknown function; deletion confers resistance to Nickel [Source:SGD;Acc:S000002496]	cellular membrane organization	membrane	molecular_function		
YDR090C	YDR090C	Putative protein of unknown function [Source:SGD;Acc:S000002497]	biological_process	integral to membrane, membrane, plasma membrane	molecular_function		
YDR091C	RLI1	Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase [Source:SGD;Acc:S000002498]	rRNA processing, ribosomal large subunit biogenesis, ribosomal subunit export from nucleus, ribosome biogenesis, translation, translational initiation, translational termination, transport	cytoplasm, cytosolic ribosome, nucleus	ATP binding, ATPase activity, electron carrier activity, iron ion binding, iron-sulfur cluster binding, nucleoside-triphosphatase activity, nucleotide binding, translation initiation factor activity		
YDR092W	UBC13	Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus [Source:SGD;Acc:S000002499]	free ubiquitin chain polymerization, post-translational protein modification, postreplication repair, protein monoubiquitination, protein polyubiquitination, regulation of protein metabolic process	cytoplasm, nucleus, ubiquitin conjugating enzyme complex	ATP binding, acid-amino acid ligase activity, ligase activity, nucleotide binding, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YDR093W	DNF2	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase [Source:SGD;Acc:S000002500]	ATP biosynthetic process, endocytosis, establishment or maintenance of cell polarity, intracellular protein transport, metabolic process, phospholipid translocation, phospholipid transport, protein transport, transport	integral to membrane, membrane, membrane fraction, plasma membrane	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, magnesium ion binding, nucleotide binding, phospholipid-translocating ATPase activity		
YDR094W	YDR094W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 [Source:SGD;Acc:S000002501]					
YDR095C	YDR095C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002502]					
YDR096W	GIS1	JmjC domain-containing histone demethylase; transcription factor involved in expression of genes during nutrient limitation and in negative regulation of DPP1 and PHR1; activity is modulated by limited proteasome-mediated proteolysis [Source:SGD;Acc:S000002503]	ascospore wall assembly, histone demethylation, phospholipid metabolic process, positive regulation of transcription from RNA polymerase II promoter	intracellular, mitochondrion, nucleus	DNA binding, histone demethylase activity (H3-K36 specific), metal ion binding, nucleic acid binding, protein binding, sequence-specific DNA binding, zinc ion binding		
YDR097C	MSH6	Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000002504]	DNA repair, meiotic mismatch repair, mismatch repair, response to DNA damage stimulus	MutSalpha complex, nucleus	ATP binding, ATPase activity, DNA binding, four-way junction DNA binding, guanine/thymine mispair binding, mismatched DNA binding, nucleotide binding, single base insertion or deletion binding		
YDR098C	GRX3	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage [Source:SGD;Acc:S000002505]	cell redox homeostasis, cellular iron ion homeostasis, cellular response to oxidative stress	cytosol, nucleus	2 iron, 2 sulfur cluster binding, disulfide oxidoreductase activity, electron carrier activity, iron-sulfur cluster binding, metal ion binding, protein disulfide oxidoreductase activity		
YDR098C-A	YDR098C-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007390]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YDR098C-B	YDR098C-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007391]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YDR099W	BMH2	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling [Source:SGD;Acc:S000002506]	DNA damage checkpoint, DNA-dependent DNA replication initiation, Ras protein signal transduction, ascospore formation, fungal-type cell wall chitin biosynthetic process, glycogen metabolic process, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, pre-replicative complex assembly, pseudohyphal growth, signal transduction involved in filamentous growth	cytoplasm, nucleus, plasma membrane enriched fraction	DNA replication origin binding, phosphoserine binding, protein domain specific binding		
YDR100W	TVP15	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p [Source:SGD;Acc:S000002507]	vesicle-mediated transport	COPI-coated vesicle, Golgi apparatus, Golgi membrane, integral to Golgi membrane, integral to membrane, membrane	molecular_function		
YDR101C	ARX1	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex [Source:SGD;Acc:S000002508]	cellular process, ribosomal large subunit biogenesis	cytoplasm, cytosolic large ribosomal subunit, nucleoplasm, nucleus	hydrolase activity, metal ion binding, metallopeptidase activity, molecular_function, peptidase activity		
YDR102C	YDR102C	Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index [Source:SGD;Acc:S000002509]					
YDR103W	STE5	Pheromone-response scaffold protein that controls the mating decision; binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p; allosteric activator of Fus3p [Source:SGD;Acc:S000002510]	invasive growth in response to glucose limitation, negative regulation of MAPKKK cascade, pheromone-dependent signal transduction involved in conjugation with cellular fusion, positive regulation of protein phosphorylation, regulation of transposition, RNA-mediated, response to pheromone	cytoplasm, mating projection tip, nucleus, plasma membrane	MAP-kinase scaffold activity, phospholipid binding, protein binding, zinc ion binding		
YDR104C	SPO71	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis [Source:SGD;Acc:S000002511]	ascospore wall assembly, sporulation resulting in formation of a cellular spore	ascospore wall	molecular_function, protein binding		
YDR105C	TMS1	Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance [Source:SGD;Acc:S000002512]	biological_process	integral to membrane, membrane, vacuolar membrane	molecular_function		
YDR106W	ARP10	Component of the dynactin complex, localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex [Source:SGD;Acc:S000002513]	mitosis	cytoplasm, cytoskeleton, dynactin complex, dynein complex, microtubule	motor activity, structural constituent of cytoskeleton		
YDR107C	TMN2	Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments [Source:SGD;Acc:S000002514]	cellular copper ion homeostasis, invasive growth in response to glucose limitation, pseudohyphal growth, vacuolar transport	fungal-type vacuole membrane, integral to membrane, membrane	molecular_function		
YDR108W	TRS85	Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role [Source:SGD;Acc:S000002515]	CVT pathway, ER to Golgi vesicle-mediated transport, macroautophagy, meiosis, peroxisome degradation, piecemeal microautophagy of nucleus, protein localization to pre-autophagosomal structure, sporulation resulting in formation of a cellular spore, transport, vesicle organization, vesicle-mediated transport	Golgi apparatus, TRAPP complex, endoplasmic reticulum, pre-autophagosomal structure	molecular_function		
YDR109C	YDR109C	Putative kinase [Source:SGD;Acc:S000002516]	biological_process, carbohydrate metabolic process	cellular_component	kinase activity, molecular_function, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YDR110W	FOB1	Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases [Source:SGD;Acc:S000002517]	DNA recombination, chromatin silencing at rDNA, extrachromosomal circular DNA accumulation involved in cell aging, negative regulation of DNA replication, protein localization to nucleolar rDNA repeats, rDNA condensation, replicative cell aging	nucleolus	rDNA spacer replication fork barrier binding		
YDR111C	ALT2	Putative alanine transaminase (glutamic pyruvic transaminase) [Source:SGD;Acc:S000002518]	biological_process, biosynthetic process	cytoplasm, nucleus	1-aminocyclopropane-1-carboxylate synthase activity, L-alanine:2-oxoglutarate aminotransferase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity, transferase activity, transferring nitrogenous groups		
YDR112W	IRC2	Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000002519]					
YDR113C	PDS1	Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation [Source:SGD;Acc:S000002520]	DNA metabolic process, cell cycle, cell division, chromosome organization, chromosome segregation, meiosis I, mitosis, mitotic sister chromatid segregation, protein localization, recombinational repair	cytoplasm, nucleus, spindle	enzyme binding		
YDR114C	YDR114C	Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium [Source:SGD;Acc:S000002521]	biological_process	cellular_component	molecular_function		
YDR115W	YDR115W	Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins [Source:SGD;Acc:S000002522]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDR116C	MRPL1	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000002523]	RNA processing, mitochondrial translation, translation	intracellular, large ribosomal subunit, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YDR117C	TMA64	Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity [Source:SGD;Acc:S000002524]	biological_process, translational initiation	ribosome	RNA binding, protein binding, translation initiation factor activity		
YDR118W	APC4	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000002525]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, cyclin catabolic process, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, protein ubiquitination	anaphase-promoting complex, cytoplasm, nucleus	ubiquitin-protein ligase activity		
YDR118W-A	YDR118W-A	Dubious open reading frame; identified using a combination of expression profiling and mass spectrometry [Source:SGD;Acc:S000028820]					
YDR119W	VBA4	Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene [Source:SGD;Acc:S000002526]	amino acid transport, biological_process, transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YDR119W-A	YDR119W-A	Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase) [Source:SGD;Acc:S000113555]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YDR120C	TRM1	tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments [Source:SGD;Acc:S000002527]	tRNA methylation, tRNA processing	cytoplasm, mitochondrion, nuclear envelope, nuclear inner membrane, nucleus	RNA binding, methyltransferase activity, tRNA (guanine-N2-)-methyltransferase activity, transferase activity		
YDR121W	DPB4	Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing [Source:SGD;Acc:S000002528]	DNA replication, chromatin silencing at telomere, lagging strand elongation, leading strand elongation	chromatin accessibility complex, epsilon DNA polymerase complex, nucleus	DNA binding, DNA-directed DNA polymerase activity, double-stranded DNA binding, nucleotidyltransferase activity, transferase activity		
YDR122W	KIN1	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p [Source:SGD;Acc:S000002529]	exocytosis, protein autophosphorylation, protein phosphorylation	cytoplasm, internal side of plasma membrane, membrane, plasma membrane	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDR123C	INO2	Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion [Source:SGD;Acc:S000002530]	phospholipid biosynthetic process, positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding		
YDR124W	YDR124W	Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor [Source:SGD;Acc:S000002531]	biological_process	cellular_component	molecular_function		
YDR125C	ECM18	Protein of unknown function, similar to Rlp24p [Source:SGD;Acc:S000002532]	cellular cell wall organization, fungal-type cell wall organization	mitochondrion	acyltransferase activity, molecular_function, transferase activity		
YDR126W	SWF1	Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion [Source:SGD;Acc:S000002533]	ascospore wall assembly, cortical actin cytoskeleton organization, establishment of cell polarity, protein palmitoylation, regulation of exocytosis, vacuole fusion, non-autophagic	actin cortical patch, actin filament bundle, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear outer membrane-endoplasmic reticulum membrane network	acyltransferase activity, metal ion binding, protein-cysteine S-palmitoleyltransferase activity, transferase activity, zinc ion binding		
YDR127W	ARO1	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids [Source:SGD;Acc:S000002534]	aromatic amino acid family biosynthetic process, cellular amino acid biosynthetic process, metabolic process, oxidation-reduction process	cytoplasm	3-dehydroquinate dehydratase activity, 3-dehydroquinate synthase activity, 3-phosphoshikimate 1-carboxyvinyltransferase activity, ATP binding, binding, catalytic activity, kinase activity, lyase activity, nucleotide binding, oxidoreductase activity, shikimate 5-dehydrogenase activity, shikimate kinase activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups		
YDR128W	MTC5	Protein of unknown function; mtc5 is synthetically sick with cdc13-1 [Source:SGD;Acc:S000002535]	biological_process	fungal-type vacuole membrane, membrane, vacuolar membrane, vacuole	molecular_function, protein binding		
YDR129C	SAC6	Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton [Source:SGD;Acc:S000002536]	actin filament organization, bipolar cellular bud site selection, endocytosis, response to osmotic stress	actin cortical patch, actin filament bundle, mating projection tip	actin binding, actin filament binding, calcium ion binding, protein binding, protein binding, bridging		
YDR130C	FIN1	Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells; localization cell-cycle dependent; involved in Glc7p localization and regulation [Source:SGD;Acc:S000002537]	intermediate filament-based process, mitotic cell cycle spindle checkpoint, mitotic sister chromatid segregation, mitotic spindle stabilization, protein localization to kinetochore	astral microtubule, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, intermediate filament, nucleus, spindle, spindle pole, spindle pole body	microtubule binding, structural constituent of cytoskeleton		
YDR131C	YDR131C	F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex [Source:SGD;Acc:S000002538]	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex, vacuole	protein binding, ubiquitin-protein ligase activity		
YDR132C	YDR132C	Putative protein of unknown function [Source:SGD;Acc:S000002539]	biological_process, potassium ion transport	cytoplasm, membrane, nucleus, voltage-gated potassium channel complex	molecular_function, protein binding, voltage-gated potassium channel activity		
YDR133C	YDR133C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C [Source:SGD;Acc:S000002540]					
YDR135C	YCF1	Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR [Source:SGD;Acc:S000002542]	bilirubin transport, response to cadmium ion, response to metal ion, transmembrane transport, transport	integral to membrane, membrane, vacuolar membrane, vacuole	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, bilirubin transmembrane transporter activity, glutathione S-conjugate-exporting ATPase activity, nucleoside-triphosphatase activity, nucleotide binding		
YDR136C	VPS61	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect [Source:SGD;Acc:S000002543]					
YDR137W	RGP1	Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p [Source:SGD;Acc:S000002544]	cell cycle, cell division, mitosis, retrograde transport, endosome to Golgi	Golgi apparatus, Golgi membrane, Ric1p-Rgp1p complex, guanyl-nucleotide exchange factor complex	guanyl-nucleotide exchange factor activity		
YDR138W	HPR1	Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p [Source:SGD;Acc:S000002545]	DNA recombination, mRNA 3'-end processing, mRNA export from nucleus, response to DNA damage stimulus, transcription elongation from RNA polymerase II promoter, transcription-coupled nucleotide-excision repair	Cdc73/Paf1 complex, THO complex part of transcription export complex, nucleoplasmic THO complex, nucleus	nucleic acid binding		
YDR139C	RUB1	Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) [Source:SGD;Acc:S000002546]	protein neddylation	cytoplasm	protein binding, protein tag		
YDR140W	MTQ2	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC [Source:SGD;Acc:S000002547]	methylation, peptidyl-glutamine methylation, regulation of translation	cytoplasm, eRF1 methyltransferase complex, nucleus	S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, nucleic acid binding, protein methyltransferase activity, transferase activity		
YDR141C	DOP1	Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002548]	Golgi to endosome transport, cell morphogenesis, endoplasmic reticulum organization, protein transport, transport	Golgi apparatus, Golgi membrane, cytoplasm, endosome, membrane, mitochondrion, trans-Golgi network	binding, molecular_function		
YDR142C	PEX7	Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) [Source:SGD;Acc:S000002549]	protein import into peroxisome matrix, docking, protein transport, transport	cytoplasm, cytosol, peroxisome	peroxisome matrix targeting signal-2 binding, protein binding		
YDR143C	SAN1	Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins; contains intrinsically disordered regions that contribute to substrate recognition [Source:SGD;Acc:S000002550]	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, response to misfolded protein, response to stress	cytoplasm, nucleus	metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YDR144C	MKC7	GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p [Source:SGD;Acc:S000002551]	fungal-type cell wall organization, proteolysis	anchored to membrane, fungal-type cell wall, membrane, plasma membrane	aspartic-type endopeptidase activity, hydrolase activity, peptidase activity		
YDR145W	TAF12	Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A [Source:SGD;Acc:S000002552]	RNA polymerase II transcriptional preinitiation complex assembly, chromatin modification, histone acetylation, transcription initiation, DNA-dependent	SAGA complex, SLIK (SAGA-like) complex, nucleus, transcription factor TFIID complex	DNA binding, TBP-class protein binding, chromatin binding		
YDR146C	SWI5	Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase [Source:SGD;Acc:S000002553]	regulation of transcription involved in G1 phase of mitotic cell cycle	cytoplasm, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YDR147W	EKI1	Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway [Source:SGD;Acc:S000002554]	phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process	cytoplasm	ATP binding, choline kinase activity, ethanolamine kinase activity, kinase activity, nucleotide binding, transferase activity		
YDR148C	KGD2	Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated [Source:SGD;Acc:S000002555]	2-oxoglutarate metabolic process, metabolic process, mitochondrial genome maintenance, tricarboxylic acid cycle	mitochondrial nucleoid, mitochondrial oxoglutarate dehydrogenase complex, mitochondrion, oxoglutarate dehydrogenase complex	acyltransferase activity, dihydrolipoyllysine-residue succinyltransferase activity, transferase activity		
YDR149C	YDR149C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth [Source:SGD;Acc:S000002556]					
YDR150W	NUM1	Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex [Source:SGD;Acc:S000002557]	microtubule cytoskeleton organization, mitochondrial fission, mitochondrion inheritance, nuclear migration along microtubule	cell cortex, cellular bud tip, mitochondrion	protein binding, tubulin binding		
YDR151C	CTH1	Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis [Source:SGD;Acc:S000002558]	cellular iron ion homeostasis, nuclear-transcribed mRNA catabolic process	nucleus	RNA binding, mRNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YDR152W	GIR2	Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein [Source:SGD;Acc:S000002559]	translation	cytoplasm, polysome	molecular_function, protein binding		
YDR153C	ENT5	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin [Source:SGD;Acc:S000002560]	Golgi to endosome transport, early endosome to Golgi transport, late endosome to vacuole transport via multivesicular body sorting pathway, protein transport, transport	clathrin vesicle coat, cytoplasm, endosome, endosome membrane, membrane	clathrin binding, lipid binding, phosphatidylinositol-3,5-bisphosphate binding		
YDR154C	YDR154C	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein [Source:SGD;Acc:S000002561]					
YDR155C	CPR1	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A [Source:SGD;Acc:S000002562]	ascospore formation, cellular protein metabolic process, histone deacetylation, positive regulation of meiosis, protein folding, protein transport, transport	Set3 complex, cytoplasm, histone deacetylase complex, mitochondrion, nucleus	cyclosporin A binding, isomerase activity, peptide binding, peptidyl-prolyl cis-trans isomerase activity		
YDR156W	RPA14	RNA polymerase I subunit A14 [Source:SGD;Acc:S000002563]	regulation of cell size, transcription of nuclear rRNA large RNA polymerase I transcript	DNA-directed RNA polymerase I complex, nucleolus, nucleus	DNA-directed RNA polymerase activity, molecular_function		
YDR157W	YDR157W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002564]					
YDR158W	HOM2	Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis [Source:SGD;Acc:S000002565]	cellular amino acid biosynthetic process, cellular amino acid metabolic process, homoserine biosynthetic process, metabolic process, methionine biosynthetic process, methionine metabolic process, oxidation-reduction process, threonine biosynthetic process, threonine metabolic process	cytoplasm, nucleus, plasma membrane enriched fraction	NAD binding, NADP binding, aspartate-semialdehyde dehydrogenase activity, binding, catalytic activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, protein dimerization activity		
YDR159W	SAC3	Nuclear pore-associated protein, required for biogenesis of the small ribosomal subunit; forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus [Source:SGD;Acc:S000002566]	actin filament-based process, mRNA 3'-end processing, mRNA export from nucleus, mRNA transport, mitosis, protein export from nucleus, ribosomal small subunit biogenesis, transcription-coupled nucleotide-excision repair, transport	nuclear envelope, nuclear pore, nucleus, transcription export complex 2	protein binding		
YDR160W	SSY1	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes [Source:SGD;Acc:S000002567]	amino acid transport, response to amino acid stimulus, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	amino acid transmembrane transporter activity, molecular_function		
YDR161W	YDR161W	Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) [Source:SGD;Acc:S000002568]	ER-associated protein catabolic process	cytoplasm, nucleus	binding, molecular_function		
YDR162C	NBP2	Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p [Source:SGD;Acc:S000002569]	hyperosmotic response, negative regulation of protein kinase activity, response to heat	cytoplasm, nucleus	molecular_function, protein binding		
YDR163W	CWC15	Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p [Source:SGD;Acc:S000002570]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U2-type spliceosomal complex, nucleus, spliceosomal complex	molecular_function		
YDR164C	SEC1	Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function [Source:SGD;Acc:S000002571]	exocytosis, protein transport, transport, vesicle docking involved in exocytosis, vesicle fusion, vesicle-mediated transport	cellular bud neck, cellular bud tip, plasma membrane	SNARE binding		
YDR165W	TRM82	Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA [Source:SGD;Acc:S000002572]	tRNA methylation, tRNA processing	nucleus	protein binding, tRNA (guanine-N7-)-methyltransferase activity		
YDR166C	SEC5	Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis [Source:SGD;Acc:S000002573]	Golgi to plasma membrane transport, bipolar cellular bud site selection, cytokinesis, exocytosis, protein transport, transport, vesicle docking involved in exocytosis, vesicle fusion	cellular bud neck, cellular bud tip, exocyst, incipient cellular bud site, mating projection tip	molecular_function		
YDR167W	TAF10	Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification [Source:SGD;Acc:S000002574]	RNA polymerase II transcriptional preinitiation complex assembly, chromatin modification, histone acetylation, transcription initiation, DNA-dependent	SAGA complex, SLIK (SAGA-like) complex, nucleus, transcription factor TFIID complex	chromatin binding		
YDR168W	CDC37	Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding [Source:SGD;Acc:S000002575]	MAPKKK cascade involved in osmosensory signaling pathway, cell cycle, cell division, protein stabilization, regulation of cell cycle, regulation of stress-activated MAPK cascade, spindle pole body duplication in nuclear envelope	cytoplasm	unfolded protein binding		
YDR169C	STB3	Ribosomal RNA processing element (RRPE)-binding protein involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p [Source:SGD;Acc:S000002576]	positive regulation of transcription from RNA polymerase II promoter by glucose	cytoplasm, nucleus	sequence-specific DNA binding		
YDR169C-A	YDR169C-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028538]	biological_process	cellular_component	molecular_function		
YDR170C	SEC7	Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles [Source:SGD;Acc:S000002577]	ER to Golgi vesicle-mediated transport, autophagic vacuole assembly, intra-Golgi vesicle-mediated transport, protein transport, regulation of ARF protein signal transduction, transport	Golgi apparatus, Golgi-associated vesicle, cytoplasm, cytosol, intracellular, late endosome, trans-Golgi network	ARF guanyl-nucleotide exchange factor activity, binding		
YDR170W-A	YDR170W-A	Retrotransposon TYA Gag gene; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag; YDR170W-A is part of a mutant retrotransposon [Source:SGD;Acc:S000007227]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YDR171W	HSP42	Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock [Source:SGD;Acc:S000002578]	cytoskeleton organization, response to stress	chaperonin-containing T-complex, cytoplasm, cytoskeleton	unfolded protein binding		
YDR172W	SUP35	Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype [Source:SGD;Acc:S000002579]	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, translation, translational termination	cytoplasm, cytosol, translation release factor complex	GTP binding, GTPase activity, nucleotide binding, translation release factor activity		
YDR173C	ARG82	Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes [Source:SGD;Acc:S000002580]	arginine metabolic process, inositol phosphate biosynthetic process, negative regulation of transcription from RNA polymerase II promoter, phosphatidylinositol phosphorylation, positive regulation of transcription from RNA polymerase II promoter, protein stabilization, regulation of arginine metabolic process	nucleus	ATP binding, inositol 1,3,4,5,6-pentakisphosphate kinase activity, inositol tetrakisphosphate 3-kinase activity, inositol tetrakisphosphate 6-kinase activity, inositol trisphosphate 3-kinase activity, inositol trisphosphate 6-kinase activity, kinase activity, nucleotide binding, phosphatidylinositol 3-kinase activity, protein binding, bridging, transferase activity		
YDR174W	HMO1	Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase [Source:SGD;Acc:S000002581]	regulation of ribosomal protein gene transcription from RNA polymerase II promoter, regulation of transcription by chromatin organization, regulation of transcription from RNA polymerase I promoter	cytoplasm, nuclear chromatin, nucleolus, nucleus	DNA bending activity, DNA binding, double-stranded DNA binding, four-way junction DNA binding, protein binding		
YDR175C	RSM24	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000002582]	mitochondrial translation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDR176W	NGG1	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex [Source:SGD;Acc:S000002583]	chromatin modification, histone acetylation	Ada2/Gcn5/Ada3 transcription activator complex, SAGA complex, SLIK (SAGA-like) complex, nucleus	histone acetyltransferase activity, transcription cofactor activity		
YDR177W	UBC1	Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response [Source:SGD;Acc:S000002584]	ER-associated protein catabolic process, endocytosis, post-translational protein modification, protein monoubiquitination, protein polyubiquitination, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, regulation of protein metabolic process, response to stress, spore germination, vesicle organization	proteasome complex	ATP binding, acid-amino acid ligase activity, ligase activity, nucleotide binding, protein binding, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YDR178W	SDH4	Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain [Source:SGD;Acc:S000002585]	cellular respiration, electron transport chain, mitochondrial electron transport, succinate to ubiquinone, transport, tricarboxylic acid cycle	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial respiratory chain complex II, mitochondrion	heme binding, iron ion binding, metal ion binding, quinone binding, succinate dehydrogenase (ubiquinone) activity		
YDR179C	CSN9	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling [Source:SGD;Acc:S000002586]	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, cullin deneddylation	cytoplasm, nucleus, signalosome	molecular_function		
YDR179W-A	YDR179W-A	Putative protein of unknown function [Source:SGD;Acc:S000002587]	biological_process	cellular_component	molecular_function		
YDR180W	SCC2	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin [Source:SGD;Acc:S000002588]	2-micrometer plasmid partitioning, DNA repair, cell cycle, double-strand break repair, establishment of mitotic sister chromatid cohesion, establishment of protein localization to chromatin, mitotic chromosome condensation, protein localization to chromatin, rDNA condensation, response to DNA damage stimulus, tRNA gene clustering, transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	2-micrometer circle DNA, SMC loading complex, nuclear chromatin, nucleus	binding, molecular_function		
YDR181C	SAS4	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p [Source:SGD;Acc:S000002589]	chromatin modification, chromatin silencing at telomere, ubiquitin-dependent protein catabolic process	SAS acetyltransferase complex, cullin-RING ubiquitin ligase complex, nuclear chromatin, nuclear chromosome, telomeric region, nucleus	acetyltransferase activity, histone acetyltransferase activity, ubiquitin protein ligase binding		
YDR182W	CDC1	Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution [Source:SGD;Acc:S000002590]	DNA repair, actin cytoskeleton organization, cell cycle, cell division, cellular manganese ion homeostasis, dephosphorylation	endoplasmic reticulum, integral to membrane, membrane	hydrolase activity, metal ion binding, molecular_function		
YDR182W-A	YDR182W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028539]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YDR183C-A	YDR183C-A	Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028540]					
YDR183W	PLP1	Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators [Source:SGD;Acc:S000002591]	negative regulation of signal transduction, positive regulation of transcription from RNA polymerase II promoter by pheromones, protein folding, response to pheromone	cellular_component, cytoplasm	G-protein beta/gamma-subunit complex binding		
YDR184C	ATC1	Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern [Source:SGD;Acc:S000002592]	bipolar cellular bud site selection, response to stress	cytoplasm, nucleus	molecular_function		
YDR185C	UPS3	Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations [Source:SGD;Acc:S000002593]	mitochondrion morphogenesis	extrinsic to mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion	molecular_function		
YDR186C	YDR186C	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000002594]	biological_process	cytoplasm, ribosome	molecular_function		
YDR187C	YDR187C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W [Source:SGD;Acc:S000002595]					
YDR188W	CCT6	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif [Source:SGD;Acc:S000002596]	cellular protein metabolic process, protein folding	chaperonin-containing T-complex, cytoplasm	ATP binding, nucleotide binding, unfolded protein binding		
YDR189W	SLY1	Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex [Source:SGD;Acc:S000002597]	ER to Golgi vesicle-mediated transport, positive regulation of SNARE complex assembly, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle docking involved in exocytosis, vesicle fusion with Golgi apparatus, vesicle-mediated transport	ER to Golgi transport vesicle, Golgi membrane, SNARE complex, cytoplasm, endoplasmic reticulum, membrane	SNARE binding, syntaxin binding		
YDR190C	RVB1	Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as pontin; member of the RUVB-like protein family [Source:SGD;Acc:S000002598]	DNA repair, chromatin modification, chromatin remodeling, regulation of transcription from RNA polymerase II promoter, response to DNA damage stimulus	ASTRA complex, Ino80 complex, Swr1 complex, chromatin remodeling complex, nucleus	ATP binding, ATP-dependent 3'-5' DNA helicase activity, ATPase activity, DNA helicase activity, helicase activity, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding		
YDR191W	HST4	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism [Source:SGD;Acc:S000002599]	chromatin silencing, chromatin silencing at telomere, histone deacetylation, protein deacetylation, short-chain fatty acid metabolic process	cytoplasm, nucleus	DNA binding, NAD+ binding, histone deacetylase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, metal ion binding, zinc ion binding		
YDR192C	NUP42	Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p [Source:SGD;Acc:S000002600]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YDR193W	YDR193W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002601]					
YDR194C	MSS116	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing [Source:SGD;Acc:S000002602]	Group I intron splicing, Group II intron splicing, RNA folding, RNA splicing, mRNA processing, regulation of translation	mitochondrial matrix, mitochondrion	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, RNA strand annealing activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YDR194W-A	YDR194W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028541]	biological_process	cellular_component	molecular_function		
YDR195W	REF2	RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes [Source:SGD;Acc:S000002603]	mRNA processing, snoRNA 3'-end processing, termination of RNA polymerase II transcription, exosome-dependent, termination of RNA polymerase II transcription, poly(A)-coupled	mRNA cleavage and polyadenylation specificity factor complex, nucleus	DNA binding, RNA binding		
YDR196C	CAB5	Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002604]	coenzyme A biosynthetic process	endoplasmic reticulum, mitochondrion, nuclear envelope, nucleus	ATP binding, dephospho-CoA kinase activity, kinase activity, nucleotide binding, transferase activity		
YDR197W	CBS2	Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader [Source:SGD;Acc:S000002605]	oxidation-reduction process, pantothenate biosynthetic process, positive regulation of mitochondrial translation, regulation of translation	cytoplasm, extrinsic to mitochondrial inner membrane, mitochondrial ribosome, mitochondrion	NADP binding, coenzyme binding, oxidoreductase activity, translation regulator activity		
YDR198C	RKM2	Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp [Source:SGD;Acc:S000002606]	peptidyl-lysine monomethylation, peptidyl-lysine trimethylation	cellular_component	methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity		
YDR199W	YDR199W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity [Source:SGD;Acc:S000002607]					
YDR200C	VPS64	Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000002608]	cell cycle, protein targeting to vacuole, protein transport, re-entry into mitotic cell cycle after pheromone arrest, transport	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function, protein binding		
YDR201W	SPC19	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body [Source:SGD;Acc:S000002609]	cell cycle, cell division, chromosome segregation, microtubule nucleation, mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization	DASH complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle, spindle microtubule, spindle pole body	microtubule binding, structural constituent of cytoskeleton		
YDR202C	RAV2	Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme [Source:SGD;Acc:S000002610]	protein transport, regulation of protein complex assembly, transport, vacuolar acidification	RAVE complex, cytoplasm, early endosome membrane, endosome, membrane	molecular_function		
YDR203W	YDR203W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002611]					
YDR204W	COQ4	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex [Source:SGD;Acc:S000002612]	ubiquinone biosynthetic process	membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YDR205W	MSC2	Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids [Source:SGD;Acc:S000002613]	cation transport, cellular zinc ion homeostasis, ion transport, transmembrane transport, transport, zinc ion transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear membrane, nucleus	cation transmembrane transporter activity, metal ion transmembrane transporter activity, zinc ion transmembrane transporter activity		
YDR206W	EBS1	Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors [Source:SGD;Acc:S000002614]	negative regulation of translation, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	chromosome, telomeric region, cytoplasm, cytoplasmic mRNA processing body, nucleus	molecular_function		
YDR207C	UME6	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p [Source:SGD;Acc:S000002615]	ascospore formation, chromatin modification, chromosome organization, histone deacetylation, negative regulation of transcription during mitosis, positive regulation of meiosis, reciprocal meiotic recombination, regulation of transcription, DNA-dependent, spore germination	Rpd3L complex, Rpd3L-Expanded complex, nucleus	DNA binding, histone deacetylase activity, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YDR208W	MSS4	Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation [Source:SGD;Acc:S000002616]	ascospore-type prospore formation, phosphatidylinositol metabolic process, phosphatidylinositol phosphorylation	nucleus, plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding, kinase activity, nucleotide binding, phosphatidylinositol phosphate kinase activity, transferase activity		
YDR209C	YDR209C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W. [Source:SGD;Acc:S000002617]					
YDR210C-C	YDR210C-C	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007409]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YDR210C-D	YDR210C-D	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007410]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YDR210W	YDR210W	Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000002618]	biological_process	cellular_component, membrane, plasma membrane	molecular_function		
YDR210W-A	YDR210W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007392]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YDR210W-B	YDR210W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007393]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YDR211W	GCD6	Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000002619]	RNA metabolic process, biosynthetic process, regulation of translation, regulation of translational initiation, translation	eukaryotic translation initiation factor 2B complex, guanyl-nucleotide exchange factor complex	binding, guanyl-nucleotide exchange factor activity, nucleotidyltransferase activity, transferase activity, translation initiation factor activity		
YDR212W	TCP1	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein [Source:SGD;Acc:S000002620]	cellular protein metabolic process, protein folding	chaperonin-containing T-complex, cytoplasm, plasma membrane enriched fraction	ATP binding, nucleotide binding, unfolded protein binding		
YDR213W	UPC2	Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion [Source:SGD;Acc:S000002621]	regulation of transcription, DNA-dependent, steroid metabolic process, sterol biosynthetic process	cytoplasm, membrane, nucleus, perinuclear region of cytoplasm	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YDR214W	AHA1	Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock [Source:SGD;Acc:S000002622]	protein folding, response to stress	cytoplasm	ATPase activator activity, chaperone binding		
YDR215C	YDR215C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein [Source:SGD;Acc:S000002623]					
YDR216W	ADR1	Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization [Source:SGD;Acc:S000002624]	negative regulation of transcription from RNA polymerase II promoter by glucose, peroxisome organization, regulation of carbohydrate metabolic process	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YDR217C	RAD9	DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate [Source:SGD;Acc:S000002625]	DNA damage checkpoint, DNA repair, cell cycle, intra-S DNA damage checkpoint, mitotic cell cycle G1/S transition DNA damage checkpoint, negative regulation of DNA replication, nucleotide-excision repair, positive regulation of transcription from RNA polymerase II promoter, regulation of cell cycle, response to DNA damage stimulus	chromatin, intracellular, nucleus	double-stranded DNA binding, histone binding		
YDR218C	SPR28	Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation [Source:SGD;Acc:S000002626]	cell cycle, cell division, cell morphogenesis, fungal-type cell wall organization	cellular bud neck, cellular bud neck septin ring, membrane, septin complex	GTP binding, nucleotide binding, structural constituent of cytoskeleton		
YDR219C	MFB1	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding [Source:SGD;Acc:S000002627]	mitochondrion organization, ubiquitin-dependent protein catabolic process	extrinsic to mitochondrial outer membrane, mitochondrion, ubiquitin ligase complex	molecular_function, protein binding		
YDR220C	YDR220C	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein [Source:SGD;Acc:S000002628]					
YDR221W	GTB1	Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER [Source:SGD;Acc:S000002629]	polysaccharide biosynthetic process, protein N-linked glycosylation	alpha-glucosidase II complex, endoplasmic reticulum, endoplasmic reticulum lumen	alpha-glucosidase activity, protein binding		
YDR222W	YDR222W	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000002630]	biological_process, response to oxidative stress	cytoplasm	molecular_function		
YDR223W	CRF1	Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain [Source:SGD;Acc:S000002631]	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter	cytoplasm, nuclear chromatin, nucleus	transcription corepressor activity		
YDR224C	HTB1	Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation [Source:SGD;Acc:S000002632]	chromatin assembly or disassembly, nucleosome assembly, postreplication repair	chromosome, nuclear nucleosome, nucleosome, nucleus, replication fork protection complex	DNA binding		
YDR225W	HTA1	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p [Source:SGD;Acc:S000002633]	DNA repair, chromatin assembly or disassembly, nucleosome assembly, response to DNA damage stimulus	chromosome, nuclear nucleosome, nucleosome, nucleus, replication fork protection complex	DNA binding		
YDR226W	ADK1	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence [Source:SGD;Acc:S000002634]	ADP biosynthetic process, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, nucleotide metabolic process	cytoplasm, cytosol, mitochondrial intermembrane space, mitochondrion	ATP binding, adenylate kinase activity, kinase activity, nucleobase, nucleoside, nucleotide kinase activity, nucleotide binding, nucleotide kinase activity, phosphotransferase activity, phosphate group as acceptor, transferase activity		
YDR227W	SIR4	Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan [Source:SGD;Acc:S000002635]	chromatin silencing, double-strand break repair via nonhomologous end joining, loss of chromatin silencing involved in replicative cell aging	chromatin silencing complex, nuclear telomere cap complex, nuclear telomeric heterochromatin, nucleus	DNA binding, double-stranded DNA binding, histone binding, nucleosome binding, structural constituent of chromatin		
YDR228C	PCF11	mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p) [Source:SGD;Acc:S000002636]	mRNA cleavage, mRNA polyadenylation, mRNA processing, termination of RNA polymerase II transcription, transcription termination, DNA-dependent	mRNA cleavage factor complex, nucleus	RNA binding, RNA polymerase II core binding, mRNA binding		
YDR229W	IVY1	Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase [Source:SGD;Acc:S000002637]	vacuole fusion, non-autophagic	fungal-type vacuole membrane, membrane, vacuolar membrane, vacuole	phospholipid binding		
YDR230W	YDR230W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 [Source:SGD;Acc:S000002638]					
YDR231C	COX20	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase [Source:SGD;Acc:S000002639]	aerobic respiration, mitochondrial respiratory chain complex IV assembly, protein processing	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	unfolded protein binding		
YDR232W	HEM1	5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p [Source:SGD;Acc:S000002640]	biosynthetic process, heme biosynthetic process, metabolic process, tetrapyrrole biosynthetic process	mitochondrial matrix, mitochondrion	5-aminolevulinate synthase activity, acyltransferase activity, catalytic activity, pyridoxal phosphate binding, transferase activity, transferase activity, transferring nitrogenous groups		
YDR233C	RTN1	ER membrane protein that interacts with Sey1p to maintain ER morphology; interacts with exocyst subunit Sec6p, with Yip3p, and with Sbh1p; null mutant has an altered ER morphology; member of the RTNLA (reticulon-like A) subfamily [Source:SGD;Acc:S000002641]	endoplasmic reticulum organization, protein import into nucleus, protein localization	Golgi apparatus, cortical endoplasmic reticulum, endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion	molecular_function		
YDR234W	LYS4	Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway [Source:SGD;Acc:S000002642]	cellular amino acid biosynthetic process, lysine biosynthetic process, lysine biosynthetic process via aminoadipic acid, metabolic process	mitochondrion	4 iron, 4 sulfur cluster binding, homoaconitate hydratase activity, iron-sulfur cluster binding, lyase activity, metal ion binding		
YDR235W	PRP42	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats [Source:SGD;Acc:S000002643]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, nucleus, ribonucleoprotein complex, spliceosomal complex	RNA binding		
YDR236C	FMN1	Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane [Source:SGD;Acc:S000002644]	FMN biosynthetic process, riboflavin biosynthetic process	endoplasmic reticulum, membrane, microsome, mitochondrial inner membrane, mitochondrion	ATP binding, kinase activity, metal ion binding, nucleotide binding, riboflavin kinase activity, transferase activity		
YDR237W	MRPL7	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000002645]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDR238C	SEC26	Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) [Source:SGD;Acc:S000002646]	ER to Golgi vesicle-mediated transport, intracellular protein transport, protein transport, transport, vesicle-mediated transport	COPI coated vesicle membrane, COPI vesicle coat, Golgi apparatus, Golgi membrane, coated vesicle, cytoplasm, cytoplasmic vesicle, membrane, membrane coat	binding, molecular_function, structural molecule activity		
YDR239C	YDR239C	Protein of unknown function that may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000002647]	biological_process	cytoplasm, ribosome	molecular_function		
YDR240C	SNU56	Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex [Source:SGD;Acc:S000002648]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, commitment complex, nucleus, ribonucleoprotein complex, spliceosomal complex	RNA binding, mRNA binding		
YDR241W	BUD26	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay [Source:SGD;Acc:S000002649]					
YDR242W	AMD2	Putative amidase [Source:SGD;Acc:S000002650]	biological_process	cellular_component	amidase activity, carbon-nitrogen ligase activity, with glutamine as amido-N-donor, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides		
YDR243C	PRP28	RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site [Source:SGD;Acc:S000002651]	RNA splicing, cis assembly of pre-catalytic spliceosome, mRNA processing	U5 snRNP, cytoplasm, nucleus, spliceosomal complex	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YDR244W	PEX5	Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions [Source:SGD;Acc:S000002652]	protein import into peroxisome matrix, docking, protein transport, transport	cytoplasm, cytosol, membrane, peroxisomal membrane, peroxisome	binding, peroxisome matrix targeting signal-1 binding, protein binding, protein binding, bridging		
YDR245W	MNN10	Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family [Source:SGD;Acc:S000002653]	N-glycan processing, barrier septum formation, cell wall mannoprotein biosynthetic process, substituted mannan metabolic process	Golgi apparatus, alpha-1,6-mannosyltransferase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	alpha-1,6-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups		
YDR246W	TRS23	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4 [Source:SGD;Acc:S000002654]	ER to Golgi vesicle-mediated transport, chromosome organization, transport, vesicle-mediated transport	Golgi apparatus, TRAPP complex, cis-Golgi network, endoplasmic reticulum	Rab guanyl-nucleotide exchange factor activity		
YDR246W-A	YDR246W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028542]	biological_process	cellular_component	molecular_function		
YDR247W	VHS1	Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p [Source:SGD;Acc:S000002655]	G1/S transition of mitotic cell cycle, cell cycle, protein phosphorylation	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDR248C	YDR248C	Putative protein of unknown function; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1 [Source:SGD;Acc:S000002656]	D-gluconate metabolic process, carbohydrate metabolic process, sulfate assimilation	cytoplasm	ATP binding, gluconokinase activity, kinase activity, nucleotide binding, transferase activity, transferase activity, transferring phosphorus-containing groups		
YDR249C	YDR249C	Putative protein of unknown function [Source:SGD;Acc:S000002657]	biological_process	cellular_component	molecular_function		
YDR250C	YDR250C	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000002658]					
YDR251W	PAM1	Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype [Source:SGD;Acc:S000002659]	oxidation-reduction process, pseudohyphal growth	cellular bud, cellular bud neck	NADP binding, coenzyme binding, molecular_function, oxidoreductase activity		
YDR252W	BTT1	Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 [Source:SGD;Acc:S000002660]	'de novo' cotranslational protein folding, protein transport, transport	CCR4-NOT complex, cytoplasm, nascent polypeptide-associated complex, nucleus	unfolded protein binding		
YDR253C	MET32	Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p [Source:SGD;Acc:S000002661]	sulfur amino acid metabolic process	cytoplasm, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YDR254W	CHL4	Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore subcomplex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p [Source:SGD;Acc:S000002662]	cell cycle, cell division, chromosome segregation, establishment of meiotic sister chromatid cohesion, establishment of mitotic sister chromatid cohesion, kinetochore assembly, maintenance of meiotic sister chromatid cohesion, meiosis, mitosis, protein localization to chromosome, centromeric region	chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome outer kinetochore, kinetochore, nucleus	structural molecule activity		
YDR255C	RMD5	Conserved protein that has an E3-like ubiquitin ligase activity necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; also required for sporulation; has a degenerate RING finger domain [Source:SGD;Acc:S000002663]	meiosis, negative regulation of gluconeogenesis, proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, sporulation resulting in formation of a cellular spore	GID complex, cytoplasm, cytosol	ubiquitin-protein ligase activity		
YDR256C	CTA1	Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation [Source:SGD;Acc:S000002664]	age-dependent response to reactive oxygen species, hydrogen peroxide catabolic process, oxidation-reduction process, response to oxidative stress, response to reactive oxygen species	mitochondrial matrix, peroxisomal matrix, peroxisome	catalase activity, heme binding, iron ion binding, metal ion binding, oxidoreductase activity, peroxidase activity		
YDR257C	RKM4	Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein [Source:SGD;Acc:S000002665]	peptidyl-lysine monomethylation	nucleus	methyltransferase activity, protein binding, protein-lysine N-methyltransferase activity, transferase activity		
YDR258C	HSP78	Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates [Source:SGD;Acc:S000002666]	cellular response to heat, mitochondrial genome maintenance, positive regulation of mitochondrial translation in response to stress, protein import into mitochondrial matrix, protein refolding, protein stabilization, protein unfolding, response to stress	mitochondrial matrix, mitochondrion	ATP binding, ATPase activity, misfolded protein binding, nucleoside-triphosphatase activity, nucleotide binding		
YDR259C	YAP6	Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism [Source:SGD;Acc:S000002667]	positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YDR260C	SWM1	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation [Source:SGD;Acc:S000002668]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, ascospore wall assembly, cell cycle, cell division, meiosis, mitosis, protein ubiquitination, regulation of mitotic metaphase/anaphase transition	anaphase-promoting complex, nucleus	molecular_function		
YDR261C	EXG2	Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor [Source:SGD;Acc:S000002669]	carbohydrate metabolic process, cellular cell wall organization, fungal-type cell wall organization, metabolic process	anchored to membrane, fungal-type cell wall, membrane, plasma membrane	catalytic activity, cation binding, glucan exo-1,3-beta-glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds		
YDR261C-C	YDR261C-C	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; in YDRCTY1-3 TYB is mutant and probably non-functional [Source:SGD;Acc:S000007394]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YDR261C-D	YDR261C-D	Retrotransposon TYA Gag and TYB Pol genes; in YDRCTY1-3 TYB is mutant and probably non-functional [Source:SGD;Acc:S000007395]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YDR261W-A	YDR261W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007396]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YDR261W-B	YDR261W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007397]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YDR262W	YDR262W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment [Source:SGD;Acc:S000002670]	biological_process	fungal-type vacuole, vacuole	molecular_function		
YDR263C	DIN7	Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination [Source:SGD;Acc:S000002671]	DNA repair, response to DNA damage stimulus	mitochondrion, nucleus	DNA binding, catalytic activity, endonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding, nuclease activity		
YDR264C	AKR1	Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats [Source:SGD;Acc:S000002672]	endocytosis, pheromone-dependent signal transduction involved in conjugation with cellular fusion, protein palmitoylation, protein targeting to membrane	Golgi apparatus, Golgi membrane, early endosome membrane, endosome, integral to membrane, membrane	acyltransferase activity, metal ion binding, protein binding, protein-cysteine S-palmitoleyltransferase activity, transferase activity, zinc ion binding		
YDR265W	PEX10	Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders [Source:SGD;Acc:S000002673]	peroxisome organization, protein import into peroxisome matrix, protein ubiquitination	membrane, peroxisomal membrane, peroxisome	metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YDR266C	YDR266C	Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain [Source:SGD;Acc:S000002674]	biological_process	cytoplasm, intracellular, ribosome	metal ion binding, molecular_function, protein binding, zinc ion binding		
YDR267C	CIA1	WD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; similar to the human Ciao1 protein; YDR267C is an essential gene [Source:SGD;Acc:S000002675]	iron-sulfur cluster assembly, ribosomal large subunit export from nucleus, tRNA wobble uridine modification	cytoplasm, cytosol, nucleus	molecular_function, protein binding		
YDR268W	MSW1	Mitochondrial tryptophanyl-tRNA synthetase [Source:SGD;Acc:S000002676]	mitochondrial tryptophanyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation, tryptophanyl-tRNA aminoacylation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, tryptophan-tRNA ligase activity		
YDR269C	YDR269C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002677]					
YDR270W	CCC2	Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases [Source:SGD;Acc:S000002678]	ATP biosynthetic process, cellular iron ion homeostasis, copper ion export, copper ion transport, ion transport, metabolic process, metal ion transport, transmembrane transport, transport	Golgi apparatus, integral to membrane, membrane, trans-Golgi network transport vesicle membrane	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, cation-transporting ATPase activity, copper ion binding, copper-exporting ATPase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, metal ion binding, metal ion transmembrane transporter activity, nucleotide binding		
YDR271C	YDR271C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W [Source:SGD;Acc:S000002679]					
YDR272W	GLO2	Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate [Source:SGD;Acc:S000002680]	cellular carbohydrate metabolic process, methylglyoxal catabolic process to D-lactate	cytoplasm	hydrolase activity, hydroxyacylglutathione hydrolase activity, metal ion binding		
YDR273W	DON1	Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II [Source:SGD;Acc:S000002681]	ascospore wall assembly, cell cycle, cell division, meiosis, sporulation resulting in formation of a cellular spore	membrane, prospore membrane	molecular_function, protein binding		
YDR274C	YDR274C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002682]					
YDR275W	BSC2	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression [Source:SGD;Acc:S000002683]	biological_process	integral to membrane, lipid particle, membrane	molecular_function		
YDR276C	PMP3	Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential [Source:SGD;Acc:S000002684]	cation transport, regulation of membrane potential	integral to membrane, membrane, plasma membrane	molecular_function		
YDR277C	MTH1	Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation [Source:SGD;Acc:S000002685]	glucose transport, signal transduction	cellular_component	molecular_function		
YDR278C	YDR278C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002686]					
YDR279W	RNH202	Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome [Source:SGD;Acc:S000002687]	DNA replication, removal of RNA primer, RNA catabolic process	nucleus, ribonuclease H2 complex	ribonuclease H activity		
YDR280W	RRP45	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9) [Source:SGD;Acc:S000002688]	RNA processing, U1 snRNA 3'-end processing, U4 snRNA 3'-end processing, U5 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nonfunctional rRNA decay, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, polyadenylation-dependent snoRNA 3'-end processing, rRNA processing	cytoplasm, cytoplasmic exosome (RNase complex), exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleus	3'-5'-exoribonuclease activity, RNA binding, molecular_function		
YDR281C	PHM6	Protein of unknown function, expression is regulated by phosphate levels [Source:SGD;Acc:S000002689]	biological_process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YDR282C	YDR282C	Putative protein of unknown function [Source:SGD;Acc:S000002690]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YDR283C	GCN2	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control [Source:SGD;Acc:S000002691]	DNA damage checkpoint, cellular amino acid biosynthetic process, protein phosphorylation, regulation of translational initiation, response to stress, translation	cytosolic ribosome	ATP binding, aminoacyl-tRNA ligase activity, eukaryotic translation initiation factor 2alpha kinase activity, kinase activity, ligase activity, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDR284C	DPP1	Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism [Source:SGD;Acc:S000002692]	phospholipid metabolic process, signal transduction	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	catalytic activity, diacylglycerol pyrophosphate phosphatase activity, hydrolase activity, phosphatidate phosphatase activity		
YDR285W	ZIP1	Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate [Source:SGD;Acc:S000002693]	meiosis, reciprocal meiotic recombination, synapsis	chromosome, nucleus, transverse filament	SUMO polymer binding, chromatin binding		
YDR286C	YDR286C	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site [Source:SGD;Acc:S000002694]	biological_process, electron transport chain, transport	cellular_component	molecular_function		
YDR287W	INM2	Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy [Source:SGD;Acc:S000002695]	inositol phosphate dephosphorylation	cellular_component	hydrolase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1(or 4)-monophosphatase activity, metal ion binding		
YDR288W	NSE3	Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth [Source:SGD;Acc:S000002696]	DNA recombination, DNA repair, response to DNA damage stimulus	Smc5-Smc6 complex, cytoplasm, nucleus	DNA binding		
YDR289C	RTT103	Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition [Source:SGD;Acc:S000002697]	negative regulation of transposition, RNA-mediated, termination of RNA polymerase II transcription, poly(A)-coupled	cellular_component, nucleus	DNA binding, RNA polymerase II core binding		
YDR290W	YDR290W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103 [Source:SGD;Acc:S000002698]					
YDR291W	HRQ1	Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS) [Source:SGD;Acc:S000002699]	biological_process, response to stress	nucleus	ATP binding, ATP-dependent helicase activity, helicase activity, hydrolase activity, molecular_function, nucleic acid binding, nucleotide binding		
YDR292C	SRP101	Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p [Source:SGD;Acc:S000002700]	SRP-dependent cotranslational protein targeting to membrane, protein targeting to ER, transport	endoplasmic reticulum, endoplasmic reticulum membrane, membrane, signal recognition particle receptor complex	GTP binding, nucleoside-triphosphatase activity, nucleotide binding, receptor activity, signal recognition particle binding		
YDR293C	SSD1	RNA-binding protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence [Source:SGD;Acc:S000002701]	cell cycle, cell division, chronological cell aging, fungal-type cell wall organization, mitosis, replicative cell aging	cytoplasm	RNA binding, mRNA 5'-UTR binding, mRNA binding, ribonuclease activity		
YDR294C	DPL1	Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate [Source:SGD;Acc:S000002702]	calcium-mediated signaling, carboxylic acid metabolic process, cellular response to starvation, sphingolipid metabolic process	endoplasmic reticulum	carboxy-lyase activity, catalytic activity, lyase activity, pyridoxal phosphate binding, sphinganine-1-phosphate aldolase activity		
YDR295C	HDA2	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance [Source:SGD;Acc:S000002703]	chromatin modification, gene silencing by RNA, gene silencing involved in chronological cell aging, histone deacetylation, negative regulation of transcription from RNA polymerase II promoter	HDA1 complex, nucleus	DNA binding, chromatin binding, histone deacetylase activity		
YDR296W	MHR1	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress [Source:SGD;Acc:S000002704]	DNA recombination, cellular response to oxidative stress, mitochondrial genome maintenance, positive regulation of mitochondrial DNA replication, regulation of transcription, DNA-dependent	mitochondrion, nucleus	DNA binding, recombinase activity, single-stranded DNA binding		
YDR297W	SUR2	Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis [Source:SGD;Acc:S000002705]	fatty acid biosynthetic process, lipid biosynthetic process, oxidation-reduction process, sphingolipid metabolic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	iron ion binding, oxidoreductase activity, sphingosine hydroxylase activity		
YDR298C	ATP5	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated [Source:SGD;Acc:S000002706]	ATP biosynthetic process, ATP synthesis coupled proton transport, ion transport, proton transport, transport	membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase complex, mitochondrial proton-transporting ATP synthase, stator stalk, mitochondrion, plasma membrane, proton-transporting ATP synthase complex, catalytic core F(1)	hydrogen ion transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism		
YDR299W	BFR2	Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock [Source:SGD;Acc:S000002707]	protein transport, rRNA processing, transport, vesicle-mediated transport	90S preribosome, nucleolus, nucleus	molecular_function		
YDR300C	PRO1	Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis [Source:SGD;Acc:S000002708]	cellular amino acid biosynthetic process, proline biosynthetic process	cytoplasm	ATP binding, RNA binding, glutamate 5-kinase activity, kinase activity, nucleotide binding, transferase activity		
YDR301W	CFT1	RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF [Source:SGD;Acc:S000002709]	mRNA cleavage, mRNA polyadenylation, mRNA processing, termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex, mRNA cleavage factor complex, mitochondrion, nucleus	RNA binding, nucleic acid binding		
YDR302W	GPI11	ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog [Source:SGD;Acc:S000002710]	GPI anchor biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	mannose-ethanolamine phosphotransferase activity		
YDR303C	RSC3	Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p [Source:SGD;Acc:S000002711]	ATP-dependent chromatin remodeling, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, chromatin modification, nucleosome disassembly, regulation of DNA replication involved in S phase, regulation of cell cycle, regulation of transcription, DNA-dependent, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	DNA binding, DNA-dependent ATPase activity, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YDR304C	CPR5	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER [Source:SGD;Acc:S000002712]	biological_process, protein folding	cytoplasm, endoplasmic reticulum, endoplasmic reticulum lumen	isomerase activity, peptide binding, peptidyl-prolyl cis-trans isomerase activity		
YDR305C	HNT2	Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins [Source:SGD;Acc:S000002713]	nucleoside catabolic process	cytoplasm, mitochondrion, nucleus	bis(5'-adenosyl)-triphosphatase activity, catalytic activity, hydrolase activity, nucleoside-triphosphatase activity		
YDR306C	YDR306C	F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain [Source:SGD;Acc:S000002714]	ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity		
YDR307W	YDR307W	Putative protein of unknown function [Source:SGD;Acc:S000002715]	biological_process, protein O-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity, mannosyltransferase activity, molecular_function, transferase activity, transferase activity, transferring glycosyl groups		
YDR308C	SRB7	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p [Source:SGD;Acc:S000002716]	transcription from RNA polymerase II promoter	mediator complex, nucleus			
YDR309C	GIC2	Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region [Source:SGD;Acc:S000002717]	Rho protein signal transduction, axial cellular bud site selection, establishment of cell polarity, regulation of cell shape, regulation of exit from mitosis	actin cap, cell cortex, cellular bud neck, cellular bud tip, cytoplasm, cytoskeleton, incipient cellular bud site, mating projection tip, plasma membrane	Rho GTPase activator activity, Rho GTPase binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding		
YDR310C	SUM1	Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint [Source:SGD;Acc:S000002718]	DNA-dependent DNA replication initiation, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, regulation of mitosis, sporulation resulting in formation of a cellular spore	nucleus	DNA binding, DNA replication origin binding, sequence-specific DNA binding		
YDR311W	TFB1	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators [Source:SGD;Acc:S000002719]	DNA repair, nucleotide-excision repair, phosphorylation of RNA polymerase II C-terminal domain, response to DNA damage stimulus	core TFIIH complex, holo TFIIH complex, nucleotide-excision repair factor 3 complex, nucleus	phosphatidylinositol-3-phosphate binding, phosphatidylinositol-5-phosphate binding		
YDR312W	SSF2	Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family [Source:SGD;Acc:S000002720]	conjugation with cellular fusion, ribosomal large subunit assembly, ribosome biogenesis	nucleolus, nucleus	rRNA binding		
YDR313C	PIB1	RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain [Source:SGD;Acc:S000002721]	protein ubiquitination	endosome, endosome membrane, fungal-type vacuole membrane, late endosome, membrane, vacuolar membrane, vacuole	ligase activity, metal ion binding, phosphatidylinositol-3-phosphate binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YDR314C	RAD34	Protein involved in nucleotide excision repair (NER); homologous to RAD4 [Source:SGD;Acc:S000002722]	DNA repair, nucleotide-excision repair, response to DNA damage stimulus	nucleus	damaged DNA binding, molecular_function		
YDR315C	IPK1	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable [Source:SGD;Acc:S000002723]	inositol phosphate biosynthetic process, nuclear-transcribed mRNA catabolic process, non-stop decay	nucleus	ATP binding, inositol pentakisphosphate 2-kinase activity, kinase activity, nucleotide binding, transferase activity		
YDR316W	OMS1	Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations [Source:SGD;Acc:S000002724]	biological_process	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion	S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, transferase activity		
YDR316W-A	YDR316W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007398]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding, nucleic acid binding		
YDR316W-B	YDR316W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007399]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YDR317W	HIM1	Protein of unknown function involved in DNA repair [Source:SGD;Acc:S000002725]	DNA repair, response to DNA damage stimulus	cellular_component	molecular_function		
YDR318W	MCM21	Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules [Source:SGD;Acc:S000002726]	cell cycle, cell division, chromosome segregation, establishment of mitotic sister chromatid cohesion, meiosis, mitosis	COMA complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, kinetochore, nucleus	molecular_function		
YDR319C	YDR319C	Putative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens [Source:SGD;Acc:S000002727]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YDR320C	SWA2	Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles [Source:SGD;Acc:S000002728]	clathrin coat disassembly, endoplasmic reticulum inheritance, positive regulation of ATPase activity	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane	binding, clathrin binding, heat shock protein binding, protein binding, ubiquitin binding		
YDR320C-A	DAD4	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000007604]	cell cycle, cell division, chromosome segregation, mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization	DASH complex, chromosome, centromeric region, condensed chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle	microtubule binding		
YDR320W-B	YDR320W-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DAD4/YDR320C-A [Source:SGD;Acc:S000028821]					
YDR321W	ASP1	Cytosolic L-asparaginase, involved in asparagine catabolism [Source:SGD;Acc:S000002729]	asparagine catabolic process, asparagine metabolic process, cellular amino acid metabolic process	cytoplasm, cytosol, intracellular	asparaginase activity, hydrolase activity		
YDR322C-A	TIM11	Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase [Source:SGD;Acc:S000007255]	ATP biosynthetic process, ATP synthesis coupled proton transport, cristae formation, ion transport, protein oligomerization, proton transport, transport	membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrion, proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism, structural molecule activity		
YDR322W	MRPL35	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000002730]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDR323C	PEP7	Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance [Source:SGD;Acc:S000002731]	Golgi to endosome transport, Golgi to vacuole transport, vacuole inheritance, vesicle docking involved in exocytosis, vesicle fusion	cytoplasm, external side of endosome membrane, intracellular, membrane, vacuolar membrane, vacuole	metal ion binding, phosphatidylinositol-3-phosphate binding, zinc ion binding		
YDR324C	UTP4	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript [Source:SGD;Acc:S000002732]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of transcription from RNA polymerase I promoter, rRNA processing, ribosome biogenesis	90S preribosome, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome, t-UTP complex	molecular_function, protein binding		
YDR325W	YCG1	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus [Source:SGD;Acc:S000002733]	cell cycle, cell division, chromosome condensation, meiotic chromosome condensation, mitosis, mitotic chromosome condensation, mitotic sister chromatid segregation, rDNA condensation, tRNA gene clustering	chromosome, cytoplasm, nuclear condensin complex, nucleus	binding, molecular_function		
YDR326C	YSP2	Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification [Source:SGD;Acc:S000002734]	apoptosis	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YDR327W	YDR327W	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1 [Source:SGD;Acc:S000002735]					
YDR328C	SKP1	Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase [Source:SGD;Acc:S000002736]	G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cytokinesis, kinetochore assembly, protein complex assembly, protein neddylation, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, regulation of exit from mitosis, regulation of protein complex assembly, septin ring assembly, ubiquitin-dependent protein catabolic process, vacuolar acidification	CBF3 complex, RAVE complex, SCF ubiquitin ligase complex, chromosome, centromeric region, condensed chromosome kinetochore, cytoplasm, kinetochore, nucleus	DNA binding, DNA replication origin binding, protein binding, ubiquitin-protein ligase activity		
YDR329C	PEX3	Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p [Source:SGD;Acc:S000002737]	ER-dependent peroxisome organization, peroxisome inheritance, peroxisome organization, protein import into peroxisome membrane	endoplasmic reticulum, integral to membrane, integral to peroxisomal membrane, membrane, peroxisomal membrane, peroxisome	protein binding		
YDR330W	UBX5	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p [Source:SGD;Acc:S000002738]	ubiquitin-dependent protein catabolic process	cytoplasm, nucleus	molecular_function, protein binding		
YDR331W	GPI8	ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog [Source:SGD;Acc:S000002739]	GPI anchor biosynthetic process, attachment of GPI anchor to protein, proteolysis	GPI-anchor transamidase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	GPI-anchor transamidase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity		
YDR332W	IRC3	Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion [Source:SGD;Acc:S000002740]	biological_process	mitochondrion	ATP binding, ATP-dependent RNA helicase activity, DNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YDR333C	YDR333C	Putative protein of unknown function [Source:SGD;Acc:S000002741]	biological_process	cytoplasm	molecular_function		
YDR334W	SWR1	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A [Source:SGD;Acc:S000002742]	chromatin modification, chromatin remodeling, histone exchange	Swr1 complex, nucleus	ATP binding, DNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, structural molecule activity		
YDR335W	MSN5	Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm [Source:SGD;Acc:S000002743]	protein export from nucleus, tRNA re-export from nucleus	nucleus	binding, importin-alpha export receptor activity, protein binding		
YDR336W	YDR336W	Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene [Source:SGD;Acc:S000002744]	biological_process	cellular_component, intracellular	GTP binding, molecular_function, nucleotide binding		
YDR337W	MRPS28	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000002745]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YDR338C	YDR338C	Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily [Source:SGD;Acc:S000002746]	drug transmembrane transport, transmembrane transport, transport	cellular_component, integral to membrane, membrane	antiporter activity, drug transmembrane transporter activity		
YDR339C	FCF1	Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p [Source:SGD;Acc:S000002747]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus, small-subunit processome	molecular_function		
YDR340W	YDR340W	Putative protein of unknown function [Source:SGD;Acc:S000002748]					
YDR341C	YDR341C	Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002749]	arginyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, arginine-tRNA ligase activity, ligase activity, nucleotide binding		
YDR342C	HXT7	High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels [Source:SGD;Acc:S000002750]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, mitochondrion, plasma membrane, plasma membrane enriched fraction	fructose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, pentose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YDR343C	HXT6	High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3 [Source:SGD;Acc:S000002751]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, mitochondrion, plasma membrane, plasma membrane enriched fraction	fructose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YDR344C	YDR344C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002752]					
YDR345C	HXT3	Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions [Source:SGD;Acc:S000002753]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, plasma membrane	fructose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YDR346C	SVF1	Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000002754]	cellular response to oxidative stress, response to oxidative stress	cytoplasm, nucleus	molecular_function		
YDR347W	MRP1	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein [Source:SGD;Acc:S000002755]	mitochondrial translation, oxidation-reduction process, superoxide metabolic process	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	metal ion binding, structural constituent of ribosome, superoxide dismutase activity		
YDR348C	YDR348C	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate [Source:SGD;Acc:S000002756]	biological_process	cellular bud neck, mating projection tip, membrane, plasma membrane	molecular_function		
YDR349C	YPS7	Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum [Source:SGD;Acc:S000002757]	fungal-type cell wall organization, proteolysis	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	aspartic-type endopeptidase activity, hydrolase activity, peptidase activity		
YDR350C	ATP22	Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane [Source:SGD;Acc:S000002758]	positive regulation of mitochondrial translation, protein complex assembly, regulation of translation	membrane, mitochondrial inner membrane, mitochondrion	translation regulator activity		
YDR351W	SBE2	Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth [Source:SGD;Acc:S000002759]	cellular cell wall organization, fungal-type cell wall organization, protein transport, transport	Golgi apparatus	molecular_function		
YDR352W	YDR352W	Putative protein of unknown function [Source:SGD;Acc:S000002760]	biological_process	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YDR353W	TRR1	Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress [Source:SGD;Acc:S000002761]	cell redox homeostasis, cellular response to oxidative stress, oxidation-reduction process, removal of superoxide radicals	cytoplasm, cytosol	ferrous iron binding, flavin adenine dinucleotide binding, oxidoreductase activity, thioredoxin-disulfide reductase activity		
YDR354C-A	YDR354C-A	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps TRP4; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028613]					
YDR354W	TRP4	Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis [Source:SGD;Acc:S000002762]	aromatic amino acid family biosynthetic process, cellular amino acid biosynthetic process, metabolic process, tryptophan biosynthetic process	cytoplasm, nucleus	anthranilate phosphoribosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YDR355C	YDR355C	Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W [Source:SGD;Acc:S000002763]					
YDR356W	SPC110	Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner [Source:SGD;Acc:S000002764]	karyogamy involved in conjugation with cellular fusion, microtubule nucleation	central plaque of spindle pole body, inner plaque of spindle pole body, nucleus	structural constituent of cytoskeleton		
YDR357C	CNL1	Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000002765]	biological_process	cytoplasm	molecular_function		
YDR358W	GGA1	Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi [Source:SGD;Acc:S000002766]	Golgi to endosome transport, Golgi to vacuole transport, intracellular protein transport, protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, protein transport, transport, vesicle-mediated transport	Golgi apparatus, Golgi apparatus part, clathrin adaptor complex, intracellular, membrane coat, trans-Golgi network	ubiquitin binding		
YDR359C	EAF1	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 [Source:SGD;Acc:S000002767]	DNA repair, cellular protein complex assembly, chromatin modification, response to DNA damage stimulus	NuA4 histone acetyltransferase complex, histone acetyltransferase complex, nucleus	DNA binding, molecular_function, protein binding		
YDR360W	OPI7	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. [Source:SGD;Acc:S000002768]					
YDR361C	BCP1	Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport [Source:SGD;Acc:S000002769]	protein export from nucleus, protein transport, ribosomal large subunit export from nucleus, transport	cytoplasm, nucleus	molecular_function		
YDR362C	TFC6	One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 [Source:SGD;Acc:S000002770]	transcription initiation from RNA polymerase III promoter	nucleus, transcription factor TFIIIC complex	DNA binding, protein binding		
YDR363W	ESC2	Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member [Source:SGD;Acc:S000002771]	chromatin silencing at silent mating-type cassette, double-strand break repair via homologous recombination, intra-S DNA damage checkpoint, mitotic sister chromatid cohesion	cytoplasm, nucleus	molecular_function		
YDR363W-A	SEM1	Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1 [Source:SGD;Acc:S000007235]	exocytosis, filamentous growth, mRNA export from nucleus, proteasomal ubiquitin-dependent protein catabolic process, proteasome assembly, regulation of cell cycle, ubiquitin-dependent protein catabolic process	cytosol, microsome, nucleus, proteasome complex, proteasome regulatory particle, lid subcomplex, proteasome storage granule	molecular_function		
YDR364C	CDC40	Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats [Source:SGD;Acc:S000002772]	G1/S transition of mitotic cell cycle, RNA splicing, cell cycle, cell division, generation of catalytic spliceosome for second transesterification step, mRNA processing, nuclear mRNA 3'-splice site recognition, nuclear mRNA branch site recognition	nucleus, spliceosomal complex	protein binding, second spliceosomal transesterification activity		
YDR365C	ESF1	Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels [Source:SGD;Acc:S000002773]	rRNA processing, ribosome biogenesis	nucleolus, nucleus	RNA binding		
YDR365W-A	YDR365W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007400]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YDR365W-B	YDR365W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007401]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YDR366C	YDR366C	Putative protein of unknown function [Source:SGD;Acc:S000002774]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YDR367W	KEI1	Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene [Source:SGD;Acc:S000002775]	inositol phosphorylceramide metabolic process	Golgi apparatus, Golgi membrane, cytoplasm, inositol phosphoceramide synthase complex, integral to Golgi membrane, integral to membrane, membrane	inositol phosphoceramide synthase regulator activity		
YDR368W	YPR1	NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases [Source:SGD;Acc:S000002776]	D-xylose catabolic process, arabinose catabolic process, cellular response to oxidative stress, oxidation-reduction process	cytoplasm, nucleus	alditol:NADP+ 1-oxidoreductase activity, carbonyl reductase (NADPH) activity, glucose 1-dehydrogenase (NADP+) activity, oxidoreductase activity		
YDR369C	XRS2	Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling [Source:SGD;Acc:S000002777]	DNA repair, base-excision repair, double-strand break repair via break-induced replication, double-strand break repair via nonhomologous end joining, meiosis, meiotic DNA double-strand break formation, response to DNA damage stimulus, sporulation resulting in formation of a cellular spore, telomere maintenance	Mre11 complex, nucleus	DNA binding, G-quadruplex DNA binding, double-stranded telomeric DNA binding, protein binding, protein binding, bridging, single-stranded telomeric DNA binding, telomeric DNA binding		
YDR370C	YDR370C	Putative protein of unknown function [Source:SGD;Acc:S000002778]	biological_process	cytoplasm	molecular_function		
YDR371C-A	YDR371C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completeley overlaps the uncharacterized gene CTS2/YDR371W; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028822]					
YDR371W	CTS2	Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect [Source:SGD;Acc:S000002779]	carbohydrate metabolic process, chitin catabolic process, metabolic process, polysaccharide catabolic process, sporulation resulting in formation of a cellular spore	cytoplasm, extracellular region	catalytic activity, cation binding, chitinase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, molecular_function		
YDR372C	VPS74	Protein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; binding to PtdIns4P required for Golgi targeting and function; tetramer formation required for function [Source:SGD;Acc:S000002780]	endoplasmic reticulum unfolded protein response, protein localization in Golgi apparatus, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport	Golgi apparatus, cytoplasm, cytosol, extrinsic to membrane, nucleus	enzyme binding, phosphatidylinositol-4-phosphate binding		
YDR373W	FRQ1	N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily [Source:SGD;Acc:S000002781]	regulation of signal transduction	Golgi membrane, cellular bud membrane, membrane, plasma membrane	calcium ion binding, enzyme activator activity		
YDR374C	YDR374C	Putative protein of unknown function [Source:SGD;Acc:S000002782]	biological_process	cellular_component	molecular_function		
YDR374W-A	YDR374W-A	Putative protein of unknown function [Source:SGD;Acc:S000113553]	biological_process	cellular_component	molecular_function		
YDR375C	BCS1	Mitochondrial protein of the AAA ATPase family; has ATP-dependent chaperone activity; required for assembly of Rip1p and Qcr10p into cytochrome bc(1) complex; mutations in human homolog BCS1L are linked to neonatal mitochondrial diseases [Source:SGD;Acc:S000002783]	aerobic respiration, chaperone-mediated protein complex assembly, mitochondrion organization	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding		
YDR376W	ARH1	Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability [Source:SGD;Acc:S000002784]	cellular iron ion homeostasis, electron transport chain, metabolic process, oxidation-reduction process, transport, ubiquinone biosynthetic process	mitochondrial inner membrane, mitochondrial matrix, mitochondrion	NADPH-adrenodoxin reductase activity, binding, catalytic activity, ferredoxin-NADP+ reductase activity, oxidoreductase activity		
YDR377W	ATP17	Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis [Source:SGD;Acc:S000002785]	ATP biosynthetic process, ATP synthesis coupled proton transport, ion transport, proton transport, transport	membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrion, proton-transporting ATP synthase complex, coupling factor F(o)	ATPase activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism		
YDR378C	LSM6	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000002786]	RNA splicing, mRNA processing, maturation of SSU-rRNA, nuclear mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, rRNA processing, tRNA processing	U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, cytoplasmic mRNA processing body, nucleolus, nucleus, ribonucleoprotein complex, small nucleolar ribonucleoprotein complex	RNA binding		
YDR379C-A	YDR379C-A	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy [Source:SGD;Acc:S000007605]	mitochondrial respiratory chain complex II assembly	mitochondrion	molecular_function		
YDR379W	RGA2	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p [Source:SGD;Acc:S000002787]	actin filament organization, budding cell apical bud growth, budding cell isotropic bud growth, establishment of cell polarity, invasive growth in response to glucose limitation, pheromone-dependent signal transduction involved in conjugation with cellular fusion, pseudohyphal growth, signal transduction, small GTPase mediated signal transduction	cellular bud neck split septin rings, intracellular	GTPase activator activity, Rho GTPase activator activity, metal ion binding, zinc ion binding		
YDR380W	ARO10	Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway [Source:SGD;Acc:S000002788]	L-phenylalanine catabolic process, aromatic amino acid family catabolic process to alcohol via Ehrlich pathway, branched chain family amino acid catabolic process, branched chain family amino acid catabolic process to alcohol via Ehrlich pathway, leucine catabolic process, methionine catabolic process to 3-methylthiopropanol, tryptophan catabolic process, tyrosine catabolic process	cytoplasm	carboxy-lyase activity, catalytic activity, lyase activity, magnesium ion binding, metal ion binding, phenylpyruvate decarboxylase activity, pyruvate decarboxylase activity, thiamine pyrophosphate binding		
YDR381C-A	YDR381C-A	Protein of unknown function, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000007650]	biological_process	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YDR381W	YRA1	RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member [Source:SGD;Acc:S000002789]	mRNA export from nucleus, transcription-coupled nucleotide-excision repair	nucleus, transcription export complex	RNA binding, nucleic acid binding, nucleotide binding		
YDR382W	RPP2B	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm [Source:SGD;Acc:S000002790]	translation, translational elongation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDR383C	NKP1	Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) [Source:SGD;Acc:S000002791]	biological_process, cell cycle, cell division, meiosis, mitosis	chromosome, centromeric region, condensed chromosome kinetochore, kinetochore, nucleus	molecular_function		
YDR384C	ATO3	Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters [Source:SGD;Acc:S000002792]	ammonium transport, ion transport, nitrogen utilization, transmembrane transport, transport	integral to membrane, membrane, mitochondrion, plasma membrane	ammonium transmembrane transporter activity		
YDR385W	EFT2	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin [Source:SGD;Acc:S000002793]	positive regulation of translational elongation, translation, translational elongation	cytoplasm, ribosome	GTP binding, GTPase activity, RNA binding, nucleotide binding, rRNA binding, translation elongation factor activity		
YDR386W	MUS81	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein [Source:SGD;Acc:S000002794]	DNA metabolic process, DNA recombination, DNA repair, DNA topological change, meiosis, reciprocal meiotic recombination, resolution of meiotic recombination intermediates, response to DNA damage stimulus	Holliday junction resolvase complex, nucleus	DNA binding, catalytic activity, crossover junction endodeoxyribonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity		
YDR387C	YDR387C	Putative transporter, member of the sugar porter family; YDR387C is not an essential gene [Source:SGD;Acc:S000002795]	carbohydrate transport, transmembrane transport, transport	integral to membrane, membrane	substrate-specific transmembrane transporter activity, transporter activity		
YDR388W	RVS167	Actin-associated protein, interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin [Source:SGD;Acc:S000002796]	actin cortical patch localization, endocytosis, lipid tube assembly, vesicle-mediated transport	actin cortical patch, cytoplasm, cytoskeleton, mating projection tip	actin binding, cytoskeletal protein binding, lipid binding, protein binding		
YDR389W	SAC7	GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate [Source:SGD;Acc:S000002797]	actin filament reorganization involved in cell cycle, signal transduction, small GTPase mediated signal transduction	cytoplasm, cytoskeleton, intracellular	GTPase activator activity, Rho GTPase activator activity		
YDR390C	UBA2	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability [Source:SGD;Acc:S000002798]	metabolic process, protein modification process, protein sumoylation	SUMO activating enzyme complex, nucleus	ATP binding, SUMO activating enzyme activity, binding, catalytic activity, ligase activity, metal ion binding, nucleotide binding, small protein activating enzyme activity		
YDR391C	YDR391C	Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000002799]	biological_process	cytoplasm, nucleus	molecular_function		
YDR392W	SPT3	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters [Source:SGD;Acc:S000002800]	ascospore formation, chromatin modification, conjugation with cellular fusion, histone acetylation, invasive growth in response to glucose limitation, pseudohyphal growth, transcription from RNA polymerase II promoter	SAGA complex, SLIK (SAGA-like) complex, nucleus	DNA binding, transcription cofactor activity		
YDR393W	SHE9	Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex [Source:SGD;Acc:S000002801]	inner mitochondrial membrane organization, mitochondrion organization	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YDR394W	RPT3	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B [Source:SGD;Acc:S000002802]	proteasome regulatory particle assembly, protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus, proteasome complex, proteasome regulatory particle, base subcomplex	ATP binding, ATPase activity, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding		
YDR395W	SXM1	Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1 [Source:SGD;Acc:S000002803]	intracellular protein transport, mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein transport, transmembrane transport, transport	cytoplasm, nuclear pore, nucleus	binding, protein transporter activity		
YDR396W	YDR396W	Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex [Source:SGD;Acc:S000002804]					
YDR397C	NCB2	Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta [Source:SGD;Acc:S000002805]	negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter	intracellular, negative cofactor 2 complex, nucleus	DNA binding, sequence-specific DNA binding, transcription coactivator activity, transcription corepressor activity		
YDR398W	UTP5	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit [Source:SGD;Acc:S000002806]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of transcription from RNA polymerase I promoter, rRNA processing, ribosome biogenesis	nucleolus, nucleus, rDNA heterochromatin, ribonucleoprotein complex, small-subunit processome, t-UTP complex	molecular_function, protein binding		
YDR399W	HPT1	Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome [Source:SGD;Acc:S000002807]	GMP salvage, IMP salvage, nucleoside metabolic process, purine ribonucleoside salvage	cytoplasm, nucleus	hypoxanthine phosphoribosyltransferase activity, metal ion binding, transferase activity, transferase activity, transferring glycosyl groups		
YDR400W	URH1	Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways [Source:SGD;Acc:S000002808]	ER-associated protein catabolic process, NAD biosynthesis via nicotinamide riboside salvage pathway, metabolic process, nicotinate nucleotide salvage, pyrimidine nucleoside catabolic process, pyrimidine-containing compound salvage	cytoplasm, nucleus	hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing N-glycosyl compounds, nicotinamide riboside hydrolase activity, nicotinic acid riboside hydrolase activity, ribosylpyrimidine nucleosidase activity, uridine nucleosidase activity		
YDR401W	YDR401W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002809]					
YDR402C	DIT2	N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s [Source:SGD;Acc:S000002810]	ascospore wall assembly, oxidation-reduction process, sporulation resulting in formation of a cellular spore	cellular_component	electron carrier activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity		
YDR403W	DIT1	Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure [Source:SGD;Acc:S000002811]	ascospore wall assembly, sporulation resulting in formation of a cellular spore	cellular_component	catalytic activity		
YDR404C	RPB7	RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions [Source:SGD;Acc:S000002812]	nuclear-transcribed mRNA catabolic process, exonucleolytic, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex, cytoplasm, cytoplasmic mRNA processing body, nucleus	DNA-directed RNA polymerase activity, RNA binding, single-stranded DNA binding, single-stranded RNA binding		
YDR405W	MRP20	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000002813]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDR406W	PDR15	Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element [Source:SGD;Acc:S000002814]	response to drug, transport	integral to membrane, membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YDR406W-A	YDR406W-A	Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028543]					
YDR407C	TRS120	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic [Source:SGD;Acc:S000002815]	early endosome to Golgi transport, intra-Golgi vesicle-mediated transport, regulation of Rab GTPase activity, transport	Golgi apparatus, TRAPP complex, early endosome, trans-Golgi network	Rab guanyl-nucleotide exchange factor activity		
YDR408C	ADE8	Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway [Source:SGD;Acc:S000002816]	'de novo' IMP biosynthetic process, adenine biosynthetic process, biosynthetic process, purine nucleotide biosynthetic process	cytoplasm, nucleus	hydroxymethyl-, formyl- and related transferase activity, methyltransferase activity, phosphoribosylglycinamide formyltransferase activity, transferase activity		
YDR409W	SIZ1	SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring [Source:SGD;Acc:S000002817]	chromosome segregation, protein sumoylation	cellular bud neck, cytoplasm, cytosol, nuclear chromatin, nucleus, septin ring	SUMO ligase activity, ligase activity, metal ion binding, nucleic acid binding, zinc ion binding		
YDR410C	STE14	Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane [Source:SGD;Acc:S000002818]	C-terminal protein methylation, peptide pheromone maturation, response to pheromone	endoplasmic reticulum membrane, integral to membrane, membrane, nuclear inner membrane	methyltransferase activity, protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity, transferase activity		
YDR411C	DFM1	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p [Source:SGD;Acc:S000002819]	ER-associated protein catabolic process, endoplasmic reticulum unfolded protein response, response to stress	Doa10p ubiquitin ligase complex, Hrd1p ubiquitin ligase ERAD-L complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YDR412W	RRP17	Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5&#8242; end processing of pre-60S ribosomal RNA [Source:SGD;Acc:S000002820]	rRNA processing, ribosome biogenesis	cytoplasm, nucleolus, nucleus	molecular_function		
YDR413C	YDR413C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing [Source:SGD;Acc:S000002821]					
YDR414C	ERD1	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) [Source:SGD;Acc:S000002822]	protein glycosylation, protein retention in ER lumen, protein transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YDR415C	YDR415C	Putative protein of unknown function [Source:SGD;Acc:S000002823]	biological_process, proteolysis	cellular_component	aminopeptidase activity, hydrolase activity, metal ion binding, molecular_function, peptidase activity		
YDR416W	SYF1	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans [Source:SGD;Acc:S000002824]	RNA processing, RNA splicing, cell cycle, generation of catalytic spliceosome for first transesterification step, mRNA processing	Prp19 complex, U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, U2-type post-mRNA release spliceosomal complex, U2-type prespliceosome, intracellular, nucleus, spliceosomal complex	binding, first spliceosomal transesterification activity, second spliceosomal transesterification activity		
YDR417C	YDR417C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W [Source:SGD;Acc:S000002825]					
YDR418W	RPL12B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins [Source:SGD;Acc:S000002826]	ribosomal large subunit assembly, translation	cytoplasm, cytosolic large ribosomal subunit, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YDR419W	RAD30	DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; mutations in human pol eta are responsible for XPV [Source:SGD;Acc:S000002827]	DNA repair, DNA replication, error-free translesion synthesis, error-prone translesion synthesis, response to DNA damage stimulus	nucleus, replication fork	DNA binding, DNA-directed DNA polymerase activity, damaged DNA binding, metal ion binding, nucleotidyltransferase activity, transferase activity		
YDR420W	HKR1	Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection [Source:SGD;Acc:S000002828]	1,3-beta-D-glucan biosynthetic process, cellular bud site selection, fungal-type cell wall organization, hyperosmotic response, osmosensory signaling pathway via Sho1 osmosensor	integral to membrane, membrane, plasma membrane, site of polarized growth	osmosensor activity		
YDR421W	ARO80	Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids [Source:SGD;Acc:S000002829]	L-phenylalanine catabolic process, aromatic amino acid family catabolic process, branched chain family amino acid catabolic process, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, tryptophan catabolic process, tyrosine catabolic process	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YDR422C	SIP1	Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions [Source:SGD;Acc:S000002830]	protein phosphorylation, regulation of protein complex assembly, signal transduction	AMP-activated protein kinase complex, cytoplasm, fungal-type vacuole, membrane, vacuolar membrane, vacuole	AMP-activated protein kinase activity		
YDR423C	CAD1	AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA [Source:SGD;Acc:S000002831]	positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to cadmium ion	cytoplasm, nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YDR424C	DYN2	Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex [Source:SGD;Acc:S000002832]	actin filament-based process, microtubule-based process, nuclear pore complex assembly, transport	cytoplasm, cytoplasmic dynein complex, cytoplasmic microtubule, cytoskeleton, dynein complex, microtubule, microtubule associated complex, nuclear pore, peroxisome	microtubule motor activity, molecular_function, motor activity		
YDR425W	SNX41	Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p [Source:SGD;Acc:S000002833]	cell communication, protein transport, retrograde transport, endosome to Golgi, transport	endosome, late endosome	phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding		
YDR426C	YDR426C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41 [Source:SGD;Acc:S000002834]					
YDR427W	RPN9	Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects [Source:SGD;Acc:S000002835]	proteasome assembly, ubiquitin-dependent protein catabolic process	proteasome complex, proteasome regulatory particle, lid subcomplex, proteasome storage granule	protein binding, structural molecule activity		
YDR428C	BNA7	Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine [Source:SGD;Acc:S000002836]	NAD biosynthetic process, tryptophan catabolic process	cellular_component	arylformamidase activity, hydrolase activity		
YDR429C	TIF35	eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation [Source:SGD;Acc:S000002837]	translation, translational initiation	cytoplasm, eukaryotic translation initiation factor 3 complex	RNA binding, nucleic acid binding, nucleotide binding, translation initiation factor activity		
YDR430C	CYM1	Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology [Source:SGD;Acc:S000002838]	proteolysis, proteolysis involved in cellular protein catabolic process	mitochondrial intermembrane space, mitochondrion	catalytic activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding		
YDR431W	YDR431W	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002839]					
YDR432W	NPL3	RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm [Source:SGD;Acc:S000002840]	mRNA export from nucleus, nuclear mRNA splicing, via spliceosome, positive regulation of transcription elongation, DNA-dependent, pseudohyphal growth, rRNA processing, regulation of transcription termination, DNA-dependent, ribosome biogenesis, translational termination	cytoplasm, nucleolus, nucleus, ribonucleoprotein complex	RNA binding, mRNA binding, nucleic acid binding, nucleotide binding, poly(A) RNA binding		
YDR433W	YDR433W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002841]					
YDR434W	GPI17	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog [Source:SGD;Acc:S000002842]	GPI anchor biosynthetic process, attachment of GPI anchor to protein	GPI-anchor transamidase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	GPI-anchor transamidase activity		
YDR435C	PPM1	Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits [Source:SGD;Acc:S000002843]	C-terminal protein methylation, cellular protein complex assembly	cellular_component	methyltransferase activity, protein C-terminal leucine carboxyl O-methyltransferase activity, transferase activity		
YDR436W	PPZ2	Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance [Source:SGD;Acc:S000002844]	cellular sodium ion homeostasis	cellular_component	cofactor binding, hydrolase activity, magnesium-dependent protein serine/threonine phosphatase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YDR437W	GPI19	Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P [Source:SGD;Acc:S000002845]	GPI anchor biosynthetic process, cellular cell wall organization	endoplasmic reticulum, endoplasmic reticulum membrane, glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, integral to endoplasmic reticulum membrane, integral to membrane, membrane, nuclear envelope	UDP-glycosyltransferase activity, phosphatidylinositol N-acetylglucosaminyltransferase activity, transferase activity		
YDR438W	THI74	Mitochondrial transporter repressible by thiamine [Source:SGD;Acc:S000002846]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YDR439W	LRS4	Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation [Source:SGD;Acc:S000002847]	cell cycle, chromatin silencing at rDNA, homologous chromosome segregation, meiosis, protein localization to nucleolar rDNA repeats, rDNA condensation	chromosome, centromeric region, monopolin complex, nucleolus, nucleus	molecular_function		
YDR440W	DOT1	Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response [Source:SGD;Acc:S000002848]	DNA damage checkpoint, chromatin modification, chromatin silencing at telomere, histone H3-K79 methylation, meiotic recombination checkpoint, nucleotide-excision repair, postreplication repair, recombinational repair	nucleus	DNA binding, histone methyltransferase activity (H3-K79 specific), histone-lysine N-methyltransferase activity, methyltransferase activity, nucleosomal histone binding, transferase activity		
YDR441C	APT2	Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity [Source:SGD;Acc:S000002849]	adenine salvage, biological_process, nucleoside metabolic process, purine ribonucleoside salvage	cytoplasm	adenine phosphoribosyltransferase activity, molecular_function, transferase activity, transferase activity, transferring glycosyl groups		
YDR442W	YDR442W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002850]					
YDR443C	SSN2	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation [Source:SGD;Acc:S000002851]	negative regulation of transcription from RNA polymerase II promoter, nuclear-transcribed mRNA catabolic process, non-stop decay, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter by galactose, regulation of transcription from RNA polymerase II promoter	integral to membrane, mediator complex, nucleus			
YDR444W	YDR444W	Putative protein of unknown function [Source:SGD;Acc:S000002852]	biological_process, lipid catabolic process, lipid metabolic process	cytoplasm	hydrolase activity, hydrolase activity, acting on ester bonds, molecular_function		
YDR445C	YDR445C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002853]					
YDR446W	ECM11	Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure [Source:SGD;Acc:S000002854]	cellular cell wall organization, fungal-type cell wall organization, reciprocal meiotic recombination	nucleus	molecular_function		
YDR447C	RPS17B	Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein [Source:SGD;Acc:S000002855]	ribosomal small subunit assembly, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDR448W	ADA2	Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes [Source:SGD;Acc:S000002856]	chromatin modification, chromatin silencing at rDNA, chromatin silencing at telomere, positive regulation of histone acetylation, regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex, SAGA complex, SLIK (SAGA-like) complex, nucleus	DNA binding, chromatin binding, histone acetyltransferase activity, metal ion binding, phosphatidylserine binding, protein binding, transcription coactivator activity, zinc ion binding		
YDR449C	UTP6	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000002857]	RNA processing, endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, Pwp2p-containing subcomplex of 90S preribosome, intracellular, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	binding, snoRNA binding		
YDR450W	RPS18A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins [Source:SGD;Acc:S000002858]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA export from nucleus, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, nucleic acid binding, rRNA binding, structural constituent of ribosome		
YDR451C	YHP1	One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval [Source:SGD;Acc:S000002859]	cell cycle, negative regulation of transcription from RNA polymerase II promoter, regulation of meiosis, regulation of mitotic cell cycle, regulation of transcription, DNA-dependent	nuclear chromatin, nuclear chromosome, nucleus	DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YDR452W	PPN1	Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer [Source:SGD;Acc:S000002860]	polyphosphate catabolic process, polyphosphate metabolic process	integral to membrane, membrane, nucleus, vacuolar membrane, vacuole	endopolyphosphatase activity, exopolyphosphatase activity, hydrolase activity, metal ion binding		
YDR453C	TSA2	Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants [Source:SGD;Acc:S000002861]	cell redox homeostasis, cellular response to oxidative stress, oxidation-reduction process	cytoplasm	antioxidant activity, oxidoreductase activity, peroxidase activity, peroxiredoxin activity, thioredoxin peroxidase activity		
YDR454C	GUK1	Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins [Source:SGD;Acc:S000002862]	GMP metabolic process, purine nucleotide metabolic process	cytoplasm, nucleus	ATP binding, guanylate kinase activity, kinase activity, nucleotide binding, protein binding, transferase activity		
YDR455C	YDR455C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W [Source:SGD;Acc:S000002863]					
YDR456W	NHX1	Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion [Source:SGD;Acc:S000002864]	cation transport, cellular monovalent inorganic cation homeostasis, ion transport, monovalent inorganic cation transport, potassium ion transport, regulation of pH, sodium ion transport, transmembrane transport, transport, vacuolar acidification	endosome, endosome membrane, fungal-type vacuole membrane, integral to membrane, late endosome, late endosome membrane, membrane	antiporter activity, monovalent inorganic cation transmembrane transporter activity, sodium:hydrogen antiporter activity, solute:hydrogen antiporter activity		
YDR457W	TOM1	E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones [Source:SGD;Acc:S000002865]	cell cycle, cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), mRNA transport, mitosis, nucleocytoplasmic transport, nucleus organization, protein modification process, protein ubiquitination, rRNA processing, regulation of cell size, transport	intracellular, nucleolus, nucleus	acid-amino acid ligase activity, binding, ligase activity, ubiquitin-protein ligase activity		
YDR458C	HEH2	Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle [Source:SGD;Acc:S000002866]	biological_process	integral to membrane, membrane, nuclear envelope, nuclear inner membrane, nucleus	molecular_function		
YDR459C	PFA5	Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain [Source:SGD;Acc:S000002867]	protein palmitoylation	integral to membrane, membrane, plasma membrane	acyltransferase activity, metal ion binding, protein-cysteine S-palmitoleyltransferase activity, transferase activity, zinc ion binding		
YDR460W	TFB3	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit [Source:SGD;Acc:S000002868]	cell cycle, nucleotide-excision repair, phosphorylation of RNA polymerase II C-terminal domain	TFIIK complex, holo TFIIH complex, nucleus	metal ion binding, protein binding, zinc ion binding		
YDR461C-A	YDR461C-A	Putative protein of unknown function [Source:SGD;Acc:S000087209]	biological_process	cellular_component	molecular_function		
YDR461W	MFA1	Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 [Source:SGD;Acc:S000002869]	pheromone-dependent signal transduction involved in conjugation with cellular fusion	extracellular region, membrane, plasma membrane, soluble fraction	mating pheromone activity, pheromone activity		
YDR462W	MRPL28	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000002870]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDR463W	STP1	Transcription factor, undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing [Source:SGD;Acc:S000002871]	positive regulation of transcription from RNA polymerase II promoter, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation	intracellular, membrane, nucleus, plasma membrane	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YDR464C-A	YDR464C-A	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028614]					
YDR464W	SPP41	Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 [Source:SGD;Acc:S000002872]	negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding, molecular_function		
YDR465C	RMT2	Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67 [Source:SGD;Acc:S000002873]	peptidyl-arginine methylation	cytoplasm, nucleus	methyltransferase activity, protein-arginine N5-methyltransferase activity, transferase activity		
YDR466W	PKH3	Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant [Source:SGD;Acc:S000002874]	MAPKKK cascade involved in cell wall biogenesis, protein phosphorylation	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDR467C	YDR467C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002875]					
YDR468C	TLG1	Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p [Source:SGD;Acc:S000002876]	Golgi vesicle transport, intracellular protein transport, protein transport, transport, vesicle fusion, vesicle-mediated transport	Golgi apparatus, Golgi trans cisterna, SNARE complex, early endosome, early endosome membrane, endosome, integral to membrane, late endosome membrane, membrane, trans-Golgi network	SNAP receptor activity, protein binding		
YDR469W	SDC1	Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 [Source:SGD;Acc:S000002877]	chromatin silencing at telomere, histone H3-K4 methylation, regulation of transcription, DNA-dependent	Set1C/COMPASS complex, intracellular, nucleus	histone methyltransferase activity (H3-K4 specific)		
YDR470C	UGO1	Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion [Source:SGD;Acc:S000002878]	filamentous growth, mitochondrial fusion, mitochondrial genome maintenance, transmembrane transport, transport	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	binding, transporter activity		
YDR471W	RPL27B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein [Source:SGD;Acc:S000002879]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDR472W	TRS31	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic [Source:SGD;Acc:S000002880]	ER to Golgi vesicle-mediated transport, cGMP biosynthetic process, transport, vesicle-mediated transport	Golgi apparatus, TRAPP complex, endoplasmic reticulum	Rab guanyl-nucleotide exchange factor activity, guanylate cyclase activity, heme binding		
YDR473C	PRP3	Splicing factor, component of the U4/U6-U5 snRNP complex [Source:SGD;Acc:S000002881]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U4/U6 x U5 tri-snRNP complex, nucleus, spliceosomal complex	molecular_function		
YDR475C	JIP4	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence [Source:SGD;Acc:S000002883]	biological_process	cellular_component	molecular_function		
YDR476C	YDR476C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene [Source:SGD;Acc:S000002884]	biological_process	endoplasmic reticulum	molecular_function		
YDR477W	SNF1	AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis [Source:SGD;Acc:S000002885]	biofilm formation, carbohydrate metabolic process, cell adhesion, cellular response to nitrogen starvation, invasive growth in response to glucose limitation, negative regulation of translation, positive regulation of gluconeogenesis, protein phosphorylation, pseudohyphal growth, regulation of carbohydrate metabolic process, replicative cell aging, signal transduction	AMP-activated protein kinase complex, cytoplasm, fungal-type vacuole, membrane, mitochondrion, nuclear envelope lumen, nuclear membrane, nucleus	AMP-activated protein kinase activity, ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDR478W	SNM1	Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP [Source:SGD;Acc:S000002886]	mRNA cleavage, rRNA processing	nucleus, ribonuclease MRP complex	RNA binding, hydrolase activity, nuclease activity, ribonuclease MRP activity		
YDR479C	PEX29	Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p [Source:SGD;Acc:S000002887]	peroxisome organization	integral to membrane, membrane, peroxisomal membrane, peroxisome	molecular_function		
YDR480W	DIG2	MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p [Source:SGD;Acc:S000002888]	negative regulation of invasive growth in response to glucose limitation, negative regulation of pseudohyphal growth, negative regulation of transcription from RNA polymerase II promoter by pheromones	nucleus	transcription factor binding		
YDR481C	PHO8	Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides [Source:SGD;Acc:S000002889]	metabolic process, protein dephosphorylation	cytoplasm, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	alkaline phosphatase activity, catalytic activity, hydrolase activity, metal ion binding, phosphatase activity		
YDR482C	CWC21	Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p [Source:SGD;Acc:S000002890]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U2-type spliceosomal complex, cytoplasm, nucleus, spliceosomal complex	molecular_function		
YDR483W	KRE2	Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation [Source:SGD;Acc:S000002891]	N-glycan processing, cell wall mannoprotein biosynthetic process, protein O-linked glycosylation, protein glycosylation	Golgi apparatus, Golgi membrane, integral to membrane, membrane	alpha-1,2-mannosyltransferase activity, glycolipid 2-alpha-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YDR484W	VPS52	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin [Source:SGD;Acc:S000002892]	Golgi to vacuole transport, actin filament-based process, protein transport, retrograde transport, endosome to Golgi, transport	GARP complex, Golgi apparatus, cytoplasm, cytoskeleton, endosome, endosome membrane, membrane	protein binding		
YDR485C	VPS72	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting [Source:SGD;Acc:S000002893]	chromatin modification, chromatin remodeling, histone exchange	Swr1 complex, cytoplasm, nucleus	DNA binding, histone binding, sequence-specific DNA binding transcription factor activity		
YDR486C	VPS60	Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p [Source:SGD;Acc:S000002894]	filamentous growth, late endosome to vacuole transport via multivesicular body sorting pathway, protein transport, transport	cytoplasm, endosome, endosome membrane, fungal-type vacuole membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YDR487C	RIB3	3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration [Source:SGD;Acc:S000002895]	aerobic respiration, riboflavin biosynthetic process	cytosol, mitochondrial intermembrane space	3,4-dihydroxy-2-butanone-4-phosphate synthase activity, lyase activity, metal ion binding		
YDR488C	PAC11	Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8 [Source:SGD;Acc:S000002896]	microtubule-based process, nuclear migration along microtubule	cytoplasm, cytoplasmic dynein complex, cytoplasmic microtubule, cytoskeleton, microtubule	microtubule motor activity, plus-end-directed microtubule motor activity, protein binding		
YDR489W	SLD5	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery [Source:SGD;Acc:S000002897]	DNA replication, DNA-dependent DNA replication, double-strand break repair via break-induced replication	DNA replication preinitiation complex, GINS complex, nucleus, replication fork protection complex	molecular_function		
YDR490C	PKH1	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p [Source:SGD;Acc:S000002898]	MAPKKK cascade involved in cell wall biogenesis, cytoplasmic mRNA processing body assembly, endocytosis, protein phosphorylation, regulation of nuclear-transcribed mRNA poly(A) tail shortening	cell cortex, cytosol	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDR491C	YDR491C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002899]					
YDR492W	IZH1	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc [Source:SGD;Acc:S000002900]	cellular lipid metabolic process, cellular zinc ion homeostasis, response to zinc ion	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	metal ion binding		
YDR493W	MZM1	Mitochondrial matrix protein with a role in maintaining the labile mitochondrial zinc pool; null mutant has a respiratory growth defect and an elevated frequency of mitochondrial genome loss; overexpression causes cell cycle delay or arrest [Source:SGD;Acc:S000002901]	cellular zinc ion homeostasis	mitochondrial matrix, mitochondrion	molecular_function		
YDR494W	RSM28	Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation [Source:SGD;Acc:S000002902]	translation, translational initiation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YDR495C	VPS3	Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase [Source:SGD;Acc:S000002903]	protein targeting to vacuole, vacuolar acidification, vacuole inheritance	CORVET complex, cytoplasm	molecular_function, small GTPase regulator activity		
YDR496C	PUF6	Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis [Source:SGD;Acc:S000002904]	negative regulation of translation, regulation of translation, ribosomal large subunit biogenesis, transport	cellular bud tip, large ribosomal subunit, nucleolus, nucleus	RNA binding, binding, mRNA 3'-UTR binding, translation repressor activity, nucleic acid binding		
YDR497C	ITR1	Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p [Source:SGD;Acc:S000002905]	myo-inositol transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	myo-inositol transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YDR498C	SEC20	Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p [Source:SGD;Acc:S000002906]	protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle fusion with endoplasmic reticulum, vesicle-mediated transport	SNARE complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, peroxisome	SNAP receptor activity		
YDR499W	LCD1	Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP [Source:SGD;Acc:S000002907]	DNA damage checkpoint, DNA repair, chromatin modification, establishment of protein localization, response to DNA damage stimulus, telomere maintenance via telomerase	cytoplasm, nuclear chromosome, nucleus	damaged DNA binding		
YDR500C	RPL37B	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein [Source:SGD;Acc:S000002908]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, metal ion binding, rRNA binding, structural constituent of ribosome		
YDR501W	PLM2	Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; similar to TOS4 [Source:SGD;Acc:S000002909]	response to DNA damage stimulus	nuclear chromatin, nucleus	chromatin binding, protein binding		
YDR502C	SAM2	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) [Source:SGD;Acc:S000002910]	S-adenosylmethionine biosynthetic process, methionine metabolic process, one-carbon metabolic process	cellular_component	ATP binding, metal ion binding, methionine adenosyltransferase activity, nucleotide binding, transferase activity		
YDR503C	LPP1	Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA [Source:SGD;Acc:S000002911]	phospholipid metabolic process	Golgi apparatus, Golgi membrane, integral to membrane, membrane	catalytic activity, hydrolase activity, phosphatidate phosphatase activity		
YDR504C	SPG3	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources [Source:SGD;Acc:S000002912]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YDR505C	PSP1	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition [Source:SGD;Acc:S000002913]	biological_process	cytoplasm, mitochondrion	molecular_function		
YDR506C	YDR506C	Possible membrane-localized protein [Source:SGD;Acc:S000002914]	biological_process, ion transport, iron ion transport, oxidation-reduction process, transport	cellular_component	copper ion binding, metal ion binding, molecular_function, oxidoreductase activity		
YDR507C	GIN4	Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p [Source:SGD;Acc:S000002915]	budding cell bud growth, protein autophosphorylation, protein phosphorylation, septin checkpoint, septin ring assembly	cellular bud neck, cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDR508C	GNP1	High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids [Source:SGD;Acc:S000002916]	amino acid transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial membrane, mitochondrion, plasma membrane	L-proline transmembrane transporter activity, amino acid transmembrane transporter activity		
YDR509W	YDR509W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002917]					
YDR510C-A	YDR510C-A	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028615]					
YDR510W	SMT3	Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2 [Source:SGD;Acc:S000002918]	protein sumoylation	condensed nuclear chromosome, nucleus, septin ring	protein binding, protein tag		
YDR511W	ACN9	Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes [Source:SGD;Acc:S000002919]	carbon utilization, gluconeogenesis, regulation of gluconeogenesis	mitochondrial intermembrane space, mitochondrion	molecular_function		
YDR512C	EMI1	Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000002920]	ascospore formation, meiosis, mitochondrial respiratory chain complex assembly, positive regulation of transcription from RNA polymerase II promoter, sporulation resulting in formation of a cellular spore	cellular_component	molecular_function		
YDR513W	GRX2	Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress [Source:SGD;Acc:S000002921]	cell redox homeostasis, cellular response to oxidative stress, electron transport chain, transport	cytoplasm, cytosol, mitochondrion	disulfide oxidoreductase activity, electron carrier activity, glutathione peroxidase activity, glutathione transferase activity, protein disulfide oxidoreductase activity		
YDR514C	YDR514C	Putative protein of unknown function [Source:SGD;Acc:S000002922]	biological_process	mitochondrion, nucleus	molecular_function, nucleic acid binding		
YDR515W	SLF1	RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts [Source:SGD;Acc:S000002923]	cellular copper ion homeostasis, regulation of translation	cytoplasm, polysome	RNA binding		
YDR516C	EMI2	Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p [Source:SGD;Acc:S000002924]	ascospore formation, carbohydrate metabolic process, glycolysis, positive regulation of transcription from RNA polymerase II promoter, sporulation resulting in formation of a cellular spore	cytoplasm	ATP binding, glucokinase activity, hexokinase activity, kinase activity, molecular_function, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YDR517W	GRH1	Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes [Source:SGD;Acc:S000002925]	ER to Golgi vesicle-mediated transport, Golgi organization, protein secretion, transport, vesicle-mediated transport	COPII vesicle coat, cis-Golgi network, cytoplasm	molecular_function		
YDR518W	EUG1	Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER [Source:SGD;Acc:S000002926]	cell redox homeostasis, protein folding	endoplasmic reticulum, endoplasmic reticulum lumen	isomerase activity, protein disulfide isomerase activity, protein disulfide oxidoreductase activity		
YDR519W	FPR2	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking [Source:SGD;Acc:S000002927]	biological_process, protein folding	endoplasmic reticulum, endoplasmic reticulum membrane, membrane	FK506 binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity		
YDR520C	URC2	Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism [Source:SGD;Acc:S000002928]	cytosine metabolic process, nucleotide metabolic process, regulation of transcription, DNA-dependent, uracil catabolic process	cytoplasm, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YDR521W	YDR521W	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol [Source:SGD;Acc:S000002929]					
YDR522C	SPS2	Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component [Source:SGD;Acc:S000002930]	ascospore formation, ascospore wall assembly, meiosis, sporulation resulting in formation of a cellular spore	anchored to membrane, fungal-type cell wall, membrane, plasma membrane, plasma membrane enriched fraction	molecular_function		
YDR523C	SPS1	Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis [Source:SGD;Acc:S000002931]	ascospore formation, ascospore wall assembly, meiosis, protein phosphorylation, sporulation resulting in formation of a cellular spore	cytoplasm, nucleus, prospore membrane	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YDR524C	AGE1	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif [Source:SGD;Acc:S000002932]	ER to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, protein transport, regulation of ARF GTPase activity, transport	cytoplasm, endosome, trans-Golgi network	ARF GTPase activator activity, GTPase activator activity, metal ion binding, phospholipid binding, zinc ion binding		
YDR524C-A	YDR524C-A	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028616]					
YDR524C-B	YDR524C-B	Putative protein of unknown function [Source:SGD;Acc:S000028739]	biological_process	anchored to membrane, cellular_component, membrane, plasma membrane	molecular_function		
YDR524W-C	YDR524W-C	Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin [Source:SGD;Acc:S000028740]	biological_process	cellular_component	molecular_function		
YDR525W	API2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology [Source:SGD;Acc:S000002933]					
YDR525W-A	SNA2	Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000007236]	biological_process	cytoplasm, integral to membrane, lipid particle, membrane, vacuolar membrane	molecular_function		
YDR526C	YDR526C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002934]					
YDR527W	RBA50	Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 [Source:SGD;Acc:S000002935]	transcription from RNA polymerase II promoter	cytoplasm	molecular_function		
YDR528W	HLR1	Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A [Source:SGD;Acc:S000002936]	cellular cell wall organization, fungal-type cell wall organization	cytoplasm	molecular_function		
YDR529C	QCR7	Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly [Source:SGD;Acc:S000002937]	aerobic respiration, electron transport chain, mitochondrial electron transport, ubiquinol to cytochrome c, mitochondrial respiratory chain complex III assembly, transport	membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex III, mitochondrion, respiratory chain	ubiquinol-cytochrome-c reductase activity		
YDR530C	APA2	Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p [Source:SGD;Acc:S000002938]	nucleotide metabolic process	cytoplasm, nucleus	ATP adenylyltransferase activity, ATP binding, bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity, bis(5'-nucleosyl)-tetraphosphatase activity, catalytic activity, hydrolase activity, nucleotide binding, nucleotidyltransferase activity, transferase activity		
YDR531W	CAB1	Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA) [Source:SGD;Acc:S000002939]	coenzyme A biosynthetic process	cytoplasm, nucleus	ATP binding, kinase activity, nucleotide binding, pantothenate kinase activity, transferase activity		
YDR532C	KRE28	Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components [Source:SGD;Acc:S000002940]	biological_process	chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, membrane, nuclear membrane, nucleus, spindle pole body	molecular_function		
YDR533C	HSP31	Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site [Source:SGD;Acc:S000002941]	biological_process, response to stress	soluble fraction	cysteine-type peptidase activity, hydrolase activity, peptidase activity, unfolded protein binding		
YDR534C	FIT1	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall [Source:SGD;Acc:S000002942]	ion transport, iron ion transport, siderophore transport, transport	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	ATP binding, molecular_function, nucleotide binding		
YDR535C	YDR535C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. [Source:SGD;Acc:S000002943]					
YDR536W	STL1	Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock [Source:SGD;Acc:S000002944]	carbohydrate transport, glycerol transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	solute:hydrogen symporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YDR537C	YDR537C	Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W [Source:SGD;Acc:S000002945]					
YDR538W	PAD1	Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX [Source:SGD;Acc:S000002946]	aromatic compound catabolic process, cinnamic acid catabolic process	cytoplasm, mitochondrion	carboxy-lyase activity, catalytic activity, lyase activity, mRNA binding		
YDR539W	FDC1	Ferulic acid decarboxylase, essential for decarboxylation of phenylacrylic acids; homolog of E. coli UbiD; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000002947]	biological_process, ubiquinone biosynthetic process	cytoplasm, plasma membrane	carboxy-lyase activity, molecular_function		
YDR540C	IRC4	Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000002948]	mitotic recombination	cytoplasm, nucleus	molecular_function		
YDR541C	YDR541C	Putative dihydrokaempferol 4-reductase [Source:SGD;Acc:S000002949]	biological_process, cellular metabolic process, metabolic process, oxidation-reduction process	cellular_component	binding, carbonyl reductase (NADPH) activity, catalytic activity, coenzyme binding, oxidoreductase activity		
YDR542W	PAU10	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000002950]	biological_process, response to stress	cellular_component	molecular_function		
YDR543C	YDR543C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002951]					
YDR544C	YDR544C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002952]					
YDR545C-A	YDR545C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-1/YDR545W [Source:SGD;Acc:S000028617]					
YDR545W	YRF1-1	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000002953]	telomere maintenance via recombination	nucleus	ATP binding, ATP-dependent helicase activity, DNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YEL001C	IRC22	Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000000727]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YEL002C	WBP1	Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum [Source:SGD;Acc:S000000728]	cell cycle, protein N-linked glycosylation, protein N-linked glycosylation via asparagine	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear envelope, oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YEL003W	GIM4	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it [Source:SGD;Acc:S000000729]	protein folding, tubulin complex assembly	cytoplasm, prefoldin complex	tubulin binding, unfolded protein binding		
YEL004W	YEA4	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER [Source:SGD;Acc:S000000730]	UDP-N-acetylglucosamine transport, UDP-glucose transport, carbohydrate transport, fungal-type cell wall chitin biosynthetic process, nucleotide-sugar transport, transmembrane transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	UDP-N-acetylglucosamine transmembrane transporter activity, nucleotide-sugar transmembrane transporter activity		
YEL005C	VAB2	Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter [Source:SGD;Acc:S000000731]	biological_process	cytoplasm, cytoplasmic membrane-bounded vesicle, cytoplasmic vesicle, vacuole	molecular_function		
YEL006W	YEA6	Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog [Source:SGD;Acc:S000000732]	NAD transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	NAD transporter activity, binding, transporter activity		
YEL007W	YEL007W	Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) [Source:SGD;Acc:S000000733]	biological_process	cytoplasm, nucleus	molecular_function		
YEL008C-A	YEL008C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028618]					
YEL008W	YEL008W	Hypothetical protein predicted to be involved in metabolism [Source:SGD;Acc:S000000734]					
YEL009C	GCN4	Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels [Source:SGD;Acc:S000000735]	cellular amino acid biosynthetic process, establishment of protein localization, positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, positive regulation of transcription initiation from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nucleus	DNA binding, nucleic acid binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YEL009C-A	YEL009C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028741]					
YEL010W	YEL010W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000736]					
YEL011W	GLC3	Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000000737]	carbohydrate metabolic process, glycogen biosynthetic process	cytoplasm	1,4-alpha-glucan branching enzyme activity, catalytic activity, cation binding, hydrolase activity, hydrolyzing O-glycosyl compounds, transferase activity, transferase activity, transferring glycosyl groups		
YEL012W	UBC8	Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro [Source:SGD;Acc:S000000738]	negative regulation of gluconeogenesis, post-translational protein modification, proteasomal ubiquitin-dependent protein catabolic process, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, regulation of protein metabolic process	cytoplasm	ATP binding, acid-amino acid ligase activity, ligase activity, nucleotide binding, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YEL013W	VAC8	Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions [Source:SGD;Acc:S000000739]	CVT vesicle assembly, macroautophagy, nucleus-vacuole junction assembly, piecemeal microautophagy of nucleus, vacuole fusion, non-autophagic, vacuole inheritance	Myo2p-Vac17p-Vac8p transport complex, fungal-type vacuole membrane, membrane, nucleus-vacuole junction, vacuolar membrane, vacuole	binding, protein anchor, protein binding		
YEL014C	YEL014C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000740]					
YEL015W	EDC3	Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies [Source:SGD;Acc:S000000741]	cytoplasmic mRNA processing body assembly, deadenylation-independent decapping of nuclear-transcribed mRNA	cytoplasm, cytoplasmic mRNA processing body	molecular_function		
YEL016C	NPP2	Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation [Source:SGD;Acc:S000000742]	metabolic process, nucleoside triphosphate metabolic process	cellular_component, integral to membrane, membrane	catalytic activity, hydrolase activity, nucleoside-triphosphatase activity, nucleoside-triphosphate diphosphatase activity, nucleotide diphosphatase activity, phosphodiesterase I activity		
YEL017C-A	PMP2	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1 [Source:SGD;Acc:S000002103]	cation transport	integral to membrane, membrane, plasma membrane	molecular_function		
YEL017W	GTT3	Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery [Source:SGD;Acc:S000000743]	biological_process	cellular_component, integral to membrane, membrane, nuclear membrane, nucleus	molecular_function		
YEL018C-A	YEL018C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028742]					
YEL018W	EAF5	Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex [Source:SGD;Acc:S000000744]	DNA repair, chromatin modification, response to DNA damage stimulus	NuA4 histone acetyltransferase complex, nucleus	molecular_function		
YEL019C	MMS21	SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination [Source:SGD;Acc:S000000745]	DNA recombination, DNA repair, response to DNA damage stimulus	Smc5-Smc6 complex, cytoplasm, nuclear envelope, nucleus	SUMO ligase activity, ligase activity, metal ion binding, zinc ion binding		
YEL020C	YEL020C	Hypothetical protein with low sequence identity to Pdc1p [Source:SGD;Acc:S000000746]	biological_process	cytoplasm	carboxy-lyase activity, catalytic activity, lyase activity, magnesium ion binding, molecular_function, thiamine pyrophosphate binding, transferase activity		
YEL020C-B	YEL020C-B	Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028544]					
YEL020W-A	TIM9	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane [Source:SGD;Acc:S000007256]	protein import into mitochondrial inner membrane, protein targeting to mitochondrion, protein transport, transmembrane transport, transport	membrane, mitochondrial inner membrane, mitochondrial inner membrane protein insertion complex, mitochondrial intermembrane space protein transporter complex, mitochondrion	metal ion binding, protein transporter activity, unfolded protein binding		
YEL021W	URA3	Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound [Source:SGD;Acc:S000000747]	'de novo' UMP biosynthetic process, 'de novo' pyrimidine base biosynthetic process, UMP biosynthetic process, metabolic process, pyrimidine nucleotide biosynthetic process	cytosol, soluble fraction	carboxy-lyase activity, catalytic activity, lyase activity, orotidine-5'-phosphate decarboxylase activity		
YEL022W	GEA2	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p [Source:SGD;Acc:S000000748]	ER to Golgi vesicle-mediated transport, actin cytoskeleton organization, intra-Golgi vesicle-mediated transport, macroautophagy, regulation of ARF protein signal transduction, retrograde vesicle-mediated transport, Golgi to ER, secretory granule organization	Golgi cis cisterna, cytoplasm, cytosol, extrinsic to membrane, intracellular, membrane	ARF guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity		
YEL023C	YEL023C	Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene [Source:SGD;Acc:S000000749]	biological_process	cellular_component	molecular_function		
YEL024W	RIP1	Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration [Source:SGD;Acc:S000000750]	aerobic respiration, electron transport chain, mitochondrial electron transport, ubiquinol to cytochrome c, oxidation-reduction process, transport	membrane, mitochondrial respiratory chain complex III, mitochondrion, respiratory chain	2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on diphenols and related substances as donors, ubiquinol-cytochrome-c reductase activity		
YEL025C	YEL025C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000000751]	biological_process	cytoplasm, integral to membrane, membrane, nucleus	molecular_function, protein binding		
YEL026W	SNU13	RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein [Source:SGD;Acc:S000000752]	RNA splicing, mRNA processing, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nuclear mRNA splicing, via spliceosome, rRNA processing, ribosome biogenesis	U4/U6 x U5 tri-snRNP complex, box C/D snoRNP complex, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome, spliceosomal complex	RNA binding		
YEL027W	VMA3	Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis [Source:SGD;Acc:S000000753]	ATP hydrolysis coupled proton transport, ATP synthesis coupled proton transport, cellular copper ion homeostasis, cellular iron ion homeostasis, endocytosis, ion transport, protein targeting to vacuole, proton transport, transport, vacuolar acidification, vacuole organization	integral to membrane, membrane, proton-transporting V-type ATPase, V0 domain, proton-transporting two-sector ATPase complex, proton-transporting domain, vacuolar membrane, vacuolar proton-transporting V-type ATPase, V0 domain, vacuole	hydrogen ion transmembrane transporter activity, hydrolase activity		
YEL028W	YEL028W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000754]					
YEL029C	BUD16	Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) [Source:SGD;Acc:S000000755]	cell cycle, cellular bud site selection, pyridoxal phosphate biosynthetic process, pyridoxine biosynthetic process	cytoplasm, nucleus	ATP binding, kinase activity, metal ion binding, nucleotide binding, pyridoxal kinase activity, transferase activity		
YEL030C-A	YEL030C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028619]					
YEL030W	ECM10	Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations [Source:SGD;Acc:S000000756]	auxin biosynthetic process, protein folding, protein refolding, protein targeting to mitochondrion	mitochondrial nucleoid, mitochondrion	ATP binding, molecular_function, nucleotide binding, unfolded protein binding		
YEL031W	SPF1	P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1 [Source:SGD;Acc:S000000757]	ATP biosynthetic process, auxin biosynthetic process, cation transport, cellular calcium ion homeostasis, metabolic process, transmembrane transport	cis-Golgi network, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, metal ion binding, nucleotide binding		
YEL032C-A	YEL032C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028620]					
YEL032W	MCM3	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex [Source:SGD;Acc:S000000758]	DNA replication, DNA strand elongation involved in DNA replication, DNA-dependent DNA replication initiation, S phase of mitotic cell cycle, auxin biosynthetic process, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, double-strand break repair via break-induced replication, pre-replicative complex assembly	DNA replication preinitiation complex, MCM complex, cytoplasm, nucleus, pre-replicative complex, replication fork protection complex	ATP binding, ATPase activity, DNA binding, DNA replication origin binding, chromatin binding, nucleoside-triphosphatase activity, nucleotide binding		
YEL033W	MTC7	Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant [Source:SGD;Acc:S000000759]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YEL034C-A	YEL034C-A	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A [Source:SGD;Acc:S000028743]					
YEL034W	HYP2	Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Anb1p; structural homolog of bacterial EF-P; undergoes an essential hypusination modification [Source:SGD;Acc:S000000760]	peptidyl-lysine modification to hypusine, positive regulation of translational elongation, positive regulation of translational termination, translation, translational frameshifting	cytoplasm, cytosolic ribosome, mitochondrion	RNA binding, ribosome binding, translation elongation factor activity		
YEL035C	UTR5	Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions [Source:SGD;Acc:S000000761]	biological_process	cellular_component	molecular_function		
YEL036C	ANP1	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol [Source:SGD;Acc:S000000762]	protein N-linked glycosylation	Golgi apparatus, Golgi cis cisterna, Golgi membrane, alpha-1,6-mannosyltransferase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	alpha-1,6-mannosyltransferase activity, mannosyltransferase activity		
YEL037C	RAD23	Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover [Source:SGD;Acc:S000000763]	DNA repair, ER-associated protein catabolic process, nucleotide-excision repair, nucleotide-excision repair, DNA damage recognition, proteasomal ubiquitin-dependent protein catabolic process, protein deglycosylation, response to DNA damage stimulus	cytoplasm, mitochondrion, nucleotide-excision repair factor 2 complex, nucleus, proteasome complex	damaged DNA binding, peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity, protein binding, protein binding, bridging, ubiquitin binding		
YEL038W	UTR4	Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus [Source:SGD;Acc:S000000764]	L-methionine salvage from methylthioadenosine, cellular amino acid biosynthetic process, metabolic process, methionine biosynthetic process	cytoplasm, nucleus	acireductone synthase activity, catalytic activity, hydrolase activity, metal ion binding, phosphoglycolate phosphatase activity		
YEL039C	CYC7	Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration [Source:SGD;Acc:S000000765]	electron transport chain, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial electron transport, ubiquinol to cytochrome c, transport	mitochondrial intermembrane space, mitochondrion, respiratory chain	electron carrier activity, heme binding, iron ion binding, metal ion binding		
YEL040W	UTR2	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck [Source:SGD;Acc:S000000766]	carbohydrate metabolic process, cell wall chitin metabolic process, cellular cell wall organization, fungal-type cell wall organization, metabolic process	anchored to membrane, cell wall, cellular bud neck septin ring, extracellular region, fungal-type cell wall, membrane, membrane fraction	hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, transferase activity, transferring glycosyl groups		
YEL041W	YEF1	ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes [Source:SGD;Acc:S000000767]	NADP biosynthetic process, metabolic process	cellular_component	NAD+ kinase activity, NADH kinase activity, kinase activity, transferase activity		
YEL042W	GDA1	Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate [Source:SGD;Acc:S000000768]	protein glycosylation, protein modification process	Golgi apparatus, Golgi membrane, integral to membrane, membrane	guanosine-diphosphatase activity, hydrolase activity, uridine-diphosphatase activity		
YEL043W	YEL043W	Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold [Source:SGD;Acc:S000000769]	biological_process	endoplasmic reticulum, ribosome	molecular_function, protein binding		
YEL044W	IES6	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes [Source:SGD;Acc:S000000770]	biological_process	nucleus	molecular_function		
YEL045C	YEL045C	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress [Source:SGD;Acc:S000000771]					
YEL046C	GLY1	Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis [Source:SGD;Acc:S000000772]	cellular amino acid metabolic process, glycine biosynthetic process, threonine catabolic process	cytosol	L-allo-threonine aldolase activity, catalytic activity, lyase activity, pyridoxal phosphate binding, threonine aldolase activity		
YEL047C	YEL047C	Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000773]	cellular response to anoxia, oxidation-reduction process	cytoplasm, cytosol, mitochondrion, plasma membrane enriched fraction, ribosome	electron carrier activity, fumarate reductase (NADH) activity, oxidoreductase activity, succinate dehydrogenase activity		
YEL048C	TCA17	Protein that interacts with subunits of the TRAPP complex and may play a role its assembly or stability; mutation is synthetically lethal with gcs1 deletion; Sedlin_N family member; human Sedlin mutations cause the skeletal disorder SEDT [Source:SGD;Acc:S000000774]	ER to Golgi vesicle-mediated transport, biological_process, transport	Golgi apparatus, TRAPP complex, clathrin-coated vesicle, intracellular	molecular_function		
YEL049W	PAU2	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme [Source:SGD;Acc:S000000775]	biological_process, response to stress	cellular_component, integral to membrane, membrane	molecular_function		
YEL050C	RML2	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor [Source:SGD;Acc:S000000776]	fatty acid metabolic process, translation	intracellular, large ribosomal subunit, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome, transferase activity		
YEL050W-A	YEL050W-A	Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028545]					
YEL051W	VMA8	Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis [Source:SGD;Acc:S000000777]	ATP hydrolysis coupled proton transport, ATP synthesis coupled proton transport, ion transport, proton transport, transport, vacuolar acidification	fungal-type vacuole membrane, proton-transporting two-sector ATPase complex, catalytic domain, vacuolar proton-transporting V-type ATPase, V1 domain	ATPase activity, coupled to transmembrane movement of substances, hydrolase activity, proton-transporting ATPase activity, rotational mechanism		
YEL052W	AFG1	Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain [Source:SGD;Acc:S000000778]	cellular response to oxidative stress, misfolded or incompletely synthesized protein catabolic process, protein import into peroxisome matrix	mitochondrial inner membrane, mitochondrion	ATP binding, molecular_function, nucleotide binding		
YEL053C	MAK10	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible [Source:SGD;Acc:S000000779]	N-terminal protein amino acid acetylation	NatC complex, cytoplasm	peptide alpha-N-acetyltransferase activity		
YEL053W-A	YEL053W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C [Source:SGD;Acc:S000028744]					
YEL054C	RPL12A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins [Source:SGD;Acc:S000000780]	ribosomal large subunit assembly, translation	cytoplasm, cytosolic large ribosomal subunit, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YEL055C	POL5	DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA [Source:SGD;Acc:S000000781]	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, rRNA transcription	nucleolus	DNA binding, DNA-directed DNA polymerase activity, binding, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, transferase activity		
YEL056W	HAT2	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing [Source:SGD;Acc:S000000782]	DNA repair, chromatin assembly or disassembly, chromatin modification, chromatin silencing at telomere, histone acetylation, response to DNA damage stimulus	cytoplasm, histone acetyltransferase complex, nucleus	acyltransferase activity, histone acetyltransferase activity, histone binding, protein binding, transferase activity		
YEL057C	YEL057C	Protein of unknown function involved in telomere maintenance; target of UME6 regulation [Source:SGD;Acc:S000000783]	biological_process	cellular_component	molecular_function		
YEL058W	PCM1	Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors [Source:SGD;Acc:S000000784]	carbohydrate metabolic process, fungal-type cell wall chitin biosynthetic process	cytoplasm, nucleus	intramolecular transferase activity, phosphotransferases, isomerase activity, magnesium ion binding, metal ion binding, phosphoacetylglucosamine mutase activity		
YEL059C-A	SOM1	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000002954]	mitochondrial respiratory chain complex assembly, proteolysis	membrane, mitochondrial inner membrane, mitochondrial inner membrane peptidase complex, mitochondrion	endopeptidase activity		
YEL059W	HHY1	Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking [Source:SGD;Acc:S000000785]					
YEL060C	PRB1	Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p [Source:SGD;Acc:S000000786]	cellular response to starvation, negative regulation of catalytic activity, proteolysis, sporulation resulting in formation of a cellular spore, vacuolar protein catabolic process	fungal-type vacuole, fungal-type vacuole lumen, vacuole	hydrolase activity, identical protein binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity		
YEL061C	CIN8	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation [Source:SGD;Acc:S000000787]	auxin biosynthetic process, cell cycle, cell division, microtubule depolymerization, microtubule-based movement, mitosis, mitotic anaphase B, mitotic sister chromatid segregation, mitotic spindle organization in nucleus, spindle pole body separation	astral microtubule, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinesin complex, kinetochore microtubule, microtubule, mitochondrion, spindle, spindle microtubule	ATP binding, microtubule motor activity, motor activity, nucleotide binding		
YEL062W	NPR2	Component of an evolutionarily conserved Npr2/3 complex that mediates downregulation of TORC1 activity in response to amino acid limitation; homolog of human NPRL2; target of Grr1p (E3 ligase); required for growth on urea and proline [Source:SGD;Acc:S000000788]	cellular response to amino acid starvation, cellular response to nitrogen starvation, proline transport, regulation of TOR signaling cascade, response to drug, urea transport	cellular_component	molecular_function		
YEL063C	CAN1	Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance [Source:SGD;Acc:S000000789]	amino acid transport, basic amino acid transport, transmembrane transport, transport	integral to membrane, membrane, membrane raft, mitochondrion, plasma membrane	amino acid transmembrane transporter activity, arginine transmembrane transporter activity, basic amino acid transmembrane transporter activity		
YEL064C	AVT2	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000000790]	amino acid transport, transport	endoplasmic reticulum, integral to membrane, membrane, vacuolar membrane, vacuole	transporter activity		
YEL065W	SIT1	Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000000791]	cellular iron ion homeostasis, ion transport, iron ion transport, siderophore transport, transmembrane transport, transport	cytoplasmic membrane-bounded vesicle, endosome, endosome membrane, integral to membrane, membrane	siderophore uptake transmembrane transporter activity		
YEL066W	HPA3	D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro [Source:SGD;Acc:S000000792]	D-amino acid metabolic process, metabolic process	cytoplasm, nucleus	D-amino-acid N-acetyltransferase activity, N-acetyltransferase activity, acyltransferase activity, transferase activity		
YEL067C	YEL067C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000793]	biological_process	mitochondrion	molecular_function		
YEL068C	YEL068C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000794]					
YEL069C	HXT13	Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose [Source:SGD;Acc:S000000795]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	fructose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YEL070W	DSF1	Deletion suppressor of mpt5 mutation [Source:SGD;Acc:S000000796]	biological_process, metabolic process, oxidation-reduction process	cellular_component	binding, catalytic activity, coenzyme binding, molecular_function, oxidoreductase activity		
YEL071W	DLD3	D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm [Source:SGD;Acc:S000000797]	filamentous growth, lactate metabolic process, oxidation-reduction process	cytoplasm, soluble fraction	D-lactate dehydrogenase (cytochrome) activity, catalytic activity, flavin adenine dinucleotide binding, oxidoreductase activity		
YEL072W	RMD6	Protein required for sporulation [Source:SGD;Acc:S000000798]	biological_process, meiosis, sporulation resulting in formation of a cellular spore	cellular_component	molecular_function		
YEL073C	YEL073C	Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline [Source:SGD;Acc:S000000799]	biological_process	cellular_component	molecular_function		
YEL074W	YEL074W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large scale expression analysis showed an increase in mRNA accumulation in strains mutant for exosome components. [Source:SGD;Acc:S000000800]					
YEL075C	YEL075C	Putative protein of unknown function [Source:SGD;Acc:S000000801]	biological_process	cellular_component	molecular_function		
YEL075W-A	YEL075W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002956]					
YEL076C	YEL076C	Putative protein of unknown function [Source:SGD;Acc:S000000802]	biological_process	cellular_component	molecular_function		
YEL076C-A	YEL076C-A	Putative protein of unknown function [Source:SGD;Acc:S000002955]	biological_process	cellular_component	molecular_function		
YEL077C	YEL077C	Helicase-like protein encoded within the telomeric Y' element [Source:SGD;Acc:S000006409]	biological_process	cellular_component	ATP binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YEL077W-A	YEL077W-A	Dubious open reading frame, unlike to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028621]					
YER001W	MNN1	Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family [Source:SGD;Acc:S000000803]	N-glycan processing, protein O-linked glycosylation	Golgi apparatus, Golgi membrane, integral to membrane, membrane	alpha-1,3-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YER002W	NOP16	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis [Source:SGD;Acc:S000000804]	rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor, ribonucleoprotein complex	molecular_function		
YER003C	PMI40	Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation [Source:SGD;Acc:S000000805]	GDP-mannose biosynthetic process, carbohydrate metabolic process, cell wall mannoprotein biosynthetic process, protein glycosylation	cytoplasm, nucleus	isomerase activity, mannose-6-phosphate isomerase activity, metal ion binding, zinc ion binding		
YER004W	FMP52	Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000000806]	biological_process, metabolic process	endoplasmic reticulum, membrane, mitochondrial outer membrane, mitochondrion	binding, catalytic activity, molecular_function		
YER005W	YND1	Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p [Source:SGD;Acc:S000000807]	lipid metabolic process, protein glycosylation, sphingolipid metabolic process	COPI-coated vesicle, Golgi apparatus, integral to membrane, membrane, microsome	ATP binding, hydrolase activity, nucleoside-diphosphatase activity, nucleoside-triphosphatase activity, nucleotide binding, transferase activity		
YER006C-A	YER006C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PAC2 [Source:SGD;Acc:S000028745]					
YER006W	NUG1	GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus [Source:SGD;Acc:S000000808]	protein transport, rRNA processing, ribosomal large subunit export from nucleus, ribosome biogenesis, transport	intracellular, nucleolus, nucleus, preribosome, large subunit precursor	GTP binding, GTPase activity, RNA binding, nucleotide binding		
YER007C-A	TMA20	Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1 [Source:SGD;Acc:S000002957]	ribosome biogenesis, translation	cytoplasm, ribosome	RNA binding		
YER007W	PAC2	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl [Source:SGD;Acc:S000000809]	protein folding	cellular_component, cytoplasm, cytoskeleton, microtubule	alpha-tubulin binding		
YER008C	SEC3	Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion [Source:SGD;Acc:S000000810]	Golgi to plasma membrane transport, bipolar cellular bud site selection, cytokinesis, exocytosis, protein transport, transport, vesicle docking involved in exocytosis, vesicle fusion	cellular bud neck, cellular bud tip, exocyst, incipient cellular bud site, mating projection tip, site of polarized growth	phosphatidylinositol-4,5-bisphosphate binding		
YER009W	NTF2	Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport [Source:SGD;Acc:S000000811]	nucleocytoplasmic transport, protein import into nucleus, protein transport, transport	cytoplasm, intracellular, nuclear envelope	Ran GTPase binding		
YER010C	YER010C	Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction [Source:SGD;Acc:S000000812]	biological_process	cellular_component	molecular_function		
YER011W	TIR1	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking [Source:SGD;Acc:S000000813]	response to stress	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	structural constituent of cell wall		
YER012W	PRE1	Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle [Source:SGD;Acc:S000000814]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteolysis involved in cellular protein catabolic process	cytoplasm, endoplasmic reticulum membrane, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex, proteasome storage granule	endopeptidase activator activity, endopeptidase activity, hydrolase activity, peptidase activity, threonine-type endopeptidase activity		
YER013W	PRP22	DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes [Source:SGD;Acc:S000000815]	RNA splicing, auxin biosynthetic process, generation of catalytic spliceosome for second transesterification step, mRNA processing, spliceosome disassembly	U2-type catalytic step 2 spliceosome, U2-type post-spliceosomal complex, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, second spliceosomal transesterification activity		
YER014C-A	BUD25	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern [Source:SGD;Acc:S000007590]	cellular bud site selection, response to DNA damage stimulus	cellular_component	molecular_function		
YER014W	HEM14	Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides [Source:SGD;Acc:S000000816]	heme biosynthetic process, oxidation-reduction process, porphyrin biosynthetic process	membrane, mitochondrial inner membrane, mitochondrion	oxidoreductase activity, oxygen-dependent protoporphyrinogen oxidase activity		
YER015W	FAA2	Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome [Source:SGD;Acc:S000000817]	fatty acid metabolic process, lipid metabolic process, long-chain fatty acid metabolic process, metabolic process	cytoplasm, mitochondrion, peroxisome	ATP binding, catalytic activity, ligase activity, long-chain fatty acid-CoA ligase activity, medium-chain fatty acid-CoA ligase activity, nucleotide binding, very long-chain fatty acid-CoA ligase activity		
YER016W	BIM1	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally [Source:SGD;Acc:S000000818]	cell cycle, cell division, microtubule depolymerization, microtubule nucleation, mitosis, mitotic cell cycle spindle assembly checkpoint, mitotic sister chromatid cohesion, negative regulation of microtubule depolymerization, nuclear migration along microtubule, positive regulation of microtubule polymerization	cytoplasm, cytoplasmic microtubule, cytoskeleton, kinetochore, microtubule, microtubule plus end, spindle, spindle midzone, spindle pole, spindle pole body	microtubule binding, microtubule plus-end binding, protein binding, protein homodimerization activity, structural constituent of cytoskeleton		
YER017C	AFG3	Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes [Source:SGD;Acc:S000000819]	auxin biosynthetic process, protein catabolic process, protein complex assembly, protein import into mitochondrial intermembrane space, proteolysis, signal peptide processing	integral to membrane, m-AAA complex, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion	ATP binding, ATPase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, nucleoside-triphosphatase activity, nucleotide binding, peptidase activity, zinc ion binding		
YER018C	SPC25	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering [Source:SGD;Acc:S000000820]	cell cycle, cell division, chromosome segregation, microtubule nucleation, mitosis	Ndc80 complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, condensed nuclear chromosome, centromeric region, kinetochore, nucleus	structural constituent of cytoskeleton		
YER019C-A	SBH2	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p [Source:SGD;Acc:S000002127]	SRP-dependent cotranslational protein targeting to membrane, protein transport, transmembrane transport, transport	Ssh1 translocon complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	ARF guanyl-nucleotide exchange factor activity		
YER019W	ISC1	Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance [Source:SGD;Acc:S000000821]	ceramide biosynthetic process, response to salt stress, sphingolipid catabolic process	endoplasmic reticulum, integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrion	hydrolase activity, metal ion binding, phospholipase C activity		
YER020W	GPA2	Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000000822]	G-protein coupled receptor protein signaling pathway, activation of adenylate cyclase activity by G-protein signaling pathway, ascospore formation, glucose mediated signaling pathway, hexose mediated signaling, pseudohyphal growth, regulation of cell size, replicative cell aging, signal transduction	cell cortex, cytoplasm, mitochondrion, plasma membrane, plasma membrane enriched fraction	GTP binding, GTPase activity, guanyl nucleotide binding, nucleotide binding, signal transducer activity		
YER021W	RPN3	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control [Source:SGD;Acc:S000000823]	regulation of protein catabolic process, ubiquitin-dependent protein catabolic process	proteasome complex, proteasome regulatory particle, lid subcomplex	enzyme regulator activity, molecular_function, protein binding		
YER022W	SRB4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; similar to the human MED17 gene [Source:SGD;Acc:S000000824]	transcription from RNA polymerase II promoter	mediator complex, nucleus			
YER023C-A	YER023C-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028622]					
YER023W	PRO3	Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis [Source:SGD;Acc:S000000825]	cellular amino acid biosynthetic process, metabolic process, oxidation-reduction process, proline biosynthetic process	cytoplasm	binding, catalytic activity, oxidoreductase activity, pyrroline-5-carboxylate reductase activity		
YER024W	YAT2	Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane [Source:SGD;Acc:S000000826]	alcohol metabolic process, carnitine metabolic process, fatty acid metabolic process, lipid metabolic process, transport	cytoplasm, cytosol	acyltransferase activity, carnitine O-acetyltransferase activity, transferase activity		
YER025W	GCD11	Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met [Source:SGD;Acc:S000000827]	positive regulation of translational fidelity, translation	eukaryotic translation initiation factor 2 complex, multi-eIF complex, ribosome	GTP binding, GTPase activity, nucleotide binding, tRNA binding, translation initiation factor activity		
YER026C	CHO1	Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline [Source:SGD;Acc:S000000828]	CDP-diacylglycerol metabolic process, phosphatidylserine biosynthetic process, phospholipid biosynthetic process	endoplasmic reticulum, integral to membrane, membrane, microsome, mitochondrial outer membrane, mitochondrion	CDP-diacylglycerol-serine O-phosphatidyltransferase activity, phosphotransferase activity, for other substituted phosphate groups, transferase activity		
YER027C	GAL83	One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain [Source:SGD;Acc:S000000829]	cell adhesion, invasive growth in response to glucose limitation, protein phosphorylation, regulation of protein complex assembly, signal transduction	AMP-activated protein kinase complex, cytoplasm, nuclear envelope lumen, nucleus	AMP-activated protein kinase activity		
YER028C	MIG3	Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes [Source:SGD;Acc:S000000830]	negative regulation of transcription from RNA polymerase II promoter, response to DNA damage stimulus, transcription initiation, DNA-dependent	cytoplasm, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YER029C	SMB1	Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B' [Source:SGD;Acc:S000000831]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, nucleus, ribonucleoprotein complex	RNA binding, molecular_function		
YER030W	CHZ1	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif [Source:SGD;Acc:S000000832]	chromatin remodeling	chromatin assembly complex, nucleus	histone binding		
YER031C	YPT31	Rab family GTPase, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi [Source:SGD;Acc:S000000833]	early endosome to Golgi transport, exocytosis, protein transport, small GTPase mediated signal transduction, transport, vesicle-mediated transport	Golgi apparatus, Golgi membrane, endosome, membrane, mitochondrial outer membrane	GTP binding, GTPase activity, nucleotide binding		
YER032W	FIR1	Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate [Source:SGD;Acc:S000000834]	RNA polyadenylation, mRNA polyadenylation, mRNA processing	cellular bud neck	molecular_function		
YER033C	ZRG8	Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency [Source:SGD;Acc:S000000835]	fungal-type cell wall organization	cellular bud, cellular bud neck, cellular bud tip, cytoplasm, mating projection tip, mitochondrion	molecular_function		
YER034W	YER034W	Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage [Source:SGD;Acc:S000000836]	biological_process	cytoplasm, nucleus	molecular_function		
YER035W	EDC2	RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress [Source:SGD;Acc:S000000837]	deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA processing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of translation in response to stress	cytoplasm, nucleolus, nucleus	RNA binding, mRNA binding		
YER036C	ARB1	ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p [Source:SGD;Acc:S000000838]	auxin biosynthetic process, ribosomal small subunit export from nucleus, ribosome biogenesis, transport	cytoplasm, nucleus, ribosome	ATP binding, ATPase activity, ATPase activity, uncoupled, nucleoside-triphosphatase activity, nucleotide binding		
YER037W	PHM8	Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p [Source:SGD;Acc:S000000839]	cellular response to phosphate starvation, metabolic process	cytoplasm, nucleus	catalytic activity, hydrolase activity, lysophosphatidic acid phosphatase activity		
YER038C	KRE29	Essential subunit of the Mms21-Smc5-Smc6 complex, required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance [Source:SGD;Acc:S000000840]	DNA recombination, DNA repair, response to DNA damage stimulus	Smc5-Smc6 complex, cytoplasm, nucleus	molecular_function		
YER038W-A	YER038W-A	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria [Source:SGD;Acc:S000028746]					
YER039C	HVG1	Protein of unknown function, has homology to Vrg4p [Source:SGD;Acc:S000000841]	biological_process, carbohydrate transport, nucleotide-sugar transport, transmembrane transport, transport	Golgi apparatus, Golgi membrane, cellular_component, cytoplasmic vesicle, cytoplasmic vesicle membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function, nucleotide-sugar transmembrane transporter activity		
YER039C-A	YER039C-A	Putative protein of unknown function; YER039C-A is not an essential gene [Source:SGD;Acc:S000007226]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YER040W	GLN3	Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source [Source:SGD;Acc:S000000842]	nitrate assimilation, nitrogen catabolite activation of transcription, regulation of transcription, DNA-dependent	cytosol, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YER041W	YEN1	Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p [Source:SGD;Acc:S000000843]	DNA repair, response to DNA damage stimulus	cytoplasm, nucleus	DNA binding, catalytic activity, crossover junction endodeoxyribonuclease activity, endonuclease activity, nuclease activity, single-stranded DNA specific endodeoxyribonuclease activity		
YER042W	MXR1	Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan [Source:SGD;Acc:S000000844]	cellular response to oxidative stress, oxidation-reduction process, protein metabolic process	cytoplasm, nucleus	oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor, peptide-methionine-(S)-S-oxide reductase activity		
YER043C	SAH1	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor [Source:SGD;Acc:S000000845]	metabolic process, methionine metabolic process, one-carbon metabolic process, selenocysteine metabolic process	cytoplasm	adenosylhomocysteinase activity, binding, catalytic activity, hydrolase activity		
YER044C	ERG28	Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p [Source:SGD;Acc:S000000846]	ergosterol biosynthetic process, lipid biosynthetic process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	protein binding, bridging		
YER044C-A	MEI4	Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores [Source:SGD;Acc:S000001954]	DNA recombination, meiosis, meiotic DNA double-strand break formation, sporulation resulting in formation of a cellular spore	chromosome, condensed nuclear chromosome, nucleus	molecular_function		
YER045C	ACA1	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources [Source:SGD;Acc:S000000847]	regulation of transcription, DNA-dependent, transcription initiation from RNA polymerase II promoter	nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YER046W	SPO73	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis [Source:SGD;Acc:S000000848]	ascospore formation, ascospore wall assembly, sporulation resulting in formation of a cellular spore	cytoplasm, cytosol, integral to membrane	molecular_function		
YER046W-A	YER046W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028747]					
YER047C	SAP1	Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system [Source:SGD;Acc:S000000849]	auxin biosynthetic process, biological_process	cytoplasm	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding		
YER048C	CAJ1	Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly [Source:SGD;Acc:S000000850]	protein folding	nucleus	chaperone binding, heat shock protein binding, unfolded protein binding		
YER048W-A	ISD11	Protein required for mitochondrial iron-sulfur cluster biosynthesis [Source:SGD;Acc:S000007237]	iron-sulfur cluster assembly	extrinsic to mitochondrial inner membrane, mitochondrial matrix, mitochondrion	molecular_function		
YER049W	TPA1	Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate [Source:SGD;Acc:S000000851]	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, oxidation-reduction process, translational termination	nucleus	L-ascorbic acid binding, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, poly(A) RNA binding		
YER050C	RSM18	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein [Source:SGD;Acc:S000000852]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YER051W	JHD1	JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe [Source:SGD;Acc:S000000853]	chromatin modification, histone demethylation, oxidation-reduction process	cellular_component, nucleus	histone demethylase activity (H3-K36 specific), metal ion binding, methylated histone residue binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, protein binding, zinc ion binding		
YER052C	HOM3	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis [Source:SGD;Acc:S000000854]	cellular amino acid biosynthetic process, homoserine biosynthetic process, metabolic process, methionine metabolic process, threonine biosynthetic process	cytoplasm	ATP binding, amino acid binding, aspartate kinase activity, kinase activity, nucleotide binding, transferase activity		
YER053C	PIC2	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature [Source:SGD;Acc:S000000855]	phosphate transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, inorganic phosphate transmembrane transporter activity		
YER053C-A	YER053C-A	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum [Source:SGD;Acc:S000007523]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YER054C	GIP2	Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p [Source:SGD;Acc:S000000856]	glycogen metabolic process, protein dephosphorylation	protein phosphatase type 1 complex	protein binding, protein phosphatase regulator activity		
YER055C	HIS1	ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control [Source:SGD;Acc:S000000857]	cellular amino acid biosynthetic process, histidine biosynthetic process	cytoplasm, intracellular	ATP binding, ATP phosphoribosyltransferase activity, magnesium ion binding, nucleotide binding, transferase activity, transferase activity, transferring glycosyl groups		
YER056C	FCY2	Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation [Source:SGD;Acc:S000000858]	cytidine transport, cytosine transport, nucleobase, nucleoside, nucleotide and nucleic acid transport, purine base transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	cytidine transmembrane transporter activity, nucleobase transmembrane transporter activity		
YER056C-A	RPL34A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein [Source:SGD;Acc:S000002135]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YER057C	HMF1	Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro [Source:SGD;Acc:S000000859]	biological_process	cytoplasm, cytosol, nucleus	molecular_function		
YER058W	PET117	Protein required for assembly of cytochrome c oxidase [Source:SGD;Acc:S000000860]	mitochondrial respiratory chain complex IV assembly	mitochondrial inner membrane, mitochondrion	molecular_function		
YER059W	PCL6	Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding [Source:SGD;Acc:S000000861]	carbohydrate metabolic process, glycogen metabolic process, regulation of glycogen biosynthetic process, regulation of glycogen catabolic process	cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus	cyclin-dependent protein kinase regulator activity		
YER060W	FCY21	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function [Source:SGD;Acc:S000000862]	nucleobase, nucleoside, nucleotide and nucleic acid transport, transmembrane transport, transport	integral to membrane, membrane	nucleobase transmembrane transporter activity		
YER060W-A	FCY22	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function [Source:SGD;Acc:S000002958]	nucleobase, nucleoside, nucleotide and nucleic acid transport, transmembrane transport, transport	integral to membrane, membrane	nucleobase transmembrane transporter activity		
YER061C	CEM1	Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration [Source:SGD;Acc:S000000863]	biosynthetic process, fatty acid biosynthetic process, lipid biosynthetic process, metabolic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity, acyltransferase activity, catalytic activity, fatty acid synthase activity, transferase activity, transferase activity, transferring acyl groups other than amino-acyl groups		
YER062C	HOR2	One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition [Source:SGD;Acc:S000000864]	cellular carbohydrate metabolic process, glycerol biosynthetic process, metabolic process, response to osmotic stress, response to stress	cytoplasm, nucleus	catalytic activity, glycerol-1-phosphatase activity, hydrolase activity		
YER063W	THO1	Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation [Source:SGD;Acc:S000000865]	poly(A)+ mRNA export from nucleus, ribonucleoprotein complex assembly, transcription, DNA-dependent	nucleus	RNA binding, chromatin binding, double-stranded DNA binding, nucleic acid binding		
YER064C	YER064C	Non-essential nuclear protein; null mutation has global effects on transcription [Source:SGD;Acc:S000000866]		nucleus	DNA binding, molecular_function		
YER065C	ICL1	Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose [Source:SGD;Acc:S000000867]	carboxylic acid metabolic process, glyoxylate cycle, metabolic process, tricarboxylic acid cycle	cellular_component, cytoplasm	catalytic activity, isocitrate lyase activity, lyase activity		
YER066C-A	YER066C-A	Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W [Source:SGD;Acc:S000002959]					
YER066W	RRT13	Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription [Source:SGD;Acc:S000000868]	biological_process	cellular_component	molecular_function, protein binding		
YER067C-A	YER067C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W [Source:SGD;Acc:S000028748]					
YER067W	RGI1	Protein of unknown function involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion [Source:SGD;Acc:S000000869]	energy reserve metabolic process	cell periphery, cytoplasm, membrane, membrane fraction, nucleus, plasma membrane	molecular_function		
YER068C-A	YER068C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028749]					
YER068W	MOT2	Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p [Source:SGD;Acc:S000000870]	conjugation with cellular fusion, nuclear-transcribed mRNA poly(A) tail shortening, protein polyubiquitination, protein ubiquitination, regulation of transcription from RNA polymerase II promoter, transcription elongation from RNA polymerase II promoter	CCR4-NOT core complex, cytoplasm, nucleus	RNA binding, metal ion binding, nucleic acid binding, nucleotide binding, protein binding, sequence-specific DNA binding, ubiquitin-protein ligase activity, zinc ion binding		
YER069W	ARG5,6	Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p [Source:SGD;Acc:S000000871]	arginine biosynthetic process, cellular amino acid biosynthetic process, cellular amino acid metabolic process, metabolic process, ornithine biosynthetic process, oxidation-reduction process	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, N-acetyl-gamma-glutamyl-phosphate reductase activity, NAD binding, acetylglutamate kinase activity, binding, catalytic activity, kinase activity, nucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, protein dimerization activity, transferase activity		
YER070W	RNR1	Major isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits [Source:SGD;Acc:S000000872]	DNA replication, deoxyribonucleotide biosynthetic process, oxidation-reduction process	cytoplasm, ribonucleoside-diphosphate reductase complex	ATP binding, catalytic activity, nucleotide binding, oxidoreductase activity, ribonucleoside-diphosphate reductase activity		
YER071C	YER071C	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000000873]	biological_process	cytoplasm, mating projection tip	molecular_function		
YER072W	VTC1	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity [Source:SGD;Acc:S000000874]	microautophagy, polyphosphate metabolic process, vacuolar transport, vacuole fusion, non-autophagic	endoplasmic reticulum, integral to membrane, intrinsic to vacuolar membrane, membrane, vacuolar membrane, vacuolar transporter chaperone complex, vacuole	mRNA binding		
YER073W	ALD5	Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed [Source:SGD;Acc:S000000875]	acetate biosynthetic process, metabolic process, oxidation-reduction process	mitochondrial matrix, mitochondrion	aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase (NADP+) activity, aldehyde dehydrogenase [NAD(P)+] activity, oxidoreductase activity		
YER074W	RPS24A	Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein [Source:SGD;Acc:S000000876]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, mitochondrion, ribonucleoprotein complex, ribosome	nucleotide binding, structural constituent of ribosome		
YER074W-A	YOS1	Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p [Source:SGD;Acc:S000007651]	ER to Golgi vesicle-mediated transport, protein transport, transport, vesicle-mediated transport	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to Golgi membrane, integral to membrane, membrane	molecular_function		
YER075C	PTP3	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm [Source:SGD;Acc:S000000877]	dephosphorylation, inactivation of MAPK activity involved in osmosensory signaling pathway, pheromone-dependent signal transduction involved in conjugation with cellular fusion, protein dephosphorylation	cytoplasm, nucleus	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity		
YER076C	YER076C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization [Source:SGD;Acc:S000000878]	biological_process	membrane fraction, mitochondrion	molecular_function		
YER076W-A	YER076W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C [Source:SGD;Acc:S000028750]					
YER077C	YER077C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport [Source:SGD;Acc:S000000879]	biological_process	mitochondrion	molecular_function		
YER078C	ICP55	Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family [Source:SGD;Acc:S000000880]	cellular process, protein maturation by peptide bond cleavage, protein stabilization, proteolysis	extrinsic to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion, nucleus	aminopeptidase activity, hydrolase activity, manganese ion binding, metal ion binding, metalloexopeptidase activity, metallopeptidase activity, peptidase activity		
YER078W-A	YER078W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028546]	biological_process	cellular_component	molecular_function		
YER079C-A	YER079C-A	Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER080W [Source:SGD;Acc:S000028751]					
YER079W	YER079W	Putative protein of unknown function [Source:SGD;Acc:S000000881]	biological_process	cytoplasm, nucleus	molecular_function		
YER080W	AIM9	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000000882]	biological_process	mitochondrion	molecular_function		
YER081W	SER3	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p [Source:SGD;Acc:S000000883]	L-serine biosynthetic process, cellular amino acid biosynthetic process, metabolic process, oxidation-reduction process, serine family amino acid biosynthetic process	cytoplasm	NAD binding, binding, catalytic activity, cofactor binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, phosphoglycerate dehydrogenase activity		
YER082C	UTP7	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000000884]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	molecular_function, protein binding		
YER083C	GET2	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division [Source:SGD;Acc:S000000885]	cellular protein localization, protein insertion into ER membrane, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	GET complex, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	protein anchor		
YER084W	YER084W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000886]					
YER084W-A	YER084W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028752]					
YER085C	YER085C	Putative protein of unknown function [Source:SGD;Acc:S000000887]	biological_process	cellular_component	molecular_function		
YER086W	ILV1	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation [Source:SGD;Acc:S000000888]	branched chain family amino acid biosynthetic process, cellular amino acid biosynthetic process, cellular amino acid metabolic process, isoleucine biosynthetic process, metabolic process, threonine catabolic process	mitochondrion	L-threonine ammonia-lyase activity, catalytic activity, lyase activity, pyridoxal phosphate binding		
YER087C-A	YER087C-A	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase [Source:SGD;Acc:S000028753]					
YER087C-B	SBH1	Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p [Source:SGD;Acc:S000002128]	SRP-dependent cotranslational protein targeting to membrane, translocation, posttranslational protein targeting to membrane, translocation, protein transport, transmembrane transport, transport	Sec61 translocon complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	ARF guanyl-nucleotide exchange factor activity, P-P-bond-hydrolysis-driven protein transmembrane transporter activity		
YER087W	AIM10	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000000889]	biological_process, prolyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, proline-tRNA ligase activity		
YER088C	DOT6	Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation [Source:SGD;Acc:S000000890]	chromatin silencing at rDNA, chromatin silencing at telomere, filamentous growth, regulation of transcription from RNA polymerase II promoter, unidimensional cell growth	Rpd3L complex, Rpd3L-Expanded complex, cytoplasm, nucleus	DNA binding, protein binding, sequence-specific DNA binding		
YER088C-A	YER088C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028754]					
YER088W-B	YER088W-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the ORF PTC2/YER089C; identified by gene-trapping, expression analysis, and homology searching [Source:SGD;Acc:S000028623]					
YER089C	PTC2	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA checkpoint [Source:SGD;Acc:S000000891]	DNA damage checkpoint, endoplasmic reticulum unfolded protein response, inactivation of MAPK activity involved in osmosensory signaling pathway, protein dephosphorylation, regulation of cyclin-dependent protein kinase activity	cytoplasm, nucleus, protein serine/threonine phosphatase complex	catalytic activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YER090C-A	YER090C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000029725]					
YER090W	TRP2	Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p [Source:SGD;Acc:S000000892]	aromatic amino acid family biosynthetic process, biosynthetic process, cellular amino acid biosynthetic process, tryptophan biosynthetic process	anthranilate synthase complex, cytoplasm	anthranilate synthase activity, lyase activity, oxo-acid-lyase activity		
YER091C	MET6	Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs [Source:SGD;Acc:S000000893]	cellular amino acid biosynthetic process, methionine biosynthetic process	cytoplasm, plasma membrane enriched fraction	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, metal ion binding, methyltransferase activity, transferase activity, zinc ion binding		
YER091C-A	YER091C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007238]					
YER092W	IES5	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions [Source:SGD;Acc:S000000894]	biological_process	nucleus	molecular_function		
YER093C	TSC11	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain [Source:SGD;Acc:S000000895]	TOR signaling cascade, establishment or maintenance of actin cytoskeleton polarity, fungal-type cell wall organization, regulation of cell growth, sphingolipid biosynthetic process	TORC2 complex, membrane, membrane fraction, plasma membrane, vacuolar membrane, vacuole	binding, guanyl-nucleotide exchange factor activity, protein binding		
YER093C-A	AIM11	Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron [Source:SGD;Acc:S000002960]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YER094C	PUP3	Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 [Source:SGD;Acc:S000000896]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteolysis involved in cellular protein catabolic process	cytoplasm, endoplasmic reticulum membrane, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex, proteasome storage granule	endopeptidase activator activity, endopeptidase activity, hydrolase activity, peptidase activity, threonine-type endopeptidase activity		
YER095W	RAD51	Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein [Source:SGD;Acc:S000000897]	DNA metabolic process, DNA recombination, DNA repair, auxin biosynthetic process, heteroduplex formation, meiotic joint molecule formation, reciprocal meiotic recombination, response to DNA damage stimulus, strand invasion, telomere maintenance via recombination	chromosome, condensed nuclear chromosome, nuclear chromosome, nucleus	ATP binding, DNA binding, DNA-dependent ATPase activity, damaged DNA binding, nucleoside-triphosphatase activity, nucleotide binding, recombinase activity, single-stranded DNA binding		
YER096W	SHC1	Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH [Source:SGD;Acc:S000000898]	ascospore formation, cellular cell wall organization, chitin biosynthetic process, sporulation resulting in formation of a cellular spore	cytoplasm, membrane, prospore membrane	binding, enzyme activator activity		
YER097W	YER097W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000899]					
YER098W	UBP9	Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions [Source:SGD;Acc:S000000900]	protein deubiquitination, ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YER099C	PRS2	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [Source:SGD;Acc:S000000901]	5-phosphoribose 1-diphosphate biosynthetic process, cellular biosynthetic process, fungal-type cell wall organization, nucleoside metabolic process, nucleotide biosynthetic process, ribonucleoside monophosphate biosynthetic process	cytoplasm	ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, ribose phosphate diphosphokinase activity, transferase activity		
YER100W	UBC6	Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway [Source:SGD;Acc:S000000902]	ER-associated protein catabolic process, post-translational protein modification, protein monoubiquitination, protein polyubiquitination, regulation of protein metabolic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	ATP binding, acid-amino acid ligase activity, ligase activity, nucleotide binding, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YER101C	AST2	Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions [Source:SGD;Acc:S000000903]	biological_process, metabolic process, oxidation-reduction process	cytoplasm	binding, catalytic activity, molecular_function, oxidoreductase activity, zinc ion binding		
YER102W	RPS8B	Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein [Source:SGD;Acc:S000000904]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YER103W	SSA4	Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation [Source:SGD;Acc:S000000905]	SRP-dependent cotranslational protein targeting to membrane, translocation, auxin biosynthetic process, protein folding, response to stress	cytoplasm, nucleus	ATP binding, ATPase activity, nucleotide binding, unfolded protein binding		
YER104W	RTT105	Protein with a role in regulation of Ty1 transposition [Source:SGD;Acc:S000000906]	negative regulation of transposition, RNA-mediated, transposition	cytoplasm, nucleus	molecular_function		
YER105C	NUP157	Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly [Source:SGD;Acc:S000000907]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport, protein export from nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	membrane, nuclear membrane, nuclear pore, nucleus	structural constituent of nuclear pore, structural molecule activity		
YER106W	MAM1	Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle [Source:SGD;Acc:S000000908]	meiosis, meiotic chromosome segregation, meiotic sister chromatid cohesion involved in meiosis I	condensed nuclear chromosome kinetochore, monopolin complex, nucleus	molecular_function		
YER107C	GLE2	Component of the Nup82 subcomplex of the nuclear pore complex; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p [Source:SGD;Acc:S000000909]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear envelope organization, nuclear pore organization, protein export from nucleus, protein import into nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	Nup82 complex, membrane, nuclear membrane, nuclear pore, nucleus	protein binding, structural molecule activity		
YER107W-A	YER107W-A	Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C [Source:SGD;Acc:S000028755]					
YER109C	FLO8	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene [Source:SGD;Acc:S000000911]	biofilm formation, flocculation via cell wall protein-carbohydrate interaction, invasive growth in response to glucose limitation, pseudohyphal growth	cytoplasm, nucleus	protein binding		
YER110C	KAP123	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 [Source:SGD;Acc:S000000912]	intracellular protein transport, mRNA transport, protein import into nucleus, protein transport, transmembrane transport, transport	cytoplasm, nuclear pore, nucleus	binding, protein transporter activity		
YER111C	SWI4	DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair [Source:SGD;Acc:S000000913]	regulation of transcription, DNA-dependent	SBF transcription complex, nuclear chromatin, nucleus	DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YER112W	LSM4	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000000914]	RNA splicing, cytoplasmic mRNA processing body assembly, mRNA processing, nuclear mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, rRNA processing, tRNA processing	U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, cytoplasmic mRNA processing body, nucleolus, nucleus, ribonucleoprotein complex, small nucleolar ribonucleoprotein complex	RNA binding, U6 snRNA binding		
YER113C	TMN3	Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation [Source:SGD;Acc:S000000915]	cellular copper ion homeostasis, invasive growth in response to glucose limitation, pseudohyphal growth, vacuolar transport	COPI-coated vesicle, Golgi apparatus, Golgi membrane, integral to membrane, membrane	molecular_function		
YER114C	BOI2	Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain [Source:SGD;Acc:S000000916]	Rho protein signal transduction, budding cell apical bud growth, cytokinesis, completion of separation, establishment of cell polarity	cellular bud, cellular bud neck, cytoplasm, cytoskeleton, site of polarized growth	phospholipid binding, protein binding		
YER115C	SPR6	Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation [Source:SGD;Acc:S000000917]	ascospore formation, meiosis, sporulation resulting in formation of a cellular spore	cellular_component	molecular_function		
YER116C	SLX8	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain [Source:SGD;Acc:S000000918]	DNA repair, protein sumoylation, protein ubiquitination, response to DNA damage stimulus, telomere maintenance	nucleolus, nucleus, ubiquitin ligase complex	ligase activity, metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YER117W	RPL23B	Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins [Source:SGD;Acc:S000000919]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YER118C	SHO1	Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway [Source:SGD;Acc:S000000920]	osmosensory signaling pathway, pseudohyphal growth	integral to membrane, mating projection tip, membrane, plasma membrane	osmosensor activity, protein binding		
YER119C	AVT6	Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation [Source:SGD;Acc:S000000921]	amino acid export from vacuole, amino acid transport, transmembrane transport, transport	fungal-type vacuole, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	L-aspartate transmembrane transporter activity, L-glutamate transmembrane transporter activity, transporter activity		
YER119C-A	YER119C-A	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2 [Source:SGD;Acc:S000002961]					
YER120W	SCS2	Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog [Source:SGD;Acc:S000000922]	chromatin silencing at telomere, endoplasmic reticulum inheritance, negative regulation of transcription factor import into nucleus, phospholipid biosynthetic process, regulation of intracellular lipid transport	cellular bud tip, endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, nuclear envelope, nuclear membrane, nucleus	FFAT motif binding, phosphatidylinositol binding, structural molecule activity		
YER121W	YER121W	Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy [Source:SGD;Acc:S000000923]	biological_process	cellular_component	molecular_function		
YER122C	GLO3	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p [Source:SGD;Acc:S000000924]	COPI coating of Golgi vesicle, ER to Golgi vesicle-mediated transport, protein transport, regulation of ARF GTPase activity, retrograde vesicle-mediated transport, Golgi to ER, transport	COPI vesicle coat, COPI-coated vesicle, ER-Golgi intermediate compartment, Golgi apparatus	ARF GTPase activator activity, GTPase activator activity, metal ion binding, zinc ion binding		
YER123W	YCK3	Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway [Source:SGD;Acc:S000000925]	protein phosphorylation, vesicle-mediated transport	fungal-type vacuole, fungal-type vacuole membrane, membrane, nuclear membrane, nucleus, plasma membrane, vacuolar membrane, vacuole	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YER124C	DSE1	Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall [Source:SGD;Acc:S000000926]	cell cycle, cell division, cellular cell wall organization, cytokinesis, completion of separation, invasive growth in response to glucose limitation, regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion	cellular bud neck	molecular_function, protein binding		
YER125W	RSP5	E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes, including MVB sorting, heat shock response, transcription, and endocytosis; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy [Source:SGD;Acc:S000000927]	cellular response to UV, chromatin assembly or disassembly, late endosome to vacuole transport via multivesicular body sorting pathway, mitochondrion organization, positive regulation of endocytosis, positive regulation of fatty acid biosynthetic process, positive regulation of receptor-mediated endocytosis, proteasomal ubiquitin-dependent protein catabolic process, protein modification process, protein monoubiquitination, protein polyubiquitination, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, regulation of actin cytoskeleton organization, regulation of dolichol biosynthetic process, regulation of ergosterol biosynthetic process, regulation of mRNA export from nucleus, regulation of multivesicular body size, regulation of nitrogen utilization, regulation of phosphate metabolic process, regulation of protein localization, regulation of rRNA processing, regulation of ribosomal large subunit export from nucleus, regulation of tRNA export from nucleus, regulation of tRNA processing, regulation of ubiquinone biosynthetic process, response to drug, ribophagy, ubiquitin-dependent endocytosis, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	Golgi apparatus, cellular bud tip, cytoplasm, endosome membrane, extrinsic to internal side of plasma membrane, intracellular, mitochondrion, nucleus, plasma membrane enriched fraction, ubiquitin ligase complex	acid-amino acid ligase activity, ligase activity, phosphatidylinositol binding, protein binding, ubiquitin binding, ubiquitin-protein ligase activity		
YER126C	NSA2	Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA [Source:SGD;Acc:S000000928]	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor	molecular_function		
YER127W	LCP5	Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus [Source:SGD;Acc:S000000929]	rRNA modification, rRNA processing, ribosome biogenesis	nucleolus, nucleus, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, small nucleolar ribonucleoprotein complex	RNA binding		
YER128W	YER128W	Putative protein of unknown function [Source:SGD;Acc:S000000930]	biological_process	cellular_component	molecular_function		
YER129W	SAK1	Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome [Source:SGD;Acc:S000000931]	DNA-dependent DNA replication, auxin biosynthetic process, glucose metabolic process, protein phosphorylation	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YER130C	YER130C	Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; the C. Albicans homolog (MNL1) plays a role in adaptation to stress [Source:SGD;Acc:S000000932]	biological_process	cellular_component, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YER131W	RPS26B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein [Source:SGD;Acc:S000000933]	rRNA export from nucleus, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YER132C	PMD1	Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions [Source:SGD;Acc:S000000934]	meiosis, sporulation resulting in formation of a cellular spore	cytoplasm	molecular_function		
YER133W	GLC7	Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits [Source:SGD;Acc:S000000935]	DNA damage checkpoint, DNA replication checkpoint, ascospore formation, carbohydrate metabolic process, cell budding, cell cycle, cell division, cellular ion homeostasis, chromosome segregation, glycogen metabolic process, histone dephosphorylation, mRNA processing, meiosis, mitosis, mitotic cell cycle spindle assembly checkpoint, protein dephosphorylation, protein localization to kinetochore, rRNA processing, regulation of carbohydrate metabolic process, regulation of cell cycle, regulation of cell shape during vegetative growth phase, replication fork processing, response to heat, termination of RNA polymerase II transcription, exosome-dependent, termination of RNA polymerase II transcription, poly(A)-coupled	cellular bud neck, condensed nuclear chromosome kinetochore, cytoplasm, mRNA cleavage and polyadenylation specificity factor complex, mating projection base, nucleolus, nucleus, protein phosphatase type 1 complex, spindle pole body	hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YER133W-A	YER133W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C. [Source:SGD;Acc:S000028756]					
YER134C	YER134C	Putative protein of unknown function; non-essential gene [Source:SGD;Acc:S000000936]	biological_process	cytoplasm, nucleus	hydrolase activity, metal ion binding, molecular_function, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity		
YER135C	YER135C	Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene [Source:SGD;Acc:S000000937]					
YER136W	GDI1	GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins [Source:SGD;Acc:S000000938]	protein transport, regulation of GTPase activity, transport, vesicle-mediated transport	cytoplasm, membrane fraction, soluble fraction	GTPase activator activity, Rab GDP-dissociation inhibitor activity		
YER137C	YER137C	Putative protein of unknown function [Source:SGD;Acc:S000000939]	biological_process	cellular_component	molecular_function, nucleic acid binding, zinc ion binding		
YER137C-A	YER137C-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007402]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YER137W-A	YER137W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028757]					
YER138C	YER138C	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000000940]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YER138W-A	YER138W-A	Putative protein of unknown function [Source:SGD;Acc:S000007239]	biological_process	cellular_component	molecular_function		
YER139C	RTR1	CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm [Source:SGD;Acc:S000000941]	dephosphorylation of RNA polymerase II C-terminal domain, transcription from RNA polymerase II promoter	cytoplasm, nucleus	CTD phosphatase activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity		
YER140W	YER140W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; genetic interactions suggest a role in folding of ER membrane proteins [Source:SGD;Acc:S000000942]	protein folding in endoplasmic reticulum	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YER141W	COX15	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase [Source:SGD;Acc:S000000943]	heme a biosynthetic process, protein complex assembly	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor		
YER142C	MAG1	3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired [Source:SGD;Acc:S000000944]	DNA dealkylation involved in DNA repair, DNA repair, base-excision repair, base-excision repair, AP site formation, metabolic process, response to DNA damage stimulus	nucleus	DNA binding, alkylbase DNA N-glycosylase activity, catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds		
YER143W	DDI1	DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control [Source:SGD;Acc:S000000945]	protein transport, proteolysis, transport, ubiquitin-dependent protein catabolic process, vesicle-mediated transport	cytoplasm, membrane, plasma membrane	SNARE binding, aspartic-type endopeptidase activity, protein binding, ubiquitin binding		
YER144C	UBP5	Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck [Source:SGD;Acc:S000000946]	protein deubiquitination, ubiquitin-dependent protein catabolic process	cellular bud neck, incipient cellular bud site	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YER145C	FTR1	High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron [Source:SGD;Acc:S000000947]	high-affinity iron ion transport, ion transport, iron assimilation by reduction and transport, iron ion transport, transmembrane transport, transport	high affinity iron permease complex, integral to membrane, membrane, plasma membrane	iron ion transmembrane transporter activity		
YER145C-A	YER145C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF LSM5/YER146W [Source:SGD;Acc:S000028758]					
YER146W	LSM5	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000000948]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, rRNA processing, tRNA processing	U4/U6 x U5 tri-snRNP complex, U6 snRNP, nucleolus, nucleus, ribonucleoprotein complex, small nucleolar ribonucleoprotein complex	RNA binding		
YER147C	SCC4	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX [Source:SGD;Acc:S000000949]	cell cycle, cell division, chromosome segregation, double-strand break repair, establishment of protein localization to chromatin, mitosis, mitotic chromosome condensation, mitotic sister chromatid cohesion, rDNA condensation	SMC loading complex, nuclear chromatin, nucleus	molecular_function		
YER147C-A	YER147C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028759]					
YER148W	SPT15	TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability [Source:SGD;Acc:S000000950]	RNA polymerase II transcriptional preinitiation complex assembly, RNA polymerase III transcriptional preinitiation complex assembly, regulation of transcription, DNA-dependent, transcription from RNA polymerase I promoter, transcription from RNA polymerase III promoter, transcription initiation from RNA polymerase II promoter, transposon integration	RNA polymerase I core factor complex, RNA polymerase I upstream activating factor complex, nucleus, transcription factor TFIID complex, transcription factor TFIIIB complex	DNA bending activity, DNA binding, binding, chromatin binding, sequence-specific DNA binding		
YER148W-A	YER148W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028760]					
YER149C	PEA2	Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth [Source:SGD;Acc:S000000951]	Rho protein signal transduction, actin filament organization, bipolar cellular bud site selection, establishment of cell polarity, filamentous growth, pseudohyphal growth, regulation of initiation of mating projection growth, regulation of termination of mating projection growth	actin cap, mating projection tip, polarisome	cytoskeletal regulatory protein binding		
YER150W	SPI1	GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p [Source:SGD;Acc:S000000952]	response to acid	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YER151C	UBP3	Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity [Source:SGD;Acc:S000000953]	protein deubiquitination, regulation of ER to Golgi vesicle-mediated transport, ribophagy, ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity, hydrolase activity, mRNA binding, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YER152C	YER152C	Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene [Source:SGD;Acc:S000000954]	biological_process, biosynthetic process	cytoplasm, nucleus	2-aminoadipate transaminase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity, transferase activity, transferring nitrogenous groups		
YER152W-A	YER152W-A	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028761]					
YER153C	PET122	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane [Source:SGD;Acc:S000000955]	positive regulation of mitochondrial translation, regulation of translation, translational initiation	membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion	translation initiation factor activity, translation regulator activity		
YER154W	OXA1	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals [Source:SGD;Acc:S000000956]	mitochondrial proton-transporting ATP synthase complex assembly, protein insertion into membrane, protein insertion into mitochondrial membrane from inner side	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	membrane insertase activity, ribosome binding		
YER155C	BEM2	Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence [Source:SGD;Acc:S000000957]	actin cytoskeleton organization, budding cell bud growth, establishment of cell polarity, fungal-type cell wall organization, microtubule cytoskeleton organization, negative regulation of Rho protein signal transduction, regulation of small GTPase mediated signal transduction, signal transduction, small GTPase mediated signal transduction	cell cortex, cellular bud tip, cytoplasm, incipient cellular bud site, intracellular, mating projection tip, mitochondrion, plasma membrane	GTPase activator activity, Rho GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding		
YER156C	YER156C	Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 [Source:SGD;Acc:S000000958]	biological_process	cytoplasm, nucleus	molecular_function		
YER157W	COG3	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000000959]	CVT pathway, ER to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, macroautophagy, peroxisome degradation, protein transport, retrograde transport, vesicle recycling within Golgi, transport	Golgi apparatus, Golgi membrane, Golgi transport complex, cis-Golgi network, membrane, peripheral to membrane of membrane fraction, soluble fraction	protein transporter activity		
YER158C	YER158C	Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000000960]	biological_process	cellular_component	molecular_function		
YER158W-A	YER158W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028624]					
YER159C	BUR6	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha [Source:SGD;Acc:S000000961]	negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter	intracellular, negative cofactor 2 complex, nucleus	DNA binding, sequence-specific DNA binding, transcription coactivator activity, transcription corepressor activity		
YER159C-A	YER159C-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007403]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YER160C	YER160C	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000000962]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YER161C	SPT2	Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins [Source:SGD;Acc:S000000963]	RNA polyadenylation, chromatin organization, negative regulation of transcription from RNA polymerase II promoter, transcription elongation from RNA polymerase II promoter	nucleus	DNA binding, DNA secondary structure binding		
YER162C	RAD4	Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins [Source:SGD;Acc:S000000964]	DNA repair, nucleotide-excision repair, proteasomal ubiquitin-dependent protein catabolic process, response to DNA damage stimulus	cytosol, nucleotide-excision repair factor 2 complex, nucleus	DNA binding, damaged DNA binding		
YER163C	YER163C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle; weak similarity to bacterial cation transport protein [Source:SGD;Acc:S000000965]	biological_process	cytoplasm, nucleus	molecular_function		
YER164W	CHD1	Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes [Source:SGD;Acc:S000000966]	chromatin assembly or disassembly, chromatin modification, chromatin remodeling, nucleosome positioning, positive regulation of transcription from RNA polymerase II promoter, transcription elongation from RNA polymerase II promoter	SAGA complex, SLIK (SAGA-like) complex, chromatin, mitochondrion, nucleus, transcription elongation factor complex	ATP binding, ATPase activity, DNA binding, chromatin binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding		
YER165C-A	YER165C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DNF1/YER166W [Source:SGD;Acc:S000028762]					
YER165W	PAB1	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G [Source:SGD;Acc:S000000967]	mRNA processing, mRNA transport, regulation of nuclear-transcribed mRNA poly(A) tail shortening, regulation of translation, regulation of translational initiation, transport	cytoplasm, nucleus, ribosome, stress granule	RNA binding, nucleic acid binding, nucleotide binding, poly(A) RNA binding		
YER166W	DNF1	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase [Source:SGD;Acc:S000000968]	ATP biosynthetic process, endocytosis, establishment or maintenance of cell polarity, intracellular protein transport, phospholipid translocation, phospholipid transport	integral to membrane, membrane, mitochondrion, plasma membrane	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, magnesium ion binding, nucleotide binding, phospholipid-translocating ATPase activity		
YER167W	BCK2	Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations [Source:SGD;Acc:S000000969]	G1/S transition of mitotic cell cycle, positive regulation of gene expression, regulation of cell cycle	cytoplasm, nucleus	molecular_function		
YER168C	CCA1	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites [Source:SGD;Acc:S000000970]	RNA processing, tRNA 3'-terminal CCA addition	cytoplasm, mitochondrial matrix, mitochondrion, nucleus	ATP binding, RNA binding, nucleotide binding, nucleotidyltransferase activity, tRNA adenylyltransferase activity, transferase activity		
YER169W	RPH1	JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway [Source:SGD;Acc:S000000971]	DNA repair, histone demethylation, negative regulation of transcription from RNA polymerase II promoter	intracellular, nucleus	DNA binding, histone demethylase activity (H3-K36 specific), histone demethylase activity (H3-K4 specific), histone demethylase activity (H3-K9 specific), metal ion binding, nucleic acid binding, protein binding, sequence-specific DNA binding, zinc ion binding		
YER170W	ADK2	Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background [Source:SGD;Acc:S000000972]	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, nucleotide metabolic process	mitochondrial inner membrane, mitochondrion	ATP binding, adenylate kinase activity, kinase activity, nucleobase, nucleoside, nucleotide kinase activity, nucleoside triphosphate adenylate kinase activity, nucleotide binding, nucleotide kinase activity, phosphotransferase activity, phosphate group as acceptor, transferase activity		
YER171W	RAD3	5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance [Source:SGD;Acc:S000000973]	DNA repair, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, nucleotide-excision repair, nucleotide-excision repair, DNA incision, phosphorylation of RNA polymerase II C-terminal domain, regulation of mitotic recombination, regulation of transposition, RNA-mediated, response to DNA damage stimulus	core TFIIH complex, holo TFIIH complex, nucleotide-excision repair factor 3 complex, nucleus	ATP binding, ATP-dependent 5'-3' DNA helicase activity, ATP-dependent DNA helicase activity, ATP-dependent helicase activity, DNA binding, damaged DNA binding, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, iron-sulfur cluster binding, metal ion binding, nucleic acid binding, nucleotide binding		
YER172C	BRR2	RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD [Source:SGD;Acc:S000000974]	RNA splicing, auxin biosynthetic process, mRNA processing, spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	U4/U6 x U5 tri-snRNP complex, U5 snRNP, nucleus, spliceosomal complex	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YER172C-A	YER172C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028763]					
YER173W	RAD24	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein [Source:SGD;Acc:S000000975]	DNA damage checkpoint, DNA repair, cell cycle, nucleotide-excision repair, reciprocal meiotic recombination, response to DNA damage stimulus	Rad17 RFC-like complex, nucleus	ATP binding, DNA clamp loader activity, nucleotide binding		
YER174C	GRX4	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000000976]	cell redox homeostasis, cellular iron ion homeostasis, cellular response to oxidative stress	nucleus	2 iron, 2 sulfur cluster binding, disulfide oxidoreductase activity, electron carrier activity, iron-sulfur cluster binding, metal ion binding, protein disulfide oxidoreductase activity		
YER175C	TMT1	Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle [Source:SGD;Acc:S000000977]	biological_process, metabolic process	cytoplasm, cytosol	methyltransferase activity, trans-aconitate 3-methyltransferase activity, transferase activity		
YER175W-A	YER175W-A	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028625]	biological_process	cellular_component	molecular_function		
YER176W	ECM32	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes [Source:SGD;Acc:S000000978]	regulation of translational termination	cytoplasm, polysome	ATP binding, DNA binding, DNA helicase activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleotide binding		
YER177W	BMH1	14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling [Source:SGD;Acc:S000000979]	DNA damage checkpoint, Ras protein signal transduction, ascospore formation, fungal-type cell wall chitin biosynthetic process, glycogen metabolic process, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, pseudohyphal growth, signal transduction involved in filamentous growth	nucleus, plasma membrane enriched fraction	DNA replication origin binding, phosphoserine binding, protein domain specific binding		
YER178W	PDA1	E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose [Source:SGD;Acc:S000000980]	acetyl-CoA biosynthetic process from pyruvate, glycolysis, metabolic process, oxidation-reduction process	intracellular membrane-bounded organelle, mitochondrial matrix, mitochondrial nucleoid, mitochondrial pyruvate dehydrogenase complex, mitochondrion	oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, pyruvate dehydrogenase (acetyl-transferring) activity		
YER179W	DMC1	Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein [Source:SGD;Acc:S000000981]	DNA metabolic process, auxin biosynthetic process, cell cycle, meiosis, meiotic joint molecule formation, reciprocal meiotic recombination, sporulation resulting in formation of a cellular spore	condensed nuclear chromosome, nucleus	ATP binding, DNA binding, DNA-dependent ATPase activity, double-stranded DNA binding, nucleoside-triphosphatase activity, nucleotide binding, single-stranded DNA binding		
YER180C	ISC10	Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells [Source:SGD;Acc:S000000982]	cell cycle, meiosis, sporulation resulting in formation of a cellular spore	cellular_component	molecular_function		
YER180C-A	SLO1	Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO [Source:SGD;Acc:S000028437]	protein targeting to vacuole	cytoplasm	small GTPase regulator activity		
YER181C	YER181C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000983]					
YER182W	FMP10	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000984]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YER183C	FAU1	5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis [Source:SGD;Acc:S000000985]	folic acid-containing compound biosynthetic process	mitochondrion	5-formyltetrahydrofolate cyclo-ligase activity, ATP binding, ligase activity, nucleotide binding		
YER184C	YER184C	Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source [Source:SGD;Acc:S000000986]	biological_process, regulation of transcription, DNA-dependent	cellular_component, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YER185W	PUG1	Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins [Source:SGD;Acc:S000000987]	heme transport, response to stress	integral to membrane, membrane, plasma membrane	molecular_function		
YER186C	YER186C	Putative protein of unknown function [Source:SGD;Acc:S000000988]	biological_process	cellular_component	molecular_function		
YER187W	YER187W	Putative protein of unknown function; induced in respiratory-deficient cells [Source:SGD;Acc:S000000989]	biological_process	cellular_component	molecular_function		
YER188C-A	YER188C-A	Putative protein of unknown function [Source:SGD;Acc:S000028764]	biological_process	cellular_component	molecular_function		
YER188W	YER188W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p [Source:SGD;Acc:S000000990]					
YER189W	YER189W	Putative protein of unknown function [Source:SGD;Acc:S000000991]	biological_process	cellular_component	molecular_function		
YER190C-A	YER190C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-2/YER190W; identified by gene-trapping, expression analysis, and homology [Source:SGD;Acc:S000028626]					
YER190C-B	YER190C-B	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028627]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YER190W	YRF1-2	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000000992]	auxin biosynthetic process, telomere maintenance via recombination	nucleus	ATP binding, ATP-dependent helicase activity, DNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YFL001W	DEG1	tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability [Source:SGD;Acc:S000001895]	RNA modification, pseudouridine synthesis, tRNA processing, tRNA pseudouridine synthesis	cytoplasm, nucleus	RNA binding, isomerase activity, pseudouridine synthase activity		
YFL002C	SPB4	Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients [Source:SGD;Acc:S000001894]	rRNA processing, ribosomal large subunit assembly, ribosome biogenesis	nucleolus, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YFL002W-A	YFL002W-A	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000002962]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YFL002W-B	YFL002W-B	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007404]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YFL003C	MSH4	Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein [Source:SGD;Acc:S000001891]	meiosis, mismatch repair, reciprocal meiotic recombination	nuclear chromosome	ATP binding, DNA binding, mismatched DNA binding, nucleotide binding		
YFL004W	VTC2	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion [Source:SGD;Acc:S000001890]	microautophagy, polyphosphate metabolic process, protein localization, vacuolar transport, vacuole fusion, non-autophagic	endoplasmic reticulum, integral to membrane, membrane, vacuolar membrane, vacuolar transporter chaperone complex, vacuole	molecular_function		
YFL005W	SEC4	Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane [Source:SGD;Acc:S000001889]	Golgi to plasma membrane transport, ascospore-type prospore formation, autophagy, bipolar cellular bud site selection, cytokinesis, exocytosis, membrane addition at site of cytokinesis, protein transport, small GTPase mediated signal transduction, transport, vesicle fusion	actin cap, cytoplasm, cytoplasmic vesicle, incipient cellular bud site, membrane, mitochondrial outer membrane, mitochondrion, plasma membrane, plasma membrane enriched fraction, transport vesicle, transport vesicle membrane, vesicle	GTP binding, GTPase activity, nucleotide binding		
YFL007W	BLM10	Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 [Source:SGD;Acc:S000001887]	proteasome assembly, protein catabolic process	cytoplasm, nucleus, proteasome complex, proteasome core complex	binding, molecular_function		
YFL008W	SMC1	Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure [Source:SGD;Acc:S000001886]	cell cycle, cell division, chromosome organization, double-strand break repair, mitosis, mitotic sister chromatid cohesion, mitotic sister chromatid segregation	chromosome, nuclear mitotic cohesin complex, nucleus	AT DNA binding, ATP binding, ATPase activity, DNA secondary structure binding, double-stranded DNA binding, nucleotide binding, protein binding		
YFL009W	CDC4	F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p [Source:SGD;Acc:S000001885]	G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, meiosis, mitosis, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, sporulation resulting in formation of a cellular spore	SCF ubiquitin ligase complex, nuclear SCF ubiquitin ligase complex, nuclear matrix, nucleus	protein binding, ubiquitin binding, ubiquitin-protein ligase activity		
YFL010C	WWM1	WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 [Source:SGD;Acc:S000001884]	biological_process	cytoplasm, integral to membrane, membrane, mitochondrion, nucleus	molecular_function, protein binding		
YFL010W-A	AUA1	Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease [Source:SGD;Acc:S000001955]	amino acid transport	cellular_component	molecular_function		
YFL011W	HXT10	Putative hexose transporter, expressed at low levels and expression is repressed by glucose [Source:SGD;Acc:S000001883]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrion, plasma membrane	fructose transmembrane transporter activity, galactose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YFL012W	YFL012W	Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin [Source:SGD;Acc:S000001882]	biological_process	cellular_component	molecular_function		
YFL012W-A	YFL012W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C [Source:SGD;Acc:S000002964]					
YFL013C	IES1	Subunit of the INO80 chromatin remodeling complex [Source:SGD;Acc:S000001881]	nucleosome mobilization	Ino80 complex, nucleus	molecular_function		
YFL013W-A	YFL013W-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028628]					
YFL014W	HSP12	Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; regulated by HOG and Ras-Pka pathways [Source:SGD;Acc:S000001880]	cell adhesion, cellular response to heat, cellular response to osmotic stress, cellular response to oxidative stress, plasma membrane organization, response to stress	cytoplasm, cytosol, endosome, nucleus, plasma membrane, plasma membrane enriched fraction	lipid binding		
YFL015C	YFL015C	Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene [Source:SGD;Acc:S000001879]					
YFL015W-A	YFL015W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028765]					
YFL016C	MDJ1	Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones [Source:SGD;Acc:S000001878]	'de novo' protein folding, misfolded or incompletely synthesized protein catabolic process, mitochondrial genome maintenance, protein folding, protein refolding, response to heat, response to stress	extrinsic to mitochondrial inner membrane, mitochondrial matrix, mitochondrion	ATP binding, ATPase activator activity, heat shock protein binding, metal ion binding, unfolded protein binding		
YFL017C	GNA1	Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA [Source:SGD;Acc:S000001877]	UDP-N-acetylglucosamine biosynthetic process, metabolic process	cytoplasm, nucleus	N-acetyltransferase activity, acyltransferase activity, glucosamine 6-phosphate N-acetyltransferase activity, transferase activity		
YFL017W-A	SMX2	Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G [Source:SGD;Acc:S000002965]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, nucleus, ribonucleoprotein complex	RNA binding, molecular_function		
YFL018C	LPD1	Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes [Source:SGD;Acc:S000001876]	2-oxoglutarate metabolic process, L-serine biosynthetic process, cell redox homeostasis, glycine catabolic process, hydrogen peroxide metabolic process, isoleucine catabolic process, leucine catabolic process, oxidation-reduction process, pyruvate metabolic process, valine catabolic process	cytoplasm, glycine cleavage complex, mitochondrial matrix, mitochondrial nucleoid, mitochondrial oxoglutarate dehydrogenase complex, mitochondrion	dihydrolipoyl dehydrogenase activity, flavin adenine dinucleotide binding, glycine dehydrogenase (decarboxylating) activity, oxidoreductase activity, oxoglutarate dehydrogenase (succinyl-transferring) activity, pyruvate dehydrogenase activity		
YFL019C	YFL019C	Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene [Source:SGD;Acc:S000001875]					
YFL020C	PAU5	Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme [Source:SGD;Acc:S000001874]	biological_process, response to stress	integral to membrane, integral to membrane of membrane fraction, membrane, soluble fraction	molecular_function		
YFL021C-A	YFL021C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028766]					
YFL021W	GAT1	Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p [Source:SGD;Acc:S000001873]	nitrogen catabolite activation of transcription, regulation of transcription, DNA-dependent	cytosol, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YFL022C	FRS2	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar [Source:SGD;Acc:S000001872]	phenylalanyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, phenylalanine-tRNA ligase complex	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, phenylalanine-tRNA ligase activity, tRNA binding		
YFL023W	BUD27	Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding [Source:SGD;Acc:S000001871]	formation of translation preinitiation complex, protein folding	cytoplasm, cytosolic ribosome, prefoldin complex	molecular_function, unfolded protein binding		
YFL024C	EPL1	Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb [Source:SGD;Acc:S000001870]	DNA repair, cell cycle, histone acetylation, regulation of transcription from RNA polymerase II promoter, response to DNA damage stimulus	NuA4 histone acetyltransferase complex, Piccolo NuA4 histone acetyltransferase complex, nucleus	histone acetyltransferase activity		
YFL025C	BST1	GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules [Source:SGD;Acc:S000001869]	ER to Golgi vesicle-mediated transport, ER-associated protein catabolic process, GPI anchor metabolic process, protein retention in ER lumen, protein transport, transport, vesicle organization	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	hydrolase activity, phosphatidylinositol deacylase activity		
YFL026W	STE2	Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells [Source:SGD;Acc:S000001868]	G-protein coupled receptor protein signaling pathway, cell projection assembly, cytogamy, pheromone-dependent signal transduction involved in conjugation with cellular fusion, protein homooligomerization, response to pheromone, signal transduction	integral to membrane, integral to plasma membrane, membrane, membrane fraction	G-protein coupled receptor activity, mating-type alpha-factor pheromone receptor activity, mating-type factor pheromone receptor activity, receptor activity, signal transducer activity		
YFL027C	GYP8	GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport [Source:SGD;Acc:S000001867]	regulation of Rab GTPase activity, vesicle-mediated transport	intracellular	GTPase activator activity, Rab GTPase activator activity		
YFL028C	CAF16	Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator [Source:SGD;Acc:S000001866]	regulation of transcription from RNA polymerase II promoter, transport	CCR4-NOT complex, cytoplasm, nucleus	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding		
YFL029C	CAK1	Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases [Source:SGD;Acc:S000001865]	G1 phase of mitotic cell cycle, G2/M transition of mitotic cell cycle, meiosis, protein phosphorylation	cytoplasm	ATP binding, cyclin-dependent protein kinase activating kinase activity, cyclin-dependent protein kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YFL030W	AGX1	Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases [Source:SGD;Acc:S000001864]	glycine biosynthetic process, by transamination of glyoxylate, metabolic process	mitochondrion	alanine-glyoxylate transaminase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity		
YFL031C-A	YFL031C-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps HAC1/YFL031W; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028629]					
YFL031W	HAC1	Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis [Source:SGD;Acc:S000001863]	endoplasmic reticulum unfolded protein response, phospholipid metabolic process, positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, positive regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to unfolded protein	nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YFL032W	YFL032W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene [Source:SGD;Acc:S000001862]					
YFL033C	RIM15	Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase [Source:SGD;Acc:S000001861]	age-dependent response to oxidative stress involved in chronological cell aging, meiosis, protein phosphorylation, regulation of meiosis, regulation of transcription, DNA-dependent, response to stress, two-component signal transduction system (phosphorelay)	cytoplasm, nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, two-component response regulator activity		
YFL034C-A	RPL22B	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein [Source:SGD;Acc:S000006436]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YFL034C-B	MOB2	Component of the RAM signaling network, that activates the Cbk1p kinase, thereby facilitating the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p [Source:SGD;Acc:S000001859]	budding cell apical bud growth, cell cycle, cell division, establishment or maintenance of cell polarity, mitosis, protein phosphorylation, regulation of exit from mitosis	cellular bud, cellular bud neck, cellular bud tip, cytoplasm, mating projection tip, nucleus	protein kinase activator activity		
YFL034W	YFL034W	Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk [Source:SGD;Acc:S000001860]	biological_process	integral to membrane, membrane	molecular_function		
YFL036W	RPO41	Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition [Source:SGD;Acc:S000001858]	aerobic respiration, mitochondrial genome maintenance, transcription from mitochondrial promoter	mitochondrial DNA-directed RNA polymerase complex, mitochondrial matrix, mitochondrial nucleoid, mitochondrion	DNA binding, DNA-directed RNA polymerase activity, nucleotidyltransferase activity, transferase activity		
YFL037W	TUB2	Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules [Source:SGD;Acc:S000001857]	homologous chromosome segregation, microtubule-based movement, microtubule-based process, mitotic sister chromatid segregation, nuclear migration along microtubule, nuclear migration involved in conjugation with cellular fusion, protein polymerization, response to antibiotic	cytoplasm, cytoplasmic microtubule, cytoskeleton, kinetochore microtubule, microtubule, nuclear microtubule, polar microtubule, protein complex, spindle pole body, tubulin complex	GTP binding, GTPase activity, nucleotide binding, structural constituent of cytoskeleton, structural molecule activity		
YFL038C	YPT1	Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) [Source:SGD;Acc:S000001856]	COPII-coated vesicle budding, CVT pathway, ER to Golgi vesicle-mediated transport, Golgi vesicle budding, Golgi vesicle docking, SNARE complex disassembly, early endosome to Golgi transport, endocytic recycling, macroautophagy, protein complex assembly, protein transport, retrograde vesicle-mediated transport, Golgi to ER, small GTPase mediated signal transduction, transport, vesicle-mediated transport	Golgi apparatus, Golgi membrane, Golgi stack, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion, pre-autophagosomal structure, trans-Golgi network	GTP binding, GTPase activity, SNARE binding, nucleotide binding		
YFL039C	ACT1	Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions [Source:SGD;Acc:S000001855]	DNA repair, actin filament reorganization involved in cell cycle, ascospore wall assembly, budding cell isotropic bud growth, cellular response to oxidative stress, chronological cell aging, contractile ring contraction involved in cell cycle cytokinesis, cytokinesis, endocytosis, establishment of cell polarity, establishment of mitotic spindle orientation, exocytosis, fungal-type cell wall organization, histone acetylation, mitochondrion inheritance, protein secretion, regulation of transcription from RNA polymerase II promoter, vacuole inheritance, vesicle transport along actin filament	Ino80 complex, NuA4 histone acetyltransferase complex, Swr1 complex, actin cortical patch, actin filament, actin filament bundle, cellular bud neck contractile ring, cytoplasm, cytoskeleton, histone acetyltransferase complex	ATP binding, nucleotide binding, structural constituent of cytoskeleton		
YFL040W	YFL040W	Putative transporter, member of the sugar porter family; YFL040W is not an essential gene [Source:SGD;Acc:S000001854]	transmembrane transport, transport	integral to membrane, membrane	substrate-specific transmembrane transporter activity, transporter activity		
YFL041W	FET5	Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport [Source:SGD;Acc:S000001853]	ion transport, iron ion transport, oxidation-reduction process, transport	fungal-type vacuole membrane, integral to membrane, membrane, plasma membrane	copper ion binding, ferroxidase activity, metal ion binding, oxidoreductase activity		
YFL041W-A	YFL041W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028547]	biological_process	cellular_component	molecular_function		
YFL042C	YFL042C	Putative protein of unknown function; YFL042C is not an essential gene [Source:SGD;Acc:S000001852]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YFL044C	OTU1	Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family [Source:SGD;Acc:S000001850]	protein deubiquitination	cytoplasm, intracellular, nucleus	cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, ubiquitin-specific protease activity, zinc ion binding		
YFL045C	SEC53	Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen [Source:SGD;Acc:S000001849]	mannose biosynthetic process, metabolic process, protein targeting to ER	cytoplasm, cytosol	catalytic activity, isomerase activity, phosphomannomutase activity		
YFL046W	FMP32	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001848]	biological_process	integral to membrane, membrane, mitochondrion	molecular_function		
YFL047W	RGD2	GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p [Source:SGD;Acc:S000001847]	intracellular signal transduction, signal transduction, small GTPase mediated signal transduction	cellular bud neck, cytoplasm, intracellular	GTPase activator activity, Rho GTPase activator activity		
YFL048C	EMP47	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport [Source:SGD;Acc:S000001846]	ER to Golgi vesicle-mediated transport	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function, sugar binding		
YFL049W	SWP82	Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p [Source:SGD;Acc:S000001845]	ER-associated protein catabolic process, chromatin modification, chromatin remodeling, nucleosome mobilization	SWI/SNF complex, nucleus			
YFL050C	ALR2	Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000001844]	cation transport, magnesium ion transport, metal ion transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	inorganic cation transmembrane transporter activity, metal ion transmembrane transporter activity		
YFL051C	YFL051C	Putative protein of unknown function; YFL051C is not an essential gene [Source:SGD;Acc:S000001843]	biological_process	cellular_component, integral to membrane, membrane, plasma membrane	molecular_function		
YFL052W	YFL052W	Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity [Source:SGD;Acc:S000001842]	biological_process, regulation of transcription, DNA-dependent	cellular_component, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YFL053W	DAK2	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation [Source:SGD;Acc:S000001841]	glycerol catabolic process, glycerol metabolic process, response to stress	cellular_component	ATP binding, glycerone kinase activity, kinase activity, nucleotide binding, transferase activity		
YFL054C	YFL054C	Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol [Source:SGD;Acc:S000001840]	transmembrane transport, transport, water transport	integral to membrane, membrane	glycerol transmembrane transporter activity, transporter activity, water channel activity		
YFL055W	AGP3	Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000001839]	amino acid transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	amino acid transmembrane transporter activity		
YFL056C	AAD6	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response; expression induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000001838]	cellular aldehyde metabolic process, oxidation-reduction process	cellular_component	aryl-alcohol dehydrogenase activity, oxidoreductase activity		
YFL057C	AAD16	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role [Source:SGD;Acc:S000001837]	cellular aldehyde metabolic process, oxidation-reduction process	cellular_component	aryl-alcohol dehydrogenase activity, oxidoreductase activity		
YFL058W	THI5	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 [Source:SGD;Acc:S000001836]	thiamine biosynthetic process	cellular_component	molecular_function		
YFL059W	SNZ3	Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3 [Source:SGD;Acc:S000001835]	metabolic process, pyridoxal phosphate biosynthetic process, pyridoxine biosynthetic process, pyridoxine metabolic process, thiamine biosynthetic process	cellular_component	catalytic activity, protein binding		
YFL060C	SNO3	Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin [Source:SGD;Acc:S000001834]	glutamine metabolic process, pyridoxine biosynthetic process, pyridoxine metabolic process, thiamine biosynthetic process	cellular_component	molecular_function, transferase activity		
YFL061W	DDI2	Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants [Source:SGD;Acc:S000001833]	biological_process	cellular_component	catalytic activity, lyase activity, molecular_function		
YFL062W	COS4	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000001832]	biological_process	fungal-type vacuole, integral to membrane, membrane	molecular_function		
YFL063W	YFL063W	Dubious open reading frame, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001831]					
YFL064C	YFL064C	Putative protein of unknown function [Source:SGD;Acc:S000001830]	biological_process	cellular_component	molecular_function		
YFL065C	YFL065C	Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000001829]	biological_process	cellular_component	molecular_function		
YFL066C	YFL066C	Helicase-like protein encoded within the telomeric Y' element; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000001828]	biological_process	cellular_component	ATP binding, ATP-dependent helicase activity, helicase activity, hydrolase activity, molecular_function, nucleic acid binding, nucleotide binding		
YFL067W	YFL067W	Protein of unknown function, down-regulated at low calcium levels [Source:SGD;Acc:S000001827]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YFL068W	YFL068W	Putative protein of unknown function [Source:SGD;Acc:S000001826]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YFR001W	LOC1	Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles [Source:SGD;Acc:S000001897]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), intracellular mRNA localization, mRNA transport, ribosomal large subunit biogenesis, ribosome biogenesis, transport	nucleolus, nucleus, preribosome, large subunit precursor	mRNA binding		
YFR002W	NIC96	Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p [Source:SGD;Acc:S000001898]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein import into nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	Nic96 complex, membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YFR003C	YPI1	Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen [Source:SGD;Acc:S000001899]	glycogen metabolic process, protein dephosphorylation	nucleus	protein phosphatase inhibitor activity		
YFR004W	RPN11	Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes [Source:SGD;Acc:S000001900]	mitochondrial fission, peroxisome fission, proteasomal ubiquitin-dependent protein catabolic process, protein deubiquitination	cytosol, mitochondrion, nucleus, proteasome complex, proteasome regulatory particle, lid subcomplex, proteasome storage granule	metallopeptidase activity, protein binding, ubiquitin-specific protease activity		
YFR005C	SAD1	Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle [Source:SGD;Acc:S000001901]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome, ubiquitin-dependent protein catabolic process	nucleus, ribonucleoprotein complex, spliceosomal complex	metal ion binding, molecular_function, ubiquitin thiolesterase activity, zinc ion binding		
YFR006W	YFR006W	Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene [Source:SGD;Acc:S000001902]	biological_process, cellular process, proteolysis	cytoplasm, integral to membrane, membrane	aminopeptidase activity, hydrolase activity, manganese ion binding, metal ion binding, metalloexopeptidase activity, molecular_function		
YFR007W	YFH7	Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases [Source:SGD;Acc:S000001903]	phosphorylation	cellular_component	ATP binding, ATPase activity, kinase activity		
YFR008W	FAR7	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p [Source:SGD;Acc:S000001904]	cell cycle, re-entry into mitotic cell cycle after pheromone arrest	cellular_component	molecular_function		
YFR009W	GCN20	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA [Source:SGD;Acc:S000001905]	regulation of translational elongation	cytosol, cytosolic ribosome	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding		
YFR009W-A	YFR009W-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YFR009W; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028823]					
YFR010W	UBP6	Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance [Source:SGD;Acc:S000001906]	protein deubiquitination, ubiquitin-dependent protein catabolic process	proteasome complex, proteasome regulatory particle	cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YFR010W-A	YFR010W-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YFR011C; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028824]					
YFR011C	AIM13	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria; null mutant displays reduced respiratory growth and reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000001907]	biological_process	cytoplasm, mitochondrion	molecular_function		
YFR012W	YFR012W	Putative protein of unknown function [Source:SGD;Acc:S000001908]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YFR012W-A	YFR012W-A	Putative protein of unknown function; identified by homology [Source:SGD;Acc:S000007606]	biological_process	cellular_component	molecular_function		
YFR013W	IOC3	Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing [Source:SGD;Acc:S000001909]	chromatin remodeling	ISW1 complex, nucleus	ATPase activity, DNA binding, nucleosome binding		
YFR014C	CMK1	Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II [Source:SGD;Acc:S000001910]	protein phosphorylation, signal transduction	cytoplasm	ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YFR015C	GSY1	Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase [Source:SGD;Acc:S000001911]	glycogen biosynthetic process	cytoplasm, mitochondrion	catalytic activity, glycogen (starch) synthase activity, transferase activity, transferase activity, transferring glycosyl groups		
YFR016C	YFR016C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene [Source:SGD;Acc:S000001912]	biological_process, cell redox homeostasis	cellular bud, cytoplasm	electron carrier activity, molecular_function, protein disulfide oxidoreductase activity		
YFR017C	YFR017C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene [Source:SGD;Acc:S000001913]	biological_process	cytoplasm	molecular_function		
YFR018C	YFR018C	Putative protein of unknown function [Source:SGD;Acc:S000001914]	biological_process, proteolysis	cellular_component	acyltransferase activity, molecular_function, peptidase activity, transferase activity		
YFR019W	FAB1	1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis [Source:SGD;Acc:S000001915]	cellular protein metabolic process, phosphatidylinositol metabolic process, phosphatidylinositol phosphorylation	PAS complex, endosome, endosome membrane, fungal-type vacuole membrane, membrane, mitochondrion, vacuolar membrane, vacuole	1-phosphatidylinositol-3-phosphate 5-kinase activity, ATP binding, kinase activity, metal ion binding, nucleotide binding, phosphatidylinositol phosphate kinase activity, phosphatidylinositol-3-phosphate binding, transferase activity, zinc ion binding		
YFR020W	YFR020W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001916]					
YFR021W	ATG18	Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein [Source:SGD;Acc:S000001917]	CVT pathway, autophagy, late endosome to vacuole transport, macroautophagy, peroxisome degradation, piecemeal microautophagy of nucleus, protein transport, transport, vacuolar protein processing	PAS complex, cytosol, endosome, fungal-type vacuole membrane, membrane, pre-autophagosomal structure, pre-autophagosomal structure membrane, vacuolar membrane, vacuole	phosphatidylinositol binding, protein binding, ubiquitin binding		
YFR022W	ROG3	Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins [Source:SGD;Acc:S000001918]	ubiquitin-dependent endocytosis	cellular_component	ubiquitin protein ligase binding		
YFR023W	PES4	Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p [Source:SGD;Acc:S000001919]	biological_process	cellular_component, nucleus	RNA binding, molecular_function, nucleic acid binding, nucleotide binding		
YFR024C-A	LSB3	Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization [Source:SGD;Acc:S000002968]	actin cortical patch localization	cellular bud neck, cytoplasm, mitochondrion	molecular_function, protein binding		
YFR025C	HIS2	Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control [Source:SGD;Acc:S000001921]	cellular amino acid biosynthetic process, histidine biosynthetic process	intracellular	catalytic activity, histidinol-phosphatase activity, hydrolase activity		
YFR026C	ULI1	Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response [Source:SGD;Acc:S000001922]	endoplasmic reticulum unfolded protein response	cellular_component	molecular_function		
YFR027W	ECO1	Acetyltransferase required for sister chromatid cohesion; modifies Smc3p at DNA replication forks during S-phase; modifies Mcd1p in response to double-strand DNA breaks during G2/M; mutations in human homolog ESCO2 cause Roberts syndrome [Source:SGD;Acc:S000001923]	DNA repair, DNA replication, cell cycle, chromosome organization, double-strand break repair, establishment of mitotic sister chromatid cohesion, internal peptidyl-lysine acetylation, mitotic chromosome condensation, regulation of DNA replication, regulation of mitosis, tRNA gene clustering, telomere organization	nuclear chromatin, nuclear replication fork, nucleus	DNA-directed DNA polymerase activity, acetyltransferase activity, acyltransferase activity, chromatin binding, damaged DNA binding, metal ion binding, transferase activity		
YFR028C	CDC14	Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit [Source:SGD;Acc:S000001924]	cell cycle, dephosphorylation, mitotic cell cycle, nucleolus organization, protein dephosphorylation, regulation of exit from mitosis	RENT complex, cytoplasm, nucleolus, nucleus, spindle pole body	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity		
YFR029W	PTR3	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes [Source:SGD;Acc:S000001925]	response to amino acid stimulus	extrinsic to plasma membrane, membrane, plasma membrane	molecular_function, protein binding		
YFR030W	MET10	Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide [Source:SGD;Acc:S000001926]	cellular amino acid biosynthetic process, cysteine biosynthetic process, electron transport chain, metabolic process, methionine biosynthetic process, oxidation-reduction process, sulfate assimilation, transport	sulfite reductase complex (NADPH)	catalytic activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, sulfite reductase (NADPH) activity		
YFR031C	SMC2	Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus [Source:SGD;Acc:S000001927]	cell cycle, cell division, chromosome condensation, chromosome organization, mitosis, mitotic chromosome condensation, mitotic sister chromatid segregation, tRNA gene clustering	chromosome, cytoplasm, mitochondrion, nuclear condensin complex, nucleus	AT DNA binding, ATP binding, ATPase activity, DNA secondary structure binding, double-stranded DNA binding, nucleotide binding, protein binding		
YFR031C-A	RPL2A	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins [Source:SGD;Acc:S000002104]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YFR032C	RRT5	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation [Source:SGD;Acc:S000001928]	biological_process	cellular_component	RNA binding, molecular_function, nucleic acid binding, nucleotide binding		
YFR032C-A	RPL29	Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate [Source:SGD;Acc:S000006437]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YFR032C-B	YFR032C-B	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028630]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YFR033C	QCR6	Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1 [Source:SGD;Acc:S000001929]	aerobic respiration, electron transport chain, mitochondrial electron transport, ubiquinol to cytochrome c, transport	membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex III, mitochondrion, respiratory chain	ubiquinol-cytochrome-c reductase activity		
YFR034C	PHO4	Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability [Source:SGD;Acc:S000001930]	cellular response to phosphate starvation, chromatin remodeling, phosphate metabolic process, positive regulation of phosphate metabolic process, positive regulation of transcription from RNA polymerase II promoter	cytoplasm, nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YFR034W-A	YFR034W-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YFR035C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028631]					
YFR035C	YFR035C	Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein [Source:SGD;Acc:S000001931]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YFR036W	CDC26	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000001932]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, cyclin catabolic process, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, protein ubiquitination	anaphase-promoting complex, nucleus	ubiquitin-protein ligase activity		
YFR036W-A	YFR036W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RSC8 [Source:SGD;Acc:S000028767]					
YFR037C	RSC8	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters [Source:SGD;Acc:S000001933]	ATP-dependent chromatin remodeling, G1/S transition of mitotic cell cycle, chromatin modification, double-strand break repair via nonhomologous end joining, nucleosome disassembly, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	DNA binding, DNA-dependent ATPase activity, metal ion binding, protein binding, zinc ion binding		
YFR038W	IRC5	Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000001934]	mitotic recombination	cellular_component, nucleus	ATP binding, DNA binding, helicase activity, hydrolase activity, molecular_function, nucleic acid binding, nucleotide binding		
YFR039C	YFR039C	Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces [Source:SGD;Acc:S000001935]	biological_process	cellular_component	molecular_function		
YFR040W	SAP155	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p [Source:SGD;Acc:S000001936]	G1/S transition of mitotic cell cycle, cell cycle	cytoplasm	protein serine/threonine phosphatase activity		
YFR041C	ERJ5	Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response [Source:SGD;Acc:S000001937]	protein folding	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	heat shock protein binding, molecular_function		
YFR042W	KEG1	Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability [Source:SGD;Acc:S000001938]	1,6-beta-glucan biosynthetic process, cellular cell wall organization, chromosome organization	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YFR043C	IRC6	Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000001939]	biological_process	cellular_component	molecular_function		
YFR044C	DUG1	Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) [Source:SGD;Acc:S000001940]	glutathione catabolic process, metabolic process	cytoplasm, mitochondrion, ribosome	dipeptidase activity, hydrolase activity, metal ion binding, metallodipeptidase activity, metallopeptidase activity, omega peptidase activity, peptidase activity, tripeptidase activity		
YFR045W	YFR045W	Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white [Source:SGD;Acc:S000001941]	transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, transporter activity		
YFR046C	CNN1	Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1. [Source:SGD;Acc:S000001942]	cell cycle, cell division, chromosome segregation, mitosis	chromosome, centromeric region, condensed chromosome kinetochore, kinetochore, nucleus	molecular_function		
YFR047C	BNA6	Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p [Source:SGD;Acc:S000001943]	NAD biosynthetic process, de novo NAD biosynthetic process from tryptophan, metabolic process, pyridine nucleotide biosynthetic process	cytoplasm, nucleus	catalytic activity, nicotinate-nucleotide diphosphorylase (carboxylating) activity, transferase activity, transferase activity, transferring glycosyl groups		
YFR048W	RMD8	Cytosolic protein required for sporulation [Source:SGD;Acc:S000001944]	biological_process, meiosis, sporulation resulting in formation of a cellular spore	cytoplasm, integral to membrane, membrane	molecular_function		
YFR049W	YMR31	Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 [Source:SGD;Acc:S000001945]	translation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YFR050C	PRE4	Beta 7 subunit of the 20S proteasome [Source:SGD;Acc:S000001946]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteasome assembly, proteolysis involved in cellular protein catabolic process	cytoplasm, endoplasmic reticulum membrane, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, molecular_function, peptidase activity, threonine-type endopeptidase activity		
YFR051C	RET2	Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER [Source:SGD;Acc:S000001947]	ER to Golgi vesicle-mediated transport, Golgi inheritance, Golgi localization, intracellular protein transport, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	COPI coated vesicle membrane, COPI vesicle coat, Golgi apparatus, Golgi membrane, clathrin adaptor complex, cytoplasm, cytoplasmic vesicle, membrane	molecular_function, protein binding		
YFR052C-A	YFR052C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028768]					
YFR052W	RPN12	Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p [Source:SGD;Acc:S000001948]	proteolysis, ubiquitin-dependent protein catabolic process	proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex, proteasome storage granule	molecular_function		
YFR053C	HXK1	Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p [Source:SGD;Acc:S000001949]	carbohydrate metabolic process, fructose import, fructose metabolic process, glucose import, glucose metabolic process, glycolysis, mannose metabolic process	cytoplasm, cytosol, mitochondrion	ATP binding, catalytic activity, hexokinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YFR054C	YFR054C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001950]					
YFR055W	IRC7	Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner [Source:SGD;Acc:S000001952]	cellular amino acid biosynthetic process, cellular amino acid metabolic process, cellular copper ion homeostasis, methionine biosynthetic process, mitotic recombination, sulfur compound metabolic process	cellular_component, cytoplasm	catalytic activity, cystathionine beta-lyase activity, lyase activity, pyridoxal phosphate binding		
YFR056C	YFR056C	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W [Source:SGD;Acc:S000001951]					
YFR057W	YFR057W	Putative protein of unknown function [Source:SGD;Acc:S000001953]	biological_process	cellular_component	molecular_function		
YGL001C	ERG26	C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis [Source:SGD;Acc:S000002969]	ergosterol biosynthetic process, lipid biosynthetic process, metabolic process, oxidation-reduction process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity, C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity, binding, catalytic activity, oxidoreductase activity, sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity		
YGL002W	ERP6	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002970]	ER to Golgi vesicle-mediated transport, protein transport, transport, vesicle-mediated transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion	molecular_function		
YGL003C	CDH1	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p [Source:SGD;Acc:S000002971]	activation of mitotic anaphase-promoting complex activity, cell cycle, cell division, cyclin catabolic process, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, negative regulation of spindle pole body separation, protein ubiquitination, regulation of cell size	anaphase-promoting complex, cytoplasm, nucleus	protein binding, protein binding, bridging, ubiquitin-protein ligase activity		
YGL004C	RPN14	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p [Source:SGD;Acc:S000002972]	proteasome regulatory particle assembly, ubiquitin-dependent protein catabolic process	cytoplasm, cytosol, nucleus, proteasome complex	molecular_function, protein binding		
YGL005C	COG7	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000002973]	CVT pathway, intra-Golgi vesicle-mediated transport, protein transport, transport	Golgi apparatus, Golgi membrane, Golgi transport complex, membrane, mitochondrion	molecular_function		
YGL006W	PMC1	Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a [Source:SGD;Acc:S000002974]	ATP biosynthetic process, calcium ion transport, cation transport, cellular calcium ion homeostasis, ion transport, metabolic process, transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, calcium ion transmembrane transporter activity, calcium-transporting ATPase activity, catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, nucleotide binding		
YGL006W-A	YGL006W-A	Putative protein of unknown function; identified by SAGE [Source:SGD;Acc:S000028769]	biological_process	cellular_component	molecular_function		
YGL007C-A	YGL007C-A	Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding [Source:SGD;Acc:S000028632]	biological_process	cellular_component	molecular_function		
YGL007W	BRP1	Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 [Source:SGD;Acc:S000002975]					
YGL008C	PMA1	Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases; Hsp30p plays a role in Pma1p regulation [Source:SGD;Acc:S000002976]	ATP biosynthetic process, cation transport, ion transport, metabolic process, proton transport, regulation of pH, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, membrane raft, mitochondrion, plasma membrane, plasma membrane enriched fraction	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, hydrogen-exporting ATPase activity, phosphorylative mechanism, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, metal ion binding, nucleotide binding		
YGL009C	LEU1	Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway [Source:SGD;Acc:S000002977]	branched chain family amino acid biosynthetic process, cellular amino acid biosynthetic process, leucine biosynthetic process, metabolic process	3-isopropylmalate dehydratase complex, soluble fraction	3-isopropylmalate dehydratase activity, 4 iron, 4 sulfur cluster binding, hydro-lyase activity, iron-sulfur cluster binding, lyase activity, metal ion binding		
YGL010W	YGL010W	Putative protein of unknown function; YGL010W is not an essential gene [Source:SGD;Acc:S000002978]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YGL011C	SCL1	Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria [Source:SGD;Acc:S000002979]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteolysis involved in cellular protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, mitochondrion, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, molecular_function, peptidase activity, threonine-type endopeptidase activity		
YGL012W	ERG4	C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol [Source:SGD;Acc:S000002980]	ergosterol biosynthetic process, lipid biosynthetic process, oxidation-reduction process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, integral to membrane, membrane	delta24(24-1) sterol reductase activity, oxidoreductase activity		
YGL013C	PDR1	Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes [Source:SGD;Acc:S000002981]	negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to drug	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YGL014C-A	YGL014C-A	Dubious open reading frame, unlikely to encode a functional protein; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028825]					
YGL014W	PUF4	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors [Source:SGD;Acc:S000002982]	loss of chromatin silencing involved in replicative cell aging, negative regulation of translation, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, protein localization	cytoplasm	RNA binding, binding, mRNA binding		
YGL015C	YGL015C	Putative protein of unknown function; null mutants accumulate cargo in the Golgi [Source:SGD;Acc:S000002983]	biological_process	cellular_component	molecular_function		
YGL016W	KAP122	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance [Source:SGD;Acc:S000002984]	protein import into nucleus, regulation of cell size	cytoplasm, nuclear pore	binding, protein transporter activity		
YGL017W	ATE1	Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway [Source:SGD;Acc:S000002985]	protein arginylation, protein modification process	cytoplasm	acyltransferase activity, arginyltransferase activity, transferase activity		
YGL018C	JAC1	Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix [Source:SGD;Acc:S000002986]	aerobic respiration, iron-sulfur cluster assembly, protein folding, response to stress	mitochondrial matrix, mitochondrion	chaperone binding, heat shock protein binding		
YGL019W	CKB1	Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases [Source:SGD;Acc:S000002987]	protein phosphorylation, regulation of transcription from RNA polymerase I promoter, regulation of transcription from RNA polymerase III promoter, response to DNA damage stimulus	UTP-C complex, protein kinase CK2 complex	protein kinase regulator activity, protein serine/threonine kinase inhibitor activity		
YGL020C	GET1	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance [Source:SGD;Acc:S000002988]	cellular calcium ion homeostasis, cellular protein localization, mitochondrion organization, protein insertion into ER membrane, response to unfolded protein, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	GET complex, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion	protein anchor		
YGL021W	ALK1	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins [Source:SGD;Acc:S000002989]	cell cycle, mitosis, protein phosphorylation, response to DNA damage stimulus	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YGL022W	STT3	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis [Source:SGD;Acc:S000002990]	protein N-linked glycosylation, protein glycosylation	integral to membrane, membrane, oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity, oligosaccharyl transferase activity, transferase activity		
YGL023C	PIB2	Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27 [Source:SGD;Acc:S000002991]	vesicle-mediated transport	late endosome, membrane, mitochondrion, vacuolar membrane, vacuole	1-phosphatidylinositol binding, metal ion binding, zinc ion binding		
YGL024W	YGL024W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF PGD1/YGL025C [Source:SGD;Acc:S000002992]					
YGL025C	PGD1	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor [Source:SGD;Acc:S000002993]	regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus			
YGL026C	TRP5	Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis [Source:SGD;Acc:S000002994]	aromatic amino acid family biosynthetic process, cellular amino acid biosynthetic process, metabolic process, tryptophan biosynthetic process, tryptophan metabolic process	cytoplasm, nucleus	catalytic activity, lyase activity, pyridoxal phosphate binding, tryptophan synthase activity		
YGL027C	CWH41	Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress [Source:SGD;Acc:S000002995]	fungal-type cell wall biogenesis, metabolic process, oligosaccharide metabolic process, protein N-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, mannosyl-oligosaccharide glucosidase activity		
YGL028C	SCW11	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p [Source:SGD;Acc:S000002996]	carbohydrate metabolic process, cellular cell wall organization, cytokinesis, completion of separation, metabolic process	cell wall, extracellular region, fungal-type cell wall	catalytic activity, cation binding, glucan endo-1,3-beta-D-glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds		
YGL029W	CGR1	Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress [Source:SGD;Acc:S000002997]	rRNA processing, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor	molecular_function		
YGL030W	RPL30	Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript [Source:SGD;Acc:S000002998]	negative regulation of nuclear mRNA splicing, via spliceosome, negative regulation of translation, rRNA processing, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, pre-mRNA 5'-splice site binding, structural constituent of ribosome		
YGL031C	RPL24A	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate [Source:SGD;Acc:S000002999]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YGL032C	AGA2	Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds [Source:SGD;Acc:S000003000]	agglutination involved in conjugation with cellular fusion, cell adhesion	fungal-type cell wall	cell adhesion molecule binding		
YGL033W	HOP2	Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair [Source:SGD;Acc:S000003001]	DNA recombination, meiosis, reciprocal meiotic recombination, synapsis	condensed nuclear chromosome, nucleus	DNA binding, double-stranded DNA binding, protein binding		
YGL034C	YGL034C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003002]					
YGL035C	MIG1	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase [Source:SGD;Acc:S000003003]	carbohydrate metabolic process, negative regulation of transcription from RNA polymerase II promoter by glucose	cytoplasm, intracellular, nuclear envelope lumen, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YGL036W	YGL036W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene [Source:SGD;Acc:S000003004]	biological_process	cytoplasm, integral to membrane, membrane	molecular_function		
YGL037C	PNC1	Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span [Source:SGD;Acc:S000003005]	chromatin silencing at rDNA, chromatin silencing at telomere, metabolic process, nicotinate nucleotide salvage, pyridine nucleotide biosynthetic process, replicative cell aging	cytoplasm, nucleus, peroxisome	catalytic activity, hydrolase activity, metal ion binding, nicotinamidase activity		
YGL038C	OCH1	Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins [Source:SGD;Acc:S000003006]	protein N-linked glycosylation	Golgi apparatus, Golgi cis cisterna, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	alpha-1,6-mannosyltransferase activity, glycolipid 6-alpha-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YGL039W	YGL039W	Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols [Source:SGD;Acc:S000003007]	cellular aromatic compound metabolic process, cellular ketone metabolic process, cellular metabolic process, metabolic process, oxidation-reduction process	cytoplasm	binding, carbonyl reductase (NADPH) activity, catalytic activity, coenzyme binding, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors		
YGL040C	HEM2	Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000003008]	heme biosynthetic process, metabolic process, porphyrin biosynthetic process, tetrapyrrole biosynthetic process	cytoplasm, nucleus	catalytic activity, lyase activity, metal ion binding, porphobilinogen synthase activity		
YGL041C	YGL041C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003009]					
YGL041C-B	YGL041C-B	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028548]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YGL041W-A	YGL041W-A	Putative protein of unknown function, conserved in fungi; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028826]	biological_process	cellular_component	molecular_function		
YGL042C	YGL042C	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1 [Source:SGD;Acc:S000003010]					
YGL043W	DST1	General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites [Source:SGD;Acc:S000003011]	regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, transcription elongation from RNA polymerase II promoter, transcription elongation, DNA-dependent, transcription initiation from RNA polymerase II promoter	nucleoplasm, nucleus	DNA binding, metal ion binding, nucleic acid binding, translation elongation factor activity, zinc ion binding		
YGL044C	RNA15	Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p [Source:SGD;Acc:S000003012]	mRNA cleavage, mRNA polyadenylation, mRNA processing	mRNA cleavage factor complex, nucleus	RNA binding, mRNA binding, nucleic acid binding, nucleotide binding, protein heterodimerization activity		
YGL045W	RIM8	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family [Source:SGD;Acc:S000003013]	invasive growth in response to glucose limitation, meiosis, protein processing, ubiquitin-dependent endocytosis	internal side of plasma membrane	molecular_function		
YGL047W	ALG13	Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases [Source:SGD;Acc:S000003015]	carbohydrate metabolic process, dolichol-linked oligosaccharide biosynthetic process, lipid glycosylation	UDP-N-acetylglucosamine transferase complex, cytoplasm, cytosol, endoplasmic reticulum, extrinsic to endoplasmic reticulum membrane, membrane fraction, nucleus	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity, carbohydrate binding, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups		
YGL048C	RPT6	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle [Source:SGD;Acc:S000003016]	chromatin remodeling, positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, positive regulation of transcription elongation from RNA polymerase II promoter, proteasome regulatory particle assembly, protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus, proteasome complex, proteasome regulatory particle, base subcomplex, proteasome storage granule	ATP binding, ATPase activity, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding		
YGL049C	TIF4632	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p [Source:SGD;Acc:S000003017]	RNA metabolic process, regulation of translation, stress granule assembly, translation, translational initiation	cytoplasm, eukaryotic translation initiation factor 4F complex, ribosome, stress granule	RNA binding, binding, protein binding, translation initiation factor activity		
YGL050W	TYW3	tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions [Source:SGD;Acc:S000003018]	tRNA methylation, tRNA processing, wybutosine biosynthetic process	cellular_component	methyltransferase activity, tRNA methyltransferase activity, transferase activity		
YGL051W	MST27	Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles [Source:SGD;Acc:S000003019]	protein transport, transport, vesicle organization, vesicle-mediated transport	COPI coated vesicle membrane, ER to Golgi transport vesicle membrane, Golgi apparatus, cytoplasmic vesicle, endoplasmic reticulum, integral to membrane, membrane, plasma membrane	molecular_function		
YGL052W	YGL052W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MST27 [Source:SGD;Acc:S000003020]					
YGL053W	PRM8	Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family [Source:SGD;Acc:S000003021]	biological_process, transport, vesicle-mediated transport	endoplasmic reticulum, integral to membrane, membrane, plasma membrane	molecular_function		
YGL054C	ERV14	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon [Source:SGD;Acc:S000003022]	ER to Golgi vesicle-mediated transport, ascospore formation, axial cellular bud site selection, intracellular signal transduction	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YGL055W	OLE1	Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria [Source:SGD;Acc:S000003023]	electron transport chain, fatty acid biosynthetic process, lipid biosynthetic process, lipid metabolic process, oxidation-reduction process, transport, unsaturated fatty acid biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	electron carrier activity, heme binding, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water, stearoyl-CoA 9-desaturase activity		
YGL056C	SDS23	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding [Source:SGD;Acc:S000003024]	cytokinetic cell separation	cytoplasm, nucleus	molecular_function, protein binding		
YGL057C	GEP7	Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003025]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YGL058W	RAD6	Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p [Source:SGD;Acc:S000003026]	DNA repair, chromatin modification, chromatin silencing at telomere, double-strand break repair via homologous recombination, error-free postreplication DNA repair, error-free translesion synthesis, error-prone translesion synthesis, histone monoubiquitination, meiotic DNA double-strand break formation, mitotic cell cycle G1/S transition DNA damage checkpoint, post-translational protein modification, protein monoubiquitination, protein polyubiquitination, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, regulation of dipeptide transport, regulation of protein metabolic process, response to DNA damage stimulus, sporulation resulting in formation of a cellular spore, transcription from RNA polymerase II promoter, ubiquitin-dependent protein catabolic process via the N-end rule pathway	cytoplasm, nuclear chromatin, nucleus, proteasome complex	ATP binding, acid-amino acid ligase activity, ligase activity, nucleotide binding, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YGL059W	PKP2	Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p [Source:SGD;Acc:S000003027]	carbohydrate metabolic process, carbon utilization, glucose metabolic process, negative regulation of catalytic activity, peptidyl-serine phosphorylation	mitochondrial matrix, mitochondrion	ATP binding, kinase activity, nucleotide binding, protein kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity, transferase activity		
YGL060W	YBP2	Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p [Source:SGD;Acc:S000003028]	G2/M transition of mitotic cell cycle	centromere-specific nucleosome, condensed nuclear chromosome kinetochore, cytoplasm	molecular_function		
YGL061C	DUO1	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000003029]	cell cycle, cell division, chromosome segregation, mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization	DASH complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle, spindle microtubule, spindle pole body	microtubule binding, structural constituent of cytoskeleton		
YGL062W	PYC1	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis [Source:SGD;Acc:S000003030]	NADPH regeneration, gluconeogenesis, metabolic process	cytoplasm, cytosol	ATP binding, biotin binding, biotin carboxylase activity, catalytic activity, ligase activity, metal ion binding, nucleotide binding, pyruvate carboxylase activity		
YGL063C-A	YGL063C-A	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028633]					
YGL063W	PUS2	Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification [Source:SGD;Acc:S000003031]	RNA modification, pseudouridine synthesis, tRNA processing, tRNA pseudouridine synthesis	mitochondrion, nucleus	RNA binding, isomerase activity, pseudouridine synthase activity		
YGL064C	MRH4	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function [Source:SGD;Acc:S000003032]	ribosome biogenesis	mitochondrion	ATP binding, ATP-dependent helicase activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YGL065C	ALG2	Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol [Source:SGD;Acc:S000003033]	biosynthetic process, oligosaccharide-lipid intermediate biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	glycolipid 3-alpha-mannosyltransferase activity, glycolipid 6-alpha-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YGL066W	SGF73	SAGA complex subunit with a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases [Source:SGD;Acc:S000003034]	chromatin modification, histone acetylation, histone deubiquitination, mRNA export from nucleus, positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, protein complex assembly	DUBm complex, SAGA complex, SLIK (SAGA-like) complex, nucleus	enzyme activator activity, histone acetyltransferase activity, structural molecule activity		
YGL067W	NPY1	NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes [Source:SGD;Acc:S000003035]	NADH metabolic process	cytoplasm, peroxisome	NAD+ diphosphatase activity, hydrolase activity, metal ion binding		
YGL068W	MNP1	Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth [Source:SGD;Acc:S000003036]	aerobic respiration, translation	intracellular, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YGL069C	YGL069C	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance [Source:SGD;Acc:S000003037]					
YGL070C	RPB9	RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription [Source:SGD;Acc:S000003038]	DNA repair, response to DNA damage stimulus, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, transcription-coupled nucleotide-excision repair	DNA-directed RNA polymerase II, core complex, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding, molecular_function, nucleic acid binding, zinc ion binding		
YGL071W	AFT1	Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability [Source:SGD;Acc:S000003039]	high-affinity iron ion transport, positive regulation of transcription from RNA polymerase II promoter	cytoplasm, nucleus	metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YGL072C	YGL072C	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 [Source:SGD;Acc:S000003040]					
YGL073W	HSF1	Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated [Source:SGD;Acc:S000003041]	negative regulation of TOR signaling cascade, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to heat, response to stress, spindle pole body duplication	mitochondrion, nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YGL074C	YGL074C	Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor [Source:SGD;Acc:S000003042]					
YGL075C	MPS2	Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000003043]	mitotic anaphase, spindle pole body duplication in nuclear envelope	integral to membrane, membrane, nuclear envelope, spindle pole body	structural constituent of cytoskeleton		
YGL076C	RPL7A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2) [Source:SGD;Acc:S000003044]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, large ribosomal subunit, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YGL077C	HNM1	Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol [Source:SGD;Acc:S000003045]	amino acid transport, choline transport, ethanolamine transport, glycine betaine transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	amino acid transmembrane transporter activity, choline transmembrane transporter activity, ethanolamine transmembrane transporter activity, glycine betaine:hydrogen symporter activity		
YGL078C	DBP3	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis [Source:SGD;Acc:S000003046]	rRNA processing, ribosomal large subunit assembly, ribosome biogenesis	nucleolus, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, RNA-dependent ATPase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YGL079W	KXD1	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome [Source:SGD;Acc:S000003047]	biological_process	endosome	molecular_function		
YGL080W	FMP37	Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003048]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YGL081W	YGL081W	Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis [Source:SGD;Acc:S000003049]	biological_process	cellular_component	molecular_function, protein binding		
YGL082W	YGL082W	Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene [Source:SGD;Acc:S000003050]	biological_process	cytoplasm, nucleus, plasma membrane enriched fraction	molecular_function		
YGL083W	SCY1	Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase [Source:SGD;Acc:S000003051]	biological_process, protein phosphorylation	clathrin-coated vesicle	ATP binding, binding, molecular_function, protein kinase activity		
YGL084C	GUP1	Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport [Source:SGD;Acc:S000003052]	GPI anchor biosynthetic process, glycerol catabolic process, glycerol transport, transport	endoplasmic reticulum, integral to membrane, membrane, plasma membrane	O-acyltransferase activity, symporter activity		
YGL085W	LCL3	Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000003053]	biological_process	integral to membrane, membrane, mitochondrion	endonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding, molecular_function, nuclease activity, nucleic acid binding		
YGL086W	MAD1	Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p [Source:SGD;Acc:S000003054]	cell cycle, cell division, mitosis, mitotic cell cycle G2/M transition decatenation checkpoint, mitotic cell cycle spindle assembly checkpoint, nucleocytoplasmic transport	kinetochore, nuclear pore, nucleus	molecular_function		
YGL087C	MMS2	Ubiquitin-conjugating enzyme variant involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p [Source:SGD;Acc:S000003055]	free ubiquitin chain polymerization, post-translational protein modification, postreplication repair, protein polyubiquitination, regulation of protein metabolic process, response to DNA damage stimulus	cytoplasm, nucleus, ubiquitin conjugating enzyme complex	acid-amino acid ligase activity, ligase activity, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YGL088W	YGL088W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing [Source:SGD;Acc:S000003056]					
YGL089C	MF(ALPHA)2	Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 [Source:SGD;Acc:S000003057]	mating, pheromone-dependent signal transduction involved in conjugation with cellular fusion, sexual reproduction	extracellular region	mating pheromone activity, pheromone activity		
YGL090W	LIF1	Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein [Source:SGD;Acc:S000003058]	DNA recombination, DNA repair, double-strand break repair, double-strand break repair via nonhomologous end joining, response to DNA damage stimulus	DNA ligase IV complex, cytoplasm, nuclear chromatin, nucleus	DNA binding, chromatin binding		
YGL091C	NBP35	Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases [Source:SGD;Acc:S000003059]	iron-sulfur cluster assembly, tRNA wobble uridine modification	cytoplasm, nucleus, soluble fraction	4 iron, 4 sulfur cluster binding, ATP binding, ATPase activity, iron ion binding, iron-sulfur cluster binding, metal ion binding, nucleotide binding		
YGL092W	NUP145	Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p [Source:SGD;Acc:S000003060]	NLS-bearing substrate import into nucleus, chromosome localization, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein import into nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, tRNA splicing, via endonucleolytic cleavage and ligation, transmembrane transport, transport	Nup107-160 complex, membrane, nuclear membrane, nuclear pore, nucleus	RNA binding, hydrolase activity, structural molecule activity		
YGL093W	SPC105	Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components [Source:SGD;Acc:S000003061]	microtubule nucleation, mitotic cell cycle spindle assembly checkpoint, protein localization to kinetochore, sister chromatid biorientation	chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, membrane, mitochondrion, nuclear membrane, nucleus, spindle pole body	microtubule binding, structural constituent of cytoskeleton		
YGL094C	PAN2	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes [Source:SGD;Acc:S000003062]	mRNA 3'-end processing, mRNA processing, postreplication repair, ubiquitin-dependent protein catabolic process	PAN complex, cytoplasm, intracellular	exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, poly(A)-specific ribonuclease activity, protein binding, ubiquitin thiolesterase activity		
YGL095C	VPS45	Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment [Source:SGD;Acc:S000003063]	CVT pathway, Golgi to endosome transport, Golgi to vacuole transport, Golgi vesicle fusion to target membrane, positive regulation of SNARE complex assembly, protein targeting to vacuole, protein transport, transport, vacuolar acidification, vacuole inheritance, vacuole organization, vesicle docking involved in exocytosis, vesicle-mediated transport	Golgi membrane, SNARE complex, cytoplasm, cytosol, extrinsic to membrane, membrane, vacuolar membrane, vacuole	SNARE binding, unfolded protein binding		
YGL096W	TOS8	Homeodomain-containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; similar to Cup9p transcription factor [Source:SGD;Acc:S000003064]	biological_process, regulation of transcription, DNA-dependent	nuclear chromatin, nucleus	DNA binding, chromatin binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YGL097W	SRM1	Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000003065]	cell cycle, cell division, mitosis, rRNA export from nucleus, response to pheromone, ribosomal subunit export from nucleus	nuclear chromatin, nucleus	guanyl-nucleotide exchange factor activity, signal transducer activity		
YGL098W	USE1	Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p [Source:SGD;Acc:S000003066]	protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle fusion with endoplasmic reticulum, vesicle-mediated transport	SNARE complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to cytosolic side of endoplasmic reticulum membrane, integral to membrane, membrane	SNAP receptor activity		
YGL099W	LSG1	Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm [Source:SGD;Acc:S000003067]	ascospore formation, conjugation with cellular fusion, protein transport, ribosomal large subunit assembly, ribosomal subunit export from nucleus, transport	cytoplasm, intracellular, mating projection tip	GTP binding, GTPase activity, hydrolase activity, nucleotide binding		
YGL100W	SEH1	Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p [Source:SGD;Acc:S000003068]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	Nup107-160 complex, membrane, nuclear pore, nucleus, plasma membrane	protein binding, structural molecule activity		
YGL101W	YGL101W	Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p [Source:SGD;Acc:S000003069]	biological_process	cytoplasm, nucleus	catalytic activity, molecular_function		
YGL102C	YGL102C	Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein [Source:SGD;Acc:S000003070]					
YGL103W	RPL28	Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance [Source:SGD;Acc:S000003071]	response to antibiotic, response to cycloheximide, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, nucleus, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YGL104C	VPS73	Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family [Source:SGD;Acc:S000003072]	protein targeting to vacuole, protein transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial membrane, mitochondrion	substrate-specific transmembrane transporter activity, transporter activity		
YGL105W	ARC1	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids [Source:SGD;Acc:S000003073]	positive regulation of ligase activity, tRNA aminoacylation for protein translation	cytoplasm, methionyl glutamyl tRNA synthetase complex	DNA binding, RNA binding, enzyme activator activity, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, tRNA binding		
YGL106W	MLC1	Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition [Source:SGD;Acc:S000003074]	cell cycle, cell division, cytokinesis, cytokinesis, actomyosin contractile ring assembly, protein localization, vesicle targeting	cellular bud neck, cellular bud tip, myosin complex, vesicle	calcium ion binding, motor activity, myosin II heavy chain binding, myosin V binding		
YGL107C	RMD9	Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes [Source:SGD;Acc:S000003075]	aerobic respiration, regulation of mRNA stability, sporulation resulting in formation of a cellular spore, translational initiation	extrinsic to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YGL108C	YGL108C	Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000003076]	biological_process	cellular_component	molecular_function		
YGL109W	YGL109W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C [Source:SGD;Acc:S000003077]					
YGL110C	CUE3	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination [Source:SGD;Acc:S000003078]	biological_process	cytoplasm	protein binding, ubiquitin binding		
YGL111W	NSA1	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis [Source:SGD;Acc:S000003079]	rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor	molecular_function, protein binding		
YGL112C	TAF6	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 [Source:SGD;Acc:S000003080]	RNA polymerase II transcriptional preinitiation complex assembly, chromatin modification, histone acetylation, regulation of sequence-specific DNA binding transcription factor activity, transcription initiation, DNA-dependent	SAGA complex, SLIK (SAGA-like) complex, nucleus, transcription factor TFIID complex	DNA binding, binding, chromatin binding, protein complex scaffold		
YGL113W	SLD3	Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p [Source:SGD;Acc:S000003081]	DNA replication, DNA unwinding involved in replication, DNA-dependent DNA replication initiation, cell cycle, double-strand break repair via break-induced replication	DNA replication preinitiation complex, nuclear chromatin, nucleus	chromatin binding		
YGL114W	YGL114W	Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters [Source:SGD;Acc:S000003082]	peptide transport, protein transport, transmembrane transport, transport	integral to membrane, membrane	oligopeptide transporter activity		
YGL115W	SNF4	Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis [Source:SGD;Acc:S000003083]	carbohydrate metabolic process, metabolic process, peroxisome organization, positive regulation of gluconeogenesis, protein phosphorylation, regulation of transcription from RNA polymerase II promoter, replicative cell aging	AMP-activated protein kinase complex, cytoplasm, nuclear envelope lumen, nucleus, plasma membrane	AMP-activated protein kinase activity, catalytic activity, protein binding, protein serine/threonine kinase activator activity		
YGL116W	CDC20	Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate [Source:SGD;Acc:S000003084]	activation of mitotic anaphase-promoting complex activity, cell cycle, cell division, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, protein catabolic process	anaphase-promoting complex, mitotic checkpoint complex, nucleus	protein binding, protein binding, bridging, ubiquitin-protein ligase activity		
YGL117W	YGL117W	Putative protein of unknown function [Source:SGD;Acc:S000003085]	biological_process	cellular_component	molecular_function		
YGL118C	YGL118C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003086]					
YGL119W	COQ8	Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis [Source:SGD;Acc:S000003087]	aerobic respiration, ubiquinone biosynthetic process	extrinsic to mitochondrial inner membrane, mitochondrial matrix, mitochondrion	molecular_function		
YGL120C	PRP43	RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome [Source:SGD;Acc:S000003088]	RNA splicing, mRNA processing, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal large subunit biogenesis, spliceosome disassembly	90S preribosome, mitochondrion, nucleus, post-mRNA release spliceosomal complex	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YGL121C	GPG1	Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing [Source:SGD;Acc:S000003089]	invasive growth in response to glucose limitation, signal transduction	cellular_component, cytoplasm	signal transducer activity		
YGL122C	NAB2	Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p [Source:SGD;Acc:S000003090]	mRNA polyadenylation, poly(A)+ mRNA export from nucleus, regulation of mRNA stability	cytoplasm, nucleus	RNA binding, metal ion binding, poly(A) RNA binding		
YGL123C-A	YGL123C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W [Source:SGD;Acc:S000028634]					
YGL123W	RPS2	Protein component of the small (40S) subunit, essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p [Source:SGD;Acc:S000003091]	positive regulation of translational fidelity, rRNA export from nucleus, rRNA processing, ribosome biogenesis, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome	RNA binding, SSU rRNA binding, structural constituent of ribosome		
YGL124C	MON1	Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate [Source:SGD;Acc:S000003092]	autophagy, protein targeting to vacuole, protein transport, transport, vesicle docking	Mon1-Ccz1 complex, cytosol, endosome, fungal-type vacuole membrane, late endosome membrane, membrane, multivesicular body membrane, vacuolar membrane, vacuole	molecular_function		
YGL125W	MET13	Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway [Source:SGD;Acc:S000003093]	methionine biosynthetic process, methionine metabolic process, oxidation-reduction process	mitochondrion	methylenetetrahydrofolate reductase (NADPH) activity, oxidoreductase activity		
YGL126W	SCS3	Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol [Source:SGD;Acc:S000003094]	phospholipid biosynthetic process, phospholipid metabolic process	endoplasmic reticulum, integral to membrane, membrane	molecular_function		
YGL127C	SOH1	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits [Source:SGD;Acc:S000003095]	DNA repair, meiotic gene conversion, meiotic sister chromatid segregation, transcription from RNA polymerase II promoter	mediator complex, nucleus	molecular_function		
YGL128C	CWC23	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p [Source:SGD;Acc:S000003096]	RNA splicing, mRNA processing, spliceosome disassembly	U2-type spliceosomal complex, cytoplasm, nucleus, spliceosomal complex	heat shock protein binding, molecular_function		
YGL129C	RSM23	Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p [Source:SGD;Acc:S000003097]	mitochondrial translation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	ATP binding, nucleotide binding, structural constituent of ribosome		
YGL130W	CEG1	Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide [Source:SGD;Acc:S000003098]	mRNA capping, mRNA processing, positive regulation of transcription from RNA polymerase II promoter	mRNA cap methyltransferase complex, nucleus	GTP binding, mRNA guanylyltransferase activity, nucleotide binding, nucleotidyltransferase activity, transferase activity		
YGL131C	SNT2	DNA binding protein with similarity to the S. pombe Snt2 protein; computational analysis suggests a role in regulation of expression of genes encoding amine transporters [Source:SGD;Acc:S000003099]	biological_process	Snt2C complex, cytoplasm, nucleus	DNA binding, metal ion binding, protein binding, zinc ion binding		
YGL132W	YGL132W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C [Source:SGD;Acc:S000003100]					
YGL133W	ITC1	Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1 [Source:SGD;Acc:S000003101]	chromatin modification, chromatin remodeling, chromatin silencing at telomere, negative regulation of transcription from RNA polymerase II promoter by pheromones	chromatin accessibility complex, nucleus	molecular_function		
YGL134W	PCL10	Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate [Source:SGD;Acc:S000003102]	carbohydrate metabolic process, glycogen metabolic process, negative regulation of glycogen biosynthetic process, regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex, cytoplasm	cyclin-dependent protein kinase regulator activity		
YGL135W	RPL1B	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal [Source:SGD;Acc:S000003103]	RNA processing, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YGL136C	MRM2	Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ [Source:SGD;Acc:S000003104]	methylation, rRNA methylation, rRNA processing	mitochondrion	RNA methyltransferase activity, methyltransferase activity, nucleic acid binding, rRNA (uridine-2'-O-)-methyltransferase activity, transferase activity		
YGL137W	SEC27	Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP [Source:SGD;Acc:S000003105]	ER to Golgi vesicle-mediated transport, intracellular protein transport, late endosome to vacuole transport via multivesicular body sorting pathway, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	COPI coated vesicle membrane, COPI vesicle coat, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, membrane, membrane coat	protein binding, structural molecule activity, ubiquitin binding		
YGL138C	YGL138C	Putative protein of unknown function; has no significant sequence similarity to any known protein [Source:SGD;Acc:S000003106]	biological_process	cellular_component	molecular_function		
YGL139W	FLC3	Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER [Source:SGD;Acc:S000003107]	FAD transport, transmembrane transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion	FAD transmembrane transporter activity		
YGL140C	YGL140C	Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains [Source:SGD;Acc:S000003108]	biological_process, response to aluminum ion	cellular_component, integral to membrane, membrane	molecular_function		
YGL141W	HUL5	Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins; works in opposition to Ubp6p polyubiquitin-shortening activity; required for retrograde transport of misfolded proteins into cytoplasm during ERAD [Source:SGD;Acc:S000003109]	ER-associated protein catabolic process, protein modification process, protein polyubiquitination	cytoplasm, intracellular, nucleus, proteasome complex	acid-amino acid ligase activity, ligase activity, ubiquitin-ubiquitin ligase activity		
YGL142C	GPI10	Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog [Source:SGD;Acc:S000003110]	GPI anchor biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, intrinsic to endoplasmic reticulum membrane, membrane	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YGL143C	MRF1	Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability [Source:SGD;Acc:S000003111]	mitochondrial translation, mitochondrial translational termination, translation, translational termination	cytoplasm, mitochondrion	translation release factor activity, translation release factor activity, codon specific		
YGL144C	ROG1	Protein with putative serine active lipase domain [Source:SGD;Acc:S000003112]	cellular lipid metabolic process, lipid catabolic process, lipid metabolic process	cellular_component	hydrolase activity, hydrolase activity, acting on ester bonds, lipase activity		
YGL145W	TIP20	Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p [Source:SGD;Acc:S000003113]	protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	Dsl1p complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane	molecular_function		
YGL146C	RRT6	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins [Source:SGD;Acc:S000003114]	biological_process, transport	integral to membrane, membrane	molecular_function		
YGL147C	RPL9A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins [Source:SGD;Acc:S000003115]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	rRNA binding, structural constituent of ribosome		
YGL148W	ARO2	Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids [Source:SGD;Acc:S000003116]	aromatic amino acid family biosynthetic process, cellular amino acid biosynthetic process, response to stress	cytoplasm	chorismate synthase activity, flavin reductase activity, lyase activity		
YGL149W	YGL149W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. [Source:SGD;Acc:S000003117]					
YGL150C	INO80	ATPase, subunit of a complex containing actin and several actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription [Source:SGD;Acc:S000003118]	DNA repair, chromatin modification, chromatin remodeling, chromatin silencing at telomere, histone exchange, nucleosome mobilization, regulation of transcription from RNA polymerase II promoter in response to stress, response to DNA damage stimulus, transcription from RNA polymerase II promoter	Ino80 complex, nucleus	ATP binding, ATP-dependent 3'-5' DNA helicase activity, ATPase activity, DNA binding, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, nucleic acid binding, nucleotide binding		
YGL151W	NUT1	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription [Source:SGD;Acc:S000003119]	regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, mitochondrion, nucleus	molecular_function		
YGL152C	YGL152C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W [Source:SGD;Acc:S000003120]					
YGL153W	PEX14	Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p [Source:SGD;Acc:S000003121]	protein import into peroxisome matrix, docking, protein transport, transmembrane transport, transport	membrane, peroxisomal membrane, peroxisome	protein binding, bridging		
YGL154C	LYS5	Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine [Source:SGD;Acc:S000003122]	lysine biosynthetic process via aminoadipic acid, macromolecule biosynthetic process, protein-cofactor linkage	cytoplasm	holo-[acyl-carrier-protein] synthase activity, magnesium ion binding, transferase activity		
YGL155W	CDC43	Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis [Source:SGD;Acc:S000003123]	cellular calcium ion homeostasis, establishment of cell polarity, protein geranylgeranylation, small GTPase mediated signal transduction	CAAX-protein geranylgeranyltransferase complex, intracellular	CAAX-protein geranylgeranyltransferase activity, catalytic activity, metal ion binding, prenyltransferase activity, protein geranylgeranyltransferase activity, transferase activity		
YGL156W	AMS1	Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway [Source:SGD;Acc:S000003124]	carbohydrate metabolic process, cellular carbohydrate metabolic process, mannose metabolic process, metabolic process, oligosaccharide catabolic process	vacuolar membrane, vacuole	alpha-mannosidase activity, carbohydrate binding, catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, mannosidase activity, metal ion binding, zinc ion binding		
YGL157W	ARI1	NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily [Source:SGD;Acc:S000003125]	biological_process, cellular metabolic process, metabolic process, oxidation-reduction process	cytoplasm, nucleus	binding, carbonyl reductase (NADPH) activity, catalytic activity, coenzyme binding, oxidoreductase activity		
YGL158W	RCK1	Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations [Source:SGD;Acc:S000003126]	protein phosphorylation, regulation of meiosis	cellular_component	ATP binding, calmodulin binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YGL159W	YGL159W	Putative protein of unknown function; deletion mutant has no detectable phenotype [Source:SGD;Acc:S000003127]	biological_process, metabolic process	cellular_component	binding, catalytic activity, molecular_function		
YGL160W	AIM14	Protein with similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000003128]	biological_process	integral to membrane, membrane, ribosome	electron carrier activity, flavin adenine dinucleotide binding, iron ion binding, oxidoreductase activity, oxidoreductase activity, oxidizing metal ions		
YGL161C	YIP5	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport [Source:SGD;Acc:S000003129]	biological_process	Golgi apparatus, integral to membrane, membrane	Rab GTPase binding		
YGL162W	SUT1	Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression [Source:SGD;Acc:S000003130]	regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, sterol transport	cytoplasm, nucleus	sequence-specific DNA binding transcription factor activity, zinc ion binding		
YGL163C	RAD54	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family [Source:SGD;Acc:S000003131]	DNA geometric change, DNA repair, chromatin remodeling, double-strand break repair via synthesis-dependent strand annealing, heteroduplex formation, positive regulation of endodeoxyribonuclease activity, response to DNA damage stimulus, telomere maintenance via recombination	nucleus	ATP binding, DNA binding, DNA translocase activity, DNA-dependent ATPase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YGL164C	YRB30	RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes [Source:SGD;Acc:S000003132]	biological_process, protein transport, transport	cytoplasm, nucleus	GTPase activator activity, GTPase regulator activity		
YGL165C	YGL165C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W [Source:SGD;Acc:S000003133]					
YGL166W	CUP2	Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations [Source:SGD;Acc:S000003134]	regulation of transcription, DNA-dependent, response to copper ion, transcription initiation from RNA polymerase II promoter	nucleus	DNA binding, copper ion binding, ligand-regulated transcription factor activity, metal ion binding, sequence-specific DNA binding transcription factor activity		
YGL167C	PMR1	High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease [Source:SGD;Acc:S000003135]	ATP biosynthetic process, calcium ion transport, cation transport, exocytosis, ion transport, manganese ion transport, metabolic process, transport	Golgi apparatus, Golgi membrane, integral to membrane, membrane	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, calcium ion binding, calcium-transporting ATPase activity, catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, manganese-transporting ATPase activity, nucleotide binding		
YGL168W	HUR1	Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene [Source:SGD;Acc:S000003136]	DNA replication	cellular_component, integral to membrane, membrane	molecular_function		
YGL169W	SUA5	Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family [Source:SGD;Acc:S000003137]	regulation of translational fidelity, telomere maintenance, threonylcarbamoyladenosine metabolic process	cytoplasm	single-stranded telomeric DNA binding		
YGL170C	SPO74	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation [Source:SGD;Acc:S000003138]	ascospore formation, sporulation resulting in formation of a cellular spore	cytoplasm, cytoskeleton, nucleus, spindle pole body	structural molecule activity		
YGL171W	ROK1	ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis [Source:SGD;Acc:S000003139]	rRNA processing, ribosome biogenesis, snoRNA localization	90S preribosome, nucleolus, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, RNA-dependent ATPase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YGL172W	NUP49	Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes [Source:SGD;Acc:S000003140]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein import into nucleus, protein transport, rRNA export from nucleus, ribosomal large subunit export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, tRNA splicing, via endonucleolytic cleavage and ligation, transmembrane transport, transport	Nic96 complex, membrane, nuclear envelope, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YGL173C	KEM1	Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance [Source:SGD;Acc:S000003141]	filamentous growth, karyogamy, karyogamy involved in conjugation with cellular fusion, nonfunctional rRNA decay, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, rRNA processing, traversing start control point of mitotic cell cycle	cytoplasm, cytoplasmic mRNA processing body, intracellular, microtubule, perinuclear region of cytoplasm	5'-3' exonuclease activity, 5'-3' exoribonuclease activity, RNA binding, deoxyribonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding		
YGL174W	BUD13	Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern [Source:SGD;Acc:S000003142]	RNA splicing, cellular bud site selection, mRNA export from nucleus, mRNA processing, nuclear mRNA splicing, via spliceosome	RES complex, cytoplasm, nucleus, spliceosomal complex	molecular_function		
YGL175C	SAE2	Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents [Source:SGD;Acc:S000003143]	DNA catabolic process, endonucleolytic, DNA double-strand break processing, DNA repair, gene conversion at mating-type locus, DNA double-strand break processing, meiosis, meiotic DNA double-strand break processing, response to DNA damage stimulus	cytoplasm, nucleus	DNA binding, double-stranded DNA binding, endonuclease activity, hydrolase activity, nuclease activity, single-stranded DNA specific endodeoxyribonuclease activity		
YGL176C	YGL176C	Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype [Source:SGD;Acc:S000003144]	biological_process	cellular_component	molecular_function		
YGL177W	YGL177W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003145]					
YGL178W	MPT5	Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest [Source:SGD;Acc:S000003146]	fungal-type cell wall organization, loss of chromatin silencing involved in replicative cell aging, negative regulation of translation, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, protein localization, re-entry into mitotic cell cycle after pheromone arrest, replicative cell aging	cytoplasm	RNA binding, binding, mRNA binding		
YGL179C	TOS3	Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome [Source:SGD;Acc:S000003147]	glucose metabolic process, protein phosphorylation, response to stress	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YGL180W	ATG1	Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p [Source:SGD;Acc:S000003148]	CVT pathway, autophagic vacuole assembly, autophagy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein phosphorylation, protein transport, transport	Atg1p signaling complex, cytoplasm, cytosol, membrane, pre-autophagosomal structure, pre-autophagosomal structure membrane	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YGL181W	GTS1	Arf3p GTPase Activating Protein (GAP) that localizes to endocytic patches; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms; localizes to nucleus and induces flocculation when overexpressed [Source:SGD;Acc:S000003149]	ascospore formation, cell morphogenesis, chronological cell aging, endocytosis, negative regulation of phosphatidylinositol biosynthetic process, regulation of ARF GTPase activity, regulation of cell cycle, ultradian rhythm	actin cortical patch, cytoplasm, nucleus	ARF GTPase activator activity, metal ion binding, protein binding, zinc ion binding		
YGL182C	YGL182C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MND1/YGL183C [Source:SGD;Acc:S000003150]					
YGL183C	MND1	Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks [Source:SGD;Acc:S000003151]	DNA recombination, meiosis, reciprocal meiotic recombination	condensed nuclear chromosome, nucleus	DNA binding, double-stranded DNA binding, protein binding		
YGL184C	STR3	Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p [Source:SGD;Acc:S000003152]	'de novo' L-methionine biosynthetic process, cellular amino acid biosynthetic process, cellular amino acid metabolic process, methionine biosynthetic process, transsulfuration	cytoplasm, nucleus, peroxisome	catalytic activity, cystathionine beta-lyase activity, lyase activity, pyridoxal phosphate binding		
YGL185C	YGL185C	Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003153]	metabolic process, oxidation-reduction process	cytoplasm	binding, catalytic activity, cofactor binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YGL186C	TPN1	Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p [Source:SGD;Acc:S000003154]	nucleobase, nucleoside, nucleotide and nucleic acid transport, transmembrane transport, transport, vitamin transport	integral to membrane, membrane, plasma membrane	nucleobase transmembrane transporter activity, vitamin transporter activity		
YGL187C	COX4	Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation [Source:SGD;Acc:S000003155]	aerobic respiration, mitochondrial electron transport, cytochrome c to oxygen	membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion	cytochrome-c oxidase activity, metal ion binding, zinc ion binding		
YGL188C	YGL188C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003156]					
YGL188C-A	YGL188C-A	Putative protein of unknown function [Source:SGD;Acc:S000028635]	biological_process	cellular_component	molecular_function		
YGL189C	RPS26A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein [Source:SGD;Acc:S000003157]	rRNA export from nucleus, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YGL190C	CDC55	Non-essential regulatory subunit B of protein phosphatase 2A (PP2A), which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at bud neck and bud tip [Source:SGD;Acc:S000003158]	actin filament organization, budding cell bud growth, cell cycle, cell shape checkpoint, mitotic cell cycle spindle assembly checkpoint, negative regulation of exit from mitosis, protein dephosphorylation, pseudohyphal growth, regulation of translation, signal transduction	cellular bud neck, cellular bud tip, nucleus, protein phosphatase type 2A complex	protein binding, protein phosphatase type 2A regulator activity, protein serine/threonine phosphatase activity		
YGL191W	COX13	Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP [Source:SGD;Acc:S000003159]	aerobic respiration	membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion	cytochrome-c oxidase activity, enzyme regulator activity		
YGL192W	IME4	Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids [Source:SGD;Acc:S000003160]	mRNA methylation, meiosis, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, sporulation resulting in formation of a cellular spore	cellular_component, nucleus	RNA binding, mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity, mRNA (N6-adenosine)-methyltransferase activity, methyltransferase activity, transferase activity		
YGL193C	YGL193C	Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold [Source:SGD;Acc:S000003161]	biological_process	cellular_component	molecular_function		
YGL194C	HOS2	Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity [Source:SGD;Acc:S000003162]	chromatin modification, chromatin organization, histone deacetylation, negative regulation of meiosis, positive regulation of stress-activated MAPK cascade, regulation of transcription, DNA-dependent	Rpd3L-Expanded complex, Set3 complex, nucleus	NAD-dependent histone deacetylase activity, NAD-independent histone deacetylase activity, histone deacetylase activity, hydrolase activity		
YGL194C-A	YGL194C-A	Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species [Source:SGD;Acc:S000087160]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YGL195W	GCN1	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA [Source:SGD;Acc:S000003163]	regulation of translation, regulation of translational elongation	cytosol, cytosolic ribosome, mitochondrion	binding, molecular_function		
YGL196W	DSD1	D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate [Source:SGD;Acc:S000003164]	D-serine metabolic process	cellular_component	D-serine ammonia-lyase activity, lyase activity		
YGL197W	MDS3	Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain [Source:SGD;Acc:S000003165]	TOR signaling cascade, meiosis, negative regulation of sporulation resulting in formation of a cellular spore, sporulation resulting in formation of a cellular spore	cytoplasm, mitochondrion	molecular_function		
YGL198W	YIP4	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport [Source:SGD;Acc:S000003166]	biological_process	Golgi apparatus, Golgi membrane, integral to membrane, membrane	Rab GTPase binding		
YGL199C	YGL199C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W [Source:SGD;Acc:S000003167]					
YGL200C	EMP24	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport [Source:SGD;Acc:S000003168]	ER to Golgi vesicle-mediated transport, protein retention in ER lumen, protein transport, transport, vesicle organization, vesicle-mediated transport	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YGL201C	MCM6	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex [Source:SGD;Acc:S000003169]	DNA replication, DNA strand elongation involved in DNA replication, DNA unwinding involved in replication, DNA-dependent DNA replication initiation, S phase of mitotic cell cycle, cell cycle, double-strand break repair via break-induced replication, pre-replicative complex assembly	DNA replication preinitiation complex, MCM complex, cytoplasm, nucleus, pre-replicative complex, replication fork protection complex	ATP binding, ATP-dependent 3'-5' DNA helicase activity, DNA binding, DNA replication origin binding, four-way junction helicase activity, nucleotide binding, single-stranded DNA-dependent ATPase activity		
YGL202W	ARO8	Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis [Source:SGD;Acc:S000003170]	aromatic amino acid family metabolic process, biosynthetic process	cytoplasm	2-aminoadipate transaminase activity, aromatic-amino-acid:2-oxoglutarate aminotransferase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity, transferase activity, transferring nitrogenous groups		
YGL203C	KEX1	Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins [Source:SGD;Acc:S000003171]	protein processing, proteolysis	integral to membrane, membrane, trans-Golgi network	carboxypeptidase activity, hydrolase activity, peptidase activity, serine-type carboxypeptidase activity		
YGL204C	YGL204C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003172]					
YGL205W	POX1	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix [Source:SGD;Acc:S000003173]	fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process, metabolic process, oxidation-reduction process	peroxisomal matrix, peroxisome	acyl-CoA dehydrogenase activity, acyl-CoA oxidase activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors		
YGL206C	CHC1	Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function [Source:SGD;Acc:S000003174]	endocytosis, intracellular protein transport, vesicle-mediated transport	clathrin coat of coated pit, clathrin coat of trans-Golgi network vesicle, clathrin vesicle coat, coated pit, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane	binding, structural molecule activity		
YGL207W	SPT16	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases [Source:SGD;Acc:S000003175]	DNA repair, DNA replication, DNA replication-independent nucleosome organization, DNA-dependent DNA replication, cellular process, nucleosome assembly, positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, positive regulation of transcription initiation from RNA polymerase II promoter, regulation of transcription by chromatin organization, response to DNA damage stimulus, transcription elongation from RNA polymerase II promoter	FACT complex, alpha DNA polymerase:primase complex, chromosome, nuclear chromatin, nucleus, replication fork protection complex, transcription elongation factor complex	chromatin binding, histone binding, nucleosome binding		
YGL208W	SIP2	One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane [Source:SGD;Acc:S000003176]	cellular response to glucose starvation, invasive growth in response to glucose limitation, protein phosphorylation, regulation of protein complex assembly, replicative cell aging, signal transduction	AMP-activated protein kinase complex, cytoplasm, membrane, plasma membrane	AMP-activated protein kinase activity		
YGL209W	MIG2	Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter [Source:SGD;Acc:S000003177]	carbohydrate metabolic process, negative regulation of transcription from RNA polymerase II promoter by glucose	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YGL210W	YPT32	Rab family GTPase, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi [Source:SGD;Acc:S000003178]	early endosome to Golgi transport, exocytosis, protein transport, small GTPase mediated signal transduction, transport, vesicle-mediated transport	Golgi apparatus, Golgi membrane, endosome, membrane, mitochondrial outer membrane	GTP binding, GTPase activity, nucleotide binding		
YGL211W	NCS6	Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae [Source:SGD;Acc:S000003179]	protein urmylation, tRNA processing, tRNA wobble position uridine thiolation, tRNA wobble uridine modification	cytoplasm, mitochondrion	ATP binding, RNA binding, tRNA binding, transferase activity		
YGL212W	VAM7	Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking [Source:SGD;Acc:S000003180]	Golgi to vacuole transport, cell communication, piecemeal microautophagy of nucleus, vacuole fusion, non-autophagic, vesicle fusion	fungal-type vacuole membrane, vacuole	SNAP receptor activity, phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding		
YGL213C	SKI8	Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype [Source:SGD;Acc:S000003181]	meiosis, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, protein complex assembly, protein-DNA complex assembly, reciprocal meiotic recombination, response to virus	Ski complex, chromosome, cytoplasm, nuclear chromosome, nucleus	molecular_function, protein binding		
YGL214W	YGL214W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C [Source:SGD;Acc:S000003182]					
YGL215W	CLG1	Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 [Source:SGD;Acc:S000003183]	positive regulation of macroautophagy	cyclin-dependent protein kinase holoenzyme complex	cyclin-dependent protein kinase regulator activity		
YGL216W	KIP3	Kinesin-related motor protein involved in mitotic spindle positioning [Source:SGD;Acc:S000003184]	establishment of mitotic spindle orientation, microtubule-based movement, mitotic spindle disassembly, mitotic spindle organization in nucleus, nuclear migration along microtubule, plus-end specific microtubule depolymerization	cytoplasm, cytoplasmic microtubule, cytoskeleton, kinesin complex, microtubule, nuclear microtubule	ATP binding, microtubule motor activity, motor activity, nucleotide binding, plus-end-directed microtubule motor activity, tubulin-dependent ATPase activity		
YGL217C	YGL217C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W [Source:SGD;Acc:S000003185]					
YGL218W	YGL218W	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance [Source:SGD;Acc:S000003186]					
YGL219C	MDM34	Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth [Source:SGD;Acc:S000003187]	mitochondrion organization, phospholipid transport	cytoplasm, integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YGL220W	FRA2	Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel [Source:SGD;Acc:S000003188]	negative regulation of transcription from RNA polymerase II promoter in response to iron	cytoplasm, cytosol, nucleus	molecular_function		
YGL221C	NIF3	Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003189]	biological_process	cytoplasm, mitochondrion	molecular_function		
YGL222C	EDC1	RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress [Source:SGD;Acc:S000003190]	deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA processing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of translation in response to stress	cytoplasm, nucleus	RNA binding, mRNA binding		
YGL223C	COG1	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000003191]	CVT pathway, intra-Golgi vesicle-mediated transport, protein transport, retrograde transport, vesicle recycling within Golgi, transport	Golgi apparatus, Golgi membrane, Golgi transport complex, membrane	molecular_function		
YGL224C	SDT1	Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives [Source:SGD;Acc:S000003192]	metabolic process, pyrimidine base metabolic process	cellular_component	catalytic activity, hydrolase activity, nucleotidase activity		
YGL225W	VRG4	Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi [Source:SGD;Acc:S000003193]	carbohydrate transport, lipid glycosylation, nucleotide-sugar transport, protein N-linked glycosylation, transmembrane transport, transport	Golgi apparatus, Golgi membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion	nucleotide-sugar transmembrane transporter activity		
YGL226C-A	OST5	Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins [Source:SGD;Acc:S000003194]	protein N-linked glycosylation	integral to membrane, membrane, oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity, transferase activity		
YGL226W	MTC3	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 [Source:SGD;Acc:S000003195]	biological_process	mitochondrion	cytochrome-c oxidase activity, molecular_function		
YGL227W	VID30	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); binds FBPase; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm [Source:SGD;Acc:S000003196]	negative regulation of gluconeogenesis, proteasomal ubiquitin-dependent protein catabolic process, regulation of nitrogen utilization, vacuolar protein catabolic process	GID complex, cytoplasm, nucleus	molecular_function, protein binding		
YGL228W	SHE10	Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest [Source:SGD;Acc:S000003197]	biological_process	cellular_component	molecular_function		
YGL229C	SAP4	Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p [Source:SGD;Acc:S000003198]	G1/S transition of mitotic cell cycle, cell cycle	cytoplasm, mitochondrion	protein serine/threonine phosphatase activity		
YGL230C	YGL230C	Putative protein of unknown function; non-essential gene [Source:SGD;Acc:S000003199]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YGL231C	EMC4	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis [Source:SGD;Acc:S000003200]	protein folding in endoplasmic reticulum	ER membrane protein complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YGL232W	TAN1	Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA [Source:SGD;Acc:S000003201]	tRNA modification, tRNA processing	cytoplasm, nucleus	RNA binding, acyltransferase activity, transferase activity		
YGL233W	SEC15	Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles [Source:SGD;Acc:S000003202]	Golgi to plasma membrane transport, bipolar cellular bud site selection, cytokinesis, exocytosis, protein transport, transport, vesicle docking involved in exocytosis, vesicle fusion	cytoplasm, exocyst, mating projection tip, membrane, plasma membrane	Rab GTPase binding		
YGL234W	ADE5,7	Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities [Source:SGD;Acc:S000003203]	'de novo' IMP biosynthetic process, purine base biosynthetic process, purine base metabolic process, purine nucleotide biosynthetic process	cytoplasm	ATP binding, catalytic activity, ligase activity, metal ion binding, nucleotide binding, phosphoribosylamine-glycine ligase activity, phosphoribosylformylglycinamidine cyclo-ligase activity		
YGL235W	YGL235W	Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 [Source:SGD;Acc:S000003204]	biological_process	cellular_component	molecular_function		
YGL236C	MTO1	Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants [Source:SGD;Acc:S000003205]	mitochondrial tRNA wobble uridine modification, tRNA processing, tRNA wobble uridine modification	mitochondrion	flavin adenine dinucleotide binding, molecular_function		
YGL237C	HAP2	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding [Source:SGD;Acc:S000003206]	regulation of carbohydrate metabolic process, regulation of transcription, DNA-dependent	CCAAT-binding factor complex, nucleus	DNA binding, sequence-specific DNA binding transcription factor activity		
YGL238W	CSE1	Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation [Source:SGD;Acc:S000003207]	cell cycle, cell division, cell proliferation, intracellular protein transport, mitosis, protein export from nucleus, protein transport, transport	cytoplasm, nuclear envelope, nucleus	binding, importin-alpha export receptor activity, protein transporter activity		
YGL239C	YGL239C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene CSE1 [Source:SGD;Acc:S000003208]					
YGL240W	DOC1	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis [Source:SGD;Acc:S000003209]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, cyclin catabolic process, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, regulation of mitotic metaphase/anaphase transition	anaphase-promoting complex, cytoplasm, mitochondrion, nucleus	enzyme regulator activity		
YGL241W	KAP114	Karyopherin, responsible for nuclear import of Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear [Source:SGD;Acc:S000003210]	intracellular protein transport, mRNA transport, protein import into nucleus, protein transport, transcription factor import into nucleus, transmembrane transport, transport	cytoplasm, nuclear pore, nucleus	binding, protein transporter activity		
YGL242C	YGL242C	Putative protein of unknown function; deletion mutant is viable [Source:SGD;Acc:S000003211]	biological_process	cellular_component	molecular_function, protein binding		
YGL243W	TAD1	tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala [Source:SGD;Acc:S000003212]	RNA processing, tRNA modification, tRNA processing	nucleus	RNA binding, adenosine deaminase activity, hydrolase activity, metal ion binding, tRNA-specific adenosine-37 deaminase activity		
YGL244W	RTF1	Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance [Source:SGD;Acc:S000003213]	histone methylation, histone modification, histone monoubiquitination, transcription elongation from RNA polymerase II promoter, transcription from RNA polymerase II promoter, transcription initiation, DNA-dependent	Cdc73/Paf1 complex, nucleoplasm, nucleus, transcription elongation factor complex	DNA binding		
YGL245W	GUS1	Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm [Source:SGD;Acc:S000003214]	glutamyl-tRNA aminoacylation, tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, methionyl glutamyl tRNA synthetase complex, mitochondrion	ATP binding, RNA binding, aminoacyl-tRNA ligase activity, glutamate-tRNA ligase activity, ligase activity, ligase activity, forming aminoacyl-tRNA and related compounds, nucleotide binding		
YGL246C	RAI1	Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z [Source:SGD;Acc:S000003215]	deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA processing, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, termination of RNA polymerase II transcription, poly(A)-coupled, transcription termination, DNA-dependent	nucleus	enzyme regulator activity, m7G(5')pppN diphosphatase activity		
YGL247W	BRR6	Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism [Source:SGD;Acc:S000003216]	cellular lipid metabolic process, mRNA export from nucleus, mRNA transport, nuclear envelope organization, protein export from nucleus, protein transport, transport	integral to membrane, membrane, nuclear envelope, nuclear membrane, nucleus	molecular_function		
YGL248W	PDE1	Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation [Source:SGD;Acc:S000003217]	cAMP catabolic process, cAMP-mediated signaling	cellular_component	3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, hydrolase activity		
YGL249W	ZIP2	Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis [Source:SGD;Acc:S000003218]	cell cycle, chromosome segregation, meiosis, reciprocal meiotic recombination, synapsis, synaptonemal complex assembly	chromosome, nucleus, synaptonemal complex	DNA binding, molecular_function, nucleotide binding		
YGL250W	RMR1	Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus [Source:SGD;Acc:S000003219]	meiotic gene conversion, reciprocal meiotic recombination	cytoplasm, nucleus	molecular_function		
YGL251C	HFM1	Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity [Source:SGD;Acc:S000003220]	DNA unwinding involved in replication, meiosis, reciprocal meiotic recombination, synapsis	nucleus	ATP binding, ATP-dependent helicase activity, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, metal ion binding, nucleic acid binding, nucleoside-triphosphatase activity, nucleotide binding		
YGL252C	RTG2	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p [Source:SGD;Acc:S000003221]	extrachromosomal rDNA circle accumulation involved in replicative cell aging, intracellular signal transduction, mitochondria-nucleus signaling pathway	SLIK (SAGA-like) complex, cytoplasm			
YGL253W	HXK2	Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene [Source:SGD;Acc:S000003222]	carbohydrate metabolic process, fructose import, fructose metabolic process, glucose import, glucose metabolic process, glycolysis, mannose metabolic process, regulation of cell size, regulation of transcription by glucose, replicative cell aging	cytosol, mitochondrion, nucleus	ATP binding, catalytic activity, hexokinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YGL254W	FZF1	Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers [Source:SGD;Acc:S000003223]	positive regulation of transcription from RNA polymerase II promoter, sulfite transport	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YGL255W	ZRT1	High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor [Source:SGD;Acc:S000003224]	high-affinity zinc ion transport, ion transport, metal ion transport, transmembrane transport, transport, zinc ion transport	integral to membrane, integral to plasma membrane, membrane	high affinity zinc uptake transmembrane transporter activity, metal ion transmembrane transporter activity, zinc ion transmembrane transporter activity		
YGL256W	ADH4	Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency [Source:SGD;Acc:S000003225]	amino acid catabolic process to alcohol via Ehrlich pathway, fermentation, oxidation-reduction process	mitochondrion	alcohol dehydrogenase (NAD) activity, metal ion binding, oxidoreductase activity		
YGL257C	MNT2	Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans [Source:SGD;Acc:S000003226]	protein O-linked glycosylation	Golgi apparatus, Golgi membrane, cellular_component, integral to membrane, membrane	alpha-1,3-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YGL258W	VEL1	Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants [Source:SGD;Acc:S000003227]	biological_process	cytoplasm, cytosol, soluble fraction	molecular_function		
YGL258W-A	YGL258W-A	Putative protein of unknown function [Source:SGD;Acc:S000007607]	biological_process, proteolysis	cellular_component	aspartic-type endopeptidase activity, molecular_function		
YGL259W	YPS5	Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p [Source:SGD;Acc:S000003228]	biological_process, proteolysis	cellular_component	aspartic-type endopeptidase activity		
YGL260W	YGL260W	Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium [Source:SGD;Acc:S000003229]	biological_process	cellular_component	molecular_function		
YGL261C	PAU11	Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 [Source:SGD;Acc:S000003230]	biological_process, response to stress	cellular_component	molecular_function		
YGL262W	YGL262W	Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene [Source:SGD;Acc:S000003231]	biological_process	cellular_component	molecular_function		
YGL263W	COS12	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000003232]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YGR001C	YGR001C	Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae [Source:SGD;Acc:S000003233]	biological_process, methylation	cytoplasm	methyltransferase activity, nucleic acid binding, transferase activity		
YGR002C	SWC4	Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex [Source:SGD;Acc:S000003234]	DNA repair, chromatin modification, chromatin remodeling, chromosome organization, establishment of mitotic sister chromatid cohesion, histone acetylation, histone exchange, response to DNA damage stimulus	NuA4 histone acetyltransferase complex, Swr1 complex, histone acetyltransferase complex, nucleus	DNA binding, protein binding		
YGR003W	CUL3	Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21 [Source:SGD;Acc:S000003235]	protein ubiquitination involved in ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process	Cul3-RING ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, cytoplasm, nucleus	protein binding, ubiquitin protein ligase binding, ubiquitin-protein ligase activity		
YGR004W	PEX31	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p [Source:SGD;Acc:S000003236]	peroxisome organization	integral to membrane, integral to peroxisomal membrane, membrane, peroxisomal membrane, peroxisome	molecular_function		
YGR005C	TFG2	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30 [Source:SGD;Acc:S000003237]	transcription initiation from RNA polymerase II promoter	nucleus, transcription factor TFIIF complex	ATP binding, DNA binding, catalytic activity, helicase activity, hydrolase activity, nucleotide binding		
YGR006W	PRP18	Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p [Source:SGD;Acc:S000003238]	RNA splicing, generation of catalytic spliceosome for second transesterification step, mRNA processing, nuclear mRNA splicing, via spliceosome, nuclear retention of unspliced pre-mRNA at the site of transcription	U4/U6 x U5 tri-snRNP complex, U5 snRNP, nucleus, spliceosomal complex	second spliceosomal transesterification activity		
YGR007W	ECT1	Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases [Source:SGD;Acc:S000003239]	biosynthetic process, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process	cytoplasm, nucleus	catalytic activity, ethanolamine-phosphate cytidylyltransferase activity, nucleotidyltransferase activity, transferase activity		
YGR008C	STF2	Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein [Source:SGD;Acc:S000003240]	regulation of ATPase activity	mitochondrial proton-transporting ATP synthase complex, mitochondrion	molecular_function		
YGR009C	SEC9	t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog [Source:SGD;Acc:S000003241]	Golgi to plasma membrane transport, protein transport, transport, vesicle fusion	SNARE complex, extrinsic to plasma membrane	SNAP receptor activity, protein binding		
YGR010W	NMA2	Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(+) [Source:SGD;Acc:S000003242]	NAD biosynthetic process, NAD metabolic process, biosynthetic process, pyridine nucleotide biosynthetic process	nucleus	ATP binding, nicotinamide-nucleotide adenylyltransferase activity, nicotinate-nucleotide adenylyltransferase activity, nucleotide binding, nucleotidyltransferase activity, transferase activity		
YGR011W	YGR011W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003243]					
YGR012W	YGR012W	Putative cysteine synthase, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000003244]	cellular amino acid biosynthetic process, cysteine biosynthetic process, cysteine biosynthetic process from serine, metabolic process	mitochondrial outer membrane, mitochondrion	catalytic activity, cysteine synthase activity, pyridoxal phosphate binding, transferase activity		
YGR013W	SNU71	Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart [Source:SGD;Acc:S000003245]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, cytoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex	RNA binding		
YGR014W	MSB2	Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate [Source:SGD;Acc:S000003246]	establishment of cell polarity, hyperosmotic response, osmosensory signaling pathway via Sho1 osmosensor, response to osmotic stress, signal transduction involved in filamentous growth	integral to plasma membrane, site of polarized growth	osmosensor activity		
YGR015C	YGR015C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion [Source:SGD;Acc:S000003247]	biological_process	mitochondrion	hydrolase activity, molecular_function		
YGR016W	YGR016W	Putative protein of unknown function [Source:SGD;Acc:S000003248]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YGR017W	YGR017W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm [Source:SGD;Acc:S000003249]	biological_process	cytoplasm, nucleus	FMN binding, molecular_function		
YGR018C	YGR018C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR017W [Source:SGD;Acc:S000003250]					
YGR019W	UGA1	Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization [Source:SGD;Acc:S000003251]	gamma-aminobutyric acid catabolic process, gamma-aminobutyric acid metabolic process, nitrogen utilization	cytoplasm, intracellular	4-aminobutyrate transaminase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity		
YGR020C	VMA7	Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane [Source:SGD;Acc:S000003252]	ATP hydrolysis coupled proton transport, ATP synthesis coupled proton transport, ion transport, proton transport, transport, vacuolar acidification	fungal-type vacuole membrane, proton-transporting V-type ATPase, V1 domain, proton-transporting two-sector ATPase complex, catalytic domain, vacuolar proton-transporting V-type ATPase, V1 domain	hydrogen ion transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism		
YGR021W	YGR021W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003253]	biological_process	mitochondrion	molecular_function		
YGR022C	YGR022C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W [Source:SGD;Acc:S000003254]					
YGR023W	MTL1	Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p [Source:SGD;Acc:S000003255]	cellular response to glucose starvation, cellular response to oxidative stress, fungal-type cell wall organization, response to stress	integral to membrane, integral to plasma membrane, membrane	molecular_function		
YGR024C	THG1	tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes [Source:SGD;Acc:S000003256]	tRNA modification, tRNA processing	cytoplasm, nucleus	nucleotidyltransferase activity, tRNA guanylyltransferase activity, transferase activity		
YGR025W	YGR025W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003257]					
YGR026W	YGR026W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000003258]	biological_process	cellular_component, integral to membrane, membrane, plasma membrane	molecular_function		
YGR027C	RPS25A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein [Source:SGD;Acc:S000003259]	translation	cytoplasm, cytosolic small ribosomal subunit, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YGR027W-A	YGR027W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007405]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YGR027W-B	YGR027W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007406]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YGR028W	MSP1	Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase [Source:SGD;Acc:S000003260]	protein targeting to mitochondrion	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding		
YGR029W	ERV1	Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR) [Source:SGD;Acc:S000003261]	cellular iron ion homeostasis, cellular response to oxidative stress, oxidation-reduction process, protein import into mitochondrial intermembrane space	mitochondrial intermembrane space, mitochondrion	flavin-linked sulfhydryl oxidase activity, oxidoreductase activity, thiol oxidase activity		
YGR030C	POP6	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends [Source:SGD;Acc:S000003262]	intronic box C/D snoRNA processing, mRNA cleavage, rRNA processing, tRNA processing	nucleolar ribonuclease P complex, nucleus, ribonuclease MRP complex	hydrolase activity, nucleic acid binding, ribonuclease MRP activity, ribonuclease P activity		
YGR031C-A	NAG1	Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; null is hypersensitive to calcofluor white; overlaps the uncharacterized ORF YGR031W [Source:SGD;Acc:S000028636]	cell wall biogenesis, cellular cell wall organization	integral to membrane, membrane, plasma membrane	molecular_function		
YGR031W	YGR031W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003263]	biological_process	mitochondrion	hydrolase activity, molecular_function		
YGR032W	GSC2	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p) [Source:SGD;Acc:S000003264]	1,3-beta-D-glucan biosynthetic process, ascospore wall assembly, cellular cell wall organization, regulation of cell shape, sporulation resulting in formation of a cellular spore	1,3-beta-D-glucan synthase complex, actin cap, integral to membrane, membrane, membrane fraction, prospore membrane	1,3-beta-D-glucan synthase activity, transferase activity, transferase activity, transferring glycosyl groups		
YGR033C	TIM21	Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity [Source:SGD;Acc:S000003265]	protein import into mitochondrial matrix, protein transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial inner membrane presequence translocase complex, mitochondrion	molecular_function		
YGR034W	RPL26B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA [Source:SGD;Acc:S000003266]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, large ribosomal subunit, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YGR035C	YGR035C	Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance [Source:SGD;Acc:S000003267]	biological_process	cellular_component	molecular_function		
YGR035W-A	YGR035W-A	Putative protein of unknown function [Source:SGD;Acc:S000028827]	biological_process	cellular_component	molecular_function		
YGR036C	CAX4	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation [Source:SGD;Acc:S000003268]	lipid biosynthetic process, protein N-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	catalytic activity, dolichyldiphosphatase activity, hydrolase activity		
YGR037C	ACB1	Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion [Source:SGD;Acc:S000003269]	chronological cell aging, fatty acid metabolic process, long-chain fatty acid transport, transport	cytoplasm, extracellular region, nucleus	binding, fatty-acyl-CoA binding, lipid binding, long-chain fatty acid transporter activity		
YGR038C-A	YGR038C-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007407]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YGR038C-B	YGR038C-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007408]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YGR038W	ORM1	Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control [Source:SGD;Acc:S000003270]	negative regulation of sphingolipid biosynthetic process, response to unfolded protein	SPOTS complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YGR039W	YGR039W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722 [Source:SGD;Acc:S000003271]					
YGR040W	KSS1	Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272]	cell cycle, invasive growth in response to glucose limitation, negative regulation of sequence-specific DNA binding transcription factor activity, pheromone-dependent signal transduction involved in conjugation with cellular fusion, protein phosphorylation, signal transduction involved in filamentous growth	cytoplasm, nucleus, periplasmic space	ATP binding, MAP kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transcription factor binding, transferase activity		
YGR041W	BUD9	Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole [Source:SGD;Acc:S000003273]	cell cycle, cellular bud site selection	cellular bud neck, integral to membrane, membrane, plasma membrane	molecular_function		
YGR042W	YGR042W	Putative protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000003274]	biological_process	cytoplasm, nucleus	molecular_function		
YGR043C	NQM1	Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift [Source:SGD;Acc:S000003275]	biological_process, carbohydrate metabolic process, metabolic process, pentose-phosphate shunt	cytoplasm, nucleus	catalytic activity, sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity, transferase activity		
YGR044C	RME1	Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation [Source:SGD;Acc:S000003276]	cell cycle, cell division, meiosis, mitosis, negative regulation of transcription from RNA polymerase II promoter	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YGR045C	YGR045C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003277]					
YGR046W	TAM41	Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud [Source:SGD;Acc:S000003278]	cardiolipin biosynthetic process, protein import into mitochondrial matrix, protein transport, transmembrane transport, transport	extrinsic to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion	molecular_function		
YGR047C	TFC4	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 [Source:SGD;Acc:S000003279]	transcription initiation from RNA polymerase III promoter	nucleus, transcription factor TFIIIC complex	DNA binding, binding, protein binding		
YGR048W	UFD1	Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol [Source:SGD;Acc:S000003280]	ER-associated protein catabolic process, cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process	Cdc48p-Npl4p-Ufd1p AAA ATPase complex	polyubiquitin binding		
YGR049W	SCM4	Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis [Source:SGD;Acc:S000003281]	cell cycle	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YGR050C	YGR050C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003282]					
YGR051C	YGR051C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene [Source:SGD;Acc:S000003283]					
YGR052W	FMP48	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000003284]	biological_process, protein phosphorylation	mitochondrion	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YGR053C	YGR053C	Putative protein of unknown function [Source:SGD;Acc:S000003285]	biological_process	cellular_component	molecular_function		
YGR054W	YGR054W	Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A [Source:SGD;Acc:S000003286]	regulation of translation, translation, translational initiation	cytosolic ribosome, cytosolic small ribosomal subunit, ribosome	protein binding, translation initiation factor activity		
YGR055W	MUP1	High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake [Source:SGD;Acc:S000003287]	amino acid transport, sulfur amino acid transport, transmembrane transport, transport	integral to membrane, integral to plasma membrane, membrane	L-methionine secondary active transmembrane transporter activity, amino acid transmembrane transporter activity		
YGR056W	RSC1	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook [Source:SGD;Acc:S000003288]	ATP-dependent chromatin remodeling, chromatin modification, double-strand break repair via nonhomologous end joining, nucleosome disassembly, regulation of sporulation resulting in formation of a cellular spore, sporulation resulting in formation of a cellular spore, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	DNA binding, DNA-dependent ATPase activity, protein binding		
YGR057C	LST7	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface [Source:SGD;Acc:S000003289]	Golgi to plasma membrane transport, intracellular protein transport, protein transport, vesicle-mediated transport	vesicle coat	protein transporter activity		
YGR058W	PEF1	Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2 [Source:SGD;Acc:S000003290]	axial cellular bud site selection, bipolar cellular bud site selection	cellular bud neck, cellular bud tip, cytoplasm, nucleus, site of polarized growth	calcium ion binding, zinc ion binding		
YGR059W	SPR3	Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI [Source:SGD;Acc:S000003291]	ascospore wall assembly, cell cycle, cell morphogenesis, cell morphogenesis involved in conjugation with cellular fusion, fungal-type cell wall organization, sporulation resulting in formation of a cellular spore	ascospore wall, cellular bud neck, cellular bud neck septin ring, membrane, prospore membrane, septin complex	GTP binding, nucleotide binding, structural constituent of cytoskeleton		
YGR060W	ERG25	C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol [Source:SGD;Acc:S000003292]	ergosterol biosynthetic process, fatty acid biosynthetic process, lipid biosynthetic process, oxidation-reduction process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, plasma membrane	C-4 methylsterol oxidase activity, iron ion binding, oxidoreductase activity		
YGR061C	ADE6	Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway [Source:SGD;Acc:S000003293]	'de novo' IMP biosynthetic process, glutamine metabolic process, purine nucleotide biosynthetic process	cytoplasm	ATP binding, catalytic activity, ligase activity, nucleotide binding, phosphoribosylformylglycinamidine synthase activity		
YGR062C	COX18	Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC [Source:SGD;Acc:S000003294]	protein insertion into membrane, protein insertion into mitochondrial membrane from inner side	integral to membrane, integral to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion	membrane insertase activity		
YGR063C	SPT4	Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5p [Source:SGD;Acc:S000003295]	chromatin organization, chromatin silencing, chromosome segregation, mRNA processing, regulation of transcription from RNA polymerase I promoter, regulation of transcription, DNA-dependent, transcription elongation from RNA polymerase II promoter, transcription-coupled nucleotide-excision repair	DSIF complex, chromosome, centromeric region, kinetochore, nuclear chromosome, telomeric region, nucleus, rDNA heterochromatin, transcription elongation factor complex	metal ion binding, zinc ion binding		
YGR064W	YGR064W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C [Source:SGD;Acc:S000003296]					
YGR065C	VHT1	High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin [Source:SGD;Acc:S000003297]	biotin transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	biotin transporter activity, symporter activity		
YGR066C	YGR066C	Putative protein of unknown function [Source:SGD;Acc:S000003298]	biological_process	cellular_component	molecular_function		
YGR067C	YGR067C	Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p [Source:SGD;Acc:S000003299]	biological_process	cellular_component, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YGR068C	ART5	Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane [Source:SGD;Acc:S000003300]	endocytosis, ubiquitin-dependent endocytosis	cellular_component	ubiquitin protein ligase binding		
YGR068W-A	YGR068W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with the uncharacterized ORF YGR068C [Source:SGD;Acc:S000028637]					
YGR069W	YGR069W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003301]					
YGR070W	ROM1	GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP [Source:SGD;Acc:S000003302]	actin filament organization, budding cell bud growth, establishment of cell polarity, fungal-type cell wall organization, regulation of Rho protein signal transduction, small GTPase mediated signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity, signal transducer activity, small GTPase regulator activity		
YGR071C	YGR071C	Putative protein of unknown function; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus [Source:SGD;Acc:S000003303]	biological_process	nucleus	DNA binding, metal ion binding, molecular_function		
YGR072W	UPF3	Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance [Source:SGD;Acc:S000003304]	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, protein ubiquitination	cytoplasm, nucleus, polysome	molecular_function, nucleotide binding		
YGR073C	YGR073C	Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein [Source:SGD;Acc:S000003305]					
YGR074W	SMD1	Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1 [Source:SGD;Acc:S000003306]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, commitment complex, nucleus, ribonucleoprotein complex	RNA binding, mRNA binding		
YGR075C	PRP38	Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly [Source:SGD;Acc:S000003307]	RNA splicing, mRNA processing, spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	U4/U6 x U5 tri-snRNP complex, nucleus, ribonucleoprotein complex, spliceosomal complex	molecular_function		
YGR076C	MRPL25	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000003308]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YGR077C	PEX8	Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p [Source:SGD;Acc:S000003309]	peroxisome organization, protein targeting to peroxisome	extrinsic to intraperoxisomal membrane, peroxisomal matrix, peroxisomal membrane, peroxisome	peroxisome targeting sequence binding		
YGR078C	PAC10	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding [Source:SGD;Acc:S000003310]	protein folding, tubulin complex assembly	cytoplasm, prefoldin complex	tubulin binding, unfolded protein binding		
YGR079W	YGR079W	Putative protein of unknown function; YGR079W is not an essential gene [Source:SGD;Acc:S000003311]	biological_process	cellular_component	molecular_function		
YGR080W	TWF1	Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly [Source:SGD;Acc:S000003312]	actin polymerization or depolymerization, bipolar cellular bud site selection, sequestering of actin monomers	actin cortical patch, cytoplasm, cytoskeleton, intracellular, mating projection tip	actin binding, actin monomer binding		
YGR081C	SLX9	Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant [Source:SGD;Acc:S000003313]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, nucleolus, nucleus, preribosome, small subunit precursor	molecular_function		
YGR082W	TOM20	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins [Source:SGD;Acc:S000003314]	cytoplasmic tRNA import into mitochondrion, intracellular protein transport, mitochondrial outer membrane translocase complex assembly, protein import into mitochondrial matrix, protein targeting, protein transport, transport	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion	mitochondrion targeting sequence binding, protein channel activity		
YGR083C	GCD2	Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000003315]	cellular metabolic process, regulation of translation, regulation of translational initiation, translation	eukaryotic translation initiation factor 2B complex, guanyl-nucleotide exchange factor complex	enzyme regulator activity, guanyl-nucleotide exchange factor activity, translation initiation factor activity		
YGR084C	MRP13	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000003316]	mitochondrial translation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YGR085C	RPL11B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11 [Source:SGD;Acc:S000003317]	ribosomal large subunit assembly, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YGR086C	PIL1	Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria [Source:SGD;Acc:S000003318]	eisosome assembly, endocytosis, negative regulation of protein kinase activity, protein localization, response to heat	cytoplasm, eisosome, lipid particle, mitochondrial outer membrane, mitochondrion, plasma membrane enriched fraction	molecular_function		
YGR087C	PDC6	Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation [Source:SGD;Acc:S000003319]	L-phenylalanine catabolic process, aromatic amino acid family catabolic process to alcohol via Ehrlich pathway, branched chain family amino acid catabolic process, ethanol metabolic process, tryptophan catabolic process	cytoplasm	carboxy-lyase activity, catalytic activity, lyase activity, magnesium ion binding, metal ion binding, pyruvate decarboxylase activity, thiamine pyrophosphate binding, transferase activity		
YGR088W	CTT1	Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide [Source:SGD;Acc:S000003320]	cellular response to water deprivation, hydrogen peroxide catabolic process, oxidation-reduction process, response to oxidative stress, response to reactive oxygen species, response to stress	cytoplasm	catalase activity, heme binding, iron ion binding, metal ion binding, oxidoreductase activity, peroxidase activity		
YGR089W	NNF2	Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation [Source:SGD;Acc:S000003321]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, membrane fraction	molecular_function		
YGR090W	UTP22	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data [Source:SGD;Acc:S000003322]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, CURI complex, UTP-C complex, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	RNA binding, molecular_function		
YGR091W	PRP31	Splicing factor, component of the U4/U6-U5 snRNP complex [Source:SGD;Acc:S000003323]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome, spliceosomal snRNP assembly	U4/U6 x U5 tri-snRNP complex, mitochondrion, nucleus, ribonucleoprotein complex, spliceosomal complex	RNA binding, molecular_function		
YGR092W	DBF2	Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis [Source:SGD;Acc:S000003324]	cell cycle, nuclear division, protein phosphorylation, vacuolar acidification	cellular bud neck, spindle pole body	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YGR093W	YGR093W	Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus [Source:SGD;Acc:S000003325]	biological_process	nucleus	catalytic activity, molecular_function		
YGR094W	VAS1	Mitochondrial and cytoplasmic valyl-tRNA synthetase [Source:SGD;Acc:S000003326]	tRNA aminoacylation for protein translation, translation, valyl-tRNA aminoacylation	cytoplasm, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, valine-tRNA ligase activity		
YGR095C	RRP46	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) [Source:SGD;Acc:S000003327]	RNA processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ncRNA 3'-end processing, nonfunctional rRNA decay, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, polyadenylation-dependent snoRNA 3'-end processing, rRNA processing	cytoplasm, cytoplasmic exosome (RNase complex), exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleus	3'-5'-exoribonuclease activity, RNA binding, molecular_function		
YGR096W	TPC1	Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family [Source:SGD;Acc:S000003328]	thiamine pyrophosphate transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion	binding, thiamine transmembrane transporter activity		
YGR097W	ASK10	Component of RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; paralogous to Rgc1p [Source:SGD;Acc:S000003329]	cellular response to oxidative stress, positive regulation of glycerol transport	DNA-directed RNA polymerase II, holoenzyme, cytoplasm	protein binding		
YGR098C	ESP1	Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p [Source:SGD;Acc:S000003330]	apoptosis, chromosome segregation, mitotic sister chromatid segregation, negative regulation of protein phosphatase type 2A activity, proteolysis, regulation of exit from mitosis, regulation of mitotic spindle elongation	cytoplasm, cytoskeleton, mitochondrion, nucleus, spindle, spindle pole body	cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity		
YGR099W	TEL2	Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect [Source:SGD;Acc:S000003331]	protein localization to chromosome, telomere maintenance, telomere maintenance via telomerase	ASTRA complex, chromosome, telomeric region, nuclear telomere cap complex, nucleus	DNA binding, telomeric DNA binding		
YGR100W	MDR1	Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function [Source:SGD;Acc:S000003332]	intracellular protein transport, regulation of Rab GTPase activity	cytoplasm, intracellular, soluble fraction	GTPase activator activity, Rab GTPase activator activity, calcium ion binding		
YGR101W	PCP1	Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases [Source:SGD;Acc:S000003333]	mitochondrion organization, protein import into mitochondrial intermembrane space, signal peptide processing	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	hydrolase activity, peptidase activity, serine-type peptidase activity		
YGR102C	YGR102C	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria [Source:SGD;Acc:S000003334]	glutaminyl-tRNAGln biosynthesis via transamidation, translation	glutamyl-tRNA(Gln) amidotransferase complex, mitochondrion	ATP binding, glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, ligase activity, nucleotide binding		
YGR103W	NOP7	Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation [Source:SGD;Acc:S000003335]	cell cycle, cell proliferation, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis	PeBoW complex, intracellular, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor	molecular_function		
YGR104C	SRB5	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance [Source:SGD;Acc:S000003336]	regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus			
YGR105W	VMA21	Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) [Source:SGD;Acc:S000003337]	vacuolar proton-transporting V-type ATPase complex assembly	ER to Golgi transport vesicle membrane, ER-Golgi intermediate compartment membrane, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YGR106C	VOA1	Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval [Source:SGD;Acc:S000003338]	protein complex assembly	endoplasmic reticulum, endoplasmic reticulum membrane, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YGR107W	YGR107W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003339]					
YGR108W	CLB1	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome [Source:SGD;Acc:S000003340]	G2/M transition of mitotic cell cycle, cell cycle, cell division, meiotic G2/MI transition, mitosis, mitotic spindle organization in nucleus, positive regulation of spindle pole body separation, regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus	cyclin-dependent protein kinase regulator activity		
YGR109C	CLB6	B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 [Source:SGD;Acc:S000003341]	G1/S transition of mitotic cell cycle, cell cycle, cell division, positive regulation of DNA replication, premeiotic DNA replication, regulation of S phase of mitotic cell cycle, regulation of cyclin-dependent protein kinase activity	cellular_component, nucleus	cyclin-dependent protein kinase regulator activity		
YGR109W-A	YGR109W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007346]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YGR109W-B	YGR109W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007347]	DNA integration, DNA recombination, RNA-dependent DNA replication, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity, zinc ion binding		
YGR110W	CLD1	Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 [Source:SGD;Acc:S000003342]	cardiolipin metabolic process	mitochondrion	hydrolase activity, phospholipase A2 activity, transferase activity		
YGR111W	YGR111W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000003343]	regulation of cell size	cytoplasm, nucleus	molecular_function		
YGR112W	SHY1	Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome [Source:SGD;Acc:S000003344]	aerobic respiration, mitochondrial respiratory chain complex IV assembly	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	unfolded protein binding		
YGR113W	DAM1	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments [Source:SGD;Acc:S000003345]	cell cycle, cell division, chromosome segregation, mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization	DASH complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, kinetochore microtubule, microtubule, nucleus, spindle, spindle midzone	microtubule binding, structural constituent of cytoskeleton		
YGR114C	YGR114C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 [Source:SGD;Acc:S000003346]					
YGR115C	YGR115C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C [Source:SGD;Acc:S000003347]					
YGR116W	SPT6	Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region [Source:SGD;Acc:S000003348]	negative regulation of transcription from RNA polymerase II promoter, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, nucleosome assembly, regulation of transcription by chromatin organization, regulation of transcription from RNA polymerase II promoter, regulation of transcription from RNA polymerase II promoter in response to stress, regulation of transcription, DNA-dependent, transcription elongation from RNA polymerase II promoter	mitochondrion, nucleus, transcription elongation factor complex	hydrolase activity, acting on ester bonds, protein binding		
YGR117C	YGR117C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003349]	biological_process	cytoplasm	molecular_function, protein binding		
YGR118W	RPS23A	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal [Source:SGD;Acc:S000003350]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), regulation of translational fidelity, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome, small ribosomal subunit	structural constituent of ribosome		
YGR119C	NUP57	Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p [Source:SGD;Acc:S000003351]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein import into nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	Nic96 complex, membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YGR120C	COG2	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000003352]	CVT pathway, ER to Golgi vesicle-mediated transport, Golgi organization, intra-Golgi vesicle-mediated transport, macroautophagy, peroxisome degradation, protein transport, retrograde transport, vesicle recycling within Golgi, transport	Golgi apparatus, Golgi membrane, Golgi transport complex, membrane, peripheral to membrane of membrane fraction, soluble fraction	molecular_function		
YGR121C	MEP1	Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation [Source:SGD;Acc:S000003353]	ammonium transport, nitrogen utilization, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	ammonium transmembrane transporter activity		
YGR121W-A	YGR121W-A	Putative protein of unknown function [Source:SGD;Acc:S000028550]	biological_process	cellular_component	molecular_function		
YGR122C-A	YGR122C-A	Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W [Source:SGD;Acc:S000007240]					
YGR122W	YGR122W	Probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic [Source:SGD;Acc:S000003354]	negative regulation of transcription from RNA polymerase II promoter, nuclear-transcribed mRNA catabolic process, non-stop decay	cytoplasm	molecular_function		
YGR123C	PPT1	Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing [Source:SGD;Acc:S000003355]	protein dephosphorylation	cytoplasm, nucleus	binding, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity		
YGR124W	ASN2	Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway [Source:SGD;Acc:S000003356]	asparagine biosynthetic process, cellular amino acid biosynthetic process, glutamine metabolic process	cytoplasm	ATP binding, asparagine synthase (glutamine-hydrolyzing) activity, ligase activity, nucleotide binding		
YGR125W	YGR125W	Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole [Source:SGD;Acc:S000003357]	biological_process, transmembrane transport, transport	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function, transporter activity		
YGR126W	YGR126W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000003358]	biological_process	cytoplasm, nucleus	molecular_function		
YGR127W	YGR127W	Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response [Source:SGD;Acc:S000003359]	biological_process	cellular_component	molecular_function		
YGR128C	UTP8	Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000003360]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of transcription from RNA polymerase I promoter, rRNA processing, ribosome biogenesis, tRNA export from nucleus	90S preribosome, nucleolus, nucleus, rDNA heterochromatin, ribonucleoprotein complex, small-subunit processome, t-UTP complex	snoRNA binding, tRNA binding		
YGR129W	SYF2	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest [Source:SGD;Acc:S000003361]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	Prp19 complex, U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, U2-type post-mRNA release spliceosomal complex, U2-type prespliceosome, nucleus, spliceosomal complex	first spliceosomal transesterification activity, second spliceosomal transesterification activity		
YGR130C	YGR130C	Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; possible component of the eisosome; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) [Source:SGD;Acc:S000003362]	biological_process	cytoplasm, membrane raft	molecular_function		
YGR131W	FHN1	Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain [Source:SGD;Acc:S000003363]	establishment of protein localization in plasma membrane	integral to membrane, membrane, membrane raft	molecular_function		
YGR132C	PHB1	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation [Source:SGD;Acc:S000003364]	inner mitochondrial membrane organization, mitochondrion inheritance, mitochondrion morphogenesis, negative regulation of proteolysis, protein folding, replicative cell aging	membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YGR133W	PEX4	Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis [Source:SGD;Acc:S000003365]	peroxisome organization, post-translational protein modification, protein autoubiquitination, protein import into peroxisome matrix, receptor recycling, protein monoubiquitination, protein polyubiquitination, regulation of protein metabolic process	peroxisome	ATP binding, acid-amino acid ligase activity, ligase activity, nucleotide binding, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YGR134W	CAF130	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation [Source:SGD;Acc:S000003366]	regulation of transcription from RNA polymerase II promoter	CCR4-NOT core complex, cytoplasm, nucleus	molecular_function		
YGR135W	PRE9	Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform [Source:SGD;Acc:S000003367]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteasome core complex assembly, proteolysis involved in cellular protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, mitochondrion, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, molecular_function, peptidase activity, threonine-type endopeptidase activity		
YGR136W	LSB1	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization [Source:SGD;Acc:S000003368]	biological_process	cytoplasm, nucleus	molecular_function, protein binding		
YGR137W	YGR137W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003369]					
YGR138C	TPO2	Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily [Source:SGD;Acc:S000003370]	spermine transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane, vacuolar membrane	antiporter activity, spermine transmembrane transporter activity		
YGR139W	YGR139W	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003371]					
YGR140W	CBF2	Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo [Source:SGD;Acc:S000003372]	chromosome segregation, mitotic spindle elongation, septin ring assembly	CBF3 complex, chromosome, centromeric region, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, nucleus, spindle, spindle midzone, spindle pole body	DNA bending activity, DNA binding, centromeric DNA binding		
YGR141W	VPS62	Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins [Source:SGD;Acc:S000003373]	protein targeting to vacuole, protein transport, transport	cellular_component, integral to membrane, membrane	molecular_function		
YGR142W	BTN2	v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase [Source:SGD;Acc:S000003374]	amino acid transport, intracellular protein transport, regulation of pH, retrograde transport, endosome to Golgi	cytoplasm, cytosol, late endosome, perinuclear region of cytoplasm	SNARE binding		
YGR143W	SKN1	Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p [Source:SGD;Acc:S000003375]	1,6-beta-glucan biosynthetic process, cellular cell wall organization, fungal-type cell wall organization, sphingolipid biosynthetic process	integral to membrane, membrane	glucosidase activity		
YGR144W	THI4	Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents [Source:SGD;Acc:S000003376]	mitochondrial genome maintenance, thiamine biosynthetic process	cytosol, mitochondrion	molecular_function		
YGR145W	ENP2	Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p [Source:SGD;Acc:S000003377]	rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis	90S preribosome, nucleolus, nucleus	molecular_function, protein binding		
YGR146C	ECL1	Protein of unknown function, affects chronological lifespan; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000003378]	biological_process	cellular_component	molecular_function		
YGR146C-A	YGR146C-A	Putative protein of unknown function [Source:SGD;Acc:S000028638]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YGR147C	NAT2	Protein with an apparent role in acetylation of N-terminal methionine residues [Source:SGD;Acc:S000003379]	N-terminal peptidyl-methionine acetylation	cytoplasm, mitochondrion	acyltransferase activity, molecular_function, peptide alpha-N-acetyltransferase activity, transferase activity		
YGR148C	RPL24B	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate [Source:SGD;Acc:S000003380]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YGR149W	YGR149W	Putative protein of unknown function; predicted to be an integal membrane protein [Source:SGD;Acc:S000003381]	biological_process	integral to membrane, membrane	molecular_function		
YGR150C	CCM1	Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport [Source:SGD;Acc:S000003382]	RNA splicing, mRNA processing, mitochondrial RNA processing, mitochondrial genome maintenance, rRNA metabolic process	mitochondrion	rRNA binding		
YGR151C	YGR151C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C [Source:SGD;Acc:S000003383]					
YGR152C	RSR1	GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases [Source:SGD;Acc:S000003384]	axial cellular bud site selection, bipolar cellular bud site selection, cell cycle, cell division, cellular bud site selection, signal transduction, small GTPase mediated signal transduction	cellular bud neck, intracellular, membrane, plasma membrane	GTP binding, GTPase activity, nucleotide binding, signal transducer activity		
YGR153W	YGR153W	Putative protein of unknown function [Source:SGD;Acc:S000003385]	biological_process	cellular_component	molecular_function		
YGR154C	GTO1	Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization [Source:SGD;Acc:S000003386]	glutathione metabolic process	peroxisome	glutathione transferase activity, transferase activity		
YGR155W	CYS4	Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria [Source:SGD;Acc:S000003387]	cellular amino acid biosynthetic process, cysteine biosynthetic process, cysteine biosynthetic process from serine, cysteine biosynthetic process via cystathionine, hydrogen sulfide biosynthetic process, metabolic process, transsulfuration	cytoplasm, mitochondrion	catalytic activity, cystathionine beta-synthase activity, lyase activity, protein binding, pyridoxal phosphate binding		
YGR156W	PTI1	Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 [Source:SGD;Acc:S000003388]	mRNA cleavage, mRNA polyadenylation, mRNA processing, snoRNA 3'-end processing, termination of RNA polymerase II transcription, exosome-dependent, termination of RNA polymerase II transcription, poly(A)-coupled	mRNA cleavage and polyadenylation specificity factor complex, nucleus	RNA binding, nucleic acid binding, nucleotide binding		
YGR157W	CHO2	Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis [Source:SGD;Acc:S000003389]	phosphatidylcholine biosynthetic process, phospholipid biosynthetic process	integral to membrane, membrane, microsome	methyltransferase activity, phosphatidylethanolamine N-methyltransferase activity, transferase activity		
YGR158C	MTR3	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) [Source:SGD;Acc:S000003390]	RNA processing, U4 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nonfunctional rRNA decay, nuclear mRNA surveillance, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, polyadenylation-dependent snoRNA 3'-end processing, rRNA processing	cytoplasm, cytoplasmic exosome (RNase complex), exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleus	3'-5'-exoribonuclease activity, RNA binding, molecular_function		
YGR159C	NSR1	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis [Source:SGD;Acc:S000003391]	rRNA processing, response to stress, ribosomal small subunit assembly	mitochondrion, nucleolus, nucleus	DNA binding, RNA binding, nucleic acid binding, nucleotide binding, single-stranded DNA binding		
YGR160W	YGR160W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003392]					
YGR161C	RTS3	Putative component of the protein phosphatase type 2A complex [Source:SGD;Acc:S000003393]	biological_process	cytoplasm, nucleus	molecular_function		
YGR161C-C	YGR161C-C	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007367]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YGR161C-D	YGR161C-D	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007368]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YGR161W-A	YGR161W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007369]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YGR161W-B	YGR161W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007370]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YGR161W-C	YGR161W-C	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000029726]	biological_process	cellular_component	molecular_function		
YGR162W	TIF4631	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit [Source:SGD;Acc:S000003394]	RNA metabolic process, regulation of translation, ribosomal large subunit biogenesis, stress granule assembly, translation, translational initiation	cytoplasm, eukaryotic translation initiation factor 4F complex, mitochondrion, ribosome, stress granule	RNA binding, binding, protein binding, translation initiation factor activity		
YGR163W	GTR2	Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD [Source:SGD;Acc:S000003395]	autophagy, microautophagy, positive regulation of transcription from RNA polymerase II promoter, protein transport, transport	EGO complex, GSE complex, cytoplasm, late endosome membrane, membrane, nuclear chromatin, nucleus, vacuolar membrane, vacuole	GTP binding, nucleotide binding		
YGR164W	YGR164W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003396]					
YGR165W	MRPS35	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000003397]	mitochondrial translation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YGR166W	TRS65	Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response [Source:SGD;Acc:S000003398]	cellular cell wall organization, intra-Golgi vesicle-mediated transport, protein complex assembly, transport	Golgi apparatus, TRAPP complex, cytoplasm, trans-Golgi network	Rab guanyl-nucleotide exchange factor activity		
YGR167W	CLC1	Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component [Source:SGD;Acc:S000003399]	endocytosis, intracellular protein transport, vesicle-mediated transport	clathrin coat of coated pit, clathrin coat of trans-Golgi network vesicle, clathrin vesicle coat, coated pit, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane	calmodulin binding, structural molecule activity		
YGR168C	YGR168C	Putative protein of unknown function; YGR168C is not an essential gene [Source:SGD;Acc:S000003400]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YGR169C	PUS6	tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability [Source:SGD;Acc:S000003401]	RNA modification, pseudouridine synthesis, tRNA processing, tRNA pseudouridine synthesis	cytoplasm, mitochondrion	RNA binding, isomerase activity, pseudouridine synthase activity		
YGR169C-A	YGR169C-A	Putative protein of unknown function [Source:SGD;Acc:S000028521]	biological_process	cellular_component	molecular_function		
YGR170W	PSD2	Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine [Source:SGD;Acc:S000003402]	phosphatidylcholine biosynthetic process, phospholipid biosynthetic process	Golgi apparatus, Golgi stack, endosome, vacuole	carboxy-lyase activity, lyase activity, phosphatidylserine decarboxylase activity, protein binding		
YGR171C	MSM1	Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p [Source:SGD;Acc:S000003403]	methionyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, methionine-tRNA ligase activity, nucleotide binding		
YGR172C	YIP1	Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles [Source:SGD;Acc:S000003404]	ER to Golgi vesicle-mediated transport, protein transport, transport, vesicle fusion with Golgi apparatus, vesicle-mediated transport	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to Golgi membrane, integral to membrane, membrane	molecular_function		
YGR173W	RBG2	Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein [Source:SGD;Acc:S000003405]	translation	cytoplasm, intracellular	GTP binding, nucleotide binding		
YGR174C	CBP4	Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p [Source:SGD;Acc:S000003406]	mitochondrial respiratory chain complex III assembly	integral to membrane, integral to mitochondrial membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YGR174W-A	YGR174W-A	Putative protein of unknown function; predicted to have a role in cell budding based on computational "guilt by association" analysis [Source:SGD;Acc:S000028639]	biological_process	cellular_component	molecular_function		
YGR175C	ERG1	Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine [Source:SGD;Acc:S000003407]	ergosterol biosynthetic process, metabolic process, oxidation-reduction process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, lipid particle, membrane, microsome	drug binding, flavin adenine dinucleotide binding, oxidoreductase activity, squalene monooxygenase activity		
YGR176W	YGR176W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003408]					
YGR177C	ATF2	Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking [Source:SGD;Acc:S000003409]	alcohol metabolic process, response to toxin, steroid metabolic process, sterol acetylation	cytoplasm, endoplasmic reticulum, integral to endoplasmic reticulum membrane, membrane	acyltransferase activity, alcohol O-acetyltransferase activity, transferase activity		
YGR178C	PBP1	Component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation [Source:SGD;Acc:S000003410]	mRNA polyadenylation, positive regulation of translation, stress granule assembly	cytoplasm, mitochondrion, nucleus, polysome, stress granule	molecular_function		
YGR179C	OKP1	Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly [Source:SGD;Acc:S000003411]	attachment of spindle microtubules to kinetochore, cell cycle, cell division, chromosome segregation, meiosis, mitosis	COMA complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, kinetochore, nucleus	molecular_function		
YGR180C	RNR4	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits [Source:SGD;Acc:S000003412]	DNA replication, cofactor biosynthetic process, deoxyribonucleoside diphosphate metabolic process, deoxyribonucleotide biosynthetic process, oxidation-reduction process	cytoplasm, nucleus, ribonucleoside-diphosphate reductase complex	oxidoreductase activity, ribonucleoside-diphosphate reductase activity, transition metal ion binding		
YGR181W	TIM13	Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane [Source:SGD;Acc:S000003413]	protein import into mitochondrial inner membrane, protein targeting to mitochondrion, protein transport, transmembrane transport, transport	membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial intermembrane space protein transporter complex, mitochondrion	metal ion binding, protein transporter activity		
YGR182C	YGR182C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W [Source:SGD;Acc:S000003414]					
YGR183C	QCR9	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex [Source:SGD;Acc:S000003415]	aerobic respiration, electron transport chain, iron-sulfur cluster assembly, mitochondrial electron transport, ubiquinol to cytochrome c, transport	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial respiratory chain complex III, mitochondrion, respiratory chain	ubiquinol-cytochrome-c reductase activity		
YGR184C	UBR1	E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS) [Source:SGD;Acc:S000003416]	cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process, protein catabolic process, protein polyubiquitination, regulation of dipeptide transport, ubiquitin-dependent protein catabolic process via the N-end rule pathway	cytoplasm, proteasome regulatory particle, base subcomplex	ligase activity, metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YGR185C	TYS1	Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies [Source:SGD;Acc:S000003417]	tRNA aminoacylation for protein translation, translation, tyrosyl-tRNA aminoacylation	cytoplasm, nucleus	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, tyrosine-tRNA ligase activity		
YGR186W	TFG1	TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 [Source:SGD;Acc:S000003418]	transcription initiation from RNA polymerase II promoter	nucleus, transcription factor TFIIF complex	DNA binding, catalytic activity		
YGR187C	HGH1	Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16) [Source:SGD;Acc:S000003419]	biological_process	cytoplasm	binding, molecular_function		
YGR188C	BUB1	Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p [Source:SGD;Acc:S000003420]	cell cycle, cell cycle checkpoint, mitotic cell cycle spindle assembly checkpoint, protein localization to kinetochore, protein phosphorylation, sister chromatid biorientation	condensed nuclear chromosome kinetochore, condensed nuclear chromosome, centromeric region, kinetochore, nucleus	ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YGR189C	CRH1	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress [Source:SGD;Acc:S000003421]	carbohydrate metabolic process, cell wall chitin metabolic process, cellular cell wall organization, fungal-type cell wall organization, metabolic process	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, incipient cellular bud site, membrane	hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, transferase activity, transferring glycosyl groups		
YGR190C	YGR190C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W [Source:SGD;Acc:S000003422]					
YGR191W	HIP1	High-affinity histidine permease, also involved in the transport of manganese ions [Source:SGD;Acc:S000003423]	amino acid transport, histidine transport, manganese ion transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	amino acid transmembrane transporter activity, high affinity L-histidine transmembrane transporter activity		
YGR192C	TDH3	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall [Source:SGD;Acc:S000003424]	apoptosis, gluconeogenesis, glucose metabolic process, glycolysis, metabolic process, oxidation-reduction process	cytoplasm, fungal-type cell wall, lipid particle, mitochondrion, plasma membrane enriched fraction	NAD binding, binding, catalytic activity, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, glyceraldehyde-3-phosphate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor		
YGR193C	PDX1	Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core [Source:SGD;Acc:S000003425]	acetyl-CoA biosynthetic process from pyruvate, metabolic process	mitochondrial matrix, mitochondrial pyruvate dehydrogenase complex, mitochondrion	acyltransferase activity, structural molecule activity		
YGR194C	XKS1	Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains [Source:SGD;Acc:S000003426]	D-xylose metabolic process, carbohydrate metabolic process, xylulose catabolic process	cytoplasm	ATP binding, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity, xylulokinase activity		
YGR195W	SKI6	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4) [Source:SGD;Acc:S000003427]	RNA processing, U1 snRNA 3'-end processing, U4 snRNA 3'-end processing, U5 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nonfunctional rRNA decay, nuclear mRNA surveillance, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, polyadenylation-dependent snoRNA 3'-end processing, rRNA catabolic process, rRNA processing	cytoplasm, cytoplasmic exosome (RNase complex), exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleus	3'-5'-exoribonuclease activity, RNA binding, molecular_function		
YGR196C	FYV8	Protein of unknown function, required for survival upon exposure to K1 killer toxin [Source:SGD;Acc:S000003428]	biological_process	cytoplasm	molecular_function		
YGR197C	SNG1	Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance [Source:SGD;Acc:S000003429]	nucleobase, nucleoside, nucleotide and nucleic acid transport	integral to membrane, membrane, plasma membrane	molecular_function		
YGR198W	YPP1	Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene [Source:SGD;Acc:S000003430]	endocytosis, protein targeting to vacuole, receptor-mediated endocytosis, response to pheromone	actin cortical patch, cytoplasm, cytosol, endosome, membrane, plasma membrane, ribosome	binding, molecular_function		
YGR199W	PMT6	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases [Source:SGD;Acc:S000003431]	protein O-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YGR200C	ELP2	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin [Source:SGD;Acc:S000003432]	protein transport, protein urmylation, regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification, transport	Elongator holoenzyme complex, cytoplasm, nucleus	molecular_function, protein binding		
YGR201C	YGR201C	Putative protein of unknown function [Source:SGD;Acc:S000003433]	biological_process	cellular_component	molecular_function		
YGR202C	PCT1	Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding [Source:SGD;Acc:S000003434]	CDP-choline pathway, biosynthetic process, phosphatidylcholine biosynthetic process, phospholipid biosynthetic process	Golgi apparatus, membrane, nuclear envelope, nucleus	catalytic activity, choline-phosphate cytidylyltransferase activity, nucleotidyltransferase activity, transferase activity		
YGR203W	YCH1	Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000003435]	dephosphorylation	cytoplasm, nucleus	phosphatase activity, protein tyrosine phosphatase activity, thiosulfate sulfurtransferase activity		
YGR204C-A	YGR204C-A	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028640]	biological_process	cellular_component	molecular_function		
YGR204W	ADE3	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine [Source:SGD;Acc:S000003436]	cellular amino acid biosynthetic process, folic acid-containing compound biosynthetic process, folic acid-containing compound metabolic process, histidine biosynthetic process, metabolic process, methionine biosynthetic process, one-carbon metabolic process, oxidation-reduction process, purine base biosynthetic process, purine nucleotide biosynthetic process	cytoplasm, nucleus	ATP binding, binding, catalytic activity, formate-tetrahydrofolate ligase activity, hydrolase activity, ligase activity, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, nucleotide binding, oxidoreductase activity		
YGR205W	YGR205W	ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases [Source:SGD;Acc:S000003437]	biological_process	cytoplasm, nucleus	ATP binding, kinase activity, nucleotide binding, transferase activity		
YGR206W	MVB12	ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin [Source:SGD;Acc:S000003438]	endosome transport via multivesicular body sorting pathway, negative regulation of protein complex assembly, protein targeting to vacuole, protein transport, transport	ESCRT I complex, cytoplasm, cytosol, endosome, late endosome membrane, membrane	ubiquitin binding		
YGR207C	CIR1	Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response [Source:SGD;Acc:S000003439]	biological_process, electron transport chain, transport	mitochondrial matrix, mitochondrion	electron carrier activity, molecular_function		
YGR208W	SER2	Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source [Source:SGD;Acc:S000003440]	L-serine biosynthetic process, cellular amino acid biosynthetic process, metabolic process	cytoplasm, nucleus	catalytic activity, hydrolase activity, metal ion binding, phosphatase activity, phosphoserine phosphatase activity		
YGR209C	TRX2	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance [Source:SGD;Acc:S000003441]	ER to Golgi vesicle-mediated transport, cell redox homeostasis, cellular response to oxidative stress, deoxyribonucleotide biosynthetic process, electron transport chain, glycerol ether metabolic process, protein deglutathionylation, protein transport, regulation of DNA replication, retrograde vesicle-mediated transport, Golgi to ER, sulfate assimilation, transport, vacuole fusion, non-autophagic, vacuole inheritance	Golgi apparatus, Golgi membrane, cytoplasm, cytosol, fungal-type vacuole, membrane, nucleus	disulfide oxidoreductase activity, electron carrier activity, protein disulfide oxidoreductase activity		
YGR210C	YGR210C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003442]	biological_process	cytoplasm, intracellular	GTP binding, molecular_function, nucleotide binding		
YGR211W	ZPR1	Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p) [Source:SGD;Acc:S000003443]	cellular response to starvation, regulation of mitotic cell cycle	cytoplasm, nucleus	metal ion binding, protein binding, zinc ion binding		
YGR212W	SLI1	N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin [Source:SGD;Acc:S000003444]	alcohol metabolic process, response to drug	endoplasmic reticulum, nuclear envelope, plasma membrane	N-acetyltransferase activity, acyltransferase activity, alcohol O-acetyltransferase activity, transferase activity		
YGR213C	RTA1	Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein [Source:SGD;Acc:S000003445]	biological_process, response to stress	integral to membrane, membrane	molecular_function		
YGR214W	RPS0A	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal [Source:SGD;Acc:S000003446]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA export from nucleus, rRNA processing, ribosomal small subunit assembly, ribosome biogenesis, translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome, small ribosomal subunit	structural constituent of ribosome		
YGR215W	RSM27	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000003447]	mitochondrial translation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YGR216C	GPI1	Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs [Source:SGD;Acc:S000003448]	GPI anchor biosynthetic process	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, integral to membrane, membrane	UDP-glycosyltransferase activity, phosphatidylinositol N-acetylglucosaminyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YGR217W	CCH1	Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together [Source:SGD;Acc:S000003449]	calcium ion transport, ion transport, response to stress, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	calcium channel activity, ion channel activity, voltage-gated calcium channel activity, voltage-gated ion channel activity		
YGR218W	CRM1	Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin [Source:SGD;Acc:S000003450]	intracellular protein transport, mRNA export from nucleus, protein export from nucleus, protein localization to kinetochore, protein transport, ribosomal large subunit export from nucleus, transport	cytoplasm, kinetochore, nucleus, perinuclear region of cytoplasm, spindle pole body	binding, protein transporter activity		
YGR219W	YGR219W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C [Source:SGD;Acc:S000003451]					
YGR220C	MRPL9	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000003452]	translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YGR221C	TOS2	Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000003453]	budding cell bud growth	cellular bud membrane, cellular bud neck, cellular bud tip, integral to membrane, membrane, plasma membrane	molecular_function		
YGR222W	PET54	Mitochondrial inner membrane protein that binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing [Source:SGD;Acc:S000003454]	Group I intron splicing, mRNA processing, positive regulation of mitochondrial translation, regulation of translation	membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion	RNA binding, nucleic acid binding, nucleotide binding, translation regulator activity		
YGR223C	HSV2	Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization [Source:SGD;Acc:S000003455]	piecemeal microautophagy of nucleus	cytoplasm, endosome, endosome membrane, fungal-type vacuole, late endosome membrane, membrane, peripheral to membrane of membrane fraction	phosphatidylinositol binding, protein binding		
YGR224W	AZR1	Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole [Source:SGD;Acc:S000003456]	azole transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	azole transporter activity		
YGR225W	AMA1	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis [Source:SGD;Acc:S000003457]	ascospore formation, ascospore wall assembly, cell cycle, cell division, meiosis, meiosis I, positive regulation of protein catabolic process	anaphase-promoting complex	enzyme activator activity, protein binding		
YGR226C	YGR226C	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W [Source:SGD;Acc:S000003458]					
YGR227W	DIE2	Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 [Source:SGD;Acc:S000003459]	dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups		
YGR228W	YGR228W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C [Source:SGD;Acc:S000003460]					
YGR229C	SMI1	Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity [Source:SGD;Acc:S000003461]	cell wall biogenesis, cellular cell wall organization, regulation of fungal-type cell wall biogenesis, regulation of mitotic cell cycle	cellular bud neck, incipient cellular bud site, mating projection tip, nucleus	DNA binding, molecular_function		
YGR230W	BNS1	Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis [Source:SGD;Acc:S000003462]	cell cycle, meiosis	cellular_component	molecular_function		
YGR231C	PHB2	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation [Source:SGD;Acc:S000003463]	mitochondrion inheritance, negative regulation of proteolysis, protein folding, replicative cell aging	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YGR232W	NAS6	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6 [Source:SGD;Acc:S000003464]	proteasome regulatory particle assembly, proteolysis	cytosol, nucleus, proteasome regulatory particle	molecular_function, protein binding		
YGR233C	PHO81	Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p [Source:SGD;Acc:S000003465]	lipid metabolic process, phosphate metabolic process	cytoplasm, nucleus	cyclin-dependent protein kinase inhibitor activity, phosphoric diester hydrolase activity, protein binding		
YGR234W	YHB1	Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses [Source:SGD;Acc:S000003466]	oxidation-reduction process, oxygen transport, response to stress, response to toxin	cytoplasm, cytosol, mitochondrial matrix, mitochondrion	heme binding, iron ion binding, metal ion binding, nitric oxide dioxygenase activity, nitric oxide reductase activity, oxidoreductase activity, oxygen binding		
YGR235C	YGR235C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003467]	biological_process	mitochondrion	molecular_function		
YGR236C	SPG1	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003468]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YGR237C	YGR237C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003469]	biological_process	cytoplasm	molecular_function		
YGR238C	KEL2	Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate [Source:SGD;Acc:S000003470]	conjugation with cellular fusion, negative regulation of exit from mitosis	cellular bud neck, cellular bud tip, mating projection tip	molecular_function		
YGR239C	PEX21	Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p [Source:SGD;Acc:S000003471]	positive regulation of protein binding, protein import into peroxisome matrix	cytoplasm, cytosol, membrane, peroxisomal membrane, peroxisome	protein binding		
YGR240C	PFK1	Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes [Source:SGD;Acc:S000003472]	glycolysis	6-phosphofructokinase complex, cytoplasm, mitochondrion	6-phosphofructokinase activity, ATP binding, catalytic activity, kinase activity, metal ion binding, nucleotide binding, transferase activity		
YGR240C-A	YGR240C-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028551]	biological_process	cellular_component	molecular_function		
YGR241C	YAP1802	Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family [Source:SGD;Acc:S000003473]	clathrin coat assembly, endocytosis	actin cortical patch, cellular bud, cellular bud neck, clathrin coat, cytoplasm, membrane, plasma membrane	1-phosphatidylinositol binding, clathrin binding, phospholipid binding		
YGR242W	YGR242W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C [Source:SGD;Acc:S000003474]					
YGR243W	FMP43	Putative protein of unknown function; expression regulated by osmotic and alkaline stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003475]	biological_process, response to stress	mitochondrion	molecular_function		
YGR244C	LSC2	Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate [Source:SGD;Acc:S000003476]	metabolic process, succinyl-CoA metabolic process, tricarboxylic acid cycle	mitochondrion	ATP binding, catalytic activity, ligase activity, nucleotide binding, succinate-CoA ligase (ADP-forming) activity		
YGR245C	SDA1	Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis [Source:SGD;Acc:S000003477]	actin cytoskeleton organization, cell cycle, protein transport, ribosomal large subunit biogenesis, ribosomal large subunit export from nucleus, ribosome biogenesis, transport, traversing start control point of mitotic cell cycle	nucleolus, nucleus	binding, molecular_function		
YGR246C	BRF1	TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB [Source:SGD;Acc:S000003478]	RNA polymerase III transcriptional preinitiation complex assembly, negative regulation of protein homodimerization activity, regulation of transcription, DNA-dependent, transcription from RNA polymerase III promoter, transcription initiation, DNA-dependent, translational initiation, transposon integration	nucleus, transcription factor TFIIIB complex	DNA binding, metal ion binding, translation initiation factor activity, zinc ion binding		
YGR247W	CPD1	Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression [Source:SGD;Acc:S000003479]	RNA metabolic process, cyclic nucleotide metabolic process	Golgi apparatus, clathrin-coated vesicle, intracellular	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity, catalytic activity, cyclic-nucleotide phosphodiesterase activity, hydrolase activity		
YGR248W	SOL4	6-phosphogluconolactonase with similarity to Sol3p [Source:SGD;Acc:S000003480]	carbohydrate metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch	cytoplasm, cytosol, nucleus	6-phosphogluconolactonase activity, hydrolase activity		
YGR249W	MGA1	Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants [Source:SGD;Acc:S000003481]	filamentous growth, regulation of transcription, DNA-dependent	nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YGR250C	YGR250C	Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid [Source:SGD;Acc:S000003482]	biological_process	cytoplasm, stress granule	RNA binding, nucleic acid binding, nucleotide binding		
YGR251W	YGR251W	Essential protein required for maturation of 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus [Source:SGD;Acc:S000003483]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleolus, nucleus	molecular_function		
YGR252W	GCN5	Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily [Source:SGD;Acc:S000003484]	chromatin modification, histone acetylation, metabolic process, positive regulation of transcription elongation from RNA polymerase II promoter, regulation of transcription by chromatin organization	Ada2/Gcn5/Ada3 transcription activator complex, SAGA complex, SLIK (SAGA-like) complex, chromosome, centromeric region, nucleus	H3 histone acetyltransferase activity, N-acetyltransferase activity, acyltransferase activity, histone acetyl-lysine binding, histone acetyltransferase activity, protein binding, transcription coactivator activity, transferase activity		
YGR253C	PUP2	Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta [Source:SGD;Acc:S000003485]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteolysis involved in cellular protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, mitochondrion, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, molecular_function, peptidase activity, threonine-type endopeptidase activity		
YGR254W	ENO1	Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose [Source:SGD;Acc:S000003486]	gluconeogenesis, glycolysis, regulation of vacuole fusion, non-autophagic	cytoplasm, fungal-type vacuole, mitochondrion, phosphopyruvate hydratase complex, plasma membrane enriched fraction	lyase activity, magnesium ion binding, metal ion binding, phosphopyruvate hydratase activity		
YGR255C	COQ6	Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes [Source:SGD;Acc:S000003487]	metabolic process, oxidation-reduction process, ubiquinone biosynthetic process	membrane, mitochondrial inner membrane, mitochondrion	flavin adenine dinucleotide binding, molecular_function, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen		
YGR256W	GND2	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone [Source:SGD;Acc:S000003488]	metabolic process, oxidation-reduction process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch	cytosol, plasma membrane enriched fraction	NADP binding, binding, catalytic activity, coenzyme binding, oxidoreductase activity, phosphogluconate dehydrogenase (decarboxylating) activity		
YGR257C	MTM1	Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor [Source:SGD;Acc:S000003489]	manganese ion transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, metallochaperone activity, transporter activity		
YGR258C	RAD2	Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein [Source:SGD;Acc:S000003490]	DNA repair, nucleotide-excision repair, nucleotide-excision repair, DNA incision, 3'-to lesion, response to DNA damage stimulus, transcription from RNA polymerase II promoter	nucleotide-excision repair factor 3 complex, nucleus	DNA binding, catalytic activity, endonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding, nuclease activity, single-stranded DNA binding, single-stranded DNA specific endodeoxyribonuclease activity		
YGR259C	YGR259C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W [Source:SGD;Acc:S000003491]					
YGR260W	TNA1	High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) [Source:SGD;Acc:S000003492]	nicotinamide mononucleotide transport, transmembrane transport, transport	integral to membrane, integral to plasma membrane, membrane, mitochondrion	nicotinamide mononucleotide transmembrane transporter activity		
YGR261C	APL6	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools [Source:SGD;Acc:S000003493]	Golgi to vacuole transport, intracellular protein transport, protein transport, transport, vesicle-mediated transport	AP-3 adaptor complex, Golgi apparatus, clathrin coated vesicle membrane, cytoplasmic vesicle, membrane, membrane coat	binding, molecular_function		
YGR262C	BUD32	Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription [Source:SGD;Acc:S000003494]	cellular bud site selection, lipopolysaccharide biosynthetic process, positive regulation of transcription from RNA polymerase II promoter, protein phosphorylation, telomere maintenance, threonylcarbamoyladenosine metabolic process	EKC/KEOPS complex, chromosome, telomeric region, cytoplasm, membrane, nucleus	ATP binding, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity		
YGR263C	SAY1	Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum [Source:SGD;Acc:S000003495]	response to toxin, sterol deacetylation, sterol metabolic process	endoplasmic reticulum, endoplasmic reticulum lumen, integral to membrane, membrane	steryl deacetylase activity		
YGR264C	MES1	Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs [Source:SGD;Acc:S000003496]	methionyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, methionyl glutamyl tRNA synthetase complex	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, methionine-tRNA ligase activity, nucleotide binding		
YGR265W	YGR265W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase [Source:SGD;Acc:S000003497]					
YGR266W	YGR266W	Protein of unknown function, predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane [Source:SGD;Acc:S000003498]	biological_process	mitochondrial outer membrane, mitochondrion, plasma membrane	molecular_function		
YGR267C	FOL2	GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway [Source:SGD;Acc:S000003499]	folic acid-containing compound biosynthetic process, tetrahydrobiopterin biosynthetic process, tetrahydrofolate biosynthetic process	cytoplasm, nucleus	GTP binding, GTP cyclohydrolase I activity, catalytic activity, hydrolase activity, metal ion binding, nucleotide binding		
YGR268C	HUA1	Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly [Source:SGD;Acc:S000003500]	biological_process	cytoplasm	molecular_function		
YGR269W	YGR269W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C [Source:SGD;Acc:S000003501]					
YGR270C-A	YGR270C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W [Source:SGD;Acc:S000028641]					
YGR270W	YTA7	Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000003502]	cellular protein localization, positive regulation of isoprenoid metabolic process	extrinsic to endoplasmic reticulum membrane, nucleus	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding, protein binding		
YGR271C-A	EFG1	Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus [Source:SGD;Acc:S000007608]	G1 phase of mitotic cell cycle, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing	nucleolus, nucleus	molecular_function		
YGR271W	SLH1	Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses [Source:SGD;Acc:S000003503]	regulation of translation, response to virus, translation	cytoplasm, polysomal ribosome	ATP binding, ATP-dependent helicase activity, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleoside-triphosphatase activity, nucleotide binding		
YGR273C	YGR273C	Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene [Source:SGD;Acc:S000003505]	biological_process	cellular_component	molecular_function		
YGR274C	TAF1	TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression [Source:SGD;Acc:S000003506]	RNA polymerase II transcriptional preinitiation complex assembly, chromatin modification	nucleus, transcription factor TFIID complex	TBP-class protein binding, acyltransferase activity, chromatin binding, histone acetyltransferase activity, nucleic acid binding, protein complex scaffold, transferase activity, zinc ion binding		
YGR275W	RTT102	Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition [Source:SGD;Acc:S000003507]	chromatin remodeling, chromosome segregation, nucleosome disassembly, transcription elongation from RNA polymerase II promoter	RSC complex, SWI/SNF complex, nucleus	molecular_function		
YGR276C	RNH70	3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts [Source:SGD;Acc:S000003508]	U5 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), generation of mature 3'-end of 5S rRNA generated by RNA polymerase III, rRNA processing, ribosome biogenesis, tRNA 3'-trailer cleavage, exonucleolytic, tRNA processing	intracellular, nucleus	3'-5' exonuclease activity, 3'-5'-exoribonuclease activity, RNA binding, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding		
YGR277C	CAB4	Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved [Source:SGD;Acc:S000003509]	biosynthetic process, coenzyme A biosynthetic process	cytoplasm, nucleus	ATP binding, nucleotide binding, nucleotidyltransferase activity, pantetheine-phosphate adenylyltransferase activity, transferase activity		
YGR278W	CWC22	Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein [Source:SGD;Acc:S000003510]	RNA metabolic process, RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U2-type catalytic step 1 spliceosome, U2-type spliceosomal complex, cytoplasm, nucleus, spliceosomal complex	binding, molecular_function, protein binding		
YGR279C	SCW4	Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating [Source:SGD;Acc:S000003511]	carbohydrate metabolic process, cellular cell wall organization, conjugation with cellular fusion, metabolic process	cell wall, extracellular region, fungal-type cell wall	catalytic activity, cation binding, glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds		
YGR280C	PXR1	Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain [Source:SGD;Acc:S000003512]	box C/D snoRNA 3'-end processing, negative regulation of telomere maintenance via telomerase, rRNA processing, ribosome biogenesis	intracellular, nucleolus, nucleoplasm, nucleus	nucleic acid binding, telomerase inhibitor activity		
YGR281W	YOR1	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) [Source:SGD;Acc:S000003513]	response to drug, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, plasma membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding, xenobiotic-transporting ATPase activity		
YGR282C	BGL2	Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance [Source:SGD;Acc:S000003514]	carbohydrate metabolic process, cellular cell wall organization, fungal-type cell wall organization, metabolic process	cell wall, extracellular region, fungal-type cell wall	1,3-beta-glucanosyltransferase activity, catalytic activity, cation binding, chitin binding, glucan endo-1,3-beta-D-glucosidase activity, glucan exo-1,3-beta-glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds		
YGR283C	YGR283C	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus [Source:SGD;Acc:S000003515]	biological_process	nucleolus, ribosome	molecular_function		
YGR284C	ERV29	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo [Source:SGD;Acc:S000003516]	ER to Golgi vesicle-mediated transport	ER to Golgi transport vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YGR285C	ZUO1	Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p [Source:SGD;Acc:S000003517]	protein folding, rRNA processing, regulation of translational fidelity, ribosomal subunit export from nucleus	cytoplasm, mitochondrion, nucleolus, ribosome	DNA binding, heat shock protein binding, unfolded protein binding		
YGR286C	BIO2	Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant [Source:SGD;Acc:S000003518]	biotin biosynthetic process, cofactor metabolic process, metabolic process	mitochondrion	2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, biotin synthase activity, catalytic activity, iron-sulfur cluster binding, metal ion binding, transferase activity		
YGR287C	IMA1	Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization; has specificity for isomaltose, palatinose, and methyl-alpha-glucoside; member of the IMA isomaltase family [Source:SGD;Acc:S000003519]	carbohydrate metabolic process, disaccharide catabolic process, maltose metabolic process, metabolic process	mitochondrion, ribosome	catalytic activity, cation binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, oligo-1,6-glucosidase activity		
YGR288W	MAL13	MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C [Source:SGD;Acc:S000003520]	cellular carbohydrate metabolic process, maltose metabolic process, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YGR289C	MAL11	Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization [Source:SGD;Acc:S000003521]	carbohydrate transport, disaccharide catabolic process, maltose metabolic process, maltose transport, transmembrane transport, transport, trehalose transport	integral to membrane, membrane, plasma membrane	alpha-glucoside:hydrogen symporter activity, maltose:hydrogen symporter activity, substrate-specific transmembrane transporter activity, symporter activity, transporter activity, trehalose transmembrane transporter activity		
YGR290W	YGR290W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) [Source:SGD;Acc:S000003522]					
YGR291C	YGR291C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003523]					
YGR292W	MAL12	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose [Source:SGD;Acc:S000003524]	carbohydrate metabolic process, maltose catabolic process, maltose metabolic process, metabolic process, sucrose catabolic process	plasma membrane enriched fraction	alpha-glucosidase activity, catalytic activity, cation binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, maltose alpha-glucosidase activity, sucrose alpha-glucosidase activity		
YGR293C	YGR293C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W [Source:SGD;Acc:S000003525]					
YGR294W	PAU12	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000003526]	biological_process, response to stress	cellular_component, integral to membrane, membrane	molecular_function		
YGR295C	COS6	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000003527]	biological_process	fungal-type vacuole, integral to membrane, membrane	molecular_function		
YGR296C-A	YGR296C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL07R [Source:SGD;Acc:S000028642]					
YGR296C-B	YGR296C-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; contained completely within TEL07R [Source:SGD;Acc:S000028643]					
YGR296W	YRF1-3	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000003528]	telomere maintenance via recombination	nucleus	ATP binding, ATP-dependent helicase activity, DNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YHL001W	RPL14B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein [Source:SGD;Acc:S000000993]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YHL002C-A	YHL002C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028770]					
YHL002W	HSE1	Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes [Source:SGD;Acc:S000000994]	intracellular protein transport, late endosome to vacuole transport, protein targeting to vacuole, protein transport, transport	ESCRT-0 complex, endosome, endosome membrane, membrane	protein binding, ubiquitin binding		
YHL003C	LAG1	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p [Source:SGD;Acc:S000000995]	ceramide biosynthetic process, lipid biosynthetic process, lipid metabolic process, replicative cell aging	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	sphingosine N-acyltransferase activity, transferase activity		
YHL004W	MRP4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000000996]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome, small ribosomal subunit	structural constituent of ribosome, tRNA binding		
YHL005C	YHL005C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W [Source:SGD;Acc:S000000997]					
YHL006C	SHU1	Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p [Source:SGD;Acc:S000000998]	DNA recombination, recombinational repair	nucleus	molecular_function		
YHL006W-A	YHL006W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028771]					
YHL007C	STE20	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p [Source:SGD;Acc:S000000999]	activation of MAPKKK activity, auxin biosynthetic process, cell cycle, cellular bud site selection, invasive growth in response to glucose limitation, negative regulation of gene expression, osmosensory signaling pathway via Sho1 osmosensor, pheromone-dependent signal transduction involved in conjugation with cellular fusion, positive regulation of apoptosis, protein phosphorylation, pseudohyphal growth, regulation of exit from mitosis, response to pheromone, signal transduction involved in filamentous growth, sterol import, stress granule assembly, vacuole inheritance	cytoplasm, incipient cellular bud site, mating projection tip, nucleus, plasma membrane enriched fraction	ATP binding, MAP kinase kinase kinase kinase activity, histone serine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YHL008C	YHL008C	Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole [Source:SGD;Acc:S000001000]	chloride transport, transport	fungal-type vacuole, integral to membrane, membrane	transporter activity		
YHL009C	YAP3	Basic leucine zipper (bZIP) transcription factor [Source:SGD;Acc:S000001001]	regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	cytoplasm, nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YHL009W-A	YHL009W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007371]	transposition, RNA-mediated	retrotransposon nucleocapsid	RNA binding, nucleic acid binding, zinc ion binding		
YHL009W-B	YHL009W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007372]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease activity, transferase activity, zinc ion binding		
YHL010C	ETP1	Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences [Source:SGD;Acc:S000001002]	response to ethanol	cellular_component, cytoplasm	metal ion binding, nuclear localization sequence binding, protein binding, ubiquitin binding, zinc ion binding		
YHL011C	PRS3	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [Source:SGD;Acc:S000001003]	5-phosphoribose 1-diphosphate biosynthetic process, cellular biosynthetic process, fungal-type cell wall organization, nucleoside metabolic process, nucleotide biosynthetic process, regulation of cell size, ribonucleoside monophosphate biosynthetic process	cytoplasm	ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, ribose phosphate diphosphokinase activity, transferase activity		
YHL012W	YHL012W	Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase [Source:SGD;Acc:S000001004]	biological_process, metabolic process	cellular_component	UTP:glucose-1-phosphate uridylyltransferase activity, molecular_function, nucleotidyltransferase activity, transferase activity		
YHL013C	OTU2	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization [Source:SGD;Acc:S000001005]	biological_process	cytoplasm, ribosome	molecular_function		
YHL014C	YLF2	Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001006]	biological_process	intracellular, mitochondrion	GTP binding, nucleotide binding		
YHL015W	RPS20	Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins [Source:SGD;Acc:S000001007]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome, small ribosomal subunit	RNA binding, structural constituent of ribosome		
YHL015W-A	YHL015W-A	Putative protein of unknown function [Source:SGD;Acc:S000028828]	biological_process	cellular_component	molecular_function		
YHL016C	DUR3	Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway [Source:SGD;Acc:S000001008]	ion transport, putrescine transport, sodium ion transport, spermidine transport, transmembrane transport, transport, urea catabolic process, urea transport	integral to membrane, membrane, plasma membrane	putrescine transmembrane transporter activity, spermidine transmembrane transporter activity, transporter activity, urea transmembrane transporter activity		
YHL017W	YHL017W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles [Source:SGD;Acc:S000001009]	biological_process	Golgi apparatus, clathrin-coated vesicle, integral to membrane, membrane	molecular_function		
YHL018W	YHL018W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000001010]	biological_process, tetrahydrobiopterin biosynthetic process	mitochondrion	4-alpha-hydroxytetrahydrobiopterin dehydratase activity, lyase activity, molecular_function		
YHL019C	APM2	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport [Source:SGD;Acc:S000001011]	Golgi to vacuole transport, intracellular protein transport, transport, vesicle-mediated transport	AP-1 adaptor complex, clathrin adaptor complex, coated pit, membrane	clathrin binding, protein binding		
YHL019W-A	YHL019W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene APM2/YHL019C [Source:SGD;Acc:S000028772]					
YHL020C	OPI1	Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance [Source:SGD;Acc:S000001012]	endoplasmic reticulum unfolded protein response, negative regulation of transcription from RNA polymerase II promoter, phospholipid biosynthetic process, positive regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum, nuclear envelope, nuclear membrane, nucleoplasm, nucleus	DNA binding, transcription corepressor activity		
YHL021C	AIM17	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000001013]	biological_process, oxidation-reduction process	mitochondrion	metal ion binding, molecular_function, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen		
YHL022C	SPO11	Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation [Source:SGD;Acc:S000001014]	DNA metabolic process, meiosis, meiotic DNA double-strand break formation, sporulation resulting in formation of a cellular spore	chromosome, nuclear chromosome, nucleus	ATP binding, DNA binding, catalytic activity, endodeoxyribonuclease activity, producing 3'-phosphomonoesters, hydrolase activity		
YHL023C	NPR3	Component, with Npr2p, of an evolutionarily conserved complex that mediates downregulation of TOR Complex 1 activity in response to amino acid limitation; null mutant displays delayed meiotic DNA replication and double-strand break repair [Source:SGD;Acc:S000001015]	cellular response to amino acid starvation, meiosis, regulation of TOR signaling cascade	cellular_component	molecular_function		
YHL024W	RIM4	Putative RNA-binding protein required for the expression of early and middle sporulation genes [Source:SGD;Acc:S000001016]	meiosis, premeiotic DNA replication, reciprocal meiotic recombination, sporulation resulting in formation of a cellular spore	cytoplasm	RNA binding, nucleic acid binding, nucleotide binding		
YHL025W	SNF6	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p [Source:SGD;Acc:S000001017]	ATP-dependent chromatin remodeling, chromatin remodeling, nucleosome mobilization, nucleotide-excision repair, positive regulation of transcription, DNA-dependent	SWI/SNF complex, nucleus			
YHL026C	YHL026C	Putative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) [Source:SGD;Acc:S000001018]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YHL027W	RIM101	Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC [Source:SGD;Acc:S000001019]	ascospore formation, barrier septum formation, cellular response to anoxia, fungal-type cell wall biogenesis, meiosis, negative regulation of transcription from RNA polymerase II promoter, response to pH	cytoplasm, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YHL028W	WSC4	ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 [Source:SGD;Acc:S000001020]	SRP-dependent cotranslational protein targeting to membrane, translocation, cellular cell wall organization, protein targeting to ER, response to heat, response to stress	endoplasmic reticulum membrane, integral to membrane, membrane, membrane fraction	transmembrane receptor activity		
YHL029C	OCA5	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts [Source:SGD;Acc:S000001021]	biological_process, regulation of Rab GTPase activity	cytoplasm, intracellular	Rab GTPase activator activity, molecular_function		
YHL030W	ECM29	Scaffold protein that assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats [Source:SGD;Acc:S000001022]	proteasome assembly	cytoplasm, nucleus, proteasome complex	binding, protein complex scaffold		
YHL030W-A	YHL030W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene GOS1/YHL031C [Source:SGD;Acc:S000028773]					
YHL031C	GOS1	v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 [Source:SGD;Acc:S000001023]	ER to Golgi vesicle-mediated transport, Golgi vesicle transport, protein transport, transport, vesicle fusion	Golgi apparatus, Golgi medial cisterna, Golgi membrane, SNARE complex, cis-Golgi network, integral to membrane, membrane	SNAP receptor activity		
YHL032C	GUT1	Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p [Source:SGD;Acc:S000001024]	carbohydrate metabolic process, glycerol metabolic process, glycerol-3-phosphate metabolic process	cytoplasm, mitochondrion	ATP binding, glycerol kinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YHL033C	RPL8A	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits [Source:SGD;Acc:S000001025]	ribosome biogenesis, translation	cytoplasm, cytosolic large ribosomal subunit, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YHL034C	SBP1	Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 [Source:SGD;Acc:S000001026]	negative regulation of translation in response to stress, response to stress	cytoplasm, cytoplasmic mRNA processing body, nucleolus, nucleus	RNA binding, nucleic acid binding, nucleotide binding		
YHL034W-A	YHL034W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028774]					
YHL035C	VMR1	Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions [Source:SGD;Acc:S000001027]	auxin biosynthetic process, drug transport, response to drug, response to metal ion, transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, mitochondrion, ribosome, vacuolar membrane, vacuole	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YHL036W	MUP3	Low affinity methionine permease, similar to Mup1p [Source:SGD;Acc:S000001028]	amino acid transport, transmembrane transport, transport	integral to membrane, membrane	L-methionine transmembrane transporter activity, amino acid transmembrane transporter activity		
YHL037C	YHL037C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001029]					
YHL038C	CBP2	Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene [Source:SGD;Acc:S000001030]	Group I intron splicing, RNA splicing, mRNA processing	mitochondrion	RNA binding		
YHL039W	EFM1	Probable lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001031]	peptidyl-lysine monomethylation	cytoplasm	methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity		
YHL040C	ARN1	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores [Source:SGD;Acc:S000001032]	ion transport, iron ion transport, siderophore transport, transport	cytoplasmic membrane-bounded vesicle, endosome, endosome membrane, integral to membrane, membrane, plasma membrane	siderophore transmembrane transporter activity		
YHL041W	YHL041W	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000001033]					
YHL042W	YHL042W	Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000001034]	biological_process	cellular_component	molecular_function		
YHL043W	ECM34	Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000001035]	cellular cell wall organization, fungal-type cell wall organization	cellular_component, integral to membrane, membrane	molecular_function		
YHL044W	YHL044W	Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern [Source:SGD;Acc:S000001036]	biological_process	integral to membrane, membrane, plasma membrane	molecular_function		
YHL045W	YHL045W	Putative protein of unknown function; not an essential gene [Source:SGD;Acc:S000001037]					
YHL046C	PAU13	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock [Source:SGD;Acc:S000001038]	biological_process, response to stress	cellular_component	molecular_function		
YHL046W-A	YHL046W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028775]					
YHL047C	ARN2	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C [Source:SGD;Acc:S000001039]	cellular iron ion homeostasis, ion transport, iron ion transport, siderophore metabolic process, siderophore transport, transmembrane transport, transport	cytoplasmic membrane-bounded vesicle, endosome, endosome membrane, integral to membrane, membrane, plasma membrane	siderophore transmembrane transporter activity		
YHL048C-A	YHL048C-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028829]	biological_process	cellular_component	molecular_function		
YHL048W	COS8	Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response [Source:SGD;Acc:S000001040]	biological_process	integral to membrane, membrane, nuclear envelope	molecular_function		
YHL049C	YHL049C	Putative protein of unknown function [Source:SGD;Acc:S000001041]	biological_process	cellular_component	molecular_function		
YHL050C	YHL050C	Putative protein of unknown function, potential Cdc28p substrate [Source:SGD;Acc:S000001042]	biological_process	cellular_component, integral to membrane, membrane	ATP binding, ATP-dependent helicase activity, helicase activity, nucleic acid binding		
YHL050W-A	YHL050W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028644]					
YHR001W	OSH7	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability [Source:SGD;Acc:S000001043]	endocytosis, exocytosis, late endosome to vacuole transport, lipid transport, maintenance of cell polarity, steroid metabolic process, sterol metabolic process, sterol transport, transport	cortical endoplasmic reticulum, cytoplasm, soluble fraction	lipid binding, oxysterol binding		
YHR001W-A	QCR10	Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain [Source:SGD;Acc:S000003529]	aerobic respiration, electron transport chain, mitochondrial electron transport, ubiquinol to cytochrome c, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex III, mitochondrion, respiratory chain	ubiquinol-cytochrome-c reductase activity		
YHR002W	LEU5	Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized [Source:SGD;Acc:S000001044]	coenzyme A transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, coenzyme A transmembrane transporter activity		
YHR003C	YHR003C	Protein of unknown function, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000001045]	biological_process, metabolic process	mitochondrial outer membrane, mitochondrion	binding, catalytic activity, molecular_function		
YHR004C	NEM1	Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard [Source:SGD;Acc:S000001046]	ascospore formation, nuclear envelope organization, regulation of lipid biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion, nuclear membrane, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding		
YHR005C	GPA1	GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome [Source:SGD;Acc:S000001047]	G-protein coupled receptor protein signaling pathway, adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, heterotrimeric G-protein complex cycle, inositol lipid-mediated signaling, karyogamy involved in conjugation with cellular fusion, nuclear migration involved in conjugation with cellular fusion, pheromone-dependent signal transduction involved in conjugation with cellular fusion, regulation of MAPK export from nucleus, response to pheromone, signal transduction	endosome, endosome membrane, heterotrimeric G-protein complex, membrane, plasma membrane	GTP binding, GTPase activity, guanyl nucleotide binding, nucleotide binding, signal transducer activity		
YHR005C-A	TIM10	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane [Source:SGD;Acc:S000003530]	protein import into mitochondrial inner membrane, protein targeting to mitochondrion, protein transport, transmembrane transport, transport	membrane, mitochondrial inner membrane, mitochondrial inner membrane protein insertion complex, mitochondrial intermembrane space protein transporter complex, mitochondrion	metal ion binding, protein transporter activity, unfolded protein binding		
YHR006W	STP2	Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes [Source:SGD;Acc:S000001048]	positive regulation of transcription from RNA polymerase II promoter	intracellular, membrane, nucleus, plasma membrane	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YHR007C	ERG11	Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family [Source:SGD;Acc:S000001049]	ergosterol biosynthetic process, lipid biosynthetic process, oxidation-reduction process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, integral to membrane, membrane	electron carrier activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, sterol 14-demethylase activity		
YHR007C-A	YHR007C-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028830]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YHR008C	SOD2	Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated [Source:SGD;Acc:S000001050]	age-dependent response to oxidative stress involved in chronological cell aging, age-dependent response to reactive oxygen species involved in chronological cell aging, oxidation-reduction process, replicative cell aging, superoxide metabolic process	mitochondrial matrix, mitochondrion	metal ion binding, oxidoreductase activity, superoxide dismutase activity		
YHR009C	YHR009C	Putative protein of unknown function; not an essential gene [Source:SGD;Acc:S000001051]	biological_process	cytoplasm, integral to membrane, membrane	molecular_function, oxidoreductase activity		
YHR010W	RPL27A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein [Source:SGD;Acc:S000001052]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YHR011W	DIA4	Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth [Source:SGD;Acc:S000001053]	invasive growth in response to glucose limitation, mitochondrial seryl-tRNA aminoacylation, pseudohyphal growth, seryl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, serine-tRNA ligase activity		
YHR012W	VPS29	Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval [Source:SGD;Acc:S000001054]	protein transport, retrograde transport, endosome to Golgi, transport	endosome, retromer complex, retromer complex, inner shell	hydrolase activity, acting on ester bonds, protein transporter activity		
YHR013C	ARD1	Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells [Source:SGD;Acc:S000001055]	N-terminal protein amino acid acetylation, histone acetylation, metabolic process	NatA complex, cytoplasm, cytosolic ribosome	N-acetyltransferase activity, acyltransferase activity, peptide alpha-N-acetyltransferase activity, transferase activity		
YHR014W	SPO13	Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II [Source:SGD;Acc:S000001056]	meiosis, meiotic sister chromatid cohesion, positive regulation of sister chromatid cohesion, protein localization to chromosome, centromeric region, sporulation resulting in formation of a cellular spore	condensed nuclear chromosome, centromeric region, nucleus	molecular_function		
YHR015W	MIP6	Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export [Source:SGD;Acc:S000001057]	mRNA export from nucleus	cytoplasm, nuclear pore	RNA binding, nucleic acid binding, nucleotide binding		
YHR016C	YSC84	Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p [Source:SGD;Acc:S000001058]	actin cortical patch localization, actin cytoskeleton organization, actin filament bundle assembly, actin filament organization, endocytosis	actin cortical patch, cytoplasm, cytoskeleton	actin filament binding, protein binding		
YHR017W	YSC83	Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 [Source:SGD;Acc:S000001059]	biological_process	membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YHR018C	ARG4	Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway [Source:SGD;Acc:S000001060]	arginine biosynthetic process, arginine biosynthetic process via ornithine, cellular amino acid biosynthetic process	cytosol	argininosuccinate lyase activity, catalytic activity, lyase activity		
YHR019C	DED81	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA [Source:SGD;Acc:S000001061]	asparaginyl-tRNA aminoacylation, aspartyl-tRNA aminoacylation, auxin biosynthetic process, tRNA aminoacylation for protein translation, translation	cytoplasm	ATP binding, aminoacyl-tRNA ligase activity, asparagine-tRNA ligase activity, aspartate-tRNA ligase activity, ligase activity, nucleic acid binding, nucleotide binding		
YHR020W	YHR020W	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene [Source:SGD;Acc:S000001062]	chromosome organization, prolyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, ribosome	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, proline-tRNA ligase activity		
YHR021C	RPS27B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein [Source:SGD;Acc:S000001063]	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit assembly, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	metal ion binding, structural constituent of ribosome		
YHR021W-A	ECM12	Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity [Source:SGD;Acc:S000003531]	cellular cell wall organization, fungal-type cell wall organization	cellular_component, integral to membrane, membrane	molecular_function		
YHR022C	YHR022C	Putative protein of unknown function; YHR022C is not an essential gene [Source:SGD;Acc:S000001064]	biological_process, small GTPase mediated signal transduction	cellular_component	ATP binding, GTP binding, molecular_function, nucleotide binding		
YHR022C-A	YHR022C-A	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028645]	biological_process	cellular_component	molecular_function		
YHR023W	MYO1	Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively [Source:SGD;Acc:S000001065]	contractile ring contraction involved in cell cycle cytokinesis, cytokinesis, cytokinesis, actomyosin contractile ring assembly, cytokinesis, completion of separation	cellular bud neck, cellular bud neck contractile ring, incipient cellular bud site, myosin II complex, myosin complex	ATP binding, actin binding, microfilament motor activity, motor activity, nucleotide binding, protein binding		
YHR024C	MAS2	Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins [Source:SGD;Acc:S000001066]	protein processing involved in protein targeting to mitochondrion, proteolysis	mitochondrial matrix, mitochondrial processing peptidase complex, mitochondrion	catalytic activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding		
YHR025W	THR1	Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway [Source:SGD;Acc:S000001067]	auxin biosynthetic process, cellular amino acid biosynthetic process, homoserine metabolic process, isoleucine metabolic process, methionine metabolic process, phosphorylation, threonine biosynthetic process, threonine metabolic process	cellular_component	ATP binding, homoserine kinase activity, kinase activity, nucleotide binding, transferase activity		
YHR026W	VMA16	Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain [Source:SGD;Acc:S000001068]	ATP hydrolysis coupled proton transport, ATP synthesis coupled proton transport, ion transport, proton transport, transport, vacuolar acidification	integral to membrane, membrane, proton-transporting V-type ATPase, V0 domain, proton-transporting two-sector ATPase complex, proton-transporting domain, vacuolar proton-transporting V-type ATPase, V0 domain	hydrogen ion transmembrane transporter activity, hydrolase activity, proton-transporting ATPase activity, rotational mechanism		
YHR027C	RPN1	Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions [Source:SGD;Acc:S000001069]	regulation of protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, endoplasmic reticulum, nucleus, proteasome complex, proteasome regulatory particle, base subcomplex, proteasome storage granule	binding, endopeptidase activity, enzyme regulator activity, protein binding, bridging		
YHR028C	DAP2	Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p [Source:SGD;Acc:S000001070]	protein processing, proteolysis	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	aminopeptidase activity, dipeptidyl-peptidase activity, hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity		
YHR028W-A	YHR028W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028776]					
YHR029C	YHI9	Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production [Source:SGD;Acc:S000001071]	biosynthetic process, endoplasmic reticulum unfolded protein response	cellular_component	catalytic activity, isomerase activity, molecular_function		
YHR030C	SLT2	Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; regulated by the PKC1-mediated signaling pathway [Source:SGD;Acc:S000001072]	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response, auxin biosynthetic process, barrier septum formation, endoplasmic reticulum unfolded protein response, fungal-type cell wall organization, peroxisome degradation, protein phosphorylation, regulation of cell size, regulation of transcription factor import into nucleus, response to acid, signal transduction	cellular bud tip, cytoplasm, nucleus	ATP binding, MAP kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YHR031C	RRM3	DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p [Source:SGD;Acc:S000001073]	DNA replication, auxin biosynthetic process, mitochondrial genome maintenance	nuclear telomeric heterochromatin, replication fork	ATP binding, ATP-dependent DNA helicase activity, DNA helicase activity, helicase activity, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding		
YHR032C-A	YHR032C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032W-A [Source:SGD;Acc:S000028646]					
YHR032W	ERC1	Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine [Source:SGD;Acc:S000001074]	S-adenosylmethionine biosynthetic process, drug transmembrane transport, transmembrane transport, transport	cellular_component, integral to membrane, membrane	antiporter activity, drug transmembrane transporter activity		
YHR032W-A	YHR032W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A [Source:SGD;Acc:S000028831]					
YHR033W	YHR033W	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm [Source:SGD;Acc:S000001075]	biological_process, cellular amino acid biosynthetic process, proline biosynthetic process	cytoplasm	RNA binding, glutamate 5-kinase activity, kinase activity, molecular_function, transferase activity		
YHR034C	PIH1	Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p) [Source:SGD;Acc:S000001076]	RNA splicing, mRNA processing, protein folding, rRNA processing, regulation of cell size	cytoplasm, nucleus, small nucleolar ribonucleoprotein complex	molecular_function		
YHR035W	YHR035W	Putative protein of unknown function; not an essential gene [Source:SGD;Acc:S000001077]	ER to Golgi vesicle-mediated transport, biological_process, intracellular protein transport	COPII vesicle coat, cellular_component	molecular_function, zinc ion binding		
YHR036W	BRL1	Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export [Source:SGD;Acc:S000001078]	mRNA export from nucleus, mRNA transport, nuclear envelope organization, protein export from nucleus, protein transport, transport	endoplasmic reticulum, integral to membrane, membrane, nuclear envelope, nuclear membrane, nucleus	molecular_function		
YHR037W	PUT2	Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism [Source:SGD;Acc:S000001079]	glutamate biosynthetic process, metabolic process, oxidation-reduction process, proline biosynthetic process, proline catabolic process to glutamate, proline metabolic process	membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion	1-pyrroline-5-carboxylate dehydrogenase activity, oxidoreductase activity		
YHR038W	RRF1	Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria [Source:SGD;Acc:S000001080]	mitochondrial translation, translation	mitochondrion	translation release factor activity		
YHR039C	MSC7	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids [Source:SGD;Acc:S000001081]	metabolic process, oxidation-reduction process, reciprocal meiotic recombination	endoplasmic reticulum	molecular_function, oxidoreductase activity		
YHR039C-A	VMA10	Subunit G of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification [Source:SGD;Acc:S000002100]	ion transport, proton transport, transport, vacuolar acidification	vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain	hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, proton-transporting ATPase activity, rotational mechanism		
YHR040W	BCD1	Essential protein required for the accumulation of box C/D snoRNA [Source:SGD;Acc:S000001082]	ribosome biogenesis, snoRNA metabolic process	cytoplasm, nucleus	metal ion binding, nucleic acid binding		
YHR041C	SRB2	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance [Source:SGD;Acc:S000001083]	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus, negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus			
YHR042W	NCP1	NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p [Source:SGD;Acc:S000001084]	ergosterol biosynthetic process, oxidation-reduction process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome, mitochondrial outer membrane, mitochondrion	FMN binding, NADPH-hemoprotein reductase activity, electron carrier activity, iron ion binding, oxidoreductase activity		
YHR043C	DOG2	2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed [Source:SGD;Acc:S000001085]	ER-associated protein catabolic process, glucose metabolic process, metabolic process	cytoplasm, nucleus	2-deoxyglucose-6-phosphatase activity, catalytic activity, hydrolase activity		
YHR044C	DOG1	2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified [Source:SGD;Acc:S000001086]	glucose metabolic process, metabolic process	cellular_component	2-deoxyglucose-6-phosphatase activity, catalytic activity, hydrolase activity		
YHR045W	YHR045W	Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum [Source:SGD;Acc:S000001087]	biological_process	endoplasmic reticulum, integral to membrane, membrane	molecular_function		
YHR046C	INM1	Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate [Source:SGD;Acc:S000001088]	inositol phosphate dephosphorylation	cytoplasm, nucleus	hydrolase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1(or 4)-monophosphatase activity, metal ion binding		
YHR047C	AAP1	Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation [Source:SGD;Acc:S000001089]	glycogen metabolic process, proteolysis	cytoplasm, nucleus	aminopeptidase activity, hydrolase activity, metal ion binding, metallopeptidase activity, peptidase activity, zinc ion binding		
YHR048W	YHK8	Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles [Source:SGD;Acc:S000001090]	drug transport, transmembrane transport, transport	integral to membrane, membrane	molecular_function, transporter activity		
YHR049C-A	YHR049C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003532]					
YHR049W	FSH1	Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2 [Source:SGD;Acc:S000001091]	biological_process	cytoplasm, nucleus	carboxylesterase activity, hydrolase activity		
YHR050W	SMF2	Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins [Source:SGD;Acc:S000001092]	cellular cobalt ion homeostasis, cellular manganese ion homeostasis, cobalt ion transport, manganese ion transport, transport	cytoplasmic membrane-bounded vesicle, integral to membrane, membrane, mitochondrion, vacuolar membrane, vacuole	inorganic cation transmembrane transporter activity, metal ion binding, transporter activity		
YHR050W-A	YHR050W-A	Protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028832]	biological_process	cellular_component	molecular_function		
YHR051W	COX6	Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels [Source:SGD;Acc:S000001093]	mitochondrial electron transport, cytochrome c to oxygen, oxidation-reduction process	membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion	cytochrome-c oxidase activity, metal ion binding, oxidoreductase activity		
YHR052W	CIC1	Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles [Source:SGD;Acc:S000001094]	RNA processing, protein catabolic process, ribosomal large subunit biogenesis, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor, proteasome complex	RNA binding, protein binding, bridging		
YHR052W-A	YHR052W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1 [Source:SGD;Acc:S000028647]					
YHR053C	CUP1-1	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C [Source:SGD;Acc:S000001095]	detoxification of cadmium ion, detoxification of copper ion, removal of superoxide radicals, response to copper ion	cytosol	antioxidant activity, cadmium ion binding, copper ion binding, metal ion binding, superoxide dismutase activity		
YHR054C	YHR054C	Putative protein of unknown function [Source:SGD;Acc:S000001096]	biological_process	cellular_component	molecular_function		
YHR054W-A	YHR054W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2 [Source:SGD;Acc:S000028648]					
YHR055C	CUP1-2	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C [Source:SGD;Acc:S000001097]	detoxification of cadmium ion, detoxification of copper ion, removal of superoxide radicals, response to copper ion	cytosol	antioxidant activity, cadmium ion binding, copper ion binding, metal ion binding, superoxide dismutase activity		
YHR056C	RSC30	Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive [Source:SGD;Acc:S000001098]	ATP-dependent chromatin remodeling, chromatin modification, double-strand break repair via nonhomologous end joining, nucleosome disassembly, regulation of transcription, DNA-dependent, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus, ribosome	DNA binding, DNA-dependent ATPase activity, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YHR056W-A	YHR056W-A	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028777]					
YHR057C	CPR2	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway [Source:SGD;Acc:S000001099]	biological_process, protein folding	cellular_component, extracellular region	isomerase activity, peptide binding, peptidyl-prolyl cis-trans isomerase activity		
YHR058C	MED6	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000001100]	regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus			
YHR059W	FYV4	Protein of unknown function, required for survival upon exposure to K1 killer toxin [Source:SGD;Acc:S000001101]	biological_process	mitochondrion	molecular_function		
YHR060W	VMA22	Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) [Source:SGD;Acc:S000001102]	vacuolar acidification, vacuolar proton-transporting V-type ATPase complex assembly	extrinsic to endoplasmic reticulum membrane	unfolded protein binding		
YHR061C	GIC1	Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain [Source:SGD;Acc:S000001103]	Rho protein signal transduction, axial cellular bud site selection, establishment of cell polarity, regulation of cell shape, regulation of exit from mitosis	actin cap, cell cortex, cellular bud neck, cellular bud tip, cytoplasm, cytoskeleton, incipient cellular bud site, mating projection tip	Rho GTPase activator activity, Rho GTPase binding, protein binding		
YHR062C	RPP1	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends [Source:SGD;Acc:S000001104]	intronic box C/D snoRNA processing, mRNA cleavage, rRNA processing, tRNA processing	nucleolar ribonuclease P complex, nucleus, ribonuclease MRP complex	catalytic activity, hydrolase activity, ribonuclease MRP activity, ribonuclease P activity, ribonuclease activity		
YHR063C	PAN5	2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE [Source:SGD;Acc:S000001105]	metabolic process, oxidation-reduction process, pantothenate biosynthetic process	cytoplasm, soluble fraction	2-dehydropantoate 2-reductase activity, NADP binding, binding, catalytic activity, coenzyme binding, oxidoreductase activity		
YHR063W-A	YHR063W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028778]					
YHR064C	SSZ1	Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP [Source:SGD;Acc:S000001106]	auxin biosynthetic process, rRNA processing, regulation of translational fidelity, translation	cytoplasm	ATP binding, nucleotide binding, unfolded protein binding		
YHR065C	RRP3	Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity [Source:SGD;Acc:S000001107]	auxin biosynthetic process, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, RNA-dependent ATPase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YHR066W	SSF1	Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family [Source:SGD;Acc:S000001108]	conjugation with cellular fusion, regulation of cell size, ribosomal large subunit assembly, ribosome biogenesis	nucleolus, nucleus	rRNA binding		
YHR067W	HTD2	Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology [Source:SGD;Acc:S000001109]	fatty acid biosynthetic process, oxidation-reduction process	mitochondrion	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity, lyase activity, oxidoreductase activity		
YHR068W	DYS1	Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric [Source:SGD;Acc:S000001110]	peptidyl-lysine modification to hypusine, spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase	cytoplasm	deoxyhypusine synthase activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups		
YHR069C	RRP4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) [Source:SGD;Acc:S000001111]	U4 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nonfunctional rRNA decay, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, polyadenylation-dependent snoRNA 3'-end processing, rRNA processing	cytoplasm, cytoplasmic exosome (RNase complex), exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleus	RNA binding, hydrolase activity, molecular_function		
YHR069C-A	YHR069C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028779]					
YHR070C-A	YHR070C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W [Source:SGD;Acc:S000028780]					
YHR070W	TRM5	tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya [Source:SGD;Acc:S000001112]	tRNA methylation, tRNA processing	cytoplasm, mitochondrial matrix, nucleus	methyltransferase activity, tRNA (guanine) methyltransferase activity, tRNA (guanine-N1-)-methyltransferase activity, transferase activity		
YHR071C-A	YHR071C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W [Source:SGD;Acc:S000028781]					
YHR071W	PCL5	Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity [Source:SGD;Acc:S000001113]	cell cycle, cell division, negative regulation of macroautophagy, negative regulation of sequence-specific DNA binding transcription factor activity, regulation of protein stability	cyclin-dependent protein kinase holoenzyme complex, nucleus	cyclin-dependent protein kinase regulator activity		
YHR072W	ERG7	Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis [Source:SGD;Acc:S000001114]	ergosterol biosynthetic process, lipid biosynthetic process, steroid biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, lipid particle, membrane, plasma membrane	catalytic activity, intramolecular transferase activity, isomerase activity, lanosterol synthase activity		
YHR072W-A	NOP10	Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA [Source:SGD;Acc:S000007455]	cleavage involved in rRNA processing, rRNA processing, rRNA pseudouridine synthesis, ribosome biogenesis, snRNA pseudouridine synthesis	box H/ACA snoRNP complex, nucleolus, nucleus, ribonucleoprotein complex	RNA binding, nucleic acid binding		
YHR073C-B	YHR073C-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028833]					
YHR073W	OSH3	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability [Source:SGD;Acc:S000001115]	endocytosis, exocytosis, invasive growth in response to glucose limitation, karyogamy involved in conjugation with cellular fusion, lipid transport, maintenance of cell polarity, pseudohyphal growth, steroid metabolic process, sterol transport, transport	cortical endoplasmic reticulum, cytoplasm	1-phosphatidylinositol binding, lipid binding, oxysterol binding, protein binding, sterol transporter activity		
YHR073W-A	YHR073W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028834]					
YHR074W	QNS1	Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide [Source:SGD;Acc:S000001116]	NAD biosynthetic process, nitrogen compound metabolic process	cytoplasm, nucleus	ATP binding, NAD+ synthase (glutamine-hydrolyzing) activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, ligase activity, nucleotide binding		
YHR075C	PPE1	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein [Source:SGD;Acc:S000001117]	protein modification process	soluble fraction	carboxylesterase activity, hydrolase activity		
YHR076W	PTC7	Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope [Source:SGD;Acc:S000001118]	biological_process	mitochondrion, nuclear envelope	catalytic activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YHR077C	NMD2	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance [Source:SGD;Acc:S000001119]	RNA metabolic process, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm, polysome	binding, protein binding		
YHR078W	YHR078W	High osmolarity-regulated gene of unknown function [Source:SGD;Acc:S000001120]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YHR079C	IRE1	Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress [Source:SGD;Acc:S000001121]	endoplasmic reticulum unfolded protein response, fungal-type cell wall organization, inositol metabolic process, mRNA processing, protein phosphorylation, response to unfolded protein	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nucleus	ATP binding, catalytic activity, endoribonuclease activity, endoribonuclease activity, producing 5'-phosphomonoesters, hydrolase activity, kinase activity, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, transferase activity, unfolded protein binding		
YHR079C-A	SAE3	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p [Source:SGD;Acc:S000001957]	DNA repair, double-strand break repair, meiosis, meiotic DNA recombinase assembly, reciprocal meiotic recombination, response to DNA damage stimulus	condensed nuclear chromosome, nucleus	molecular_function		
YHR080C	YHR080C	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001122]	biological_process	integral to membrane, membrane, mitochondrion, ribosome	molecular_function		
YHR081W	LRP1	Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination [Source:SGD;Acc:S000001123]	U4 snRNA 3'-end processing, U5 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nuclear mRNA surveillance, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear retention of pre-mRNA at the site of transcription, polyadenylation-dependent snoRNA 3'-end processing, posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery, rRNA processing	exosome (RNase complex), nuclear exosome (RNase complex), nucleus	RNA binding, double-stranded DNA binding, double-stranded RNA binding		
YHR082C	KSP1	Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10 [Source:SGD;Acc:S000001124]	filamentous growth, protein phosphorylation	nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YHR083W	SAM35	Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane [Source:SGD;Acc:S000001125]	mitochondrial outer membrane translocase complex assembly, protein import into mitochondrial outer membrane, protein transport, transport	membrane, mitochondrial outer membrane, mitochondrial sorting and assembly machinery complex, mitochondrion	molecular_function		
YHR084W	STE12	Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth [Source:SGD;Acc:S000001126]	conjugation with cellular fusion, invasive growth in response to glucose limitation, positive regulation of transcription from RNA polymerase II promoter by pheromones, pseudohyphal growth, regulation of transcription, DNA-dependent, response to pheromone	nucleoplasm, nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YHR085W	IPI1	Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles [Source:SGD;Acc:S000001127]	rRNA processing, ribosomal large subunit assembly, ribosome biogenesis	nucleoplasm, nucleus	binding, molecular_function		
YHR086W	NAM8	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA [Source:SGD;Acc:S000001128]	mRNA processing, mRNA splice site selection, nuclear mRNA splicing, via spliceosome, positive regulation of nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, commitment complex, mitochondrion	RNA binding, mRNA binding, nucleic acid binding, nucleotide binding		
YHR086W-A	YHR086W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028552]	biological_process	cellular_component	molecular_function		
YHR087W	RTC3	Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity [Source:SGD;Acc:S000001129]	RNA metabolic process	cytoplasm, nucleus	molecular_function		
YHR088W	RPF1	Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA [Source:SGD;Acc:S000001130]	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal large subunit assembly, ribosomal large subunit export from nucleus, ribosome biogenesis, translation	nucleolus, nucleus, preribosome, large subunit precursor	ATP binding, RNA binding, aminoacyl-tRNA ligase activity, rRNA binding, rRNA primary transcript binding		
YHR089C	GAR1	Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA [Source:SGD;Acc:S000001131]	rRNA processing, ribosome biogenesis, snRNA pseudouridine synthesis	box H/ACA snoRNP complex, nucleolus, nucleus, ribonucleoprotein complex, small nucleolar ribonucleoprotein complex	RNA binding, box H/ACA snoRNA binding, pseudouridine synthase activity, snoRNA binding		
YHR090C	YNG2	Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1 and its isoforms ING4 and ING5 [Source:SGD;Acc:S000001132]	DNA repair, cell cycle, chromatin modification, histone acetylation, meiosis, response to DNA damage stimulus	NuA4 histone acetyltransferase complex, Piccolo NuA4 histone acetyltransferase complex, nucleus	histone acetyltransferase activity, metal ion binding, methylated histone residue binding, protein binding, transferase activity, zinc ion binding		
YHR091C	MSR1	Mitochondrial arginyl-tRNA synthetase [Source:SGD;Acc:S000001133]	arginyl-tRNA aminoacylation, auxin biosynthetic process, mitochondrial arginyl-tRNA aminoacylation, mitochondrial translation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, arginine-tRNA ligase activity, ligase activity, nucleotide binding		
YHR092C	HXT4	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose [Source:SGD;Acc:S000001134]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, plasma membrane	fructose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, pentose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YHR093W	AHT1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region [Source:SGD;Acc:S000001135]					
YHR094C	HXT1	Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting [Source:SGD;Acc:S000001136]	carbohydrate transport, glucose transport, mannose transport, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, plasma membrane	fructose transmembrane transporter activity, galactose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, pentose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YHR095W	YHR095W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001137]					
YHR096C	HXT5	Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs [Source:SGD;Acc:S000001138]	carbohydrate transport, glucose transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, plasma membrane, plasma membrane enriched fraction	fructose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YHR097C	YHR097C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus [Source:SGD;Acc:S000001139]	biological_process	cytoplasm, nucleus	molecular_function		
YHR098C	SFB3	Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p [Source:SGD;Acc:S000001140]	ER to Golgi vesicle-mediated transport, cargo loading into COPII-coated vesicle, intracellular protein transport, protein transport, transport, vesicle-mediated transport	COPII vesicle coat, Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, mating projection tip, membrane	signal sequence binding, zinc ion binding		
YHR099W	TRA1	Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation [Source:SGD;Acc:S000001141]	DNA repair, chromatin modification, histone acetylation, positive regulation of transcription from RNA polymerase II promoter	ASTRA complex, NuA4 histone acetyltransferase complex, SAGA complex, SLIK (SAGA-like) complex, histone acetyltransferase complex, nucleus	binding, histone acetyltransferase activity, phosphotransferase activity, alcohol group as acceptor, protein binding		
YHR100C	GEP4	Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT [Source:SGD;Acc:S000001142]	cardiolipin biosynthetic process, phospholipid biosynthetic process, phosphorylated carbohydrate dephosphorylation	membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion	hydrolase activity, phosphatidylglycerophosphatase activity		
YHR101C	BIG1	Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan [Source:SGD;Acc:S000001143]	cellular cell wall organization, fungal-type cell wall biogenesis	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YHR102W	KIC1	Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body [Source:SGD;Acc:S000001144]	auxin biosynthetic process, budding cell apical bud growth, cell morphogenesis, fungal-type cell wall organization, protein phosphorylation	cellular bud, cytoplasm, incipient cellular bud site, mating projection tip	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YHR103W	SBE22	Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth [Source:SGD;Acc:S000001145]	cellular cell wall organization, fungal-type cell wall organization, protein transport, transport	Golgi apparatus, cytoplasm	molecular_function		
YHR104W	GRE3	Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway [Source:SGD;Acc:S000001146]	D-xylose catabolic process, arabinose catabolic process, cellular response to oxidative stress, galactose catabolic process, oxidation-reduction process, response to stress	cytoplasm, nucleus	alditol:NADP+ 1-oxidoreductase activity, glucose 1-dehydrogenase (NADP+) activity, oxidoreductase activity		
YHR105W	YPT35	Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport [Source:SGD;Acc:S000001147]	biological_process, cell communication	endosome, endosome membrane, membrane	phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding		
YHR106W	TRR2	Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD [Source:SGD;Acc:S000001148]	cell redox homeostasis, cellular response to oxidative stress, oxidation-reduction process, removal of superoxide radicals	cytoplasm, mitochondrion	flavin adenine dinucleotide binding, oxidoreductase activity, thioredoxin-disulfide reductase activity		
YHR107C	CDC12	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM [Source:SGD;Acc:S000001149]	axial cellular bud site selection, bipolar cellular bud site selection, cell cycle, cell division, cell morphogenesis, conjugation with cellular fusion, cytokinesis, establishment of cell polarity, fungal-type cell wall organization	cellular bud neck, cellular bud neck septin ring, cytoplasm, mating projection, membrane, septin complex	1-phosphatidylinositol binding, GTP binding, GTPase activity, nucleotide binding, structural constituent of cytoskeleton		
YHR108W	GGA2	Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin [Source:SGD;Acc:S000001150]	Golgi to endosome transport, Golgi to vacuole transport, intracellular protein transport, protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, protein transport, transport, vesicle-mediated transport	Golgi apparatus, Golgi apparatus part, clathrin adaptor complex, intracellular, membrane coat, trans-Golgi network	phosphatidylinositol-4-phosphate binding, ubiquitin binding		
YHR109W	CTM1	Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth [Source:SGD;Acc:S000001151]	peptidyl-lysine methylation	cytoplasm, cytosol	[cytochrome c]-lysine N-methyltransferase activity, methyltransferase activity, transferase activity		
YHR110W	ERP5	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport [Source:SGD;Acc:S000001152]	protein transport, transport, vesicle-mediated transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YHR111W	UBA4	Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p [Source:SGD;Acc:S000001153]	cell budding, cellular response to oxidative stress, invasive growth in response to glucose limitation, metabolic process, protein modification process, pseudohyphal growth, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification	cytoplasm	ATP binding, URM1 activating enzyme activity, binding, catalytic activity, metal ion binding, nucleotide binding, peroxidase activity, protein adenylyltransferase activity, sulfurtransferase activity, thiosulfate sulfurtransferase activity, transferase activity		
YHR112C	YHR112C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001154]	cellular amino acid metabolic process, sulfur compound metabolic process	cytoplasm	catalytic activity, cystathionine beta-lyase activity, lyase activity, pyridoxal phosphate binding		
YHR113W	YHR113W	Cytoplasmic aspartyl aminopeptidase; cleaves unblocked N-terminal acidic amino acid residues from peptide substrates; forms a 12 subunit homo-oligomeric complex; M18 metalloprotease family member; may interact with ribosomes [Source:SGD;Acc:S000001155]	proteolysis	cytoplasm, ribosome, vacuole	aminopeptidase activity, hydrolase activity, metal ion binding, metallopeptidase activity, peptidase activity, zinc ion binding		
YHR114W	BZZ1	SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins [Source:SGD;Acc:S000001156]	actin filament organization, endocytosis, response to salt stress	actin cortical patch, cytoplasm, mating projection tip	molecular_function, protein binding		
YHR115C	DMA1	Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr. [Source:SGD;Acc:S000001157]	cell cycle, cell division, establishment of mitotic spindle orientation, mitosis, mitotic cell cycle spindle assembly checkpoint, protein autoubiquitination, septin ring assembly	cytoplasm	ligase activity, metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YHR116W	COX23	Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000001158]	mitochondrial respiratory chain complex assembly	cytoplasm, mitochondrial intermembrane space, mitochondrion	molecular_function		
YHR117W	TOM71	Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins [Source:SGD;Acc:S000001159]	biological_process	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion	binding, protein binding, protein transporter activity		
YHR118C	ORC6	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p [Source:SGD;Acc:S000001160]	DNA replication, DNA-dependent DNA replication initiation, chromatin silencing at silent mating-type cassette, pre-replicative complex assembly	DNA replication preinitiation complex, nuclear origin of replication recognition complex, nucleus, pre-replicative complex	DNA binding, DNA replication origin binding		
YHR119W	SET1	Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain [Source:SGD;Acc:S000001161]	ascospore formation, chromatin modification, chromatin silencing at rDNA, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, histone H3-K4 methylation, peptidyl-lysine dimethylation, positive regulation of histone acetylation, regulation of transcription from RNA polymerase II promoter in response to stress, telomere maintenance	Set1C/COMPASS complex, chromosome, nucleus	RNA binding, histone methyltransferase activity, histone methyltransferase activity (H3-K4 specific), histone-lysine N-methyltransferase activity, methyltransferase activity, protein binding, protein-lysine N-methyltransferase activity, transferase activity		
YHR120W	MSH1	DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis [Source:SGD;Acc:S000001162]	DNA repair, mismatch repair, mitochondrial DNA repair, mitochondrial genome maintenance, mitochondrion organization, response to DNA damage stimulus	mitochondrion	ATP binding, DNA binding, DNA-dependent ATPase activity, dinucleotide insertion or deletion binding, guanine/thymine mispair binding, mismatched DNA binding, nucleotide binding		
YHR121W	LSM12	Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS [Source:SGD;Acc:S000001163]	RNA metabolic process	cytoplasm, nucleus, ribosome, stress granule	RNA binding		
YHR122W	YHR122W	Protein of unknown function required for establishment of sister chromatid cohesion; synthetically lethal with RFC5, an RF-C subunit that links replication to cohesion establishment; YHR122W is an essential gene [Source:SGD;Acc:S000001164]	chromosome segregation, establishment of mitotic sister chromatid cohesion	cytoplasm, nucleus	molecular_function		
YHR123W	EPT1	sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability [Source:SGD;Acc:S000001165]	phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process	Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome	catalytic activity, diacylglycerol cholinephosphotransferase activity, ethanolaminephosphotransferase activity, phosphotransferase activity, for other substituted phosphate groups, transferase activity		
YHR124W	NDT80	Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) [Source:SGD;Acc:S000001166]	cell cycle, cell division, meiosis	nuclear chromosome, nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YHR125W	YHR125W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001167]					
YHR126C	ANS1	Putative protein of unknown function; transcription dependent upon Azf1p [Source:SGD;Acc:S000001168]	biological_process	anchored to membrane, cell wall, cellular_component, membrane, plasma membrane	molecular_function, structural constituent of cell wall		
YHR127W	YHR127W	Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis [Source:SGD;Acc:S000001169]	mitotic spindle elongation	nucleus	molecular_function, nucleotide binding		
YHR128W	FUR1	Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway [Source:SGD;Acc:S000001170]	pyrimidine-containing compound salvage	intracellular	GTP binding, catalytic activity, nucleotide binding, transferase activity, transferase activity, transferring glycosyl groups, uracil phosphoribosyltransferase activity		
YHR129C	ARP1	Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin [Source:SGD;Acc:S000001171]	establishment of mitotic spindle orientation, nuclear migration	astral microtubule, cell cortex, cytoplasm, cytoskeleton, dynactin complex, dynein complex, membrane, microtubule, spindle pole body	motor activity, structural constituent of cytoskeleton		
YHR130C	YHR130C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001172]					
YHR131C	YHR131C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; overexpression causes a cell cycle delay or arrest [Source:SGD;Acc:S000001173]	biological_process	cytoplasm	molecular_function, protein binding		
YHR131W-A	YHR131W-A	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YHR131C [Source:SGD;Acc:S000028782]					
YHR132C	ECM14	Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly [Source:SGD;Acc:S000001174]	cellular cell wall organization, fungal-type cell wall organization, proteolysis	fungal-type vacuole, vacuole	carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding		
YHR132W-A	IGO2	Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p [Source:SGD;Acc:S000007496]	mRNA stabilization	cytoplasm, nucleus	molecular_function		
YHR133C	NSG1	Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins [Source:SGD;Acc:S000001175]	sterol biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	protein binding		
YHR134W	WSS1	Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response [Source:SGD;Acc:S000001176]	DNA repair, protein sumoylation, response to DNA damage stimulus, response to UV-B, response to UV-C	nuclear envelope, nucleus	molecular_function		
YHR135C	YCK1	Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p [Source:SGD;Acc:S000001177]	auxin biosynthetic process, cell morphogenesis, cytokinesis, endocytosis, protein phosphorylation, response to glucose stimulus	endoplasmic reticulum, membrane, mitochondrion, plasma membrane, plasma membrane enriched fraction	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YHR136C	SPL2	Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001178]	response to temperature stimulus	cytoplasm	enzyme inhibitor activity, protein kinase inhibitor activity		
YHR137C-A	YHR137C-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene ARO9/YHR137W; identified by gene-trapping, expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028649]					
YHR137W	ARO9	Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism [Source:SGD;Acc:S000001179]	aromatic amino acid family metabolic process, biosynthetic process	cytoplasm, nucleus	aromatic-amino-acid:2-oxoglutarate aminotransferase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity, transferase activity, transferring nitrogenous groups, tryptophan-phenylpyruvate transaminase activity		
YHR138C	YHR138C	Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles [Source:SGD;Acc:S000001180]	vacuole fusion, non-autophagic	cellular_component	endopeptidase inhibitor activity		
YHR139C	SPS100	Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000001181]	ascospore wall assembly, cellular amino acid metabolic process, meiosis, sporulation resulting in formation of a cellular spore	ascospore wall	molecular_function		
YHR139C-A	YHR139C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003533]					
YHR140W	YHR140W	Putative integral membrane protein of unknown function [Source:SGD;Acc:S000001182]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YHR141C	RPL42B	Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus [Source:SGD;Acc:S000001183]	response to antibiotic, response to cycloheximide, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YHR142W	CHS7	Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER [Source:SGD;Acc:S000001184]	ER to Golgi vesicle-mediated transport, cellular cell wall organization, fungal-type cell wall chitin biosynthetic process, protein folding, protein transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	unfolded protein binding		
YHR143W	DSE2	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP [Source:SGD;Acc:S000001186]	cellular cell wall organization, cytokinesis, completion of separation, pseudohyphal growth	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	glucosidase activity		
YHR143W-A	RPC10	RNA polymerase subunit ABC10-alpha, found in RNA polymerase complexes I, II, and III [Source:SGD;Acc:S000001185]	transcription from RNA polymerase I promoter, transcription from RNA polymerase II promoter, transcription from RNA polymerase III promoter	DNA-directed RNA polymerase I complex, DNA-directed RNA polymerase II, core complex, DNA-directed RNA polymerase III complex, nucleolus, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding		
YHR144C	DCD1	Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated [Source:SGD;Acc:S000001187]	nucleotide biosynthetic process, pyrimidine nucleotide biosynthetic process	cytoplasm	catalytic activity, dCMP deaminase activity, hydrolase activity, metal ion binding, zinc ion binding		
YHR145C	YHR145C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001188]					
YHR146W	CRP1	Protein that binds to cruciform DNA structures [Source:SGD;Acc:S000001189]	biological_process	nucleus	DNA binding		
YHR147C	MRPL6	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000001190]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YHR148W	IMP3	Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA [Source:SGD;Acc:S000001191]	rRNA processing, ribosome biogenesis	90S preribosome, Mpp10 complex, intracellular, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	RNA binding, rRNA binding, snoRNA binding		
YHR149C	SKG6	Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p [Source:SGD;Acc:S000001192]	biological_process	cell cortex, cellular bud neck, cellular bud tip, incipient cellular bud site, integral to membrane, membrane	molecular_function		
YHR150W	PEX28	Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p [Source:SGD;Acc:S000001193]	peroxisome organization	integral to membrane, membrane, peroxisomal membrane, peroxisome	molecular_function		
YHR151C	MTC6	Protein of unknown function; mtc6 is synthetically sick with cdc13-1 [Source:SGD;Acc:S000001194]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YHR152W	SPO12	Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis [Source:SGD;Acc:S000001195]	meiosis, meiosis I, mitotic cell cycle, regulation of exit from mitosis, sporulation resulting in formation of a cellular spore	nucleolus, nucleus	molecular_function		
YHR153C	SPO16	Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation [Source:SGD;Acc:S000001196]	ascospore formation, meiosis, regulation of reciprocal meiotic recombination, sporulation resulting in formation of a cellular spore, synaptonemal complex assembly	condensed nuclear chromosome	molecular_function		
YHR154W	RTT107	Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition [Source:SGD;Acc:S000001197]	double-strand break repair, negative regulation of transposition, RNA-mediated	Cul8-RING ubiquitin ligase complex, intracellular, nucleus	molecular_function		
YHR155W	YSP1	Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone [Source:SGD;Acc:S000001198]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function, protein binding		
YHR156C	LIN1	Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication [Source:SGD;Acc:S000001199]	biological_process	U4/U6 x U5 tri-snRNP complex, U5 snRNP, chromatin, nucleus	protein binding		
YHR157W	REC104	Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination [Source:SGD;Acc:S000001200]	meiosis, meiotic DNA double-strand break formation, reciprocal meiotic recombination	condensed nuclear chromosome	molecular_function		
YHR158C	KEL1	Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate [Source:SGD;Acc:S000001201]	cell morphogenesis, cytogamy, negative regulation of exit from mitosis, plasma membrane fusion, regulation of cell shape	cellular bud neck, cellular bud tip, cytoplasm, mating projection tip	molecular_function		
YHR159W	YHR159W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate [Source:SGD;Acc:S000001202]	biological_process	cytoplasm	molecular_function		
YHR160C	PEX18	Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p [Source:SGD;Acc:S000001203]	protein import into peroxisome matrix	cytoplasm, cytosol, membrane, peroxisomal membrane, peroxisome	protein binding		
YHR161C	YAP1801	Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family [Source:SGD;Acc:S000001204]	clathrin coat assembly, endocytosis	actin cortical patch, cellular bud, cellular bud neck, clathrin coat, cytoplasm, membrane, plasma membrane	1-phosphatidylinositol binding, clathrin binding, phospholipid binding		
YHR162W	YHR162W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion [Source:SGD;Acc:S000001205]	biological_process	mitochondrion	molecular_function		
YHR163W	SOL3	6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p [Source:SGD;Acc:S000001206]	carbohydrate metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch	cytoplasm, nucleus	6-phosphogluconolactonase activity, hydrolase activity		
YHR164C	DNA2	Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization [Source:SGD;Acc:S000001207]	DNA repair, DNA replication, DNA-dependent DNA replication, lagging strand elongation, meiotic DNA double-strand break processing, replicative cell aging, telomere maintenance	cytoplasm, nuclear chromosome, telomeric region, nucleus	5'-flap endonuclease activity, ATP binding, ATP-dependent DNA helicase activity, DNA binding, DNA strand annealing activity, helicase activity, hydrolase activity, nucleotide binding, single-stranded DNA specific endodeoxyribonuclease activity		
YHR165C	PRP8	Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa [Source:SGD;Acc:S000001208]	RNA splicing, assembly of spliceosomal tri-snRNP, mRNA processing, nuclear mRNA 3'-splice site recognition, nuclear mRNA splicing, via spliceosome	U4/U6 x U5 tri-snRNP complex, U5 snRNP, nucleus, ribonucleoprotein complex, spliceosomal complex	RNA binding, U5 snRNA binding, protein binding, second spliceosomal transesterification activity		
YHR165W-A	YHR165W-A	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028783]					
YHR166C	CDC23	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000001209]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, cyclin catabolic process, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, protein ubiquitination, regulation of mitotic metaphase/anaphase transition	anaphase-promoting complex, chromosome, centromeric region, condensed chromosome kinetochore, kinetochore, nucleus	binding, protein binding, ubiquitin-protein ligase activity		
YHR167W	THP2	Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance [Source:SGD;Acc:S000001210]	DNA recombination, mRNA export from nucleus, transcription elongation from RNA polymerase II promoter	THO complex part of transcription export complex, nucleoplasmic THO complex, nucleus	nucleic acid binding		
YHR168W	MTG2	Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly [Source:SGD;Acc:S000001211]	translation	extrinsic to membrane, intracellular, membrane, mitochondrial inner membrane, mitochondrion	GTP binding, GTPase activity, magnesium ion binding, nucleotide binding, ribosome binding		
YHR169W	DBP8	ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p [Source:SGD;Acc:S000001212]	auxin biosynthetic process, endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, nucleolus, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, ATPase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YHR170W	NMD3	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex [Source:SGD;Acc:S000001213]	protein transport, ribosomal large subunit export from nucleus, transport	cytoplasm, cytosol, cytosolic large ribosomal subunit, nucleoplasm, nucleus	ribosomal large subunit binding		
YHR171W	ATG7	Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation [Source:SGD;Acc:S000001214]	C-terminal protein lipidation, CVT pathway, autophagy, macroautophagy, metabolic process, mitochondrion degradation, piecemeal microautophagy of nucleus, protein modification by small protein conjugation, protein transport, transport	cytoplasm, cytosol, membrane, mitochondrion, pre-autophagosomal structure	APG12 activating enzyme activity, APG8 activating enzyme activity, binding, catalytic activity		
YHR172W	SPC97	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque [Source:SGD;Acc:S000001215]	microtubule cytoskeleton organization, microtubule nucleation	cytoplasm, cytoskeleton, gamma-tubulin small complex, spindle pole body, inner plaque of spindle pole body, microtubule, microtubule organizing center, nucleus, outer plaque of spindle pole body, spindle pole, spindle pole body	structural constituent of cytoskeleton		
YHR173C	YHR173C	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001216]					
YHR174W	ENO2	Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose [Source:SGD;Acc:S000001217]	gluconeogenesis, glycolysis, regulation of vacuole fusion, non-autophagic	cytoplasm, fungal-type vacuole, internal side of plasma membrane, mitochondrion, phosphopyruvate hydratase complex, plasma membrane enriched fraction, soluble fraction	lyase activity, magnesium ion binding, metal ion binding, phosphopyruvate hydratase activity		
YHR175W	CTR2	Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation [Source:SGD;Acc:S000001218]	copper ion import, copper ion transport, intracellular copper ion transport, ion transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	copper ion transmembrane transporter activity, copper uptake transmembrane transporter activity		
YHR175W-A	YHR175W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028553]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YHR176W	FMO1	Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins [Source:SGD;Acc:S000001219]	oxidation-reduction process, protein folding	endoplasmic reticulum membrane	NADP binding, flavin adenine dinucleotide binding, flavin-containing monooxygenase activity, monooxygenase activity, oxidoreductase activity		
YHR177W	YHR177W	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest [Source:SGD;Acc:S000001220]	biological_process	cellular_component	molecular_function		
YHR178W	STB5	Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro [Source:SGD;Acc:S000001221]	regulation of transcription from RNA polymerase II promoter in response to oxidative stress, regulation of transcription, DNA-dependent, response to xenobiotic stimulus	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YHR179W	OYE2	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death [Source:SGD;Acc:S000001222]	apoptosis, metabolic process, oxidation-reduction process	cytoplasm, mitochondrion, nucleus	FMN binding, NADPH dehydrogenase activity, catalytic activity, oxidoreductase activity		
YHR180C-B	YHR180C-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YHR180W-A [Source:SGD;Acc:S000028554]					
YHR180W	YHR180W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001223]					
YHR180W-A	YHR180W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3 [Source:SGD;Acc:S000028555]					
YHR181W	SVP26	Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment [Source:SGD;Acc:S000001224]	ER to Golgi vesicle-mediated transport, fungal-type cell wall organization, protein glycosylation, protein retention in Golgi apparatus	ER to Golgi transport vesicle, Golgi apparatus, endoplasmic reticulum, integral to Golgi membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane			
YHR182C-A	YHR182C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028784]					
YHR182W	YHR182W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm [Source:SGD;Acc:S000001225]	biological_process, signal transduction	cytoplasm, intracellular	molecular_function		
YHR183W	GND1	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress [Source:SGD;Acc:S000001226]	cellular response to oxidative stress, metabolic process, oxidation-reduction process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch	cytoplasm, mitochondrion	NADP binding, binding, catalytic activity, coenzyme binding, oxidoreductase activity, phosphogluconate dehydrogenase (decarboxylating) activity		
YHR184W	SSP1	Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis [Source:SGD;Acc:S000001227]	ascospore wall assembly, cell cycle, cell division, meiosis, protein complex assembly, sporulation resulting in formation of a cellular spore	membrane, prospore membrane	molecular_function		
YHR185C	PFS1	Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation [Source:SGD;Acc:S000001228]	ascospore wall assembly, sporulation resulting in formation of a cellular spore	cellular_component, cytoplasm, cytoskeleton, nucleus, spindle pole body	molecular_function		
YHR186C	KOG1	Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors [Source:SGD;Acc:S000001229]	TOR signaling cascade, cellular response to starvation, regulation of cell growth	TORC1 complex, fungal-type vacuole membrane, membrane, membrane fraction, mitochondrion, plasma membrane, vacuolar membrane, vacuole	binding, protein binding, ubiquitin binding		
YHR187W	IKI1	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin [Source:SGD;Acc:S000001230]	regulation of transcription from RNA polymerase II promoter, tRNA modification	Elongator holoenzyme complex, cytoplasm, nucleus	molecular_function		
YHR188C	GPI16	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog [Source:SGD;Acc:S000001231]	GPI anchor biosynthetic process, attachment of GPI anchor to protein	GPI-anchor transamidase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	GPI-anchor transamidase activity		
YHR189W	PTH1	One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium [Source:SGD;Acc:S000001232]	mitochondrial translation, translation	mitochondrion	aminoacyl-tRNA hydrolase activity, hydrolase activity		
YHR190W	ERG9	Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway [Source:SGD;Acc:S000001233]	biosynthetic process, cholesterol biosynthetic process, ergosterol biosynthetic process, isoprenoid biosynthetic process, lipid biosynthetic process, oxidation-reduction process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome, mitochondrial outer membrane	catalytic activity, farnesyl-diphosphate farnesyltransferase activity, oxidoreductase activity, squalene synthase activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups		
YHR191C	CTF8	Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion [Source:SGD;Acc:S000001234]	DNA replication, cell cycle, mitotic sister chromatid cohesion, response to DNA damage stimulus	Ctf18 RFC-like complex, nucleus	DNA binding, molecular_function		
YHR192W	YHR192W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000001235]	biological_process	cytoplasm, integral to membrane, membrane	molecular_function		
YHR193C	EGD2	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes [Source:SGD;Acc:S000001236]	'de novo' cotranslational protein folding, protein transport, transport	cytoplasm, nascent polypeptide-associated complex, nucleus	phosphatidic acid binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4-phosphate binding, unfolded protein binding		
YHR193C-A	YHR193C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified ORF MDM31 [Source:SGD;Acc:S000028785]					
YHR194W	MDM31	Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 [Source:SGD;Acc:S000001237]	cellular ion homeostasis, mitochondrion inheritance, mitochondrion organization	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion, nucleus	molecular_function		
YHR195W	NVJ1	Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) [Source:SGD;Acc:S000001238]	autophagy, cellular protein localization, microautophagy	integral to membrane, membrane, nuclear envelope, nuclear outer membrane, nucleus, viral envelope			
YHR196W	UTP9	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000001239]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of transcription from RNA polymerase I promoter, rRNA processing, ribosome biogenesis	90S preribosome, nucleolus, nucleus, rDNA heterochromatin, ribonucleoprotein complex, small-subunit processome, t-UTP complex	snoRNA binding		
YHR197W	RIX1	Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles [Source:SGD;Acc:S000001240]	rRNA processing, ribosomal large subunit assembly, ribosomal subunit export from nucleus, ribosome biogenesis	nucleoplasm, nucleus	molecular_function		
YHR198C	AIM18	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000001241]	biological_process, cellular modified amino acid biosynthetic process	mitochondrion	intramolecular lyase activity, molecular_function		
YHR199C	AIM46	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000001242]	biological_process, cellular modified amino acid biosynthetic process	mitochondrion	intramolecular lyase activity, molecular_function		
YHR199C-A	NBL1	Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p [Source:SGD;Acc:S000029704]	chromosome segregation	chromosome passenger complex	protein binding, bridging		
YHR200W	RPN10	Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein [Source:SGD;Acc:S000001243]	ubiquitin-dependent protein catabolic process	proteasome complex, proteasome regulatory particle, base subcomplex	polyubiquitin binding, protein binding, structural molecule activity		
YHR201C	PPX1	Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix [Source:SGD;Acc:S000001244]	polyphosphate catabolic process	cytoplasm, cytosol, mitochondrial matrix, plasma membrane	exopolyphosphatase activity, hydrolase activity, manganese ion binding, metal ion binding, pyrophosphatase activity		
YHR202W	YHR202W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization [Source:SGD;Acc:S000001245]	biological_process, nucleotide catabolic process	fungal-type vacuole, soluble fraction, vacuole	hydrolase activity, molecular_function		
YHR203C	RPS4B	Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein [Source:SGD;Acc:S000001246]	translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YHR204W	MNL1	alpha-1,2-specific exomannosidase of the endoplasmic reticulum that generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation [Source:SGD;Acc:S000001247]	ER-associated protein catabolic process, metabolic process, response to unfolded protein	endoplasmic reticulum, endoplasmic reticulum lumen, membrane	calcium ion binding, carbohydrate binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity		
YHR205W	SCH9	Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB [Source:SGD;Acc:S000001248]	age-dependent response to oxidative stress involved in chronological cell aging, auxin biosynthetic process, positive regulation of transcription from RNA polymerase I promoter, positive regulation of transcription from RNA polymerase III promoter, protein phosphorylation, regulation of cell size, regulation of protein localization, regulation of response to osmotic stress, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, replicative cell aging	chromatin, cytoplasm, fungal-type vacuole membrane, nucleus	ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YHR206W	SKN7	Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation [Source:SGD;Acc:S000001249]	regulation of cell size, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, regulation of transcription, DNA-dependent, response to osmotic stress, response to singlet oxygen, response to stress, two-component signal transduction system (phosphorelay)	nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, two-component response regulator activity		
YHR207C	SET5	Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus [Source:SGD;Acc:S000001250]	biological_process	cytoplasm, nucleus	methyltransferase activity, molecular_function, protein binding, transferase activity		
YHR208W	BAT1	Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase [Source:SGD;Acc:S000001251]	branched chain family amino acid biosynthetic process, branched chain family amino acid catabolic process, branched chain family amino acid metabolic process, cellular amino acid biosynthetic process, metabolic process	mitochondrial matrix, mitochondrion	branched-chain-amino-acid transaminase activity, catalytic activity, transaminase activity, transferase activity		
YHR209W	CRG1	mRNA binding protein and putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance [Source:SGD;Acc:S000001252]	biological_process, metabolic process	cellular_component, cytoplasm	S-adenosylmethionine-dependent methyltransferase activity, mRNA binding, methyltransferase activity, transferase activity		
YHR210C	YHR210C	Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10 [Source:SGD;Acc:S000001253]	biological_process, carbohydrate metabolic process, hexose metabolic process	cellular_component	carbohydrate binding, catalytic activity, isomerase activity, molecular_function		
YHR211W	FLO5	Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p [Source:SGD;Acc:S000001254]	flocculation, flocculation via cell wall protein-carbohydrate interaction	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	mannose binding		
YHR212C	YHR212C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001255]					
YHR212W-A	YHR212W-A	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028650]	biological_process	cellular_component	molecular_function		
YHR213W	YHR213W	Possible pseudogene; has similarity to Flo1p, which is a lectin-like protein involved in flocculation [Source:SGD;Acc:S000001256]	biological_process	cellular_component	molecular_function		
YHR213W-A	YHR213W-A	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028651]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YHR213W-B	YHR213W-B	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028652]	biological_process	cellular_component	molecular_function		
YHR214C-B	YHR214C-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000003534]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YHR214C-C	YHR214C-C	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007421]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding, nucleic acid binding		
YHR214C-D	YHR214C-D	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028653]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YHR214C-E	YHR214C-E	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028654]	biological_process	cellular_component	molecular_function		
YHR214W	YHR214W	Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein [Source:SGD;Acc:S000001257]	biological_process	cellular_component, extracellular region	molecular_function		
YHR214W-A	YHR214W-A	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; similar to the fungal specific protein encoded by YAR068W; induced by zinc deficiency [Source:SGD;Acc:S000003535]					
YHR215W	PHO12	One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; nearly identical to Pho11p; upregulated by phosphate starvation [Source:SGD;Acc:S000001258]	biological_process	fungal-type vacuole	acid phosphatase activity, hydrolase activity, phosphatase activity		
YHR216W	IMD2	Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio [Source:SGD;Acc:S000001259]	GMP biosynthetic process, GTP biosynthetic process, metabolic process, oxidation-reduction process, purine nucleotide biosynthetic process	chromatin, cytoplasm	IMP dehydrogenase activity, catalytic activity, chromatin binding, metal ion binding, oxidoreductase activity, protein binding		
YHR217C	YHR217C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R. [Source:SGD;Acc:S000001260]					
YHR218W	YHR218W	Helicase-like protein encoded within the telomeric Y' element [Source:SGD;Acc:S000001261]	biological_process	cellular_component	ATP binding, ATP-dependent helicase activity, helicase activity, molecular_function, nucleic acid binding		
YHR218W-A	YHR218W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028786]					
YHR219C-A	YHR219C-A	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028655]					
YHR219W	YHR219W	Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII [Source:SGD;Acc:S000001262]	biological_process	cellular_component	molecular_function		
YIL001W	YIL001W	Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm [Source:SGD;Acc:S000001263]	biological_process	cytoplasm	molecular_function, protein binding		
YIL002C	INP51	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth [Source:SGD;Acc:S000001264]	endocytosis, lipid metabolic process, phosphatidylinositol dephosphorylation, protein transport, transport	actin cortical patch, cytoplasm, cytoskeleton, membrane fraction	hydrolase activity, inositol or phosphatidylinositol phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, phosphoric ester hydrolase activity		
YIL002W-A	YIL002W-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028835]	biological_process	cellular_component	molecular_function		
YIL003W	CFD1	Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol [Source:SGD;Acc:S000001265]	iron-sulfur cluster assembly, tRNA wobble uridine modification	cytoplasm	4 iron, 4 sulfur cluster binding, ATP binding, ATPase activity, iron-sulfur cluster binding, metal ion binding, nucleotide binding		
YIL004C	BET1	Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins [Source:SGD;Acc:S000001266]	ER to Golgi vesicle-mediated transport, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, SNARE complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	SNAP receptor activity, protein binding		
YIL005W	EPS1	ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family [Source:SGD;Acc:S000001267]	ER-associated protein catabolic process, cell redox homeostasis, protein retention in ER lumen	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	chaperone binding, isomerase activity, protein disulfide isomerase activity, unfolded protein binding		
YIL006W	YIA6	Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs [Source:SGD;Acc:S000001268]	NAD transport, mitochondrial pyruvate transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	NAD transporter activity, binding, pyruvate secondary active transmembrane transporter activity, transporter activity		
YIL007C	NAS2	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p [Source:SGD;Acc:S000001269]	proteasome regulatory particle assembly, ubiquitin-dependent protein catabolic process	cytoplasm, cytosol, nucleus	molecular_function, protein binding		
YIL008W	URM1	Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response [Source:SGD;Acc:S000001270]	cell budding, cellular response to oxidative stress, invasive growth in response to glucose limitation, protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification	cytoplasm, nucleus	protein tag		
YIL009C-A	EST3	Component of the telomerase holoenzyme, involved in telomere replication [Source:SGD;Acc:S000006432]	DNA duplex unwinding, telomere maintenance via telomerase	chromosome, telomeric region, nucleus, telomerase holoenzyme complex	ATP-dependent DNA/RNA helicase activity, GTPase activity, telomeric DNA binding		
YIL009W	FAA3	Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000001271]	fatty acid metabolic process, lipid metabolic process, long-chain fatty acid metabolic process, metabolic process	cellular_component	ATP binding, catalytic activity, ligase activity, long-chain fatty acid-CoA ligase activity, nucleotide binding, very long-chain fatty acid-CoA ligase activity		
YIL010W	DOT5	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth [Source:SGD;Acc:S000001272]	cell redox homeostasis, cellular response to oxidative stress, oxidation-reduction process	chromosome, telomeric region, nucleus	antioxidant activity, oxidoreductase activity, peroxidase activity, peroxiredoxin activity, thioredoxin peroxidase activity		
YIL011W	TIR3	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth [Source:SGD;Acc:S000001273]	biological_process, response to stress	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YIL012W	YIL012W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001274]					
YIL013C	PDR11	ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth [Source:SGD;Acc:S000001275]	sterol transport, transport	integral to membrane, membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YIL014C-A	YIL014C-A	Putative protein of unknown function [Source:SGD;Acc:S000003536]	biological_process	cellular_component	molecular_function		
YIL014W	MNT3	Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation [Source:SGD;Acc:S000001276]	protein O-linked glycosylation	Golgi apparatus, Golgi membrane, cellular_component, integral to membrane, membrane	alpha-1,3-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YIL015W	BAR1	Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest [Source:SGD;Acc:S000001277]	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, peptide catabolic process, proteolysis, response to pheromone	cell wall-bounded periplasmic space, extracellular region	aspartic-type endopeptidase activity, hydrolase activity, peptidase activity		
YIL016W	SNL1	Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein [Source:SGD;Acc:S000001278]	apoptosis, nuclear pore organization, protein folding	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion, nuclear envelope, nuclear membrane, nucleus	molecular_function		
YIL017C	VID28	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm [Source:SGD;Acc:S000001279]	ascospore formation, negative regulation of gluconeogenesis, positive regulation of transcription from RNA polymerase II promoter, proteasomal ubiquitin-dependent protein catabolic process, vacuolar protein catabolic process	GID complex, cytoplasm, nucleus	binding, molecular_function		
YIL018W	RPL2B	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures [Source:SGD;Acc:S000001280]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YIL019W	FAF1	Protein required for pre-rRNA processing and 40S ribosomal subunit assembly [Source:SGD;Acc:S000001281]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosome biogenesis	cytoplasm, nucleolus, nucleus	molecular_function		
YIL020C	HIS6	Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts [Source:SGD;Acc:S000001282]	cellular amino acid biosynthetic process, histidine biosynthetic process, metabolic process	cytoplasm, intracellular	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity, catalytic activity, isomerase activity		
YIL020C-A	YIL020C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028787]					
YIL021C-A	YIL021C-A	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene RPB3/YIL021W; identified by gene-trapping, expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028656]					
YIL021W	RPB3	RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit [Source:SGD;Acc:S000001283]	termination of RNA polymerase II transcription, transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex, nucleoplasm, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding, protein dimerization activity		
YIL022W	TIM44	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex) [Source:SGD;Acc:S000001284]	intracellular protein transport, protein import into mitochondrial matrix, protein transport, transmembrane transport, transport	membrane, mitochondrial inner membrane, mitochondrial inner membrane presequence translocase complex, mitochondrion, presequence translocase-associated import motor	ATP binding, P-P-bond-hydrolysis-driven protein transmembrane transporter activity, chaperone binding, nucleotide binding, protein binding, bridging		
YIL023C	YKE4	Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family [Source:SGD;Acc:S000001285]	ion transport, metal ion transport, transmembrane transport, transport, zinc ion transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	metal ion transmembrane transporter activity, zinc ion transmembrane transporter activity		
YIL024C	YIL024C	Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p [Source:SGD;Acc:S000001286]	biological_process	cellular_component	molecular_function		
YIL025C	YIL025C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001287]					
YIL026C	IRR1	Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability [Source:SGD;Acc:S000001288]	cell cycle, cell division, chromosome segregation, cytogamy, fungal-type cell wall organization, mitosis, mitotic sister chromatid cohesion, spore germination	chromosome, chromosome, centromeric region, nuclear mitotic cohesin complex, nucleus	binding, chromatin binding		
YIL027C	KRE27	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance [Source:SGD;Acc:S000001289]	protein folding in endoplasmic reticulum	ER membrane protein complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YIL028W	YIL028W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001290]					
YIL029C	YIL029C	Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000001291]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YIL029W-A	YIL029W-A	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028788]					
YIL030C	SSM4	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation [Source:SGD;Acc:S000001292]	ER-associated protein catabolic process	Doa10p ubiquitin ligase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, nuclear envelope, nuclear inner membrane, nucleus	ligase activity, metal ion binding, ubiquitin-protein ligase activity, zinc ion binding		
YIL030W-A	YIL030W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIL031W. [Source:SGD;Acc:S000028789]					
YIL031W	ULP2	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate [Source:SGD;Acc:S000001293]	chromosome condensation, mitotic cell cycle spindle assembly checkpoint, plasmid maintenance, protein desumoylation, proteolysis	nucleus	SUMO-specific protease activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity		
YIL032C	YIL032C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001294]					
YIL033C	BCY1	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation [Source:SGD;Acc:S000001295]	negative regulation of Ras protein signal transduction, regulation of protein phosphorylation, signal transduction	cAMP-dependent protein kinase complex, cytoplasm, nucleus, plasma membrane	cAMP binding, cAMP-dependent protein kinase inhibitor activity, cAMP-dependent protein kinase regulator activity, nucleotide binding		
YIL034C	CAP2	Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches [Source:SGD;Acc:S000001296]	actin cytoskeleton organization, actin filament capping, barbed-end actin filament capping, filamentous growth	F-actin capping protein complex, actin cortical patch, actin filament, cellular bud, cellular bud tip, cytoplasm, cytoskeleton, mating projection tip	actin binding, actin filament binding		
YIL035C	CKA1	Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases [Source:SGD;Acc:S000001297]	protein phosphorylation, regulation of transcription from RNA polymerase I promoter, regulation of transcription from RNA polymerase III promoter, response to DNA damage stimulus	UTP-C complex, protein kinase CK2 complex	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YIL036W	CST6	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability [Source:SGD;Acc:S000001298]	DNA metabolic process, cellular response to oleic acid, regulation of transcription, DNA-dependent, transcription initiation from RNA polymerase II promoter	nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YIL037C	PRM2	Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion [Source:SGD;Acc:S000001299]	karyogamy involved in conjugation with cellular fusion	integral to membrane, membrane	molecular_function		
YIL038C	NOT3	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation [Source:SGD;Acc:S000001300]	nuclear-transcribed mRNA poly(A) tail shortening, protein ubiquitination, regulation of transcription from RNA polymerase II promoter	CCR4-NOT core complex, cytoplasm, nucleus	ubiquitin-protein ligase activity		
YIL039W	TED1	Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000001301]	ER to Golgi vesicle-mediated transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	hydrolase activity, molecular_function		
YIL040W	APQ12	Protein required for nuclear envelope morphology, nuclear pore complex localization, mRNA export from the nucleus; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism [Source:SGD;Acc:S000001302]	cellular lipid metabolic process, mRNA export from nucleus, nuclear envelope organization	endoplasmic reticulum, integral to membrane, membrane, nuclear envelope, nuclear membrane, nucleus	molecular_function		
YIL041W	GVP36	BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis [Source:SGD;Acc:S000001303]	endocytosis, establishment or maintenance of actin cytoskeleton polarity, vacuole organization	Golgi apparatus, Golgi membrane, cytoplasm, integral to Golgi membrane, membrane	molecular_function		
YIL042C	PKP1	Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p [Source:SGD;Acc:S000001304]	carbohydrate metabolic process, carbon utilization, glucose metabolic process, peptidyl-histidine phosphorylation, peptidyl-serine phosphorylation, phosphorylation, protein phosphorylation, signal transduction	mitochondrial matrix, mitochondrion	ATP binding, kinase activity, nucleotide binding, protein histidine kinase activity, protein kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity, transferase activity, transferase activity, transferring phosphorus-containing groups, two-component sensor activity		
YIL043C	CBR1	Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia [Source:SGD;Acc:S000001305]	biological_process, oxidation-reduction process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome, mitochondrial outer membrane, mitochondrion	cytochrome-b5 reductase activity, oxidoreductase activity		
YIL044C	AGE2	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif [Source:SGD;Acc:S000001306]	ER to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, regulation of ARF GTPase activity	Golgi apparatus, clathrin-coated vesicle, cytoplasm	ARF GTPase activator activity, GTPase activator activity, metal ion binding, zinc ion binding		
YIL045W	PIG2	Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase [Source:SGD;Acc:S000001307]	regulation of glycogen biosynthetic process	cytoplasm	protein binding, protein phosphatase type 1 regulator activity		
YIL046W	MET30	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus [Source:SGD;Acc:S000001308]	G1/S transition of mitotic cell cycle, M phase of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cellular amino acid biosynthetic process, cysteine biosynthetic process, methionine biosynthetic process, protein ubiquitination, regulation of DNA-dependent DNA replication initiation, regulation of transcription involved in G1 phase of mitotic cell cycle, response to arsenic-containing substance, response to cadmium ion	SCF ubiquitin ligase complex, cytoplasm, nuclear SCF ubiquitin ligase complex, nucleus	protein binding, ubiquitin binding		
YIL046W-A	YIL046W-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028836]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YIL047C	SYG1	Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency [Source:SGD;Acc:S000001309]	signal transduction	integral to membrane, membrane, mitochondrion, plasma membrane	molecular_function		
YIL047C-A	YIL047C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028790]					
YIL048W	NEO1	Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus [Source:SGD;Acc:S000001310]	ATP biosynthetic process, endocytosis, metabolic process, phospholipid transport, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vacuole organization	COPI-coated vesicle, Golgi apparatus, Golgi membrane, endosome, endosome membrane, integral to membrane, membrane	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, magnesium ion binding, nucleotide binding, phospholipid-translocating ATPase activity		
YIL049W	DFG10	Protein of unknown function, involved in filamentous growth [Source:SGD;Acc:S000001311]	dolichol biosynthetic process, lipid metabolic process, oxidation-reduction process, pseudohyphal growth	cellular_component, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors		
YIL050W	PCL7	Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated [Source:SGD;Acc:S000001312]	carbohydrate metabolic process, cell cycle, cell division, glycogen metabolic process, regulation of cyclin-dependent protein kinase activity, regulation of glycogen biosynthetic process, regulation of glycogen catabolic process, regulation of protein stability	cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus	cyclin-dependent protein kinase regulator activity		
YIL051C	MMF1	Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes [Source:SGD;Acc:S000001313]	isoleucine biosynthetic process, mitochondrial translation	mitochondrial matrix, mitochondrion	molecular_function		
YIL052C	RPL34B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein [Source:SGD;Acc:S000001314]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YIL053W	RHR2	Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress [Source:SGD;Acc:S000001315]	glycerol biosynthetic process, metabolic process, response to osmotic stress	cytoplasm, nucleus	catalytic activity, glycerol-1-phosphatase activity, hydrolase activity		
YIL054W	YIL054W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001316]					
YIL055C	YIL055C	Putative protein of unknown function [Source:SGD;Acc:S000001317]	biological_process	cellular_component	molecular_function		
YIL056W	VHR1	Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations [Source:SGD;Acc:S000001318]	biotin biosynthetic process, regulation of transcription from RNA polymerase II promoter	cytoplasm, nucleus	DNA binding		
YIL057C	RGI2	Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose [Source:SGD;Acc:S000001319]	energy reserve metabolic process	cytoplasm	molecular_function		
YIL058W	YIL058W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001320]					
YIL059C	YIL059C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W [Source:SGD;Acc:S000001321]					
YIL060W	YIL060W	Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene [Source:SGD;Acc:S000001322]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YIL061C	SNP1	Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein [Source:SGD;Acc:S000001323]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, commitment complex, nucleus, ribonucleoprotein complex, spliceosomal complex	RNA binding, U1 snRNA binding, mRNA binding, nucleic acid binding, nucleotide binding		
YIL062C	ARC15	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity [Source:SGD;Acc:S000001324]	actin cortical patch assembly, mitochondrion inheritance, regulation of actin filament polymerization	Arp2/3 protein complex, actin cortical patch, cytoplasm, cytoskeleton, extrinsic to mitochondrial outer membrane	mRNA binding, structural molecule activity		
YIL063C	YRB2	Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential [Source:SGD;Acc:S000001325]	intracellular transport, protein export from nucleus, protein transport, regulation of chromatin silencing at telomere, ribosomal small subunit export from nucleus, transport	nuclear pore, nucleus	GTPase activator activity, molecular_function		
YIL064W	SEE1	Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport [Source:SGD;Acc:S000001326]	metabolic process, peptidyl-lysine dimethylation, transport, vesicle-mediated transport	cytoplasm	methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity		
YIL065C	FIS1	Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation [Source:SGD;Acc:S000001327]	apoptosis, chronological cell aging, mitochondrial fission, peroxisome fission, peroxisome organization	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion, peroxisome	binding, molecular_function		
YIL066C	RNR3	Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits [Source:SGD;Acc:S000001328]	DNA replication, deoxyribonucleotide biosynthetic process, oxidation-reduction process	cytoplasm, mitochondrion, ribonucleoside-diphosphate reductase complex	ATP binding, catalytic activity, nucleotide binding, oxidoreductase activity, ribonucleoside-diphosphate reductase activity		
YIL066W-A	YIL066W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028791]					
YIL067C	YIL067C	Uncharacterized protein of unknown function [Source:SGD;Acc:S000001329]	biological_process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YIL068C	SEC6	Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly [Source:SGD;Acc:S000001330]	Golgi to plasma membrane transport, bipolar cellular bud site selection, cytokinesis, exocytosis, protein transport, transport, vesicle docking involved in exocytosis, vesicle fusion	cytoplasm, exocyst, mating projection tip	protein homodimerization activity		
YIL068W-A	YIL068W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028792]					
YIL069C	RPS24B	Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein [Source:SGD;Acc:S000001331]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	nucleotide binding, structural constituent of ribosome		
YIL070C	MAM33	Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R [Source:SGD;Acc:S000001332]	aerobic respiration	mitochondrial matrix, mitochondrion	molecular_function		
YIL071C	PCI8	Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain [Source:SGD;Acc:S000001333]	cullin deneddylation	cytoplasm, nucleus, signalosome	molecular_function, protein binding		
YIL071W-A	YIL071W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028793]					
YIL072W	HOP1	Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation [Source:SGD;Acc:S000001334]	meiosis, meiotic recombination checkpoint, mitosis, synapsis, synaptonemal complex assembly	chromosome, condensed nuclear chromosome, lateral element, nucleus	DNA binding, four-way junction DNA binding, metal ion binding		
YIL073C	SPO22	Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis [Source:SGD;Acc:S000001335]	meiosis, sporulation resulting in formation of a cellular spore, synapsis, synaptonemal complex assembly	condensed nuclear chromosome	binding, molecular_function		
YIL074C	SER33	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p [Source:SGD;Acc:S000001336]	L-serine biosynthetic process, cellular amino acid biosynthetic process, metabolic process, oxidation-reduction process, serine family amino acid biosynthetic process	cytoplasm	NAD binding, binding, catalytic activity, cofactor binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, phosphoglycerate dehydrogenase activity		
YIL075C	RPN2	Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p [Source:SGD;Acc:S000001337]	proteasome assembly, regulation of protein catabolic process, ubiquitin-dependent protein catabolic process	nucleus, proteasome complex, proteasome regulatory particle, base subcomplex, proteasome storage granule	binding, endopeptidase activity, enzyme regulator activity, protein binding, bridging		
YIL076W	SEC28	Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth [Source:SGD;Acc:S000001338]	ER to Golgi vesicle-mediated transport, late endosome to vacuole transport via multivesicular body sorting pathway, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle coating, vesicle-mediated transport	COPI coated vesicle membrane, COPI vesicle coat, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, endosome, membrane	binding, molecular_function, structural molecule activity		
YIL077C	YIL077C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000001339]	biological_process	mitochondrion	molecular_function		
YIL078W	THS1	Threonyl-tRNA synthetase, essential cytoplasmic protein [Source:SGD;Acc:S000001340]	tRNA aminoacylation, tRNA aminoacylation for protein translation, threonyl-tRNA aminoacylation, translation	cytoplasm, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, ligase activity, forming aminoacyl-tRNA and related compounds, nucleotide binding, threonine-tRNA ligase activity		
YIL079C	AIR1	Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p [Source:SGD;Acc:S000001341]	ncRNA polyadenylation, nuclear mRNA surveillance of mRNA 3'-end processing, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent snRNA catabolic process, nuclear polyadenylation-dependent snoRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process	TRAMP complex, cytoplasm, nucleolus, nucleus	metal ion binding, nucleic acid binding, polynucleotide adenylyltransferase activity, zinc ion binding		
YIL082W	YIL082W	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000001344]					
YIL082W-A	YIL082W-A	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000003537]	DNA integration, DNA recombination, RNA-dependent DNA replication, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity, zinc ion binding		
YIL083C	CAB2	Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) [Source:SGD;Acc:S000001345]	coenzyme A biosynthetic process	cytoplasm, nucleus	ligase activity, phosphopantothenate--cysteine ligase activity		
YIL084C	SDS3	Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes [Source:SGD;Acc:S000001346]	chromatin modification, chromatin silencing, histone deacetylation, negative regulation of chromatin silencing at telomere	Rpd3L complex, Rpd3L-Expanded complex, nucleus	histone deacetylase activity		
YIL085C	KTR7	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000001347]	fungal-type cell wall organization, protein N-linked glycosylation, protein glycosylation	Golgi apparatus, integral to membrane, membrane	glycolipid 2-alpha-mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YIL086C	YIL086C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001348]					
YIL087C	AIM19	Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth [Source:SGD;Acc:S000001349]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YIL088C	AVT7	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000001350]	amino acid transport, transport	fungal-type vacuole, integral to membrane, membrane, plasma membrane, vacuolar membrane, vacuole	transporter activity		
YIL089W	YIL089W	Putative protein of unknown function [Source:SGD;Acc:S000001351]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YIL090W	ICE2	Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells [Source:SGD;Acc:S000001352]	endoplasmic reticulum inheritance	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YIL091C	UTP25	Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis; contains a DEAD-box RNA helicase-like motif [Source:SGD;Acc:S000001353]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit biogenesis	nucleolus, nucleus, small-subunit processome	U3 snoRNA binding, rRNA binding		
YIL092W	YIL092W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus [Source:SGD;Acc:S000001354]	biological_process	cytoplasm, integral to membrane, membrane, nucleus	molecular_function		
YIL093C	RSM25	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000001355]	mitochondrial translation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YIL094C	LYS12	Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate [Source:SGD;Acc:S000001356]	cellular amino acid biosynthetic process, lysine biosynthetic process, oxidation-reduction process	mitochondrion	NAD binding, homoisocitrate dehydrogenase activity, magnesium ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YIL095W	PRK1	Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex [Source:SGD;Acc:S000001357]	actin cortical patch assembly, actin filament organization, cytokinesis, protein phosphorylation, regulation of endocytosis	actin cortical patch, cytoplasm, cytoskeleton, mating projection tip	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YIL096C	YIL096C	Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000001358]	biological_process	nucleolus, nucleus	molecular_function		
YIL097W	FYV10	Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of FBPase; contains CTLH domain; plays role in anti-apoptosis [Source:SGD;Acc:S000001359]	anti-apoptosis, negative regulation of gluconeogenesis, proteasomal ubiquitin-dependent protein catabolic process	GID complex, cytoplasm, nucleus	molecular_function		
YIL098C	FMC1	Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p [Source:SGD;Acc:S000001360]	mitochondrial proton-transporting ATP synthase complex assembly, response to stress	mitochondrial matrix, mitochondrion	molecular_function		
YIL099W	SGA1	Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation [Source:SGD;Acc:S000001361]	ascospore formation, carbohydrate metabolic process, glycogen catabolic process, metabolic process, polysaccharide catabolic process, polysaccharide metabolic process, sporulation resulting in formation of a cellular spore	fungal-type vacuole	catalytic activity, glucan 1,4-alpha-glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds		
YIL100C-A	YIL100C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028794]					
YIL100W	YIL100W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A [Source:SGD;Acc:S000001362]					
YIL101C	XBP1	Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate [Source:SGD;Acc:S000001363]	regulation of transcription, DNA-dependent, response to stress	nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YIL102C	YIL102C	Putative protein of unknown function [Source:SGD;Acc:S000001364]	biological_process	cellular_component	molecular_function		
YIL102C-A	YIL102C-A	Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species [Source:SGD;Acc:S000113587]	biological_process, macromolecule biosynthetic process	cellular_component, integral to endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YIL103W	DPH1	Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p [Source:SGD;Acc:S000001365]	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm	molecular_function		
YIL104C	SHQ1	Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones [Source:SGD;Acc:S000001366]	box H/ACA snoRNP assembly	nucleoplasm, nucleus	unfolded protein binding		
YIL105C	SLM1	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex [Source:SGD;Acc:S000001367]	TOR signaling cascade, actin cytoskeleton organization, actin filament bundle assembly, establishment or maintenance of actin cytoskeleton polarity, regulation of cell growth	cytoplasm, membrane, membrane raft, mitochondrion, plasma membrane, plasma membrane enriched fraction	phosphatidylinositol binding, protein binding		
YIL105W-A	YIL105W-A	Dubious open reading frame; completely overlaps the verified gene SLM1; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028657]					
YIL106W	MOB1	Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex [Source:SGD;Acc:S000001368]	cell cycle, cell division, protein phosphorylation, regulation of exit from mitosis	cellular bud neck, chromosome, centromeric region, cytoplasm, cytoskeleton, nucleus, spindle pole body	kinase regulator activity, metal ion binding		
YIL107C	PFK26	6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A [Source:SGD;Acc:S000001369]	fructose 2,6-bisphosphate metabolic process, fructose metabolic process, regulation of glycolysis	cytoplasm	6-phosphofructo-2-kinase activity, ATP binding, catalytic activity, fructose-2,6-bisphosphate 2-phosphatase activity, kinase activity, nucleotide binding, transferase activity		
YIL108W	YIL108W	Putative metalloprotease [Source:SGD;Acc:S000001370]	biological_process	cytoplasm	hydrolase activity, metal ion binding, metallopeptidase activity, molecular_function, peptidase activity		
YIL109C	SEC24	Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p [Source:SGD;Acc:S000001371]	ER to Golgi vesicle-mediated transport, cargo loading into COPII-coated vesicle, intracellular protein transport, protein transport, transport, vesicle-mediated transport	COPII vesicle coat, ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, membrane	metal ion binding, signal sequence binding, zinc ion binding		
YIL110W	HPM1	AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance [Source:SGD;Acc:S000001372]	peptidyl-histidine methylation, to form tele-methylhistidine	cytoplasm, nucleus	S-adenosylmethionine-dependent methyltransferase activity, protein-histidine N-methyltransferase activity		
YIL111W	COX5B	Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth [Source:SGD;Acc:S000001373]	mitochondrial electron transport, cytochrome c to oxygen, oxidation-reduction process	membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion	cytochrome-c oxidase activity, nitrite reductase (NO-forming) activity, oxidoreductase activity		
YIL112W	HOS4	Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate [Source:SGD;Acc:S000001374]	histone deacetylation, negative regulation of meiosis	Set3 complex	molecular_function, protein binding		
YIL113W	SDP1	Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock [Source:SGD;Acc:S000001375]	MAPKKK cascade involved in cell wall biogenesis, dephosphorylation, inactivation of MAPK activity involved in cell wall biogenesis, protein dephosphorylation	cytoplasm, nucleus	MAP kinase tyrosine phosphatase activity, hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity		
YIL114C	POR2	Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability [Source:SGD;Acc:S000001376]	DNA transport, anion transport, cell redox homeostasis, ion transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion, pore complex	porin activity, voltage-gated anion channel activity		
YIL115C	NUP159	Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, member of the Nup82 subcomplex, required for mRNA export [Source:SGD;Acc:S000001377]	mRNA export from nucleus, mRNA transport, nuclear pore organization, protein transport, rRNA export from nucleus, ribosomal subunit export from nucleus, transmembrane transport, transport	Nup82 complex, membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YIL115W-A	YIL115W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene NUP159/YIL115C [Source:SGD;Acc:S000028795]					
YIL116W	HIS5	Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts [Source:SGD;Acc:S000001378]	biosynthetic process, cellular amino acid biosynthetic process, histidine biosynthetic process, metabolic process	intracellular	catalytic activity, histidinol-phosphate transaminase activity, pyridoxal phosphate binding, transaminase activity, transferase activity, transferase activity, transferring nitrogenous groups		
YIL117C	PRM5	Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling [Source:SGD;Acc:S000001379]	biological_process	integral to membrane, membrane	molecular_function		
YIL118W	RHO3	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p [Source:SGD;Acc:S000001380]	establishment or maintenance of actin cytoskeleton polarity, positive regulation of exocytosis, positive regulation of formin-nucleated actin cable assembly, small GTPase mediated signal transduction	cellular bud, cytosol, intracellular, membrane, membrane fraction, plasma membrane, plasma membrane enriched fraction	GTP binding, GTPase activity, nucleotide binding		
YIL119C	RPI1	Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation [Source:SGD;Acc:S000001381]	Ras protein signal transduction, thiamine biosynthetic process	nucleus	DNA binding, small GTPase regulator activity		
YIL120W	QDR1	Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban [Source:SGD;Acc:S000001382]	drug transmembrane transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	drug transmembrane transporter activity		
YIL121W	QDR2	Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake [Source:SGD;Acc:S000001383]	drug transmembrane transport, ion transport, potassium ion import, potassium ion transport, transmembrane transport, transport	integral to membrane, integral to plasma membrane, membrane, plasma membrane	drug transmembrane transporter activity, transporter activity		
YIL122W	POG1	Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated [Source:SGD;Acc:S000001384]	cell cycle, cell division, mitosis, re-entry into mitotic cell cycle after pheromone arrest, response to stress	nuclear chromatin, nucleus			
YIL123W	SIM1	Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated [Source:SGD;Acc:S000001385]	fungal-type cell wall organization	fungal-type cell wall	molecular_function		
YIL124W	AYR1	NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones [Source:SGD;Acc:S000001386]	metabolic process, oxidation-reduction process, phosphatidic acid biosynthetic process	cytoplasm, endoplasmic reticulum, lipid particle, mitochondrial outer membrane, mitochondrion	acylglycerone-phosphate reductase activity, binding, catalytic activity, oxidoreductase activity		
YIL125W	KGD1	Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA [Source:SGD;Acc:S000001387]	2-oxoglutarate metabolic process, glycolysis, metabolic process, oxidation-reduction process, tricarboxylic acid cycle	mitochondrial matrix, mitochondrial nucleoid, mitochondrial oxoglutarate dehydrogenase complex, mitochondrion	oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamine pyrophosphate binding		
YIL126W	STH1	ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p [Source:SGD;Acc:S000001388]	ATP-dependent chromatin remodeling, G2/M transition of mitotic cell cycle, cell cycle, chromatin modification, chromatin remodeling at centromere, chromosome segregation, cytoskeleton organization, double-strand break repair, meiosis, nucleosome disassembly, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	ATP binding, ATPase activity, DNA binding, DNA-dependent ATPase activity, helicase activity, histone acetyl-lysine binding, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding		
YIL127C	RRT14	Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000001389]	biological_process	nucleolus	molecular_function		
YIL128W	MET18	DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance [Source:SGD;Acc:S000001390]	DNA repair, methionine metabolic process, nucleotide-excision repair, response to DNA damage stimulus, transcription from RNA polymerase II promoter	nucleoplasm, nucleus	binding		
YIL129C	TAO3	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p [Source:SGD;Acc:S000001391]	budding cell apical bud growth, cell budding, cell morphogenesis	cellular bud, incipient cellular bud site, mating projection tip, mitochondrion	binding, molecular_function		
YIL130W	ASG1	Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance [Source:SGD;Acc:S000001392]	biological_process, regulation of transcription, DNA-dependent, response to stress	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YIL131C	FKH1	Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching [Source:SGD;Acc:S000001393]	chromatin remodeling, chromatin silencing at silent mating-type cassette, donor selection, mRNA 3'-end processing, negative regulation of cell cycle, negative regulation of transcription from RNA polymerase II promoter, positive regulation of cell cycle, positive regulation of transcription involved in G2/M-phase of mitotic cell cycle, pseudohyphal growth, regulation of transcription, DNA-dependent, termination of RNA polymerase II transcription	nucleus	DNA binding, centromeric DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YIL132C	CSM2	Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, required for accurate chromosome segregation during meiosis [Source:SGD;Acc:S000001394]	DNA repair, meiosis, meiotic chromosome segregation, recombinational repair, response to DNA damage stimulus	cytoplasm, nucleus	molecular_function		
YIL133C	RPL16A	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p [Source:SGD;Acc:S000001395]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, large ribosomal subunit, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YIL134C-A	YIL134C-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028556]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YIL134W	FLX1	Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane [Source:SGD;Acc:S000001396]	FAD transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	FAD transmembrane transporter activity, binding		
YIL135C	VHS2	Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p [Source:SGD;Acc:S000001397]	G1/S transition of mitotic cell cycle, cell cycle	cytoplasm	molecular_function		
YIL136W	OM45	Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane [Source:SGD;Acc:S000001398]	biological_process	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YIL137C	TMA108	Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease [Source:SGD;Acc:S000001399]	proteolysis, ribosome biogenesis	cytoplasm, ribosome	aminopeptidase activity, hydrolase activity, metal ion binding, metallopeptidase activity, molecular_function, peptidase activity, zinc ion binding		
YIL138C	TPM2	Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p [Source:SGD;Acc:S000001400]	actin filament bundle assembly, actin filament organization, actin polymerization or depolymerization, budding cell apical bud growth, budding cell isotropic bud growth, establishment of cell polarity, exocytosis, intracellular mRNA localization, mitochondrion inheritance, vacuole inheritance, vesicle-mediated transport	actin filament bundle, cellular bud neck contractile ring, cytoplasm, cytoskeleton	actin lateral binding		
YIL139C	REV7	Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair [Source:SGD;Acc:S000001401]	DNA repair, error-free translesion synthesis, error-prone translesion synthesis, mitosis, response to DNA damage stimulus	mitochondrion, nuclear chromatin, zeta DNA polymerase complex	DNA-directed DNA polymerase activity		
YIL140W	AXL2	Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate [Source:SGD;Acc:S000001402]	axial cellular bud site selection, cellular bud site selection	cellular bud neck, integral to membrane, integral to plasma membrane, membrane, plasma membrane, septin ring	calcium ion binding, molecular_function		
YIL141W	YIL141W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001403]					
YIL142C-A	YIL142C-A	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028796]					
YIL142W	CCT2	Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [Source:SGD;Acc:S000001404]	cellular protein metabolic process, protein folding	chaperonin-containing T-complex, cytoplasm	ATP binding, nucleotide binding, unfolded protein binding		
YIL143C	SSL2	Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3 [Source:SGD;Acc:S000001405]	DNA repair, nucleotide-excision repair, nucleotide-excision repair, DNA incision, phosphorylation of RNA polymerase II C-terminal domain, poly(A)+ mRNA export from nucleus, regulation of mitotic recombination, regulation of transposition, RNA-mediated, response to DNA damage stimulus, transcription initiation from RNA polymerase II promoter	core TFIIH complex, holo TFIIH complex, nucleotide-excision repair factor 3 complex, nucleus	ATP binding, ATP-dependent DNA helicase activity, DNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YIL144W	TID3	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering [Source:SGD;Acc:S000001406]	cell cycle, cell division, chromosome segregation, microtubule nucleation, mitosis, protein localization to kinetochore	Ndc80 complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, condensed nuclear chromosome, centromeric region, kinetochore, nucleus	structural constituent of cytoskeleton		
YIL145C	PAN6	Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC [Source:SGD;Acc:S000001407]	pantothenate biosynthetic process	cytoplasm, nucleus	ATP binding, ligase activity, nucleotide binding, pantoate-beta-alanine ligase activity		
YIL146C	ATG32	Mitochondrial-anchored transmembrane receptor that interacts with the autophagy adaptor protein, Atg11p, and is essential for mitophagy, the selective vacuolar degradation of mitochondria in response to starvation [Source:SGD;Acc:S000001408]	autophagy, fungal-type cell wall organization, mitochondrion degradation	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion, vacuole	molecular_function		
YIL147C	SLN1	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators [Source:SGD;Acc:S000001409]	negative regulation of protein kinase activity, osmosensory signaling pathway via two-component system, peptidyl-histidine phosphorylation, phosphorylation, protein autophosphorylation, regulation of transcription, DNA-dependent, signal transduction, two-component signal transduction system (phosphorelay)	integral to membrane, membrane, plasma membrane	ATP binding, histidine phosphotransfer kinase activity, kinase activity, metal ion binding, nucleotide binding, osmosensor activity, protein histidine kinase activity, signal transducer activity, transferase activity, transferase activity, transferring phosphorus-containing groups, two-component response regulator activity, two-component sensor activity		
YIL148W	RPL40A	Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes [Source:SGD;Acc:S000001410]	DNA repair, protein ubiquitination, response to DNA damage stimulus, ribosome biogenesis, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, nucleus, ribonucleoprotein complex, ribosome	protein binding, protein tag, structural constituent of ribosome		
YIL149C	MLP2	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length [Source:SGD;Acc:S000001411]	mRNA export from nucleus, protein import into nucleus, spindle pole body organization	mitochondrion, nuclear envelope, nuclear pore, nucleoplasm, nucleus, ribonucleoprotein complex, spindle pole body	ribonucleoprotein binding		
YIL150C	MCM10	Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins [Source:SGD;Acc:S000001412]	DNA replication, DNA strand elongation involved in DNA replication, DNA-dependent DNA replication initiation, S phase of mitotic cell cycle, cell cycle, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, double-strand break repair via break-induced replication	nucleus, replication fork, replication fork protection complex	DNA replication origin binding, double-stranded DNA binding, metal ion binding, protein binding, single-stranded DNA binding		
YIL151C	YIL151C	Putative protein of unknown function, predicted to contain a PINc domain [Source:SGD;Acc:S000001413]	biological_process	cellular_component	ATP binding, molecular_function, nucleotide binding		
YIL152W	YIL152W	Putative protein of unknown function [Source:SGD;Acc:S000001414]	biological_process	cellular_component	molecular_function		
YIL153W	RRD1	Peptidyl-prolyl cis/trans-isomerase, activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex [Source:SGD;Acc:S000001415]	DNA repair, G1/S transition of mitotic cell cycle, mitotic spindle organization in nucleus, response to osmotic stress	cell fraction, cytoplasm, nucleus	isomerase activity, peptidyl-prolyl cis-trans isomerase activity, phosphatase activator activity, protein phosphatase type 2A regulator activity		
YIL154C	IMP2'	Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat [Source:SGD;Acc:S000001416]	DNA repair, cellular carbohydrate metabolic process	cytoplasm	transcription coactivator activity		
YIL155C	GUT2	Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner [Source:SGD;Acc:S000001417]	NADH oxidation, glycerol metabolic process, glycerol-3-phosphate metabolic process, oxidation-reduction process, replicative cell aging	glycerol-3-phosphate dehydrogenase complex, integral to mitochondrial outer membrane, membrane, mitochondrial inner membrane, mitochondrion	glycerol-3-phosphate dehydrogenase activity, oxidoreductase activity		
YIL156W	UBP7	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions [Source:SGD;Acc:S000001418]	protein deubiquitination, ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YIL156W-A	YIL156W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028797]					
YIL156W-B	YIL156W-B	Putative protein of unknown function, originally identified based on homology to <i>Ashbya gossypii</i> and other related yeasts [Source:SGD;Acc:S000028511]	biological_process	cellular_component	molecular_function		
YIL157C	COA1	Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly [Source:SGD;Acc:S000001419]	mitochondrial respiratory chain complex IV assembly	integral to membrane, integral to mitochondrial inner membrane, integral to mitochondrial membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YIL158W	AIM20	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000001420]	biological_process, cell cycle	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YIL159W	BNR1	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 [Source:SGD;Acc:S000001421]	actin cytoskeleton organization, actin filament bundle assembly, barbed-end actin filament capping, cellular component organization, formin-nucleated actin cable assembly	cellular bud neck	actin binding, binding, profilin binding		
YIL160C	POT1	3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids [Source:SGD;Acc:S000001422]	fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process, metabolic process	peroxisomal matrix, peroxisome	acetyl-CoA C-acyltransferase activity, acyltransferase activity, catalytic activity, transferase activity, transferase activity, transferring acyl groups other than amino-acyl groups		
YIL161W	YIL161W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene [Source:SGD;Acc:S000001423]	biological_process	cytoplasm	molecular_function		
YIL162W	SUC2	Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively [Source:SGD;Acc:S000001424]	carbohydrate metabolic process, metabolic process, sucrose catabolic process	cytoplasm, extracellular region, mitochondrion	beta-fructofuranosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds		
YIL163C	YIL163C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001425]					
YIL164C	NIT1	Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene [Source:SGD;Acc:S000001426]	biological_process, nitrogen compound metabolic process	cellular_component	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, nitrilase activity		
YIL165C	YIL165C	Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene [Source:SGD;Acc:S000001427]	mitochondrion degradation, nitrogen compound metabolic process	cellular_component	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, molecular_function		
YIL166C	YIL166C	Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene [Source:SGD;Acc:S000001428]	transmembrane transport, transport	integral to membrane, membrane	transporter activity		
YIL169C	YIL169C	Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene [Source:SGD;Acc:S000001431]	biological_process, signal transduction	cellular_component, membrane	molecular_function, protein binding, signal transducer activity		
YIL171W-A	YIL171W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028798]					
YIL172C	IMA3	Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose [Source:SGD;Acc:S000001434]	carbohydrate metabolic process, disaccharide catabolic process, maltose metabolic process, metabolic process	cytoplasm	alpha-glucosidase activity, catalytic activity, cation binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, oligo-1,6-glucosidase activity		
YIL173W	VTH1	Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting [Source:SGD;Acc:S000001435]	Golgi to vacuole transport, protein transport, transport	endosome, endosome membrane, integral to membrane, membrane	receptor activity, signal sequence binding		
YIL176C	PAU14	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau1p [Source:SGD;Acc:S000001438]	biological_process, response to stress	cellular_component	molecular_function		
YIL177C	YIL177C	Putative protein of unknown function; similarity to DNA helicases that are encoded within subtelomeric Y' elements and induced in telomerase deficient survivors [Source:SGD;Acc:S000001439]	biological_process	cellular_component	ATP binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YIL177W-A	YIL177W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YIL177C [Source:SGD;Acc:S000028658]					
YIR001C	SGN1	Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation [Source:SGD;Acc:S000001440]	mRNA metabolic process	cytoplasm	RNA binding, nucleic acid binding, nucleotide binding, poly(A) RNA binding		
YIR002C	MPH1	Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, binds to flap DNA and stimulates activity of Rad27p and Dna2p; mutations confer a mutator phenotype [Source:SGD;Acc:S000001441]	DNA repair, DNA replication, Okazaki fragment processing, negative regulation of strand invasion, response to DNA damage stimulus	nucleus	3'-5' DNA helicase activity, ATP binding, DNA binding, flap-structured DNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YIR003W	AIM21	Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton [Source:SGD;Acc:S000001442]	mitochondrion migration along actin filament	actin cortical patch, actin cytoskeleton, cytoplasm, cytoskeleton, mating projection tip, ribosome	molecular_function		
YIR004W	DJP1	Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ [Source:SGD;Acc:S000001443]	protein folding, protein import into peroxisome matrix	cytoplasm, cytosol	chaperone binding, heat shock protein binding, unfolded protein binding		
YIR005W	IST3	Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing [Source:SGD;Acc:S000001444]	RNA splicing, generation of catalytic spliceosome for first transesterification step, mRNA export from nucleus, mRNA processing, nuclear mRNA splicing, via spliceosome, spliceosome assembly	RES complex, U2 snRNP, cytoplasm, nucleus, spliceosomal complex	RNA binding, first spliceosomal transesterification activity, nucleic acid binding, nucleotide binding		
YIR006C	PAN1	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease [Source:SGD;Acc:S000001445]	actin cortical patch assembly, axial cellular bud site selection, bipolar cellular bud site selection, cytokinesis, endocytosis	actin cortical patch, cytoplasm, cytoskeleton, endosome, endosome membrane, mating projection tip, membrane, nucleus, plasma membrane	actin binding, calcium ion binding, protein binding, protein binding, bridging		
YIR007W	YIR007W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene [Source:SGD;Acc:S000001446]	biological_process, carbohydrate metabolic process, metabolic process	cytoplasm	catalytic activity, cation binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, molecular_function		
YIR008C	PRI1	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair [Source:SGD;Acc:S000001447]	DNA replication, DNA replication, synthesis of RNA primer, DNA-dependent DNA replication initiation, lagging strand elongation	alpha DNA polymerase:primase complex, nuclear replication fork	ATP binding, DNA primase activity, DNA-directed RNA polymerase activity, metal ion binding, nucleotide binding, nucleotidyltransferase activity, single-stranded DNA binding, transferase activity		
YIR009W	MSL1	U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members [Source:SGD;Acc:S000001448]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U2 snRNP, U2-type prespliceosome, nucleus, ribonucleoprotein complex	RNA binding, U2 snRNA binding, nucleic acid binding, nucleotide binding		
YIR010W	DSN1	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation [Source:SGD;Acc:S000001449]	cell cycle, cell division, chromosome segregation, mitosis	chromosome, centromeric region, condensed chromosome kinetochore, kinetochore, nuclear MIS12/MIND type complex, nucleus, spindle pole	molecular_function		
YIR011C	STS1	Protein that interacts with the karyopherin Srp1p; may have a role with Srp1p in ubiquitin-mediated protein degradation [Source:SGD;Acc:S000001450]	chromosome segregation, ubiquitin-dependent protein catabolic process	nucleus	molecular_function		
YIR012W	SQT1	Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay [Source:SGD;Acc:S000001451]	ribosomal large subunit assembly	cytoplasm, cytosol, cytosolic ribosome	molecular_function, protein binding		
YIR013C	GAT4	Protein containing GATA family zinc finger motifs [Source:SGD;Acc:S000001452]	regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YIR014W	YIR014W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene [Source:SGD;Acc:S000001453]	biological_process	fungal-type vacuole, integral to membrane, membrane	molecular_function		
YIR015W	RPR2	Subunit of nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits [Source:SGD;Acc:S000001454]	intronic box C/D snoRNA processing, tRNA processing	nucleolar ribonuclease P complex, nucleus	hydrolase activity, ribonuclease P activity		
YIR016W	YIR016W	Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; YIR016W is a non-essential gene [Source:SGD;Acc:S000001455]	biological_process	cellular_component	ATP binding, molecular_function, nucleotide binding		
YIR017C	MET28	Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism [Source:SGD;Acc:S000001456]	cellular amino acid biosynthetic process, cysteine biosynthetic process, methionine biosynthetic process, regulation of sulfur metabolic process, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, sulfur amino acid biosynthetic process	cytoplasm, nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YIR017W-A	YIR017W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028799]					
YIR018C-A	YIR018C-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028837]	biological_process	cellular_component	molecular_function		
YIR018W	YAP5	Basic leucine zipper (bZIP) transcription factor [Source:SGD;Acc:S000001457]	positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	cytoplasm, nuclear chromatin, nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YIR019C	MUC1	GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) [Source:SGD;Acc:S000001458]	biofilm formation, filamentous growth, flocculation, invasive growth in response to glucose limitation, pseudohyphal growth	anchored to membrane, cell wall, cellular bud neck, extracellular region, membrane, plasma membrane	molecular_function		
YIR020C	YIR020C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001459]					
YIR020C-B	YIR020C-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1 [Source:SGD;Acc:S000028800]					
YIR020W-A	YIR020W-A	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000007241]					
YIR021W	MRS1	Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA [Source:SGD;Acc:S000001460]	Group I intron splicing, mRNA processing	mitochondrial matrix, mitochondrion	RNA binding		
YIR021W-A	YIR021W-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028838]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YIR022W	SEC11	18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum [Source:SGD;Acc:S000001461]	protein targeting to ER, proteolysis, signal peptide processing	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, signal peptidase complex	hydrolase activity, peptidase activity, serine-type peptidase activity		
YIR023C-A	YIR023C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028801]					
YIR023W	DAL81	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism [Source:SGD;Acc:S000001462]	nitrogen utilization, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YIR024C	YIR024C	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect [Source:SGD;Acc:S000001463]	biological_process	mitochondrion	molecular_function		
YIR025W	MND2	Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase [Source:SGD;Acc:S000001464]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, mitosis, mitotic sister chromatid segregation, protein ubiquitination, reciprocal meiotic recombination, regulation of mitotic metaphase/anaphase transition	anaphase-promoting complex, nucleus	molecular_function		
YIR026C	YVH1	Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases [Source:SGD;Acc:S000001465]	ascospore wall assembly, cAMP-mediated signaling, dephosphorylation, meiosis, protein dephosphorylation, response to stress, ribosomal large subunit assembly	cytoplasm, nucleus, preribosome, large subunit precursor	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity		
YIR027C	DAL1	Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression [Source:SGD;Acc:S000001466]	allantoin assimilation pathway, allantoin catabolic process, purine base metabolic process	cellular_component	allantoinase activity, endodeoxyribonuclease activity, producing 5'-phosphomonoesters, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, metal ion binding, zinc ion binding		
YIR028W	DAL4	Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation [Source:SGD;Acc:S000001467]	allantoin catabolic process, allantoin transport, nucleobase, nucleoside, nucleotide and nucleic acid transport, purine base metabolic process, transmembrane transport, transport	integral to membrane, membrane	allantoin uptake transmembrane transporter activity, nucleobase transmembrane transporter activity		
YIR029W	DAL2	Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation [Source:SGD;Acc:S000001468]	allantoin catabolic process, purine base metabolic process	cellular_component	allantoicase activity, hydrolase activity		
YIR030C	DCG1	Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain [Source:SGD;Acc:S000001469]	nitrogen compound metabolic process	cellular_component	molecular_function		
YIR030W-A	YIR030W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028802]					
YIR031C	DAL7	Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation [Source:SGD;Acc:S000001470]	allantoin catabolic process, glyoxylate cycle, purine base metabolic process, tricarboxylic acid cycle	cellular_component, glyoxysome, peroxisome	catalytic activity, malate synthase activity, transferase activity		
YIR032C	DAL3	Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression [Source:SGD;Acc:S000001471]	allantoin catabolic process, purine base metabolic process	membrane, plasma membrane	hydrolase activity, ureidoglycolate hydrolase activity		
YIR033W	MGA2	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting [Source:SGD;Acc:S000001472]	fatty acid metabolic process, positive regulation of transcription from RNA polymerase II promoter, response to cold	endoplasmic reticulum membrane, integral to membrane, membrane, nucleus	protein binding		
YIR034C	LYS1	Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity [Source:SGD;Acc:S000001473]	cellular amino acid biosynthetic process, lysine biosynthetic process, lysine biosynthetic process via aminoadipic acid, metabolic process, oxidation-reduction process	cytoplasm	binding, catalytic activity, mRNA binding, oxidoreductase activity, saccharopine dehydrogenase (NAD+, L-lysine-forming) activity		
YIR035C	YIR035C	Putative cytoplasmic protein of unknown function [Source:SGD;Acc:S000001474]	biological_process, metabolic process, oxidation-reduction process	cytoplasm	binding, catalytic activity, molecular_function, oxidoreductase activity		
YIR036C	IRC24	Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci [Source:SGD;Acc:S000001475]	biological_process, metabolic process, oxidation-reduction process	cytoplasm	binding, catalytic activity, molecular_function, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YIR036W-A	YIR036W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028803]					
YIR037W	HYR1	Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor [Source:SGD;Acc:S000001476]	cellular response to oxidative stress, oxidation-reduction process, response to oxidative stress	cytoplasm, intracellular	glutathione peroxidase activity, oxidoreductase activity, peroxidase activity, peroxiredoxin activity, phospholipid-hydroperoxide glutathione peroxidase activity, thioredoxin peroxidase activity		
YIR038C	GTT1	ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p [Source:SGD;Acc:S000001477]	glutathione metabolic process	endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion, plasma membrane enriched fraction	glutathione peroxidase activity, glutathione transferase activity, protein binding, transferase activity		
YIR039C	YPS6	Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance [Source:SGD;Acc:S000001478]	fungal-type cell wall organization, proteolysis	anchored to membrane, fungal-type cell wall, membrane, plasma membrane	aspartic-type endopeptidase activity, hydrolase activity, peptidase activity		
YIR040C	YIR040C	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000001479]					
YIR041W	PAU15	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000001480]	biological_process, response to stress	cellular_component	molecular_function		
YIR042C	YIR042C	Putative protein of unknown function; YIR042C is a non-essential gene [Source:SGD;Acc:S000001481]	biological_process, metabolic process	cellular_component	N-acetyltransferase activity, molecular_function		
YJL001W	PRE3	Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides [Source:SGD;Acc:S000003538]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteolysis involved in cellular protein catabolic process	cytoplasm, endoplasmic reticulum membrane, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, peptidase activity, threonine-type endopeptidase activity		
YJL002C	OST1	Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins [Source:SGD;Acc:S000003539]	protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity, transferase activity		
YJL003W	COX16	Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase [Source:SGD;Acc:S000003540]	mitochondrial respiratory chain complex IV assembly	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion	molecular_function		
YJL004C	SYS1	Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation [Source:SGD;Acc:S000003541]	Golgi to endosome transport, Golgi to plasma membrane protein transport, protein transport, transport, vesicle organization	Golgi apparatus, Golgi membrane, integral to Golgi membrane, integral to membrane, membrane, trans-Golgi network	molecular_function		
YJL005W	CYR1	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation [Source:SGD;Acc:S000003542]	G-protein signaling, coupled to cAMP nucleotide second messenger, Ras protein signal transduction, cAMP biosynthetic process, cyclic nucleotide biosynthetic process, intracellular signal transduction, signal transduction	mitochondrion, plasma membrane	ATP binding, adenylate cyclase activity, catalytic activity, lyase activity, magnesium ion binding, metal ion binding, nucleotide binding, phosphorus-oxygen lyase activity, protein binding		
YJL006C	CTK2	Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity [Source:SGD;Acc:S000003543]	mRNA 3'-end processing, mRNA processing, positive regulation of transcription elongation, DNA-dependent, positive regulation of transcription from RNA polymerase I promoter, positive regulation of translational fidelity, protein phosphorylation, response to DNA damage stimulus	carboxy-terminal domain protein kinase complex, nucleolus, nucleoplasm, nucleus	cyclin-dependent protein kinase activity		
YJL007C	YJL007C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003544]					
YJL008C	CCT8	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [Source:SGD;Acc:S000003545]	cellular protein metabolic process, protein folding	chaperonin-containing T-complex, cytoplasm	ATP binding, nucleotide binding, unfolded protein binding		
YJL009W	YJL009W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex [Source:SGD;Acc:S000003546]					
YJL010C	NOP9	Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain [Source:SGD;Acc:S000003547]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit export from nucleus	90S preribosome, nucleolus, nucleus, preribosome, small subunit precursor	RNA binding, binding		
YJL011C	RPC17	RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex [Source:SGD;Acc:S000003548]	cellular metabolic process, tRNA transcription from RNA polymerase III promoter, transcription initiation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex, nucleus	DNA-directed RNA polymerase activity, catalytic activity, nucleotide binding		
YJL012C	VTC4	Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion [Source:SGD;Acc:S000003549]	microautophagy, polyphosphate metabolic process, vacuolar transport, vacuole fusion, non-autophagic	endoplasmic reticulum, integral to membrane, intrinsic to vacuolar membrane, membrane, vacuolar membrane, vacuolar transporter chaperone complex, vacuole	polyphosphate kinase activity		
YJL013C	MAD3	Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover [Source:SGD;Acc:S000003550]	cell cycle, cell cycle checkpoint, cell division, distributive segregation, mitosis, mitotic cell cycle G2/M transition decatenation checkpoint, mitotic cell cycle spindle assembly checkpoint	mitotic checkpoint complex, nucleus	molecular_function		
YJL014W	CCT3	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [Source:SGD;Acc:S000003551]	cellular protein metabolic process, protein folding	chaperonin-containing T-complex, cytoplasm	ATP binding, nucleotide binding, unfolded protein binding		
YJL015C	YJL015C	Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W [Source:SGD;Acc:S000003552]					
YJL016W	YJL016W	Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species [Source:SGD;Acc:S000003553]	biological_process	cytoplasm	molecular_function		
YJL019W	MPS3	Nuclear envelope protein required for SPB duplication and nuclear fusion; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement [Source:SGD;Acc:S000003556]	cell cycle, meiotic telomere clustering, mitotic sister chromatid cohesion, nuclear migration involved in conjugation with cellular fusion, spindle pole body duplication in nuclear envelope, synapsis, telomere tethering at nuclear periphery	cytoplasm, cytoskeleton, half bridge of spindle pole body, integral to membrane, membrane, nuclear chromosome, telomeric region, nuclear envelope, nuclear membrane, nuclear periphery, nucleus, spindle pole body	ATP binding, molecular_function, nucleotide binding		
YJL020C	BBC1	Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches [Source:SGD;Acc:S000003557]	actin cytoskeleton organization	actin cortical patch, cytoplasm, cytoskeleton	myosin I binding, protein binding		
YJL020W-A	YJL020W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL020C/BBC1 [Source:SGD;Acc:S000028659]					
YJL022W	YJL022W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 [Source:SGD;Acc:S000003559]					
YJL023C	PET130	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003560]	biological_process	mitochondrial matrix, mitochondrion	molecular_function		
YJL024C	APS3	Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function [Source:SGD;Acc:S000003561]	Golgi to vacuole transport, intracellular protein transport, protein transport, transport, vesicle-mediated transport	AP-3 adaptor complex, Golgi apparatus, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, membrane coat	molecular_function, protein transporter activity		
YJL025W	RRN7	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p [Source:SGD;Acc:S000003562]	transcription from RNA polymerase I promoter, transcription initiation from RNA polymerase I promoter, transcription of nuclear rRNA large RNA polymerase I transcript	RNA polymerase I core factor complex, nucleolus, nucleus			
YJL026C-A	YJL026C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2 [Source:SGD;Acc:S000028660]					
YJL026W	RNR2	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits [Source:SGD;Acc:S000003563]	DNA replication, deoxyribonucleoside diphosphate metabolic process, deoxyribonucleotide biosynthetic process, oxidation-reduction process	cytoplasm, nucleus, ribonucleoside-diphosphate reductase complex	metal ion binding, oxidoreductase activity, ribonucleoside-diphosphate reductase activity, transition metal ion binding		
YJL027C	YJL027C	Putative protein of unknown function [Source:SGD;Acc:S000003564]	biological_process	cellular_component	molecular_function		
YJL028W	YJL028W	Protein of unknown function; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000003565]	biological_process	integral to membrane, membrane, ribosome	molecular_function		
YJL029C	VPS53	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting [Source:SGD;Acc:S000003566]	Golgi to vacuole transport, protein transport, retrograde transport, endosome to Golgi, transport	GARP complex, Golgi apparatus, cytoplasm, endosome, endosome membrane, membrane			
YJL030W	MAD2	Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p [Source:SGD;Acc:S000003567]	cell cycle, cell division, chromosome decondensation, mitosis, mitotic cell cycle G2/M transition decatenation checkpoint, mitotic cell cycle spindle assembly checkpoint	condensed nuclear chromosome kinetochore, mitotic checkpoint complex, nuclear pore, nucleus	molecular_function		
YJL031C	BET4	Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p [Source:SGD;Acc:S000003568]	ER to Golgi vesicle-mediated transport, protein geranylgeranylation, protein prenylation, protein targeting to membrane	Rab-protein geranylgeranyltransferase complex	Rab geranylgeranyltransferase activity, prenyltransferase activity, protein prenyltransferase activity, transferase activity		
YJL032W	YJL032W	Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase [Source:SGD;Acc:S000003569]					
YJL033W	HCA4	Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis [Source:SGD;Acc:S000003570]	rRNA processing, ribosome biogenesis	nucleolus, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, RNA-dependent ATPase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YJL034W	KAR2	ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p [Source:SGD;Acc:S000003571]	ER-associated protein catabolic process, SRP-dependent cotranslational protein targeting to membrane, translocation, karyogamy involved in conjugation with cellular fusion, posttranslational protein targeting to membrane, translocation, response to stress, response to unfolded protein	endoplasmic reticulum, endoplasmic reticulum lumen, luminal surveillance complex	ATP binding, ATPase activity, nucleotide binding, unfolded protein binding		
YJL035C	TAD2	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs [Source:SGD;Acc:S000003572]	tRNA modification, tRNA processing	cytoplasm, nucleus	catalytic activity, hydrolase activity, metal ion binding, tRNA-specific adenosine deaminase activity, zinc ion binding		
YJL036W	SNX4	Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p [Source:SGD;Acc:S000003573]	CVT pathway, cell communication, early endosome to Golgi transport, mitochondrion degradation, piecemeal microautophagy of nucleus, protein targeting to vacuole, protein transport, transport	cytoplasm, cytosol, early endosome, endosome, endosome membrane, membrane, peripheral to membrane of membrane fraction, pre-autophagosomal structure	phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding		
YJL037W	IRC18	Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000003574]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YJL038C	LOH1	Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 [Source:SGD;Acc:S000003575]	chromosome organization, sporulation resulting in formation of a cellular spore	cellular_component, integral to membrane, membrane	molecular_function		
YJL039C	NUP192	Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205 [Source:SGD;Acc:S000003576]	mRNA transport, nuclear pore organization, protein transport, transmembrane transport, transport	integral to membrane, membrane, nuclear membrane, nuclear pore, nucleus	structural constituent of nuclear pore		
YJL041W	NSP1	Essential component of the nuclear pore complex, which mediates nuclear import and export, found in both the Nup82 and Nic96 complexes [Source:SGD;Acc:S000003577]	NLS-bearing substrate import into nucleus, RNA export from nucleus, cell cycle, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein import into nucleus, protein transport, rRNA export from nucleus, ribosomal large subunit export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	Nic96 complex, Nup82 complex, membrane, nuclear membrane, nuclear pore, nucleus	structural constituent of nuclear pore, structural molecule activity		
YJL042W	MHP1	Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins [Source:SGD;Acc:S000003578]	fungal-type cell wall organization, negative regulation of microtubule depolymerization	cytoplasm, cytoskeleton, microtubule, spindle	structural constituent of cytoskeleton		
YJL043W	YJL043W	Putative protein of unknown function; YJL043W is a non-essential gene [Source:SGD;Acc:S000003579]	biological_process	cytoplasm, mitochondrion	molecular_function		
YJL044C	GYP6	GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport [Source:SGD;Acc:S000003580]	intracellular protein transport, regulation of Rab GTPase activity	clathrin-coated vesicle, cytoplasm, endosome, intracellular	GTPase activator activity, Rab GTPase activator activity		
YJL045W	YJL045W	Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner [Source:SGD;Acc:S000003581]	cellular respiration, electron transport chain, oxidation-reduction process, transport, tricarboxylic acid cycle	membrane, mitochondrial inner membrane, mitochondrion	electron carrier activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, succinate dehydrogenase (ubiquinone) activity		
YJL046W	AIM22	Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000003582]	protein lipoylation, protein modification process	mitochondrion	ATP binding, catalytic activity, ligase activity, lipoate-protein ligase activity, nucleotide binding, transferase activity		
YJL047C	RTT101	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p [Source:SGD;Acc:S000003583]	negative regulation of transposition, RNA-mediated, nonfunctional rRNA decay, regulation of mitosis, replication fork processing, ubiquitin-dependent protein catabolic process	Cul8-RING ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, cytoplasm, nucleus	protein binding, ubiquitin protein ligase binding, ubiquitin-protein ligase activity		
YJL047C-A	YJL047C-A	Putative protein of unknown function [Source:SGD;Acc:S000028804]	biological_process	cellular_component	molecular_function		
YJL048C	UBX6	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline [Source:SGD;Acc:S000003584]	sporulation resulting in formation of a cellular spore, ubiquitin-dependent protein catabolic process	nucleus	molecular_function, protein binding		
YJL049W	YJL049W	Putative protein of unknown function; YJL049W is a non-essential gene [Source:SGD;Acc:S000003585]	biological_process, protein transport	cellular_component	molecular_function		
YJL050W	MTR4	ATP-dependent 3'-5' RNA helicase of the Dead-box family, involved in nuclear RNA processing and degradation both as a component of the TRAMP complex and in TRAMP independent processes; has a KOW domain that shows RNA binding activity [Source:SGD;Acc:S000003586]	U4 snRNA 3'-end processing, U5 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ncRNA polyadenylation, nuclear mRNA surveillance of mRNA 3'-end processing, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription, polyadenylation-dependent snoRNA 3'-end processing, rRNA catabolic process, rRNA processing	TRAMP complex, nucleolus, nucleus	ATP binding, ATP-dependent 3'-5' RNA helicase activity, ATP-dependent helicase activity, catalytic activity, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, nucleic acid binding, nucleotide binding, poly(A) RNA binding		
YJL051W	IRC8	Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc [Source:SGD;Acc:S000003587]	mitotic recombination	cellular bud, integral to membrane, membrane	molecular_function		
YJL052C-A	YJL052C-A	Putative protein of unknown function, identified based on comparison to related yeast species [Source:SGD;Acc:S000007610]	biological_process	cellular_component	molecular_function		
YJL052W	TDH1	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall [Source:SGD;Acc:S000003588]	gluconeogenesis, glucose metabolic process, glycolysis, metabolic process, oxidation-reduction process	cytoplasm, fungal-type cell wall, lipid particle, mitochondrion, plasma membrane enriched fraction	NAD binding, binding, catalytic activity, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, glyceraldehyde-3-phosphate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor		
YJL053W	PEP8	Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport [Source:SGD;Acc:S000003589]	protein retention in Golgi apparatus, protein transport, retrograde transport, endosome to Golgi, transport, vacuolar transport	endosome, retromer complex, retromer complex, inner shell	protein transporter activity		
YJL054W	TIM54	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane [Source:SGD;Acc:S000003590]	protein import into mitochondrial inner membrane, protein transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial inner membrane protein insertion complex, mitochondrion	protein channel activity		
YJL055W	YJL055W	Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU [Source:SGD;Acc:S000003591]	response to chemical stimulus, response to purine-containing compound	cytoplasm, nucleus	ATP binding, molecular_function, nucleotide binding		
YJL056C	ZAP1	Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains [Source:SGD;Acc:S000003592]	cellular zinc ion homeostasis, regulation of transcription from RNA polymerase II promoter	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YJL057C	IKS1	Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p [Source:SGD;Acc:S000003593]	biological_process, protein phosphorylation	cellular_component	ATP binding, kinase activity, molecular_function, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YJL058C	BIT61	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity [Source:SGD;Acc:S000003594]	TOR signaling cascade, establishment or maintenance of actin cytoskeleton polarity, fungal-type cell wall organization, regulation of cell growth	TORC2 complex, cytoplasm, membrane, plasma membrane, vacuolar membrane, vacuole	molecular_function		
YJL059W	YHC3	Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) [Source:SGD;Acc:S000003595]	amino acid transport, arginine transport, basic amino acid transport, regulation of intracellular pH, transport	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YJL060W	BNA3	Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate [Source:SGD;Acc:S000003596]	biosynthetic process, kynurenic acid biosynthetic process	cytoplasm, mitochondrion	1-aminocyclopropane-1-carboxylate synthase activity, catalytic activity, kynurenine-oxoglutarate transaminase activity, pyridoxal phosphate binding, transaminase activity, transferase activity, transferase activity, transferring nitrogenous groups		
YJL061W	NUP82	Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Gle2p, Nup159p, Nsp1p, and Nup116p and is required for proper localization of Nup116p in the NPC [Source:SGD;Acc:S000003597]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	Nup82 complex, membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YJL062W	LAS21	Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity [Source:SGD;Acc:S000003598]	GPI anchor biosynthetic process, metabolic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, integral to plasma membrane, membrane	catalytic activity, mannose-ethanolamine phosphotransferase activity, transferase activity		
YJL062W-A	COA3	Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly [Source:SGD;Acc:S000007611]	mitochondrial respiratory chain complex IV assembly, negative regulation of mitochondrial translation	integral to membrane, integral to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion	molecular_function		
YJL063C	MRPL8	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000003599]	mitochondrial genome maintenance, mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YJL064W	YJL064W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 [Source:SGD;Acc:S000003600]					
YJL065C	DLS1	Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing [Source:SGD;Acc:S000003601]	chromatin silencing at telomere	chromatin accessibility complex, intracellular, nucleus	DNA binding, molecular_function, sequence-specific DNA binding		
YJL066C	MPM1	Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches [Source:SGD;Acc:S000003602]	biological_process	membrane, membrane fraction, mitochondrial membrane, mitochondrion	molecular_function		
YJL067W	YJL067W	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003603]					
YJL068C	YJL068C	Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D [Source:SGD;Acc:S000003604]	formaldehyde catabolic process	cytoplasm, cytoplasmic membrane-bounded vesicle, cytosol	S-formylglutathione hydrolase activity, carboxylesterase activity, hydrolase activity		
YJL069C	UTP18	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data [Source:SGD;Acc:S000003605]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, Pwp2p-containing subcomplex of 90S preribosome, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	molecular_function, protein binding		
YJL070C	YJL070C	Putative protein of unknown function with similarity to AMP deaminases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL070C is a non-essential gene [Source:SGD;Acc:S000003606]	biological_process, purine base metabolic process, purine ribonucleoside monophosphate biosynthetic process	cytoplasm, mitochondrion	deaminase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, molecular_function		
YJL071W	ARG2	Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p [Source:SGD;Acc:S000003607]	arginine biosynthetic process, cellular amino acid biosynthetic process, ornithine biosynthetic process	mitochondrial matrix, mitochondrion	acetyl-CoA:L-glutamate N-acetyltransferase activity, acetylglutamate kinase activity, acyltransferase activity, transferase activity		
YJL072C	PSF2	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery [Source:SGD;Acc:S000003608]	DNA replication, DNA-dependent DNA replication, double-strand break repair via break-induced replication	DNA replication preinitiation complex, GINS complex, nuclear replication fork, nucleus, replication fork protection complex	molecular_function		
YJL073W	JEM1	DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 [Source:SGD;Acc:S000003609]	ER-associated protein catabolic process, karyogamy involved in conjugation with cellular fusion, protein folding, protein folding in endoplasmic reticulum	endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus, peripheral to membrane of membrane fraction	chaperone binding, heat shock protein binding, unfolded protein binding		
YJL074C	SMC3	Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member [Source:SGD;Acc:S000003610]	ascospore formation, cell cycle, cell division, chromosome organization, meiotic sister chromatid cohesion, mitosis, mitotic sister chromatid cohesion, reciprocal meiotic recombination, synaptonemal complex assembly	chromosome, nuclear mitotic cohesin complex, nucleus	ATP binding, ATPase activity, nucleotide binding, protein binding		
YJL075C	APQ13	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate [Source:SGD;Acc:S000003611]					
YJL076W	NET1	Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure [Source:SGD;Acc:S000003612]	cell cycle, cell division, chromatin silencing at rDNA, mitosis, nucleolus organization, regulation of exit from mitosis	RENT complex, nucleolus, nucleus	rDNA binding		
YJL077C	ICS3	Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2 [Source:SGD;Acc:S000003613]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YJL077W-A	YJL077W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL077C/ICS3 [Source:SGD;Acc:S000028661]					
YJL077W-B	YJL077W-B	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028662]	biological_process	cellular_component	molecular_function		
YJL078C	PRY3	Protein of unknown function [Source:SGD;Acc:S000003614]	biological_process	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YJL079C	PRY1	Protein of unknown function [Source:SGD;Acc:S000003615]	biological_process	endoplasmic reticulum, extracellular region, fungal-type vacuole, nuclear envelope	molecular_function		
YJL080C	SCP160	Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins [Source:SGD;Acc:S000003616]	chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, chromosome segregation, intracellular mRNA localization, meiotic telomere clustering, pheromone-dependent signal transduction involved in conjugation with cellular fusion	endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus, polysome	G-protein alpha-subunit binding, RNA binding		
YJL081C	ARP4	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes [Source:SGD;Acc:S000003617]	DNA repair, chromatin modification, chromatin organization, chromatin remodeling, histone acetylation, kinetochore assembly, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to DNA damage stimulus	Ino80 complex, NuA4 histone acetyltransferase complex, Swr1 complex, nuclear chromatin, nucleus	ATP-dependent 3'-5' DNA helicase activity, chromatin binding, histone acetyltransferase activity		
YJL082W	IML2	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003618]	biological_process	cytoplasm, integral to membrane, membrane, mitochondrial outer membrane, mitochondrion, nucleus	molecular_function		
YJL083W	TAX4	EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS [Source:SGD;Acc:S000003619]	autophagy, cellular response to starvation, fungal-type cell wall organization, inositol lipid-mediated signaling, lipid metabolic process	pre-autophagosomal structure	calcium ion binding, molecular_function, protein binding		
YJL084C	ALY2	Protein that promotes endocytosis of plasma membrane proteins; interacts with the cyclin Pcl7p and ubiquitin ligase Rsp5p; acts as an adaptor to bring together Rsp5p with substrate Dip5p; phosphorylated by cyclin-CDK complex Pcl7p-Pho85p [Source:SGD;Acc:S000003620]	positive regulation of ubiquitin-dependent endocytosis, ubiquitin-dependent endocytosis	cytoplasm	protein binding, bridging, ubiquitin protein ligase binding		
YJL085W	EXO70	Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding [Source:SGD;Acc:S000003621]	Golgi to plasma membrane transport, bipolar cellular bud site selection, cytokinesis, exocytosis, protein transport, transport, vesicle docking involved in exocytosis, vesicle fusion	cellular bud, cellular bud neck, exocyst, mating projection tip	phosphatidylinositol-4,5-bisphosphate binding		
YJL086C	YJL086C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 [Source:SGD;Acc:S000003622]					
YJL087C	TRL1	tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes [Source:SGD;Acc:S000003623]	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response, positive regulation of translation in response to stress, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation	nuclear inner membrane, polysome	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity, ATP binding, GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity, RNA ligase (ATP) activity, catalytic activity, endonuclease activity, hydrolase activity, kinase activity, ligase activity, nuclease activity, nucleotide binding, transferase activity		
YJL088W	ARG3	Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine [Source:SGD;Acc:S000003624]	arginine biosynthetic process, cellular amino acid biosynthetic process, cellular amino acid metabolic process, ornithine metabolic process	cytoplasm, cytosol, ornithine carbamoyltransferase complex	amino acid binding, carboxyl- or carbamoyltransferase activity, ornithine carbamoyltransferase activity, transferase activity		
YJL089W	SIP4	C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus [Source:SGD;Acc:S000003625]	invasive growth in response to glucose limitation, positive regulation of gluconeogenesis, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YJL090C	DPB11	Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1 [Source:SGD;Acc:S000003626]	DNA replication, DNA replication checkpoint, DNA-dependent DNA replication initiation, cell cycle, double-strand break repair via break-induced replication, lagging strand elongation, leading strand elongation, mating type switching, mismatch repair, mitotic cell cycle G2/M transition DNA damage checkpoint, nucleotide-excision repair, positive regulation of protein phosphorylation, recombinational repair	DNA replication preinitiation complex, epsilon DNA polymerase complex, intracellular, nucleus, replication fork	protein binding, protein kinase activator activity		
YJL091C	GWT1	Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors [Source:SGD;Acc:S000003627]	GPI anchor biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear outer membrane-endoplasmic reticulum membrane network	acyltransferase activity, glucosaminyl-phosphotidylinositol O-acyltransferase activity, transferase activity, transferase activity, transferring acyl groups		
YJL092W	SRS2	DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability [Source:SGD;Acc:S000003628]	DNA duplex unwinding, DNA repair, double-strand break repair via nonhomologous end joining, response to DNA damage stimulus	nucleus	ATP binding, ATP-dependent DNA helicase activity, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, nucleotide binding		
YJL093C	TOK1	Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin [Source:SGD;Acc:S000003629]	cellular potassium ion homeostasis, ion transport, potassium ion transport, transport	integral to membrane, membrane, plasma membrane	ion channel activity, potassium channel activity, voltage-gated ion channel activity		
YJL094C	KHA1	Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003630]	cation transport, ion transport, monovalent inorganic cation transport, potassium ion transport, transmembrane transport, transport	Golgi apparatus, integral to membrane, membrane, mitochondrion	antiporter activity, cation transmembrane transporter activity, potassium:hydrogen antiporter activity, solute:hydrogen antiporter activity		
YJL095W	BCK1	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p [Source:SGD;Acc:S000003631]	endoplasmic reticulum unfolded protein response, establishment of cell polarity, intracellular protein kinase cascade, peroxisome degradation, protein phosphorylation, response to acid, response to nutrient	cytoplasm, intracellular, mating projection tip	ATP binding, MAP kinase kinase kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity		
YJL096W	MRPL49	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000003632]	metabolic process, mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YJL097W	PHS1	Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking [Source:SGD;Acc:S000003633]	fatty acid biosynthetic process, lipid biosynthetic process, sphingolipid biosynthetic process, vacuolar transport	endoplasmic reticulum, endoplasmic reticulum membrane, fungal-type vacuole, fungal-type vacuole membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, nuclear outer membrane-endoplasmic reticulum membrane network, vacuolar membrane, vacuole	enoyl-CoA hydratase activity, lyase activity		
YJL098W	SAP185	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p [Source:SGD;Acc:S000003634]	G1/S transition of mitotic cell cycle, cell cycle, tRNA wobble uridine modification	cytoplasm, mitochondrion	protein serine/threonine phosphatase activity		
YJL099W	CHS6	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane [Source:SGD;Acc:S000003635]	Golgi to plasma membrane transport, fungal-type cell wall chitin biosynthetic process, protein transport, transport	Golgi apparatus, clathrin-coated vesicle, exomer complex, membrane, trans-Golgi network transport vesicle	binding, molecular_function, protein binding		
YJL100W	LSB6	Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization [Source:SGD;Acc:S000003636]	phosphatidylinositol phosphorylation	cytoplasm, fungal-type vacuole membrane, membrane, plasma membrane, vacuolar membrane, vacuole	1-phosphatidylinositol 4-kinase activity, ATP binding, kinase activity, metal ion binding, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YJL101C	GSH1	Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury [Source:SGD;Acc:S000003637]	glutathione biosynthetic process, response to cadmium ion, response to hydrogen peroxide	intracellular	ATP binding, glutamate-cysteine ligase activity, ligase activity, nucleotide binding		
YJL102W	MEF2	Mitochondrial elongation factor involved in translational elongation [Source:SGD;Acc:S000003638]	translation, translational elongation	mitochondrion	GTP binding, GTPase activity, nucleotide binding, translation elongation factor activity		
YJL103C	GSM1	Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis [Source:SGD;Acc:S000003639]	oxidative phosphorylation, regulation of transcription, DNA-dependent, sporulation resulting in formation of a cellular spore	cellular_component, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YJL104W	PAM16	Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain [Source:SGD;Acc:S000003640]	protein import into mitochondrial matrix, protein transport, transmembrane transport, transport	membrane, mitochondrial inner membrane, mitochondrial inner membrane presequence translocase complex, mitochondrion, presequence translocase-associated import motor	protein domain specific binding		
YJL105W	SET4	Protein of unknown function, contains a SET domain [Source:SGD;Acc:S000003641]	biological_process, chromatin modification	cellular_component	metal ion binding, molecular_function, protein binding, zinc ion binding		
YJL106W	IME2	Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p [Source:SGD;Acc:S000003642]	meiosis, protein phosphorylation, regulation of meiosis, sporulation resulting in formation of a cellular spore	nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YJL107C	YJL107C	Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi [Source:SGD;Acc:S000003643]	biological_process	cellular_component	molecular_function		
YJL108C	PRM10	Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000003644]	biological_process	integral to membrane, membrane	molecular_function		
YJL109C	UTP10	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000003645]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of transcription from RNA polymerase I promoter, rRNA processing, ribosome biogenesis	90S preribosome, mitochondrion, nucleolus, nucleus, preribosome, small subunit precursor, rDNA heterochromatin, ribonucleoprotein complex, small-subunit processome, t-UTP complex	binding, snoRNA binding		
YJL110C	GZF3	GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p [Source:SGD;Acc:S000003646]	nitrogen catabolite repression of transcription, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YJL111W	CCT7	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000003647]	cellular protein metabolic process, protein folding	chaperonin-containing T-complex, cytoplasm	ATP binding, nucleotide binding, unfolded protein binding		
YJL112W	MDV1	Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats [Source:SGD;Acc:S000003648]	mitochondrial fission, mitochondrial genome maintenance, peroxisome fission	membrane, mitochondrial outer membrane, mitochondrion	protein binding, ubiquitin binding		
YJL113W	YJL113W	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000003649]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, mitochondrion, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease activity, transferase activity, zinc ion binding		
YJL114W	YJL114W	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000003650]	transposition, RNA-mediated	retrotransposon nucleocapsid	RNA binding, nucleic acid binding, zinc ion binding		
YJL115W	ASF1	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000003651]	DNA replication-dependent nucleosome assembly, DNA replication-independent nucleosome assembly, chromatin assembly or disassembly, chromatin modification, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, histone acetylation, histone exchange, nucleosome disassembly, positive regulation of histone acetylation, regulation of transcription from RNA polymerase II promoter in response to stress	chromatin assembly complex, nucleus	histone binding		
YJL116C	NCA3	Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000003652]	mitochondrion organization	cellular_component, mitochondrion	molecular_function		
YJL117W	PHO86	Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles [Source:SGD;Acc:S000003653]	ER to Golgi vesicle-mediated transport, phosphate transport, protein folding, regulation of phosphate transport, transport	endoplasmic reticulum, integral to membrane, membrane	unfolded protein binding		
YJL118W	YJL118W	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein [Source:SGD;Acc:S000003654]	biological_process	integral to membrane, membrane, ribosome	molecular_function		
YJL119C	YJL119C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003655]					
YJL120W	YJL120W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO [Source:SGD;Acc:S000003656]					
YJL121C	RPE1	D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress [Source:SGD;Acc:S000003657]	carbohydrate metabolic process, metabolic process, pentose-phosphate shunt	cytoplasm, cytosol	catalytic activity, isomerase activity, ribulose-phosphate 3-epimerase activity		
YJL122W	ALB1	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p [Source:SGD;Acc:S000003658]	ribosomal large subunit biogenesis, ribosome biogenesis, transport	cytoplasm, nucleus, ribosome	molecular_function		
YJL123C	MTC1	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 [Source:SGD;Acc:S000003659]	biological_process	COPI-coated vesicle, Golgi apparatus, cytoplasm, ribosome	molecular_function		
YJL124C	LSM1	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs [Source:SGD;Acc:S000003660]	deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA processing, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	cytoplasm, cytoplasmic mRNA processing body, mRNA cap binding complex, nucleus, ribonucleoprotein complex	RNA binding, RNA cap binding		
YJL125C	GCD14	Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000003661]	tRNA methylation, tRNA processing	nucleus, tRNA (m1A) methyltransferase complex	methyltransferase activity, tRNA (adenine-N1-)-methyltransferase activity, transferase activity		
YJL126W	NIT2	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member [Source:SGD;Acc:S000003662]	biological_process, nitrogen compound metabolic process	cellular_component	hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds		
YJL127C	SPT10	Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box [Source:SGD;Acc:S000003663]	DNA repair, chromatin remodeling, chromatin silencing at rDNA, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, metabolic process	nucleus	N-acetyltransferase activity, histone acetyltransferase activity, sequence-specific DNA binding		
YJL127C-B	YJL127C-B	Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i> [Source:SGD;Acc:S000028522]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YJL127W-A	YJL127W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007612]					
YJL128C	PBS2	MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000003664]	MAPK import into nucleus involved in osmosensory signaling pathway, actin filament organization, activation of MAPK activity involved in osmosensory signaling pathway, hyperosmotic response, osmosensory signaling pathway, protein phosphorylation, response to antibiotic	cellular bud neck, cellular bud tip, cytoplasm	ATP binding, MAP kinase kinase activity, MAP-kinase scaffold activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity		
YJL129C	TRK1	Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation [Source:SGD;Acc:S000003665]	cation transport, cellular potassium ion homeostasis, ion transport, potassium ion transport, transmembrane transport, transport	integral to membrane, membrane, membrane raft	cation transmembrane transporter activity, potassium ion transmembrane transporter activity		
YJL130C	URA2	Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP [Source:SGD;Acc:S000003666]	'de novo' pyrimidine base biosynthetic process, cellular amino acid metabolic process, glutamine metabolic process, metabolic process, negative regulation of pyrimidine base metabolic process, nitrogen compound metabolic process, pyrimidine nucleotide biosynthetic process	cytoplasm, integral to membrane, mitochondrion	ATP binding, amino acid binding, aspartate carbamoyltransferase activity, carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, carbamoyl-phosphate synthase activity, carboxyl- or carbamoyltransferase activity, catalytic activity, ligase activity, nucleotide binding, transferase activity		
YJL131C	AIM23	Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000003667]	biological_process	mitochondrion	molecular_function		
YJL132W	YJL132W	Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene [Source:SGD;Acc:S000003668]	biological_process	integral to membrane, membrane, membrane fraction	molecular_function		
YJL133C-A	YJL133C-A	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000028805]	biological_process	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YJL133W	MRS3	Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs4p; active under low-iron conditions; may transport other cations [Source:SGD;Acc:S000003669]	RNA splicing, mRNA processing, mitochondrial iron ion transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, iron ion transmembrane transporter activity		
YJL134W	LCB3	Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids [Source:SGD;Acc:S000003670]	calcium-mediated signaling, lipid metabolic process, sphingolipid biosynthetic process, sphingolipid metabolic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	catalytic activity, hydrolase activity, sphingosine-1-phosphate phosphatase activity		
YJL135W	YJL135W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3 [Source:SGD;Acc:S000003671]					
YJL136C	RPS21B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein [Source:SGD;Acc:S000003672]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YJL136W-A	YJL136W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by SAGE [Source:SGD;Acc:S000028806]	biological_process	cellular_component	molecular_function		
YJL137C	GLG2	Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin [Source:SGD;Acc:S000003673]	glycogen biosynthetic process	cytoplasm	glycogenin glucosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YJL138C	TIF2	Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G [Source:SGD;Acc:S000003674]	regulation of translational initiation, translation, translational initiation	cytoplasm, eukaryotic translation initiation factor 4F complex, plasma membrane enriched fraction, ribosome	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, translation initiation factor activity		
YJL139C	YUR1	Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus [Source:SGD;Acc:S000003675]	cell wall mannoprotein biosynthetic process, protein N-linked glycosylation, protein glycosylation	Golgi apparatus, Golgi membrane, integral to membrane, membrane	glycolipid 2-alpha-mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YJL140W	RPB4	RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions [Source:SGD;Acc:S000003676]	DNA repair, cellular metabolic process, mRNA export from nucleus in response to heat stress, mRNA processing, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex, response to DNA damage stimulus, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex, cytoplasm, cytoplasmic mRNA processing body, nucleus	DNA-directed RNA polymerase activity, catalytic activity, nucleotide binding, single-stranded DNA binding, single-stranded RNA binding		
YJL141C	YAK1	Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal [Source:SGD;Acc:S000003677]	protein phosphorylation	cytoplasm, nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity		
YJL142C	IRC9	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000003678]					
YJL143W	TIM17	Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex [Source:SGD;Acc:S000003679]	intracellular protein transport, protein import into mitochondrial matrix, protein transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial inner membrane presequence translocase complex, mitochondrion	P-P-bond-hydrolysis-driven protein transmembrane transporter activity, protein channel activity, protein transporter activity		
YJL144W	YJL144W	Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS [Source:SGD;Acc:S000003680]	cellular response to water deprivation	cytoplasm	molecular_function		
YJL145W	SFH5	Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p [Source:SGD;Acc:S000003681]	lipid transport, phospholipid transport, transport	cortical endoplasmic reticulum, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, microsome	phosphatidylinositol transporter activity		
YJL146W	IDS2	Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation [Source:SGD;Acc:S000003682]	meiosis	cytoplasm, nucleus	molecular_function		
YJL147C	YJL147C	Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene [Source:SGD;Acc:S000003683]	biological_process	mitochondrion	molecular_function		
YJL148W	RPA34	RNA polymerase I subunit A34.5 [Source:SGD;Acc:S000003684]	transcription elongation from RNA polymerase I promoter, transcription of nuclear rRNA large RNA polymerase I transcript	DNA-directed RNA polymerase I complex, nucleolus, nucleus	DNA-directed RNA polymerase activity, molecular_function		
YJL149W	DAS1	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C [Source:SGD;Acc:S000003685]	biological_process	SCF ubiquitin ligase complex	molecular_function, protein binding		
YJL150W	YJL150W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003686]					
YJL151C	SNA3	Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting [Source:SGD;Acc:S000003687]	biological_process	cytoplasmic vesicle, cytoplasmic vesicle membrane, endosome, fungal-type vacuole lumen, integral to membrane, late endosome membrane, membrane, vacuolar lumen, vacuole	molecular_function		
YJL152W	YJL152W	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003688]					
YJL153C	INO1	Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element [Source:SGD;Acc:S000003689]	inositol biosynthetic process, metabolic process, phospholipid biosynthetic process	cytoplasm	binding, catalytic activity, inositol-3-phosphate synthase activity, isomerase activity		
YJL154C	VPS35	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval [Source:SGD;Acc:S000003690]	protein retention in Golgi apparatus, protein transport, retrograde transport, endosome to Golgi, transport	endosome, membrane, retromer complex, retromer complex, inner shell	protein transporter activity		
YJL155C	FBP26	Fructose-2,6-bisphosphatase, required for glucose metabolism [Source:SGD;Acc:S000003691]	fructose 2,6-bisphosphate metabolic process, fructose metabolic process, glucose metabolic process, metabolic process	cytosol	6-phosphofructo-2-kinase activity, ATP binding, catalytic activity, fructose-2,6-bisphosphate 2-phosphatase activity, hydrolase activity, nucleotide binding		
YJL156C	SSY5	Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p [Source:SGD;Acc:S000003692]	protein processing, response to amino acid stimulus	extrinsic to plasma membrane, membrane, plasma membrane	catalytic activity, hydrolase activity, peptidase activity, serine-type endopeptidase activity		
YJL156W-A	YJL156W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007613]					
YJL157C	FAR1	Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate [Source:SGD;Acc:S000003693]	cell cycle, cell cycle arrest in response to pheromone, cell division, maintenance of protein location in nucleus, pheromone-dependent signal transduction involved in conjugation with cellular fusion	cytoplasm, mating projection tip, membrane, nucleus	cyclin-dependent protein kinase inhibitor activity, metal ion binding, protein binding, protein kinase inhibitor activity, zinc ion binding		
YJL158C	CIS3	Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family [Source:SGD;Acc:S000003694]	cellular cell wall organization, fungal-type cell wall organization	cell wall, cellular bud tip, endoplasmic reticulum, extracellular region, fungal-type cell wall, plasma membrane	structural constituent of cell wall		
YJL159W	HSP150	O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation [Source:SGD;Acc:S000003695]	cellular cell wall organization, fungal-type cell wall organization, response to stress	cell wall, extracellular region, fungal-type cell wall	structural constituent of cell wall		
YJL160C	YJL160C	Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis [Source:SGD;Acc:S000003696]	biological_process	cell wall, cellular_component, extracellular region	molecular_function, structural constituent of cell wall		
YJL161W	FMP33	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003697]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YJL162C	JJJ2	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein [Source:SGD;Acc:S000003698]	biological_process, protein folding	cytoplasm, nucleus	heat shock protein binding, molecular_function, unfolded protein binding		
YJL163C	YJL163C	Putative protein of unknown function [Source:SGD;Acc:S000003699]	biological_process, transmembrane transport	cellular_component, integral to membrane, membrane	molecular_function		
YJL164C	TPK1	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p [Source:SGD;Acc:S000003700]	Ras protein signal transduction, cell cycle, cell division, protein phosphorylation	cAMP-dependent protein kinase complex, cytoplasm, nucleus	ATP binding, cAMP-dependent protein kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YJL165C	HAL5	Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters [Source:SGD;Acc:S000003701]	cellular cation homeostasis, cellular protein localization, protein dephosphorylation, protein phosphorylation	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YJL166W	QCR8	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p [Source:SGD;Acc:S000003702]	aerobic respiration, electron transport chain, mitochondrial electron transport, ubiquinol to cytochrome c, transport	membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex III, mitochondrion, respiratory chain	ubiquinol-cytochrome-c reductase activity		
YJL167W	ERG20	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis [Source:SGD;Acc:S000003703]	cholesterol biosynthetic process, ergosterol biosynthetic process, farnesyl diphosphate biosynthetic process, isoprenoid biosynthetic process, lipid biosynthetic process, steroid biosynthetic process, sterol biosynthetic process	cytoplasm, endoplasmic reticulum	dimethylallyltranstransferase activity, geranyltranstransferase activity, metal ion binding, transferase activity		
YJL168C	SET2	Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p [Source:SGD;Acc:S000003704]	ascospore formation, histone methylation, negative regulation of antisense RNA transcription, negative regulation of reciprocal meiotic recombination, positive regulation of histone acetylation, regulation of DNA-dependent DNA replication initiation, regulation of transcription, DNA-dependent, transcription elongation, DNA-dependent	chromosome, nucleus	histone methyltransferase activity, histone methyltransferase activity (H3-K36 specific), histone-lysine N-methyltransferase activity, methyltransferase activity, transferase activity		
YJL169W	YJL169W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2 [Source:SGD;Acc:S000003705]					
YJL170C	ASG7	Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor [Source:SGD;Acc:S000003706]	conjugation with cellular fusion	endomembrane system, integral to membrane, membrane, plasma membrane	molecular_function		
YJL171C	YJL171C	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein [Source:SGD;Acc:S000003707]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, fungal-type cell wall, integral to membrane, membrane, mitochondrion, plasma membrane enriched fraction	molecular_function		
YJL172W	CPS1	Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions [Source:SGD;Acc:S000003708]	metabolic process, nitrogen compound metabolic process, proteolysis, proteolysis involved in cellular protein catabolic process	fungal-type vacuole lumen, integral to membrane, membrane, vacuolar membrane, vacuole	carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity		
YJL173C	RFA3	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination [Source:SGD;Acc:S000003709]	DNA repair, DNA replication, DNA unwinding involved in replication, double-strand break repair via homologous recombination, establishment of protein localization, heteroduplex formation, mitotic recombination, nucleotide-excision repair, protein ubiquitination, reciprocal meiotic recombination, telomere maintenance via recombination, telomere maintenance via telomerase	DNA replication factor A complex, chromosome, telomeric region, condensed nuclear chromosome, nucleus	double-stranded DNA binding, sequence-specific DNA binding		
YJL174W	KRE9	Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects [Source:SGD;Acc:S000003710]	1,6-beta-glucan metabolic process, cell wall biogenesis, cellular cell wall organization, fungal-type cell wall organization	cell wall, extracellular region	molecular_function		
YJL175W	YJL175W	Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor [Source:SGD;Acc:S000003711]					
YJL176C	SWI3	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2 [Source:SGD;Acc:S000003712]	ATP-dependent chromatin remodeling, nucleosome mobilization, positive regulation of transcription, DNA-dependent	SWI/SNF complex, nucleus	DNA binding, protein binding		
YJL177W	RPL17B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins [Source:SGD;Acc:S000003713]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, large ribosomal subunit, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YJL178C	ATG27	Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site [Source:SGD;Acc:S000003714]	CVT pathway, autophagic vacuole assembly, autophagy, peroxisome degradation, protein localization to pre-autophagosomal structure, protein transport, transport, vesicle organization	Golgi apparatus, Golgi membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, integral to membrane, membrane, mitochondrial membrane, mitochondrion, pre-autophagosomal structure, trans-Golgi network	phosphatidylinositol-3-phosphate binding		
YJL179W	PFD1	Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin [Source:SGD;Acc:S000003715]	cytoskeleton organization, protein folding	prefoldin complex	unfolded protein binding		
YJL180C	ATP12	Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency [Source:SGD;Acc:S000003716]	mitochondrial proton-transporting ATP synthase complex assembly, proton-transporting ATP synthase complex assembly	mitochondrion	protein domain specific binding		
YJL181W	YJL181W	Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis [Source:SGD;Acc:S000003717]	biological_process	cellular_component	molecular_function		
YJL182C	YJL182C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W [Source:SGD;Acc:S000003718]					
YJL183W	MNN11	Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p [Source:SGD;Acc:S000003719]	protein glycosylation	Golgi apparatus, alpha-1,6-mannosyltransferase complex, integral to membrane, membrane	alpha-1,6-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups		
YJL184W	GON7	Component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; implicated in osmotic stress response [Source:SGD;Acc:S000003720]	cell wall mannoprotein biosynthetic process, positive regulation of transcription from RNA polymerase II promoter, telomere maintenance	EKC/KEOPS complex, chromosome, telomeric region, nuclear chromatin, nucleus	chromatin DNA binding		
YJL185C	YJL185C	Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene [Source:SGD;Acc:S000003721]	biological_process	cellular_component	molecular_function		
YJL186W	MNN5	Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment [Source:SGD;Acc:S000003722]	protein glycosylation	Golgi apparatus	alpha-1,2-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YJL187C	SWE1	Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate [Source:SGD;Acc:S000003723]	G2/M transition of mitotic cell cycle, cell cycle, cell division, cell shape checkpoint, meiosis, mitosis, negative regulation of spindle pole body separation, protein phosphorylation, re-entry into mitotic cell cycle, regulation of cell size, regulation of cyclin-dependent protein kinase activity, regulation of meiosis	cellular bud neck, nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity		
YJL188C	BUD19	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay [Source:SGD;Acc:S000003724]					
YJL189W	RPL39	Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1 [Source:SGD;Acc:S000003725]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YJL190C	RPS22A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins [Source:SGD;Acc:S000003726]	translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YJL191W	RPS14B	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins [Source:SGD;Acc:S000003727]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit assembly, ribosome biogenesis, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small-subunit processome	SSU rRNA binding, structural constituent of ribosome		
YJL192C	SOP4	ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER [Source:SGD;Acc:S000003728]	ER to Golgi vesicle-mediated transport, protein transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, integral to membrane of membrane fraction, membrane	molecular_function		
YJL193W	YJL193W	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect [Source:SGD;Acc:S000003729]	biological_process, transport	cellular_component, integral to membrane, membrane	molecular_function, transporter activity		
YJL194W	CDC6	Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p [Source:SGD;Acc:S000003730]	DNA replication, G1/S transition of mitotic cell cycle, cell cycle, cell division, pre-replicative complex assembly, regulation of DNA-dependent DNA replication initiation, regulation of chromatin silencing at telomere	DNA replication preinitiation complex, membrane, plasma membrane, pre-replicative complex	ATP binding, ATPase activity, DNA replication origin binding, GTP binding, GTPase activity, chromatin binding, nucleoside-triphosphatase activity, nucleotide binding, protein binding		
YJL195C	YJL195C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6 [Source:SGD;Acc:S000003731]					
YJL196C	ELO1	Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids [Source:SGD;Acc:S000003732]	fatty acid biosynthetic process, fatty acid elongation, unsaturated fatty acid, lipid biosynthetic process	integral to membrane, membrane	fatty acid elongase activity		
YJL197C-A	YJL197C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL197C/UBP12 [Source:SGD;Acc:S000028839]					
YJL197W	UBP12	Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins [Source:SGD;Acc:S000003733]	biological_process, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YJL198W	PHO90	Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth [Source:SGD;Acc:S000003734]	phosphate transport, sodium ion transport, transmembrane transport, transport	integral to membrane, membrane	phosphate transmembrane transporter activity, transporter activity		
YJL199C	MBB1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies [Source:SGD;Acc:S000003735]					
YJL200C	ACO2	Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol [Source:SGD;Acc:S000003736]	biological_process, metabolic process, tricarboxylic acid cycle	mitochondrion	4 iron, 4 sulfur cluster binding, aconitate hydratase activity, iron-sulfur cluster binding, lyase activity, metal ion binding		
YJL201W	ECM25	Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p [Source:SGD;Acc:S000003737]	cellular cell wall organization, filamentous growth, fungal-type cell wall organization, signal transduction	cytoplasm, intracellular	molecular_function		
YJL202C	YJL202C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex [Source:SGD;Acc:S000003738]					
YJL203W	PRP21	Subunit of the SF3a splicing factor complex, required for spliceosome assembly [Source:SGD;Acc:S000003739]	RNA processing, RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U2 snRNP, U2-type prespliceosome, nucleus, spliceosomal complex	RNA binding		
YJL204C	RCY1	F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth [Source:SGD;Acc:S000003740]	early endosome to Golgi transport, endocytosis, exocytosis, protein transport, transport, vesicle docking	Golgi apparatus, cell tip, cellular bud neck, cytoplasm, endosome, site of polarized growth	SNARE binding		
YJL205C	NCE101	Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences [Source:SGD;Acc:S000003742]	protein secretion, protein transport, transport	cellular_component, integral to membrane, membrane	molecular_function		
YJL206C	YJL206C	Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment [Source:SGD;Acc:S000003741]	biological_process, regulation of transcription, DNA-dependent	cellular_component, nucleus	DNA binding, metal ion binding, molecular_function, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YJL207C	LAA1	AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene [Source:SGD;Acc:S000003743]	protein localization, protein transport, retrograde transport, endosome to Golgi, transport	AP-1 adaptor complex, Golgi apparatus, clathrin-coated vesicle, ribosome	binding, molecular_function		
YJL208C	NUC1	Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy [Source:SGD;Acc:S000003744]	DNA catabolic process, DNA recombination, RNA catabolic process, apoptosis	membrane, mitochondrial inner membrane, mitochondrion, nucleus	endodeoxyribonuclease activity, endonuclease activity, exodeoxyribonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, ribonuclease activity		
YJL209W	CBP1	Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p [Source:SGD;Acc:S000003745]	aerobic respiration, mRNA processing, mitochondrial mRNA catabolic process	extrinsic to mitochondrial inner membrane, mitochondrion	mRNA binding		
YJL210W	PEX2	RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import [Source:SGD;Acc:S000003746]	peroxisome organization, protein import into peroxisome matrix	peroxisomal membrane, peroxisome	metal ion binding, protein binding, ubiquitin-protein ligase activity		
YJL211C	YJL211C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2 [Source:SGD;Acc:S000003747]					
YJL212C	OPT1	Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family [Source:SGD;Acc:S000003748]	oligopeptide transport, peptide transport, protein transport, sulfur compound metabolic process, transmembrane transport, transport	integral to membrane, integral to plasma membrane, membrane, plasma membrane	oligopeptide transporter activity, proton-dependent oligopeptide secondary active transmembrane transporter activity		
YJL213W	YJL213W	Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p [Source:SGD;Acc:S000003749]	biological_process	ribosome	hydrolase activity, molecular_function		
YJL214W	HXT8	Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose [Source:SGD;Acc:S000003750]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	fructose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YJL215C	YJL215C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003751]					
YJL216C	IMA5	Alpha-glucosidase with specificity for isomaltose, maltose, and palatinose; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose [Source:SGD;Acc:S000003752]	carbohydrate metabolic process, disaccharide catabolic process, maltose metabolic process, metabolic process	cellular_component	alpha-glucosidase activity, catalytic activity, cation binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, oligo-1,6-glucosidase activity		
YJL217W	REE1	Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle [Source:SGD;Acc:S000003753]	biological_process	cytoplasm	molecular_function		
YJL218W	YJL218W	Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene [Source:SGD;Acc:S000003754]	biological_process	cellular_component	acetyltransferase activity, acyltransferase activity, transferase activity		
YJL219W	HXT9	Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p [Source:SGD;Acc:S000003755]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	fructose transmembrane transporter activity, galactose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YJL220W	YJL220W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2 [Source:SGD;Acc:S000003756]					
YJL221C	IMA4	Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose [Source:SGD;Acc:S000003757]	carbohydrate metabolic process, disaccharide catabolic process, maltose metabolic process, metabolic process	cellular_component	alpha-glucosidase activity, catalytic activity, cation binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, oligo-1,6-glucosidase activity		
YJL222W	VTH2	Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting [Source:SGD;Acc:S000003758]	Golgi to vacuole transport, protein transport, transport	cellular_component, integral to membrane, membrane	receptor activity, signal sequence binding		
YJL222W-A	YJL222W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028663]					
YJL222W-B	YJL222W-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028664]					
YJL223C	PAU1	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme; identical to Pau14p [Source:SGD;Acc:S000003759]	biological_process, response to stress	cellular_component	molecular_function		
YJL225C	YJL225C	Putative protein of unknown function; similarity to DNA helicases that are also encoded within subtelomeric Y' elements and induced in telomerase deficient survivors [Source:SGD;Acc:S000003760]	biological_process	cellular_component	ATP binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YJL225W-A	YJL225W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YJL225C [Source:SGD;Acc:S000028665]					
YJR001W	AVT1	Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000003761]	amino acid transport, transport, vacuolar transport	fungal-type vacuole, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	L-glutamine transmembrane transporter activity, L-isoleucine transmembrane transporter activity, L-tyrosine transmembrane transporter activity, transporter activity		
YJR002W	MPP10	Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p [Source:SGD;Acc:S000003762]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, Mpp10 complex, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	molecular_function		
YJR003C	YJR003C	Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000003763]	biological_process	mitochondrion	molecular_function		
YJR004C	SAG1	Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor [Source:SGD;Acc:S000003764]	agglutination involved in conjugation with cellular fusion, cell adhesion	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	cell adhesion molecule binding		
YJR005C-A	YJR005C-A	Putative protein of unknown function, originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene [Source:SGD;Acc:S000028523]	biological_process	cellular_component	molecular_function		
YJR005W	APL1	Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex [Source:SGD;Acc:S000003765]	intracellular protein transport, protein transport, vesicle-mediated transport	AP-2 adaptor complex, coated pit, membrane, membrane coat, plasma membrane	binding, molecular_function, protein transporter activity		
YJR006W	POL31	DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair [Source:SGD;Acc:S000003766]	DNA replication, DNA replication, removal of RNA primer, RNA-dependent DNA replication, base-excision repair, lagging strand elongation, leading strand elongation, mismatch repair, nucleotide-excision repair, postreplication repair	delta DNA polymerase complex, nucleus	DNA binding, DNA-directed DNA polymerase activity, nucleotidyltransferase activity, single-stranded DNA specific 3'-5' exodeoxyribonuclease activity, transferase activity		
YJR007W	SUI2	Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP [Source:SGD;Acc:S000003767]	translation, translational initiation	cytoplasm, eukaryotic translation initiation factor 2 complex, multi-eIF complex, ribosome	RNA binding, translation initiation factor activity		
YJR008W	YJR008W	Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source. [Source:SGD;Acc:S000003768]	biological_process	cytoplasm, nucleus	molecular_function		
YJR009C	TDH2	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall [Source:SGD;Acc:S000003769]	apoptosis, gluconeogenesis, glucose metabolic process, glycolysis, metabolic process, oxidation-reduction process	cytoplasm, fungal-type cell wall, lipid particle, mitochondrion, plasma membrane enriched fraction	NAD binding, binding, catalytic activity, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, glyceraldehyde-3-phosphate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor		
YJR010C-A	SPC1	Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex [Source:SGD;Acc:S000003770]	protein targeting to ER, signal peptide processing	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, signal peptidase complex	molecular_function, peptidase activity		
YJR010W	MET3	ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism [Source:SGD;Acc:S000003771]	cellular amino acid biosynthetic process, cysteine biosynthetic process, methionine biosynthetic process, methionine metabolic process, sulfate assimilation	cytoplasm, mitochondrion	ATP binding, nucleotide binding, nucleotidyltransferase activity, sulfate adenylyltransferase (ATP) activity, transferase activity		
YJR011C	YJR011C	Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000003772]	biological_process	cellular_component	molecular_function		
YJR012C	YJR012C	Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W [Source:SGD;Acc:S000003773]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YJR013W	GPI14	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M [Source:SGD;Acc:S000003774]	GPI anchor biosynthetic process, cellular cell wall organization, fungal-type cell wall organization	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups		
YJR014W	TMA22	Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1 [Source:SGD;Acc:S000003775]	biological_process, translational initiation	cytoplasm, ribonucleoprotein complex, ribosome	RNA binding, translation initiation factor activity		
YJR015W	YJR015W	Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene [Source:SGD;Acc:S000003776]	biological_process	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YJR016C	ILV3	Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids [Source:SGD;Acc:S000003777]	branched chain family amino acid biosynthetic process, cellular amino acid biosynthetic process, metabolic process	mitochondrion	4 iron, 4 sulfur cluster binding, catalytic activity, dihydroxy-acid dehydratase activity, iron-sulfur cluster binding, lyase activity, metal ion binding		
YJR017C	ESS1	Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain [Source:SGD;Acc:S000003778]	mRNA processing, negative regulation of phosphorylation, negative regulation of transcription from RNA polymerase II promoter, protein folding, termination of RNA polymerase II transcription	cytoplasm, nucleus	isomerase activity, peptidyl-prolyl cis-trans isomerase activity, protein binding		
YJR018W	YJR018W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003779]					
YJR019C	TES1	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids [Source:SGD;Acc:S000003780]	acyl-CoA metabolic process, fatty acid beta-oxidation, fatty acid oxidation	mitochondrion, peroxisome	acyl-CoA thioesterase activity, carboxylesterase activity, hydrolase activity, palmitoyl-CoA hydrolase activity		
YJR020W	YJR020W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003781]					
YJR021C	REC107	Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation [Source:SGD;Acc:S000003782]	DNA recombination, meiosis, reciprocal meiotic recombination	chromosome, condensed nuclear chromosome, nucleus	molecular_function		
YJR022W	LSM8	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA [Source:SGD;Acc:S000003783]	mRNA processing, nuclear mRNA splicing, via spliceosome, rRNA processing, tRNA processing	U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, nucleolus, nucleus, ribonucleoprotein complex	RNA binding		
YJR023C	YJR023C	Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing [Source:SGD;Acc:S000003784]					
YJR024C	MDE1	5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant [Source:SGD;Acc:S000003785]	L-methionine salvage, L-methionine salvage from methylthioadenosine, cellular amino acid biosynthetic process, methionine biosynthetic process	cytoplasm	ion binding, lyase activity, metal ion binding, methylthioribulose 1-phosphate dehydratase activity		
YJR025C	BNA1	3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p [Source:SGD;Acc:S000003786]	de novo NAD biosynthetic process from tryptophan, metabolic process, oxidation-reduction process, pyridine nucleotide biosynthetic process	cytoplasm, nucleus	3-hydroxyanthranilate 3,4-dioxygenase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen		
YJR026W	YJR026W	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000003787]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YJR027W	YJR027W	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000003788]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YJR028W	YJR028W	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000003789]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YJR029W	YJR029W	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000003790]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YJR030C	YJR030C	Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; YJR030C is a non-essential gene [Source:SGD;Acc:S000003791]	biological_process	cellular_component	molecular_function		
YJR031C	GEA1	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p [Source:SGD;Acc:S000003792]	ER to Golgi vesicle-mediated transport, actin cytoskeleton organization, intra-Golgi vesicle-mediated transport, macroautophagy, regulation of ARF protein signal transduction, retrograde vesicle-mediated transport, Golgi to ER	Golgi cis cisterna, Golgi-associated vesicle, cytoplasm, cytosol, extrinsic to membrane, intracellular, membrane	ARF guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity		
YJR032W	CPR7	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity [Source:SGD;Acc:S000003793]	protein folding, protein refolding, response to stress	cytosol	binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity, protein binding, unfolded protein binding		
YJR033C	RAV1	Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate [Source:SGD;Acc:S000003794]	early endosome to late endosome transport, protein transport, regulation of protein complex assembly, transport, vacuolar acidification	RAVE complex, cytoplasm, endomembrane system, extrinsic to membrane, membrane	molecular_function, protein binding		
YJR034W	PET191	Protein required for assembly of cytochrome c oxidase; exists as an oligomer that is integral to the mitochondrial inner membrane and faces the intermembrane space; contains a twin Cx9C motif [Source:SGD;Acc:S000003795]	mitochondrial respiratory chain complex IV assembly	integral to mitochondrial inner membrane, mitochondrion	molecular_function		
YJR035W	RAD26	Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein [Source:SGD;Acc:S000003796]	DNA repair, nucleotide-excision repair, response to DNA damage stimulus, transcription-coupled nucleotide-excision repair	cytoplasm, nucleus	ATP binding, DNA binding, DNA-dependent ATPase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YJR036C	HUL4	Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability [Source:SGD;Acc:S000003797]	protein modification process, protein monoubiquitination, protein polyubiquitination	cellular_component, intracellular, nucleus	acid-amino acid ligase activity, ligase activity, ubiquitin-protein ligase activity		
YJR037W	YJR037W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces [Source:SGD;Acc:S000003798]					
YJR038C	YJR038C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003799]					
YJR039W	YJR039W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003800]	biological_process	mitochondrion	molecular_function		
YJR040W	GEF1	Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels [Source:SGD;Acc:S000003801]	cellular copper ion homeostasis, cellular iron ion homeostasis, chloride transport, ion transport, transmembrane transport, transport	Golgi apparatus, Golgi medial cisterna, chloride channel complex, endoplasmic reticulum, endosome, fungal-type vacuole, integral to membrane, membrane, plasma membrane	chloride channel activity, ion channel activity, protein binding, voltage-gated chloride channel activity, voltage-gated ion channel activity		
YJR041C	URB2	Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis [Source:SGD;Acc:S000003802]	rRNA metabolic process, rRNA processing, ribosome biogenesis	nucleolus, nucleus	molecular_function		
YJR042W	NUP85	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking [Source:SGD;Acc:S000003803]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear envelope organization, nuclear pore organization, protein export from nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	Nup107-160 complex, membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YJR043C	POL32	Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p [Source:SGD;Acc:S000003804]	DNA replication, DNA replication, removal of RNA primer, RNA-dependent DNA replication, base-excision repair, double-strand break repair via break-induced replication, lagging strand elongation, leading strand elongation, mismatch repair, nucleotide-excision repair, postreplication repair	delta DNA polymerase complex, nucleus	DNA-directed DNA polymerase activity, nucleotidyltransferase activity, single-stranded DNA specific 3'-5' exodeoxyribonuclease activity, transferase activity		
YJR044C	VPS55	Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) [Source:SGD;Acc:S000003805]	late endosome to vacuole transport via multivesicular body sorting pathway, protein transport, transport	Vps55/Vps68 complex, endosome, endosome membrane, integral to membrane, late endosome, membrane	molecular_function		
YJR045C	SSC1	Hsp70 family ATPase, constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease [Source:SGD;Acc:S000003806]	positive regulation of endodeoxyribonuclease activity, protein folding, protein import into mitochondrial matrix, protein refolding, protein unfolding, response to stress	TRC complex, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleus, presequence translocase-associated import motor	ATP binding, ATPase activity, enzyme regulator activity, nucleotide binding, unfolded protein binding		
YJR046W	TAH11	DNA replication licensing factor, required for pre-replication complex assembly [Source:SGD;Acc:S000003807]	double-strand break repair via break-induced replication, pre-replicative complex assembly, regulation of DNA-dependent DNA replication initiation	cytoplasm, nucleus, pre-replicative complex	DNA replication origin binding		
YJR047C	ANB1	Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions [Source:SGD;Acc:S000003808]	peptidyl-lysine modification to hypusine, positive regulation of translational elongation, positive regulation of translational termination, translation, translational frameshifting	cytoplasm, cytosolic ribosome	RNA binding, ribosome binding, translation elongation factor activity		
YJR048W	CYC1	Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration [Source:SGD;Acc:S000003809]	electron transport chain, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial electron transport, ubiquinol to cytochrome c, transport	mitochondrial intermembrane space, mitochondrion, respiratory chain	electron carrier activity, heme binding, iron ion binding, metal ion binding		
YJR049C	UTR1	ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p) [Source:SGD;Acc:S000003810]	NADP biosynthetic process, cellular iron ion homeostasis, metabolic process	cytoplasm, nucleus	ATP binding, NAD+ kinase activity, NADH kinase activity, kinase activity, nucleotide binding, transferase activity		
YJR050W	ISY1	Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles [Source:SGD;Acc:S000003811]	RNA splicing, generation of catalytic spliceosome for second transesterification step, mRNA processing, nuclear mRNA 3'-splice site recognition	Prp19 complex, U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, cytoplasm, nucleus, post-mRNA release spliceosomal complex, post-spliceosomal complex, spliceosomal complex	first spliceosomal transesterification activity, second spliceosomal transesterification activity		
YJR051W	OSM1	Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity [Source:SGD;Acc:S000003812]	cellular response to anoxia, oxidation-reduction process	cytoplasm, mitochondrion	electron carrier activity, fumarate reductase (NADH) activity, oxidoreductase activity, succinate dehydrogenase activity		
YJR052W	RAD7	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex [Source:SGD;Acc:S000003813]	DNA repair, nucleotide-excision repair, DNA damage recognition, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, response to DNA damage stimulus	Cul3-RING ubiquitin ligase complex, nucleotide-excision repair factor 4 complex	DNA-dependent ATPase activity, damaged DNA binding, ubiquitin-protein ligase activity		
YJR053W	BFA1	Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis [Source:SGD;Acc:S000003814]	cell cycle, cell division, mitosis, mitotic cell cycle spindle orientation checkpoint, regulation of exit from mitosis	cytoplasm, cytoskeleton, spindle pole, spindle pole body	GTPase activator activity		
YJR054W	YJR054W	Vacuolar protein of unknown function; potential Cdc28p substrate [Source:SGD;Acc:S000003815]	biological_process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YJR055W	HIT1	Protein of unknown function, required for growth at high temperature [Source:SGD;Acc:S000003816]	biological_process	cytoplasm, nucleus	metal ion binding, molecular_function		
YJR056C	YJR056C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000003817]	biological_process	cytoplasm, nucleus	molecular_function		
YJR057W	CDC8	Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p [Source:SGD;Acc:S000003818]	dTDP biosynthetic process, dTTP biosynthetic process, dUDP biosynthetic process, nucleotide biosynthetic process	cytoplasm, nucleus	ATP binding, kinase activity, nucleotide binding, thymidylate kinase activity, transferase activity, uridylate kinase activity		
YJR058C	APS2	Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex [Source:SGD;Acc:S000003819]	intracellular protein transport, protein transport, transport, vesicle-mediated transport	AP-2 adaptor complex, coated pit, membrane, membrane coat, plasma membrane	molecular_function, protein transporter activity		
YJR059W	PTK2	Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake [Source:SGD;Acc:S000003820]	G1/S transition of mitotic cell cycle, cellular ion homeostasis, polyamine transport, protein phosphorylation, regulation of cell size	cytoplasm, nucleus, plasma membrane	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YJR060W	CBF1	Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA [Source:SGD;Acc:S000003821]	chromatin assembly or disassembly, chromosome segregation, methionine biosynthetic process	chromosome, centromeric region, kinetochore, mitochondrion, nucleus	DNA binding, centromeric DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YJR061W	YJR061W	Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p [Source:SGD;Acc:S000003822]	biological_process	cellular_component	molecular_function		
YJR062C	NTA1	Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation [Source:SGD;Acc:S000003823]	nitrogen compound metabolic process, protein catabolic process, protein modification process	mitochondrion	hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, protein N-terminal asparagine amidohydrolase activity		
YJR063W	RPA12	RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex [Source:SGD;Acc:S000003824]	termination of RNA polymerase I transcription, transcription of nuclear rRNA large RNA polymerase I transcript	DNA-directed RNA polymerase I complex, nucleolus, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding, molecular_function, nucleic acid binding, zinc ion binding		
YJR064W	CCT5	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [Source:SGD;Acc:S000003825]	cellular protein metabolic process, protein folding	chaperonin-containing T-complex, cytoplasm	ATP binding, nucleotide binding, unfolded protein binding		
YJR065C	ARP3	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity [Source:SGD;Acc:S000003826]	Arp2/3 complex-mediated actin nucleation, actin filament organization, mitochondrion inheritance, regulation of actin filament polymerization	Arp2/3 protein complex, actin cortical patch, cytoplasm, cytoskeleton, plasma membrane enriched fraction	ATP binding, actin binding, nucleotide binding		
YJR066W	TOR1	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis [Source:SGD;Acc:S000003827]	G1 phase of mitotic cell cycle, TOR signaling cascade, cell cycle, fungal-type cell wall organization, meiosis, mitochondria-nucleus signaling pathway, negative regulation of autophagy, regulation of cell cycle, regulation of cell growth, response to DNA damage stimulus, ribosome biogenesis, signal transduction, transcription of nuclear rRNA large RNA polymerase I transcript	Golgi membrane, TORC1 complex, cytoplasm, endosome membrane, extrinsic to internal side of plasma membrane, membrane, membrane fraction, nucleus, plasma membrane, vacuolar membrane, vacuole	ATP binding, binding, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, transferase activity, transferring phosphorus-containing groups		
YJR067C	YAE1	Protein of unknown function, essential for growth under standard (aerobic) conditions but not under anaerobic conditions [Source:SGD;Acc:S000003828]	biological_process	cytoplasm, nucleus	molecular_function		
YJR068W	RFC2	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [Source:SGD;Acc:S000003829]	DNA replication, cell cycle, cell cycle checkpoint, leading strand elongation, mismatch repair, sister chromatid cohesion	Ctf18 RFC-like complex, DNA replication factor C complex, Elg1 RFC-like complex, Rad17 RFC-like complex, nucleus	ATP binding, DNA binding, DNA clamp loader activity, nucleoside-triphosphatase activity, nucleotide binding, purine nucleotide binding		
YJR069C	HAM1	Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine [Source:SGD;Acc:S000003830]	deoxyribonucleoside triphosphate catabolic process, response to DNA damage stimulus	cytoplasm, nucleus	hydrolase activity, nucleoside-triphosphate diphosphatase activity		
YJR070C	LIA1	Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning [Source:SGD;Acc:S000003831]	microtubule cytoskeleton organization, oxidation-reduction process, peptidyl-lysine modification to hypusine	cytoplasm, nucleus	binding, deoxyhypusine monooxygenase activity, metal ion binding, monooxygenase activity, oxidoreductase activity		
YJR071W	YJR071W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003832]					
YJR072C	NPA3	Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex [Source:SGD;Acc:S000003833]	biological_process	cytoplasm	ATPase activity, GTP binding, hydrolase activity, nucleotide binding		
YJR073C	OPI3	Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis [Source:SGD;Acc:S000003834]	phosphatidylcholine biosynthetic process, phospholipid biosynthetic process, phospholipid metabolic process	integral to membrane, membrane, microsome, mitochondrion	N-methyltransferase activity, methylene-fatty-acyl-phospholipid synthase activity, methyltransferase activity, phosphatidyl-N-dimethylethanolamine N-methyltransferase activity, phosphatidyl-N-methylethanolamine N-methyltransferase activity, transferase activity		
YJR074W	MOG1	Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p [Source:SGD;Acc:S000003835]	mRNA transport, protein import into nucleus, protein transport, transport	nucleus	Ran GTPase binding		
YJR075W	HOC1	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele [Source:SGD;Acc:S000003836]	cell wall mannoprotein biosynthetic process, substituted mannan metabolic process	Golgi apparatus, alpha-1,6-mannosyltransferase complex, integral to membrane, membrane	alpha-1,6-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YJR076C	CDC11	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM [Source:SGD;Acc:S000003837]	axial cellular bud site selection, cell cycle, cell division, cell morphogenesis, conjugation with cellular fusion, cytokinesis, establishment of cell polarity, fungal-type cell wall organization	ascospore wall, cellular bud neck, cellular bud neck septin ring, mating projection base, mating projection tip, membrane, prospore membrane, septin complex	1-phosphatidylinositol binding, GTP binding, nucleotide binding, structural constituent of cytoskeleton		
YJR077C	MIR1	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated [Source:SGD;Acc:S000003838]	phosphate transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion	binding, inorganic phosphate transmembrane transporter activity		
YJR078W	BNA2	Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp [Source:SGD;Acc:S000003839]	de novo NAD biosynthetic process from tryptophan, oxidation-reduction process	cytoplasm	heme binding, indoleamine 2,3-dioxygenase activity, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, tryptophan 2,3-dioxygenase activity		
YJR079W	YJR079W	Putative protein of unknown function; mutation results in impaired mitochondrial respiration [Source:SGD;Acc:S000003840]	biological_process	cellular_component	molecular_function		
YJR080C	AIM24	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000003841]	biological_process	mitochondrion	molecular_function		
YJR082C	EAF6	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 [Source:SGD;Acc:S000003842]	DNA repair, chromatin modification, histone acetylation, response to DNA damage stimulus	NuA3 histone acetyltransferase complex, NuA4 histone acetyltransferase complex, nucleus	histone acetyltransferase activity		
YJR083C	ACF4	Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate [Source:SGD;Acc:S000003843]	biological_process	cellular_component	molecular_function		
YJR084W	YJR084W	Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome [Source:SGD;Acc:S000003844]	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, nuclear mRNA splicing, via spliceosome	cytoplasm, nucleus, signalosome, transcriptionally active chromatin	molecular_function		
YJR085C	YJR085C	Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003845]	biological_process	integral to membrane, membrane, mitochondrion	molecular_function		
YJR086W	STE18	G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling [Source:SGD;Acc:S000003846]	G-protein coupled receptor protein signaling pathway, heterotrimeric G-protein complex cycle, pheromone-dependent signal transduction involved in conjugation with cellular fusion, response to pheromone, signal transduction	cytoplasm, heterotrimeric G-protein complex, membrane, plasma membrane	signal transducer activity		
YJR087W	YJR087W	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene STE18 and uncharacterized ORF YJR088C [Source:SGD;Acc:S000003847]					
YJR088C	EMC2	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response [Source:SGD;Acc:S000003848]	protein folding in endoplasmic reticulum	ER membrane protein complex, endoplasmic reticulum	binding, molecular_function, protein binding		
YJR089W	BIR1	Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension [Source:SGD;Acc:S000003849]	apoptosis, cell cycle, cell division, chromosome segregation, mitotic spindle elongation, sister chromatid biorientation, spindle checkpoint	chromosome passenger complex, condensed nuclear chromosome kinetochore, cytoplasm, intracellular, mitochondrion, nucleus, spindle, spindle midzone	metal ion binding, molecular_function		
YJR090C	GRR1	F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification [Source:SGD;Acc:S000003850]	G1/S transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, carbohydrate metabolic process, cell cycle arrest in response to pheromone, glucose metabolic process, protein ubiquitination, response to DNA damage stimulus	SCF ubiquitin ligase complex, cellular bud neck contractile ring, cytoplasm, membrane, nucleus	protein binding, protein binding, bridging, ubiquitin-protein ligase activity		
YJR091C	JSN1	Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl [Source:SGD;Acc:S000003851]	cellular protein complex localization, establishment of mitochondrion localization, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	external side of mitochondrial outer membrane	RNA binding, binding, mRNA binding, nucleic acid binding, nucleotide binding		
YJR092W	BUD4	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate [Source:SGD;Acc:S000003852]	axial cellular bud site selection, cell cycle, cell division, cellular bud site selection	cellular bud neck, cellular bud neck contractile ring	GTP binding, protein binding		
YJR093C	FIP1	Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p [Source:SGD;Acc:S000003853]	mRNA cleavage, mRNA polyadenylation, mRNA processing	mRNA cleavage and polyadenylation specificity factor complex, nucleus	RNA binding, protein binding, bridging		
YJR094C	IME1	Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p [Source:SGD;Acc:S000003854]	meiosis, sporulation resulting in formation of a cellular spore	nucleus			
YJR094W-A	RPL43B	Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein [Source:SGD;Acc:S000003855]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	metal ion binding, structural constituent of ribosome		
YJR095W	SFC1	Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization [Source:SGD;Acc:S000003856]	fumarate transport, succinate transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, succinate:fumarate antiporter activity		
YJR096W	YJR096W	Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000003857]	D-xylose catabolic process, arabinose catabolic process, cellular response to oxidative stress, oxidation-reduction process	cytoplasm, nucleus	alditol:NADP+ 1-oxidoreductase activity, aldo-keto reductase (NADP) activity, oxidoreductase activity		
YJR097W	JJJ3	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein [Source:SGD;Acc:S000003858]	peptidyl-diphthamide biosynthetic process from peptidyl-histidine, protein folding	cytoplasm, nucleus	heat shock protein binding, metal ion binding, molecular_function, unfolded protein binding		
YJR098C	YJR098C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003859]	biological_process, lipid metabolic process	cytoplasm, mitochondrion	molecular_function, phosphatidylcholine-sterol O-acyltransferase activity		
YJR099W	YUH1	Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p [Source:SGD;Acc:S000003860]	protein deubiquitination, ubiquitin-dependent protein catabolic process	cytoplasm, intracellular	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YJR100C	AIM25	Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000003861]	biological_process	mitochondrion	molecular_function		
YJR101W	RSM26	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000003862]	mitochondrial translation, oxidation-reduction process, superoxide metabolic process	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	metal ion binding, structural constituent of ribosome, superoxide dismutase activity		
YJR102C	VPS25	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome [Source:SGD;Acc:S000003863]	negative regulation of transcription from RNA polymerase II promoter by glucose, protein targeting to vacuole, protein transport, transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ESCRT II complex, cytoplasm, endosome, endosome membrane, membrane			
YJR103W	URA8	Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis [Source:SGD;Acc:S000003864]	CTP biosynthetic process, glutamine metabolic process, phospholipid biosynthetic process, pyrimidine base biosynthetic process, pyrimidine nucleotide biosynthetic process	cytoplasm, cytosol	ATP binding, CTP synthase activity, catalytic activity, ligase activity, nucleotide binding		
YJR104C	SOD1	Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans [Source:SGD;Acc:S000003865]	age-dependent response to reactive oxygen species involved in chronological cell aging, cellular copper ion homeostasis, cellular zinc ion homeostasis, fungal-type cell wall organization, oxidation-reduction process, positive regulation of sequence-specific DNA binding transcription factor activity, superoxide metabolic process	cytoplasm, cytosol, mitochondrial intermembrane space, mitochondrion, nucleus	antioxidant activity, metal ion binding, oxidoreductase activity, superoxide dismutase activity		
YJR105W	ADO1	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle [Source:SGD;Acc:S000003866]	purine base metabolic process, purine ribonucleoside salvage	cytoplasm, nucleus	ATP binding, adenosine kinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YJR106W	ECM27	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p [Source:SGD;Acc:S000003867]	fungal-type cell wall organization, transmembrane transport, transport	cellular_component, integral to membrane, membrane	molecular_function		
YJR107W	YJR107W	Putative protein of unknown function; has sequence or structural similarity to lipases [Source:SGD;Acc:S000003868]	biological_process, lipid catabolic process, lipid metabolic process	cellular_component	hydrolase activity, lipase activity, triglyceride lipase activity		
YJR108W	ABM1	Protein of unknown function, required for normal microtubule organization [Source:SGD;Acc:S000003869]	microtubule cytoskeleton organization	cellular_component	molecular_function		
YJR109C	CPA2	Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor [Source:SGD;Acc:S000003870]	arginine biosynthetic process, cellular amino acid biosynthetic process, metabolic process, nitrogen compound metabolic process	carbamoyl-phosphate synthase complex, cytoplasm	ATP binding, carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, carbamoyl-phosphate synthase activity, catalytic activity, ligase activity, metal ion binding, nucleotide binding		
YJR110W	YMR1	Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family [Source:SGD;Acc:S000003871]	dephosphorylation, phosphatidylinositol dephosphorylation	cytoplasm	hydrolase activity, phosphatase activity, phosphatidylinositol-3-phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity		
YJR111C	YJR111C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria [Source:SGD;Acc:S000003872]	biological_process	mitochondrion	molecular_function		
YJR112W	NNF1	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation [Source:SGD;Acc:S000003873]	cell cycle, cell division, chromosome segregation, mitosis	chromosome, centromeric region, condensed chromosome kinetochore, kinetochore, nuclear MIS12/MIND type complex, nucleus, spindle pole	molecular_function		
YJR112W-A	YJR112W-A	Putative protein of unknown function; identified based on homology to <i>Ashbya gossypii</i> [Source:SGD;Acc:S000028513]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YJR113C	RSM7	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein [Source:SGD;Acc:S000003874]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YJR114W	YJR114W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C [Source:SGD;Acc:S000003875]					
YJR115W	YJR115W	Putative protein of unknown function [Source:SGD;Acc:S000003876]	biological_process	cellular_component	molecular_function		
YJR116W	YJR116W	Putative protein of unknown function [Source:SGD;Acc:S000003877]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YJR117W	STE24	Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans [Source:SGD;Acc:S000003878]	CAAX-box protein processing, peptide pheromone maturation, proteolysis, response to pheromone	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrial outer membrane, nuclear inner membrane	hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity		
YJR118C	ILM1	Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth [Source:SGD;Acc:S000003879]	mitochondrial genome maintenance	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YJR119C	JHD2	JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation [Source:SGD;Acc:S000003880]	chromatin modification, histone demethylation, oxidation-reduction process	cytoplasm, nucleus	histone demethylase activity (H3-K4 specific), metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, protein binding, zinc ion binding		
YJR120W	YJR120W	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p [Source:SGD;Acc:S000003881]	cellular respiration, mitochondrion organization, sterol transport	cellular_component	molecular_function		
YJR121W	ATP2	Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [Source:SGD;Acc:S000003882]	ATP biosynthetic process, ATP hydrolysis coupled proton transport, ATP metabolic process, ATP synthesis coupled proton transport, ion transport, proton transport, transport	membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase, catalytic core, mitochondrion, proton-transporting ATP synthase complex, catalytic core F(1), proton-transporting two-sector ATPase complex, proton-transporting two-sector ATPase complex, catalytic domain	ATP binding, ATPase activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrogen-exporting ATPase activity, phosphorylative mechanism, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding, proton-transporting ATPase activity, rotational mechanism		
YJR122W	IBA57	Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system [Source:SGD;Acc:S000003883]	iron-sulfur cluster assembly	mitochondrial matrix, mitochondrion	molecular_function, transferase activity		
YJR123W	RPS5	Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins [Source:SGD;Acc:S000003884]	rRNA export from nucleus, regulation of translational fidelity, translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome, small ribosomal subunit	RNA binding, structural constituent of ribosome		
YJR124C	YJR124C	Putative protein of unknown function; expression induced under calcium shortage [Source:SGD;Acc:S000003885]	biological_process, transmembrane transport	cellular_component, integral to membrane, membrane	ATP binding, molecular_function, nucleotide binding		
YJR125C	ENT3	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p [Source:SGD;Acc:S000003886]	Golgi to endosome transport, actin cortical patch assembly, actin filament organization, early endosome to Golgi transport, endocytosis, late endosome to vacuole transport via multivesicular body sorting pathway, protein transport, transport	Golgi apparatus, actin cortical patch, clathrin coated vesicle membrane, clathrin vesicle coat, cytoplasm, cytoplasmic vesicle, membrane	lipid binding, protein binding		
YJR126C	VPS70	Protein of unknown function involved in vacuolar protein sorting [Source:SGD;Acc:S000003887]	protein targeting to vacuole, protein transport, proteolysis, transport	cellular_component, integral to membrane, membrane	aminopeptidase activity, hydrolase activity, metal ion binding, metallopeptidase activity, molecular_function, peptidase activity		
YJR127C	RSF2	Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions [Source:SGD;Acc:S000003888]		intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YJR128W	YJR128W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 [Source:SGD;Acc:S000003889]					
YJR129C	YJR129C	Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003890]	biological_process	cytoplasm	S-adenosylmethionine-dependent methyltransferase activity		
YJR130C	STR2	Cystathionine gamma-synthase, converts cysteine into cystathionine [Source:SGD;Acc:S000003891]	cellular amino acid biosynthetic process, cellular amino acid metabolic process, methionine biosynthetic process, sulfur compound metabolic process, transsulfuration	cytoplasm, nucleus	catalytic activity, cystathionine gamma-synthase activity, pyridoxal phosphate binding, transferase activity		
YJR131W	MNS1	Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane [Source:SGD;Acc:S000003892]	ER-associated protein catabolic process, metabolic process, protein N-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	calcium ion binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity		
YJR132W	NMD5	Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog [Source:SGD;Acc:S000003893]	intracellular protein transport, protein import into nucleus, protein transport, transport	cytoplasm, nucleus	binding, protein transporter activity		
YJR133W	XPT1	Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine [Source:SGD;Acc:S000003894]	XMP salvage, hypoxanthine metabolic process, nucleoside metabolic process, purine nucleotide biosynthetic process	cytoplasm	hypoxanthine phosphoribosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups, xanthine phosphoribosyltransferase activity		
YJR134C	SGM1	Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus [Source:SGD;Acc:S000003895]	biological_process	COPI-coated vesicle, Golgi apparatus	molecular_function		
YJR135C	MCM22	Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner [Source:SGD;Acc:S000003896]	cell cycle, cell division, chromosome segregation, establishment of mitotic sister chromatid cohesion, meiosis, mitosis	chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, kinetochore, nucleus	molecular_function		
YJR135W-A	TIM8	Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome [Source:SGD;Acc:S000007348]	protein import into mitochondrial inner membrane, protein targeting to mitochondrion, protein transport, transmembrane transport, transport	membrane, mitochondrial inner membrane, mitochondrial intermembrane space protein transporter complex, mitochondrion	metal ion binding, protein transporter activity		
YJR136C	TTI2	Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003897]	biological_process, chromatin modification	ASTRA complex, cytoplasm, nucleus	molecular_function		
YJR137C	MET5	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine [Source:SGD;Acc:S000003898]	cellular amino acid biosynthetic process, cysteine biosynthetic process, fungal-type cell wall organization, metabolic process, methionine biosynthetic process, oxidation-reduction process, sulfate assimilation	cytoplasm, sulfite reductase complex (NADPH)	4 iron, 4 sulfur cluster binding, FMN binding, catalytic activity, heme binding, iron ion binding, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, sulfite reductase (NADPH) activity		
YJR138W	IML1	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane [Source:SGD;Acc:S000003899]	biological_process, intracellular signal transduction	fungal-type vacuole membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YJR139C	HOM6	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions [Source:SGD;Acc:S000003900]	branched chain family amino acid biosynthetic process, cellular amino acid biosynthetic process, cellular amino acid metabolic process, homoserine biosynthetic process, isoleucine biosynthetic process, metabolic process, methionine biosynthetic process, methionine metabolic process, oxidation-reduction process, threonine biosynthetic process, threonine metabolic process	cytoplasm, nucleus	NADP binding, binding, catalytic activity, homoserine dehydrogenase activity, oxidoreductase activity		
YJR140C	HIR3	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly [Source:SGD;Acc:S000003901]	DNA replication-independent nucleosome assembly, regulation of transcription involved in G1/S phase of mitotic cell cycle, transcription elongation from RNA polymerase II promoter	HIR complex, nucleus	DNA binding, nucleosome binding, transcription corepressor activity		
YJR140W-A	YJR140W-A	Dubious open reading frame; completely overlaps the verified gene HIR3; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028666]					
YJR141W	YJR141W	Essential protein of unknown function [Source:SGD;Acc:S000003902]	biological_process	cellular_component	molecular_function		
YJR142W	YJR142W	Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition [Source:SGD;Acc:S000003903]	biological_process	cellular_component	hydrolase activity, molecular_function		
YJR143C	PMT4	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals [Source:SGD;Acc:S000003904]	protein O-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YJR144W	MGM101	Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage [Source:SGD;Acc:S000003905]	DNA repair, mitochondrial genome maintenance, response to DNA damage stimulus	mitochondrial chromosome, mitochondrial nucleoid, mitochondrion	DNA binding		
YJR145C	RPS4A	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein [Source:SGD;Acc:S000003906]	translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YJR146W	YJR146W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2 [Source:SGD;Acc:S000003907]					
YJR147W	HMS2	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant [Source:SGD;Acc:S000003908]	pseudohyphal growth, regulation of transcription, DNA-dependent	cytoplasm, nucleus	DNA binding, molecular_function, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YJR148W	BAT2	Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase [Source:SGD;Acc:S000003909]	branched chain family amino acid biosynthetic process, branched chain family amino acid catabolic process, branched chain family amino acid metabolic process, cellular amino acid biosynthetic process, metabolic process	cytoplasm, nucleus	branched-chain-amino-acid transaminase activity, catalytic activity, transaminase activity, transferase activity		
YJR149W	YJR149W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003910]	biological_process, metabolic process, oxidation-reduction process	cytoplasm	catalytic activity, molecular_function, monooxygenase activity, nitronate monooxygenase activity, oxidoreductase activity		
YJR150C	DAN1	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth [Source:SGD;Acc:S000003911]	response to stress, sterol transport	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YJR151C	DAN4	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth [Source:SGD;Acc:S000003912]	biological_process, response to stress	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YJR151W-A	YJR151W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational "guilt by association" analysis [Source:SGD;Acc:S000028557]	biological_process	cellular_component	molecular_function		
YJR152W	DAL5	Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression [Source:SGD;Acc:S000003913]	allantoate transport, dipeptide transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	allantoate transmembrane transporter activity, dipeptide transporter activity, transporter activity		
YJR153W	PGU1	Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins [Source:SGD;Acc:S000003914]	carbohydrate metabolic process, cellular cell wall organization, metabolic process, pectin catabolic process, pseudohyphal growth	extracellular region	hydrolase activity, hydrolase activity, acting on glycosyl bonds, polygalacturonase activity		
YJR154W	YJR154W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003915]	biological_process	cytoplasm	molecular_function		
YJR155W	AAD10	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role [Source:SGD;Acc:S000003916]	cellular aldehyde metabolic process, oxidation-reduction process	cellular_component	aryl-alcohol dehydrogenase activity, oxidoreductase activity		
YJR156C	THI11	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 [Source:SGD;Acc:S000003917]	thiamine biosynthetic process	cellular_component	protein binding		
YJR157W	YJR157W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003918]					
YJR158W	HXT16	Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose [Source:SGD;Acc:S000003919]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	fructose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YJR159W	SOR1	Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose [Source:SGD;Acc:S000003920]	hexose metabolic process, metabolic process, oxidation-reduction process	cellular_component	L-iditol 2-dehydrogenase activity, binding, catalytic activity, metal ion binding, oxidoreductase activity, zinc ion binding		
YJR160C	MPH3	Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication [Source:SGD;Acc:S000003921]	carbohydrate transport, maltose metabolic process, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	carbohydrate transmembrane transporter activity, maltose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YJR161C	COS5	Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000003922]	biological_process	fungal-type vacuole, integral to membrane, membrane	molecular_function		
YJR162C	YJR162C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003923]					
YKL001C	MET14	Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism [Source:SGD;Acc:S000001484]	cellular amino acid biosynthetic process, cysteine biosynthetic process, methionine biosynthetic process, methionine metabolic process, sulfate assimilation	cytoplasm, intracellular	ATP binding, adenylylsulfate kinase activity, kinase activity, nucleotide binding, transferase activity, transferase activity, transferring phosphorus-containing groups		
YKL002W	DID4	Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis [Source:SGD;Acc:S000001485]	intralumenal vesicle formation, late endosome to vacuole transport, protein retention in Golgi apparatus, protein transport, transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ESCRT III complex, cytoplasm, endosome, endosome membrane, membrane	molecular_function		
YKL003C	MRP17	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator [Source:SGD;Acc:S000001486]	mitochondrial translation, translation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	rRNA binding, structural constituent of ribosome		
YKL004W	AUR1	Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance [Source:SGD;Acc:S000001487]	inositol phosphorylceramide metabolic process, lipid metabolic process, sphingolipid biosynthetic process, sphingolipid metabolic process	Golgi apparatus, Golgi cisterna membrane, inositol phosphoceramide synthase complex, integral to membrane, membrane	catalytic activity, inositol phosphoceramide synthase activity, transferase activity		
YKL005C	BYE1	Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit [Source:SGD;Acc:S000001488]	negative regulation of transcription from RNA polymerase II promoter	nucleus	metal ion binding, methylated histone residue binding, protein binding, zinc ion binding		
YKL006C-A	SFT1	Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment [Source:SGD;Acc:S000002101]	intra-Golgi vesicle-mediated transport, protein transport, transport, vesicle fusion	Golgi apparatus, Golgi membrane, SNARE complex, integral to membrane, membrane	SNAP receptor activity, protein binding		
YKL006W	RPL14A	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth [Source:SGD;Acc:S000001489]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YKL007W	CAP1	Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches [Source:SGD;Acc:S000001490]	actin cytoskeleton organization, actin filament capping, barbed-end actin filament capping	F-actin capping protein complex, actin cortical patch, actin filament, mating projection tip	actin binding, actin filament binding		
YKL008C	LAC1	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p [Source:SGD;Acc:S000001491]	ceramide biosynthetic process, lipid biosynthetic process, lipid metabolic process, replicative cell aging	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	sphingosine N-acyltransferase activity, transferase activity		
YKL009W	MRT4	Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus [Source:SGD;Acc:S000001492]	nuclear-transcribed mRNA catabolic process, rRNA processing, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis	intracellular, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor	LSU rRNA binding		
YKL010C	UFD4	Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins [Source:SGD;Acc:S000001493]	protein modification process, protein monoubiquitination, protein polyubiquitination	cytoplasm, intracellular, mitochondrion	acid-amino acid ligase activity, binding, ligase activity, ubiquitin-protein ligase activity		
YKL011C	CCE1	Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA [Source:SGD;Acc:S000001494]	mitochondrial genome maintenance	mitochondrial inner membrane, mitochondrion	endodeoxyribonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding		
YKL012W	PRP40	U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex [Source:SGD;Acc:S000001495]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, nucleus, ribonucleoprotein complex	RNA binding, protein binding		
YKL013C	ARC19	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches [Source:SGD;Acc:S000001496]	actin cortical patch assembly, actin filament polymerization, mitochondrion inheritance	Arp2/3 protein complex, actin cortical patch, cytoplasm, cytoskeleton	actin binding, structural molecule activity		
YKL014C	URB1	Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit [Source:SGD;Acc:S000001497]	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus	molecular_function		
YKL015W	PUT3	Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain [Source:SGD;Acc:S000001498]	positive regulation of transcription from RNA polymerase II promoter, proline catabolic process, proline metabolic process, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YKL016C	ATP7	Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis [Source:SGD;Acc:S000001499]	ATP biosynthetic process, ATP synthesis coupled proton transport, ion transport, protein complex assembly, proton transport, transport	membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase complex, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrial proton-transporting ATP synthase, stator stalk, mitochondrion, proton-transporting ATP synthase complex, coupling factor F(o)	ATPase activity, hydrogen ion transmembrane transporter activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism		
YKL017C	HCS1	Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities [Source:SGD;Acc:S000001500]	lagging strand elongation	DNA helicase A complex, alpha DNA polymerase:primase complex, cytoplasm, nucleus	ATP binding, ATP-dependent 5'-3' DNA helicase activity, DNA binding, helicase activity, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding		
YKL018C-A	YKL018C-A	Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000007615]	biological_process	cytoplasm	molecular_function		
YKL018W	SWD2	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination [Source:SGD;Acc:S000001501]	histone H3-K4 methylation, histone H3-K79 methylation, mRNA 3'-end processing, mRNA processing, snoRNA 3'-end processing, telomere maintenance, termination of RNA polymerase II transcription, exosome-dependent, termination of RNA polymerase II transcription, poly(A)-coupled	Set1C/COMPASS complex, chromosome, telomeric region, mRNA cleavage and polyadenylation specificity factor complex, nucleus	histone methyltransferase activity (H3-K4 specific), protein binding		
YKL019W	RAM2	Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor [Source:SGD;Acc:S000001502]	peptide pheromone maturation, protein farnesylation, protein geranylgeranylation, protein prenylation	CAAX-protein geranylgeranyltransferase complex, protein farnesyltransferase complex	CAAX-protein geranylgeranyltransferase activity, prenyltransferase activity, protein farnesyltransferase activity, protein geranylgeranyltransferase activity, protein prenyltransferase activity, transferase activity		
YKL020C	SPT23	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting [Source:SGD;Acc:S000001503]	fatty acid metabolic process, positive regulation of transcription from RNA polymerase II promoter, response to cold	integral to endoplasmic reticulum membrane, nucleus	DNA binding, protein binding		
YKL021C	MAK11	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats [Source:SGD;Acc:S000001504]	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis	membrane, membrane fraction, nuclear membrane, nucleolus, nucleus	molecular_function, protein binding		
YKL022C	CDC16	Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation [Source:SGD;Acc:S000001505]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, cyclin catabolic process, mitosis, mitotic cell cycle, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, negative regulation of DNA-dependent DNA replication initiation, protein ubiquitination	anaphase-promoting complex, nucleus	binding, protein binding, ubiquitin-protein ligase activity		
YKL023C-A	YKL023C-A	Putative protein of unknown function [Source:SGD;Acc:S000113559]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YKL023W	YKL023W	Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001506]	biological_process	cytoplasm	molecular_function		
YKL024C	URA6	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) [Source:SGD;Acc:S000001507]	'de novo' pyrimidine base biosynthetic process, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, pyrimidine nucleotide biosynthetic process	cytoplasm, nucleus	ATP binding, adenylate kinase activity, kinase activity, nucleobase, nucleoside, nucleotide kinase activity, nucleotide binding, nucleotide kinase activity, phosphotransferase activity, phosphate group as acceptor, transferase activity, uridylate kinase activity		
YKL025C	PAN3	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes [Source:SGD;Acc:S000001508]	DNA repair, mRNA 3'-end processing, mRNA processing, postreplication repair, protein phosphorylation	PAN complex, cytoplasm	ATP binding, metal ion binding, nucleic acid binding, nucleotide binding, poly(A)-specific ribonuclease activity, protein kinase activity, zinc ion binding		
YKL026C	GPX1	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress [Source:SGD;Acc:S000001509]	cellular response to oxidative stress, oxidation-reduction process, response to oxidative stress	cellular_component	glutathione peroxidase activity, oxidoreductase activity, peroxidase activity, phospholipid-hydroperoxide glutathione peroxidase activity		
YKL027W	YKL027W	Protein of unknown function, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000001510]	biological_process, metabolic process	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	binding, catalytic activity, molecular_function		
YKL028W	TFA1	TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening [Source:SGD;Acc:S000001511]	transcription initiation from RNA polymerase II promoter	mitochondrion, nucleus, transcription factor TFIIE complex	metal ion binding, zinc ion binding		
YKL029C	MAE1	Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids [Source:SGD;Acc:S000001512]	cellular amino acid metabolic process, malate metabolic process, metabolic process, oxidation-reduction process, pyruvate metabolic process	mitochondrial matrix, mitochondrion	NAD binding, binding, catalytic activity, malate dehydrogenase (oxaloacetate-decarboxylating) activity, malic enzyme activity, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YKL030W	YKL030W	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1 [Source:SGD;Acc:S000001513]					
YKL031W	YKL031W	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species [Source:SGD;Acc:S000001514]					
YKL032C	IXR1	Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b [Source:SGD;Acc:S000001515]	DNA repair, cellular response to hypoxia	nuclear chromatin, nucleus	DNA binding, damaged DNA binding, protein binding, sequence-specific DNA binding		
YKL033W	TTI1	Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001516]	biological_process, chromatin modification	ASTRA complex, cytoplasm, mitochondrion, nucleus	binding, molecular_function		
YKL033W-A	YKL033W-A	Putative protein of unknown function; similar to uncharacterized proteins from other fungi [Source:SGD;Acc:S000007242]	biological_process, metabolic process	cellular_component	catalytic activity, hydrolase activity, molecular_function		
YKL034W	TUL1	Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes [Source:SGD;Acc:S000001517]	protein ubiquitination, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	Golgi apparatus, Golgi membrane, integral to membrane, membrane	ligase activity, metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YKL035W	UGP1	UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p [Source:SGD;Acc:S000001518]	1,6-beta-glucan biosynthetic process, UDP-glucose metabolic process, glycogen biosynthetic process, metabolic process, trehalose biosynthetic process	cytoplasm, plasma membrane enriched fraction	UTP:glucose-1-phosphate uridylyltransferase activity, metal ion binding, nucleotidyltransferase activity, transferase activity		
YKL036C	YKL036C	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W [Source:SGD;Acc:S000001519]					
YKL037W	AIM26	Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT [Source:SGD;Acc:S000001520]	autophagy, mitochondrion degradation	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YKL038W	RGT1	Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor [Source:SGD;Acc:S000001521]	glucose metabolic process, regulation of glucose import, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, transcription corepressor activity, zinc ion binding		
YKL039W	PTM1	Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p [Source:SGD;Acc:S000001522]	biological_process	Golgi apparatus, Golgi membrane, cellular_component, early endosome membrane, endosome, integral to membrane, membrane	molecular_function		
YKL040C	NFU1	Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria [Source:SGD;Acc:S000001523]	cellular iron ion homeostasis, intracellular sequestering of iron ion, iron-sulfur cluster assembly	mitochondrial matrix, mitochondrion	iron ion binding, iron-sulfur cluster binding, molecular_function		
YKL041W	VPS24	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway [Source:SGD;Acc:S000001524]	intralumenal vesicle formation, late endosome to vacuole transport, protein transport, transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ESCRT III complex, cytoplasm, endomembrane system, endosome, endosome membrane, membrane			
YKL042W	SPC42	Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane [Source:SGD;Acc:S000001525]	microtubule nucleation, spindle pole body duplication in nuclear envelope	central plaque of spindle pole body, intermediate layer of spindle pole body, nucleus	structural constituent of cytoskeleton		
YKL043W	PHD1	Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate [Source:SGD;Acc:S000001526]	positive regulation of transcription from RNA polymerase II promoter, pseudohyphal growth, regulation of transcription, DNA-dependent	nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YKL044W	YKL044W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001527]					
YKL045W	PRI2	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair [Source:SGD;Acc:S000001528]	DNA replication, DNA replication, synthesis of RNA primer, DNA synthesis involved in DNA repair, DNA-dependent DNA replication initiation, lagging strand elongation	alpha DNA polymerase:primase complex, nuclear envelope, nucleus	4 iron, 4 sulfur cluster binding, DNA binding, DNA primase activity, DNA-directed RNA polymerase activity, iron-sulfur cluster binding, metal ion binding, nucleotidyltransferase activity, single-stranded DNA binding, transferase activity		
YKL046C	DCW1	Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p [Source:SGD;Acc:S000001529]	budding cell bud growth, carbohydrate catabolic process, cellular cell wall organization, fungal-type cell wall biogenesis, metabolic process	anchored to membrane, anchored to plasma membrane, membrane, membrane fraction, plasma membrane	catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, mannan endo-1,6-alpha-mannosidase activity, mannosidase activity		
YKL047W	YKL047W	Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001530]	biological_process	cytoplasm, integral to membrane, membrane	molecular_function		
YKL048C	ELM1	Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring [Source:SGD;Acc:S000001531]	axial cellular bud site selection, budding cell bud growth, cell cycle, cell morphogenesis, cytokinesis, glucose metabolic process, positive regulation of protein autophosphorylation, protein autophosphorylation, protein phosphorylation, pseudohyphal growth, response to drug, response to osmotic stress, septin checkpoint	cellular bud neck contractile ring	ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YKL049C	CSE4	Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p [Source:SGD;Acc:S000001532]	2-micrometer plasmid partitioning, mitotic sister chromatid segregation, nucleosome assembly	centromere-specific nucleosome, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome, centromeric region, extrachromosomal circular DNA, kinetochore, nuclear nucleosome, nucleosome, nucleus	DNA binding, centromeric DNA binding, sequence-specific DNA binding		
YKL050C	YKL050C	Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p [Source:SGD;Acc:S000001533]	biological_process	cellular_component	molecular_function		
YKL051W	SFK1	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane [Source:SGD;Acc:S000001534]	actin cytoskeleton organization, inositol lipid-mediated signaling, lipid biosynthetic process, lipid metabolic process, vacuole organization	integral to membrane, membrane, plasma membrane	molecular_function		
YKL052C	ASK1	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases [Source:SGD;Acc:S000001535]	cell cycle, cell division, chromosome segregation, mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization	DASH complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, condensed nuclear chromosome, centromeric region, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle	microtubule binding, structural constituent of cytoskeleton		
YKL053C-A	MDM35	Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000007243]	mitochondrial respiratory chain complex assembly, mitochondrion organization	cytoplasm, mitochondrial intermembrane space, nucleus	molecular_function		
YKL053W	YKL053W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1 [Source:SGD;Acc:S000001536]					
YKL054C	DEF1	RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis [Source:SGD;Acc:S000001537]	response to DNA damage stimulus, telomere maintenance, transcription-coupled nucleotide-excision repair, ubiquitin-dependent protein catabolic process	nucleus	molecular_function, protein binding		
YKL055C	OAR1	Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p [Source:SGD;Acc:S000001538]	aerobic respiration, fatty acid biosynthetic process, fatty acid metabolic process, lipid biosynthetic process, metabolic process, oxidation-reduction process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity, binding, catalytic activity, oxidoreductase activity		
YKL056C	TMA19	Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress [Source:SGD;Acc:S000001539]	cellular response to oxidative stress, translation	cytoplasm, cytoskeleton, cytosol, microtubule, mitochondrion, ribosome	molecular_function		
YKL057C	NUP120	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p [Source:SGD;Acc:S000001540]	NLS-bearing substrate import into nucleus, chromosome localization, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	Nup107-160 complex, membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YKL058W	TOA2	TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA [Source:SGD;Acc:S000001541]	transcription initiation from RNA polymerase II promoter	nucleus, transcription factor TFIIA complex			
YKL059C	MPE1	Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif [Source:SGD;Acc:S000001542]	mRNA cleavage, mRNA polyadenylation, mRNA processing	mRNA cleavage and polyadenylation specificity factor complex, nucleus	RNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YKL060C	FBA1	Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress [Source:SGD;Acc:S000001543]	gluconeogenesis, glycolysis, metabolic process	cytoplasm, cytosol, mitochondrion	catalytic activity, fructose-bisphosphate aldolase activity, lyase activity, metal ion binding, zinc ion binding		
YKL061W	BLI1	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome [Source:SGD;Acc:S000001544]	biological_process	endosome	molecular_function		
YKL062W	MSN4	Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression [Source:SGD;Acc:S000001545]	age-dependent response to oxidative stress involved in chronological cell aging, cellular response to glucose starvation, cellular response to oxidative stress, heat acclimation, regulation of transcription from RNA polymerase II promoter in response to stress, replicative cell aging, response to freezing, response to hydrostatic pressure, response to osmotic stress, response to stress	cytoplasm, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YKL063C	YKL063C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi [Source:SGD;Acc:S000001546]	biological_process	Golgi apparatus	molecular_function		
YKL064W	MNR2	Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations [Source:SGD;Acc:S000001547]	cellular magnesium ion homeostasis, metal ion transport, transmembrane transport	fungal-type vacuole membrane, integral to membrane, membrane	magnesium ion transmembrane transporter activity, metal ion transmembrane transporter activity		
YKL065C	YET1	Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein [Source:SGD;Acc:S000001548]	biological_process, intracellular protein transport, protein transport, transport, vesicle-mediated transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, ribosome	molecular_function		
YKL065W-A	YKL065W-A	Putative protein of unknown function [Source:SGD;Acc:S000113563]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YKL066W	YKL066W	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1 [Source:SGD;Acc:S000001549]					
YKL067W	YNK1	Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate [Source:SGD;Acc:S000001550]	CTP biosynthetic process, DNA repair, GTP biosynthetic process, UTP biosynthetic process, nucleoside diphosphate phosphorylation, nucleoside triphosphate biosynthetic process, nucleotide metabolic process, response to DNA damage stimulus	cytoplasm, cytosol, mitochondrial intermembrane space, mitochondrion	ATP binding, kinase activity, metal ion binding, nucleoside diphosphate kinase activity, nucleotide binding, transferase activity		
YKL068W	NUP100	Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p [Source:SGD;Acc:S000001551]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YKL068W-A	YKL068W-A	Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i> [Source:SGD;Acc:S000028524]	biological_process	cellular_component	molecular_function		
YKL069W	YKL069W	Methionine-R-sulfoxide reductase, reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress [Source:SGD;Acc:S000001552]	cellular response to oxidative stress, oxidation-reduction process, response to stress	cytoplasm, nucleus	L-methionine-(R)-S-oxide reductase activity, methionine-R-sulfoxide reductase activity, oxidoreductase activity, protein binding		
YKL070W	YKL070W	Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001553]	biological_process	mitochondrion	FMN binding, molecular_function		
YKL071W	YKL071W	Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001554]	biological_process, metabolic process, oxidation-reduction process	cytoplasm	binding, catalytic activity, molecular_function, oxidoreductase activity		
YKL072W	STB6	Protein that binds Sin3p in a two-hybrid assay [Source:SGD;Acc:S000001555]	biological_process	cellular_component	molecular_function		
YKL073W	LHS1	Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway [Source:SGD;Acc:S000001556]	posttranslational protein targeting to membrane, translocation, response to unfolded protein	endoplasmic reticulum, endoplasmic reticulum lumen	ATP binding, ATPase activity, uncoupled, adenyl-nucleotide exchange factor activity, hydrolase activity, nucleotide binding, unfolded protein binding		
YKL074C	MUD2	Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65 [Source:SGD;Acc:S000001557]	RNA splicing, mRNA processing, nuclear mRNA branch site recognition	commitment complex	RNA binding, nucleic acid binding, nucleotide binding, pre-mRNA branch point binding		
YKL075C	YKL075C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin [Source:SGD;Acc:S000001558]	response to drug	cytoplasm	molecular_function		
YKL076C	PSY1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C [Source:SGD;Acc:S000001559]					
YKL077W	YKL077W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole [Source:SGD;Acc:S000001560]	biological_process	fungal-type vacuole	molecular_function		
YKL078W	DHR2	Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis [Source:SGD;Acc:S000001561]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus	ATP binding, ATP-dependent helicase activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YKL079W	SMY1	Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins [Source:SGD;Acc:S000001562]	exocytosis, microtubule-based movement	cellular bud neck, cellular bud tip, cytoplasm, cytoskeleton, incipient cellular bud site, mating projection tip, microtubule	ATP binding, microtubule motor activity, motor activity, nucleotide binding		
YKL080W	VMA5	Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane [Source:SGD;Acc:S000001563]	ATP synthesis coupled proton transport, ion transport, proton transport, transport, vacuolar acidification	fungal-type vacuole membrane, membrane, proton-transporting V-type ATPase, V1 domain, vacuolar membrane, vacuolar proton-transporting V-type ATPase, V1 domain, vacuole	ATP binding, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, nucleotide binding, proton-transporting ATPase activity, rotational mechanism		
YKL081W	TEF4	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex [Source:SGD;Acc:S000001564]	translation, translational elongation	cytoplasm, eukaryotic translation elongation factor 1 complex, mitochondrion, ribosome	translation elongation factor activity		
YKL082C	RRP14	Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family [Source:SGD;Acc:S000001565]	rRNA processing, ribosomal large subunit biogenesis, ribosomal small subunit biogenesis, ribosome biogenesis	cytosolic large ribosomal subunit, nucleolus, nucleus	molecular_function		
YKL083W	YKL083W	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene RRP14 [Source:SGD;Acc:S000001566]					
YKL084W	HOT13	Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc [Source:SGD;Acc:S000001567]	protein import into mitochondrial intermembrane space, protein transport, transmembrane transport, transport	membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion	metal ion binding, zinc ion binding		
YKL085W	MDH1	Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated [Source:SGD;Acc:S000001568]	aerobic respiration, carbohydrate metabolic process, cellular carbohydrate metabolic process, chronological cell aging, glycolysis, malate metabolic process, metabolic process, oxidation-reduction process, replicative cell aging, tricarboxylic acid cycle	mitochondrial matrix, mitochondrion	L-malate dehydrogenase activity, binding, catalytic activity, malate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YKL086W	SRX1	Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes [Source:SGD;Acc:S000001569]	cellular response to oxidative stress, oxidation-reduction process	cytoplasm, nucleus	ATP binding, DNA binding, antioxidant activity, nucleotide binding, oxidoreductase activity, sulfiredoxin activity		
YKL087C	CYT2	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 [Source:SGD;Acc:S000001570]	cytochrome c-heme linkage	membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion	holocytochrome-c synthase activity, lyase activity, metal ion binding		
YKL088W	CAB3	Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC [Source:SGD;Acc:S000001571]	coenzyme A biosynthetic process, response to salt stress	cytoplasm, phosphopantothenoylcysteine decarboxylase complex	catalytic activity, phosphopantothenoylcysteine decarboxylase activity, purine nucleotide binding		
YKL089W	MIF2	Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p [Source:SGD;Acc:S000001572]	cell cycle, cell division, chromosome segregation, mitosis, mitotic spindle organization in nucleus	chromosome, centromeric region, condensed nuclear chromosome kinetochore, nucleus	DNA binding, centromeric DNA binding		
YKL090W	CUE2	Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination [Source:SGD;Acc:S000001573]	biological_process	cellular_component	protein binding, ubiquitin binding		
YKL091C	YKL091C	Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus [Source:SGD;Acc:S000001574]	biological_process	nucleus	molecular_function		
YKL092C	BUD2	GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types [Source:SGD;Acc:S000001575]	axial cellular bud site selection, bipolar cellular bud site selection, cellular bud site selection, filamentous growth, regulation of small GTPase mediated signal transduction, signal transduction, small GTPase mediated signal transduction	intracellular	GTPase activator activity, Ras GTPase activator activity, protein binding		
YKL093W	MBR1	Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants [Source:SGD;Acc:S000001576]	aerobic respiration	cellular_component, mitochondrion	molecular_function		
YKL094W	YJU3	Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family [Source:SGD;Acc:S000001577]	triglyceride metabolic process	cytoplasm, endoplasmic reticulum, lipid particle, membrane, mitochondrial outer membrane, mitochondrion, plasma membrane enriched fraction	acylglycerol lipase activity, hydrolase activity, serine hydrolase activity		
YKL095W	YJU2	Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ("nineteen complex") and acts after Prp2p to promote the first catalytic reaction of splicing [Source:SGD;Acc:S000001578]	generation of catalytic spliceosome for first transesterification step	U2-type catalytic step 1 spliceosome, nucleus	first spliceosomal transesterification activity		
YKL096C-B	YKL096C-B	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028667]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YKL096W	CWP1	Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance [Source:SGD;Acc:S000001579]	ascospore-type prospore membrane assembly, fungal-type cell wall organization	anchored to membrane, cell wall, cellular birth scar, extracellular region, fungal-type cell wall, membrane, prospore membrane	structural constituent of cell wall		
YKL096W-A	CWP2	Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored [Source:SGD;Acc:S000001956]	fungal-type cell wall organization, regulation of pH	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	structural constituent of cell wall		
YKL097C	YKL097C	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species [Source:SGD;Acc:S000001580]					
YKL098W	MTC2	Protein of unknown function; mtc2 is synthetically sick with cdc13-1 [Source:SGD;Acc:S000001581]	biological_process	cellular_component	molecular_function		
YKL099C	UTP11	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit [Source:SGD;Acc:S000001582]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	molecular_function		
YKL100C	YKL100C	Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene [Source:SGD;Acc:S000001583]	biological_process	cellular_component, integral to membrane, membrane	aspartic-type endopeptidase activity, hydrolase activity, molecular_function, peptidase activity		
YKL100W-A	YKL100W-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028840]					
YKL101W	HSL1	Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p [Source:SGD;Acc:S000001584]	G2/M transition of mitotic cell cycle, cell shape checkpoint, protein autophosphorylation, protein phosphorylation, regulation of cell cycle, septin checkpoint	cellular bud neck, septin ring	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YKL102C	YKL102C	Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site [Source:SGD;Acc:S000001585]					
YKL103C	LAP4	Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway [Source:SGD;Acc:S000001586]	proteolysis, vacuolar protein catabolic process	fungal-type vacuole, vacuole	aminopeptidase activity, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding		
YKL104C	GFA1	Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis [Source:SGD;Acc:S000001587]	carbohydrate biosynthetic process, carbohydrate metabolic process, fungal-type cell wall chitin biosynthetic process, glutamine metabolic process, metabolic process	cellular_component, cytoplasm	glutamine-fructose-6-phosphate transaminase (isomerizing) activity, sugar binding, transaminase activity, transferase activity		
YKL105C	YKL105C	Putative protein of unknown function [Source:SGD;Acc:S000001588]	biological_process	cellular_component	molecular_function		
YKL106C-A	YKL106C-A	Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi [Source:SGD;Acc:S000007616]	biological_process	cellular_component	molecular_function		
YKL106W	AAT1	Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis [Source:SGD;Acc:S000001589]	asparagine biosynthetic process from oxaloacetate, aspartate biosynthetic process, aspartate catabolic process, biosynthetic process, cellular amino acid metabolic process, chronological cell aging, replicative cell aging	mitochondrial matrix, mitochondrion	L-aspartate:2-oxoglutarate aminotransferase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity, transferase activity, transferring nitrogenous groups		
YKL107W	YKL107W	Putative protein of unknown function; proposed to be a palmitoylated membrane protein [Source:SGD;Acc:S000001590]	biological_process, metabolic process, oxidation-reduction process	cellular_component, integral to membrane, membrane	binding, catalytic activity, molecular_function, oxidoreductase activity		
YKL108W	SLD2	Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate [Source:SGD;Acc:S000001591]	DNA replication, DNA strand elongation involved in DNA replication, cell cycle, double-strand break repair via break-induced replication	DNA replication preinitiation complex, nucleus, replication fork	molecular_function		
YKL109W	HAP4	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex [Source:SGD;Acc:S000001592]	regulation of carbohydrate metabolic process, regulation of transcription, DNA-dependent	CCAAT-binding factor complex, nucleus	DNA binding		
YKL110C	KTI12	Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p [Source:SGD;Acc:S000001593]	cell growth, regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification	cytoplasm, nucleus	ATP binding, chromatin binding, nucleotide binding		
YKL111C	YKL111C	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene ABF1 [Source:SGD;Acc:S000001594]					
YKL112W	ABF1	DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair [Source:SGD;Acc:S000001595]	DNA replication, chromatin remodeling, chromatin silencing at silent mating-type cassette, negative regulation of transcription from RNA polymerase II promoter, nucleotide-excision repair, DNA damage recognition, positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin, nucleotide-excision repair factor 4 complex, nucleus	DNA bending activity, DNA binding, DNA replication origin binding, chromatin binding, metal ion binding, sequence-specific DNA binding		
YKL113C	RAD27	5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family [Source:SGD;Acc:S000001596]	DNA repair, DNA replication, DNA replication, removal of RNA primer, base-excision repair, base-free sugar-phosphate removal, double-strand break repair via nonhomologous end joining, gene conversion at mating-type locus, DNA repair synthesis, replicative cell aging, response to DNA damage stimulus	mitochondrion, nucleolus, nucleoplasm, nucleus	5'-3' exonuclease activity, 5'-flap endonuclease activity, DNA binding, catalytic activity, endonuclease activity, exonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding, nuclease activity		
YKL114C	APN1	Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine [Source:SGD;Acc:S000001597]	DNA repair, base-excision repair, response to DNA damage stimulus	intracellular, mitochondrion, nucleus	3'-tyrosyl-DNA phosphodiesterase activity, DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity, deoxyribonuclease IV (phage-T4-induced) activity, double-stranded DNA specific 3'-5' exodeoxyribonuclease activity, endonuclease activity, lyase activity, metal ion binding, phosphoric diester hydrolase activity, zinc ion binding		
YKL115C	YKL115C	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 [Source:SGD;Acc:S000001598]					
YKL116C	PRR1	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor [Source:SGD;Acc:S000001599]	negative regulation of conjugation with cellular fusion, negative regulation of transcription from RNA polymerase II promoter by pheromones, protein phosphorylation	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, receptor signaling protein serine/threonine kinase activity, transferase activity		
YKL117W	SBA1	Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity [Source:SGD;Acc:S000001600]	positive regulation of telomere maintenance via telomerase, protein folding, regulation of telomerase activity	cytoplasm, nucleus	chaperone binding		
YKL118W	YKL118W	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 [Source:SGD;Acc:S000001601]					
YKL119C	VPH2	Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) [Source:SGD;Acc:S000001602]	vacuolar acidification, vacuolar proton-transporting V-type ATPase complex assembly	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YKL120W	OAC1	Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family [Source:SGD;Acc:S000001603]	isopropylmalate transport, oxaloacetate transport, sulfate transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, isopropylmalate transmembrane transporter activity, oxaloacetate secondary active transmembrane transporter activity, secondary active sulfate transmembrane transporter activity		
YKL121W	DGR2	Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds [Source:SGD;Acc:S000001604]	biological_process	cellular_component	molecular_function, protein binding		
YKL122C	SRP21	Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm [Source:SGD;Acc:S000001605]	SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, negative regulation of translational elongation, protein targeting to ER	cytoplasm, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting	7S RNA binding, RNA binding, signal sequence binding		
YKL123W	YKL123W	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4 [Source:SGD;Acc:S000001606]					
YKL124W	SSH4	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases [Source:SGD;Acc:S000001607]	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, protein transport, transport, vesicle-mediated transport	endosome, endosome membrane, fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YKL125W	RRN3	Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA [Source:SGD;Acc:S000001608]	transcription from RNA polymerase I promoter, transcription of nuclear rRNA large RNA polymerase I transcript	RNA polymerase I transcription factor complex, nucleolus, nucleus	binding		
YKL126W	YPK1	Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK [Source:SGD;Acc:S000001609]	cellular cell wall organization, eisosome assembly, endocytosis, negative regulation of phospholipid translocation, protein autophosphorylation, protein phosphorylation	cellular bud neck, cytoplasm, cytosol, membrane, plasma membrane	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YKL127W	PGM1	Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism [Source:SGD;Acc:S000001610]	UDP-glucose metabolic process, carbohydrate metabolic process, galactose catabolic process, glucose 1-phosphate metabolic process, glucose 6-phosphate metabolic process, glucose metabolic process, glycogen biosynthetic process, trehalose biosynthetic process	cytoplasm	intramolecular transferase activity, phosphotransferases, isomerase activity, magnesium ion binding, metal ion binding, phosphoglucomutase activity		
YKL128C	PMU1	Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant [Source:SGD;Acc:S000001611]	biological_process	cytoplasm, nucleus	isomerase activity, molecular_function		
YKL129C	MYO3	One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization [Source:SGD;Acc:S000001612]	actin cortical patch localization, bipolar cellular bud site selection, endocytosis, exocytosis, fungal-type cell wall organization, response to osmotic stress	actin cortical patch, cytoplasm, cytoskeleton, myosin complex	ATP binding, actin binding, hydrolase activity, microfilament motor activity, motor activity, nucleotide binding		
YKL130C	SHE2	RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud [Source:SGD;Acc:S000001613]	intracellular mRNA localization, mating type switching	cellular bud tip, cytoplasm	mRNA binding		
YKL131W	YKL131W	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001614]					
YKL132C	RMA1	Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001615]	biological_process, biosynthetic process, folic acid-containing compound biosynthetic process, one-carbon metabolic process	mitochondrion	ATP binding, ligase activity, nucleotide binding, tetrahydrofolylpolyglutamate synthase activity		
YKL133C	YKL133C	Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype) [Source:SGD;Acc:S000001616]	biological_process	cellular_component, integral to membrane, membrane	binding, molecular_function		
YKL134C	OCT1	Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis [Source:SGD;Acc:S000001617]	cellular iron ion homeostasis, protein processing involved in protein targeting to mitochondrion, proteolysis	mitochondrial matrix, mitochondrion	hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity		
YKL135C	APL2	Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting [Source:SGD;Acc:S000001618]	Golgi to vacuole transport, intracellular protein transport, protein transport, vesicle-mediated transport	AP-1 adaptor complex, coated pit, membrane, membrane coat, plasma membrane	binding, clathrin binding, protein transporter activity		
YKL136W	YKL136W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C [Source:SGD;Acc:S000001619]					
YKL137W	CMC1	Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif [Source:SGD;Acc:S000001620]	mitochondrial respiratory chain complex IV assembly	extrinsic to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion	copper ion binding, metal ion binding		
YKL138C	MRPL31	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000001621]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YKL138C-A	HSK3	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000028421]	cell cycle, cell division, chromosome segregation, mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization	DASH complex, chromosome, centromeric region, condensed chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle	microtubule binding		
YKL139W	CTK1	Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity [Source:SGD;Acc:S000001622]	mRNA 3'-end processing, mRNA processing, peptidyl-serine phosphorylation, phosphorylation of RNA polymerase II C-terminal domain, positive regulation of transcription elongation, DNA-dependent, positive regulation of transcription from RNA polymerase I promoter, positive regulation of translational fidelity, protein phosphorylation, response to DNA damage stimulus, response to stress, translation	carboxy-terminal domain protein kinase complex, cytoplasm, nucleolus, nucleoplasm, nucleus, polysome	ATP binding, RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YKL140W	TGL1	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes [Source:SGD;Acc:S000001623]	cellular lipid metabolic process, lipid catabolic process, lipid metabolic process, sterol metabolic process	integral to membrane, lipid particle, membrane	hydrolase activity, lipase activity, sterol esterase activity		
YKL141W	SDH3	Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain [Source:SGD;Acc:S000001624]	cellular respiration, electron transport chain, mitochondrial electron transport, succinate to ubiquinone, transport, tricarboxylic acid cycle	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex II, mitochondrion, plasma membrane succinate dehydrogenase complex	electron carrier activity, metal ion binding, oxidoreductase activity, acting on the CH-CH group of donors, quinone binding, succinate dehydrogenase (ubiquinone) activity, succinate dehydrogenase activity		
YKL142W	MRP8	Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; originally thought to be a mitochondrial ribosomal protein based on sequence analysis [Source:SGD;Acc:S000001625]	biological_process	cytoplasm	molecular_function		
YKL143W	LTV1	Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature [Source:SGD;Acc:S000001626]	cellular response to oxidative stress, protein transport, response to osmotic stress, ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus, transport	GSE complex, cytoplasm, late endosome membrane, nucleus, preribosome, small subunit precursor	molecular_function		
YKL144C	RPC25	RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p [Source:SGD;Acc:S000001627]	tRNA transcription from RNA polymerase III promoter, transcription initiation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex, nucleus	DNA binding, DNA-directed RNA polymerase activity		
YKL145W	RPT1	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance [Source:SGD;Acc:S000001628]	positive regulation of protein catabolic process, proteasome regulatory particle assembly, protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus, proteasome complex, proteasome regulatory particle, base subcomplex	ATP binding, ATPase activity, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding		
YKL145W-A	YKL145W-A	Dubious open reading frame, unlikely to encode a protein; completely overlaps the verified essential gene RPT1; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028841]					
YKL146W	AVT3	Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000001629]	amino acid export from vacuole, amino acid transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	L-glutamine transmembrane transporter activity, L-isoleucine transmembrane transporter activity, L-tyrosine transmembrane transporter activity, transporter activity		
YKL147C	YKL147C	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3 [Source:SGD;Acc:S000001630]					
YKL148C	SDH1	Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain [Source:SGD;Acc:S000001631]	cellular respiration, electron transport chain, mitochondrial electron transport, succinate to ubiquinone, oxidation-reduction process, transport, tricarboxylic acid cycle	membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrial respiratory chain complex II, mitochondrion	electron carrier activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, succinate dehydrogenase (ubiquinone) activity		
YKL149C	DBR1	RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition [Source:SGD;Acc:S000001632]	RNA catabolic process, mRNA processing, pseudohyphal growth, snoRNA metabolic process, transposition, RNA-mediated	cytoplasm, nucleus	RNA lariat debranching enzyme activity, hydrolase activity, hydrolase activity, acting on ester bonds		
YKL150W	MCR1	Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis [Source:SGD;Acc:S000001633]	cellular response to oxidative stress, ergosterol biosynthetic process, oxidation-reduction process	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial intermembrane space, mitochondrial outer membrane, mitochondrion	cytochrome-b5 reductase activity, oxidoreductase activity		
YKL151C	YKL151C	Putative protein of unknown function; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001634]	biological_process	cytoplasm	molecular_function		
YKL152C	GPM1	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis [Source:SGD;Acc:S000001635]	gluconeogenesis, glycolysis, metabolic process	cytosol, mitochondrion	catalytic activity, intramolecular transferase activity, phosphotransferases, isomerase activity, phosphoglycerate mutase activity		
YKL153W	YKL153W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant [Source:SGD;Acc:S000001636]					
YKL154W	SRP102	Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane [Source:SGD;Acc:S000001637]	SRP-dependent cotranslational protein targeting to membrane, protein targeting to ER	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, ribonucleoprotein complex, signal recognition particle receptor complex	GTP binding, GTPase activity, nucleotide binding, receptor activity, signal recognition particle binding		
YKL155C	RSM22	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase [Source:SGD;Acc:S000001638]	mitochondrial translation, translation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, structural constituent of ribosome, transferase activity		
YKL156C-A	YKL156C-A	Dubious open reading frame unlikely to encode a protein; completely overlaps the verified gene RPS27A; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028668]					
YKL156W	RPS27A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein [Source:SGD;Acc:S000001639]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit assembly, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	metal ion binding, structural constituent of ribosome		
YKL157W	APE2	Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W [Source:SGD;Acc:S000001640]	peptide catabolic process, proteolysis	cell wall-bounded periplasmic space, cytoplasm, extracellular region, mitochondrion, periplasmic space	aminopeptidase activity, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding		
YKL159C	RCN1	Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region [Source:SGD;Acc:S000001642]	calcium-mediated signaling	cytoplasm	calcium-dependent protein serine/threonine phosphatase regulator activity, protein phosphatase 2B binding		
YKL160W	ELF1	Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression [Source:SGD;Acc:S000001643]	chromatin organization, transcription elongation from RNA polymerase II promoter	nucleus	metal ion binding		
YKL161C	KDX1	Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p [Source:SGD;Acc:S000001644]	biological_process, protein phosphorylation	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YKL162C	YKL162C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion [Source:SGD;Acc:S000001645]	biological_process	mitochondrion	molecular_function		
YKL162C-A	YKL162C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007244]					
YKL163W	PIR3	O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway [Source:SGD;Acc:S000001646]	cellular cell wall organization, fungal-type cell wall organization	cell wall, extracellular region, fungal-type cell wall	structural constituent of cell wall		
YKL164C	PIR1	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle [Source:SGD;Acc:S000001647]	cellular cell wall organization, fungal-type cell wall organization, intracellular protein transport	cell wall, extracellular region, fungal-type cell wall	structural constituent of cell wall		
YKL165C	MCD4	Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes [Source:SGD;Acc:S000001648]	ATP transport, GPI anchor biosynthetic process, cellular cell wall organization, metabolic process	Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, fungal-type cell wall, fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	catalytic activity, mannose-ethanolamine phosphotransferase activity, transferase activity		
YKL165C-A	YKL165C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007617]					
YKL166C	TPK3	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase [Source:SGD;Acc:S000001649]	Ras protein signal transduction, mitochondrion organization, protein phosphorylation	cAMP-dependent protein kinase complex, cytoplasm, nucleus	ATP binding, cAMP-dependent protein kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YKL167C	MRP49	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation [Source:SGD;Acc:S000001650]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YKL168C	KKQ8	Putative serine/threonine protein kinase with unknown cellular role [Source:SGD;Acc:S000001651]	biological_process, protein phosphorylation	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YKL169C	YKL169C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38 [Source:SGD;Acc:S000001652]					
YKL170W	MRPL38	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels [Source:SGD;Acc:S000001653]	mitochondrial translation, translation	intracellular, large ribosomal subunit, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YKL171W	NNK1	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm [Source:SGD;Acc:S000001654]	protein phosphorylation, proteolysis	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YKL172W	EBP2	Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles [Source:SGD;Acc:S000001655]	nuclear division, rRNA processing, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor	molecular_function		
YKL173W	SNU114	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 [Source:SGD;Acc:S000001656]	RNA splicing, assembly of spliceosomal tri-snRNP, generation of catalytic spliceosome for first transesterification step, mRNA processing, nuclear mRNA splicing, via spliceosome, spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	U4/U6 x U5 tri-snRNP complex, U5 snRNP, nucleus	GTP binding, GTPase activity, U5 snRNA binding, nucleotide binding		
YKL174C	TPO5	Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles [Source:SGD;Acc:S000001657]	amino acid transport, polyamine transport, transmembrane transport, transport	Golgi apparatus, Golgi membrane, integral to membrane, membrane	amino acid transmembrane transporter activity, polyamine transmembrane transporter activity		
YKL175W	ZRT3	Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency [Source:SGD;Acc:S000001658]	cellular zinc ion homeostasis, ion transport, metal ion transport, transmembrane transport, transport, zinc ion transport	integral to membrane, membrane, vacuolar membrane, vacuole	metal ion transmembrane transporter activity, zinc ion transmembrane transporter activity		
YKL176C	LST4	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface [Source:SGD;Acc:S000001659]	Golgi to plasma membrane transport, amino acid transport, intracellular protein transport, protein transport, transport, vesicle-mediated transport	vesicle coat	protein transporter activity		
YKL177W	YKL177W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3 [Source:SGD;Acc:S000001660]					
YKL178C	STE3	Receptor for a factor pheromone, couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR [Source:SGD;Acc:S000001661]	G-protein coupled receptor protein signaling pathway, cytogamy, pheromone-dependent signal transduction involved in conjugation with cellular fusion, response to pheromone, signal transduction	integral to membrane, integral to plasma membrane, membrane	G-protein coupled receptor activity, mating-type a-factor pheromone receptor activity, mating-type factor pheromone receptor activity, receptor activity, signal transducer activity		
YKL179C	COY1	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function [Source:SGD;Acc:S000001662]	Golgi vesicle transport, intra-Golgi vesicle-mediated transport, transport	Golgi apparatus, Golgi membrane, integral to Golgi membrane, integral to membrane, membrane	molecular_function		
YKL180W	RPL17A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex) [Source:SGD;Acc:S000001663]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, large ribosomal subunit, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YKL181W	PRS1	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [Source:SGD;Acc:S000001664]	5-phosphoribose 1-diphosphate biosynthetic process, cellular biosynthetic process, fungal-type cell wall organization, nucleotide biosynthetic process, ribonucleoside monophosphate biosynthetic process	cytoplasm	ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, ribose phosphate diphosphokinase activity, transferase activity		
YKL182W	FAS1	Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities [Source:SGD;Acc:S000001665]	fatty acid biosynthetic process, lipid biosynthetic process, metabolic process, oxidation-reduction process	cytoplasm, cytosol, fatty acid synthase complex, lipid particle, mitochondrion	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity, [acyl-carrier-protein] S-acetyltransferase activity, [acyl-carrier-protein] S-malonyltransferase activity, catalytic activity, enoyl-[acyl-carrier-protein] reductase (NADH) activity, enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity, fatty acid synthase activity, fatty-acyl-CoA synthase activity, hydrolase activity, lyase activity, oleoyl-[acyl-carrier-protein] hydrolase activity, oxidoreductase activity, palmitoyltransferase activity, transferase activity		
YKL183C-A	YKL183C-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028558]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YKL183W	LOT5	Protein of unknown function; gene expression increases in cultures shifted to a lower temperature [Source:SGD;Acc:S000001666]	biological_process	cytoplasm, nucleus	molecular_function		
YKL184W	SPE1	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation [Source:SGD;Acc:S000001667]	pantothenate biosynthetic process, polyamine biosynthetic process, putrescine biosynthetic process	cytoplasm	carboxy-lyase activity, catalytic activity, lyase activity, ornithine decarboxylase activity		
YKL185W	ASH1	Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate [Source:SGD;Acc:S000001668]	chromatin modification, negative regulation of transcription from RNA polymerase II promoter, negative regulation of transcription, mating-type specific, pseudohyphal growth, regulation of transcription, DNA-dependent	Rpd3L complex, Rpd3L-Expanded complex, cellular bud, nucleus	DNA binding, histone deacetylase activity, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YKL186C	MTR2	mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA [Source:SGD;Acc:S000001669]	poly(A)+ mRNA export from nucleus, ribosomal large subunit export from nucleus, transport	nuclear RNA export factor complex, nuclear pore, nucleus	protein binding		
YKL187C	YKL187C	Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001670]	biological_process	mitochondrion	binding, molecular_function		
YKL188C	PXA2	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins [Source:SGD;Acc:S000001671]	fatty acid transport, transmembrane transport, transport	integral to membrane, integral to peroxisomal membrane, membrane, peroxisomal membrane, peroxisome	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YKL189W	HYM1	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response [Source:SGD;Acc:S000001672]	budding cell apical bud growth, cytokinesis, completion of separation, regulation of cell shape	cellular bud, incipient cellular bud site, intracellular, mating projection tip	binding, molecular_function		
YKL190W	CNB1	Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1 [Source:SGD;Acc:S000001673]	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, cellular ion homeostasis, fungal-type cell wall organization	calcineurin complex	calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity		
YKL191W	DPH2	Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p [Source:SGD;Acc:S000001674]	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm	molecular_function		
YKL192C	ACP1	Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p [Source:SGD;Acc:S000001675]	electron transport chain, fatty acid biosynthetic process, lipid biosynthetic process, transport	mitochondrion, respiratory chain	acyl carrier activity, cofactor binding, phosphopantetheine binding		
YKL193C	SDS22	Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis [Source:SGD;Acc:S000001676]	cell cycle, cell division, chromosome segregation, maintenance of protein location in nucleus, mitosis	cytoplasm, nucleus	enzyme regulator activity, protein binding, protein phosphatase type 1 regulator activity		
YKL194C	MST1	Mitochondrial threonyl-tRNA synthetase [Source:SGD;Acc:S000001677]	mitochondrial threonyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, threonyl-tRNA aminoacylation, translation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, threonine-tRNA ligase activity		
YKL195W	MIA40	Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins [Source:SGD;Acc:S000001678]	protein import into mitochondrial intermembrane space, protein transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial outer membrane translocase complex, mitochondrion	molecular_function		
YKL196C	YKT6	Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus [Source:SGD;Acc:S000001679]	intra-Golgi vesicle-mediated transport, transport, vesicle fusion, vesicle-mediated transport	SNARE complex, fungal-type vacuole, integral to membrane, membrane, mitochondrion, plasma membrane, soluble fraction	SNAP receptor activity, palmitoyltransferase activity, transferase activity		
YKL197C	PEX1	AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis [Source:SGD;Acc:S000001680]	peroxisome organization, protein import into peroxisome matrix, receptor recycling	cytoplasm, membrane, membrane fraction, peroxisomal membrane, peroxisome, soluble fraction	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding, protein heterodimerization activity		
YKL198C	PTK1	Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein [Source:SGD;Acc:S000001681]	polyamine transport, protein phosphorylation	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YKL201C	MNN4	Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases [Source:SGD;Acc:S000001684]	protein N-linked glycosylation, protein O-linked glycosylation, response to stress	integral to membrane, membrane	molecular_function		
YKL202W	YKL202W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001685]					
YKL203C	TOR2	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis [Source:SGD;Acc:S000001686]	G1 phase of mitotic cell cycle, Rho protein signal transduction, TOR signaling cascade, actin filament reorganization involved in cell cycle, cell cycle, cytoskeleton organization, establishment or maintenance of actin cytoskeleton polarity, negative regulation of autophagy, positive regulation of endocytosis, regulation of cell cycle, regulation of cell growth, ribosome biogenesis, signal transduction	TORC1 complex, TORC2 complex, extrinsic to internal side of plasma membrane, membrane, membrane fraction, mitochondrion, plasma membrane, vacuolar membrane, vacuole	1-phosphatidylinositol 4-kinase activity, ATP binding, binding, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein binding, protein serine/threonine kinase activity, transferase activity, transferase activity, transferring phosphorus-containing groups		
YKL204W	EAP1	eIF4E-associated protein, competes with eIF4G for binding to eIF4E; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade [Source:SGD;Acc:S000001687]	negative regulation of translation, regulation of growth, regulation of translation	cytoplasm, mRNA cap binding complex, stress granule	ATP binding, eukaryotic initiation factor 4E binding, nucleotide binding		
YKL205W	LOS1	Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm [Source:SGD;Acc:S000001688]	tRNA export from nucleus, tRNA processing, tRNA re-export from nucleus, tRNA splicing, via endonucleolytic cleavage and ligation, transport	cytoplasm, mitochondrion, nuclear matrix, nucleus	RNA binding, Ran GTPase binding, binding, tRNA binding		
YKL206C	ADD66	Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly [Source:SGD;Acc:S000001689]	ER-associated protein catabolic process, proteasome assembly	cytoplasm, cytosol	molecular_function		
YKL207W	AIM27	Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response [Source:SGD;Acc:S000001690]	protein folding in endoplasmic reticulum	ER membrane protein complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YKL208W	CBT1	Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p [Source:SGD;Acc:S000001691]	cytochrome complex assembly, mRNA processing, mRNA stabilization, rRNA processing, ribosome biogenesis	mitochondrion	molecular_function		
YKL209C	STE6	Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells [Source:SGD;Acc:S000001692]	peptide pheromone export, response to pheromone, transmembrane transport, transport	Golgi apparatus, integral to membrane, mating projection tip, membrane, plasma membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding, peptide-transporting ATPase activity		
YKL210W	UBA1	Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability [Source:SGD;Acc:S000001693]	metabolic process, protein modification process, protein ubiquitination	cytoplasm, nucleus	ATP binding, binding, catalytic activity, ligase activity, nucleotide binding, small protein activating enzyme activity, ubiquitin activating enzyme activity		
YKL211C	TRP3	Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p [Source:SGD;Acc:S000001694]	aromatic amino acid family biosynthetic process, biosynthetic process, cellular amino acid biosynthetic process, glutamine metabolic process, metabolic process, tryptophan biosynthetic process, tryptophan metabolic process	anthranilate synthase complex, cytoplasm	anthranilate synthase activity, catalytic activity, indole-3-glycerol-phosphate synthase activity, lyase activity, transferase activity		
YKL212W	SAC1	Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P; transmembrane protein localizes to ER and Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance [Source:SGD;Acc:S000001695]	phosphatidylinositol dephosphorylation	SPOTS complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to Golgi membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	hydrolase activity, phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-3-phosphatase activity, phosphatidylinositol-4-phosphate phosphatase activity, phosphoric ester hydrolase activity		
YKL213C	DOA1	WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase [Source:SGD;Acc:S000001696]	double-strand break repair via nonhomologous end joining, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus	protein binding, ubiquitin binding		
YKL214C	YRA2	Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus [Source:SGD;Acc:S000001697]	poly(A)+ mRNA export from nucleus	nucleus	RNA binding, nucleic acid binding, nucleotide binding		
YKL215C	OXP1	5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001698]	glutathione metabolic process	cytoplasm	5-oxoprolinase (ATP-hydrolyzing) activity, ATP binding, catalytic activity, hydrolase activity, nucleotide binding		
YKL216W	URA1	Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid [Source:SGD;Acc:S000001699]	'de novo' pyrimidine base biosynthetic process, UMP biosynthetic process, metabolic process, oxidation-reduction process, pyrimidine nucleotide biosynthetic process	cytoplasm, extrinsic to membrane	catalytic activity, dihydroorotate dehydrogenase activity, dihydroorotate oxidase activity, oxidoreductase activity		
YKL217W	JEN1	Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose [Source:SGD;Acc:S000001700]	lactate transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrion, plasma membrane	carbohydrate transmembrane transporter activity, lactate transmembrane transporter activity, transporter activity		
YKL218C	SRY1	3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity [Source:SGD;Acc:S000001701]	cellular amino acid metabolic process, cellular modified amino acid catabolic process, metabolic process	cellular_component	catalytic activity, lyase activity, pyridoxal phosphate binding, threo-3-hydroxyaspartate ammonia-lyase activity		
YKL219W	COS9	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000001702]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YKL220C	FRE2	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels [Source:SGD;Acc:S000001703]	copper ion import, copper ion transport, electron transport chain, ion transport, iron ion transport, oxidation-reduction process, transport	integral to membrane, membrane, plasma membrane	electron carrier activity, ferric-chelate reductase activity, flavin adenine dinucleotide binding, iron ion binding, metal ion binding, oxidoreductase activity		
YKL221W	MCH2	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport [Source:SGD;Acc:S000001704]	transmembrane transport, transport	integral to membrane, membrane	symporter activity, transporter activity		
YKL222C	YKL222C	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine [Source:SGD;Acc:S000001705]	biological_process, regulation of transcription, DNA-dependent	nucleus, ribosome	DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YKL223W	YKL223W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001706]					
YKL224C	PAU16	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000001707]	biological_process, response to stress	cellular_component	molecular_function		
YKL225W	YKL225W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001708]					
YKR001C	VPS1	Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis [Source:SGD;Acc:S000001709]	actin cytoskeleton organization, cell cycle, cell division, endocytosis, lipid tube assembly, meiosis, peroxisome fission, peroxisome organization, protein retention in Golgi apparatus, protein targeting to vacuole, vacuolar transport	cytoplasm, cytoskeleton, membrane fraction, microtubule, mitochondrial outer membrane, peroxisome	GTP binding, GTPase activity, motor activity, nucleotide binding		
YKR002W	PAP1	Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs [Source:SGD;Acc:S000001710]	RNA 3'-end processing, RNA polyadenylation, mRNA export from nucleus, mRNA polyadenylation, mRNA processing, snoRNA polyadenylation	mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus	ATP binding, RNA binding, nucleotide binding, nucleotidyltransferase activity, polynucleotide adenylyltransferase activity, transferase activity		
YKR003W	OSH6	Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000001711]	endocytosis, exocytosis, lipid transport, maintenance of cell polarity, steroid metabolic process, sterol homeostasis, sterol metabolic process, sterol transport, transport	cortical endoplasmic reticulum, cytoplasm, extrinsic to internal side of plasma membrane, peripheral to membrane of membrane fraction, soluble fraction	lipid binding, oxysterol binding, phosphatidic acid binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding		
YKR004C	ECM9	Non-essential protein of unknown function [Source:SGD;Acc:S000001712]	cellular cell wall organization, fungal-type cell wall organization	cellular_component	molecular_function		
YKR005C	YKR005C	Putative protein of unknown function [Source:SGD;Acc:S000001713]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YKR006C	MRPL13	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation [Source:SGD;Acc:S000001714]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YKR007W	MEH1	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification [Source:SGD;Acc:S000001715]	autophagy, microautophagy, protein transport, transport, vacuolar acidification	EGO complex, GSE complex, fungal-type vacuole membrane, late endosome membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YKR008W	RSC4	Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling [Source:SGD;Acc:S000001716]	ATP-dependent chromatin remodeling, G2/M transition of mitotic cell cycle, chromatin modification, nucleosome disassembly, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	DNA-dependent ATPase activity, histone acetyl-lysine binding, protein binding		
YKR009C	FOX2	Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities [Source:SGD;Acc:S000001717]	fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process, metabolic process, oxidation-reduction process	peroxisomal matrix, peroxisome	3-hydroxyacyl-CoA dehydrogenase activity, binding, catalytic activity, enoyl-CoA hydratase activity, isomerase activity, lyase activity, oxidoreductase activity		
YKR010C	TOF2	Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site [Source:SGD;Acc:S000001718]	chromatin silencing at rDNA, nucleolus organization, protein localization to nucleolar rDNA repeats, rDNA condensation	mitochondrion, nucleolus, nucleus	phosphatase activator activity		
YKR011C	YKR011C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus [Source:SGD;Acc:S000001719]	biological_process	nucleus	molecular_function		
YKR012C	YKR012C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2 [Source:SGD;Acc:S000001720]					
YKR013W	PRY2	Protein of unknown function [Source:SGD;Acc:S000001721]	biological_process	extracellular region, fungal-type vacuole	molecular_function		
YKR014C	YPT52	Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis [Source:SGD;Acc:S000001722]	endocytosis, protein targeting to vacuole, protein transport, small GTPase mediated signal transduction, transport	endoplasmic reticulum, late endosome, membrane, plasma membrane	GTP binding, GTPase activity, nucleotide binding		
YKR015C	YKR015C	Putative protein of unknown function [Source:SGD;Acc:S000001723]	biological_process	cellular_component	molecular_function		
YKR016W	FCJ1	Mitochondrial inner membrane protein involved in formation and molecular structure of crista junctions; impairs oligomerization of F1F0-ATP synthase; null shows altered mitochondrial morphology and abnormal mitochondrial genome maintenance [Source:SGD;Acc:S000001724]	cristae formation, mitochondrion degradation	integral to mitochondrial inner membrane, mitochondrial crista, mitochondrial inner membrane, mitochondrion	molecular_function		
YKR017C	YKR017C	Putative protein of unknown function; contains a RING finger motif [Source:SGD;Acc:S000001725]	biological_process	cellular_component	metal ion binding, molecular_function, nucleic acid binding, protein binding, zinc ion binding		
YKR018C	YKR018C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000001726]	biological_process	cytoplasm, integral to membrane, membrane, mitochondrial outer membrane, mitochondrion, nucleus	binding, molecular_function		
YKR019C	IRS4	EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS [Source:SGD;Acc:S000001727]	autophagy, cellular response to starvation, chromatin silencing at rDNA, fungal-type cell wall organization, inositol lipid-mediated signaling, lipid metabolic process	mitochondrion, pre-autophagosomal structure	calcium ion binding, molecular_function, protein binding		
YKR020W	VPS51	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p [Source:SGD;Acc:S000001728]	budding cell apical bud growth, protein targeting to vacuole, protein transport, regulation of cell size, retrograde transport, endosome to Golgi, transport, vesicle organization	GARP complex, Golgi apparatus, endosome, endosome membrane, membrane	protein binding		
YKR021W	ALY1	Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001729]	positive regulation of ubiquitin-dependent endocytosis, ubiquitin-dependent endocytosis	cytoplasm	ubiquitin protein ligase binding		
YKR022C	NTR2	Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly [Source:SGD;Acc:S000001730]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome, spliceosome disassembly	U2-type post-mRNA release spliceosomal complex, cytoplasm, endoplasmic reticulum, nucleus, spliceosomal complex	molecular_function		
YKR023W	YKR023W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001731]	biological_process	cytoplasm, mitochondrion, nucleus	molecular_function, zinc ion binding		
YKR024C	DBP7	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions [Source:SGD;Acc:S000001732]	rRNA processing, ribosomal large subunit assembly, ribosome biogenesis	nucleolus, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YKR025W	RPC37	RNA polymerase III subunit C37 [Source:SGD;Acc:S000001733]	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase III complex, nucleus	DNA-directed RNA polymerase activity		
YKR026C	GCN3	Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression [Source:SGD;Acc:S000001734]	cellular metabolic process, regulation of translation, regulation of translational initiation, translation	eukaryotic translation initiation factor 2B complex, guanyl-nucleotide exchange factor complex	enzyme regulator activity, guanyl-nucleotide exchange factor activity, translation initiation factor activity		
YKR027W	BCH2	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane [Source:SGD;Acc:S000001735]	Golgi to plasma membrane transport, fungal-type cell wall chitin biosynthetic process, protein transport, transport	Golgi apparatus, clathrin-coated vesicle, exomer complex, membrane, mitochondrion, trans-Golgi network transport vesicle	binding, molecular_function		
YKR028W	SAP190	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p [Source:SGD;Acc:S000001736]	G1/S transition of mitotic cell cycle, TOR signaling cascade, cell cycle, dephosphorylation, tRNA wobble uridine modification	cytoplasm	molecular_function		
YKR029C	SET3	Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains [Source:SGD;Acc:S000001737]	chromatin modification, histone deacetylation, meiosis, negative regulation of meiosis	Rpd3L-Expanded complex, Set3 complex	metal ion binding, methylated histone residue binding, protein binding, zinc ion binding		
YKR030W	GMH1	Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting [Source:SGD;Acc:S000001738]	transport	Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to Golgi membrane, integral to membrane, membrane	molecular_function		
YKR031C	SPO14	Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis [Source:SGD;Acc:S000001739]	ascospore-type prospore formation, cell communication, cell morphogenesis involved in conjugation with cellular fusion, exocytosis, lipid catabolic process, meiosis, metabolic process, phospholipid metabolic process, sporulation resulting in formation of a cellular spore	endosome, prospore membrane	NAPE-specific phospholipase D activity, catalytic activity, hydrolase activity, phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, phospholipase D activity, protein binding		
YKR032W	YKR032W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001740]					
YKR033C	YKR033C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 [Source:SGD;Acc:S000001741]					
YKR034W	DAL80	Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p [Source:SGD;Acc:S000001742]	nitrate assimilation, nitrogen catabolite repression of transcription, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YKR035C	OPI8	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A [Source:SGD;Acc:S000001743]					
YKR035W-A	DID2	Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors [Source:SGD;Acc:S000006435]	late endosome to vacuole transport, late endosome to vacuole transport via multivesicular body sorting pathway, protein targeting to vacuole, protein transport, transport	cytoplasm, endomembrane system, endosome, endosome membrane, late endosome, membrane	molecular_function		
YKR036C	CAF4	WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission [Source:SGD;Acc:S000001744]	mitochondrial fission, peroxisome fission, regulation of transcription from RNA polymerase II promoter	CCR4-NOT complex, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YKR037C	SPC34	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body [Source:SGD;Acc:S000001745]	cell cycle, cell division, chromosome segregation, microtubule nucleation, mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization	DASH complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle, spindle microtubule, spindle pole body	microtubule binding, structural constituent of cytoskeleton		
YKR038C	KAE1	Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription [Source:SGD;Acc:S000001746]	chromosome organization, positive regulation of transcription from RNA polymerase II promoter, proteolysis, telomere maintenance, threonylcarbamoyladenosine metabolic process	EKC/KEOPS complex, chromosome, telomeric region, cytoplasm, nuclear chromatin, nucleus	chromatin DNA binding, endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding		
YKR039W	GAP1	General amino acid permease; localization to the plasma membrane is regulated by nitrogen source [Source:SGD;Acc:S000001747]	amino acid transport, ammonia assimilation cycle, gamma-aminobutyric acid transport, polyamine transport, transmembrane transport, transport	ER to Golgi transport vesicle, endosome, fungal-type vacuole lumen, integral to membrane, integral to plasma membrane, membrane, multivesicular body, plasma membrane	L-proline transmembrane transporter activity, amino acid transmembrane transporter activity, polyamine transmembrane transporter activity		
YKR040C	YKR040C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W [Source:SGD;Acc:S000001748]					
YKR041W	YKR041W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000001749]	biological_process	cytoplasm, nucleus	molecular_function		
YKR042W	UTH1	Mitochondrial outer membrane and cell wall localized SUN family member involved in cell wall biogenesis and required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, and cell death [Source:SGD;Acc:S000001750]	autophagy, barrier septum formation, cell cycle, cell division, cellular cell wall organization, fungal-type cell wall biogenesis, loss of chromatin silencing involved in replicative cell aging, mitochondrion degradation, response to stress	cell wall, extracellular region, fungal-type cell wall, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YKR043C	YKR043C	Metal-independent fructose 1,6-bisphosphatase, may play a role in gluconeogenesis under metal-limiting conditions; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000001751]	biological_process	cytoplasm, nucleus	fructose 1,6-bisphosphate 1-phosphatase activity		
YKR044W	UIP5	Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates [Source:SGD;Acc:S000001752]	biological_process	integral to membrane, membrane, nuclear envelope, nuclear membrane, nucleus	molecular_function		
YKR045C	YKR045C	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm [Source:SGD;Acc:S000001753]	biological_process	cytoplasm	molecular_function		
YKR046C	PET10	Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange [Source:SGD;Acc:S000001754]	aerobic respiration	lipid particle, membrane	molecular_function		
YKR047W	YKR047W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 [Source:SGD;Acc:S000001755]					
YKR048C	NAP1	Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2 [Source:SGD;Acc:S000001756]	M phase of mitotic cell cycle, budding cell bud growth, nucleosome assembly, nucleosome disassembly, protein import into nucleus	cellular bud neck, cytoplasm, nuclear nucleosome, nucleus	DNA binding, cyclin binding, histone binding		
YKR049C	FMP46	Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001757]	biological_process, oxidation-reduction process	mitochondrion	oxidoreductase activity		
YKR050W	TRK2	Component of the Trk1p-Trk2p potassium transport system [Source:SGD;Acc:S000001758]	cation transport, cellular potassium ion homeostasis, ion transport, potassium ion transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	cation transmembrane transporter activity, potassium ion transmembrane transporter activity		
YKR051W	YKR051W	Putative protein of unknown function [Source:SGD;Acc:S000001759]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YKR052C	MRS4	Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs3p; active under low-iron conditions; may transport other cations [Source:SGD;Acc:S000001760]	RNA splicing, mRNA processing, mitochondrial iron ion transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, iron ion transmembrane transporter activity		
YKR053C	YSR3	Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism; has similarity to Lcb3p [Source:SGD;Acc:S000001761]	lipid metabolic process, sphingolipid biosynthetic process, sphingolipid metabolic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	catalytic activity, hydrolase activity, sphingosine-1-phosphate phosphatase activity		
YKR054C	DYN1	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p [Source:SGD;Acc:S000001762]	establishment of mitotic spindle orientation, karyogamy, microtubule-based movement, mitotic sister chromatid segregation, mitotic spindle elongation, nuclear migration along microtubule	astral microtubule, cell cortex, cytoplasm, cytoplasmic dynein complex, cytoplasmic microtubule, cytoskeleton, dynein complex, microtubule, spindle pole body	ATP binding, ATPase activity, microtubule motor activity, motor activity, nucleoside-triphosphatase activity, nucleotide binding		
YKR055W	RHO4	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity [Source:SGD;Acc:S000001763]	maintenance of cell polarity, positive regulation of formin-nucleated actin cable assembly, regulation of formin-nucleated actin cable assembly, small GTPase mediated signal transduction	cellular bud neck, intracellular, membrane, membrane fraction, plasma membrane	GTP binding, GTPase activity, nucleotide binding		
YKR056W	TRM2	tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair [Source:SGD;Acc:S000001764]	DNA repair, RNA processing, double-strand break repair, tRNA modification, tRNA processing	cellular_component	RNA methyltransferase activity, double-stranded DNA specific 5'-3' exodeoxyribonuclease activity, methyltransferase activity, single-stranded DNA specific endodeoxyribonuclease activity, tRNA (m5U54) methyltransferase activity, tRNA (uracil-5-)-methyltransferase activity, transferase activity		
YKR057W	RPS21A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein [Source:SGD;Acc:S000001765]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YKR058W	GLG1	Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin [Source:SGD;Acc:S000001766]	glycogen biosynthetic process	cellular_component	glycogenin glucosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YKR059W	TIF1	Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G [Source:SGD;Acc:S000001767]	translation, translational initiation	cytoplasm, eukaryotic translation initiation factor 4F complex, ribosome	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, translation initiation factor activity		
YKR060W	UTP30	Subunit of U3-containing 90S preribosome complex involved in production of 18S rRNA and assembly of small ribosomal subunit [Source:SGD;Acc:S000001768]	RNA processing, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis	90S preribosome, nucleolus, nucleus	RNA binding, molecular_function		
YKR061W	KTR2	Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000001769]	cell wall mannoprotein biosynthetic process, protein N-linked glycosylation, protein glycosylation	Golgi apparatus, Golgi membrane, integral to membrane, membrane	glycolipid 2-alpha-mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YKR062W	TFA2	TFIIE small subunit, involved in RNA polymerase II transcription initiation [Source:SGD;Acc:S000001770]	transcription initiation from RNA polymerase II promoter	nucleus, transcription factor TFIIE complex	DNA binding		
YKR063C	LAS1	Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability [Source:SGD;Acc:S000001771]	budding cell bud growth, establishment of cell polarity	mitochondrion, nucleus	molecular_function		
YKR064W	OAF3	Zinc cluster protein; regulates transcription in response to oleate levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001772]	fatty acid metabolic process, regulation of transcription, DNA-dependent	cytoplasm, mitochondrion, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YKR065C	PAM17	Constituent of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 complex [Source:SGD;Acc:S000001773]	protein import into mitochondrial matrix, protein transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion, presequence translocase-associated import motor	molecular_function		
YKR066C	CCP1	Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress [Source:SGD;Acc:S000001774]	cellular response to oxidative stress, hydrogen peroxide catabolic process, oxidation-reduction process, response to oxidative stress	mitochondrial intermembrane space, mitochondrial matrix, mitochondrion	cytochrome-c peroxidase activity, heme binding, metal ion binding, oxidoreductase activity, peroxidase activity		
YKR067W	GPT2	Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis [Source:SGD;Acc:S000001775]	metabolic process, phospholipid biosynthetic process	cytoplasm, endoplasmic reticulum, integral to membrane, membrane, microsome	acyltransferase activity, glycerol-3-phosphate O-acyltransferase activity, glycerone-phosphate O-acyltransferase activity, transferase activity		
YKR068C	BET3	Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex [Source:SGD;Acc:S000001776]	ER to Golgi vesicle-mediated transport, cGMP biosynthetic process, intra-Golgi vesicle-mediated transport, transport, vesicle-mediated transport	Golgi apparatus, TRAPP complex, cis-Golgi network membrane, endoplasmic reticulum	Rab guanyl-nucleotide exchange factor activity, guanylate cyclase activity, heme binding		
YKR069W	MET1	S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis [Source:SGD;Acc:S000001777]	cellular amino acid biosynthetic process, metabolic process, methionine biosynthetic process, oxidation-reduction process, porphyrin biosynthetic process, siroheme biosynthetic process, sulfate assimilation	intracellular	binding, catalytic activity, methyltransferase activity, transferase activity, uroporphyrin-III C-methyltransferase activity		
YKR070W	YKR070W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001778]	biological_process, metabolic process	mitochondrion	catalytic activity, hydrolase activity, molecular_function		
YKR071C	DRE2	Conserved component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p; ortholog of human Ciapin1 [Source:SGD;Acc:S000001779]	apoptosis, iron-sulfur cluster assembly	cytoplasm, cytosol, mitochondrial intermembrane space, mitochondrion	2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, electron carrier activity, iron-sulfur cluster binding, metal ion binding		
YKR072C	SIS2	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis [Source:SGD;Acc:S000001780]	coenzyme A biosynthetic process, regulation of mitotic cell cycle, response to salt stress	cytoplasm, nucleus, phosphopantothenoylcysteine decarboxylase complex	catalytic activity, phosphopantothenoylcysteine decarboxylase activity, protein phosphatase inhibitor activity		
YKR073C	YKR073C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001781]					
YKR074W	AIM29	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000001782]	biological_process	cytoplasm	molecular_function		
YKR075C	YKR075C	Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000001783]	biological_process	cytoplasm, nucleus	molecular_function		
YKR075W-A	YKR075W-A	Dubious open reading frame unlikely to encode a protein; completely overlaps the uncharacterized gene YKR075W; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028669]					
YKR076W	ECM4	Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001784]	cellular cell wall organization, fungal-type cell wall organization, glutathione metabolic process	cytoplasm	glutathione transferase activity, transferase activity		
YKR077W	MSA2	Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation [Source:SGD;Acc:S000001785]	regulation of transcription involved in G1 phase of mitotic cell cycle	cytoplasm, nucleus	molecular_function		
YKR078W	YKR078W	Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) [Source:SGD;Acc:S000001786]	biological_process, cell communication	cytoplasm	phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding		
YKR079C	TRZ1	tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2 [Source:SGD;Acc:S000001787]	tRNA 3'-trailer cleavage, endonucleolytic, tRNA processing	cytoplasm, mitochondrion, nucleus	3'-tRNA processing endoribonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity		
YKR080W	MTD1	NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline [Source:SGD;Acc:S000001788]	folic acid-containing compound biosynthetic process, metabolic process, one-carbon metabolic process, oxidation-reduction process, purine base biosynthetic process, purine nucleotide biosynthetic process	cytoplasm, cytosol, nucleus	binding, catalytic activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity, oxidoreductase activity		
YKR081C	RPF2	Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles [Source:SGD;Acc:S000001789]	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal large subunit assembly	nucleolus, nucleus, preribosome, large subunit precursor	5S rRNA binding, 7S RNA binding, rRNA binding		
YKR082W	NUP133	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p [Source:SGD;Acc:S000001790]	NLS-bearing substrate import into nucleus, chromosome localization, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	Nup107-160 complex, membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YKR083C	DAD2	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000001791]	cell cycle, cell division, chromosome segregation, mitosis, mitotic spindle organization in nucleus, regulation of microtubule polymerization or depolymerization	DASH complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle	microtubule binding, structural constituent of cytoskeleton		
YKR084C	HBS1	GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay [Source:SGD;Acc:S000001792]	nonfunctional rRNA decay, nuclear-transcribed mRNA catabolic process, no-go decay, regulation of translation, ribosome disassembly, translation	cytoplasm	GTP binding, GTPase activity, nucleotide binding, translation elongation factor activity, translation release factor activity, codon nonspecific		
YKR085C	MRPL20	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000001793]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YKR086W	PRP16	RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity [Source:SGD;Acc:S000001794]	RNA splicing, generation of catalytic spliceosome for second transesterification step, mRNA processing	U2-type catalytic step 2 spliceosome, nucleus	ATP binding, ATP-dependent helicase activity, RNA-dependent ATPase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, second spliceosomal transesterification activity		
YKR087C	OMA1	Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes [Source:SGD;Acc:S000001795]	misfolded or incompletely synthesized protein catabolic process, proteolysis	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity		
YKR088C	TVP38	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000001796]	mitotic spindle elongation, vesicle-mediated transport	Golgi apparatus, Golgi membrane, cytoplasm, integral to Golgi membrane, integral to membrane, membrane	molecular_function		
YKR089C	TGL4	Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p [Source:SGD;Acc:S000001797]	cell budding, lipid catabolic process, lipid metabolic process, metabolic process, phospholipid metabolic process, sporulation resulting in formation of a cellular spore, triglyceride catabolic process, triglyceride mobilization	integral to membrane, lipid particle, membrane	GTP binding, calcium-independent phospholipase A2 activity, hydrolase activity, lysophosphatidic acid acyltransferase activity, sterol esterase activity, triglyceride lipase activity		
YKR090W	PXL1	LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin [Source:SGD;Acc:S000001798]	maintenance of cell polarity	cellular bud, cellular bud neck, cellular bud tip, cytoplasm, incipient cellular bud site, mating projection tip	metal ion binding, zinc ion binding		
YKR091W	SRL3	Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate [Source:SGD;Acc:S000001799]	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	cytoplasm	molecular_function		
YKR092C	SRP40	Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 [Source:SGD;Acc:S000001800]	nucleocytoplasmic transport	nucleolus	molecular_function		
YKR093W	PTR2	Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p [Source:SGD;Acc:S000001801]	dipeptide transport, oligopeptide transport, peptide transport, protein transport, transport, tripeptide transport	integral to membrane, integral to plasma membrane, membrane, membrane fraction, plasma membrane	dipeptide transporter activity, peptide transporter activity, transporter activity, tripeptide transporter activity		
YKR094C	RPL40B	Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes [Source:SGD;Acc:S000001802]	DNA repair, protein ubiquitination, response to DNA damage stimulus, ribosome biogenesis, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, mitochondrion, nucleus, ribonucleoprotein complex, ribosome	protein binding, protein tag, structural constituent of ribosome		
YKR095W	MLP1	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs [Source:SGD;Acc:S000001803]	DNA repair, mRNA export from nucleus, mRNA transport, maintenance of RNA location, nuclear retention of unspliced pre-mRNA at the site of transcription, protein import into nucleus, protein localization to nuclear pore, response to DNA damage stimulus, transcriptional activation by promoter-terminator looping, transport	nuclear envelope, nuclear pore, nucleoplasm, nucleus, ribonucleoprotein complex, spindle pole body	protein binding, ribonucleoprotein binding		
YKR095W-A	PCC1	Component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription [Source:SGD;Acc:S000028512]	positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter by pheromones, threonylcarbamoyladenosine metabolic process	EKC/KEOPS complex, chromosome, telomeric region, nuclear chromatin, nucleus	chromatin DNA binding		
YKR096W	YKR096W	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain [Source:SGD;Acc:S000001804]	biological_process	cytoplasm, nucleus, ribosome	ATP binding, molecular_function, nucleotide binding		
YKR097W	PCK1	Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol [Source:SGD;Acc:S000001805]	gluconeogenesis, metabolic process, oxidation-reduction process	cytosol	ATP binding, carboxy-lyase activity, lyase activity, nucleotide binding, oxidoreductase activity, phosphoenolpyruvate carboxykinase (ATP) activity, phosphoenolpyruvate carboxykinase activity, purine nucleotide binding		
YKR098C	UBP11	Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins [Source:SGD;Acc:S000001806]	biological_process, ubiquitin-dependent protein catabolic process	cellular_component	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YKR099W	BAS1	Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes [Source:SGD;Acc:S000001807]	histidine biosynthetic process, purine base biosynthetic process, reciprocal meiotic recombination, transcription from RNA polymerase II promoter	nucleus	DNA binding, protein binding, sequence-specific DNA binding		
YKR100C	SKG1	Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell [Source:SGD;Acc:S000001808]	cellular cell wall organization, fungal-type cell wall organization	cellular bud, cellular bud membrane, cellular bud tip, incipient cellular bud site, integral to membrane, membrane, plasma membrane	molecular_function		
YKR101W	SIR1	Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin [Source:SGD;Acc:S000001809]	chromatin silencing at silent mating-type cassette, establishment of chromatin silencing	chromatin silencing complex, chromosome, centromeric region, nucleus	chromatin binding, sequence-specific DNA binding		
YKR102W	FLO10	Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation [Source:SGD;Acc:S000001810]	flocculation, flocculation via cell wall protein-carbohydrate interaction	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	mannose binding		
YKR103W	NFT1	Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. [Source:SGD;Acc:S000001811]	transmembrane transport, transport	integral to membrane, membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YKR104W	YKR104W	Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds [Source:SGD;Acc:S000001812]	transport	membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YKR105C	VBA5	Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny [Source:SGD;Acc:S000001813]	amino acid transport, biological_process, transmembrane transport, transport	cellular_component, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function, transporter activity		
YKR106W	YKR106W	Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YCL073C [Source:SGD;Acc:S000001814]	transmembrane transport, transport	integral to membrane, membrane	transporter activity		
YLL001W	DNM1	Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance [Source:SGD;Acc:S000003924]	chronological cell aging, mitochondrial fission, mitochondrion inheritance, mitochondrion organization, peroxisome fission, peroxisome organization, protein homooligomerization	membrane, mitochondrial outer membrane, mitochondrion, peroxisome	GTP binding, GTPase activity, hydrolase activity, identical protein binding, motor activity, nucleotide binding, protein homodimerization activity		
YLL002W	RTT109	Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p [Source:SGD;Acc:S000003925]	DNA repair, double-strand break repair via nonhomologous end joining, histone acetylation, negative regulation of transposition, RNA-mediated, regulation of transcription from RNA polymerase II promoter in response to stress, response to DNA damage stimulus	nucleus	H3 histone acetyltransferase activity, histone acetyltransferase activity, transferase activity		
YLL003W	SFI1	Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C [Source:SGD;Acc:S000003926]	G2/M transition of mitotic cell cycle, cell cycle, cell division, mitosis, spindle assembly, spindle pole body duplication in nuclear envelope	cytoplasm, cytoskeleton, half bridge of spindle pole body, spindle pole	molecular_function		
YLL004W	ORC3	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing [Source:SGD;Acc:S000003927]	DNA replication, DNA-dependent DNA replication initiation, chromatin silencing at silent mating-type cassette, pre-replicative complex assembly	DNA replication preinitiation complex, nuclear origin of replication recognition complex, nucleus, pre-replicative complex	DNA binding, DNA replication origin binding, chromatin binding		
YLL005C	SPO75	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis [Source:SGD;Acc:S000003928]	ascospore formation, ascospore wall assembly, sporulation resulting in formation of a cellular spore	cellular_component, integral to membrane, membrane	molecular_function		
YLL006W	MMM1	ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth [Source:SGD;Acc:S000003929]	mitochondrial genome maintenance, mitochondrion organization, phospholipid transport, protein import into mitochondrial outer membrane	ERMES complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YLL006W-A	YLL006W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028560]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YLL007C	YLL007C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene [Source:SGD;Acc:S000003930]	biological_process	cytoplasm	molecular_function		
YLL008W	DRS1	Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles [Source:SGD;Acc:S000003931]	rRNA processing, ribosomal large subunit assembly, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YLL009C	COX17	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000003932]	copper ion transport, intracellular copper ion transport, mitochondrial respiratory chain complex IV assembly	cytosol, mitochondrial intermembrane space, mitochondrion	copper chaperone activity, copper ion binding, metal ion binding		
YLL010C	PSR1	Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p [Source:SGD;Acc:S000003933]	response to stress	membrane, plasma membrane	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding		
YLL011W	SOF1	Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p [Source:SGD;Acc:S000003934]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, nucleolus, nucleus, ribonucleoprotein complex, small nucleolar ribonucleoprotein complex, small-subunit processome	molecular_function, protein binding		
YLL012W	YEH1	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes [Source:SGD;Acc:S000003935]	lipid catabolic process, lipid metabolic process, sterol metabolic process	integral to membrane, lipid particle, membrane	hydrolase activity, sterol esterase activity		
YLL013C	PUF3	Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins [Source:SGD;Acc:S000003936]	aerobic respiration, intracellular mRNA localization, mitochondrion localization, mitochondrion organization, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	cytoplasm, external side of mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion	RNA binding, binding, mRNA binding		
YLL014W	EMC6	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response [Source:SGD;Acc:S000003937]	protein folding in endoplasmic reticulum	ER membrane protein complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YLL015W	BPT1	ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p [Source:SGD;Acc:S000003938]	bilirubin transport, cadmium ion transport, transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, bilirubin transmembrane transporter activity, cadmium ion transmembrane transporter activity, nucleoside-triphosphatase activity, nucleotide binding		
YLL018C	DPS1	Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation [Source:SGD;Acc:S000003941]	aspartyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, nucleus	ATP binding, RNA binding, aminoacyl-tRNA ligase activity, aspartate-tRNA ligase activity, ligase activity, nucleic acid binding, nucleotide binding		
YLL018C-A	COX19	Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000007245]	metal ion transport, mitochondrial respiratory chain complex IV assembly	cytoplasm, cytosol, mitochondrial intermembrane space, mitochondrion	copper chaperone activity, copper ion binding		
YLL019C	KNS1	Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues [Source:SGD;Acc:S000003942]	protein autophosphorylation, protein phosphorylation	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity		
YLL019W-A	YLL019W-A	Dubious open reading frame unlikely to encode a protein; completely overlaps the verified gene KNS1 [Source:SGD;Acc:S000028670]					
YLL020C	YLL020C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1 [Source:SGD;Acc:S000003943]					
YLL021W	SPA2	Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate [Source:SGD;Acc:S000003944]	Rho protein signal transduction, actin filament organization, bipolar cellular bud site selection, establishment of cell polarity, pseudohyphal growth, regulation of cell shape, regulation of initiation of mating projection growth, regulation of termination of mating projection growth	cell tip, cellular bud neck, cellular bud tip, incipient cellular bud site, mating projection tip, polarisome	cytoskeletal regulatory protein binding		
YLL022C	HIF1	Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing [Source:SGD;Acc:S000003945]	chromatin modification, chromatin silencing at telomere, histone acetylation, nucleosome assembly	histone acetyltransferase complex, nucleus	binding, histone binding		
YLL023C	POM33	Transmembrane nucleoporin involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p [Source:SGD;Acc:S000003946]	nuclear pore organization	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear pore, ribosome	molecular_function		
YLL024C	SSA2	ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall [Source:SGD;Acc:S000003947]	SRP-dependent cotranslational protein targeting to membrane, translocation, protein folding, response to stress	cell wall, chaperonin-containing T-complex, cytoplasm, cytosol, extracellular region, fungal-type cell wall, fungal-type vacuole membrane, mitochondrion, plasma membrane enriched fraction	ATP binding, ATPase activity, nucleotide binding, unfolded protein binding		
YLL025W	PAU17	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene [Source:SGD;Acc:S000003948]	biological_process, response to stress	cellular_component	molecular_function		
YLL026W	HSP104	Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation [Source:SGD;Acc:S000003949]	cellular heat acclimation, chaperone cofactor-dependent protein refolding, inheritance of oxidatively modified proteins involved in replicative cell aging, protein folding in endoplasmic reticulum, protein metabolic process, protein unfolding, response to stress, trehalose metabolism in response to heat stress	TRC complex, cytoplasm, nucleus	ADP binding, ATP binding, ATPase activity, coupled, chaperone binding, nucleoside-triphosphatase activity, nucleotide binding, unfolded protein binding		
YLL027W	ISA1	Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources [Source:SGD;Acc:S000003950]	biotin biosynthetic process, iron-sulfur cluster assembly	mitochondrial matrix, mitochondrion	iron-sulfur cluster binding, molecular_function, structural molecule activity		
YLL028W	TPO1	Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane [Source:SGD;Acc:S000003951]	drug transport, putrescine transport, spermidine transport, spermine transport, transmembrane transport, transport	cellular bud membrane, integral to membrane, membrane, plasma membrane, vacuolar membrane	antiporter activity, drug transmembrane transporter activity, spermidine transmembrane transporter activity, spermine transmembrane transporter activity		
YLL029W	FRA1	Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation [Source:SGD;Acc:S000003952]	cellular process, negative regulation of transcription from RNA polymerase II promoter in response to iron, proteolysis	cytoplasm, cytosol	aminopeptidase activity, hydrolase activity, metal ion binding, metalloexopeptidase activity, metallopeptidase activity, molecular_function, peptidase activity		
YLL030C	RRT7	Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003953]					
YLL031C	GPI13	ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein [Source:SGD;Acc:S000003954]	GPI anchor biosynthetic process, cellular cell wall organization, metabolic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	catalytic activity, mannose-ethanolamine phosphotransferase activity, transferase activity, transferase activity, transferring phosphorus-containing groups		
YLL032C	YLL032C	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene [Source:SGD;Acc:S000003955]	biological_process	cytoplasm, ribosome	RNA binding, molecular_function		
YLL033W	IRC19	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000003956]	ascospore formation, mitotic recombination, sporulation resulting in formation of a cellular spore	cellular_component	molecular_function		
YLL034C	RIX7	Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions [Source:SGD;Acc:S000003957]	ribosomal large subunit biogenesis, ribosomal large subunit export from nucleus, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding		
YLL035W	GRC3	Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated [Source:SGD;Acc:S000003958]	rRNA processing, termination of RNA polymerase I transcription	nucleolar chromatin, nucleolus, nucleus	ATP binding, kinase activity, nucleotide binding, polynucleotide 5'-hydroxyl-kinase activity, transferase activity		
YLL036C	PRP19	Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases [Source:SGD;Acc:S000003959]	DNA repair, RNA splicing, generation of catalytic spliceosome for first transesterification step, mRNA processing, protein ubiquitination, response to DNA damage stimulus	Prp19 complex, U2-type catalytic step 1 spliceosome, cytoplasm, mitochondrion, nucleus, spliceosomal complex, ubiquitin ligase complex	first spliceosomal transesterification activity, protein binding, ubiquitin-protein ligase activity		
YLL037W	YLL037W	Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor [Source:SGD;Acc:S000003960]					
YLL038C	ENT4	Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome [Source:SGD;Acc:S000003961]	actin cortical patch assembly, actin filament organization, endocytosis, establishment of protein localization in plasma membrane	actin cortical patch	clathrin binding		
YLL039C	UBI4	Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats [Source:SGD;Acc:S000003962]	DNA repair, ascospore formation, protein deubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, response to DNA damage stimulus, response to stress	cytoplasm, nucleus	ATP-dependent protein binding, protein binding, protein tag		
YLL040C	VPS13	Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention [Source:SGD;Acc:S000003963]	ascospore formation, late endosome to vacuole transport, protein localization, protein retention in Golgi apparatus, protein transport, transport, vacuolar protein catabolic process	Golgi apparatus, endosome, extrinsic to membrane, mitochondrion	molecular_function		
YLL041C	SDH2	Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain [Source:SGD;Acc:S000003964]	cellular respiration, electron transport chain, mitochondrial electron transport, succinate to ubiquinone, oxidation-reduction process, transport, tricarboxylic acid cycle	membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrial respiratory chain complex II, mitochondrion	2 iron, 2 sulfur cluster binding, 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, electron carrier activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, succinate dehydrogenase (ubiquinone) activity		
YLL042C	ATG10	Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy [Source:SGD;Acc:S000003965]	CVT pathway, autophagy, macroautophagy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein modification process, protein transport, transport	cellular_component, cytoplasm	Atg12 ligase activity, ligase activity		
YLL043W	FPS1	Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress [Source:SGD;Acc:S000003966]	acetate transport, arsenite transport, conjugation with cellular fusion, glycerol metabolic process, glycerol transport, response to arsenic-containing substance, transmembrane transport, transport	cytoplasm, fungal-type vacuole, integral to membrane, membrane, plasma membrane	glycerol transmembrane transporter activity, transporter activity		
YLL044W	YLL044W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant [Source:SGD;Acc:S000003967]					
YLL045C	RPL8B	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits [Source:SGD;Acc:S000003968]	ribosome biogenesis, translation	cytoplasm, cytosolic large ribosomal subunit, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YLL046C	RNP1	Ribonucleoprotein that contains two RNA recognition motifs (RRM) [Source:SGD;Acc:S000003969]	ribosome biogenesis	cytoplasm	RNA binding, nucleic acid binding, nucleotide binding		
YLL047W	YLL047W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 [Source:SGD;Acc:S000003970]					
YLL048C	YBT1	Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters [Source:SGD;Acc:S000003971]	bile acid and bile salt transport, transmembrane transport, transport	fungal-type vacuole, integral to membrane, membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, bile acid transmembrane transporter activity, nucleoside-triphosphatase activity, nucleotide binding		
YLL049W	LDB18	Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 [Source:SGD;Acc:S000003972]	establishment of mitotic spindle orientation	astral microtubule, cell cortex, dynactin complex, spindle pole body	molecular_function		
YLL050C	COF1	Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes [Source:SGD;Acc:S000003973]	actin filament depolymerization, actin filament severing	actin cortical patch, cytoplasm, cytoskeleton, intracellular, nuclear matrix, nucleus, plasma membrane enriched fraction	actin binding, actin filament binding		
YLL051C	FRE6	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels [Source:SGD;Acc:S000003974]	copper ion import, electron transport chain, intracellular sequestering of iron ion, ion transport, iron ion transport, oxidation-reduction process, transport	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	electron carrier activity, ferric-chelate reductase activity, flavin adenine dinucleotide binding, iron ion binding, metal ion binding, oxidoreductase activity		
YLL052C	AQY2	Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains [Source:SGD;Acc:S000003975]	transport, water transport	endoplasmic reticulum membrane, membrane, plasma membrane	transporter activity, water channel activity		
YLL053C	YLL053C	Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin [Source:SGD;Acc:S000003976]	biological_process, transport	cellular_component, integral to membrane, membrane	molecular_function, transporter activity		
YLL054C	YLL054C	Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene [Source:SGD;Acc:S000003977]	biological_process, regulation of transcription, DNA-dependent	nucleus, plasma membrane	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YLL055W	YCT1	High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene [Source:SGD;Acc:S000003978]	cysteine transport, transmembrane transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	cysteine transmembrane transporter activity, ion transmembrane transporter activity		
YLL056C	YLL056C	Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000003979]	biological_process, cellular metabolic process, metabolic process	cellular_component	binding, catalytic activity, coenzyme binding, molecular_function		
YLL057C	JLP1	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation [Source:SGD;Acc:S000003980]	oxidation-reduction process, sulfur compound catabolic process	cellular_component	metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, sulfonate dioxygenase activity		
YLL058W	YLL058W	Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene [Source:SGD;Acc:S000003981]	cellular amino acid biosynthetic process, cellular amino acid metabolic process, methionine biosynthetic process, sulfur compound metabolic process	cellular_component	catalytic activity, cystathionine gamma-synthase activity, pyridoxal phosphate binding, transferase activity		
YLL059C	YLL059C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003982]					
YLL060C	GTT2	Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p [Source:SGD;Acc:S000003983]	glutathione metabolic process	mitochondrion	glutathione transferase activity, protein binding, transferase activity		
YLL061W	MMP1	High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p [Source:SGD;Acc:S000003984]	S-methylmethionine transport, amino acid transport, transmembrane transport, transport	endoplasmic reticulum, integral to membrane, membrane, plasma membrane	S-methylmethionine transmembrane transporter activity, amino acid transmembrane transporter activity		
YLL062C	MHT1	S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio [Source:SGD;Acc:S000003985]	cellular amino acid biosynthetic process, methionine biosynthetic process, sulfur amino acid metabolic process	cytoplasm	homocysteine S-methyltransferase activity, metal ion binding, methyltransferase activity, transferase activity		
YLL063C	AYT1	Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis [Source:SGD;Acc:S000003986]	secondary metabolic process	cellular_component	acyltransferase activity, transferase activity, transferase activity, transferring acyl groups other than amino-acyl groups, trichothecene 3-O-acetyltransferase activity		
YLL064C	PAU18	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p [Source:SGD;Acc:S000003987]	biological_process, response to stress	cellular_component	molecular_function		
YLL065W	YLL065W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps chromosome XII telomeric element core sequences [Source:SGD;Acc:S000003988]					
YLL066C	YLL066C	Putative protein of unknown function with similarity to helicases; YLL066C is not an essential gene [Source:SGD;Acc:S000003989]	biological_process	cellular_component	ATP binding, ATP-dependent helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YLL066W-A	YLL066W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YLL066C [Source:SGD;Acc:S000028671]					
YLL066W-B	YLL066W-B	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest [Source:SGD;Acc:S000028672]	biological_process	cellular_component	molecular_function		
YLL067C	YLL067C	Putative protein of unknown function with similarity to helicases [Source:SGD;Acc:S000003990]	biological_process	cellular_component	ATP binding, ATP-dependent helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YLL067W-A	YLL067W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps YLL067C [Source:SGD;Acc:S000028673]					
YLR001C	YLR001C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated [Source:SGD;Acc:S000003991]	biological_process	fungal-type vacuole membrane, integral to membrane, membrane, mitochondrion, vacuolar membrane, vacuole	molecular_function		
YLR002C	NOC3	Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation [Source:SGD;Acc:S000003992]	DNA replication, DNA-dependent DNA replication initiation, cell cycle, cell division, rRNA processing, ribosome biogenesis	Noc2p-Noc3p complex, nucleolus, nucleus	chromatin binding		
YLR003C	CMS1	Subunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; overexpression rescues supressor mutant of mcm10; null mutant is viable [Source:SGD;Acc:S000003993]	ribosomal small subunit biogenesis	90S preribosome, nucleus	molecular_function		
YLR004C	THI73	Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs [Source:SGD;Acc:S000003994]	transmembrane transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, plasma membrane	transporter activity		
YLR005W	SSL1	Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p [Source:SGD;Acc:S000003995]	DNA repair, nucleotide-excision repair, phosphorylation of RNA polymerase II C-terminal domain, response to DNA damage stimulus	core TFIIH complex, holo TFIIH complex, intracellular, nucleotide-excision repair factor 3 complex, nucleus	metal ion binding, protein binding, zinc ion binding		
YLR006C	SSK1	Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate [Source:SGD;Acc:S000003996]	activation of MAPKKK activity involved in osmosensory signaling pathway, osmosensory signaling pathway via two-component system, positive regulation of protein autophosphorylation, regulation of transcription, DNA-dependent, two-component signal transduction system (phosphorelay)	cytoplasm	mitogen-activated protein kinase kinase kinase binding, protein homodimerization activity, protein kinase activator activity, two-component response regulator activity		
YLR007W	NSE1	Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomes [Source:SGD;Acc:S000003997]	DNA recombination, DNA repair, postreplication repair, response to DNA damage stimulus	Smc5-Smc6 complex, nucleus	metal ion binding, molecular_function		
YLR008C	PAM18	Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p [Source:SGD;Acc:S000003998]	protein import into mitochondrial matrix, protein transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial inner membrane presequence translocase complex, mitochondrion, presequence translocase-associated import motor	ATPase activator activity, heat shock protein binding, unfolded protein binding		
YLR009W	RLP24	Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis [Source:SGD;Acc:S000003999]	ribosomal large subunit biogenesis, ribosome biogenesis, translation	cytoplasm, intracellular, nucleolus, nucleus, preribosome, large subunit precursor, ribosome	molecular_function, structural constituent of ribosome		
YLR010C	TEN1	Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p [Source:SGD;Acc:S000004000]	negative regulation of telomere maintenance, telomere capping, telomere maintenance via telomerase	chromosome, telomeric region, nuclear telomere cap complex, nucleus	single-stranded telomeric DNA binding		
YLR011W	LOT6	FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions [Source:SGD;Acc:S000004001]	cellular response to oxidative stress, cytoplasmic sequestering of transcription factor, oxidation-reduction process	cytoplasm, cytosol, nucleus	FMN reductase activity, NAD(P)H dehydrogenase (quinone) activity, oxidoreductase activity, transcription factor binding		
YLR012C	YLR012C	Putative protein of unknown function; YLR012C is not an essential gene [Source:SGD;Acc:S000004002]	biological_process	cellular_component	molecular_function		
YLR013W	GAT3	Protein containing GATA family zinc finger motifs [Source:SGD;Acc:S000004003]	regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YLR014C	PPR1	Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p [Source:SGD;Acc:S000004004]	pyrimidine nucleotide biosynthetic process, regulation of transcription, DNA-dependent, uracil biosynthetic process	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YLR015W	BRE2	Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L [Source:SGD;Acc:S000004005]	chromatin silencing at telomere, histone H3-K4 methylation, telomere maintenance	Set1C/COMPASS complex, chromosome, telomeric region, nucleus	histone methyltransferase activity (H3-K4 specific)		
YLR016C	PML1	Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p [Source:SGD;Acc:S000004006]	RNA splicing, mRNA export from nucleus, mRNA processing, maintenance of RNA location, nuclear mRNA splicing, via spliceosome	RES complex, cytoplasm, nucleus	molecular_function, protein binding		
YLR017W	MEU1	Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression [Source:SGD;Acc:S000004007]	L-methionine salvage from methylthioadenosine, glutamate biosynthetic process, nucleoside metabolic process	cytoplasm	S-methyl-5-thioadenosine phosphorylase activity, catalytic activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring pentosyl groups		
YLR018C	POM34	Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex [Source:SGD;Acc:S000004008]	mRNA transport, nuclear pore organization, nucleocytoplasmic transport, protein transport, transmembrane transport, transport	NDC1 complex, integral to membrane, integral to organelle membrane, membrane, nuclear membrane, nuclear pore, nucleus	molecular_function		
YLR019W	PSR2	Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p [Source:SGD;Acc:S000004009]	response to stress	membrane, plasma membrane	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding		
YLR020C	YEH2	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism [Source:SGD;Acc:S000004010]	cell wall mannoprotein biosynthetic process, lipid catabolic process, lipid metabolic process, sterol metabolic process	integral to membrane, membrane, plasma membrane	hydrolase activity, sterol esterase activity		
YLR021W	IRC25	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions [Source:SGD;Acc:S000004011]	chaperone-mediated protein complex assembly, nuclear-transcribed mRNA catabolic process, non-stop decay, proteasome assembly	intracellular	molecular_function		
YLR022C	SDO1	Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes [Source:SGD;Acc:S000004012]	RNA metabolic process, rRNA processing, ribosomal large subunit biogenesis, ribosomal subunit export from nucleus, ribosome biogenesis	cytoplasm, nucleus, polysome, preribosome, large subunit precursor	molecular_function		
YLR023C	IZH3	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity [Source:SGD;Acc:S000004013]	cellular zinc ion homeostasis	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	metal ion binding		
YLR024C	UBR2	Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex [Source:SGD;Acc:S000004014]	protein monoubiquitination	cytoplasm	ligase activity, metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YLR025W	SNF7	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes [Source:SGD;Acc:S000004015]	cellular response to anoxia, intralumenal vesicle formation, late endosome to vacuole transport, protein transport, transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ESCRT III complex, cytoplasm, endosome, endosome membrane, membrane	protein binding		
YLR026C	SED5	cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins [Source:SGD;Acc:S000004016]	ER to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, protein transport, transport, vesicle fusion with Golgi apparatus, vesicle-mediated transport	Golgi apparatus, Golgi membrane, SNARE complex, cis-Golgi network, integral to membrane, membrane	SNAP receptor activity, protein binding		
YLR027C	AAT2	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells [Source:SGD;Acc:S000004017]	aspartate biosynthetic process, biosynthetic process, cellular amino acid metabolic process	cytoplasm, cytosol, peroxisome	L-aspartate:2-oxoglutarate aminotransferase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity, transferase activity, transferring nitrogenous groups		
YLR028C	ADE16	Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine [Source:SGD;Acc:S000004018]	'de novo' IMP biosynthetic process, IMP biosynthetic process, aerobic respiration, ascospore formation, purine nucleotide biosynthetic process	cytosol	IMP cyclohydrolase activity, catalytic activity, hydrolase activity, phosphoribosylaminoimidazolecarboxamide formyltransferase activity, transferase activity		
YLR029C	RPL15A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA [Source:SGD;Acc:S000004019]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YLR030W	YLR030W	Putative protein of unknown function [Source:SGD;Acc:S000004020]	biological_process	cellular_component	molecular_function		
YLR031W	YLR031W	Putative protein of unknown function [Source:SGD;Acc:S000004021]	biological_process	cellular_component	molecular_function		
YLR032W	RAD5	DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p [Source:SGD;Acc:S000004022]	DNA repair, double-strand break repair, free ubiquitin chain polymerization, postreplication repair, protein polyubiquitination, response to DNA damage stimulus	cytoplasm, nuclear chromatin, nucleus	ATP binding, DNA binding, DNA-dependent ATPase activity, Y-form DNA binding, four-way junction DNA binding, four-way junction helicase activity, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, metal ion binding, nucleic acid binding, nucleotide binding, protein binding, zinc ion binding		
YLR033W	RSC58	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance [Source:SGD;Acc:S000004023]	G1/S transition of mitotic cell cycle, chromatin modification, chromatin remodeling, nucleosome disassembly, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	molecular_function		
YLR034C	SMF3	Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins [Source:SGD;Acc:S000004024]	cellular iron ion homeostasis, ion transport, iron ion transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	metal ion binding, metal ion transmembrane transporter activity, transporter activity		
YLR035C	MLH2	Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p [Source:SGD;Acc:S000004025]	DNA repair, mismatch repair, reciprocal meiotic recombination, response to DNA damage stimulus	nucleus	ATP binding, mismatched DNA binding, molecular_function		
YLR035C-A	YLR035C-A	Retrotransposon TYA Gag and TYB Pol genes; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); YLR035C-A is part of a mutant retrotransposon [Source:SGD;Acc:S000007225]	DNA integration, transposition, RNA-mediated	retrotransposon nucleocapsid	DNA binding, RNA binding, nucleic acid binding		
YLR036C	YLR036C	Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein [Source:SGD;Acc:S000004026]	biological_process	cellular_component, integral to membrane, membrane	ATP binding, molecular_function, nucleotide binding		
YLR037C	PAU23	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth [Source:SGD;Acc:S000004027]	biological_process, cellular cell wall organization, response to stress	cell wall, extracellular region, fungal-type cell wall	molecular_function		
YLR038C	COX12	Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated [Source:SGD;Acc:S000004028]	mitochondrial respiratory chain complex IV assembly	mitochondrial respiratory chain complex IV, mitochondrion	cytochrome-c oxidase activity		
YLR039C	RIC1	Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes [Source:SGD;Acc:S000004029]	intracellular protein transport, retrograde transport, endosome to Golgi	Golgi apparatus, Golgi membrane, Ric1p-Rgp1p complex, guanyl-nucleotide exchange factor complex, membrane, nucleus	guanyl-nucleotide exchange factor activity		
YLR040C	YLR040C	Putative protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; YLR040C is not essential [Source:SGD;Acc:S000004030]	biological_process, response to stress	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YLR041W	YLR041W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C [Source:SGD;Acc:S000004031]					
YLR042C	YLR042C	Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene [Source:SGD;Acc:S000004032]	biological_process	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YLR043C	TRX1	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance [Source:SGD;Acc:S000004033]	ER to Golgi vesicle-mediated transport, cell redox homeostasis, cellular response to oxidative stress, deoxyribonucleotide biosynthetic process, electron transport chain, glycerol ether metabolic process, protein deglutathionylation, protein transport, regulation of DNA replication, retrograde vesicle-mediated transport, Golgi to ER, sulfate assimilation, transport, vacuole fusion, non-autophagic, vacuole inheritance	Golgi apparatus, Golgi membrane, cytoplasm, cytosol, fungal-type vacuole, membrane, nucleus	disulfide oxidoreductase activity, electron carrier activity, protein disulfide oxidoreductase activity		
YLR044C	PDC1	Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism [Source:SGD;Acc:S000004034]	L-phenylalanine catabolic process, aromatic amino acid family catabolic process to alcohol via Ehrlich pathway, branched chain family amino acid catabolic process, glucose catabolic process to ethanol, pyruvate metabolic process, tryptophan catabolic process	cytoplasm, cytosol, nucleus	carboxy-lyase activity, catalytic activity, lyase activity, magnesium ion binding, metal ion binding, pyruvate decarboxylase activity, thiamine pyrophosphate binding, transferase activity		
YLR045C	STU2	Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p [Source:SGD;Acc:S000004035]	microtubule nucleation, mitotic spindle organization in nucleus	cell cortex, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle, spindle microtubule, spindle pole body	binding, microtubule binding, structural constituent of cytoskeleton		
YLR046C	YLR046C	Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance [Source:SGD;Acc:S000004036]	biological_process, response to stress	integral to membrane, membrane	molecular_function		
YLR047C	FRE8	Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p [Source:SGD;Acc:S000004037]	cellular metal ion homeostasis, electron transport chain, ion transport, iron ion transport, oxidation-reduction process, transport	integral to membrane, membrane	electron carrier activity, ferric-chelate reductase activity, flavin adenine dinucleotide binding, iron ion binding, oxidoreductase activity, oxidoreductase activity, oxidizing metal ions		
YLR048W	RPS0B	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal [Source:SGD;Acc:S000004038]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA export from nucleus, rRNA processing, ribosomal small subunit assembly, ribosome biogenesis, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome, small ribosomal subunit	structural constituent of ribosome		
YLR049C	YLR049C	Putative protein of unknown function [Source:SGD;Acc:S000004039]	biological_process	cellular_component	molecular_function		
YLR050C	YLR050C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene [Source:SGD;Acc:S000004040]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YLR051C	FCF2	Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon [Source:SGD;Acc:S000004041]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus	molecular_function		
YLR052W	IES3	Subunit of the INO80 chromatin remodeling complex [Source:SGD;Acc:S000004042]	chromatin silencing at telomere, nucleosome mobilization, telomere maintenance	Ino80 complex, nucleus	molecular_function		
YLR053C	YLR053C	Putative protein of unknown function [Source:SGD;Acc:S000004043]	biological_process	cellular_component	molecular_function		
YLR054C	OSW2	Protein of unknown function proposed to be involved in the assembly of the spore wall [Source:SGD;Acc:S000004044]	ascospore wall assembly, sporulation resulting in formation of a cellular spore	cytoplasm, membrane, prospore membrane	molecular_function		
YLR055C	SPT8	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters [Source:SGD;Acc:S000004045]	chromatin modification, histone acetylation, negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter	SAGA complex, nucleus	TBP-class protein binding, protein binding, transcription cofactor activity		
YLR056W	ERG3	C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources [Source:SGD;Acc:S000004046]	ergosterol biosynthetic process, fatty acid biosynthetic process, lipid biosynthetic process, oxidation-reduction process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	C-5 sterol desaturase activity, iron ion binding, oxidoreductase activity		
YLR057W	YLR057W	Putative protein of unknown function; YLR050W is not an essential gene [Source:SGD;Acc:S000004047]	biological_process, metabolic process	cellular_component, integral to membrane, membrane	calcium ion binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity, molecular_function		
YLR058C	SHM2	Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis [Source:SGD;Acc:S000004048]	L-serine metabolic process, glycine metabolic process, one-carbon metabolic process	cytoplasm, mating projection tip, plasma membrane enriched fraction	catalytic activity, glycine hydroxymethyltransferase activity, pyridoxal phosphate binding, transferase activity		
YLR059C	REX2	3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease [Source:SGD;Acc:S000004049]	U4 snRNA 3'-end processing, U5 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), mitochondrial genome maintenance	intracellular, mitochondrion	3'-5' exonuclease activity, 3'-5'-exoribonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding		
YLR060W	FRS1	Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control [Source:SGD;Acc:S000004050]	phenylalanyl-tRNA aminoacylation, translation	cytoplasm, phenylalanine-tRNA ligase complex	ATP binding, RNA binding, aminoacyl-tRNA ligase activity, ligase activity, magnesium ion binding, nucleotide binding, phenylalanine-tRNA ligase activity		
YLR061W	RPL22A	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein [Source:SGD;Acc:S000004051]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YLR062C	BUD28	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay [Source:SGD;Acc:S000004052]					
YLR063W	YLR063W	Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene [Source:SGD;Acc:S000004053]	biological_process	cytoplasm	S-adenosylmethionine-dependent methyltransferase activity		
YLR064W	PER33	Putative protein of unknown function; localizes to the endoplasmic reticulum with some nuclear pore complex association; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; YLR064W is not an essential gene [Source:SGD;Acc:S000004054]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear pore	molecular_function		
YLR065C	YLR065C	Putative protein of unknown function; YLR065C is not an essential gene [Source:SGD;Acc:S000004055]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YLR066W	SPC3	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 [Source:SGD;Acc:S000004056]	protein targeting to ER, signal peptide processing	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, signal peptidase complex	peptidase activity		
YLR067C	PET309	Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs) [Source:SGD;Acc:S000004057]	RNA metabolic process, aerobic respiration, positive regulation of mitochondrial translational initiation	extrinsic to mitochondrial inner membrane, integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	translation regulator activity		
YLR068W	FYV7	Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin [Source:SGD;Acc:S000004058]	RNA processing, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing	nucleolus, nucleus	molecular_function		
YLR069C	MEF1	Mitochondrial elongation factor involved in translational elongation [Source:SGD;Acc:S000004059]	mitochondrial translation, mitochondrial translational elongation, translation, translational elongation	intracellular, mitochondrion	GTP binding, GTPase activity, nucleotide binding, translation elongation factor activity		
YLR070C	XYL2	Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect [Source:SGD;Acc:S000004060]	D-xylose metabolic process, carbohydrate metabolic process, metabolic process, oxidation-reduction process, xylulose biosynthetic process	cellular_component	D-xylulose reductase activity, binding, catalytic activity, metal ion binding, oxidoreductase activity, zinc ion binding		
YLR071C	RGR1	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation [Source:SGD;Acc:S000004061]	regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus			
YLR072W	YLR072W	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene [Source:SGD;Acc:S000004062]	biological_process	cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, integral to membrane, membrane	molecular_function		
YLR073C	RFU1	Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes [Source:SGD;Acc:S000004063]	regulation of ubiquitin homeostasis	endosome	cysteine-type endopeptidase inhibitor activity, enzyme inhibitor activity, peptidase inhibitor activity		
YLR074C	BUD20	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern [Source:SGD;Acc:S000004064]	cellular bud site selection	endoplasmic reticulum, intracellular, nucleus	metal ion binding, molecular_function, nucleic acid binding, zinc ion binding		
YLR075W	RPL10	Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family [Source:SGD;Acc:S000004065]	ribosomal large subunit assembly, translation, translational termination	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YLR076C	YLR076C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 [Source:SGD;Acc:S000004066]					
YLR077W	FMP25	Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria [Source:SGD;Acc:S000004067]	mitochondrial respiratory chain complex III assembly	integral to membrane, integral to mitochondrial inner membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YLR078C	BOS1	v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi [Source:SGD;Acc:S000004068]	ER to Golgi vesicle-mediated transport, protein transport, transport, vesicle fusion with Golgi apparatus, vesicle-mediated transport	ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, SNARE complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	SNAP receptor activity		
YLR079W	SIC1	Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 [Source:SGD;Acc:S000004069]	G1/S transition of mitotic cell cycle, negative regulation of macroautophagy, regulation of cyclin-dependent protein kinase activity	cytoplasm, nucleus	cyclin-dependent protein kinase inhibitor activity		
YLR080W	EMP46	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport [Source:SGD;Acc:S000004070]	ER to Golgi vesicle-mediated transport, protein transport, transport	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	glycoprotein binding, metal ion binding, sugar binding		
YLR081W	GAL2	Galactose permease, required for utilization of galactose; also able to transport glucose [Source:SGD;Acc:S000004071]	carbohydrate transport, galactose metabolic process, galactose transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	galactose transmembrane transporter activity, glucose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YLR082C	SRL2	Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation [Source:SGD;Acc:S000004072]	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	cytoplasm, nucleus	molecular_function		
YLR083C	EMP70	Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments [Source:SGD;Acc:S000004073]	cellular copper ion homeostasis, endosome transport, invasive growth in response to glucose limitation, pseudohyphal growth, vacuolar transport	endosome, endosome membrane, fungal-type vacuole membrane, integral to membrane, membrane	molecular_function		
YLR084C	RAX2	N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p [Source:SGD;Acc:S000004074]	cell cycle, cell division, cellular bud site selection	cellular bud neck, cellular bud scar, cellular bud tip, integral to membrane, membrane, mitochondrion, plasma membrane	molecular_function, protein binding		
YLR085C	ARP6	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A [Source:SGD;Acc:S000004075]	chromatin modification, chromatin remodeling, histone exchange	Swr1 complex, cytoplasm, nucleus	nucleosome binding		
YLR086W	SMC4	Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate [Source:SGD;Acc:S000004076]	cell cycle, cell division, chromosome condensation, chromosome organization, mitosis, mitotic chromosome condensation, mitotic sister chromatid segregation, tRNA gene clustering	SMC loading complex, chromosome, cytoplasm, nuclear condensin complex, nucleus	ATP binding, ATPase activity, chromatin binding, nucleotide binding, protein binding		
YLR087C	CSF1	Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004077]	fermentation	integral to membrane, membrane, mitochondrion	molecular_function		
YLR088W	GAA1	Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER [Source:SGD;Acc:S000004078]	GPI anchor biosynthetic process, attachment of GPI anchor to protein	GPI-anchor transamidase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	GPI-anchor transamidase activity		
YLR089C	ALT1	Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004079]	alanine biosynthetic process, alanine catabolic process, biosynthetic process	mitochondrial matrix, mitochondrion	1-aminocyclopropane-1-carboxylate synthase activity, L-alanine:2-oxoglutarate aminotransferase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity, transferase activity, transferring nitrogenous groups		
YLR090W	XDJ1	Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004080]	protein folding	integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion, nucleus	chaperone binding, heat shock protein binding, metal ion binding, unfolded protein binding		
YLR091W	GEP5	Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine [Source:SGD;Acc:S000004081]	mitochondrial genome maintenance	mitochondrion	molecular_function		
YLR092W	SUL2	High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates [Source:SGD;Acc:S000004082]	sulfate transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane, plasma membrane enriched fraction	secondary active sulfate transmembrane transporter activity, sulfate transmembrane transporter activity, transporter activity		
YLR093C	NYV1	v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane [Source:SGD;Acc:S000004083]	vacuole fusion, non-autophagic, vesicle fusion, vesicle-mediated transport	integral to membrane, membrane, vacuolar membrane, vacuole	SNAP receptor activity		
YLR094C	GIS3	Protein of unknown function [Source:SGD;Acc:S000004084]	intracellular signal transduction	cytoplasm, nucleus	molecular_function		
YLR095C	IOC2	Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif [Source:SGD;Acc:S000004085]	chromatin remodeling	ISW1 complex, nucleus	ATPase activity, DNA binding, nucleosome binding, protein binding		
YLR096W	KIN2	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p [Source:SGD;Acc:S000004086]	exocytosis, protein autophosphorylation, protein phosphorylation	cytoplasm, membrane, plasma membrane	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YLR097C	HRT3	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies [Source:SGD;Acc:S000004087]	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	ubiquitin-protein ligase activity		
YLR098C	CHA4	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain [Source:SGD;Acc:S000004088]	cellular amino acid catabolic process, positive regulation of transcription, DNA-dependent, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YLR099C	ICT1	Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress [Source:SGD;Acc:S000004089]	phosphatidic acid biosynthetic process, phospholipid biosynthetic process, response to stress	cellular_component	1-acylglycerol-3-phosphate O-acyltransferase activity, acyltransferase activity, lysophosphatidic acid acyltransferase activity, transferase activity		
YLR099W-A	YLR099W-A	Putative protein of unknown function [Source:SGD;Acc:S000007618]	biological_process	cellular_component	molecular_function		
YLR100W	ERG27	3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs [Source:SGD;Acc:S000004090]	ergosterol biosynthetic process, lipid biosynthetic process, metabolic process, oxidation-reduction process, steroid biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, lipid particle, membrane, mitochondrial outer membrane	3-keto sterol reductase activity, binding, catalytic activity, oxidoreductase activity		
YLR101C	YLR101C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W [Source:SGD;Acc:S000004091]					
YLR102C	APC9	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000004092]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, cyclin catabolic process, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, protein ubiquitination	anaphase-promoting complex, cytoplasm, nucleus	ubiquitin-protein ligase activity		
YLR103C	CDC45	DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes [Source:SGD;Acc:S000004093]	DNA replication, DNA-dependent DNA replication initiation, S phase of mitotic cell cycle, cell cycle, double-strand break repair via break-induced replication, pre-replicative complex assembly, regulation of chromatin silencing at telomere	DNA replication preinitiation complex, nuclear replication fork, nucleus, pre-replicative complex, replication fork protection complex	DNA replication origin binding, chromatin binding		
YLR104W	LCL2	Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD) [Source:SGD;Acc:S000004094]	ER-associated protein catabolic process	cellular_component	molecular_function		
YLR105C	SEN2	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease [Source:SGD;Acc:S000004095]	tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation, tRNA-type intron splice site recognition and cleavage	endomembrane system, membrane, mitochondrial outer membrane, mitochondrion, nucleus, tRNA-intron endonuclease complex	endonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, tRNA-intron endonuclease activity		
YLR106C	MDN1	Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus [Source:SGD;Acc:S000004096]	rRNA processing, regulation of protein complex assembly, regulation of transcription, DNA-dependent, ribosomal large subunit assembly	intracellular, mitochondrion, nucleoplasm, nucleus	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding, protein binding, transcription factor binding		
YLR107W	REX3	RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases [Source:SGD;Acc:S000004097]	U5 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ncRNA 3'-end processing, rRNA processing	cytoplasm, intracellular, nucleus	3'-5' exonuclease activity, 3'-5'-exoribonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding		
YLR108C	YLR108C	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene [Source:SGD;Acc:S000004098]	biological_process	nucleus	molecular_function, protein binding		
YLR109W	AHP1	Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p [Source:SGD;Acc:S000004099]	cell redox homeostasis, cellular response to oxidative stress, oxidation-reduction process, response to metal ion	cytoplasm, plasma membrane enriched fraction	antioxidant activity, oxidoreductase activity, peroxidase activity, peroxiredoxin activity, thioredoxin peroxidase activity		
YLR110C	CCW12	Cell wall mannoprotein with a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip [Source:SGD;Acc:S000004100]	agglutination involved in conjugation with cellular fusion, cellular cell wall organization, conjugation with cellular fusion, fungal-type cell wall organization	anchored to membrane, cell wall, cellular bud tip, extracellular region, fungal-type cell wall, mating projection tip, membrane	molecular_function		
YLR111W	YLR111W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004101]					
YLR112W	YLR112W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004102]					
YLR113W	HOG1	Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p [Source:SGD;Acc:S000004103]	hyperosmotic response, negative regulation of transcription from RNA polymerase II promoter by pheromones, osmosensory signaling pathway, positive regulation of transcription from RNA polymerase II promoter, protein phosphorylation, response to arsenic-containing substance	cytoplasm, nucleus	ATP binding, MAP kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YLR114C	AVL9	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms [Source:SGD;Acc:S000004104]	post-Golgi vesicle-mediated transport	cytoplasm	molecular_function		
YLR115W	CFT2	Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. [Source:SGD;Acc:S000004105]	mRNA cleavage, mRNA polyadenylation, mRNA processing	mRNA cleavage and polyadenylation specificity factor complex, mRNA cleavage factor complex, nucleus	RNA binding		
YLR116W	MSL5	Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA [Source:SGD;Acc:S000004106]	RNA splicing, intracellular protein transport, mRNA processing, nuclear mRNA splicing, via spliceosome, vesicle-mediated transport	commitment complex, membrane coat, nucleus	RNA binding, metal ion binding, nucleic acid binding, pre-mRNA branch point binding, zinc ion binding		
YLR117C	CLF1	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins [Source:SGD;Acc:S000004107]	DNA-dependent DNA replication initiation, RNA processing, RNA splicing, cell cycle, cis assembly of pre-catalytic spliceosome, mRNA processing	Prp19 complex, U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, U2-type post-mRNA release spliceosomal complex, U2-type prespliceosome, chromatin, intracellular, nucleus, spliceosomal complex	DNA replication origin binding, binding, chromatin binding, first spliceosomal transesterification activity, protein binding, second spliceosomal transesterification activity		
YLR118C	YLR118C	Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000004108]	fatty acid metabolic process, lipid metabolic process, protein deacylation	cytoplasm, nucleus	carboxylesterase activity, hydrolase activity, palmitoyl-(protein) hydrolase activity		
YLR119W	SRN2	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus [Source:SGD;Acc:S000004109]	protein targeting to membrane, protein targeting to vacuole, protein transport, transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ESCRT I complex, cytoplasm, endosome, late endosome membrane, membrane	protein binding		
YLR120C	YPS1	Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor [Source:SGD;Acc:S000004110]	fungal-type cell wall organization, protein processing, proteolysis	anchored to membrane, fungal-type cell wall, membrane, plasma membrane	aspartic-type endopeptidase activity, hydrolase activity, peptidase activity		
YLR120W-A	YLR120W-A	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ORF YLR121C [Source:SGD;Acc:S000028674]					
YLR121C	YPS3	Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor [Source:SGD;Acc:S000004111]	cellular protein metabolic process, fungal-type cell wall organization, proteolysis	anchored to membrane, anchored to plasma membrane, membrane, plasma membrane	aspartic-type endopeptidase activity, hydrolase activity, peptidase activity, structural constituent of cell wall		
YLR122C	YLR122C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C [Source:SGD;Acc:S000004112]					
YLR123C	YLR123C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif [Source:SGD;Acc:S000004113]					
YLR124W	YLR124W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004114]					
YLR125W	YLR125W	Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene [Source:SGD;Acc:S000004115]	biological_process	cellular_component	molecular_function		
YLR126C	YLR126C	Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein [Source:SGD;Acc:S000004116]	cellular copper ion homeostasis, cellular iron ion homeostasis, glutamine metabolic process	cytoplasm	catalytic activity, molecular_function, transferase activity		
YLR127C	APC2	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p [Source:SGD;Acc:S000004117]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, cyclin catabolic process, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, protein ubiquitination, ubiquitin-dependent protein catabolic process	anaphase-promoting complex, cullin-RING ubiquitin ligase complex, cytoplasm, nucleus	ubiquitin protein ligase binding, ubiquitin-protein ligase activity		
YLR128W	DCN1	Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation [Source:SGD;Acc:S000004118]	positive regulation of ubiquitin-protein ligase activity, protein neddylation	cellular_component	NEDD8 ligase activity, protein binding, small conjugating protein binding, ubiquitin binding		
YLR129W	DIP2	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex [Source:SGD;Acc:S000004119]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, Pwp2p-containing subcomplex of 90S preribosome, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	protein binding, snoRNA binding		
YLR130C	ZRT2	Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor [Source:SGD;Acc:S000004120]	ion transport, low-affinity zinc ion transport, metal ion transport, transmembrane transport, transport, zinc ion transport	integral to membrane, membrane, plasma membrane	low-affinity zinc ion transmembrane transporter activity, metal ion transmembrane transporter activity, zinc ion transmembrane transporter activity		
YLR131C	ACE2	Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate [Source:SGD;Acc:S000004121]	regulation of transcription involved in G1 phase of mitotic cell cycle	cytosol, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YLR132C	YLR132C	Essential protein of unknown function; fluorescent protein (GFP or YFP)-tagged protein localizes to mitochondria, cytoplasm and nucleus [Source:SGD;Acc:S000004122]	RNA splicing, biological_process, mRNA processing	cytoplasm, mitochondrion, nucleus	molecular_function		
YLR133W	CKI1	Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway [Source:SGD;Acc:S000004123]	phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process	cytoplasm	ATP binding, choline kinase activity, ethanolamine kinase activity, kinase activity, nucleotide binding, transferase activity		
YLR134W	PDC5	Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism [Source:SGD;Acc:S000004124]	L-phenylalanine catabolic process, aromatic amino acid family catabolic process to alcohol via Ehrlich pathway, branched chain family amino acid catabolic process, glucose catabolic process to ethanol, pyruvate metabolic process, tryptophan catabolic process	cytoplasm, nucleus	carboxy-lyase activity, catalytic activity, lyase activity, magnesium ion binding, metal ion binding, pyruvate decarboxylase activity, thiamine pyrophosphate binding, transferase activity		
YLR135W	SLX4	Endonuclease involved in processing DNA during recombination and repair; cleaves branched structures in a complex with Slx1p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing [Source:SGD;Acc:S000004125]	DNA recombination, DNA repair, DNA replication, DNA-dependent DNA replication, double-strand break repair via single-strand annealing, removal of nonhomologous ends, response to DNA damage stimulus	Slx1-Slx4 complex, cytoplasm, nucleus	5'-flap endonuclease activity		
YLR136C	TIS11	mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis [Source:SGD;Acc:S000004126]	cellular iron ion homeostasis, nuclear-transcribed mRNA catabolic process	cytoplasm, cytoplasmic mRNA processing body, nucleus	RNA binding, mRNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YLR137W	YLR137W	Putative S-adenosylmethionine-dependent methyltransferase [Source:SGD;Acc:S000004127]	biological_process	cellular_component	S-adenosylmethionine-dependent methyltransferase activity		
YLR138W	NHA1	Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH [Source:SGD;Acc:S000004128]	cation transport, cellular monovalent inorganic cation homeostasis, cellular potassium ion homeostasis, ion transport, response to osmotic stress, sodium ion transport, transmembrane transport, transport	integral to membrane, membrane, membrane raft, plasma membrane	antiporter activity, cation:cation antiporter activity, sodium:hydrogen antiporter activity, solute:hydrogen antiporter activity		
YLR139C	SLS1	Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery [Source:SGD;Acc:S000004129]	aerobic respiration, mitochondrial translation, translation	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrion	molecular_function		
YLR140W	YLR140W	Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I [Source:SGD;Acc:S000004130]					
YLR141W	RRN5	Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p [Source:SGD;Acc:S000004131]	transcription from RNA polymerase I promoter, transcription of nuclear rRNA large RNA polymerase I transcript	RNA polymerase I upstream activating factor complex, nucleolus, nucleus	rDNA binding		
YLR142W	PUT1	Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source [Source:SGD;Acc:S000004132]	glutamate biosynthetic process, oxidation-reduction process, proline catabolic process, proline catabolic process to glutamate, proline metabolic process	mitochondrial matrix, mitochondrion	oxidoreductase activity, proline dehydrogenase activity		
YLR143W	YLR143W	Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene [Source:SGD;Acc:S000004133]	biological_process	cytoplasm	endonuclease activity, hydrolase activity, molecular_function, nuclease activity		
YLR144C	ACF2	Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly [Source:SGD;Acc:S000004134]	actin cytoskeleton organization, cell wall macromolecule catabolic process, metabolic process	cytoplasm, intracellular	endo-1,3(4)-beta-glucanase activity, glucan endo-1,3-beta-D-glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds		
YLR145W	RMP1	Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P [Source:SGD;Acc:S000004135]	mRNA cleavage, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing	cytoplasm, integral to membrane, membrane, nucleolus, nucleus, ribonuclease MRP complex	ribonuclease MRP activity		
YLR146C	SPE4	Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid [Source:SGD;Acc:S000004136]	pantothenate biosynthetic process, spermine biosynthetic process	cytoplasm	catalytic activity, spermine synthase activity, transferase activity		
YLR146W-A	YLR146W-A	Putative protein of unknown function [Source:SGD;Acc:S000113566]	biological_process	cellular_component	molecular_function		
YLR147C	SMD3	Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 [Source:SGD;Acc:S000004137]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, commitment complex, cytoplasm, nucleus, ribonucleoprotein complex	RNA binding, mRNA binding		
YLR148W	PEP3	Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis [Source:SGD;Acc:S000004138]	Golgi to endosome transport, intracellular protein transport, late endosome to vacuole transport, protein transport, regulation of SNARE complex assembly, regulation of vacuole fusion, non-autophagic, transport, vacuole fusion, non-autophagic, vesicle docking involved in exocytosis, vesicle-mediated transport	CORVET complex, HOPS complex, extrinsic to vacuolar membrane, fungal-type vacuole membrane, membrane, proteasome storage granule, vacuolar membrane, vacuole	metal ion binding, phosphatidylinositol binding, protein binding, zinc ion binding		
YLR149C	YLR149C	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene [Source:SGD;Acc:S000004139]	biological_process	cellular_component	molecular_function, protein binding		
YLR149C-A	YLR149C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007619]					
YLR150W	STM1	Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure [Source:SGD;Acc:S000004140]	TOR signaling cascade, anti-apoptosis, regulation of translational initiation in response to stress, telomere maintenance, translational elongation	cytoplasm, cytosolic ribosome, nucleus, perinuclear region of cytoplasm, polysome	DNA binding, telomeric DNA binding, triplex DNA binding		
YLR151C	PCD1	Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids [Source:SGD;Acc:S000004141]	biological_process, nucleoside diphosphate metabolic process	peroxisome	hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, magnesium ion binding, manganese ion binding, metal ion binding, pyrophosphatase activity		
YLR152C	YLR152C	Putative protein of unknown function; YLR152C is not an essential gene [Source:SGD;Acc:S000004142]	biological_process, transmembrane transport, transport	cellular_component, integral to membrane, membrane	molecular_function		
YLR153C	ACS2	Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions [Source:SGD;Acc:S000004143]	acetyl-CoA biosynthetic process, histone acetylation, metabolic process, replicative cell aging	cytoplasm, cytosol, nucleolus, nucleus	AMP binding, ATP binding, acetate-CoA ligase activity, catalytic activity, ligase activity, nucleotide binding		
YLR154C	RNH203	Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome [Source:SGD;Acc:S000004144]	DNA replication, removal of RNA primer, RNA catabolic process	cytoplasm, nucleus, ribonuclease H2 complex	ribonuclease H activity		
YLR154C-G	YLR154C-G	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2 [Source:SGD;Acc:S000028561]	biological_process	cellular_component	molecular_function		
YLR154C-H	YLR154C-H	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-2 [Source:SGD;Acc:S000028562]	biological_process	cellular_component	molecular_function		
YLR154W-A	YLR154W-A	Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand [Source:SGD;Acc:S000028675]					
YLR154W-B	YLR154W-B	Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand [Source:SGD;Acc:S000028563]					
YLR154W-C	TAR1	Mitochondrial protein potentially involved in regulation of respiratory metabolism; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand [Source:SGD;Acc:S000028422]	regulation of cellular respiration	mitochondrion	molecular_function		
YLR154W-E	YLR154W-E	Dubious open reading frame unlikely to encode a protein; encoded within the the 35S rRNA gene on the opposite strand [Source:SGD;Acc:S000028676]					
YLR154W-F	YLR154W-F	Dubious open reading frame unlikely to encode a protein; encoded within the the 35S rRNA gene on the opposite strand [Source:SGD;Acc:S000028843]					
YLR155C	ASP3-1	Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3 [Source:SGD;Acc:S000004145]	asparagine catabolic process, asparagine metabolic process, cellular amino acid metabolic process, cellular response to nitrogen starvation	cell wall, cell wall-bounded periplasmic space, endoplasmic reticulum, extracellular region, nuclear envelope	asparaginase activity, hydrolase activity		
YLR156C-A	YLR156C-A	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-3 [Source:SGD;Acc:S000028564]	biological_process	cellular_component	molecular_function		
YLR156W	YLR156W	Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis [Source:SGD;Acc:S000004146]	biological_process	cellular_component	molecular_function		
YLR157C	ASP3-2	Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3 [Source:SGD;Acc:S000004147]	asparagine catabolic process, asparagine metabolic process, cellular amino acid metabolic process, cellular response to nitrogen starvation	cell wall, cell wall-bounded periplasmic space, extracellular region	asparaginase activity, hydrolase activity		
YLR157C-A	YLR157C-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007373]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YLR157C-B	YLR157C-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007374]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YLR157C-C	YLR157C-C	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-4 [Source:SGD;Acc:S000028565]	biological_process	cellular_component	molecular_function		
YLR157W-D	YLR157W-D	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028677]	biological_process	cellular_component	molecular_function		
YLR157W-E	YLR157W-E	Putative protein of unknown function identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element [Source:SGD;Acc:S000028678]	biological_process	cellular_component	molecular_function		
YLR158C	ASP3-3	Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3 [Source:SGD;Acc:S000004148]	asparagine catabolic process, asparagine metabolic process, cellular amino acid metabolic process, cellular response to nitrogen starvation	cell wall, cell wall-bounded periplasmic space, extracellular region	asparaginase activity, hydrolase activity		
YLR159C-A	YLR159C-A	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-5 [Source:SGD;Acc:S000028566]	biological_process	cellular_component	molecular_function		
YLR159W	YLR159W	Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12 [Source:SGD;Acc:S000004149]	biological_process	cellular_component	molecular_function		
YLR160C	ASP3-4	Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3 [Source:SGD;Acc:S000004150]	asparagine catabolic process, asparagine metabolic process, cellular amino acid metabolic process, cellular response to nitrogen starvation	cell wall, cell wall-bounded periplasmic space, extracellular region	asparaginase activity, hydrolase activity		
YLR161W	YLR161W	Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12 [Source:SGD;Acc:S000004151]	biological_process	cellular_component	molecular_function		
YLR162W	YLR162W	Putative protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest, apoptosis, and increased sensitivity to cobalt chloride [Source:SGD;Acc:S000004152]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YLR162W-A	RRT15	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription [Source:SGD;Acc:S000028567]	biological_process	cellular_component	molecular_function		
YLR163C	MAS1	Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins [Source:SGD;Acc:S000004153]	protein processing involved in protein targeting to mitochondrion, proteolysis	mitochondrial matrix, mitochondrial processing peptidase complex, mitochondrion	catalytic activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding		
YLR163W-A	YLR163W-A	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000028844]					
YLR164W	YLR164W	Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner [Source:SGD;Acc:S000004154]	biological_process, electron transport chain, transport, tricarboxylic acid cycle	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion	heme binding, iron ion binding, metal ion binding, molecular_function		
YLR165C	PUS5	Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability [Source:SGD;Acc:S000004155]	RNA modification, pseudouridine synthesis, rRNA modification, rRNA processing	mitochondrion	RNA binding, isomerase activity, pseudouridine synthase activity, pseudouridylate synthase activity		
YLR166C	SEC10	Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis [Source:SGD;Acc:S000004156]	Golgi to plasma membrane transport, bipolar cellular bud site selection, cytokinesis, establishment of cell polarity, exocytosis, protein transport, transport, vesicle docking, vesicle docking involved in exocytosis, vesicle fusion	cytoplasm, exocyst, mating projection tip	molecular_function		
YLR167W	RPS31	Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B [Source:SGD;Acc:S000004157]	DNA repair, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S), response to DNA damage stimulus, ribosomal small subunit assembly, ribosome biogenesis, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, nucleus, ribonucleoprotein complex, ribosome	metal ion binding, protein binding, protein tag, structural constituent of ribosome		
YLR168C	UPS2	Mitochondrial intermembrane space protein involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI [Source:SGD;Acc:S000004158]	cardiolipin metabolic process, cristae formation, phosphatidylethanolamine metabolic process	extrinsic to mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion	molecular_function		
YLR169W	YLR169W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004159]					
YLR170C	APS1	Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex [Source:SGD;Acc:S000004160]	Golgi to vacuole transport, intracellular protein transport, protein transport, transport, vesicle-mediated transport	AP-1 adaptor complex, Golgi apparatus, clathrin adaptor complex, clathrin coat of trans-Golgi network vesicle, coated pit, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, membrane coat	clathrin binding, protein transporter activity		
YLR171W	YLR171W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004161]					
YLR172C	DPH5	Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000004162]	metabolic process, peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm	diphthine synthase activity, methyltransferase activity, transferase activity		
YLR173W	YLR173W	Putative protein of unknown function [Source:SGD;Acc:S000004163]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YLR174W	IDP2	Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose [Source:SGD;Acc:S000004164]	glutamate biosynthetic process, glyoxylate cycle, isocitrate metabolic process, oxidation-reduction process, tricarboxylic acid cycle	cytoplasm, cytosol	NAD binding, isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YLR175W	CBF5	Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita [Source:SGD;Acc:S000004165]	RNA modification, RNA processing, box H/ACA snoRNA 3'-end processing, cell cycle, cell division, mitosis, pseudouridine synthesis, rRNA processing, rRNA pseudouridine synthesis, ribosome biogenesis, snRNA pseudouridine synthesis	90S preribosome, box H/ACA snoRNP complex, chromosome, centromeric region, cytoplasm, cytoskeleton, microtubule, nucleolus, nucleus, ribonucleoprotein complex	DNA binding, RNA binding, isomerase activity, pseudouridine synthase activity		
YLR176C	RFX1	Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins [Source:SGD;Acc:S000004166]	negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	cytoplasm, nucleus	DNA binding, sequence-specific DNA binding		
YLR177W	YLR177W	Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene [Source:SGD;Acc:S000004167]	biological_process	cytoplasm	molecular_function		
YLR178C	TFS1	Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase [Source:SGD;Acc:S000004168]	regulation of Ras protein signal transduction, regulation of proteolysis	cytoplasm, fungal-type vacuole lumen, fungal-type vacuole membrane	lipid binding, peptidase inhibitor activity, phospholipid binding, serine-type endopeptidase inhibitor activity		
YLR179C	YLR179C	Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000004169]	biological_process	cytoplasm, nucleus	molecular_function		
YLR180W	SAM1	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) [Source:SGD;Acc:S000004170]	S-adenosylmethionine biosynthetic process, methionine metabolic process, one-carbon metabolic process	cytoplasm	ATP binding, metal ion binding, methionine adenosyltransferase activity, nucleotide binding, transferase activity		
YLR181C	VTA1	Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain [Source:SGD;Acc:S000004171]	late endosome to vacuole transport, late endosome to vacuole transport via multivesicular body sorting pathway, lipid transport, positive regulation of protein oligomerization, protein transport, transport	cytoplasm, endosome, endosome membrane, membrane, membrane fraction, multivesicular body	ATPase activator activity		
YLR182W	SWI6	Transcription cofactor, forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization [Source:SGD;Acc:S000004172]	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response, meiosis, regulation of transcription involved in G1/S phase of mitotic cell cycle	MBF transcription complex, SBF transcription complex, cytoplasm, nucleus	DNA binding, protein binding, transcription coactivator activity		
YLR183C	TOS4	Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; similar to PLM2 [Source:SGD;Acc:S000004173]	response to DNA damage stimulus	Rpd3L-Expanded complex, cytoplasm, mitochondrion, nuclear chromatin, nucleus	chromatin binding, protein binding		
YLR184W	YLR184W	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004174]					
YLR185W	RPL37A	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein [Source:SGD;Acc:S000004175]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, metal ion binding, rRNA binding, structural constituent of ribosome		
YLR186W	EMG1	Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers [Source:SGD;Acc:S000004176]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis	90S preribosome, cytoplasm, nuclear microtubule, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	RNA binding, protein homodimerization activity		
YLR187W	SKG3	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p [Source:SGD;Acc:S000004177]	biological_process	cellular bud, cellular bud neck, cytoplasm, membrane, plasma membrane	molecular_function, protein binding		
YLR188W	MDL1	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress [Source:SGD;Acc:S000004178]	oligopeptide export from mitochondrion, oligopeptide transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding, oligopeptide-transporting ATPase activity		
YLR189C	ATG26	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy [Source:SGD;Acc:S000004179]	ascospore-type prospore membrane assembly, autophagy, carbohydrate metabolic process, lipid biosynthetic process, lipid glycosylation, metabolic process, protein transport, steroid biosynthetic process, sterol biosynthetic process, sterol metabolic process, transport	cytoplasm, membrane	protein binding, sterol 3-beta-glucosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups		
YLR190W	MMR1	Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p [Source:SGD;Acc:S000004180]	cell cycle, cell division, mitochondrion inheritance	cellular bud, cellular bud neck, cellular bud tip, incipient cellular bud site, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YLR191W	PEX13	Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p [Source:SGD;Acc:S000004181]	protein import into peroxisome matrix, docking, protein transport, transport	integral to membrane, membrane, peroxisomal membrane, peroxisome	protein binding, protein binding, bridging		
YLR192C	HCR1	Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA [Source:SGD;Acc:S000004182]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	cytoplasm, eukaryotic translation initiation factor 3 complex	rRNA binding, translation initiation factor activity		
YLR193C	UPS1	Mitochondrial intermembrane space protein that regulates mitochondrial cardiolipin levels, null has defects in Mgm1p processing, integrity of mitochondrial inner membrane complexes, and mitochondrial morphology; ortholog of human PRELI [Source:SGD;Acc:S000004183]	cardiolipin metabolic process	extrinsic to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion	molecular_function		
YLR194C	YLR194C	Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress [Source:SGD;Acc:S000004184]	cellular cell wall organization, fungal-type cell wall organization	anchored to membrane, anchored to plasma membrane, fungal-type cell wall, membrane, plasma membrane	structural constituent of cell wall		
YLR195C	NMT1	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction [Source:SGD;Acc:S000004185]	N-terminal peptidyl-glycine N-myristoylation, N-terminal protein myristoylation, replicative cell aging	cytoplasm, cytosol	acyltransferase activity, glycylpeptide N-tetradecanoyltransferase activity, transferase activity		
YLR196W	PWP1	Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily [Source:SGD;Acc:S000004186]	rRNA processing	cytoplasm, nucleolus, nucleus	molecular_function, protein binding		
YLR197W	NOP56	Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects [Source:SGD;Acc:S000004187]	rRNA modification, rRNA processing, ribosome biogenesis	90S preribosome, box C/D snoRNP complex, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	molecular_function		
YLR198C	YLR198C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W [Source:SGD;Acc:S000004188]					
YLR199C	PBA1	Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly [Source:SGD;Acc:S000004189]	proteasome assembly	cytoplasm	molecular_function		
YLR200W	YKE2	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin [Source:SGD;Acc:S000004190]	protein folding, tubulin complex assembly	cytoplasm, nucleus, prefoldin complex	tubulin binding, unfolded protein binding		
YLR201C	COQ9	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes [Source:SGD;Acc:S000004191]	aerobic respiration, ubiquinone biosynthetic process	membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YLR202C	YLR202C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron [Source:SGD;Acc:S000004192]					
YLR203C	MSS51	Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase [Source:SGD;Acc:S000004193]	RNA splicing, mRNA processing, positive regulation of mitochondrial translation	extrinsic to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion	translation regulator activity		
YLR204W	QRI5	Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA [Source:SGD;Acc:S000004194]	mRNA processing	integral to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YLR205C	HMX1	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants [Source:SGD;Acc:S000004195]	cellular iron ion homeostasis, heme catabolic process, heme oxidation, oxidation-reduction process, response to oxidative stress	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear outer membrane	heme oxygenase (decyclizing) activity, metal ion binding		
YLR206W	ENT2	Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus [Source:SGD;Acc:S000004196]	actin cortical patch assembly, actin filament organization, endocytosis	actin cortical patch, cytoplasm, mating projection tip, membrane	clathrin binding, lipid binding		
YLR207W	HRD3	Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events [Source:SGD;Acc:S000004197]	ER-associated protein catabolic process	Hrd1p ubiquitin ligase ERAD-L complex, Hrd1p ubiquitin ligase ERAD-M complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, luminal surveillance complex, membrane	binding, ubiquitin-protein ligase activity		
YLR208W	SEC13	Component of both the Nup84 nuclear pore sub-complex and the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport and nuclear pore complex organization [Source:SGD;Acc:S000004198]	COPII-coated vesicle budding, mRNA transport, membrane budding, nuclear pore organization, positive regulation of GTPase activity, protein transport, transmembrane transport, transport, vesicle-mediated transport	COPII vesicle coat, ER to Golgi transport vesicle membrane, Nup107-160 complex, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear pore, nucleus	protein binding, structural molecule activity		
YLR209C	PNP1	Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway [Source:SGD;Acc:S000004199]	NAD biosynthesis via nicotinamide riboside salvage pathway, guanosine catabolic process, inosine catabolic process, nicotinate nucleotide salvage, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, nucleoside metabolic process	intracellular	catalytic activity, inosine nucleosidase activity, nicotinamide riboside hydrolase activity, purine-nucleoside phosphorylase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring pentosyl groups		
YLR210W	CLB4	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation [Source:SGD;Acc:S000004200]	G2/M transition of mitotic cell cycle, S phase of mitotic cell cycle, cell cycle, cell division, mitosis, positive regulation of spindle pole body separation, regulation of cyclin-dependent protein kinase activity	cytoplasm, nucleus, spindle pole body	cyclin-dependent protein kinase regulator activity		
YLR211C	YLR211C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron [Source:SGD;Acc:S000004201]	biological_process	cytoplasm	molecular_function		
YLR212C	TUB4	Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body [Source:SGD;Acc:S000004202]	microtubule nucleation, microtubule-based process, mitotic spindle organization in nucleus, protein polymerization	cytoplasm, cytoskeleton, gamma-tubulin small complex, spindle pole body, inner plaque of spindle pole body, microtubule, nucleus, outer plaque of spindle pole body, protein complex, spindle pole body	GTP binding, GTPase activity, nucleotide binding, structural constituent of cytoskeleton		
YLR213C	CRR1	Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation [Source:SGD;Acc:S000004203]	ascospore wall assembly, carbohydrate metabolic process, metabolic process, sporulation resulting in formation of a cellular spore	ascospore wall, spore wall	hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds		
YLR214W	FRE1	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels [Source:SGD;Acc:S000004204]	copper ion import, copper ion transport, electron transport chain, ion transport, iron ion transport, oxidation-reduction process, transport	integral to membrane, membrane, membrane fraction, plasma membrane	electron carrier activity, ferric-chelate reductase activity, flavin adenine dinucleotide binding, iron ion binding, metal ion binding, oxidoreductase activity		
YLR215C	CDC123	Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein [Source:SGD;Acc:S000004205]	cell cycle, cell division, regulation of mitotic cell cycle, regulation of translation	cytoplasm	molecular_function		
YLR216C	CPR6	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity [Source:SGD;Acc:S000004206]	protein folding, protein refolding	cytoplasm	binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity, protein binding, unfolded protein binding		
YLR217W	YLR217W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6 [Source:SGD;Acc:S000004207]					
YLR218C	COA4	Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors [Source:SGD;Acc:S000004208]	mitochondrial respiratory chain complex IV assembly, mitochondrial respiratory chain complex assembly	cytoplasm, mitochondrial intermembrane space, nucleus	molecular_function		
YLR219W	MSC3	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate [Source:SGD;Acc:S000004209]	DNA recombination, meiosis, reciprocal meiotic recombination	cellular_component, membrane, plasma membrane	molecular_function		
YLR220W	CCC1	Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation [Source:SGD;Acc:S000004210]	cellular calcium ion homeostasis, cellular iron ion homeostasis, cellular manganese ion homeostasis, ferrous iron transport, manganese ion transport, transport	Golgi apparatus, Golgi membrane, fungal-type vacuole membrane, integral to membrane, membrane, membrane fraction, vacuolar membrane, vacuole	ferrous iron transmembrane transporter activity, manganese ion transmembrane transporter activity		
YLR221C	RSA3	Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus [Source:SGD;Acc:S000004211]	ribosomal large subunit assembly, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor, ribonucleoprotein complex	molecular_function		
YLR222C	UTP13	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000004212]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, Pwp2p-containing subcomplex of 90S preribosome, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	protein binding, snoRNA binding		
YLR222C-A	YLR222C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene IFH1 [Source:SGD;Acc:S000028568]					
YLR223C	IFH1	Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing [Source:SGD;Acc:S000004213]	chromatin silencing at telomere, positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter, transcription from RNA polymerase III promoter	CURI complex, nuclear chromatin, nucleolus, nucleus	sequence-specific DNA binding transcription factor activity, transcription coactivator activity		
YLR224W	YLR224W	F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene [Source:SGD;Acc:S000004214]	ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding		
YLR225C	YLR225C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene [Source:SGD;Acc:S000004215]	biological_process, response to oxidative stress	cytoplasm	molecular_function		
YLR226W	BUR2	Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II [Source:SGD;Acc:S000004216]	cell cycle, mitotic sister chromatid segregation, phosphorylation of RNA polymerase II C-terminal domain, positive regulation of histone H3-K4 methylation, positive regulation of histone ubiquitination, response to DNA damage stimulus	cyclin-dependent protein kinase holoenzyme complex, nucleus	cyclin-dependent protein kinase regulator activity		
YLR227C	ADY4	Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane [Source:SGD;Acc:S000004217]	cell cycle, cell division, meiosis, sporulation resulting in formation of a cellular spore	cytoplasm, cytoskeleton, nucleus, spindle pole body	structural molecule activity		
YLR227W-A	YLR227W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007375]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YLR227W-B	YLR227W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007376]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YLR228C	ECM22	Sterol regulatory element binding protein, regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; homologous to Upc2p; relocates from intracellular membranes to perinuclear foci on sterol depletion [Source:SGD;Acc:S000004218]	regulation of transcription, DNA-dependent, sterol biosynthetic process	cytoplasm, membrane, nucleus, perinuclear region of cytoplasm	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YLR229C	CDC42	Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins [Source:SGD;Acc:S000004219]	Rho protein signal transduction, budding cell apical bud growth, budding cell isotropic bud growth, cell cycle, cell division, establishment of cell polarity, invasive growth in response to glucose limitation, pheromone-dependent signal transduction involved in conjugation with cellular fusion, positive regulation of exocytosis, pseudohyphal growth, regulation of exit from mitosis, regulation of initiation of mating projection growth, regulation of vacuole fusion, non-autophagic, response to pheromone, small GTPase mediated signal transduction	cellular bud neck, cellular bud tip, intracellular, mating projection tip, membrane, plasma membrane, soluble fraction	GTP binding, GTPase activity, nucleotide binding, signal transducer activity		
YLR230W	YLR230W	Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity [Source:SGD;Acc:S000004220]					
YLR231C	BNA5	Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p [Source:SGD;Acc:S000004221]	NAD biosynthetic process, de novo NAD biosynthetic process from tryptophan, metabolic process, pyridine nucleotide biosynthetic process, tryptophan catabolic process	cytoplasm, nucleus	catalytic activity, hydrolase activity, kynureninase activity, pyridoxal phosphate binding		
YLR232W	YLR232W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5 [Source:SGD;Acc:S000004222]					
YLR233C	EST1	TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA [Source:SGD;Acc:S000004223]	G-quadruplex DNA formation, telomere maintenance, telomere maintenance via telomerase	chromosome, telomeric region, nucleolus, nucleus, telomerase holoenzyme complex	DNA binding, RNA binding, RNA-directed DNA polymerase activity, nucleotidyltransferase activity, single-stranded DNA binding, telomeric DNA binding, transferase activity		
YLR234W	TOP3	DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination [Source:SGD;Acc:S000004224]	DNA metabolic process, DNA topological change, DNA unwinding involved in replication, mitotic sister chromatid cohesion, reciprocal meiotic recombination, regulation of DNA recombination, telomere maintenance via telomerase	RecQ helicase-Topo III complex, chromosome, nucleus	ATP binding, DNA binding, DNA topoisomerase activity, DNA topoisomerase type I activity, isomerase activity, nucleic acid binding, nucleotide binding		
YLR235C	YLR235C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3 [Source:SGD;Acc:S000004225]					
YLR236C	YLR236C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004226]					
YLR237W	THI7	Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia [Source:SGD;Acc:S000004227]	nucleobase, nucleoside, nucleotide and nucleic acid transport, thiamine transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	nucleobase transmembrane transporter activity, thiamine transmembrane transporter activity		
YLR238W	FAR10	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate [Source:SGD;Acc:S000004228]	cell cycle, re-entry into mitotic cell cycle after pheromone arrest	endoplasmic reticulum, integral to membrane, membrane	molecular_function, protein binding		
YLR239C	LIP2	Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups [Source:SGD;Acc:S000004229]	lipoate biosynthetic process, protein lipoylation, protein modification process	cytoplasm, mitochondrion	acyltransferase activity, catalytic activity, ligase activity, lipoyl(octanoyl) transferase activity, octanoyltransferase activity, transferase activity		
YLR240W	VPS34	Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p [Source:SGD;Acc:S000004230]	peroxisome degradation, phosphatidylinositol phosphorylation, phosphatidylinositol-mediated signaling, protein phosphorylation, protein transport, transport	Golgi apparatus, endosome, endosome membrane, fungal-type vacuole membrane, membrane, peroxisome, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex I, phosphatidylinositol 3-kinase complex II, pre-autophagosomal structure	1-phosphatidylinositol-3-kinase activity, ATP binding, binding, inositol or phosphatidylinositol kinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein binding, protein kinase activity, transferase activity		
YLR241W	YLR241W	Putative protein of unknown function, may be involved in detoxification [Source:SGD;Acc:S000004231]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YLR242C	ARV1	Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p [Source:SGD;Acc:S000004232]	intracellular sterol transport, lipid metabolic process, lipid transport, pheromone-dependent signal transduction involved in conjugation with cellular fusion, sphingolipid metabolic process, sterol metabolic process, transport	Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YLR243W	YLR243W	Putative protein of unknown function; YLR243W is an essential gene [Source:SGD;Acc:S000004233]	biological_process	cellular_component	GTP binding, nucleotide binding, signal sequence binding		
YLR244C	MAP1	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p [Source:SGD;Acc:S000004234]	cellular process, protein initiator methionine removal involved in protein maturation, proteolysis	cytosolic ribosome	aminopeptidase activity, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metalloexopeptidase activity, peptidase activity		
YLR245C	CDD1	Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm [Source:SGD;Acc:S000004235]	cytidine catabolic process, cytidine metabolic process, deoxycytidine catabolic process, pyrimidine-containing compound salvage	cytoplasm, nucleus	catalytic activity, cytidine deaminase activity, hydrolase activity, metal ion binding, zinc ion binding		
YLR246W	ERF2	Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole [Source:SGD;Acc:S000004236]	protein palmitoylation, protein targeting to membrane	endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum palmitoyltransferase complex, integral to endoplasmic reticulum membrane, integral to membrane, membrane	acyltransferase activity, metal ion binding, protein-cysteine S-palmitoleyltransferase activity, transferase activity, zinc ion binding		
YLR247C	IRC20	Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000004237]	biological_process, response to stress	mitochondrion, nucleus	ATP binding, DNA binding, helicase activity, hydrolase activity, metal ion binding, molecular_function, nucleic acid binding, nucleotide binding, protein binding, zinc ion binding		
YLR248W	RCK2	Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases [Source:SGD;Acc:S000004238]	cellular response to oxidative stress, osmosensory signaling pathway, protein phosphorylation, regulation of meiosis	cytoplasm	ATP binding, calmodulin binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YLR249W	YEF3	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP [Source:SGD;Acc:S000004239]	translation, translational elongation, translational termination	cytoplasm, cytosolic ribosome, ribosome	ATP binding, ATPase activity, RNA binding, binding, nucleoside-triphosphatase activity, nucleotide binding, rRNA binding, translation elongation factor activity		
YLR250W	SSP120	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000004240]	biological_process	cytoplasm	calcium ion binding, molecular_function		
YLR251W	SYM1	Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 [Source:SGD;Acc:S000004241]	ethanol metabolic process	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YLR252W	YLR252W	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism [Source:SGD;Acc:S000004242]					
YLR253W	YLR253W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene [Source:SGD;Acc:S000004243]	biological_process	mitochondrion	molecular_function		
YLR254C	NDL1	Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends [Source:SGD;Acc:S000004244]	cell cycle, cell division, mitosis, nuclear migration along microtubule, transport	cytoplasm, cytoplasmic microtubule, cytoskeleton, microtubule, nucleus	microtubule plus-end binding		
YLR255C	YLR255C	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004245]					
YLR256W	HAP1	Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus [Source:SGD;Acc:S000004246]	aerobic respiration, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YLR256W-A	YLR256W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007377]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YLR257W	YLR257W	Putative protein of unknown function [Source:SGD;Acc:S000004247]	biological_process	cytoplasm	molecular_function		
YLR258W	GSY2	Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase [Source:SGD;Acc:S000004248]	glycogen biosynthetic process	cytoplasm	catalytic activity, glycogen (starch) synthase activity, transferase activity, transferase activity, transferring glycosyl groups		
YLR259C	HSP60	Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated [Source:SGD;Acc:S000004249]	'de novo' protein folding, cellular protein metabolic process, chaperone-mediated protein complex assembly, protein folding, protein import into mitochondrial intermembrane space, protein maturation, protein refolding, protein stabilization, response to stress	cytoplasm, mitochondrial matrix, mitochondrial nucleoid, mitochondrion	ATP binding, ATPase activity, DNA replication origin binding, chaperone binding, nucleotide binding, single-stranded DNA binding, unfolded protein binding		
YLR260W	LCB5	Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules [Source:SGD;Acc:S000004250]	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, calcium-mediated signaling, lipid metabolic process, response to heat, sphingolipid metabolic process	Golgi apparatus, Golgi membrane, membrane, membrane fraction, soluble fraction	ATP binding, D-erythro-sphingosine kinase activity, diacylglycerol kinase activity, kinase activity, nucleotide binding, sphinganine kinase activity, transferase activity		
YLR261C	VPS63	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect [Source:SGD;Acc:S000004251]					
YLR262C	YPT6	Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 [Source:SGD;Acc:S000004252]	intracellular protein transport, protein transport, retrograde transport, endosome to Golgi, small GTPase mediated signal transduction, transport	Golgi apparatus, membrane, plasma membrane	GTP binding, GTPase activity, nucleotide binding		
YLR262C-A	TMA7	Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin [Source:SGD;Acc:S000007246]	translation	cytoplasm, nucleus	molecular_function		
YLR263W	RED1	Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p [Source:SGD;Acc:S000004253]	chromosome segregation, meiosis, meiotic recombination checkpoint, positive regulation of catalytic activity, reciprocal meiotic recombination, sporulation resulting in formation of a cellular spore, synaptonemal complex assembly	lateral element, nucleus	chromatin DNA binding, structural molecule activity		
YLR264C-A	YLR264C-A	Putative protein of unknown function [Source:SGD;Acc:S000028808]	biological_process	cellular_component	molecular_function		
YLR264W	RPS28B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein [Source:SGD;Acc:S000004254]	rRNA export from nucleus, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YLR265C	NEJ1	Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p [Source:SGD;Acc:S000004255]	DNA repair, double-strand break repair, response to DNA damage stimulus	DNA ligase IV complex, cytoplasm, integral to membrane, membrane, nuclear membrane, nucleus	DNA binding		
YLR266C	PDR8	Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon [Source:SGD;Acc:S000004256]	positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to stress	cytoplasm, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YLR267W	BOP2	Protein of unknown function [Source:SGD;Acc:S000004257]	biological_process	cellular_component	molecular_function		
YLR268W	SEC22	R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog [Source:SGD;Acc:S000004258]	ER to Golgi vesicle-mediated transport, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle fusion with Golgi apparatus, vesicle fusion with endoplasmic reticulum, vesicle-mediated transport	ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, SNARE complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	SNAP receptor activity		
YLR269C	YLR269C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004259]					
YLR270W	DCS1	Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p [Source:SGD;Acc:S000004260]	deadenylation-dependent decapping of nuclear-transcribed mRNA, nuclear-transcribed mRNA catabolic process, deadenylation-independent decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm, cytoplasmic mRNA processing body, mitochondrion, nucleus	catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, m7G(5')pppN diphosphatase activity		
YLR271W	YLR271W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000004261]	biological_process	cytoplasm, intracellular, nucleus	molecular_function, nucleic acid binding		
YLR272C	YCS4	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus [Source:SGD;Acc:S000004262]	cell cycle, cell division, chromatin silencing at silent mating-type cassette, chromosome condensation, maintenance of rDNA, meiotic chromosome condensation, mitosis, mitotic chromosome condensation, mitotic sister chromatid segregation, tRNA gene clustering	chromosome, nuclear condensin complex, nucleolus, nucleus	binding, molecular_function		
YLR273C	PIG1	Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase [Source:SGD;Acc:S000004263]	glycogen biosynthetic process, regulation of glycogen biosynthetic process	protein phosphatase type 1 complex	protein binding, protein phosphatase type 1 regulator activity		
YLR274W	MCM5	Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase [Source:SGD;Acc:S000004264]	DNA replication, DNA-dependent DNA replication initiation, S phase of mitotic cell cycle, cell cycle, chromatin silencing at telomere, double-strand break repair via break-induced replication, establishment of chromatin silencing, negative regulation of chromatin silencing at telomere, pre-replicative complex assembly, regulation of DNA-dependent DNA replication initiation	DNA replication preinitiation complex, MCM complex, cytoplasm, nuclear chromosome, telomeric region, nucleus, pre-replicative complex, replication fork protection complex	ATP binding, DNA binding, DNA replication origin binding, chromatin binding, nucleoside-triphosphatase activity, nucleotide binding, single-stranded DNA binding		
YLR275W	SMD2	Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 [Source:SGD;Acc:S000004265]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, nucleus, ribonucleoprotein complex	RNA binding, molecular_function		
YLR276C	DBP9	ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit [Source:SGD;Acc:S000004266]	rRNA processing, ribosomal large subunit assembly, ribosome biogenesis	nucleolus, nucleus	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YLR277C	YSH1	Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs [Source:SGD;Acc:S000004267]	RNA splicing, mRNA cleavage, mRNA polyadenylation, mRNA processing, snoRNA 3'-end processing, snoRNA splicing, termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex, mRNA cleavage factor complex, nucleus	RNA binding, endonuclease activity, endoribonuclease activity, hydrolase activity, metal ion binding, nuclease activity		
YLR278C	YLR278C	Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene [Source:SGD;Acc:S000004268]	biological_process, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YLR279W	YLR279W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004269]					
YLR280C	YLR280C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004270]					
YLR281C	YLR281C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene [Source:SGD;Acc:S000004271]	biological_process, translational termination	mitochondrion	molecular_function, translation release factor activity		
YLR282C	YLR282C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition [Source:SGD;Acc:S000004272]					
YLR283W	YLR283W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene [Source:SGD;Acc:S000004273]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YLR284C	ECI1	Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced [Source:SGD;Acc:S000004274]	fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process, metabolic process	peroxisome	catalytic activity, dodecenoyl-CoA delta-isomerase activity, isomerase activity		
YLR285C-A	YLR285C-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028569]	biological_process	cellular_component	molecular_function		
YLR285W	NNT1	Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination [Source:SGD;Acc:S000004275]	chromatin silencing at rDNA, nicotinamide metabolic process	cytoplasm	methyltransferase activity, nicotinamide N-methyltransferase activity, transferase activity		
YLR286C	CTS1	Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p [Source:SGD;Acc:S000004276]	carbohydrate metabolic process, cellular cell wall organization, chitin catabolic process, cytokinesis, completion of separation, metabolic process, polysaccharide catabolic process	cell wall, cellular bud neck, endoplasmic reticulum, extracellular region, fungal-type cell wall, nuclear envelope	catalytic activity, cation binding, chitin binding, chitinase activity, endochitinase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds		
YLR286W-A	YLR286W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CTS1 [Source:SGD;Acc:S000028679]					
YLR287C	YLR287C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene [Source:SGD;Acc:S000004277]	biological_process	cytoplasm	molecular_function		
YLR287C-A	RPS30A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein [Source:SGD;Acc:S000004278]	translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome, stress granule	structural constituent of ribosome		
YLR288C	MEC3	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 [Source:SGD;Acc:S000004279]	DNA damage checkpoint, DNA metabolic process, DNA repair, cell cycle, chromatin silencing at telomere, response to DNA damage stimulus, telomere maintenance via recombination	checkpoint clamp complex, nucleus	DNA binding		
YLR289W	GUF1	Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor [Source:SGD;Acc:S000004280]	positive regulation of translation, translation	membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrion	GTP binding, GTPase activity, hydrolase activity, nucleotide binding, ribosome binding		
YLR290C	YLR290C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene [Source:SGD;Acc:S000004281]	biological_process, metabolic process	mitochondrion	binding, catalytic activity, molecular_function, oxidoreductase activity		
YLR291C	GCD7	Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000004282]	cellular metabolic process, regulation of translation, regulation of translational initiation, translation	eukaryotic translation initiation factor 2B complex, guanyl-nucleotide exchange factor complex, mitochondrion	enzyme regulator activity, guanyl-nucleotide exchange factor activity, translation initiation factor activity		
YLR292C	SEC72	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER [Source:SGD;Acc:S000004283]	posttranslational protein targeting to membrane, translocation, protein transport, transport	Sec62/Sec63 complex, cytoplasm, endoplasmic reticulum membrane	binding, protein transporter activity		
YLR293C	GSP1	Ran GTPase, GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog [Source:SGD;Acc:S000004284]	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), intracellular protein transport, nucleocytoplasmic transport, nucleus organization, protein transport, regulation of chromatin silencing at telomere, signal transduction, transport	cytoplasm, nucleus	GTP binding, GTPase activity, nucleotide binding		
YLR294C	YLR294C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14 [Source:SGD;Acc:S000004285]					
YLR295C	ATP14	Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis [Source:SGD;Acc:S000004286]	ATP biosynthetic process, ATP synthesis coupled proton transport, cristae formation, ion transport, mitochondrial proton-transporting ATP synthase complex assembly, proton transport, transport	membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrion, proton-transporting ATP synthase complex, coupling factor F(o)	ATPase activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism		
YLR296W	YLR296W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004287]					
YLR297W	YLR297W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000004288]	biological_process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YLR298C	YHC1	Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site [Source:SGD;Acc:S000004289]	nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, commitment complex, nucleus, ribonucleoprotein complex	RNA binding, mRNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YLR299C-A	YLR299C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ECM38 [Source:SGD;Acc:S000028680]					
YLR299W	ECM38	Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation [Source:SGD;Acc:S000004290]	glutathione biosynthetic process, glutathione catabolic process, xenobiotic metabolic process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	acyltransferase activity, gamma-glutamyltransferase activity, transferase activity		
YLR300W	EXG1	Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes [Source:SGD;Acc:S000004291]	carbohydrate metabolic process, cellular cell wall organization, cellular glucan metabolic process, fungal-type cell wall organization, metabolic process	cell wall, extracellular region, fungal-type cell wall	catalytic activity, cation binding, glucan exo-1,3-beta-glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds		
YLR301W	YLR301W	Protein of unknown function that interacts with Sec72p [Source:SGD;Acc:S000004292]	cotranslational protein targeting to membrane	cytoplasm, endoplasmic reticulum membrane, nucleus	molecular_function		
YLR302C	YLR302C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004293]					
YLR303W	MET17	Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis [Source:SGD;Acc:S000004294]	cellular amino acid biosynthetic process, cellular amino acid metabolic process, cysteine biosynthetic process, methionine biosynthetic process, methionine metabolic process	cytoplasm, plasma membrane enriched fraction	O-acetylhomoserine aminocarboxypropyltransferase activity, catalytic activity, cysteine synthase activity, pyridoxal phosphate binding, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups		
YLR304C	ACO1	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy [Source:SGD;Acc:S000004295]	citrate metabolic process, glutamate biosynthetic process, metabolic process, mitochondrial genome maintenance, propionate metabolic process, tricarboxylic acid cycle	cytoplasm, cytosol, mitochondrial matrix, mitochondrial nucleoid, mitochondrion	4 iron, 4 sulfur cluster binding, aconitate hydratase activity, double-stranded DNA binding, iron-sulfur cluster binding, lyase activity, metal ion binding, single-stranded DNA binding		
YLR305C	STT4	Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization [Source:SGD;Acc:S000004296]	phosphatidylinositol phosphorylation, phosphatidylinositol-mediated signaling	mitochondrion, plasma membrane	1-phosphatidylinositol 4-kinase activity, ATP binding, binding, inositol or phosphatidylinositol kinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YLR306W	UBC12	Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes [Source:SGD;Acc:S000004297]	post-translational protein modification, protein modification process, protein neddylation, regulation of protein metabolic process	cellular_component	ATP binding, NEDD8 ligase activity, acid-amino acid ligase activity, ligase activity, nucleotide binding, small conjugating protein ligase activity		
YLR307C-A	YLR307C-A	Putative protein of unknown function [Source:SGD;Acc:S000028525]	biological_process	cellular_component	molecular_function		
YLR307W	CDA1	Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall [Source:SGD;Acc:S000004298]	ascospore wall assembly, carbohydrate metabolic process, chitin catabolic process, polysaccharide catabolic process, sporulation resulting in formation of a cellular spore	chitosan layer of spore wall	catalytic activity, chitin deacetylase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds		
YLR308W	CDA2	Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall [Source:SGD;Acc:S000004299]	ascospore wall assembly, carbohydrate metabolic process, chitin catabolic process, polysaccharide catabolic process, sporulation resulting in formation of a cellular spore	chitosan layer of spore wall	catalytic activity, chitin deacetylase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds		
YLR309C	IMH1	Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi [Source:SGD;Acc:S000004300]	Golgi to plasma membrane protein transport, protein transport, response to stress, transport, vesicle-mediated transport	Golgi apparatus, Golgi membrane, cytoplasm, cytosol, membrane	molecular_function, protein binding		
YLR310C	CDC25	Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 [Source:SGD;Acc:S000004301]	Ras protein signal transduction, cell cycle, cell division, mitosis, regulation of cell cycle, regulation of small GTPase mediated signal transduction, replicative cell aging, small GTPase mediated signal transduction, traversing start control point of mitotic cell cycle	cytoplasm, cytosol, integral to membrane, intracellular, membrane, nucleus, plasma membrane	Ras guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity, protein binding		
YLR311C	YLR311C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004302]					
YLR312C	YLR312C	Putative protein of unknown function [Source:SGD;Acc:S000004303]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YLR312W-A	MRPL15	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004304]	RNA processing, mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, ribonuclease III activity, structural constituent of ribosome		
YLR313C	SPH1	Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p [Source:SGD;Acc:S000004305]	Rho protein signal transduction, actin filament organization, bipolar cellular bud site selection, conjugation, establishment of cell polarity, pseudohyphal growth, regulation of cell shape	cellular bud neck, cellular bud tip, cytoplasm, cytoskeleton, incipient cellular bud site, mating projection, polarisome	actin binding, cytoskeletal regulatory protein binding		
YLR314C	CDC3	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM [Source:SGD;Acc:S000004306]	axial cellular bud site selection, cell cycle, cell division, cell morphogenesis, cytokinesis, establishment of cell polarity, fungal-type cell wall organization	ascospore wall, cellular bud neck, cellular bud neck septin ring, mating projection base, membrane, prospore membrane, septin complex	1-phosphatidylinositol binding, GTP binding, nucleotide binding, structural constituent of cytoskeleton		
YLR315W	NKP2	Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) [Source:SGD;Acc:S000004307]	biological_process, cell cycle, cell division, meiosis, mitosis	chromosome, centromeric region, condensed chromosome kinetochore, kinetochore, nucleus, spindle pole body	molecular_function		
YLR316C	TAD3	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs [Source:SGD;Acc:S000004308]	tRNA modification, tRNA processing	cytoplasm, nucleus	catalytic activity, hydrolase activity, tRNA-specific adenosine deaminase activity, zinc ion binding		
YLR317W	YLR317W	Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C [Source:SGD;Acc:S000004309]					
YLR318W	EST2	Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia [Source:SGD;Acc:S000004310]	RNA-dependent DNA replication, replicative cell aging, telomere maintenance via telomerase	chromosome, telomeric region, nucleolus, nucleus, telomerase catalytic core complex, telomerase holoenzyme complex	DNA binding, RNA binding, RNA-directed DNA polymerase activity, nucleotidyltransferase activity, telomerase activity, telomeric DNA binding, telomeric template RNA reverse transcriptase activity, transferase activity		
YLR319C	BUD6	Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate [Source:SGD;Acc:S000004311]	Rho protein signal transduction, bipolar cellular bud site selection, cellular bud site selection, cytokinesis, establishment of cell polarity, extrachromosomal circular DNA localization involved in cell aging, positive regulation of formin-nucleated actin cable assembly, response to osmotic stress	actin cap, mating projection tip, polarisome, spindle pole body	cytoskeletal regulatory protein binding		
YLR320W	MMS22	Protein that acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; required for accurate meiotic chromosome segregation [Source:SGD;Acc:S000004312]	DNA repair, double-strand break repair, meiotic sister chromatid segregation, recombinational repair, replication fork processing, response to DNA damage stimulus	Cul8-RING ubiquitin ligase complex, nucleus	molecular_function		
YLR321C	SFH1	Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog [Source:SGD;Acc:S000004313]	ATP-dependent chromatin remodeling, G2/M transition of mitotic cell cycle, cell cycle, chromatin modification, chromatin remodeling, chromatin remodeling at centromere, chromosome segregation, double-strand break repair, nucleosome disassembly, regulation of DNA replication involved in S phase, transcription elongation from RNA polymerase II promoter	RSC complex, chromatin remodeling complex, nuclear chromosome, nucleus	DNA-dependent ATPase activity		
YLR322W	VPS65	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth [Source:SGD;Acc:S000004314]					
YLR323C	CWC24	Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p [Source:SGD;Acc:S000004315]	RNA splicing, mRNA processing, snoRNA splicing	U2-type spliceosomal complex, nucleus, spliceosomal complex	DNA binding, metal ion binding, molecular_function, nucleic acid binding, protein binding, zinc ion binding		
YLR324W	PEX30	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p [Source:SGD;Acc:S000004316]	peroxisome organization	integral to membrane, integral to peroxisomal membrane, membrane, peroxisomal membrane, peroxisome	molecular_function		
YLR325C	RPL38	Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein [Source:SGD;Acc:S000004317]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YLR326W	YLR326W	Putative protein of unknown function, predicted to be palmitoylated [Source:SGD;Acc:S000004318]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YLR327C	TMA10	Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p [Source:SGD;Acc:S000004319]	biological_process	cytoplasm, mitochondrion, nucleus, ribosome	molecular_function		
YLR328W	NMA1	Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways [Source:SGD;Acc:S000004320]	NAD biosynthetic process, NAD metabolic process, biosynthetic process, pyridine nucleotide biosynthetic process	cytoplasm, nucleus	ATP binding, nicotinamide-nucleotide adenylyltransferase activity, nucleotide binding, nucleotidyltransferase activity, transferase activity		
YLR329W	REC102	Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination [Source:SGD;Acc:S000004321]	meiosis, meiotic DNA double-strand break formation, reciprocal meiotic recombination	condensed nuclear chromosome, nucleus	molecular_function		
YLR330W	CHS5	Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane [Source:SGD;Acc:S000004322]	Golgi to plasma membrane transport, ascospore wall assembly, cell wall chitin catabolic process, cellular bud site selection, conjugation with cellular fusion, protein transport, transport	Golgi apparatus, cytoplasm, exomer complex, intracellular, mating projection tip, membrane, trans-Golgi network membrane	molecular_function, protein binding		
YLR331C	JIP3	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 [Source:SGD;Acc:S000004323]					
YLR332W	MID2	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p [Source:SGD;Acc:S000004324]	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response, cell morphogenesis involved in conjugation, fungal-type cell wall organization, peroxisome degradation, response to acid, response to osmotic stress, response to stress	integral to membrane, integral to plasma membrane, mating projection tip, membrane, plasma membrane	transmembrane receptor activity		
YLR333C	RPS25B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein [Source:SGD;Acc:S000004325]	translation	cytoplasm, cytosolic small ribosomal subunit, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YLR334C	YLR334C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here [Source:SGD;Acc:S000004326]					
YLR335W	NUP2	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization [Source:SGD;Acc:S000004327]	NLS-bearing substrate import into nucleus, chromatin silencing at telomere, intracellular transport, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, nuclear-transcribed mRNA catabolic process, non-stop decay, protein export from nucleus, protein targeting to membrane, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	membrane, mitochondrion, nuclear chromatin, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YLR336C	SGD1	Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia [Source:SGD;Acc:S000004328]	RNA metabolic process, hyperosmotic response, ribosomal small subunit biogenesis	nucleolus, nucleus	binding, molecular_function, protein binding		
YLR337C	VRP1	Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) [Source:SGD;Acc:S000004329]	actin cortical patch localization, actin cytoskeleton organization, actin filament organization, bipolar cellular bud site selection, endocytosis	actin cortical patch, cellular bud neck, cytoplasm, cytoskeleton, incipient cellular bud site, mating projection tip	actin binding, protein binding		
YLR338W	OPI9	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C [Source:SGD;Acc:S000004330]					
YLR339C	YLR339C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0 [Source:SGD;Acc:S000004331]					
YLR340W	RPP0	Conserved ribosomal protein P0 of the ribosomal stalk, which is involved in interaction between translational elongation factors and the ribosome; similar to rat P0, human P0, and E. coli L10e; phosphorylated on serine 302 [Source:SGD;Acc:S000004332]	ribosomal large subunit assembly, ribosome biogenesis, translation, translational elongation	90S preribosome, cytoplasm, cytosolic large ribosomal subunit, intracellular, preribosome, large subunit precursor, ribonucleoprotein complex, ribosome	LSU rRNA binding, structural constituent of ribosome		
YLR341W	SPO77	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis [Source:SGD;Acc:S000004333]	ascospore formation, ascospore wall assembly, sporulation resulting in formation of a cellular spore	cytoplasm, intracellular	molecular_function		
YLR342W	FKS1	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling [Source:SGD;Acc:S000004334]	1,3-beta-D-glucan biosynthetic process, cellular cell wall organization, positive regulation of endocytosis, regulation of cell shape, regulation of cell size	1,3-beta-D-glucan synthase complex, actin cap, actin cortical patch, integral to membrane, membrane, membrane fraction, mitochondrion, plasma membrane	1,3-beta-D-glucan synthase activity, transferase activity, transferase activity, transferring glycosyl groups		
YLR342W-A	YLR342W-A	Putative protein of unknown function [Source:SGD;Acc:S000028571]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YLR343W	GAS2	1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p [Source:SGD;Acc:S000004335]	ascospore wall assembly, carbohydrate metabolic process, cellular cell wall organization	anchored to membrane, cytoplasm, membrane, plasma membrane	1,3-beta-glucanosyltransferase activity, catalytic activity, cation binding, transferase activity		
YLR344W	RPL26A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA [Source:SGD;Acc:S000004336]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, large ribosomal subunit, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YLR345W	YLR345W	Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene [Source:SGD;Acc:S000004337]	fructose 2,6-bisphosphate metabolic process, fructose metabolic process, regulation of glycolysis	cytoplasm	6-phosphofructo-2-kinase activity, ATP binding, catalytic activity, fructose-2,6-bisphosphate 2-phosphatase activity, hydrolase activity, kinase activity, nucleotide binding, transferase activity		
YLR346C	YLR346C	Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene [Source:SGD;Acc:S000004338]	biological_process	mitochondrion	molecular_function		
YLR347C	KAP95	Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p [Source:SGD;Acc:S000004339]	intracellular protein transport, nuclear pore complex assembly, phosphatidylcholine biosynthetic process, protein import into nucleus, protein targeting to membrane, protein transport, transport	cytoplasm, nuclear envelope, nuclear exosome (RNase complex), nuclear pore, nucleus	Ran guanyl-nucleotide exchange factor activity, binding, protein transporter activity		
YLR347W-A	YLR347W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF KAP95/YLR347C [Source:SGD;Acc:S000028681]					
YLR348C	DIC1	Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix [Source:SGD;Acc:S000004340]	dicarboxylic acid transport, phosphate transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion	antiporter activity, binding, dicarboxylic acid transmembrane transporter activity		
YLR349W	YLR349W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C [Source:SGD;Acc:S000004341]					
YLR350W	ORM2	Evolutionarily conserved protein, similar to Orm1p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control [Source:SGD;Acc:S000004342]	negative regulation of sphingolipid biosynthetic process, response to unfolded protein	SPOTS complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YLR351C	NIT3	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member [Source:SGD;Acc:S000004343]	biological_process, nitrogen compound metabolic process	cytoplasm, mitochondrion	hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds		
YLR352W	YLR352W	Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene [Source:SGD;Acc:S000004344]	biological_process	cellular_component	molecular_function		
YLR353W	BUD8	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole [Source:SGD;Acc:S000004345]	cell cycle, cellular bud site selection, pseudohyphal growth	cellular bud tip, incipient cellular bud site, integral to membrane, membrane, plasma membrane	molecular_function		
YLR354C	TAL1	Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate [Source:SGD;Acc:S000004346]	carbohydrate metabolic process, metabolic process, pentose-phosphate shunt	cytoplasm	catalytic activity, sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity, transferase activity		
YLR355C	ILV5	Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids [Source:SGD;Acc:S000004347]	branched chain family amino acid biosynthetic process, cellular amino acid biosynthetic process, metabolic process, mitochondrial genome maintenance, oxidation-reduction process	mitochondrial nucleoid, mitochondrion	binding, catalytic activity, coenzyme binding, ketol-acid reductoisomerase activity, metal ion binding, oxidoreductase activity		
YLR356W	ATG33	Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes [Source:SGD;Acc:S000004348]	autophagy, mitochondrion degradation	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YLR357W	RSC2	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance [Source:SGD;Acc:S000004349]	ATP-dependent chromatin remodeling, chromatin modification, double-strand break repair via nonhomologous end joining, nucleosome disassembly, plasmid maintenance, sister chromatid cohesion, sporulation resulting in formation of a cellular spore, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	DNA binding, DNA-dependent ATPase activity, protein binding		
YLR358C	YLR358C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSC2/YLR357W [Source:SGD;Acc:S000004350]					
YLR359W	ADE13	Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency [Source:SGD;Acc:S000004351]	'de novo' IMP biosynthetic process, purine nucleotide biosynthetic process, purine ribonucleotide biosynthetic process	cellular_component	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity, N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity, catalytic activity, lyase activity		
YLR360W	VPS38	Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity [Source:SGD;Acc:S000004352]	ER-associated protein catabolic process, late endosome to vacuole transport, protein transport, transport	Golgi apparatus, endosome, endosome membrane, membrane, phosphatidylinositol 3-kinase complex II	molecular_function		
YLR361C	DCR2	Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START [Source:SGD;Acc:S000004353]	cell cycle, endoplasmic reticulum unfolded protein response, protein dephosphorylation, traversing start control point of mitotic cell cycle	cellular_component, cytoplasm	ATP binding, hydrolase activity, hydrolase activity, acting on ester bonds, nucleotide binding, phosphoprotein phosphatase activity, phosphoric ester hydrolase activity		
YLR361C-A	YLR361C-A	Putative protein of unknown function [Source:SGD;Acc:S000028845]	biological_process	cellular_component	molecular_function		
YLR362W	STE11	Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p [Source:SGD;Acc:S000004354]	MAPKKK cascade involved in cell wall biogenesis, MAPKKK cascade involved in osmosensory signaling pathway, activation of MAPKK activity, invasive growth in response to glucose limitation, osmosensory signaling pathway via Sho1 osmosensor, pheromone-dependent signal transduction involved in conjugation with cellular fusion, protein phosphorylation, pseudohyphal growth, regulation of transposition, RNA-mediated, response to pheromone, signal transduction involved in filamentous growth	cytoplasm	ATP binding, MAP kinase kinase kinase activity, SAM domain binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YLR363C	NMD4	Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway [Source:SGD;Acc:S000004355]	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm	molecular_function		
YLR363W-A	YLR363W-A	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus [Source:SGD;Acc:S000007620]	biological_process	nucleus	molecular_function		
YLR364C-A	YLR364C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR366W [Source:SGD;Acc:S000028846]					
YLR364W	GRX8	Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic [Source:SGD;Acc:S000004356]	biological_process, cell redox homeostasis, electron transport chain, transport	cytoplasm	electron carrier activity, glutathione-disulfide reductase activity, protein disulfide oxidoreductase activity		
YLR365W	YLR365W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene [Source:SGD;Acc:S000004357]					
YLR366W	YLR366W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A [Source:SGD;Acc:S000004358]					
YLR367W	RPS22B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins [Source:SGD;Acc:S000004359]	translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YLR368W	MDM30	F-box protein; associates with mitochondria and has a role in mitochondrial fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains [Source:SGD;Acc:S000004360]	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, chronological cell aging, mitochondrial fusion, mitochondrion organization, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, proteolysis involved in cellular protein catabolic process, regulation of mRNA export from nucleus	SCF ubiquitin ligase complex, cytoplasm, mitochondrion	protein binding, ubiquitin-protein ligase activity		
YLR369W	SSQ1	Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia [Source:SGD;Acc:S000004361]	intracellular sequestering of iron ion, iron-sulfur cluster assembly, protein maturation, response to stress	mitochondrial matrix, mitochondrion	ATP binding, nucleotide binding, unfolded protein binding		
YLR370C	ARC18	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches [Source:SGD;Acc:S000004362]	actin filament organization, establishment of mitochondrion localization, mitochondrion inheritance, regulation of actin filament polymerization	Arp2/3 protein complex, cytoplasm, cytoskeleton, mitochondrion	actin binding, molecular_function		
YLR371W	ROM2	GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP [Source:SGD;Acc:S000004363]	actin filament organization, budding cell bud growth, establishment of cell polarity, fungal-type cell wall organization, intracellular signal transduction, positive regulation of endocytosis, regulation of Rho protein signal transduction, response to stress, small GTPase mediated signal transduction	cellular bud tip, intracellular	Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity, phosphatidylinositol-4,5-bisphosphate binding, small GTPase regulator activity		
YLR372W	SUR4	Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis [Source:SGD;Acc:S000004364]	fatty acid biosynthetic process, fatty acid elongation, lipid biosynthetic process, post-Golgi vesicle-mediated transport, sphingolipid biosynthetic process	endoplasmic reticulum, integral to membrane, membrane	fatty acid elongase activity		
YLR373C	VID22	Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles [Source:SGD;Acc:S000004365]	protein transport, transport, vacuolar protein catabolic process	integral to membrane, integral to plasma membrane, membrane, nucleus, plasma membrane	DNA binding, metal ion binding, molecular_function, nucleic acid binding		
YLR374C	YLR374C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W [Source:SGD;Acc:S000004366]					
YLR375W	STP3	Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids [Source:SGD;Acc:S000004367]	biological_process	intracellular, nucleus	metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YLR376C	PSY3	Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair; deletion results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C [Source:SGD;Acc:S000004368]	DNA repair, recombinational repair, response to DNA damage stimulus	cytoplasm, nucleus	molecular_function		
YLR377C	FBP1	Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p [Source:SGD;Acc:S000004369]	carbohydrate metabolic process, gluconeogenesis	cytosol	catalytic activity, fructose 1,6-bisphosphate 1-phosphatase activity, hydrolase activity, metal ion binding, phosphoric ester hydrolase activity		
YLR378C	SEC61	Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER [Source:SGD;Acc:S000004370]	SRP-dependent cotranslational protein targeting to membrane, translocation, peptide transport, posttranslational protein targeting to membrane, translocation, protein transport, retrograde protein transport, ER to cytosol, transmembrane transport, transport	Sec61 translocon complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity, peptide transporter activity, signal sequence binding		
YLR379W	YLR379W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C [Source:SGD;Acc:S000004371]					
YLR380W	CSR1	Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance [Source:SGD;Acc:S000004372]	ER-associated protein catabolic process, fungal-type cell wall organization, lipid metabolic process, lipid transport, phospholipid catabolic process, phospholipid transport, regulation of fatty acid metabolic process, transport	cytoplasm, cytosol, endosome, lipid particle, microsome, mitochondrion	phosphatidylinositol transporter activity		
YLR381W	CTF3	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules [Source:SGD;Acc:S000004373]	cell cycle, cell division, chromosome segregation, establishment of mitotic sister chromatid cohesion, meiosis, mitosis	chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, kinetochore, nucleus			
YLR382C	NAM2	Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance [Source:SGD;Acc:S000004374]	Group I intron splicing, leucyl-tRNA aminoacylation, mitochondrial translation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, leucine-tRNA ligase activity, ligase activity, mRNA binding, nucleotide binding		
YLR383W	SMC6	Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18 [Source:SGD;Acc:S000004375]	DNA recombination, DNA repair, response to DNA damage stimulus	Smc5-Smc6 complex, chromosome, mitochondrion, nucleus	ATP binding, molecular_function, nucleotide binding		
YLR384C	IKI3	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) [Source:SGD;Acc:S000004376]	protein transport, regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification, transport	Elongator holoenzyme complex, cytoplasm, nucleus	molecular_function		
YLR385C	SWC7	Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin [Source:SGD;Acc:S000004377]	chromatin modification, chromatin remodeling	Swr1 complex, nucleus	molecular_function		
YLR386W	VAC14	Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p [Source:SGD;Acc:S000004378]	phosphatidylinositol biosynthetic process, positive regulation of kinase activity, protein transport, transport	PAS complex, extrinsic to vacuolar membrane, fungal-type vacuole membrane, membrane, vacuolar membrane, vacuole	binding, protein binding, bridging		
YLR387C	REH1	Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains [Source:SGD;Acc:S000004379]	ribosomal large subunit biogenesis	cytoplasm, cytosolic large ribosomal subunit, intracellular, preribosome, large subunit precursor	metal ion binding, molecular_function, zinc ion binding		
YLR388W	RPS29A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins [Source:SGD;Acc:S000004380]	translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	metal ion binding, structural constituent of ribosome		
YLR389C	STE23	Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family [Source:SGD;Acc:S000004381]	peptide pheromone maturation, proteolysis, response to pheromone	peripheral to membrane of membrane fraction	catalytic activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding		
YLR390W	ECM19	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004382]	cellular cell wall organization, fungal-type cell wall organization	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YLR390W-A	CCW14	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall [Source:SGD;Acc:S000006429]	fungal-type cell wall organization	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane, mitochondrion	structural constituent of cell wall		
YLR392C	ART10	Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene [Source:SGD;Acc:S000004384]	biological_process, endocytosis	cytoplasm	molecular_function		
YLR393W	ATP10	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 [Source:SGD;Acc:S000004385]	mitochondrial proton-transporting ATP synthase complex assembly	integral to mitochondrial membrane, membrane, mitochondrial inner membrane, mitochondrion	unfolded protein binding		
YLR394W	CST9	SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate [Source:SGD;Acc:S000004386]	DNA repair, meiosis, protein sumoylation, reciprocal meiotic recombination, response to DNA damage stimulus, synapsis, synaptonemal complex assembly	chromosome, condensed nuclear chromosome, nuclear chromosome, nucleus	SUMO ligase activity, zinc ion binding		
YLR395C	COX8	Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain [Source:SGD;Acc:S000004387]	mitochondrial electron transport, cytochrome c to oxygen, oxidation-reduction process	membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion	cytochrome-c oxidase activity, oxidoreductase activity		
YLR396C	VPS33	ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole [Source:SGD;Acc:S000004388]	Golgi to vacuole transport, endocytosis, piecemeal microautophagy of nucleus, protein targeting to vacuole, protein transport, regulation of SNARE complex assembly, regulation of vacuole fusion, non-autophagic, transport, vacuole fusion, non-autophagic, vacuole organization, vesicle docking, vesicle docking involved in exocytosis, vesicle fusion with vacuole, vesicle-mediated transport	CORVET complex, HOPS complex, cytosol, fungal-type vacuole, fungal-type vacuole membrane, vacuole	ATP binding, phosphatidylinositol binding		
YLR397C	AFG2	ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs [Source:SGD;Acc:S000004389]	response to drug, ribosomal large subunit biogenesis	intracellular, preribosome, large subunit precursor	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding		
YLR398C	SKI2	Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay [Source:SGD;Acc:S000004390]	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, regulation of translation, response to virus	Ski complex, cytoplasm	ATP binding, ATP-dependent helicase activity, DNA binding, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, nucleic acid binding, nucleotide binding		
YLR399C	BDF1	Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p [Source:SGD;Acc:S000004391]	DNA repair, ascospore formation, chromatin remodeling, meiosis, response to DNA damage stimulus, sporulation resulting in formation of a cellular spore	nuclear chromatin, nucleus	histone acetyl-lysine binding, protein binding		
YLR399W-A	YLR399W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the characterized ORF BDF1/YLR399C [Source:SGD;Acc:S000028682]					
YLR400W	YLR400W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004392]					
YLR401C	DUS3	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region [Source:SGD;Acc:S000004393]	metabolic process, oxidation-reduction process, tRNA modification, tRNA processing	cytoplasm, nucleus	catalytic activity, flavin adenine dinucleotide binding, metal ion binding, nucleic acid binding, oxidoreductase activity, tRNA dihydrouridine synthase activity, zinc ion binding		
YLR402W	YLR402W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004394]					
YLR403W	SFP1	Transcription factor that controls expression of ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p [Source:SGD;Acc:S000004395]	regulation of cell size, ribosome biogenesis, transcription from RNA polymerase III promoter	cytoplasm, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YLR404W	FLD1	Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy [Source:SGD;Acc:S000004396]	lipid particle organization	cortical endoplasmic reticulum, endoplasmic reticulum, integral to membrane, membrane	molecular_function		
YLR405W	DUS4	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p [Source:SGD;Acc:S000004397]	metabolic process, oxidation-reduction process, tRNA modification, tRNA processing	cellular_component	catalytic activity, flavin adenine dinucleotide binding, oxidoreductase activity, tRNA dihydrouridine synthase activity		
YLR406C	RPL31B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality [Source:SGD;Acc:S000004398]	regulation of translational fidelity, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YLR406C-A	YLR406C-A	Putative protein of unknown function [Source:SGD;Acc:S000028683]	biological_process	cellular_component	molecular_function		
YLR407W	YLR407W	Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus [Source:SGD;Acc:S000004399]	biological_process	cell cortex, cellular_component, cytoplasm	molecular_function		
YLR408C	BLS1	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene [Source:SGD;Acc:S000004400]	biological_process	endosome	molecular_function		
YLR409C	UTP21	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma [Source:SGD;Acc:S000004401]	rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis	90S preribosome, Pwp2p-containing subcomplex of 90S preribosome, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	molecular_function, protein binding		
YLR410W	VIP1	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 [Source:SGD;Acc:S000004402]	inositol phosphate biosynthetic process	cytoplasm, cytoskeleton	ATP binding, acid phosphatase activity, diphosphoinositol-pentakisphosphate kinase activity, inositol heptakisphosphate kinase activity, inositol hexakisphosphate 1-kinase or 3-kinase activity, inositol hexakisphosphate 4-kinase or 6-kinase activity, kinase activity, nucleotide binding, transferase activity		
YLR410W-A	YLR410W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007379]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YLR410W-B	YLR410W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007380]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YLR411W	CTR3	High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae [Source:SGD;Acc:S000004403]	copper ion import, copper ion transport, ion transport, transport	cytoplasmic vesicle, cytoplasmic vesicle membrane, integral to membrane, integral to plasma membrane, membrane	copper ion transmembrane transporter activity, copper uptake transmembrane transporter activity		
YLR412C-A	YLR412C-A	Putative protein of unknown function [Source:SGD;Acc:S000028572]	biological_process	cellular_component	molecular_function		
YLR412W	BER1	Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene [Source:SGD;Acc:S000004404]	biological_process	cytoplasm, cytoskeleton, microtubule	molecular_function		
YLR413W	YLR413W	Putative protein of unknown function; YLR413W is not an essential gene [Source:SGD;Acc:S000004405]	biological_process	cellular_component, integral to membrane, membrane, plasma membrane	molecular_function		
YLR414C	PUN1	Putative protein of unknown function; localizes to bud and cytoplasm; co-localizes with Sur7p in punctate patches in the plasma membrane; null mutant displays decreased thermotolerance; transcription induced on cell wall damage [Source:SGD;Acc:S000004406]	biological_process	cellular bud, cytoplasm, integral to membrane, membrane, membrane raft, plasma membrane, tight junction	molecular_function, structural molecule activity		
YLR415C	YLR415C	Putative protein of unknown function; YLR415C is not an essential gene [Source:SGD;Acc:S000004407]	biological_process	cellular_component, mitochondrion	molecular_function		
YLR416C	YLR416C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004408]					
YLR417W	VPS36	Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome [Source:SGD;Acc:S000004409]	negative regulation of transcription from RNA polymerase II promoter by glucose, protein retention in Golgi apparatus, protein targeting to vacuole, protein transport, transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ESCRT II complex, cytoplasm, endosome, endosome membrane, intracellular, membrane	metal ion binding, ubiquitin binding, zinc ion binding		
YLR418C	CDC73	Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance [Source:SGD;Acc:S000004410]	DNA recombination, histone methylation, transcription elongation from RNA polymerase I promoter, transcription elongation from RNA polymerase II promoter	Cdc73/Paf1 complex, nucleoplasm, nucleus, transcription elongation factor complex			
YLR419W	YLR419W	Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene [Source:SGD;Acc:S000004411]	biological_process	cytoplasm, mitochondrion	ATP binding, ATP-dependent helicase activity, helicase activity, hydrolase activity, molecular_function, nucleic acid binding, nucleoside-triphosphatase activity, nucleotide binding, protein binding		
YLR420W	URA4	Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate [Source:SGD;Acc:S000004412]	'de novo' pyrimidine base biosynthetic process, pyrimidine base biosynthetic process, pyrimidine nucleotide biosynthetic process	cytoplasm, nucleus	dihydroorotase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, metal ion binding		
YLR421C	RPN13	Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability [Source:SGD;Acc:S000004413]	ubiquitin-dependent protein catabolic process	cytoplasm, nucleus, proteasome complex, proteasome regulatory particle, lid subcomplex, proteasome storage granule	ubiquitin binding		
YLR422W	YLR422W	Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein [Source:SGD;Acc:S000004414]	biological_process	cytoplasm	GTP binding, GTPase binding, guanyl-nucleotide exchange factor activity, molecular_function		
YLR423C	ATG17	Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity [Source:SGD;Acc:S000004415]	activation of protein kinase activity, autophagic vacuole assembly, autophagy, mitochondrion degradation, peroxisome degradation, piecemeal microautophagy of nucleus	Atg1p signaling complex, cytoplasm, pre-autophagosomal structure	protein complex scaffold, protein kinase activator activity		
YLR424W	SPP382	Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation [Source:SGD;Acc:S000004416]	RNA splicing, generation of catalytic spliceosome for first transesterification step, mRNA processing, nuclear mRNA splicing, via spliceosome, spliceosome disassembly	U2-type post-mRNA release spliceosomal complex, cytoplasm, intracellular, mitochondrion, nucleus, spliceosomal complex	ATP-dependent RNA helicase activity, RNA binding, nucleic acid binding		
YLR425W	TUS1	Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate [Source:SGD;Acc:S000004417]	fungal-type cell wall organization, regulation of Rho protein signal transduction, signal transduction	cellular_component, intracellular	Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity, protein binding, small GTPase regulator activity		
YLR426W	YLR426W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin [Source:SGD;Acc:S000004418]	metabolic process, oxidation-reduction process, response to drug	integral to membrane, membrane, mitochondrial membrane, mitochondrion	binding, catalytic activity, molecular_function, oxidoreductase activity		
YLR427W	MAG2	Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 [Source:SGD;Acc:S000004419]	biological_process	cytoplasm	metal ion binding, molecular_function, protein binding, zinc ion binding		
YLR428C	YLR428C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 [Source:SGD;Acc:S000004420]					
YLR429W	CRN1	Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly [Source:SGD;Acc:S000004421]	actin cortical patch localization, actin filament organization, microtubule-based process, negative regulation of Arp2/3 complex-mediated actin nucleation	Arp2/3 protein complex, actin cortical patch	actin binding, actin filament binding, microtubule binding, protein binding, protein binding, bridging		
YLR430W	SEN1	Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis [Source:SGD;Acc:S000004422]	DNA repair, rRNA processing, snRNA processing, snoRNA processing, tRNA processing, termination of RNA polymerase II transcription	Nrd1 complex, nucleus	ATP binding, ATP-dependent 5'-3' DNA helicase activity, ATP-dependent 5'-3' RNA helicase activity, ATP-dependent DNA helicase activity, DNA binding, DNA-dependent ATPase activity, RNA-dependent ATPase activity, helicase activity, hydrolase activity, nuclease activity, nucleotide binding		
YLR431C	ATG23	Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p [Source:SGD;Acc:S000004423]	CVT pathway, autophagy, positive regulation of macroautophagy, protein localization to pre-autophagosomal structure, protein transport, transport	cytoplasm, membrane, peripheral to membrane of membrane fraction, pre-autophagosomal structure, pre-autophagosomal structure membrane	molecular_function		
YLR432W	IMD3	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed [Source:SGD;Acc:S000004424]	GMP biosynthetic process, GTP biosynthetic process, metabolic process, oxidation-reduction process, purine nucleotide biosynthetic process	cytoplasm, plasma membrane enriched fraction	IMP dehydrogenase activity, catalytic activity, metal ion binding, oxidoreductase activity, protein binding		
YLR433C	CNA1	Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 [Source:SGD;Acc:S000004425]	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, cellular ion homeostasis, fungal-type cell wall organization	calcineurin complex, cytoplasm	calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity		
YLR434C	YLR434C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W [Source:SGD;Acc:S000004426]					
YLR435W	TSR2	Protein with a potential role in pre-rRNA processing [Source:SGD;Acc:S000004427]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing	cytoplasm, nucleus	molecular_function		
YLR436C	ECM30	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000004428]	cellular cell wall organization, fungal-type cell wall organization	cytoplasm	molecular_function		
YLR437C	DIF1	Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein [Source:SGD;Acc:S000004429]	biological_process	cytoplasm, nucleus	molecular_function		
YLR437C-A	YLR437C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W [Source:SGD;Acc:S000028684]					
YLR438C-A	LSM3	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000006434]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, rRNA processing, tRNA processing	U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, nucleolus, nucleus, ribonucleoprotein complex, small nucleolar ribonucleoprotein complex	RNA binding		
YLR438W	CAR2	L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive [Source:SGD;Acc:S000004430]	arginine catabolic process, ornithine metabolic process	cytoplasm, cytosol, nucleus	catalytic activity, ornithine-oxo-acid transaminase activity, pyridoxal phosphate binding, transaminase activity, transferase activity		
YLR439W	MRPL4	Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit [Source:SGD;Acc:S000004431]	mitochondrial translation, translation	mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YLR440C	SEC39	Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope [Source:SGD;Acc:S000004432]	ER-dependent peroxisome organization, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	Dsl1p complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear envelope, peroxisome	molecular_function		
YLR441C	RPS1A	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein [Source:SGD;Acc:S000004433]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YLR442C	SIR3	Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p [Source:SGD;Acc:S000004434]	chromatin silencing at silent mating-type cassette, double-strand break repair via nonhomologous end joining, heterochromatin formation, loss of chromatin silencing involved in replicative cell aging, nuclear-transcribed mRNA catabolic process, non-stop decay	chromatin silencing complex, chromosome, telomeric region, mitochondrion, nuclear heterochromatin, nuclear telomere cap complex, nuclear telomeric heterochromatin, nucleolus, nucleus	DNA binding, chromatin binding, double-stranded DNA binding, nucleosomal histone binding, nucleosome binding, protein homodimerization activity, single-stranded DNA binding, structural constituent of chromatin		
YLR443W	ECM7	Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency [Source:SGD;Acc:S000004435]	calcium ion transport, cellular cell wall organization, fungal-type cell wall organization	integral to membrane, membrane	molecular_function		
YLR444C	YLR444C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004436]					
YLR445W	YLR445W	Putative protein of unknown function; transcription is regulated by Ume6p and induced in response to alpha factor [Source:SGD;Acc:S000004437]	biological_process	cellular_component	molecular_function		
YLR446W	YLR446W	Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene [Source:SGD;Acc:S000004438]	biological_process, carbohydrate metabolic process, glycolysis	cellular_component	ATP binding, hexokinase activity, kinase activity, molecular_function, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YLR447C	VMA6	Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane [Source:SGD;Acc:S000004439]	ATP hydrolysis coupled proton transport, ATP synthesis coupled proton transport, ion transport, proton transport, transport, vacuolar acidification, vacuolar transport	membrane, proton-transporting V-type ATPase, V0 domain, proton-transporting two-sector ATPase complex, proton-transporting domain, vacuolar membrane, vacuolar proton-transporting V-type ATPase, V0 domain, vacuole	hydrogen ion transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism		
YLR448W	RPL6B	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA [Source:SGD;Acc:S000004440]	ribosomal large subunit assembly, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YLR449W	FPR4	Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones [Source:SGD;Acc:S000004441]	chromatin silencing at rDNA, histone peptidyl-prolyl isomerization, negative regulation of histone H3-K36 methylation, nucleosome assembly, positive regulation of transcription from RNA polymerase II promoter, protein folding	chromatin, nucleus	histone binding, isomerase activity, macrolide binding, peptidyl-prolyl cis-trans isomerase activity		
YLR450W	HMG2	One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks [Source:SGD;Acc:S000004442]	cholesterol biosynthetic process, coenzyme A metabolic process, ergosterol biosynthetic process, isoprenoid biosynthetic process, lipid biosynthetic process, oxidation-reduction process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear envelope	NADP binding, coenzyme binding, hydroxymethylglutaryl-CoA reductase (NADPH) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YLR451W	LEU3	Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis [Source:SGD;Acc:S000004443]	branched chain family amino acid biosynthetic process, cellular amino acid biosynthetic process, leucine biosynthetic process, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YLR452C	SST2	GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family [Source:SGD;Acc:S000004444]	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, intracellular signal transduction, negative regulation of signal transduction, response to pheromone, signal transduction	plasma membrane	GTPase activator activity, signal transducer activity		
YLR453C	RIF2	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation [Source:SGD;Acc:S000004445]	telomere capping, telomere maintenance via telomerase	chromosome, telomeric region, nuclear telomere cap complex, nucleus	telomeric DNA binding		
YLR454W	FMP27	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004446]	biological_process	mitochondrion	molecular_function		
YLR455W	YLR455W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000004447]	biological_process	nucleus	molecular_function		
YLR456W	YLR456W	Putative protein of unknown function; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 [Source:SGD;Acc:S000004448]	biological_process	cellular_component, cytoplasm, nucleus	FMN binding, molecular_function		
YLR457C	NBP1	Spindle pole body (SPB) component, required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex [Source:SGD;Acc:S000004449]	spindle pole body duplication in nuclear envelope	central plaque of spindle pole body, nucleus, spindle pole body	molecular_function		
YLR458W	YLR458W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis [Source:SGD;Acc:S000004450]					
YLR459W	GAB1	GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI [Source:SGD;Acc:S000004451]	GPI anchor biosynthetic process, attachment of GPI anchor to protein, cell cycle, cell division	GPI-anchor transamidase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	GPI-anchor transamidase activity		
YLR460C	YLR460C	Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine [Source:SGD;Acc:S000004452]	biological_process, metabolic process, oxidation-reduction process	cellular_component	binding, catalytic activity, molecular_function, oxidoreductase activity, zinc ion binding		
YLR461W	PAU4	Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme [Source:SGD;Acc:S000004453]	biological_process, response to stress	cellular_component, integral to membrane, membrane	molecular_function		
YLR462W	YLR462W	Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII [Source:SGD;Acc:S000004454]	biological_process	cellular_component	molecular_function		
YLR463C	YLR463C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORFs YLR462W and YLR464W [Source:SGD;Acc:S000004455]					
YLR464W	YLR464W	Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C [Source:SGD;Acc:S000004456]	biological_process	cellular_component	molecular_function		
YLR465C	BSC3	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4 [Source:SGD;Acc:S000004457]					
YLR466C-A	YLR466C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W [Source:SGD;Acc:S000028685]					
YLR466C-B	YLR466C-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028686]	biological_process	cellular_component	molecular_function		
YLR466W	YRF1-4	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000004458]	telomere maintenance via recombination	nucleus	ATP binding, ATP-dependent helicase activity, DNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YLR467C-A	YLR467C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W [Source:SGD;Acc:S000028687]					
YLR467W	YRF1-5	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000004459]	telomere maintenance via recombination	nucleus	ATP binding, ATP-dependent helicase activity, DNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YML001W	YPT7	Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7 [Source:SGD;Acc:S000004460]	Golgi to vacuole transport, endocytosis, piecemeal microautophagy of nucleus, protein transport, regulation of vacuole fusion, non-autophagic, small GTPase mediated signal transduction, transport, vacuole inheritance, vesicle-mediated transport	fungal-type vacuole, mitochondrial outer membrane, vacuole	GTP binding, GTPase activity, nucleotide binding		
YML002W	YML002W	Putative protein of unknown function; expression induced by heat and by calcium shortage [Source:SGD;Acc:S000004461]	biological_process	cellular_component	molecular_function, protein binding		
YML003W	YML003W	Putative protein of unknown function [Source:SGD;Acc:S000004462]	biological_process	cellular_component	molecular_function		
YML004C	GLO1	Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress [Source:SGD;Acc:S000004463]	glutathione metabolic process, methylglyoxal catabolic process to D-lactate	cytoplasm, nucleus	lactoylglutathione lyase activity, lyase activity, metal ion binding		
YML005W	TRM12	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA [Source:SGD;Acc:S000004464]	tRNA methylation, tRNA processing, wybutosine biosynthetic process	cytoplasm	S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups		
YML006C	GIS4	CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway [Source:SGD;Acc:S000004465]	cellular ion homeostasis, intracellular signal transduction	cytoplasm, plasma membrane	molecular_function		
YML007C-A	YML007C-A	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria [Source:SGD;Acc:S000007621]	biological_process	mitochondrion	molecular_function		
YML007W	YAP1	Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium [Source:SGD;Acc:S000004466]	regulation of transcription from RNA polymerase II promoter in response to oxidative stress, regulation of transcription, DNA-dependent, response to arsenic-containing substance, response to cadmium ion, response to drug, response to heat, response to metal ion, response to singlet oxygen	cytoplasm, nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YML008C	ERG6	Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane [Source:SGD;Acc:S000004467]	ergosterol biosynthetic process, lipid biosynthetic process, metabolic process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, lipid particle, mitochondrial outer membrane, mitochondrion	methyltransferase activity, sterol 24-C-methyltransferase activity, transferase activity		
YML009C	MRPL39	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004468]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YML009C-A	YML009C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004469]					
YML009W-B	YML009W-B	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition [Source:SGD;Acc:S000004471]					
YML010W	SPT5	Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing; forms a complex with Spt4p; contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p [Source:SGD;Acc:S000004470]	chromatin organization, mRNA processing, positive regulation of transcription elongation from RNA polymerase II promoter, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, transcription elongation from RNA polymerase II promoter, transcription from RNA polymerase I promoter, transcription-coupled nucleotide-excision repair	DSIF complex, mitochondrion, nucleus, rDNA heterochromatin, transcription elongation factor complex			
YML011C	RAD33	Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus [Source:SGD;Acc:S000004472]	DNA repair, nucleotide-excision repair, response to DNA damage stimulus	nucleus	molecular_function		
YML012C-A	YML012C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 [Source:SGD;Acc:S000004474]					
YML012W	ERV25	Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport [Source:SGD;Acc:S000004473]	ER to Golgi vesicle-mediated transport, protein transport, transport, vesicle-mediated transport	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YML013W	UBX2	Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain [Source:SGD;Acc:S000004475]	ER-associated protein catabolic process, proteasomal ubiquitin-dependent protein catabolic process, protein secretion	Doa10p ubiquitin ligase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrial outer membrane	protein binding, protein binding, bridging		
YML014W	TRM9	tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p; deletion confers resistance to zymocin [Source:SGD;Acc:S000004476]	chronological cell aging, metabolic process, response to stress, tRNA methylation, tRNA wobble uridine modification	cytoplasm, nucleus	methyltransferase activity, tRNA (uracil) methyltransferase activity, transferase activity		
YML015C	TAF11	TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors [Source:SGD;Acc:S000004477]	RNA polymerase II transcriptional preinitiation complex assembly, transcription initiation from RNA polymerase II promoter	nucleus, transcription factor TFIID complex	DNA binding, chromatin binding		
YML016C	PPZ1	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance [Source:SGD;Acc:S000004478]	cellular protein localization, cellular sodium ion homeostasis, protein dephosphorylation	cytoplasm, extrinsic to plasma membrane, nucleus	cofactor binding, hydrolase activity, magnesium-dependent protein serine/threonine phosphatase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YML017W	PSP2	Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing [Source:SGD;Acc:S000004479]	biological_process	cytoplasm	molecular_function		
YML018C	YML018C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene [Source:SGD;Acc:S000004480]	biological_process, transmembrane transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YML019W	OST6	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p [Source:SGD;Acc:S000004481]	protein N-linked glycosylation via asparagine, protein complex assembly	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity, transferase activity		
YML020W	YML020W	Putative protein of unknown function [Source:SGD;Acc:S000004482]	biological_process	cellular_component	molecular_function		
YML021C	UNG1	Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus [Source:SGD;Acc:S000004483]	DNA repair, base-excision repair, metabolic process, response to DNA damage stimulus	mitochondrion, nucleus	hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing N-glycosyl compounds, uracil DNA N-glycosylase activity		
YML022W	APT1	Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis [Source:SGD;Acc:S000004484]	AMP biosynthetic process, adenine salvage, nucleoside metabolic process, purine ribonucleoside salvage	cytoplasm, nucleus	adenine phosphoribosyltransferase activity, metal ion binding, transferase activity, transferase activity, transferring glycosyl groups		
YML023C	NSE5	Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repair [Source:SGD;Acc:S000004485]	DNA recombination, DNA repair, response to DNA damage stimulus	Smc5-Smc6 complex, nucleus	molecular_function		
YML024W	RPS17A	Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein [Source:SGD;Acc:S000004486]	ribosomal small subunit assembly, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YML025C	YML6	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins [Source:SGD;Acc:S000004487]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YML026C	RPS18B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins [Source:SGD;Acc:S000004488]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA export from nucleus, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, nucleic acid binding, rRNA binding, structural constituent of ribosome		
YML027W	YOX1	Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate [Source:SGD;Acc:S000004489]	cell cycle, negative regulation of transcription from RNA polymerase II promoter, regulation of mitotic cell cycle, regulation of transcription, DNA-dependent	nuclear chromatin, nucleus	DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YML028W	TSA1	Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype [Source:SGD;Acc:S000004490]	DNA damage checkpoint, DNA protection, cell redox homeostasis, cellular response to oxidative stress, oxidation-reduction process, protein folding, regulation of translation, replicative cell aging, response to hydroperoxide	cytoplasm, cytosol, polysome	antioxidant activity, oxidoreductase activity, peroxidase activity, peroxiredoxin activity, ribosome binding, thioredoxin peroxidase activity, unfolded protein binding		
YML029W	USA1	Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p [Source:SGD;Acc:S000004491]	ER-associated protein catabolic process, RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	Hrd1p ubiquitin ligase ERAD-L complex, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YML030W	AIM31	Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; may interact with respiratory chain complexes III or IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000004492]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YML031C-A	YML031C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF NDC1/YML031W; questionable ORF from MIPS [Source:SGD;Acc:S000028809]					
YML031W	NDC1	Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II [Source:SGD;Acc:S000004493]	mRNA transport, nuclear pore organization, protein transport, spindle pole body duplication in nuclear envelope, transmembrane transport, transport	NDC1 complex, cytoplasm, cytoskeleton, integral to membrane, membrane, nuclear membrane, nuclear pore, nucleus, spindle pole body	structural constituent of cytoskeleton		
YML032C	RAD52	Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis [Source:SGD;Acc:S000004494]	DNA recombinase assembly, DNA recombination, DNA repair, double-strand break repair via break-induced replication, double-strand break repair via single-strand annealing, double-strand break repair via synthesis-dependent strand annealing, meiotic DNA recombinase assembly, meiotic joint molecule formation, postreplication repair, response to DNA damage stimulus, telomere maintenance via recombination	nuclear chromosome, nucleus	DNA strand annealing activity, recombinase activity		
YML034C-A	YML034C-A	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004499]					
YML034W	SRC1	Inner nuclear membrane protein that functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; mutant has aneuploidy tolerance [Source:SGD;Acc:S000004497]	maintenance of rDNA, mitotic sister chromatid segregation	integral to membrane, membrane, nuclear envelope, nuclear inner membrane, nucleus	molecular_function		
YML035C	AMD1	AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools [Source:SGD;Acc:S000004498]	nucleotide metabolic process, purine base metabolic process, purine nucleotide metabolic process, purine ribonucleoside monophosphate biosynthetic process	cytoplasm	AMP deaminase activity, deaminase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, metal ion binding		
YML036W	CGI121	Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification [Source:SGD;Acc:S000004500]	positive regulation of transcription from RNA polymerase II promoter, telomere maintenance	EKC/KEOPS complex, chromosome, telomeric region, nucleus	molecular_function		
YML037C	YML037C	Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene [Source:SGD;Acc:S000004501]	biological_process	clathrin-coated vesicle	molecular_function		
YML038C	YMD8	Putative nucleotide sugar transporter, has similarity to Vrg4p [Source:SGD;Acc:S000004502]	UDP-glucose transport, carbohydrate transport, nucleotide-sugar transport, transport	COPI coated vesicle membrane, COPI-coated vesicle, Golgi apparatus, Golgi membrane, cytoplasmic vesicle, integral to membrane, membrane	nucleotide-sugar transmembrane transporter activity		
YML039W	YML039W	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000004503]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YML040W	YML040W	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000004504]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YML041C	VPS71	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting [Source:SGD;Acc:S000004505]	chromatin modification, chromatin remodeling, histone exchange, protein targeting to vacuole	Swr1 complex, nucleus	metal ion binding, nucleosome binding		
YML042W	CAT2	Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes [Source:SGD;Acc:S000004506]	carnitine metabolic process, fatty acid metabolic process, lipid metabolic process, transport	membrane, mitochondrial inner membrane, mitochondrion, peroxisomal matrix, peroxisome	acyltransferase activity, carnitine O-acetyltransferase activity, transferase activity		
YML043C	RRN11	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p [Source:SGD;Acc:S000004507]	transcription from RNA polymerase I promoter, transcription initiation from RNA polymerase I promoter, transcription of nuclear rRNA large RNA polymerase I transcript	RNA polymerase I core factor complex, nucleolus, nucleus			
YML045W	YML045W	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000004508]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YML045W-A	YML045W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007381]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YML046W	PRP39	U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats [Source:SGD;Acc:S000004509]	RNA processing, RNA splicing, mRNA processing, nuclear mRNA 5'-splice site recognition	U1 snRNP, U2-type prespliceosome, commitment complex, intracellular, nucleus	pre-mRNA 5'-splice site binding		
YML047C	PRM6	Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating [Source:SGD;Acc:S000004510]	biological_process	integral to membrane, membrane	molecular_function		
YML047W-A	YML047W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004512]					
YML048W	GSF2	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression [Source:SGD;Acc:S000004511]	protein folding, protein localization at cell surface	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrial outer membrane	unfolded protein binding		
YML049C	RSE1	Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport [Source:SGD;Acc:S000004513]	RNA splicing, cell cycle, mRNA processing, nuclear mRNA splicing, via spliceosome, spliceosome assembly	U2 snRNP, U2-type prespliceosome, nucleus, spliceosomal complex	U2 snRNA binding, nucleic acid binding		
YML050W	AIM32	Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000004514]	biological_process	cellular_component	molecular_function		
YML051W	GAL80	Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding [Source:SGD;Acc:S000004515]	carbohydrate metabolic process, galactose metabolic process, metabolic process, negative regulation of kinase activity, positive regulation of transcription by galactose	cytoplasm, nucleus	DNA binding, binding, catalytic activity, kinase inhibitor activity, oxidoreductase activity		
YML052W	SUR7	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants [Source:SGD;Acc:S000004516]	ascospore formation, endocytosis, sporulation resulting in formation of a cellular spore	ascospore wall, cell cortex, eisosome, integral to membrane, membrane, membrane fraction, membrane raft, mitochondrion, plasma membrane	molecular_function		
YML053C	YML053C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene [Source:SGD;Acc:S000004517]	biological_process	cytoplasm, nucleus	molecular_function		
YML054C	CYB2	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions [Source:SGD;Acc:S000004518]	electron transport chain, lactate metabolic process, metabolic process, oxidation-reduction process, transport	mitochondrial intermembrane space, mitochondrion, respiratory chain	FMN binding, L-lactate dehydrogenase (cytochrome) activity, catalytic activity, heme binding, metal ion binding, oxidoreductase activity		
YML054C-A	YML054C-A	Putative protein of unknown function [Source:SGD;Acc:S000028573]	biological_process	cellular_component	molecular_function		
YML055W	SPC2	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 [Source:SGD;Acc:S000004519]	protein targeting to ER, signal peptide processing	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, signal peptidase complex	peptidase activity		
YML056C	IMD4	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed [Source:SGD;Acc:S000004520]	GMP biosynthetic process, biological_process, metabolic process, oxidation-reduction process, purine nucleotide biosynthetic process	cytoplasm	IMP dehydrogenase activity, catalytic activity, metal ion binding, oxidoreductase activity, protein binding		
YML057C-A	YML057C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W [Source:SGD;Acc:S000004522]					
YML057W	CMP2	Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 [Source:SGD;Acc:S000004521]	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, cellular ion homeostasis	calcineurin complex, cytoplasm	calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity		
YML058W	SML1	Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase [Source:SGD;Acc:S000004523]	cell cycle, mitochondrion organization, negative regulation of DNA replication, response to DNA damage stimulus	cytoplasm, nucleus	enzyme inhibitor activity		
YML058W-A	HUG1	Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage [Source:SGD;Acc:S000007472]	DNA repair, cell cycle arrest, cell cycle checkpoint, response to DNA damage stimulus	cytoplasm, nucleus	molecular_function		
YML059C	NTE1	Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes [Source:SGD;Acc:S000004524]	lipid catabolic process, lipid metabolic process, metabolic process, phosphatidylcholine catabolic process, phosphatidylcholine metabolic process, regulation of phospholipid biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	carboxylesterase activity, hydrolase activity, lysophospholipase activity		
YML060W	OGG1	Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance [Source:SGD;Acc:S000004525]	DNA repair, base-excision repair, base-excision repair, AP site formation, metabolic process, nucleotide-excision repair, response to DNA damage stimulus	mitochondrion, nucleus	DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity, catalytic activity, damaged DNA binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, lyase activity, oxidized purine base lesion DNA N-glycosylase activity		
YML061C	PIF1	DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis [Source:SGD;Acc:S000004526]	DNA recombination, DNA repair, chromosome organization, mitochondrial genome maintenance, negative regulation of telomere maintenance via telomerase, response to DNA damage stimulus, telomere maintenance	mitochondrial membrane, mitochondrion, nucleolus, nucleus	ATP binding, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, nucleotide binding, telomerase inhibitor activity		
YML062C	MFT1	Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance [Source:SGD;Acc:S000004527]	DNA recombination, mRNA export from nucleus, transcription elongation from RNA polymerase II promoter	THO complex part of transcription export complex, nucleoplasmic THO complex, nucleus	nucleic acid binding		
YML063W	RPS1B	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein [Source:SGD;Acc:S000004528]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YML064C	TEM1	GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis [Source:SGD;Acc:S000004529]	cell cycle, cell division, mitosis, regulation of exit from mitosis, small GTPase mediated signal transduction	spindle pole body	GTP binding, GTPase activity, nucleotide binding, protein binding		
YML065W	ORC1	Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity [Source:SGD;Acc:S000004530]	DNA replication, DNA-dependent DNA replication initiation, chromatin silencing at silent mating-type cassette, pre-replicative complex assembly	DNA replication preinitiation complex, nuclear origin of replication recognition complex, nucleus, origin recognition complex, pre-replicative complex	ATP binding, ATPase activity, DNA binding, DNA replication origin binding, chromatin binding, nucleoside-triphosphatase activity, nucleotide binding		
YML066C	SMA2	Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation [Source:SGD;Acc:S000004531]	ascospore wall assembly, spore membrane bending pathway, sporulation resulting in formation of a cellular spore	cytoplasm, endoplasmic reticulum, integral to membrane, membrane, prospore membrane	molecular_function		
YML067C	ERV41	Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein [Source:SGD;Acc:S000004532]	ER to Golgi vesicle-mediated transport, protein transport, transport, vesicle-mediated transport	ER to Golgi transport vesicle, ER-Golgi intermediate compartment membrane, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to Golgi membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YML068W	ITT1	Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins [Source:SGD;Acc:S000004533]	regulation of translation, regulation of translational termination	cellular_component	metal ion binding, molecular_function, protein binding, zinc ion binding		
YML069W	POB3	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases [Source:SGD;Acc:S000004534]	DNA repair, DNA replication, DNA replication-independent nucleosome organization, DNA-dependent DNA replication, positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, regulation of transcription by chromatin organization, response to DNA damage stimulus	FACT complex, alpha DNA polymerase:primase complex, chromosome, nuclear chromatin, nucleus, replication fork protection complex	DNA binding, chromatin binding, histone binding, nucleosome binding		
YML070W	DAK1	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation [Source:SGD;Acc:S000004535]	glycerol catabolic process, glycerol metabolic process, response to stress	cytoplasm	ATP binding, glycerone kinase activity, kinase activity, nucleotide binding, transferase activity		
YML071C	COG8	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000004536]	CVT pathway, intra-Golgi vesicle-mediated transport, protein transport, transport	Golgi apparatus, Golgi membrane, Golgi transport complex, membrane	molecular_function		
YML072C	TCB3	Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact [Source:SGD;Acc:S000004537]	biological_process	cellular bud, integral to membrane, membrane, mitochondrion, plasma membrane	calcium-dependent phospholipid binding, lipid binding, metal ion binding, protein binding		
YML073C	RPL6A	N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA [Source:SGD;Acc:S000004538]	ribosomal large subunit assembly, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YML074C	FPR3	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p [Source:SGD;Acc:S000004539]	meiotic recombination checkpoint, protein folding	nucleolus, nucleus	isomerase activity, macrolide binding, peptidyl-prolyl cis-trans isomerase activity		
YML075C	HMG1	One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae [Source:SGD;Acc:S000004540]	cholesterol biosynthetic process, coenzyme A metabolic process, ergosterol biosynthetic process, isopentenyl diphosphate biosynthetic process, mevalonate pathway, isoprenoid biosynthetic process, lipid biosynthetic process, oxidation-reduction process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear envelope	NADP binding, coenzyme binding, hydroxymethylglutaryl-CoA reductase (NADPH) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YML076C	WAR1	Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively [Source:SGD;Acc:S000004541]	regulation of transcription, DNA-dependent, response to acid	mitochondrion, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YML077W	BET5	Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi [Source:SGD;Acc:S000004542]	ER to Golgi vesicle-mediated transport, transport, vesicle-mediated transport	Golgi apparatus, TRAPP complex, cis-Golgi network, endoplasmic reticulum	Rab guanyl-nucleotide exchange factor activity		
YML078W	CPR3	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria [Source:SGD;Acc:S000004543]	apoptosis, protein folding	mitochondrial matrix, mitochondrion	isomerase activity, peptide binding, peptidyl-prolyl cis-trans isomerase activity		
YML079W	YML079W	Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm [Source:SGD;Acc:S000004544]	biological_process	cytoplasm, nucleus	molecular_function		
YML080W	DUS1	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 [Source:SGD;Acc:S000004545]	metabolic process, oxidation-reduction process, tRNA modification, tRNA processing	nucleus	catalytic activity, flavin adenine dinucleotide binding, oxidoreductase activity, tRNA dihydrouridine synthase activity		
YML081C-A	ATP18	Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms [Source:SGD;Acc:S000007247]	ATP biosynthetic process, ATP synthesis coupled proton transport, ion transport, mitochondrial proton-transporting ATP synthase complex assembly, proton transport, transport	integral to membrane, membrane, mitochondrial membrane, mitochondrial proton-transporting ATP synthase complex, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrion, proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism		
YML081W	YML081W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene [Source:SGD;Acc:S000004546]	biological_process	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YML082W	YML082W	Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene [Source:SGD;Acc:S000004547]	cellular amino acid biosynthetic process, cellular amino acid metabolic process, methionine biosynthetic process, sulfur compound metabolic process	cytoplasm, nucleus	carbon-sulfur lyase activity, catalytic activity, cystathionine gamma-synthase activity, pyridoxal phosphate binding, transferase activity		
YML083C	YML083C	Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions [Source:SGD;Acc:S000004548]	biological_process	cellular_component	molecular_function		
YML084W	YML084W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004549]					
YML085C	TUB1	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules [Source:SGD;Acc:S000004550]	homologous chromosome segregation, microtubule-based movement, microtubule-based process, mitotic sister chromatid segregation, nuclear migration along microtubule, nuclear migration involved in conjugation with cellular fusion, protein polymerization	cytoplasm, cytoplasmic microtubule, cytoskeleton, kinetochore microtubule, microtubule, nuclear microtubule, polar microtubule, protein complex, spindle pole body, tubulin complex	GTP binding, GTPase activity, nucleotide binding, structural constituent of cytoskeleton, structural molecule activity		
YML086C	ALO1	D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress [Source:SGD;Acc:S000004551]	biosynthetic process, cellular response to oxidative stress, dehydro-D-arabinono-1,4-lactone biosynthetic process, oxidation-reduction process	integral to mitochondrial outer membrane, membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion	D-arabinono-1,4-lactone oxidase activity, catalytic activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor		
YML087C	AIM33	Putative protein of unknown function, highly conserved across species and orthologous to human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000004552]	biological_process, oxidation-reduction process	cellular_component, integral to membrane, membrane	molecular_function, oxidoreductase activity		
YML088W	UFO1	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation [Source:SGD;Acc:S000004553]	response to DNA damage stimulus, ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex, cytoplasm, nucleus	protein binding, ubiquitin-protein ligase activity		
YML089C	YML089C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage [Source:SGD;Acc:S000004554]					
YML090W	YML090W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source [Source:SGD;Acc:S000004555]					
YML091C	RPM2	Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus [Source:SGD;Acc:S000004556]	RNA processing, mRNA processing, mitochondrion organization, positive regulation of transcription from RNA polymerase II promoter, tRNA 5'-leader removal, tRNA processing, translation	cytoplasmic mRNA processing body, mitochondrial ribonuclease P complex, mitochondrion, nucleus	endonuclease activity, hydrolase activity, nuclease activity, ribonuclease P activity		
YML092C	PRE8	Alpha 2 subunit of the 20S proteasome [Source:SGD;Acc:S000004557]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteolysis involved in cellular protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, mitochondrion, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, molecular_function, peptidase activity, threonine-type endopeptidase activity		
YML093W	UTP14	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit [Source:SGD;Acc:S000004558]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	ATP binding, molecular_function, nucleotide binding		
YML094C-A	YML094C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO [Source:SGD;Acc:S000004561]					
YML094W	GIM5	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it [Source:SGD;Acc:S000004559]	protein folding, tubulin complex assembly	cytoplasm, prefoldin complex	tubulin binding, unfolded protein binding		
YML095C	RAD10	Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein [Source:SGD;Acc:S000004560]	DNA repair, double-strand break repair via single-strand annealing, removal of nonhomologous ends, meiotic mismatch repair, mitotic recombination, nucleotide-excision repair, DNA incision, 5'-to lesion, removal of nonhomologous ends, response to DNA damage stimulus	nucleotide-excision repair factor 1 complex, nucleus	DNA binding, DNA strand annealing activity, damaged DNA binding, endonuclease activity, hydrolase activity, nuclease activity, single-stranded DNA binding, single-stranded DNA specific endodeoxyribonuclease activity		
YML096W	YML096W	Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 [Source:SGD;Acc:S000004562]	asparagine biosynthetic process, biological_process, cellular amino acid biosynthetic process, glutamine metabolic process	cytoplasm	asparagine synthase (glutamine-hydrolyzing) activity, molecular_function		
YML097C	VPS9	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin [Source:SGD;Acc:S000004563]	protein targeting to vacuole, vacuole inheritance	cytoplasm, cytosol	guanyl-nucleotide exchange factor activity, protein binding, ubiquitin binding		
YML098W	TAF13	TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors [Source:SGD;Acc:S000004564]	RNA polymerase II transcriptional preinitiation complex assembly, transcription from RNA polymerase II promoter	nucleus, transcription factor TFIID complex	DNA binding		
YML099C	ARG81	Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p [Source:SGD;Acc:S000004565]	arginine metabolic process, negative regulation of calcium ion-dependent exocytosis, regulation of transcription, DNA-dependent	cytoplasm, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, transcription cofactor activity, zinc ion binding		
YML099W-A	YML099W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ARG81/YML099C [Source:SGD;Acc:S000004567]					
YML100W	TSL1	Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, similar to Tps3p and may share function; mutant has aneuploidy tolerance [Source:SGD;Acc:S000004566]	response to stress, trehalose biosynthetic process	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming), cytoplasm	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, catalytic activity, enzyme regulator activity, trehalose-phosphatase activity		
YML100W-A	YML100W-A	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028688]	biological_process	cellular_component	molecular_function		
YML101C	CUE4	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination [Source:SGD;Acc:S000004568]	biological_process	cytoplasm, endoplasmic reticulum	molecular_function, protein binding		
YML101C-A	YML101C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004569]					
YML102W	CAC2	Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans [Source:SGD;Acc:S000004570]	DNA repair, DNA replication-dependent nucleosome assembly, chromatin silencing	CAF-1 complex, chromosome, centromeric region, nucleus	protein binding		
YML103C	NUP188	Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p [Source:SGD;Acc:S000004571]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YML104C	MDM1	Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) [Source:SGD;Acc:S000004572]	cell communication, mitochondrion inheritance, mitochondrion organization, nuclear migration	cytoplasm, intermediate filament	phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding, structural constituent of cytoskeleton		
YML105C	SEC65	Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19 [Source:SGD;Acc:S000004573]	SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, protein targeting to ER	cytoplasm, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting	7S RNA binding		
YML106W	URA5	Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10 [Source:SGD;Acc:S000004574]	'de novo' pyrimidine base biosynthetic process, nucleoside metabolic process, pyrimidine nucleotide biosynthetic process, pyrimidine ribonucleoside biosynthetic process	cytoplasm, nucleus	orotate phosphoribosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YML107C	PML39	Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes [Source:SGD;Acc:S000004575]	mRNA transport, maintenance of RNA location, transport	membrane, nuclear membrane, nuclear pore, nucleus, ribosome	molecular_function, zinc ion binding		
YML108W	YML108W	Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene [Source:SGD;Acc:S000004576]	biological_process	cytoplasm, nucleus	molecular_function		
YML109W	ZDS2	Protein with a role in regulating Swe1p-dependent polarized growth; interacts with Cdc55p; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p [Source:SGD;Acc:S000004577]	cell aging, cell shape checkpoint, chromatin silencing at rDNA, establishment of cell polarity, regulation of protein localization	cellular bud tip, nucleus	molecular_function		
YML110C	COQ5	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes [Source:SGD;Acc:S000004578]	aerobic respiration, ubiquinone biosynthetic process	mitochondrial matrix, mitochondrion	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity, methyltransferase activity, transferase activity		
YML111W	BUL2	Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1 [Source:SGD;Acc:S000004579]	protein monoubiquitination, protein polyubiquitination	cytoplasm, ubiquitin ligase complex			
YML112W	CTK3	Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity [Source:SGD;Acc:S000004580]	mRNA 3'-end processing, mRNA processing, positive regulation of transcription elongation, DNA-dependent, positive regulation of transcription from RNA polymerase I promoter, positive regulation of translational fidelity, protein phosphorylation, response to DNA damage stimulus	carboxy-terminal domain protein kinase complex, cytoplasm, nucleolus, nucleoplasm, nucleus	cyclin-dependent protein kinase activity		
YML113W	DAT1	DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability [Source:SGD;Acc:S000004581]	negative regulation of transcription from RNA polymerase II promoter	nucleus	AT DNA binding, DNA binding		
YML114C	TAF8	TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation [Source:SGD;Acc:S000004582]	RNA polymerase II transcriptional preinitiation complex assembly	nucleus, transcription factor TFIID complex			
YML115C	VAN1	Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant [Source:SGD;Acc:S000004583]	protein N-linked glycosylation, regulation of growth, sporulation resulting in formation of a cellular spore	Golgi apparatus, Golgi membrane, alpha-1,6-mannosyltransferase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	alpha-1,6-mannosyltransferase activity		
YML116W	ATR1	Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide [Source:SGD;Acc:S000004584]	borate transport, drug transmembrane transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane, vacuole	borate transmembrane transporter activity, drug transmembrane transporter activity		
YML116W-A	YML116W-A	Putative protein of unknown function [Source:SGD;Acc:S000004586]					
YML117W	NAB6	Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP [Source:SGD;Acc:S000004585]	biological_process	cytoplasm	RNA binding, molecular_function, nucleic acid binding, nucleotide binding		
YML118W	NGL3	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p [Source:SGD;Acc:S000004587]	biological_process	cellular_component	endonuclease activity, exonuclease activity, hydrolase activity, nuclease activity		
YML119W	YML119W	Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate [Source:SGD;Acc:S000004588]	biological_process	cellular_component	molecular_function		
YML120C	NDI1	NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID [Source:SGD;Acc:S000004589]	NADH oxidation, chronological cell aging, mitochondrial electron transport, NADH to ubiquinone, oxidation-reduction process, positive regulation of apoptosis	membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion	NADH dehydrogenase (ubiquinone) activity, flavin adenine dinucleotide binding, oxidoreductase activity		
YML121W	GTR1	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB [Source:SGD;Acc:S000004590]	chromatin silencing at telomere, phosphate transport, protein transport, transcription from RNA polymerase I promoter, transcription from RNA polymerase III promoter, transport	GSE complex, cytoplasm, late endosome membrane, membrane, nucleus, vacuolar membrane, vacuole	GDP binding, GTP binding, nucleotide binding		
YML122C	YML122C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004591]					
YML123C	PHO84	High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p [Source:SGD;Acc:S000004592]	manganese ion transport, phosphate transport, polyphosphate metabolic process, transmembrane transport, transport	integral to membrane, integral to plasma membrane, membrane	inorganic phosphate transmembrane transporter activity, manganese ion transmembrane transporter activity, transporter activity		
YML124C	TUB3	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p [Source:SGD;Acc:S000004593]	homologous chromosome segregation, microtubule-based movement, microtubule-based process, mitotic sister chromatid segregation, nuclear migration along microtubule, nuclear migration involved in conjugation with cellular fusion, protein polymerization	cytoplasm, cytoplasmic microtubule, cytoskeleton, kinetochore microtubule, microtubule, nuclear microtubule, polar microtubule, protein complex, spindle pole body, tubulin complex	GTP binding, GTPase activity, nucleotide binding, structural constituent of cytoskeleton, structural molecule activity		
YML125C	PGA3	Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking [Source:SGD;Acc:S000004594]	chronological cell aging, oxidation-reduction process, protein transport, replicative cell aging	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, plasma membrane	molecular_function, oxidoreductase activity		
YML126C	ERG13	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis [Source:SGD;Acc:S000004595]	ergosterol biosynthetic process, isoprenoid biosynthetic process, lipid biosynthetic process, metabolic process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum	catalytic activity, hydroxymethylglutaryl-CoA synthase activity, transferase activity		
YML127W	RSC9	Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway [Source:SGD;Acc:S000004596]	ATP-dependent chromatin remodeling, G2/M transition of mitotic cell cycle, chromatin modification, chromatin remodeling, nucleosome disassembly, rRNA processing, rRNA transcription, regulation of transcription from RNA polymerase II promoter, response to stress, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	DNA-dependent ATPase activity, binding, chromatin binding		
YML128C	MSC1	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated [Source:SGD;Acc:S000004597]	reciprocal meiotic recombination	endoplasmic reticulum, mitochondrion, plasma membrane enriched fraction	molecular_function		
YML129C	COX14	Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes [Source:SGD;Acc:S000004598]	negative regulation of mitochondrial translation	extrinsic to membrane, integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion	molecular_function		
YML130C	ERO1	Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum [Source:SGD;Acc:S000004599]	electron transport chain, oxidation-reduction process, protein folding, protein thiol-disulfide exchange, transport	endoplasmic reticulum, endoplasmic reticulum membrane, membrane	electron carrier activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor, thiol oxidase activity		
YML131W	YML131W	Putative protein of unknown function with similarity to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000004600]	biological_process, metabolic process, oxidation-reduction process	cytoplasm, integral to membrane, membrane	binding, catalytic activity, molecular_function, oxidoreductase activity, zinc ion binding		
YML132W	COS3	Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000004601]	cellular sodium ion homeostasis	fungal-type vacuole, integral to membrane, membrane, membrane fraction	molecular_function		
YML133C	YML133C	Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron [Source:SGD;Acc:S000004602]	biological_process	mitochondrion	ATP binding, ATP-dependent helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YML133W-A	YML133W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C [Source:SGD;Acc:S000028689]					
YML133W-B	YML133W-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C [Source:SGD;Acc:S000028690]					
YMR001C	CDC5	Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate [Source:SGD;Acc:S000004603]	DNA-dependent DNA replication, cell cycle, cell division, mitosis, positive regulation of spindle pole body separation, protein phosphorylation, resolution of meiotic recombination intermediates, spindle assembly involved in meiosis, synaptonemal complex disassembly	cellular bud neck, nucleus, spindle pole	ATP binding, kinase activity, nucleotide binding, polo kinase kinase activity, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YMR001C-A	YMR001C-A	Putative protein of unknown function [Source:SGD;Acc:S000028691]	biological_process	cellular_component	molecular_function		
YMR002W	MIC17	Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000004604]	aerobic respiration	cytoplasm, mitochondrial intermembrane space, mitochondrion, nucleus	molecular_function		
YMR003W	AIM34	Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000004605]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function, nucleic acid binding		
YMR004W	MVP1	Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole [Source:SGD;Acc:S000004606]	cell communication, protein targeting to vacuole, protein transport, transport	cytoplasm	phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding		
YMR005W	TAF4	TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate [Source:SGD;Acc:S000004607]	RNA polymerase II transcriptional preinitiation complex assembly, transcription initiation, DNA-dependent	nucleus, transcription factor TFIID complex	chromatin binding		
YMR006C	PLB2	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine [Source:SGD;Acc:S000004608]	glycerophospholipid metabolic process, lipid catabolic process, metabolic process, phospholipid catabolic process	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	hydrolase activity, lysophospholipase activity, phospholipase activity		
YMR007W	YMR007W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004609]					
YMR008C	PLB1	Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol [Source:SGD;Acc:S000004610]	glycerophospholipid metabolic process, lipid catabolic process, metabolic process, phospholipid catabolic process	anchored to membrane, fungal-type cell wall, membrane, plasma membrane, plasma membrane enriched fraction	hydrolase activity, lysophospholipase activity, phospholipase activity		
YMR009W	ADI1	Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions [Source:SGD;Acc:S000004611]	L-methionine salvage from methylthioadenosine, cellular amino acid biosynthetic process, methionine biosynthetic process, oxidation-reduction process	cytoplasm, membrane, nucleus, plasma membrane	dioxygenase activity, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen		
YMR010W	YMR010W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 [Source:SGD;Acc:S000004612]	biological_process	cytoplasm, integral to membrane, membrane	molecular_function		
YMR011W	HXT2	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose [Source:SGD;Acc:S000004613]	carbohydrate transport, glucose transport, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, plasma membrane	fructose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, pentose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YMR012W	CLU1	eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant [Source:SGD;Acc:S000004614]	mitochondrion organization, translational initiation	cytoplasm, eukaryotic translation initiation factor 3 complex	binding, molecular_function		
YMR013C	SEC59	Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation [Source:SGD;Acc:S000004615]	protein glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichol kinase activity, kinase activity, transferase activity, transferase activity, transferring phosphorus-containing groups		
YMR013C-A	YMR013C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF SEC59/YML013C [Source:SGD;Acc:S000028847]					
YMR013W-A	YMR013W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73 [Source:SGD;Acc:S000007622]					
YMR014W	BUD22	Protein required for 18S rRNA maturation and small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern [Source:SGD;Acc:S000004616]	maturation of SSU-rRNA, ribosomal small subunit biogenesis	90S preribosome, nucleus	molecular_function		
YMR015C	ERG5	C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs [Source:SGD;Acc:S000004617]	ergosterol biosynthetic process, lipid biosynthetic process, oxidation-reduction process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum	C-22 sterol desaturase activity, electron carrier activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity		
YMR016C	SOK2	Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors [Source:SGD;Acc:S000004618]	pseudohyphal growth, regulation of transcription, DNA-dependent	nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YMR017W	SPO20	Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog [Source:SGD;Acc:S000004619]	ascospore-type prospore formation, sporulation resulting in formation of a cellular spore	membrane, plasma membrane, prospore membrane	SNAP receptor activity, protein binding		
YMR018W	YMR018W	Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene [Source:SGD;Acc:S000004620]	biological_process	cellular_component	binding, molecular_function, protein binding		
YMR019W	STB4	Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters [Source:SGD;Acc:S000004621]	biological_process, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YMR020W	FMS1	Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis [Source:SGD;Acc:S000004622]	oxidation-reduction process, pantothenate biosynthetic process, polyamine catabolic process	cytoplasm	oxidoreductase activity, polyamine oxidase activity		
YMR021C	MAC1	Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport [Source:SGD;Acc:S000004623]	cellular cadmium ion homeostasis, positive regulation of transcription from RNA polymerase II promoter, regulation of protein catabolic process, regulation of transcription, DNA-dependent	nucleus	DNA binding, copper ion binding, metal ion binding, sequence-specific DNA binding transcription factor activity		
YMR022W	UBC7	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly [Source:SGD;Acc:S000004624]	ER-associated protein catabolic process, chromatin assembly or disassembly, fungal-type cell wall organization, post-translational protein modification, regulation of protein metabolic process, response to cadmium ion	endoplasmic reticulum, endoplasmic reticulum membrane, membrane	ATP binding, acid-amino acid ligase activity, ligase activity, nucleotide binding, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YMR023C	MSS1	Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 [Source:SGD;Acc:S000004625]	mitochondrial tRNA wobble uridine modification, small GTPase mediated signal transduction, tRNA modification, tRNA processing	intracellular, mitochondrial inner membrane, mitochondrion	GTP binding, GTPase activity, nucleotide binding		
YMR024W	MRPL3	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004626]	RNA processing, mitochondrial translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, double-stranded RNA binding, ribonuclease III activity, structural constituent of ribosome		
YMR025W	CSI1	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling [Source:SGD;Acc:S000004627]	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, cullin deneddylation	cytoplasm, nucleus, signalosome	molecular_function		
YMR026C	PEX12	C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder [Source:SGD;Acc:S000004628]	peroxisome organization, protein import into peroxisome matrix, protein transport, transport	integral to membrane, integral to peroxisomal membrane, membrane, peroxisomal membrane, peroxisome	metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YMR027W	YMR027W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene [Source:SGD;Acc:S000004629]	biological_process	cytoplasm, nucleus	molecular_function		
YMR028W	TAP42	Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits [Source:SGD;Acc:S000004630]	TOR signaling cascade, negative regulation of signal transduction, positive regulation of transcription from RNA polymerase I promoter, regulation of signal transduction, response to biotic stimulus	peripheral to membrane of membrane fraction, soluble fraction	molecular_function		
YMR029C	FAR8	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p [Source:SGD;Acc:S000004631]	cell cycle, re-entry into mitotic cell cycle after pheromone arrest	cellular_component, cytoplasm, endoplasmic reticulum	molecular_function, protein binding		
YMR030W	RSF1	Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes [Source:SGD;Acc:S000004632]	aerobic respiration, calcium-mediated signaling, transcription from RNA polymerase II promoter, transcription from mitochondrial promoter	cytoplasm, mitochondrion, nucleus	molecular_function		
YMR030W-A	YMR030W-A	Putative protein of unknown function [Source:SGD;Acc:S000028574]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YMR031C	EIS1	Component of the eisosome that is required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004633]	eisosome assembly	cytoplasm, eisosome, membrane raft, mitochondrion	molecular_function		
YMR031W-A	YMR031W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C [Source:SGD;Acc:S000004634]					
YMR032W	HOF1	Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p [Source:SGD;Acc:S000004635]	cell cycle, cell division, cytokinesis, mitosis, response to DNA damage stimulus	cellular bud neck, cellular bud neck contractile ring, cytoplasm, cytoskeleton	cytoskeletal protein binding, protein binding		
YMR033W	ARP9	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation [Source:SGD;Acc:S000004636]	ATP-dependent chromatin remodeling, chromatin modification, chromatin organization, nucleosome disassembly, nucleosome mobilization, transcription elongation from RNA polymerase II promoter	RSC complex, SWI/SNF complex, nucleus	DNA-dependent ATPase activity		
YMR034C	YMR034C	Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene [Source:SGD;Acc:S000004637]	biological_process	cellular_component, integral to membrane, membrane	sterol transporter activity		
YMR035W	IMP2	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p [Source:SGD;Acc:S000004638]	protein processing involved in protein targeting to mitochondrion, proteolysis	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial inner membrane peptidase complex, mitochondrion	endopeptidase activity, hydrolase activity, peptidase activity, serine-type peptidase activity		
YMR036C	MIH1	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25 [Source:SGD;Acc:S000004639]	G2/M transition of mitotic cell cycle, M phase of mitotic cell cycle, cell cycle, cell division, mitosis, protein dephosphorylation, regulation of cyclin-dependent protein kinase activity	cytoplasm, intracellular, nucleus	hydrolase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity		
YMR037C	MSN2	Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression [Source:SGD;Acc:S000004640]	age-dependent response to oxidative stress involved in chronological cell aging, cellular response to glucose starvation, cellular response to oxidative stress, heat acclimation, regulation of transcription from RNA polymerase II promoter in response to stress, replicative cell aging, response to freezing, response to hydrostatic pressure, response to osmotic stress, response to stress	cytoplasm, cytosol, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YMR038C	CCS1	Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation [Source:SGD;Acc:S000004641]	intracellular copper ion transport, metal ion transport, oxidation-reduction process, superoxide metabolic process	cytoplasm, cytosol, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, nucleus	metal ion binding, superoxide dismutase copper chaperone activity		
YMR039C	SUB1	Transcriptional coactivator, facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes [Source:SGD;Acc:S000004642]	RNA polymerase III transcriptional preinitiation complex assembly, hyperosmotic response, positive regulation of transcription elongation from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase III promoter, regulation of transcription from RNA polymerase II promoter in response to stress, regulation of transcription, DNA-dependent, termination of RNA polymerase II transcription	nucleus	DNA binding, binding, transcription coactivator activity		
YMR040W	YET2	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein [Source:SGD;Acc:S000004643]	biological_process, intracellular protein transport, protein transport, transport, vesicle-mediated transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, ribosome	molecular_function		
YMR041C	ARA2	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase [Source:SGD;Acc:S000004644]	dehydro-D-arabinono-1,4-lactone biosynthetic process, oxidation-reduction process	cellular_component	D-arabinose 1-dehydrogenase (NAD) activity, D-arabinose 1-dehydrogenase [NAD(P)+] activity, oxidoreductase activity		
YMR042W	ARG80	Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p [Source:SGD;Acc:S000004645]	arginine metabolic process, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YMR043W	MCM1	Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes [Source:SGD;Acc:S000004646]	DNA-dependent DNA replication initiation, cell cycle, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nuclear chromatin, nucleus	DNA bending activity, DNA binding, DNA replication origin binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YMR044W	IOC4	Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif [Source:SGD;Acc:S000004647]	chromatin remodeling	ISW1 complex, nucleus	ATPase activity, DNA binding, nucleosome binding		
YMR045C	YMR045C	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000004648]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YMR046C	YMR046C	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000004649]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YMR046W-A	YMR046W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007248]					
YMR047C	NUP116	Subunit of the Nup82 subcomplex of the nuclear pore complex; localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p [Source:SGD;Acc:S000004650]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein import into nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, tRNA splicing, via endonucleolytic cleavage and ligation, transmembrane transport, transport	Nup82 complex, membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YMR048W	CSM3	Replication fork associated factor, required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis [Source:SGD;Acc:S000004651]	DNA repair, DNA replication checkpoint, cell cycle, establishment of mitotic sister chromatid cohesion, maintenance of DNA repeat elements, meiosis, meiotic chromosome segregation, mitotic sister chromatid cohesion, negative regulation of DNA replication, replication fork arrest, replication fork protection, response to DNA damage stimulus	nucleus, replication fork protection complex	molecular_function		
YMR049C	ERB1	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 [Source:SGD;Acc:S000004652]	rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis	PeBoW complex, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor	molecular_function, protein binding		
YMR050C	YMR050C	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000004653]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YMR051C	YMR051C	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000004654]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YMR052C-A	YMR052C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004655]					
YMR052W	FAR3	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum [Source:SGD;Acc:S000004656]	cell cycle, re-entry into mitotic cell cycle after pheromone arrest	endoplasmic reticulum	molecular_function		
YMR053C	STB2	Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p [Source:SGD;Acc:S000004657]	histone deacetylation	Sin3-type complex, nucleus			
YMR054W	STV1	Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole [Source:SGD;Acc:S000004658]	ATP synthesis coupled proton transport, ion transport, proton transport, transport, vacuolar acidification	Golgi apparatus, Golgi membrane, endosome, endosome membrane, integral to membrane, late endosome, membrane, proton-transporting two-sector ATPase complex, proton-transporting domain, vacuolar proton-transporting V-type ATPase, V0 domain	hydrogen ion transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism		
YMR055C	BUB2	Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage [Source:SGD;Acc:S000004659]	cell cycle, cell division, mitosis, mitotic cell cycle spindle orientation checkpoint, regulation of Rab GTPase activity, regulation of exit from mitosis	cytoplasm, cytoskeleton, intracellular, spindle pole, spindle pole body	GTPase activator activity, Rab GTPase activator activity		
YMR056C	AAC1	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator [Source:SGD;Acc:S000004660]	aerobic respiration, heme biosynthetic process, heme transport, mitochondrial transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	ATP:ADP antiporter activity, binding, transporter activity		
YMR057C	YMR057C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 [Source:SGD;Acc:S000004661]					
YMR058W	FET3	Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases [Source:SGD;Acc:S000004662]	high-affinity iron ion transport, ion transport, iron assimilation by reduction and transport, iron ion transport, oxidation-reduction process, response to copper ion, transport	high affinity iron permease complex, integral to membrane, membrane, plasma membrane	copper ion binding, ferroxidase activity, iron ion transmembrane transporter activity, metal ion binding, oxidoreductase activity		
YMR059W	SEN15	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p [Source:SGD;Acc:S000004663]	tRNA processing, tRNA-type intron splice site recognition and cleavage	endomembrane system, membrane, mitochondrial outer membrane, mitochondrion, nucleus, tRNA-intron endonuclease complex	tRNA-intron endonuclease activity		
YMR060C	SAM37	Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability [Source:SGD;Acc:S000004664]	mitochondrial outer membrane translocase complex assembly, phospholipid transport, protein import into mitochondrial outer membrane, protein targeting to mitochondrion, protein transport, transport	integral to membrane, membrane, mitochondrial outer membrane, mitochondrial sorting and assembly machinery complex, mitochondrion	molecular_function		
YMR061W	RNA14	Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex [Source:SGD;Acc:S000004665]	RNA processing, mRNA cleavage, mRNA polyadenylation, mRNA processing	cytoplasm, intracellular, mRNA cleavage factor complex, mitochondrion, nucleus	RNA binding, binding, protein heterodimerization activity		
YMR062C	ARG7	Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine [Source:SGD;Acc:S000004666]	arginine biosynthetic process, cellular amino acid biosynthetic process, fungal-type cell wall organization, ornithine biosynthetic process	mitochondrial matrix, mitochondrion	acetyl-CoA:L-glutamate N-acetyltransferase activity, acyltransferase activity, catalytic activity, glutamate N-acetyltransferase activity, transferase activity		
YMR063W	RIM9	Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein [Source:SGD;Acc:S000004667]	ascospore formation	cellular_component, integral to membrane, membrane, plasma membrane	molecular_function		
YMR064W	AEP1	Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase [Source:SGD;Acc:S000004668]	translation	mitochondrion	molecular_function		
YMR065W	KAR5	Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone [Source:SGD;Acc:S000004669]	karyogamy, karyogamy involved in conjugation with cellular fusion	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion, nuclear membrane, nucleus	molecular_function		
YMR066W	SOV1	Mitochondrial protein of unknown function [Source:SGD;Acc:S000004670]	biological_process	mitochondrion	molecular_function		
YMR067C	UBX4	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p [Source:SGD;Acc:S000004671]	sporulation resulting in formation of a cellular spore, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus	molecular_function, protein binding		
YMR068W	AVO2	Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth [Source:SGD;Acc:S000004672]	TOR signaling cascade, establishment or maintenance of actin cytoskeleton polarity, fungal-type cell wall organization, regulation of cell growth	TORC2 complex, cytoplasm, membrane, plasma membrane, vacuolar membrane, vacuole	molecular_function, protein binding		
YMR069W	NAT4	N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A [Source:SGD;Acc:S000004673]	histone acetylation, metabolic process	cytoplasm, nucleus	N-acetyltransferase activity, acyltransferase activity, histone acetyltransferase activity, transferase activity		
YMR070W	MOT3	Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes [Source:SGD;Acc:S000004674]	negative regulation of transcription from RNA polymerase II promoter	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YMR071C	TVP18	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000004675]	vesicle-mediated transport	Golgi apparatus, Golgi membrane, clathrin-coated vesicle, integral to Golgi membrane, integral to membrane, membrane	molecular_function		
YMR072W	ABF2	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation [Source:SGD;Acc:S000004676]	mitochondrial genome maintenance, mitochondrion inheritance	mitochondrial chromosome, mitochondrial nucleoid, mitochondrion, nucleus	DNA bending activity, DNA binding, protein binding		
YMR073C	IRC21	Putative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000004677]	response to drug	cytoplasm	heme binding, metal ion binding, molecular_function		
YMR074C	YMR074C	Protein with homology to human PDCD5, which is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene [Source:SGD;Acc:S000004678]	apoptosis	cytoplasm, nucleus	DNA binding, molecular_function		
YMR075C-A	YMR075C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W [Source:SGD;Acc:S000004679]					
YMR075W	RCO1	Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p [Source:SGD;Acc:S000004680]	chromatin modification, histone deacetylation, negative regulation of antisense RNA transcription, regulation of DNA-dependent DNA replication initiation, transcription elongation from RNA polymerase II promoter	Rpd3S complex, histone deacetylase complex, nucleus	histone deacetylase activity, metal ion binding, protein binding, zinc ion binding		
YMR076C	PDS5	Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis [Source:SGD;Acc:S000004681]	cell cycle, cell division, double-strand break repair, meiosis, mitosis, mitotic chromosome condensation, mitotic sister chromatid cohesion, synapsis	condensed nuclear chromosome, nucleus	binding, structural molecule activity		
YMR077C	VPS20	Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes [Source:SGD;Acc:S000004682]	intralumenal vesicle formation, late endosome to vacuole transport, protein transport, transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ESCRT III complex, cytoplasm, endosome, endosome membrane, membrane, vacuolar membrane, vacuole	protein binding		
YMR078C	CTF18	Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint [Source:SGD;Acc:S000004683]	DNA replication, cell cycle, double-strand break repair via homologous recombination, mitotic sister chromatid cohesion	Ctf18 RFC-like complex, mitochondrion, nuclear replication fork, nucleus	ATP binding, DNA binding, molecular_function, nucleoside-triphosphatase activity, nucleotide binding		
YMR079W	SEC14	Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; functionally homologous to mammalian PITPs [Source:SGD;Acc:S000004684]	Golgi to plasma membrane transport, Golgi to vacuole transport, ascospore formation, inositol phosphorylceramide metabolic process, mannosyl-inositol phosphorylceramide metabolic process, phosphatidylcholine metabolic process, phosphatidylinositol metabolic process, phospholipid transport, protein exit from endoplasmic reticulum, protein transport, transport	Golgi apparatus, Golgi membrane, cytoplasm, cytosol, intracellular, membrane	phosphatidylinositol transporter activity, transporter activity		
YMR080C	NAM7	ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance [Source:SGD;Acc:S000004685]	chromatin silencing at silent mating-type cassette, intracellular mRNA localization, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, protein ubiquitination, regulation of translational termination	cytoplasm, nucleus, polysome	ATP binding, ATP-dependent RNA helicase activity, DNA binding, RNA-dependent ATPase activity, helicase activity, hydrolase activity, metal ion binding, nucleic acid binding, nucleoside-triphosphatase activity, nucleotide binding, zinc ion binding		
YMR081C	ISF1	Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant [Source:SGD;Acc:S000004686]	aerobic respiration	cellular_component	molecular_function		
YMR082C	YMR082C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004687]					
YMR083W	ADH3	Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production [Source:SGD;Acc:S000004688]	NADH oxidation, amino acid catabolic process to alcohol via Ehrlich pathway, fermentation, metabolic process, oxidation-reduction process	mitochondrial matrix, mitochondrion, soluble fraction	alcohol dehydrogenase (NAD) activity, binding, catalytic activity, metal ion binding, oxidoreductase activity, zinc ion binding		
YMR084W	YMR084W	Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains [Source:SGD;Acc:S000004689]	biological_process, glutamine metabolic process, metabolic process	cellular_component	glutamine-fructose-6-phosphate transaminase (isomerizing) activity, molecular_function, transaminase activity, transferase activity		
YMR085W	YMR085W	Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains [Source:SGD;Acc:S000004690]	biological_process, carbohydrate metabolic process	cellular_component	molecular_function, sugar binding		
YMR086C-A	YMR086C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004691]					
YMR086W	YMR086W	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cell periphery; possible component of the eisosome; expression is repressed by cAMP [Source:SGD;Acc:S000004692]	biological_process	cytoplasm, ribosome	molecular_function		
YMR087W	YMR087W	Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain [Source:SGD;Acc:S000004693]	tRNA splicing, via endonucleolytic cleavage and ligation	cellular_component	hydrolase activity, phosphatase activity		
YMR088C	VBA1	Permease of basic amino acids in the vacuolar membrane [Source:SGD;Acc:S000004694]	amino acid transport, basic amino acid transport, transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	basic amino acid transmembrane transporter activity		
YMR089C	YTA12	Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes [Source:SGD;Acc:S000004695]	protein catabolic process, protein complex assembly, protein import into mitochondrial intermembrane space, proteolysis, signal peptide processing	cytoplasm, integral to membrane, m-AAA complex, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion	ATP binding, ATPase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, nucleoside-triphosphatase activity, nucleotide binding, peptidase activity, zinc ion binding		
YMR090W	YMR090W	Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability [Source:SGD;Acc:S000004696]	biological_process, metabolic process	cytoplasm	binding, catalytic activity, molecular_function		
YMR091C	NPL6	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length [Source:SGD;Acc:S000004697]	ATP-dependent chromatin remodeling, chromatin modification, chromatin remodeling, nucleosome disassembly, protein import into nucleus, response to DNA damage stimulus, transcription elongation from RNA polymerase II promoter	RSC complex, nucleus	DNA-dependent ATPase activity		
YMR092C	AIP1	Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats [Source:SGD;Acc:S000004698]	actin filament depolymerization, response to osmotic stress	actin cortical patch, cytoplasm, cytoskeleton, mating projection tip, nucleus	actin binding, protein binding		
YMR093W	UTP15	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000004699]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of transcription from RNA polymerase I promoter, rRNA processing, ribosome biogenesis	90S preribosome, nucleolus, nucleus, rDNA heterochromatin, ribonucleoprotein complex, small-subunit processome, t-UTP complex	protein binding, snoRNA binding		
YMR094W	CTF13	Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis [Source:SGD;Acc:S000004700]	kinetochore assembly, septin ring assembly	CBF3 complex, chromosome, centromeric region, condensed nuclear chromosome kinetochore, nucleus	DNA bending activity, DNA binding, centromeric DNA binding		
YMR095C	SNO1	Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase [Source:SGD;Acc:S000004701]	anti-apoptosis, glutamine metabolic process, pyridoxine biosynthetic process, pyridoxine metabolic process	cytoplasm	molecular_function, transferase activity		
YMR096W	SNZ1	Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins [Source:SGD;Acc:S000004702]	metabolic process, pyridoxal phosphate biosynthetic process, pyridoxine biosynthetic process, pyridoxine metabolic process	cellular_component	catalytic activity, protein binding		
YMR097C	MTG1	Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals [Source:SGD;Acc:S000004703]	mitochondrial translation	intracellular, membrane, mitochondrial inner membrane, mitochondrion	GTP binding, GTPase activity, nucleotide binding		
YMR098C	ATP25	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene [Source:SGD;Acc:S000004704]	mRNA stabilization, mitochondrial proton-transporting ATP synthase complex assembly	mitochondrial inner membrane, mitochondrion	molecular_function		
YMR099C	YMR099C	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000004705]	carbohydrate metabolic process, cellular carbohydrate metabolic process	cytoplasm, nucleus	carbohydrate binding, catalytic activity, glucose-6-phosphate 1-epimerase activity, isomerase activity		
YMR100W	MUB1	MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene [Source:SGD;Acc:S000004706]	protein monoubiquitination, regulation of cell budding	cellular_component, cytoplasm	metal ion binding, molecular_function, zinc ion binding		
YMR101C	SRT1	Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase [Source:SGD;Acc:S000004707]	protein glycosylation	lipid particle	dehydrodolichyl diphosphate synthase activity, prenyltransferase activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups		
YMR102C	YMR102C	Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene [Source:SGD;Acc:S000004708]	biological_process	cellular_component	molecular_function, protein binding		
YMR103C	YMR103C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004709]					
YMR104C	YPK2	Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK [Source:SGD;Acc:S000004710]	cellular cell wall organization, eisosome assembly, protein phosphorylation, regulation of cell shape	cytoplasm, nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YMR105C	PGM2	Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase [Source:SGD;Acc:S000004711]	UDP-glucose metabolic process, carbohydrate metabolic process, cellular calcium ion homeostasis, cellular cation homeostasis, galactose catabolic process, glucose 1-phosphate metabolic process, glucose 6-phosphate metabolic process, glucose metabolic process, glycogen biosynthetic process, trehalose biosynthetic process	cytoplasm	intramolecular transferase activity, phosphotransferases, isomerase activity, magnesium ion binding, metal ion binding, phosphoglucomutase activity		
YMR105W-A	YMR105W-A	Putative protein of unknown function [Source:SGD;Acc:S000028692]	biological_process	cellular_component	molecular_function		
YMR106C	YKU80	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair [Source:SGD;Acc:S000004712]	DNA recombination, DNA repair, chromatin assembly or disassembly, chromatin silencing, donor selection, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, protein localization to chromosome, response to DNA damage stimulus, telomere maintenance	Ku70:Ku80 complex, chromosome, telomeric region, nuclear chromatin, nuclear telomeric heterochromatin, nucleus	ATP binding, ATP-dependent DNA helicase activity, DNA binding, RNA binding, binding, damaged DNA binding, helicase activity, hydrolase activity, nucleotide binding, telomeric DNA binding		
YMR107W	SPG4	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources [Source:SGD;Acc:S000004713]	biological_process	cellular_component	molecular_function		
YMR108W	ILV2	Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control [Source:SGD;Acc:S000004714]	branched chain family amino acid biosynthetic process, cellular amino acid biosynthetic process	acetolactate synthase complex, mitochondrion	acetolactate synthase activity, catalytic activity, flavin adenine dinucleotide binding, magnesium ion binding, metal ion binding, thiamine pyrophosphate binding, transferase activity		
YMR109W	MYO5	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization [Source:SGD;Acc:S000004715]	actin cortical patch localization, bipolar cellular bud site selection, endocytosis, exocytosis, fungal-type cell wall organization, receptor-mediated endocytosis, response to osmotic stress, response to salt stress	actin cortical patch, cytoplasm, cytoskeleton, mating projection tip, myosin complex	ATP binding, actin binding, hydrolase activity, microfilament motor activity, motor activity, nucleotide binding, protein binding		
YMR110C	HFD1	Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome [Source:SGD;Acc:S000004716]	cellular aldehyde metabolic process, metabolic process, oxidation-reduction process	endosome, endosome membrane, integral to membrane, integral to mitochondrial outer membrane, lipid particle, membrane, mitochondrial outer membrane, mitochondrion	3-chloroallyl aldehyde dehydrogenase activity, aldehyde dehydrogenase [NAD(P)+] activity, oxidoreductase activity		
YMR111C	YMR111C	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene [Source:SGD;Acc:S000004717]	biological_process	nucleus	molecular_function		
YMR112C	MED11	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein [Source:SGD;Acc:S000004718]	regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus	structural molecule activity		
YMR113W	FOL3	Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis [Source:SGD;Acc:S000004719]	biosynthetic process, folic acid-containing compound biosynthetic process, one-carbon metabolic process	cytoplasm	ATP binding, dihydrofolate synthase activity, ligase activity, nucleotide binding, tetrahydrofolylpolyglutamate synthase activity		
YMR114C	YMR114C	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene [Source:SGD;Acc:S000004720]	biological_process	cytoplasm, nucleus, ribosome	molecular_function		
YMR115W	MGR3	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA [Source:SGD;Acc:S000004721]	misfolded or incompletely synthesized protein catabolic process	i-AAA complex, integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	misfolded protein binding		
YMR116C	ASC1	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation [Source:SGD;Acc:S000004722]	G-protein coupled receptor protein signaling pathway, glucose mediated signaling pathway, invasive growth in response to glucose limitation, negative regulation of translation	cytoplasm, cytosolic small ribosomal subunit	G-protein alpha-subunit binding, GDP-dissociation inhibitor activity, protein binding, signal transducer activity		
YMR117C	SPC24	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering [Source:SGD;Acc:S000004723]	cell cycle, cell division, chromosome segregation, microtubule nucleation, mitosis	Ndc80 complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, condensed nuclear chromosome, centromeric region, kinetochore, nucleus	structural constituent of cytoskeleton		
YMR118C	YMR118C	Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene [Source:SGD;Acc:S000004724]	biological_process, electron transport chain, transport, tricarboxylic acid cycle	cellular_component, integral to membrane, membrane, mitochondrial inner membrane, mitochondrion, plasma membrane succinate dehydrogenase complex	electron carrier activity, metal ion binding, molecular_function, oxidoreductase activity, acting on the CH-CH group of donors, quinone binding, succinate dehydrogenase activity		
YMR119W	ASI1	Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals [Source:SGD;Acc:S000004725]	ubiquitin-dependent protein catabolic process	endoplasmic reticulum membrane, integral to membrane, membrane, nuclear inner membrane, nuclear membrane, nucleus	ubiquitin-protein ligase activity		
YMR119W-A	YMR119W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004726]					
YMR120C	ADE17	Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine [Source:SGD;Acc:S000004727]	'de novo' IMP biosynthetic process, IMP biosynthetic process, purine nucleotide biosynthetic process	cytosol, plasma membrane enriched fraction	IMP cyclohydrolase activity, catalytic activity, hydrolase activity, phosphoribosylaminoimidazolecarboxamide formyltransferase activity, transferase activity		
YMR121C	RPL15B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA [Source:SGD;Acc:S000004728]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YMR122C	YMR122C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004729]					
YMR122W-A	YMR122W-A	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum [Source:SGD;Acc:S000007524]	biological_process	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YMR123W	PKR1	V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0) [Source:SGD;Acc:S000004730]	vacuolar proton-transporting V-type ATPase complex assembly	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YMR124W	YMR124W	Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization [Source:SGD;Acc:S000004731]	biological_process	cytoplasm	molecular_function		
YMR125W	STO1	Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 [Source:SGD;Acc:S000004732]	RNA metabolic process, RNA splicing, mRNA capping, mRNA processing, mRNA transport, nuclear mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, transport	commitment complex, cytoplasm, nuclear cap binding complex, nucleus, perinuclear region of cytoplasm	RNA binding, binding, mRNA binding, protein binding		
YMR126C	DLT1	Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA) [Source:SGD;Acc:S000004733]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YMR127C	SAS2	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family [Source:SGD;Acc:S000004734]	chromatin modification, chromatin silencing at telomere, histone acetylation, histone exchange	SAS acetyltransferase complex, cytoplasm, nuclear chromatin, nuclear chromosome, telomeric region, nucleus	acetyltransferase activity, acyltransferase activity, histone acetyltransferase activity, metal ion binding, transferase activity, transferase activity, transferring acyl groups other than amino-acyl groups		
YMR128W	ECM16	Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis [Source:SGD;Acc:S000004735]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, mitochondrion, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	ATP binding, ATP-dependent helicase activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YMR129W	POM152	Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase; [Source:SGD;Acc:S000004736]	NLS-bearing substrate import into nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear pore organization, protein export from nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	NDC1 complex, integral to membrane, membrane, mitochondrion, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YMR130W	YMR130W	Putative protein of unknown function; YMR130W is not an essential gene [Source:SGD;Acc:S000004737]	biological_process, metabolic process	cellular_component	catalytic activity, hydrolase activity, molecular_function, phosphoglycolate phosphatase activity		
YMR131C	RRB1	Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p [Source:SGD;Acc:S000004738]	rRNA processing, ribosome biogenesis	nucleolus, nucleus	molecular_function, protein binding		
YMR132C	JLP2	Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) [Source:SGD;Acc:S000004739]	biological_process	cytoplasm	molecular_function		
YMR133W	REC114	Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division [Source:SGD;Acc:S000004740]	DNA recombination, meiosis, meiotic DNA double-strand break formation, reciprocal meiotic recombination	chromosome, condensed nuclear chromosome, nucleus	molecular_function		
YMR134W	YMR134W	Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes [Source:SGD;Acc:S000004741]	cellular iron ion homeostasis, mitochondrion organization	cytoplasm, endoplasmic reticulum, integral to membrane, membrane, nuclear envelope	molecular_function		
YMR135C	GID8	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START [Source:SGD;Acc:S000004742]	cell cycle, negative regulation of gluconeogenesis, proteasomal ubiquitin-dependent protein catabolic process, traversing start control point of mitotic cell cycle	GID complex, cytoplasm, nucleus	molecular_function, protein binding		
YMR135W-A	YMR135W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004743]					
YMR136W	GAT2	Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine [Source:SGD;Acc:S000004744]	regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YMR137C	PSO2	Nuclease required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation [Source:SGD;Acc:S000004745]	DNA repair, double-strand break repair, response to DNA damage stimulus	nucleus	5'-3' exonuclease activity, damaged DNA binding, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity		
YMR138W	CIN4	GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog [Source:SGD;Acc:S000004746]	protein folding	cytoplasm	GTP binding, nucleotide binding		
YMR139W	RIM11	Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta [Source:SGD;Acc:S000004747]	ascospore formation, protein phosphorylation, proteolysis, response to stress	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YMR140W	SIP5	Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase [Source:SGD;Acc:S000004748]	cellular response to glucose starvation	cytoplasm	molecular_function		
YMR141C	YMR141C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004749]					
YMR141W-A	YMR141W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C [Source:SGD;Acc:S000028575]					
YMR142C	RPL13B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein [Source:SGD;Acc:S000004750]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YMR143W	RPS16A	Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins [Source:SGD;Acc:S000004751]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YMR144W	YMR144W	Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene [Source:SGD;Acc:S000004752]	biological_process	nucleus	molecular_function		
YMR145C	NDE1	Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain [Source:SGD;Acc:S000004753]	NADH oxidation, chronological cell aging, glucose catabolic process to ethanol, oxidation-reduction process	mitochondrial intermembrane space, mitochondrion	NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, flavin adenine dinucleotide binding, oxidoreductase activity		
YMR146C	TIF34	eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation [Source:SGD;Acc:S000004754]	translation, translational initiation	cytoplasm, eukaryotic translation initiation factor 3 complex, multi-eIF complex	protein binding, translation initiation factor activity		
YMR147W	YMR147W	Putative protein of unknown function [Source:SGD;Acc:S000004755]	biological_process	cellular_component	molecular_function		
YMR148W	OSW5	Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion [Source:SGD;Acc:S000004756]	biological_process	integral to membrane, membrane	molecular_function		
YMR149W	SWP1	Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum [Source:SGD;Acc:S000004757]	protein N-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity, transferase activity		
YMR150C	IMP1	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p [Source:SGD;Acc:S000004758]	protein processing involved in protein targeting to mitochondrion, proteolysis	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial inner membrane peptidase complex, mitochondrion	endopeptidase activity, hydrolase activity, peptidase activity, serine-type peptidase activity		
YMR151W	YIM2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 [Source:SGD;Acc:S000004759]					
YMR152W	YIM1	Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004760]	metabolic process, oxidation-reduction process, response to DNA damage stimulus	cytoplasm, integral to membrane, lipid particle, membrane, mitochondrion	binding, catalytic activity, molecular_function, oxidoreductase activity, zinc ion binding		
YMR153C-A	YMR153C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53 [Source:SGD;Acc:S000004761]					
YMR153W	NUP53	Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex [Source:SGD;Acc:S000004762]	NLS-bearing substrate import into nucleus, cell cycle, cell division, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, mitosis, nuclear pore organization, protein export from nucleus, protein import into nucleus, docking, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	karyopherin docking complex, membrane, nuclear membrane, nuclear pore, nucleus	structural molecule activity		
YMR154C	RIM13	Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB [Source:SGD;Acc:S000004763]	protein processing, proteolysis	cellular_component, intracellular	calcium-dependent cysteine-type endopeptidase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity		
YMR155W	YMR155W	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen [Source:SGD;Acc:S000004764]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YMR156C	TPP1	DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily [Source:SGD;Acc:S000004765]	DNA repair, response to DNA damage stimulus	cellular_component, nucleus	hydrolase activity, polynucleotide 3'-phosphatase activity		
YMR157C	AIM36	Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004766]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YMR158C-A	YMR158C-A	Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene [Source:SGD;Acc:S000007249]	biological_process	cellular_component	molecular_function		
YMR158W	MRPS8	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000004767]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YMR158W-B	YMR158W-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C [Source:SGD;Acc:S000004768]					
YMR159C	ATG16	Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy [Source:SGD;Acc:S000004769]	C-terminal protein lipidation, CVT pathway, autophagy, macroautophagy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein transport, transport	Atg12-Atg5-Atg16 complex, cytoplasmic membrane-bounded vesicle, cytoplasmic vesicle, membrane fraction, pre-autophagosomal structure, vacuole	Atg8 ligase activity, protein binding, bridging		
YMR160W	YMR160W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene [Source:SGD;Acc:S000004770]	biological_process	fungal-type vacuole membrane	molecular_function		
YMR161W	HLJ1	Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ [Source:SGD;Acc:S000004771]	ER-associated protein catabolic process, protein folding	endoplasmic reticulum, endoplasmic reticulum membrane	ATPase activator activity, heat shock protein binding, unfolded protein binding		
YMR162C	DNF3	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase [Source:SGD;Acc:S000004772]	ATP biosynthetic process, intracellular protein transport, metabolic process, phospholipid translocation, phospholipid transport	integral to membrane, membrane, trans-Golgi network transport vesicle	ATP binding, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, magnesium ion binding, nucleotide binding, phospholipid-translocating ATPase activity		
YMR163C	INP2	Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene [Source:SGD;Acc:S000004773]	peroxisome inheritance	cytoplasm, integral to membrane, integral to peroxisomal membrane, membrane, peroxisomal membrane, peroxisome	protein anchor, receptor activity		
YMR164C	MSS11	Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals [Source:SGD;Acc:S000004774]	positive regulation of transcription from RNA polymerase II promoter, pseudohyphal growth, starch catabolic process	cytoplasm, nucleus	protein binding		
YMR165C	PAH1	Mg<sup>2+</sup>-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and P<sub>i</sub>, responsible for de novo lipid synthesis; homologous to mammalian lipin 1 [Source:SGD;Acc:S000004775]	aerobic respiration, phospholipid biosynthetic process, plasmid maintenance	cytoplasm, membrane fraction	phosphatidate phosphatase activity		
YMR166C	YMR166C	Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene [Source:SGD;Acc:S000004776]	transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, transporter activity		
YMR167W	MLH1	Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer [Source:SGD;Acc:S000004777]	DNA repair, meiotic heteroduplex formation, meiotic mismatch repair, mismatch repair, reciprocal meiotic recombination, response to DNA damage stimulus	MutLalpha complex, MutLbeta complex, cytoplasm, mitochondrion, nucleus	ATP binding, ATPase activity, DNA insertion or deletion binding, dinucleotide insertion or deletion binding, double-stranded DNA binding, loop DNA binding, mismatched DNA binding, single-stranded DNA binding		
YMR168C	CEP3	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain [Source:SGD;Acc:S000004778]	mitotic cell cycle spindle assembly checkpoint, regulation of transcription, DNA-dependent, septin ring assembly	CBF3 complex, chromosome, centromeric region, condensed nuclear chromosome kinetochore, nucleus	DNA bending activity, DNA binding, centromeric DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YMR169C	ALD3	Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose [Source:SGD;Acc:S000004779]	beta-alanine biosynthetic process, metabolic process, oxidation-reduction process, polyamine catabolic process	cytoplasm	aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity, oxidoreductase activity		
YMR170C	ALD2	Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p [Source:SGD;Acc:S000004780]	beta-alanine biosynthetic process, cellular aldehyde metabolic process, metabolic process, oxidation-reduction process, polyamine catabolic process	cytoplasm	aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity, oxidoreductase activity		
YMR171C	EAR1	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p [Source:SGD;Acc:S000004781]	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, protein transport, transport	endosome, endosome membrane, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YMR172C-A	YMR172C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004782]					
YMR172W	HOT1	Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p [Source:SGD;Acc:S000004783]	hyperosmotic response, regulation of transcription from RNA polymerase II promoter	nuclear chromosome, nucleus			
YMR173W	DDR48	DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS [Source:SGD;Acc:S000004784]	DNA repair, response to stress	cytoplasm	ATPase activity, GTPase activity		
YMR173W-A	YMR173W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W [Source:SGD;Acc:S000004785]					
YMR174C	PAI3	Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact [Source:SGD;Acc:S000004786]	vacuolar protein catabolic process	cytoplasm	aspartic-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, peptidase inhibitor activity		
YMR175W	SIP18	Phospholipid-binding protein; expression is induced by osmotic stress [Source:SGD;Acc:S000004787]	biological_process	soluble fraction	phospholipid binding		
YMR175W-A	YMR175W-A	Putative protein of unknown function [Source:SGD;Acc:S000028848]	biological_process	cellular_component	molecular_function		
YMR176W	ECM5	Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks [Source:SGD;Acc:S000004788]	cellular cell wall organization, fungal-type cell wall organization	Snt2C complex, intracellular, nucleus	DNA binding, metal ion binding, molecular_function, protein binding, zinc ion binding		
YMR177W	MMT1	Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p [Source:SGD;Acc:S000004789]	cation transport, cellular iron ion homeostasis, ion transport, iron ion transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial membrane, mitochondrion	cation transmembrane transporter activity, molecular_function		
YMR178W	YMR178W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene [Source:SGD;Acc:S000004790]	Mo-molybdopterin cofactor biosynthetic process, biological_process	cytoplasm, nucleus	molecular_function		
YMR179W	SPT21	Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p [Source:SGD;Acc:S000004791]	chromatin silencing at rDNA, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, regulation of transcription from RNA polymerase II promoter	nucleus	molecular_function		
YMR180C	CTL1	RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm [Source:SGD;Acc:S000004792]	RNA processing, mRNA capping, mRNA processing	cytoplasm, mRNA cap methyltransferase complex, nucleus	hydrolase activity, polynucleotide 5'-phosphatase activity		
YMR181C	YMR181C	Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene [Source:SGD;Acc:S000004793]	biological_process	cellular_component	molecular_function		
YMR182C	RGM1	Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth [Source:SGD;Acc:S000004794]	negative regulation of transcription from RNA polymerase II promoter	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YMR182W-A	YMR182W-A	Putative protein of unknown function [Source:SGD;Acc:S000028693]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YMR183C	SSO2	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p [Source:SGD;Acc:S000004795]	Golgi to plasma membrane transport, ascospore-type prospore formation, intracellular protein transport, vesicle fusion, vesicle-mediated transport	cytoplasm, endoplasmic reticulum, integral to membrane, membrane, membrane fraction, plasma membrane, plasma membrane enriched fraction, prospore membrane	SNAP receptor activity, phosphatidic acid binding, protein binding		
YMR184W	ADD37	Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene [Source:SGD;Acc:S000004796]	ER-associated protein catabolic process	cytoplasm	molecular_function		
YMR185W	YMR185W	Putative protein of unknown function; conflicting evidence on whether null mutant is viable with elongated buds, or inviable [Source:SGD;Acc:S000004797]	biological_process	cellular_component	molecular_function		
YMR186W	HSC82	Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock [Source:SGD;Acc:S000004798]	'de novo' protein folding, proteasome assembly, protein folding, protein refolding, response to stress, telomere maintenance	cytoplasm, mitochondrion, plasma membrane enriched fraction	ATP binding, ATPase activity, coupled, nucleotide binding, unfolded protein binding		
YMR187C	YMR187C	Putative protein of unknown function; YMR187C is not an essential gene [Source:SGD;Acc:S000004799]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YMR188C	MRPS17	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000004800]	mitochondrial translation, sporulation resulting in formation of a cellular spore, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YMR189W	GCV2	P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm [Source:SGD;Acc:S000004801]	glycine decarboxylation via glycine cleavage system, glycine metabolic process, one-carbon metabolic process, oxidation-reduction process	glycine cleavage complex, mitochondrion	catalytic activity, glycine dehydrogenase (decarboxylating) activity, oxidoreductase activity, pyridoxal phosphate binding		
YMR190C	SGS1	Nucleolar DNA helicase of the RecQ family involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes [Source:SGD;Acc:S000004802]	DNA double-strand break processing, DNA duplex unwinding, DNA recombination, DNA repair, DNA replication, DNA unwinding involved in replication, cellular metabolic process, chromosome organization, double-strand break repair via homologous recombination, gene conversion at mating-type locus, DNA double-strand break processing, intra-S DNA damage checkpoint, meiotic DNA double-strand break processing, meiotic chromosome segregation, mitotic sister chromatid segregation, negative regulation of meiotic joint molecule formation, regulation of reciprocal meiotic recombination, replicative cell aging, response to DNA damage stimulus, telomere maintenance via recombination	RecQ helicase-Topo III complex, intracellular, nucleolus, nucleus	ATP binding, ATP-dependent 3'-5' DNA helicase activity, ATP-dependent DNA helicase activity, ATP-dependent helicase activity, catalytic activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YMR191W	SPG5	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources [Source:SGD;Acc:S000004803]	biological_process	cellular_component	molecular_function		
YMR192W	GYL1	Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p [Source:SGD;Acc:S000004804]	ER to Golgi vesicle-mediated transport, regulation of Rab GTPase activity, regulation of exocytosis	Golgi-associated vesicle, cellular bud, cellular bud neck, cellular bud tip, cytoplasm, incipient cellular bud site, intracellular, mitochondrion, plasma membrane	Rab GTPase activator activity		
YMR193C-A	YMR193C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004805]					
YMR193W	MRPL24	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004806]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YMR194C-A	YMR194C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007250]					
YMR194C-B	CMC4	Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs [Source:SGD;Acc:S000028514]	biological_process	mitochondrial intermembrane space	molecular_function		
YMR194W	RPL36A	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA [Source:SGD;Acc:S000004807]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YMR195W	ICY1	Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation [Source:SGD;Acc:S000004808]	biological_process	fungal-type vacuole membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YMR196W	YMR196W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene [Source:SGD;Acc:S000004809]	biological_process	cytoplasm	catalytic activity, molecular_function		
YMR197C	VTI1	Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways [Source:SGD;Acc:S000004810]	Golgi to vacuole transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, late endosome to vacuole transport, protein transport, transport, vesicle fusion, vesicle-mediated transport	Golgi apparatus, Golgi membrane, SNARE complex, integral to Golgi membrane, integral to membrane, late endosome membrane, membrane	SNAP receptor activity, protein binding		
YMR198W	CIK1	Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p [Source:SGD;Acc:S000004811]	establishment of mitotic spindle orientation, karyogamy involved in conjugation with cellular fusion, meiosis, mitotic sister chromatid segregation, mitotic spindle organization in nucleus, nuclear migration involved in conjugation with cellular fusion	cytoplasm, cytoplasmic microtubule, cytoskeleton, kinesin complex, microtubule, nucleus, spindle, spindle pole body	microtubule motor activity, minus-end-directed microtubule motor activity, protein heterodimerization activity		
YMR199W	CLN1	G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) [Source:SGD;Acc:S000004812]	cell cycle, cell division, regulation of cyclin-dependent protein kinase activity	cytoplasm, nucleus	cyclin-dependent protein kinase regulator activity		
YMR200W	ROT1	Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations [Source:SGD;Acc:S000004813]	'de novo' protein folding, budding cell apical bud growth, cell cycle cytokinesis, establishment or maintenance of actin cytoskeleton polarity, fungal-type cell wall organization, protein folding	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane			
YMR201C	RAD14	Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein [Source:SGD;Acc:S000004814]	DNA repair, nucleotide-excision repair, nucleotide-excision repair, DNA damage recognition, response to DNA damage stimulus	nucleotide-excision repair factor 1 complex, nucleus	DNA binding, damaged DNA binding, metal ion binding, nucleotide binding, zinc ion binding		
YMR202W	ERG2	C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis [Source:SGD;Acc:S000004815]	ergosterol biosynthetic process, lipid biosynthetic process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	C-8 sterol isomerase activity, isomerase activity		
YMR203W	TOM40	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore [Source:SGD;Acc:S000004816]	anion transport, intracellular protein transport, ion transport, protein import into mitochondrial matrix, protein transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion, pore complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity, porin activity, protein channel activity, voltage-gated anion channel activity		
YMR204C	INP1	Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane [Source:SGD;Acc:S000004817]	peroxisome inheritance	extrinsic to intraperoxisomal membrane, membrane, peroxisomal membrane, peroxisome	molecular_function		
YMR205C	PFK2	Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes [Source:SGD;Acc:S000004818]	glycolysis	6-phosphofructokinase complex, cytoplasm, mitochondrion	6-phosphofructokinase activity, ATP binding, catalytic activity, kinase activity, nucleotide binding, transferase activity		
YMR206W	YMR206W	Putative protein of unknown function; YMR206W is not an essential gene [Source:SGD;Acc:S000004819]	biological_process	cellular_component	molecular_function		
YMR207C	HFA1	Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis [Source:SGD;Acc:S000004820]	fatty acid biosynthetic process, lipid biosynthetic process, metabolic process	mitochondrion	ATP binding, acetyl-CoA carboxylase activity, biotin binding, biotin carboxylase activity, catalytic activity, ligase activity, nucleotide binding		
YMR208W	ERG12	Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate [Source:SGD;Acc:S000004821]	ergosterol biosynthetic process, farnesyl diphosphate biosynthetic process, mevalonate pathway, isopentenyl diphosphate biosynthetic process, mevalonate pathway, isoprenoid biosynthetic process, lipid biosynthetic process, metabolic process, phosphorylation, steroid biosynthetic process, sterol biosynthetic process	cytoplasm, cytosol	ATP binding, kinase activity, mevalonate kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YMR209C	YMR209C	Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene [Source:SGD;Acc:S000004822]	biological_process	cellular_component, integral to membrane, membrane	S-adenosylmethionine-dependent methyltransferase activity		
YMR210W	YMR210W	Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification [Source:SGD;Acc:S000004823]	medium-chain fatty acid biosynthetic process	cellular_component	acyltransferase activity, carboxylesterase activity, hydrolase activity		
YMR211W	DML1	Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family [Source:SGD;Acc:S000004824]	mitochondrial genome maintenance, plasmid maintenance, protein polymerization	cytoplasm, mitochondrion, protein complex	molecular_function		
YMR212C	EFR3	Protein required for Stt4-containing phosphoinositide kinase patch assembly at the plasma membrane; exhibits synthetic lethal genetic interactions with PHO85; has sequence similarity to the Drosophila rolling blackout (RBO) gene [Source:SGD;Acc:S000004825]	establishment of protein localization in plasma membrane	mitochondrion, plasma membrane	molecular_function		
YMR213W	CEF1	Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p [Source:SGD;Acc:S000004826]	RNA splicing, cell cycle, mRNA processing, nuclear mRNA splicing, via spliceosome	Prp19 complex, U2-type catalytic step 1 spliceosome, cytoplasm, nucleus, spliceosomal complex	DNA binding, first spliceosomal transesterification activity, protein binding		
YMR214W	SCJ1	One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins [Source:SGD;Acc:S000004827]	ER-associated protein catabolic process, protein folding, protein folding in endoplasmic reticulum, protein transport, response to unfolded protein, transport	endoplasmic reticulum, endoplasmic reticulum lumen	chaperone binding, heat shock protein binding, metal ion binding, unfolded protein binding		
YMR215W	GAS3	Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall [Source:SGD;Acc:S000004828]	biological_process, carbohydrate metabolic process, cellular cell wall organization	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane, membrane fraction, plasma membrane enriched fraction	1,3-beta-glucanosyltransferase activity, catalytic activity, cation binding, transferase activity		
YMR216C	SKY1	SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 [Source:SGD;Acc:S000004829]	cellular cation homeostasis, cellular ion homeostasis, mRNA splice site selection, positive regulation of protein import into nucleus, protein phosphorylation, regulation of cell size, response to drug	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YMR217W	GUA1	GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation [Source:SGD;Acc:S000004830]	GMP biosynthetic process, GMP metabolic process, biosynthetic process, glutamine metabolic process, purine nucleotide biosynthetic process	cellular_component, cytoplasm	ATP binding, GMP synthase (glutamine-hydrolyzing) activity, catalytic activity, ligase activity, nucleotide binding		
YMR218C	TRS130	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1 [Source:SGD;Acc:S000004831]	early endosome to Golgi transport, intra-Golgi vesicle-mediated transport, regulation of Rab GTPase activity, transport	Golgi apparatus, TRAPP complex, early endosome, trans-Golgi network	Rab guanyl-nucleotide exchange factor activity		
YMR219W	ESC1	Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p [Source:SGD;Acc:S000004832]	chromatin silencing at telomere	nuclear periphery, nucleus	molecular_function, protein binding		
YMR220W	ERG8	Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate [Source:SGD;Acc:S000004833]	ergosterol biosynthetic process, farnesyl diphosphate biosynthetic process, mevalonate pathway, isopentenyl diphosphate biosynthetic process, mevalonate pathway, isoprenoid biosynthetic process, lipid biosynthetic process, organic acid phosphorylation, phosphorylation, steroid biosynthetic process, sterol biosynthetic process	cytoplasm, nucleus	ATP binding, kinase activity, nucleotide binding, phosphomevalonate kinase activity, transferase activity		
YMR221C	YMR221C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy [Source:SGD;Acc:S000004834]	biological_process, transport	fungal-type vacuole, integral to membrane, membrane, mitochondrion, vacuolar membrane, vacuole	molecular_function		
YMR222C	FSH2	Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2 [Source:SGD;Acc:S000004835]	biological_process	cytoplasm	carboxylesterase activity, hydrolase activity, molecular_function		
YMR223W	UBP8	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B [Source:SGD;Acc:S000004836]	histone deubiquitination, ubiquitin-dependent protein catabolic process	DUBm complex, SAGA complex, SLIK (SAGA-like) complex, nucleus	cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, protein complex scaffold, ubiquitin thiolesterase activity, ubiquitin-specific protease activity, zinc ion binding		
YMR224C	MRE11	Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved [Source:SGD;Acc:S000004837]	DNA metabolic process, DNA repair, ascospore formation, base-excision repair, double-strand break repair, double-strand break repair via break-induced replication, double-strand break repair via nonhomologous end joining, meiosis, meiotic DNA double-strand break formation, meiotic DNA double-strand break processing, regulation of transcription during meiosis, response to DNA damage stimulus	Mre11 complex, mitochondrion, nucleus	3'-5' exonuclease activity, G-quadruplex DNA binding, adenylate kinase activity, double-stranded telomeric DNA binding, endodeoxyribonuclease activity, endonuclease activity, exonuclease activity, hydrolase activity, manganese ion binding, nuclease activity, protein complex scaffold, single-stranded telomeric DNA binding, telomeric DNA binding		
YMR225C	MRPL44	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004838]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YMR226C	YMR226C	NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000004839]	metabolic process, oxidation-reduction process	cytoplasm, nucleus, ribosome	binding, carbonyl reductase (NADPH) activity, catalytic activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor		
YMR227C	TAF7	TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation [Source:SGD;Acc:S000004840]	RNA polymerase II transcriptional preinitiation complex assembly, transcription initiation from RNA polymerase II promoter	nucleus, transcription factor TFIID complex			
YMR228W	MTF1	Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p [Source:SGD;Acc:S000004841]	rRNA modification, transcription initiation from mitochondrial promoter	mitochondrial DNA-directed RNA polymerase complex, mitochondrial intermembrane space, mitochondrial matrix, mitochondrion	DNA binding, S-adenosylmethionine-dependent methyltransferase activity, mitochondrial RNA polymerase binding promoter specificity activity, rRNA (adenine-N6,N6-)-dimethyltransferase activity, rRNA methyltransferase activity		
YMR229C	RRP5	RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome [Source:SGD;Acc:S000004842]	RNA processing, endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, intracellular, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	RNA binding, binding, poly(U) RNA binding		
YMR230W	RPS10B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10 [Source:SGD;Acc:S000004843]	rRNA export from nucleus, translation	cytoplasm, cytosolic small ribosomal subunit, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YMR230W-A	YMR230W-A	Putative protein of unknown function [Source:SGD;Acc:S000028576]	biological_process	cellular_component	molecular_function		
YMR231W	PEP5	Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p [Source:SGD;Acc:S000004844]	Golgi to endosome transport, late endosome to vacuole transport, protein transport, regulation of SNARE complex assembly, regulation of vacuole fusion, non-autophagic, transport, vacuole fusion, non-autophagic, vesicle docking involved in exocytosis	CORVET complex, HOPS complex, fungal-type vacuole membrane, membrane, vacuolar membrane, vacuole	metal ion binding, phosphatidylinositol binding, protein binding, zinc ion binding		
YMR232W	FUS2	Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating [Source:SGD;Acc:S000004845]	cytogamy, karyogamy involved in conjugation with cellular fusion, regulation of Rho protein signal transduction, regulation of termination of mating projection growth	cell tip, cytoplasm, intracellular, mating projection tip, mitochondrion, nucleus	Rho guanyl-nucleotide exchange factor activity, molecular_function		
YMR233W	TRI1	Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus [Source:SGD;Acc:S000004846]	biological_process	cytoplasm, nucleolus, nucleus	molecular_function, protein binding		
YMR234W	RNH1	Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) [Source:SGD;Acc:S000004847]	RNA catabolic process, fungal-type cell wall organization	intracellular, nucleus	endonuclease activity, hydrolase activity, magnesium ion binding, metal ion binding, nuclease activity, nucleic acid binding, ribonuclease H activity		
YMR235C	RNA1	GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport [Source:SGD;Acc:S000004848]	RNA import into nucleus, chromatin silencing at telomere, protein import into nucleus, rRNA export from nucleus, rRNA metabolic process, ribosomal subunit export from nucleus, tRNA metabolic process	cytoplasm, cytosol, nucleus	GTPase activator activity, Ran GTPase activator activity		
YMR236W	TAF9	Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3 [Source:SGD;Acc:S000004849]	RNA polymerase II transcriptional preinitiation complex assembly, chromatin modification, histone acetylation, transcription initiation, DNA-dependent	SAGA complex, SLIK (SAGA-like) complex, nucleus, transcription factor TFIID complex	DNA binding, chromatin binding, protein complex scaffold		
YMR237W	BCH1	Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes [Source:SGD;Acc:S000004850]	Golgi to plasma membrane transport, fungal-type cell wall chitin biosynthetic process, protein transport, transport	Golgi apparatus, clathrin-coated vesicle, exomer complex, membrane, ribosome	binding, molecular_function		
YMR238W	DFG5	Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p [Source:SGD;Acc:S000004851]	budding cell bud growth, carbohydrate catabolic process, cellular cell wall organization, fungal-type cell wall biogenesis, metabolic process, pseudohyphal growth	anchored to membrane, anchored to plasma membrane, membrane, plasma membrane	catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, mannan endo-1,6-alpha-mannosidase activity, mannosidase activity		
YMR239C	RNT1	RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; involved in polyadenylation-independent transcription termination [Source:SGD;Acc:S000004852]	RNA processing, U1 snRNA 3'-end processing, U4 snRNA 3'-end processing, U5 snRNA 3'-end processing, chromatin organization, rRNA processing, rRNA transcription, termination of RNA polymerase II transcription, exosome-dependent	intracellular, nucleolus, nucleoplasm	RNA binding, double-stranded RNA binding, endonuclease activity, hydrolase activity, nuclease activity, ribonuclease III activity		
YMR240C	CUS1	Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p [Source:SGD;Acc:S000004853]	mRNA processing, nuclear mRNA splicing, via spliceosome, spliceosome assembly	U2 snRNP, U2-type prespliceosome, nucleus	RNA binding, molecular_function		
YMR241W	YHM2	Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome [Source:SGD;Acc:S000004854]	alpha-ketoglutarate transport, mitochondrial citrate transport, mitochondrial genome maintenance, transmembrane transport, transport, tricarboxylic acid transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrion	DNA binding, binding, tricarboxylate secondary active transmembrane transporter activity		
YMR242C	RPL20A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein [Source:SGD;Acc:S000004855]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YMR242W-A	YMR242W-A	Putative protein of unknown function [Source:SGD;Acc:S000028694]	biological_process	cellular_component	molecular_function		
YMR243C	ZRC1	Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm [Source:SGD;Acc:S000004856]	cation transport, cellular zinc ion homeostasis, cobalt ion transport, glutathione metabolic process, ion transport, response to cadmium ion, transmembrane transport, transport, zinc ion transport	fungal-type vacuole, integral to membrane, membrane, mitochondrial membrane, mitochondrion	cation transmembrane transporter activity, inorganic cation transmembrane transporter activity, zinc ion transmembrane transporter activity		
YMR244C-A	YMR244C-A	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene [Source:SGD;Acc:S000004857]	biological_process	cytoplasm, mitochondrion, nucleus	cytochrome-c oxidase activity, molecular_function		
YMR244W	YMR244W	Putative protein of unknown function [Source:SGD;Acc:S000004858]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YMR245W	YMR245W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004859]					
YMR246W	FAA4	Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles [Source:SGD;Acc:S000004860]	fatty acid metabolic process, lipid metabolic process, long-chain fatty acid transport, long-chain fatty-acyl-CoA metabolic process, metabolic process	cytoplasm, lipid particle	ATP binding, catalytic activity, ligase activity, long-chain fatty acid-CoA ligase activity, nucleotide binding		
YMR247C	RKR1	RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse listerin [Source:SGD;Acc:S000004861]	chromatin modification, chromatin silencing at telomere, protein ubiquitination, ubiquitin-dependent protein catabolic process	nucleus, ribosome	binding, metal ion binding, protein binding, ribosome binding, ubiquitin-protein ligase activity, zinc ion binding		
YMR247W-A	YMR247W-A	Putative protein of unknown function [Source:SGD;Acc:S000028849]	biological_process	cellular_component	molecular_function		
YMR250W	GAD1	Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress [Source:SGD;Acc:S000004862]	carboxylic acid metabolic process, cellular response to oxidative stress, glutamate catabolic process, glutamate metabolic process	cytoplasm	calmodulin binding, carboxy-lyase activity, catalytic activity, glutamate decarboxylase activity, lyase activity, pyridoxal phosphate binding		
YMR251W	GTO3	Omega class glutathione transferase; putative cytosolic localization [Source:SGD;Acc:S000004863]	glutathione metabolic process	cytoplasm	glutathione transferase activity, transferase activity		
YMR251W-A	HOR7	Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor [Source:SGD;Acc:S000004864]	response to stress	endoplasmic reticulum, fungal-type cell wall, membrane fraction, plasma membrane	molecular_function		
YMR252C	YMR252C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene [Source:SGD;Acc:S000004865]	biological_process	mitochondrion	molecular_function		
YMR253C	YMR253C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene [Source:SGD;Acc:S000004866]	biological_process	cytoplasm, integral to membrane, membrane	molecular_function		
YMR254C	YMR254C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004867]					
YMR255W	GFD1	Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation [Source:SGD;Acc:S000004868]	mRNA export from nucleus, mRNA transport, protein transport, transmembrane transport, transport	cytoplasm, membrane, nuclear membrane, nuclear pore, nucleus	molecular_function		
YMR256C	COX7	Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain [Source:SGD;Acc:S000004869]	mitochondrial electron transport, cytochrome c to oxygen, oxidation-reduction process	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion	cytochrome-c oxidase activity, oxidoreductase activity		
YMR257C	PET111	Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane [Source:SGD;Acc:S000004870]	positive regulation of mitochondrial translation, regulation of translation	mitochondrial inner membrane, mitochondrial matrix, mitochondrion	translation regulator activity		
YMR258C	YMR258C	Protein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene [Source:SGD;Acc:S000004871]	biological_process	cytoplasm, nucleus	molecular_function		
YMR259C	YMR259C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene [Source:SGD;Acc:S000004872]	biological_process	cytoplasm	binding, molecular_function		
YMR260C	TIF11	Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 [Source:SGD;Acc:S000004873]	translation, translational initiation	ribosome	RNA binding, double-stranded RNA binding, translation initiation factor activity		
YMR261C	TPS3	Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway [Source:SGD;Acc:S000004874]	response to stress, trehalose biosynthetic process	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming), cytoplasm	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, catalytic activity, enzyme regulator activity, trehalose-phosphatase activity		
YMR262W	YMR262W	Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene [Source:SGD;Acc:S000004875]	biological_process	cellular_component	endodeoxyribonuclease activity, producing 5'-phosphomonoesters, hydrolase activity, molecular_function, nuclease activity		
YMR263W	SAP30	Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance [Source:SGD;Acc:S000004876]	chromatin modification, histone deacetylation, negative regulation of chromatin silencing at rDNA, negative regulation of chromatin silencing at silent mating-type cassette, negative regulation of chromatin silencing at telomere, negative regulation of transcription from RNA polymerase I promoter	Rpd3L complex, Rpd3L-Expanded complex, histone deacetylase complex, nucleus	histone deacetylase activity		
YMR264W	CUE1	Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination [Source:SGD;Acc:S000004877]	ER-associated protein catabolic process, establishment of protein localization	Doa10p ubiquitin ligase complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion	protein binding, ubiquitin binding		
YMR265C	YMR265C	Putative protein of unknown function [Source:SGD;Acc:S000004878]	biological_process	cellular_component	molecular_function		
YMR266W	RSN1	Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane [Source:SGD;Acc:S000004879]	Golgi to plasma membrane transport	integral to membrane, membrane	molecular_function		
YMR267W	PPA2	Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate [Source:SGD;Acc:S000004880]	aerobic respiration, phosphate metabolic process	cytoplasm, mitochondrion	hydrolase activity, inorganic diphosphatase activity, magnesium ion binding, metal ion binding		
YMR268C	PRP24	Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling [Source:SGD;Acc:S000004881]	RNA splicing, assembly of spliceosomal tri-snRNP, mRNA processing, spliceosome assembly	U6 snRNP, nucleus	RNA binding, U6 snRNA binding, nucleic acid binding, nucleotide binding, snRNA binding		
YMR269W	TMA23	Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes [Source:SGD;Acc:S000004882]	ribosomal small subunit biogenesis, ribosome biogenesis	nucleolus, nucleus, ribosome	molecular_function		
YMR270C	RRN9	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I [Source:SGD;Acc:S000004883]	transcription from RNA polymerase I promoter, transcription of nuclear rRNA large RNA polymerase I transcript	RNA polymerase I upstream activating factor complex, nucleolus, nucleus	rDNA binding		
YMR271C	URA10	Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5 [Source:SGD;Acc:S000004884]	'de novo' pyrimidine base biosynthetic process, nucleoside metabolic process, pyrimidine nucleotide biosynthetic process, pyrimidine ribonucleoside biosynthetic process	cytoplasm	orotate phosphoribosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YMR272C	SCS7	Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth [Source:SGD;Acc:S000004885]	electron transport chain, fatty acid biosynthetic process, inositol phosphorylceramide metabolic process, lipid biosynthetic process, oxidation-reduction process, sphingolipid metabolic process, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	fatty acid alpha-hydroxylase activity, heme binding, iron ion binding, metal ion binding, oxidoreductase activity		
YMR272W-A	YMR272W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SCS7/YMR272C [Source:SGD;Acc:S000028695]					
YMR272W-B	YMR272W-B	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028696]	biological_process	cellular_component	molecular_function		
YMR273C	ZDS1	Protein with a role in regulating Swe1p-dependent polarized growth; interacts with silencing proteins at the telomere; has a role in Bcy1p localization; implicated in mRNA nuclear export; involved in mitotic exit through Cdc14p regulation [Source:SGD;Acc:S000004886]	cell aging, cell shape checkpoint, cellular cell wall organization, chromatin silencing, establishment of cell polarity, mRNA export from nucleus, mRNA transport, regulation of protein localization, transport	cellular bud tip, cytoplasm, incipient cellular bud site, nuclear pore	protein phosphatase type 2A regulator activity		
YMR274C	RCE1	Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone [Source:SGD;Acc:S000004887]	CAAX-box protein processing, peptide pheromone maturation, protein processing, response to pheromone	endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	hydrolase activity, metalloendopeptidase activity		
YMR275C	BUL1	Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases [Source:SGD;Acc:S000004888]	mitochondrion inheritance, protein monoubiquitination, protein polyubiquitination	cytoplasm, plasma membrane, ubiquitin ligase complex	ubiquitin binding		
YMR276W	DSK2	Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome [Source:SGD;Acc:S000004889]	ER-associated protein catabolic process, spindle pole body duplication in nuclear envelope	nucleus	protein binding, protein binding, bridging		
YMR277W	FCP1	Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) [Source:SGD;Acc:S000004890]	protein dephosphorylation, regulation of transcription from RNA polymerase II promoter	intracellular, nucleus	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding		
YMR278W	PGM3	Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential [Source:SGD;Acc:S000004891]	biological_process, carbohydrate metabolic process, glucose metabolic process	cytoplasm, nucleus	intramolecular transferase activity, phosphotransferases, isomerase activity, magnesium ion binding, metal ion binding, phosphoglucomutase activity		
YMR279C	YMR279C	Putative paralog of ATR1, but not required for boron tolerance; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene [Source:SGD;Acc:S000004892]	biological_process, transmembrane transport, transport	cellular_component, integral to membrane, membrane	molecular_function		
YMR280C	CAT8	Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements [Source:SGD;Acc:S000004893]	carbohydrate metabolic process, positive regulation of gluconeogenesis, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YMR281W	GPI12	ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp [Source:SGD;Acc:S000004894]	GPI anchor biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	N-acetylglucosaminylphosphatidylinositol deacetylase activity, hydrolase activity		
YMR282C	AEP2	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader [Source:SGD;Acc:S000004895]	mitochondrial translational initiation	mitochondrion	molecular_function		
YMR283C	RIT1	2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA [Source:SGD;Acc:S000004896]	charged-tRNA amino acid modification, tRNA processing	cytoplasm	transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring pentosyl groups		
YMR284W	YKU70	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair [Source:SGD;Acc:S000004897]	DNA recombination, DNA repair, chromatin assembly or disassembly, chromatin silencing, chromatin silencing at silent mating-type cassette, double-strand break repair via break-induced replication, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, response to DNA damage stimulus, telomere maintenance	DNA-dependent protein kinase-DNA ligase 4 complex, Ku70:Ku80 complex, chromosome, telomeric region, nuclear chromatin, nuclear envelope, nuclear telomeric heterochromatin, nucleus	ATP binding, ATP-dependent DNA helicase activity, DNA binding, RNA binding, binding, damaged DNA binding, helicase activity, hydrolase activity, nucleotide binding		
YMR285C	NGL2	Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p [Source:SGD;Acc:S000004898]	rRNA processing	cytoplasm, intracellular, nucleus	RNA binding, endoribonuclease activity, exonuclease activity, hydrolase activity, nuclease activity		
YMR286W	MRPL33	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004899]	mitochondrial translation, translation	intracellular, large ribosomal subunit, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YMR287C	DSS1	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs [Source:SGD;Acc:S000004900]	RNA catabolic process	mitochondrial matrix, mitochondrion	RNA binding, exonuclease activity, exoribonuclease II activity, hydrolase activity, nuclease activity, ribonuclease activity		
YMR288W	HSH155	U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 [Source:SGD;Acc:S000004901]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome, spliceosome assembly	U2 snRNP, U2-type prespliceosome, nucleus, spliceosomal complex	binding, mRNA binding		
YMR289W	ABZ2	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis [Source:SGD;Acc:S000004902]	folic acid biosynthetic process, metabolic process	cytoplasm	4-amino-4-deoxychorismate lyase activity, catalytic activity, lyase activity		
YMR290C	HAS1	ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles [Source:SGD;Acc:S000004903]	rRNA processing, ribosome biogenesis	90S preribosome, nuclear envelope, nucleolus, nucleus, preribosome, large subunit precursor	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, RNA-dependent ATPase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YMR290W-A	YMR290W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase [Source:SGD;Acc:S000004904]					
YMR291W	YMR291W	Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR291W is not an essential gene [Source:SGD;Acc:S000004905]	biological_process, protein phosphorylation	cytoplasm, nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YMR292W	GOT1	Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition [Source:SGD;Acc:S000004906]	ER to Golgi vesicle-mediated transport, Golgi to endosome transport, protein transport, transport, vesicle-mediated transport	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, integral to membrane, membrane	molecular_function		
YMR293C	HER2	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase [Source:SGD;Acc:S000004907]	endoplasmic reticulum organization, glutaminyl-tRNAGln biosynthesis via transamidation, translation	glutamyl-tRNA(Gln) amidotransferase complex, mitochondrion	ATP binding, carbon-nitrogen ligase activity, with glutamine as amido-N-donor, glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, ligase activity, nucleotide binding		
YMR294W	JNM1	Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B [Source:SGD;Acc:S000004908]	establishment of mitotic spindle orientation, microtubule-based process, nuclear migration	astral microtubule, cell cortex, cytoplasm, cytoskeleton, dynactin complex, dynein complex, microtubule, spindle pole body	motor activity, structural constituent of cytoskeleton		
YMR294W-A	YMR294W-A	Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents [Source:SGD;Acc:S000004909]					
YMR295C	YMR295C	Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene [Source:SGD;Acc:S000004910]	biological_process	cellular bud, mating projection tip, ribosome	molecular_function		
YMR296C	LCB1	Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine [Source:SGD;Acc:S000004911]	biosynthetic process, sphingolipid biosynthetic process	SPOTS complex, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, membrane fraction, microsome, serine C-palmitoyltransferase complex	acyltransferase activity, catalytic activity, pyridoxal phosphate binding, serine C-palmitoyltransferase activity, transferase activity, transferase activity, transferring nitrogenous groups		
YMR297W	PRC1	Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family [Source:SGD;Acc:S000004912]	phytochelatin biosynthetic process, proteolysis, vacuolar protein catabolic process	cytoplasm, endoplasmic reticulum, fungal-type vacuole, fungal-type vacuole lumen, vacuole	carboxypeptidase activity, hydrolase activity, peptidase activity, serine-type carboxypeptidase activity		
YMR298W	LIP1	Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis [Source:SGD;Acc:S000004913]	ceramide biosynthetic process, lipid biosynthetic process, lipid metabolic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear envelope	sphingosine N-acyltransferase activity		
YMR299C	DYN3	Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration [Source:SGD;Acc:S000004914]	nuclear migration along microtubule	cytoplasm, cytoplasmic dynein complex, cytoplasmic microtubule, cytoskeleton, dynein complex, microtubule	motor activity		
YMR300C	ADE4	Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway [Source:SGD;Acc:S000004915]	'de novo' IMP biosynthetic process, glutamine metabolic process, metabolic process, nucleoside metabolic process, purine base biosynthetic process, purine nucleotide biosynthetic process	cytoplasm	amidophosphoribosyltransferase activity, metal ion binding, transferase activity, transferase activity, transferring glycosyl groups		
YMR301C	ATM1	Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol [Source:SGD;Acc:S000004916]	cellular iron ion homeostasis, ion transport, iron ion transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YMR302C	YME2	Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases [Source:SGD;Acc:S000004917]	mRNA processing, mitochondrial genome maintenance	integral to membrane, integral to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion	RNA binding, molecular_function, nucleic acid binding, nucleotide binding		
YMR303C	ADH2	Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 [Source:SGD;Acc:S000004918]	NADH oxidation, amino acid catabolic process to alcohol via Ehrlich pathway, ethanol metabolic process, fermentation, metabolic process, oxidation-reduction process	cytoplasm	alcohol dehydrogenase (NAD) activity, binding, catalytic activity, metal ion binding, oxidoreductase activity, zinc ion binding		
YMR304C-A	YMR304C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10 [Source:SGD;Acc:S000004919]					
YMR304W	UBP15	Ubiquitin-specific protease that may play a role in ubiquitin precursor processing [Source:SGD;Acc:S000004920]	protein deubiquitination, ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YMR305C	SCW10	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p [Source:SGD;Acc:S000004921]	carbohydrate metabolic process, cellular cell wall organization, conjugation with cellular fusion, metabolic process	cell wall, cytoplasm, endoplasmic reticulum, extracellular region, fungal-type cell wall	catalytic activity, cation binding, glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds		
YMR306C-A	YMR306C-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004922]					
YMR306W	FKS3	Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004923]	1,3-beta-D-glucan biosynthetic process, ascospore wall assembly, cellular cell wall organization, regulation of cell shape, sporulation resulting in formation of a cellular spore	1,3-beta-D-glucan synthase complex, integral to membrane, membrane, mitochondrion	1,3-beta-D-glucan synthase activity, transferase activity, transferase activity, transferring glycosyl groups		
YMR307C-A	YMR307C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GAS1/YMR307W [Source:SGD;Acc:S000028578]					
YMR307W	GAS1	Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery [Source:SGD;Acc:S000004924]	carbohydrate metabolic process, cellular cell wall organization, chromatin silencing, filamentous growth, fungal-type cell wall organization	ER to Golgi transport vesicle, anchored to membrane, cell wall, cellular bud scar, extracellular region, fungal-type cell wall, membrane, membrane raft, mitochondrion, nuclear periphery, plasma membrane, plasma membrane enriched fraction, primary cell septum	1,3-beta-glucanosyltransferase activity, catalytic activity, cation binding, transferase activity		
YMR308C	PSE1	Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p [Source:SGD;Acc:S000004925]	mRNA export from nucleus, protein import into nucleus, protein transport, transport	cytoplasm, nucleus	binding, protein transporter activity		
YMR309C	NIP1	eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection [Source:SGD;Acc:S000004926]	translation, translational initiation	cytoplasm, eukaryotic translation initiation factor 3 complex, multi-eIF complex, stress granule	protein binding, translation initiation factor activity		
YMR310C	YMR310C	Putative protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene [Source:SGD;Acc:S000004927]	biological_process	nucleus	molecular_function		
YMR311C	GLC8	Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2 [Source:SGD;Acc:S000004928]	carbohydrate metabolic process, chromosome segregation, glycogen biosynthetic process, glycogen metabolic process, regulation of phosphoprotein phosphatase activity, regulation of signal transduction	cytoplasm, nucleus	enzyme activator activity, protein phosphatase inhibitor activity		
YMR312W	ELP6	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity [Source:SGD;Acc:S000004929]	protein urmylation, regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification	Elongator holoenzyme complex, cytoplasm, nucleus	molecular_function		
YMR313C	TGL3	Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation [Source:SGD;Acc:S000004930]	cell budding, cellular lipid metabolic process, lipid catabolic process, lipid metabolic process, metabolic process, triglyceride catabolic process	integral to membrane, lipid particle, membrane	GTP binding, hydrolase activity, lysophosphatidylethanolamine acyltransferase activity, triglyceride lipase activity		
YMR314W	PRE5	Alpha 6 subunit of the 20S proteasome [Source:SGD;Acc:S000004931]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteolysis involved in cellular protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, mitochondrion, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, molecular_function, peptidase activity, threonine-type endopeptidase activity		
YMR315W	YMR315W	Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site [Source:SGD;Acc:S000004932]	NADPH regeneration, metabolic process, oxidation-reduction process	cytoplasm, nucleus	binding, catalytic activity, oxidoreductase activity		
YMR315W-A	YMR315W-A	Putative protein of unknown function [Source:SGD;Acc:S000028697]	biological_process	cellular_component	molecular_function		
YMR316C-A	YMR316C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene DIA1/YMR316W [Source:SGD;Acc:S000004933]					
YMR316C-B	YMR316C-B	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004934]					
YMR316W	DIA1	Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000004935]	invasive growth in response to glucose limitation, pseudohyphal growth	cytoplasm	molecular_function		
YMR317W	YMR317W	Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene [Source:SGD;Acc:S000004936]	biological_process	cellular_component	molecular_function		
YMR318C	ADH6	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance [Source:SGD;Acc:S000004937]	alcohol metabolic process, cellular aldehyde metabolic process, furaldehyde metabolic process, metabolic process, oxidation-reduction process	soluble fraction	alcohol dehydrogenase (NADP+) activity, binding, catalytic activity, hydroxymethylfurfural reductase (NADH) activity, hydroxymethylfurfural reductase (NADPH) activity, metal ion binding, oxidoreductase activity, zinc ion binding		
YMR319C	FET4	Low-affinity Fe(II) transporter of the plasma membrane [Source:SGD;Acc:S000004938]	copper ion import, intracellular copper ion transport, ion transport, iron ion transport, low-affinity iron ion transport, transmembrane transport, transport, zinc ion transport	integral to membrane, integral to plasma membrane, membrane, plasma membrane	copper ion transmembrane transporter activity, iron ion transmembrane transporter activity		
YMR320W	YMR320W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004939]					
YMR321C	YMR321C	Putative protein of unknown function; proposed to be a palmitoylated membrane protein [Source:SGD;Acc:S000004940]	biological_process	cellular_component	homocysteine S-methyltransferase activity, methyltransferase activity, molecular_function, transferase activity		
YMR322C	SNO4	Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation [Source:SGD;Acc:S000004941]	biological_process	cellular_component	cysteine-type peptidase activity, hydrolase activity, peptidase activity, unfolded protein binding		
YMR323W	ERR3	Protein of unknown function, has similarity to enolases [Source:SGD;Acc:S000004942]	biological_process, glycolysis	cytoplasm, phosphopyruvate hydratase complex	lyase activity, magnesium ion binding, metal ion binding, phosphopyruvate hydratase activity		
YMR324C	YMR324C	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; transcription is AZF1 dependent in glycerol-lactate medium and SLT2 dependent in response to the lipid hydroperoxides [Source:SGD;Acc:S000004943]					
YMR325W	PAU19	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000004944]	biological_process, response to stress	cellular_component	molecular_function		
YMR326C	YMR326C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13 [Source:SGD;Acc:S000004945]					
YNL001W	DOM34	Protein that, with binding partner Hbs1p, facilitates ribosomal subunit dissociation when translation is stalled; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog [Source:SGD;Acc:S000004946]	cell cycle, cell division, meiosis, mitosis, nonfunctional rRNA decay, nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay, nuclear-transcribed mRNA catabolic process, no-go decay, regulation of translation, ribosome disassembly, translation	cytoplasm	endonuclease activity, endoribonuclease activity, hydrolase activity, metal ion binding, nuclease activity, translation release factor activity, codon nonspecific		
YNL002C	RLP7	Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs [Source:SGD;Acc:S000004947]	exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal large subunit biogenesis, ribosome biogenesis, translation	intracellular, nucleolus, nucleus, preribosome, large subunit precursor, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YNL003C	PET8	S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth [Source:SGD;Acc:S000004948]	S-adenosylmethionine transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	S-adenosylmethionine transmembrane transporter activity, binding		
YNL004W	HRB1	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p [Source:SGD;Acc:S000004949]	poly(A)+ mRNA export from nucleus	cytoplasm, heterogeneous nuclear ribonucleoprotein complex, nucleus	RNA binding, nucleic acid binding, nucleotide binding		
YNL005C	MRP7	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004950]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	peptidyltransferase activity, structural constituent of ribosome		
YNL006W	LST8	Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat [Source:SGD;Acc:S000004951]	TOR signaling cascade, establishment or maintenance of actin cytoskeleton polarity, fungal-type cell wall organization, mitochondria-nucleus signaling pathway, regulation of cell growth, signal transduction, transport	Golgi membrane, TORC1 complex, TORC2 complex, endosome membrane, extrinsic to internal side of plasma membrane, membrane, peripheral to membrane of membrane fraction, plasma membrane, vacuolar membrane, vacuole	protein binding, protein kinase activator activity		
YNL007C	SIS1	Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins [Source:SGD;Acc:S000004952]	cell cycle, protein folding, translational initiation	cytoplasm, cytosolic small ribosomal subunit, nucleus	DNA binding, heat shock protein binding, unfolded protein binding		
YNL008C	ASI3	Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals [Source:SGD;Acc:S000004953]	ubiquitin-dependent protein catabolic process	endoplasmic reticulum membrane, integral to membrane, membrane, nuclear inner membrane, nuclear membrane, nucleus	ubiquitin-protein ligase activity		
YNL009W	IDP3	Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids [Source:SGD;Acc:S000004954]	NADPH regeneration, fatty acid beta-oxidation, glyoxylate cycle, isocitrate metabolic process, oxidation-reduction process, tricarboxylic acid cycle	cytoplasm, mitochondrion, peroxisome	NAD binding, isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YNL010W	YNL010W	Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation [Source:SGD;Acc:S000004955]	biological_process, metabolic process	cytoplasm, nucleus	hydrolase activity, molecular_function, phosphatase activity		
YNL011C	YNL011C	Putative protein of unknown function; YNL011C is not an essential gene [Source:SGD;Acc:S000004956]	biological_process	cellular_component	molecular_function		
YNL012W	SPO1	Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B [Source:SGD;Acc:S000004957]	lipid catabolic process, meiosis, metabolic process, phospholipid catabolic process, spore membrane bending pathway, sporulation resulting in formation of a cellular spore	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear membrane, nucleus, prospore membrane	hydrolase activity, phospholipase activity		
YNL013C	YNL013C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W [Source:SGD;Acc:S000004958]					
YNL014W	HEF3	Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells [Source:SGD;Acc:S000004959]	translation, translational elongation	cytosolic ribosome	ATP binding, ATPase activity, RNA binding, binding, nucleoside-triphosphatase activity, nucleotide binding, translation elongation factor activity		
YNL015W	PBI2	Cytosolic inhibitor of vacuolar proteinase B (PRB1), required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion [Source:SGD;Acc:S000004960]	protein transport, regulation of proteolysis, transport, vacuole fusion, non-autophagic	cytoplasm, fungal-type vacuole, nucleus	endopeptidase inhibitor activity, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity		
YNL016W	PUB1	Poly (A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly [Source:SGD;Acc:S000004961]	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of mRNA stability, stress granule assembly	cytoplasm, heterogeneous nuclear ribonucleoprotein complex, nucleus, stress granule	RNA binding, mRNA binding, nucleic acid binding, nucleotide binding, poly(U) RNA binding		
YNL017C	YNL017C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the tRNA ORF tI(AAU)N2 [Source:SGD;Acc:S000004962]					
YNL018C	YNL018C	Putative protein of unknown function [Source:SGD;Acc:S000004963]	biological_process	cellular_component	molecular_function		
YNL019C	YNL019C	Putative protein of unknown function [Source:SGD;Acc:S000004964]	biological_process	cellular_component, integral to membrane, membrane, plasma membrane	molecular_function		
YNL020C	ARK1	Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis [Source:SGD;Acc:S000004965]	actin cortical patch assembly, actin filament organization, cytokinesis, protein phosphorylation, regulation of endocytosis	actin cortical patch, cytoplasm, cytoskeleton, mating projection tip	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YNL021W	HDA1	Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation [Source:SGD;Acc:S000004966]	chromatin modification, gene silencing by RNA, gene silencing involved in chronological cell aging, histone deacetylation, loss of chromatin silencing involved in replicative cell aging, negative regulation of transcription by transcription factor localization, regulation of chromatin silencing at telomere, regulation of transcription by chromatin organization	HDA1 complex, nucleus	chromatin binding, histone deacetylase activity, hydrolase activity		
YNL022C	YNL022C	Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000004967]	biological_process	nucleus	tRNA (cytosine-5-)-methyltransferase activity		
YNL023C	FAP1	Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1 [Source:SGD;Acc:S000004968]	biological_process, regulation of transcription, DNA-dependent	cytoplasm, nucleus	metal ion binding, nucleic acid binding, protein binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YNL024C	YNL024C	Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene [Source:SGD;Acc:S000004969]	biological_process	cytoplasm	S-adenosylmethionine-dependent methyltransferase activity		
YNL024C-A	KSH1	Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; ortholog of human Kish [Source:SGD;Acc:S000028698]	biological_process	Golgi apparatus, cellular_component, extracellular region	molecular_function		
YNL025C	SSN8	Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance [Source:SGD;Acc:S000004970]	negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription by galactose, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter during meiosis	mediator complex, nucleus	cyclin-dependent protein kinase regulator activity		
YNL026W	SAM50	Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 [Source:SGD;Acc:S000004971]	protein complex assembly, protein import into mitochondrial outer membrane, protein transport, transport	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrial sorting and assembly machinery complex, mitochondrion, outer membrane	protein channel activity		
YNL027W	CRZ1	Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation [Source:SGD;Acc:S000004972]	calcium-mediated signaling, regulation of transcription, DNA-dependent	cytoplasm, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YNL028W	YNL028W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004973]					
YNL029C	KTR5	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000004974]	fungal-type cell wall organization, protein N-linked glycosylation, protein glycosylation	Golgi apparatus, integral to membrane, membrane	glycolipid 2-alpha-mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YNL030W	HHF2	Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity [Source:SGD;Acc:S000004975]	chromatin assembly or disassembly, histone H3-K79 methylation, nucleosome assembly, sexual sporulation resulting in formation of a cellular spore	chromosome, nuclear nucleosome, nucleosome, nucleus	DNA binding		
YNL031C	HHT2	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation [Source:SGD;Acc:S000004976]	DNA repair, chromatin assembly or disassembly, mitotic cell cycle spindle assembly checkpoint, nucleosome assembly, rRNA transcription, response to DNA damage stimulus, sexual sporulation resulting in formation of a cellular spore	chromosome, nuclear nucleosome, nucleosome, nucleus	DNA binding		
YNL032W	SIW14	Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm [Source:SGD;Acc:S000004977]	actin filament organization, dephosphorylation, endocytosis, protein dephosphorylation, response to stress	cytoplasm	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity		
YNL033W	YNL033W	Putative protein of unknown function [Source:SGD;Acc:S000004978]	biological_process	cellular_component, integral to membrane, membrane, plasma membrane	molecular_function		
YNL034W	YNL034W	Putative protein of unknown function; YNL034W is not an essential gene [Source:SGD;Acc:S000004979]	biological_process	cellular_component	molecular_function		
YNL035C	YNL035C	Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene [Source:SGD;Acc:S000004980]	biological_process	nucleus	molecular_function, protein binding		
YNL036W	NCE103	Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway [Source:SGD;Acc:S000004981]	carbon utilization, cellular response to oxidative stress	cytoplasm, nucleus	carbonate dehydratase activity, lyase activity, metal ion binding, zinc ion binding		
YNL037C	IDH1	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle [Source:SGD;Acc:S000004982]	glutamate biosynthetic process, isocitrate metabolic process, oxidation-reduction process, tricarboxylic acid cycle	mitochondrial isocitrate dehydrogenase complex (NAD+), mitochondrial matrix, mitochondrial nucleoid, mitochondrion	NAD binding, RNA binding, catalytic activity, isocitrate dehydrogenase (NAD+) activity, magnesium ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YNL038W	GPI15	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein [Source:SGD;Acc:S000004983]	GPI anchor biosynthetic process	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, integral to membrane, membrane	UDP-glycosyltransferase activity, phosphatidylinositol N-acetylglucosaminyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YNL039W	BDP1	Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs [Source:SGD;Acc:S000004984]	RNA polymerase III transcriptional preinitiation complex assembly, positive regulation of transposon integration, transcription from RNA polymerase III promoter	nucleus, transcription factor TFIIIB complex	DNA binding, protein binding		
YNL040W	YNL040W	Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene [Source:SGD;Acc:S000004985]	alanyl-tRNA aminoacylation, biological_process, tRNA aminoacylation, translation	cytoplasm	ATP binding, alanine-tRNA ligase activity, ligase activity, forming aminoacyl-tRNA and related compounds, metal ion binding, molecular_function, nucleotide binding		
YNL041C	COG6	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000004986]	CVT pathway, intra-Golgi vesicle-mediated transport, protein transport, transport	Golgi apparatus, Golgi membrane, Golgi transport complex, membrane	molecular_function		
YNL042W	BOP3	Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury [Source:SGD;Acc:S000004987]	response to mercury ion	cytoplasm, nucleus	molecular_function		
YNL042W-B	YNL042W-B	Putative protein of unknown function [Source:SGD;Acc:S000028850]	biological_process	cellular_component	molecular_function		
YNL043C	YNL043C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W [Source:SGD;Acc:S000004988]					
YNL044W	YIP3	Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p [Source:SGD;Acc:S000004989]	ER to Golgi vesicle-mediated transport	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, integral to membrane, membrane	molecular_function		
YNL045W	LAP2	Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000004990]	cellular lipid metabolic process, leukotriene biosynthetic process, protein catabolic process, proteolysis	cytoplasm, nucleus	aminopeptidase activity, binding, catalytic activity, epoxide hydrolase activity, hydrolase activity, leukotriene-A4 hydrolase activity, metal ion binding, metallopeptidase activity, peptidase activity, zinc ion binding		
YNL046W	YNL046W	Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000004991]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YNL047C	SLM2	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex [Source:SGD;Acc:S000004992]	TOR signaling cascade, actin cytoskeleton organization, actin filament bundle assembly, establishment or maintenance of actin cytoskeleton polarity, regulation of cell growth	membrane, plasma membrane	phosphatidylinositol binding, protein binding		
YNL048W	ALG11	Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER [Source:SGD;Acc:S000004993]	biosynthetic process, oligosaccharide-lipid intermediate biosynthetic process, protein glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	alpha-1,2-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YNL049C	SFB2	Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p [Source:SGD;Acc:S000004994]	ER to Golgi vesicle-mediated transport, cargo loading into COPII-coated vesicle, intracellular protein transport, protein transport, transport, vesicle-mediated transport	COPII vesicle coat, Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane	signal sequence binding, zinc ion binding		
YNL050C	YNL050C	Putative protein of unknown function; YNL050c is not an essential gene [Source:SGD;Acc:S000004995]	biological_process	cellular_component	molecular_function		
YNL051W	COG5	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000004996]	CVT pathway, intra-Golgi vesicle-mediated transport, protein transport, transport	Golgi apparatus, Golgi membrane, Golgi transport complex, membrane	molecular_function		
YNL052W	COX5A	Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth [Source:SGD;Acc:S000004997]	mitochondrial electron transport, cytochrome c to oxygen, oxidation-reduction process	membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion	cytochrome-c oxidase activity, oxidoreductase activity		
YNL053W	MSG5	Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p [Source:SGD;Acc:S000004998]	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, cell cycle, dephosphorylation, inactivation of MAPK activity involved in cell wall biogenesis, inactivation of MAPK activity involved in conjugation with cellular fusion, protein dephosphorylation, regulation of MAPK export from nucleus, regulation of fungal-type cell wall organization	cytoplasm, nucleus	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity		
YNL054W	VAC7	Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock [Source:SGD;Acc:S000004999]	positive regulation of kinase activity, positive regulation of phosphatidylinositol biosynthetic process	PAS complex, cytoplasm, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YNL054W-A	YNL054W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007384]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YNL055C	POR1	Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated [Source:SGD;Acc:S000005000]	DNA transport, anion transport, apoptosis, cell redox homeostasis, ion transport, mitochondrion organization, transmembrane transport, transport	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion, pore complex	porin activity, voltage-gated anion channel activity		
YNL056W	OCA2	Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene [Source:SGD;Acc:S000005001]	biological_process	cytoplasm	hydrolase activity, molecular_function		
YNL057W	YNL057W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005002]					
YNL058C	YNL058C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene [Source:SGD;Acc:S000005003]	biological_process	fungal-type vacuole, integral to membrane, membrane	molecular_function		
YNL059C	ARP5	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes [Source:SGD;Acc:S000005004]	chromatin remodeling, nucleosome mobilization	Ino80 complex, nucleus	ATP-dependent 3'-5' DNA helicase activity		
YNL061W	NOP2	Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles [Source:SGD;Acc:S000005005]	rRNA processing, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor	RNA binding, RNA methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, transferase activity		
YNL062C	GCD10	Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000005006]	regulation of translational initiation, tRNA methylation, tRNA processing, translational initiation	nucleus, tRNA (m1A) methyltransferase complex	RNA binding, tRNA (adenine-N1-)-methyltransferase activity, tRNA binding, translation initiation factor activity		
YNL063W	MTQ1	S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene [Source:SGD;Acc:S000005007]	protein methylation, translational readthrough	mitochondrion	S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, protein methyltransferase activity, transferase activity		
YNL064C	YDJ1	Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family [Source:SGD;Acc:S000005008]	'de novo' protein folding, ER-associated protein catabolic process, protein folding, protein refolding, protein targeting to ER, protein targeting to mitochondrion, protein transport, response to heat, response to stress, transport	TRC complex, cytoplasm, cytosol, microsome, perinuclear region of cytoplasm	ATP binding, ATPase activator activity, heat shock protein binding, metal ion binding, unfolded protein binding		
YNL065W	AQR1	Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids [Source:SGD;Acc:S000005009]	amino acid export, drug transmembrane transport, monocarboxylic acid transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	drug transmembrane transporter activity, monocarboxylic acid transmembrane transporter activity, transporter activity		
YNL066W	SUN4	Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family [Source:SGD;Acc:S000005010]	barrier septum formation, cell cycle, cell division, cellular cell wall organization, mitochondrion organization	cell wall, extracellular region, fungal-type cell wall, mitochondrial matrix	glucosidase activity		
YNL067W	RPL9B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins [Source:SGD;Acc:S000005011]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	rRNA binding, structural constituent of ribosome		
YNL067W-A	YNL067W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007623]					
YNL067W-B	YNL067W-B	Putative protein of unknown function [Source:SGD;Acc:S000028810]	biological_process	cellular_component	molecular_function		
YNL068C	FKH2	Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase [Source:SGD;Acc:S000005012]	chromatin remodeling, negative regulation of transcription from RNA polymerase II promoter, positive regulation of cell cycle, positive regulation of transcription involved in G2/M-phase of mitotic cell cycle, pseudohyphal growth, regulation of transcription, DNA-dependent	nucleus	DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YNL069C	RPL16B	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p [Source:SGD;Acc:S000005013]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, large ribosomal subunit, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YNL070W	TOM7	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex [Source:SGD;Acc:S000005014]	intracellular protein transport, protein import into mitochondrial matrix, protein import into mitochondrial outer membrane, protein transport, transport	integral to membrane, membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion	P-P-bond-hydrolysis-driven protein transmembrane transporter activity, protein channel activity		
YNL071W	LAT1	Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA [Source:SGD;Acc:S000005015]	acetyl-CoA biosynthetic process from pyruvate, metabolic process, pyruvate metabolic process	mitochondrial matrix, mitochondrial pyruvate dehydrogenase complex, mitochondrion, pyruvate dehydrogenase complex	acyltransferase activity, dihydrolipoyllysine-residue acetyltransferase activity, transferase activity		
YNL072W	RNH201	Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome [Source:SGD;Acc:S000005016]	DNA replication, removal of RNA primer, RNA metabolic process	cytoplasm, nucleus, ribonuclease H2 complex	RNA binding, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, ribonuclease H activity		
YNL073W	MSK1	Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys) [Source:SGD;Acc:S000005017]	cytoplasmic tRNA import into mitochondrion, lysyl-tRNA aminoacylation, mitochondrial lysyl-tRNA aminoacylation, mitochondrial translation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, lysine-tRNA ligase activity, nucleic acid binding, nucleotide binding		
YNL074C	MLF3	Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide [Source:SGD;Acc:S000005018]	response to drug	cytoplasm	molecular_function		
YNL075W	IMP4	Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs [Source:SGD;Acc:S000005019]	rRNA processing, ribosome biogenesis, translation	90S preribosome, Mpp10 complex, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	ATP binding, aminoacyl-tRNA ligase activity, rRNA primary transcript binding, single-stranded telomeric DNA binding, snoRNA binding		
YNL076W	MKS1	Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling [Source:SGD;Acc:S000005020]	mitochondria-nucleus signaling pathway, negative regulation of transcription from RNA polymerase II promoter, regulation of nitrogen utilization	cytoplasm, nucleus	molecular_function		
YNL077W	APJ1	Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005021]	biological_process, protein folding	cytoplasm, mitochondrion, nucleus	heat shock protein binding, metal ion binding, unfolded protein binding		
YNL078W	NIS1	Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network [Source:SGD;Acc:S000005022]	regulation of mitosis	cell cortex, cellular bud neck, cytoplasm, nucleus	molecular_function		
YNL079C	TPM1	Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently [Source:SGD;Acc:S000005023]	actin filament bundle assembly, actin filament organization, actin polymerization or depolymerization, budding cell apical bud growth, budding cell isotropic bud growth, establishment of cell polarity, exocytosis, filamentous growth, intracellular mRNA localization, mitochondrion inheritance, pseudohyphal growth, vacuole inheritance, vesicle-mediated transport	actin filament bundle, cellular bud neck contractile ring, cytoplasm, cytoskeleton	actin lateral binding		
YNL080C	EOS1	Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene [Source:SGD;Acc:S000005024]	cellular response to oxidative stress, protein N-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YNL081C	SWS2	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency [Source:SGD;Acc:S000005025]	mitochondrial translation, regulation of sporulation resulting in formation of a cellular spore, translation	cytoplasm, intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, nucleic acid binding, structural constituent of ribosome		
YNL082W	PMS1	ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL [Source:SGD;Acc:S000005026]	DNA repair, meiotic mismatch repair, mismatch repair, response to DNA damage stimulus	MutLalpha complex, cytoplasm, nucleus	ATP binding, ATPase activity, DNA insertion or deletion binding, dinucleotide insertion or deletion binding, double-stranded DNA binding, loop DNA binding, mismatched DNA binding, single-stranded DNA binding		
YNL083W	SAL1	ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains [Source:SGD;Acc:S000005027]	ADP transport, ATP transport, mitochondrial transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	ATP:ADP antiporter activity, binding, calcium ion binding		
YNL084C	END3	EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p [Source:SGD;Acc:S000005028]	actin cortical patch assembly, actin filament organization, ascospore wall assembly, bipolar cellular bud site selection, cytokinesis, endocytosis	actin cortical patch, cytoplasm, cytoskeleton, endosome, endosome membrane, mating projection tip, membrane, plasma membrane	actin binding, calcium ion binding, protein binding, protein binding, bridging		
YNL085W	MKT1	Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more [Source:SGD;Acc:S000005029]	DNA repair, interspecies interaction between organisms, positive regulation of translation, response to DNA damage stimulus	cytoplasm, polysome	nuclease activity		
YNL086W	SNN1	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes [Source:SGD;Acc:S000005030]	biological_process	endosome	molecular_function		
YNL087W	TCB2	Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud [Source:SGD;Acc:S000005031]	biological_process	cellular bud, integral to membrane, membrane, plasma membrane	lipid binding, molecular_function, protein binding		
YNL088W	TOP2	Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis [Source:SGD;Acc:S000005032]	DNA metabolic process, DNA strand elongation involved in DNA replication, DNA topological change, chromatin assembly or disassembly, chromatin remodeling at centromere, mitotic cell cycle G2/M transition decatenation checkpoint, reciprocal meiotic recombination, regulation of mitotic recombination, regulation of transcription, DNA-dependent	chromosome, mitochondrion, nucleus, synaptonemal complex	ATP binding, DNA binding, DNA topoisomerase (ATP-hydrolyzing) activity, DNA topoisomerase activity, isomerase activity, nucleotide binding, sequence-specific DNA binding transcription factor activity		
YNL089C	YNL089C	Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins [Source:SGD;Acc:S000005033]					
YNL090W	RHO2	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly [Source:SGD;Acc:S000005034]	actin filament organization, establishment of cell polarity, fungal-type cell wall organization, microtubule-based process, small GTPase mediated signal transduction	intracellular, membrane, membrane fraction, plasma membrane	GTP binding, GTPase activity, nucleotide binding, signal transducer activity		
YNL091W	NST1	Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 [Source:SGD;Acc:S000005035]	response to salt stress, response to stress	cytoplasm	molecular_function		
YNL092W	YNL092W	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene [Source:SGD;Acc:S000005036]	biological_process	cellular_component	S-adenosylmethionine-dependent methyltransferase activity		
YNL093W	YPT53	Rab family GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis [Source:SGD;Acc:S000005037]	endocytosis, protein targeting to vacuole, protein transport, small GTPase mediated signal transduction, transport	late endosome, membrane, plasma membrane	GTP binding, GTPase activity, nucleotide binding		
YNL094W	APP1	Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization [Source:SGD;Acc:S000005038]	actin cytoskeleton organization	actin cortical patch, actin cytoskeleton, cytoplasm, cytoskeleton	molecular_function		
YNL095C	YNL095C	Putative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene [Source:SGD;Acc:S000005039]	biological_process, transmembrane transport, transport	integral to membrane, membrane	molecular_function		
YNL096C	RPS7B	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins [Source:SGD;Acc:S000005040]	rRNA processing, ribosome biogenesis, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small-subunit processome	structural constituent of ribosome		
YNL097C	PHO23	Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 [Source:SGD;Acc:S000005041]	chromatin modification, histone deacetylation, negative regulation of chromatin silencing at telomere, negative regulation of transcription from RNA polymerase I promoter	Rpd3L complex, Rpd3L-Expanded complex, histone deacetylase complex, nucleus	metal ion binding, methylated histone residue binding, protein binding, zinc ion binding		
YNL097C-B	YNL097C-B	Putative protein of unknown function [Source:SGD;Acc:S000028699]	biological_process	cellular_component	molecular_function		
YNL097W-A	YNL097W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene PHO23/YNL097C [Source:SGD;Acc:S000028700]					
YNL098C	RAS2	GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes [Source:SGD;Acc:S000005042]	Ras protein signal transduction, activation of adenylate cyclase activity, ascospore formation, positive regulation of transcription by galactose, pseudohyphal growth, replicative cell aging, signal transduction, small GTPase mediated signal transduction	intracellular, membrane, plasma membrane, plasma membrane enriched fraction	GTP binding, GTPase activity, nucleotide binding		
YNL099C	OCA1	Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA [Source:SGD;Acc:S000005043]	cellular response to oxidative stress, response to stress	cytoplasm	hydrolase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity		
YNL100W	AIM37	Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays reduced respiratory growth and reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000005044]	biological_process, ion transport, proton transport, transport	mitochondrion	molecular_function		
YNL101W	AVT4	Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000005045]	amino acid export from vacuole, amino acid transport, transport	fungal-type vacuole, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	L-glutamine transmembrane transporter activity, L-isoleucine transmembrane transporter activity, L-tyrosine transmembrane transporter activity, transporter activity		
YNL102W	POL1	Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis [Source:SGD;Acc:S000005046]	DNA replication, DNA synthesis involved in DNA repair, DNA-dependent DNA replication initiation, RNA-dependent DNA replication, lagging strand elongation, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, premeiotic DNA replication	alpha DNA polymerase:primase complex, mitochondrion, nucleus, replication fork	DNA binding, DNA-directed DNA polymerase activity, nucleic acid binding, nucleoside binding, nucleotide binding, nucleotidyltransferase activity, transferase activity		
YNL103W	MET4	Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p [Source:SGD;Acc:S000005047]	cellular amino acid biosynthetic process, cysteine biosynthetic process, methionine biosynthetic process, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to arsenic-containing substance, response to cadmium ion, sulfur amino acid metabolic process	nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, transcription coactivator activity		
YNL103W-A	YNL103W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MET4/YNL104C [Source:SGD;Acc:S000028701]					
YNL104C	LEU4	Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway [Source:SGD;Acc:S000005048]	branched chain family amino acid biosynthetic process, carboxylic acid metabolic process, cellular amino acid biosynthetic process, leucine biosynthetic process, metabolic process	cytoplasm, mitochondrion	2-isopropylmalate synthase activity, catalytic activity, transferase activity, transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer		
YNL105W	RRT16	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription [Source:SGD;Acc:S000005049]					
YNL106C	INP52	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain [Source:SGD;Acc:S000005050]	endocytosis, lipid metabolic process, phosphatidylinositol dephosphorylation, protein transport, transport	actin cortical patch, cytoplasm, cytoskeleton, mating projection tip, vesicular fraction	hydrolase activity, inositol or phosphatidylinositol phosphatase activity, phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-3-phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-4-phosphate phosphatase activity, phosphoric ester hydrolase activity		
YNL107W	YAF9	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain [Source:SGD;Acc:S000005051]	DNA repair, chromatin modification, chromatin remodeling, chromatin silencing at telomere, histone exchange, regulation of transcription, DNA-dependent, response to DNA damage stimulus	NuA4 histone acetyltransferase complex, Swr1 complex, cytoplasm, nucleus	molecular_function		
YNL108C	YNL108C	Putative protein of unknown function with similarity to Tfc7p and prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000005052]	biological_process	cytoplasm, nucleus	molecular_function		
YNL109W	YNL109W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C [Source:SGD;Acc:S000005053]					
YNL110C	NOP15	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm [Source:SGD;Acc:S000005054]	cytokinesis, actomyosin contractile ring assembly, rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis	cytoplasm, nucleolus, nucleus, preribosome, large subunit precursor, ribonucleoprotein complex	RNA binding, molecular_function, nucleic acid binding, nucleotide binding		
YNL111C	CYB5	Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation [Source:SGD;Acc:S000005055]	electron transport chain, sterol biosynthetic process, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome	electron carrier activity, heme binding, metal ion binding		
YNL112W	DBP2	Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing [Source:SGD;Acc:S000005056]	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, rRNA processing, ribosome biogenesis	cytoplasm, mitochondrion, nucleus	ATP binding, ATP-dependent helicase activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YNL113W	RPC19	RNA polymerase subunit AC19, common to RNA polymerases I and III [Source:SGD;Acc:S000005057]	tRNA transcription from RNA polymerase III promoter, transcription from RNA polymerase I promoter	DNA-directed RNA polymerase I complex, DNA-directed RNA polymerase III complex, nucleolus, nucleus	DNA binding, DNA-directed RNA polymerase activity, protein dimerization activity		
YNL114C	YNL114C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit [Source:SGD;Acc:S000005058]					
YNL115C	YNL115C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene [Source:SGD;Acc:S000005059]	biological_process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YNL116W	DMA2	Protein involved in ubiquitination; plays a role in regulating spindle position and orientation; functionally redundant with Dma1p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr [Source:SGD;Acc:S000005060]	cell cycle, cell division, establishment of mitotic spindle orientation, mitosis, mitotic cell cycle spindle assembly checkpoint, protein autoubiquitination, septin ring assembly	cytoplasm	ligase activity, metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YNL117W	MLS1	Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium [Source:SGD;Acc:S000005061]	glyoxylate cycle, tricarboxylic acid cycle	cytoplasm, glyoxysome, peroxisomal matrix, peroxisome	catalytic activity, malate synthase activity, transferase activity		
YNL118C	DCP2	Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family [Source:SGD;Acc:S000005062]	deadenylation-dependent decapping of nuclear-transcribed mRNA, deadenylation-independent decapping of nuclear-transcribed mRNA, mRNA processing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, stress granule assembly	cytoplasm, cytoplasmic mRNA processing body, nucleus	RNA binding, hydrolase activity, m7G(5')pppN diphosphatase activity, mRNA binding, manganese ion binding, metal ion binding		
YNL119W	NCS2	Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae [Source:SGD;Acc:S000005063]	invasive growth in response to glucose limitation, protein urmylation, pseudohyphal growth, tRNA processing, tRNA wobble position uridine thiolation	cytoplasm	molecular_function		
YNL120C	YNL120C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene [Source:SGD;Acc:S000005064]					
YNL121C	TOM70	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins [Source:SGD;Acc:S000005065]	intracellular protein transport, protein import into mitochondrial inner membrane, protein import into mitochondrial matrix	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion	P-P-bond-hydrolysis-driven protein transmembrane transporter activity, binding, mitochondrion targeting sequence binding, protein binding, protein channel activity		
YNL122C	YNL122C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene [Source:SGD;Acc:S000005066]	biological_process, translation	intracellular, mitochondrion, ribonucleoprotein complex, ribosome	molecular_function, structural constituent of ribosome		
YNL123W	NMA111	Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases [Source:SGD;Acc:S000005067]	apoptosis, cellular lipid metabolic process, cellular response to heat, protein catabolic process, proteolysis	nucleus	catalytic activity, hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity		
YNL124W	NAF1	RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p [Source:SGD;Acc:S000005068]	box H/ACA snoRNP assembly, rRNA processing, ribosome biogenesis	box H/ACA snoRNP complex, nucleoplasm, nucleus, ribonucleoprotein complex	RNA binding, pseudouridine synthase activity, snoRNA binding		
YNL125C	ESBP6	Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane [Source:SGD;Acc:S000005069]	transmembrane transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion	symporter activity, transporter activity		
YNL126W	SPC98	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque [Source:SGD;Acc:S000005070]	microtubule cytoskeleton organization, microtubule nucleation, mitotic spindle organization in nucleus	cytoplasm, cytoskeleton, gamma-tubulin small complex, spindle pole body, inner plaque of spindle pole body, microtubule, microtubule organizing center, nucleus, outer plaque of spindle pole body, spindle pole, spindle pole body	structural constituent of cytoskeleton		
YNL127W	FAR11	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 [Source:SGD;Acc:S000005071]	cell cycle, re-entry into mitotic cell cycle after pheromone arrest	cellular_component	molecular_function		
YNL128W	TEP1	Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation [Source:SGD;Acc:S000005072]	ascospore wall assembly, dephosphorylation, inositol lipid-mediated signaling, phosphatidylinositol dephosphorylation, protein dephosphorylation	cellular_component	hydrolase activity, inositol or phosphatidylinositol phosphatase activity, phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, protein binding, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity		
YNL129W	NRK1	Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis [Source:SGD;Acc:S000005073]	NAD biosynthesis via nicotinamide riboside salvage pathway, NAD biosynthetic process, metabolic process, nicotinamide riboside metabolic process, pyridine nucleotide biosynthetic process	cytoplasm	ATP binding, kinase activity, metal ion binding, nicotinic acid riboside kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, ribosylnicotinamide kinase activity, transferase activity		
YNL130C	CPT1	Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription [Source:SGD;Acc:S000005074]	CDP-choline pathway, phospholipid biosynthetic process	Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome, mitochondrial outer membrane	diacylglycerol cholinephosphotransferase activity, phosphotransferase activity, for other substituted phosphate groups, transferase activity		
YNL130C-A	DGR1	Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose [Source:SGD;Acc:S000028579]	biological_process	cellular_component, mitochondrion	molecular_function		
YNL131W	TOM22	Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes [Source:SGD;Acc:S000005075]	intracellular protein transport, protein import into mitochondrial matrix, protein import into mitochondrial outer membrane, protein transport, transmembrane transport, transport	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion	protein channel activity, receptor activity		
YNL132W	KRE33	Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance [Source:SGD;Acc:S000005076]	ribosomal small subunit biogenesis	90S preribosome, nucleolus, nucleus	ATP binding, molecular_function, nucleotide binding		
YNL133C	FYV6	Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining [Source:SGD;Acc:S000005077]	double-strand break repair via nonhomologous end joining	chromosome, telomeric region, nucleus	molecular_function		
YNL134C	YNL134C	Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS [Source:SGD;Acc:S000005078]	biological_process, metabolic process, oxidation-reduction process	cytoplasm, nucleus	alcohol dehydrogenase (NADP+) activity, binding, catalytic activity, oxidoreductase activity, zinc ion binding		
YNL135C	FPR1	Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function [Source:SGD;Acc:S000005079]	chromatin organization, homoserine metabolic process, protein folding	cytoplasm, mitochondrion, nucleus	isomerase activity, macrolide binding, peptidyl-prolyl cis-trans isomerase activity		
YNL136W	EAF7	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A [Source:SGD;Acc:S000005080]	DNA repair, chromatin modification, histone acetylation, regulation of transcription from RNA polymerase II promoter, response to DNA damage stimulus	H4/H2A histone acetyltransferase complex, NuA4 histone acetyltransferase complex, histone acetyltransferase complex, nucleus	molecular_function		
YNL137C	NAM9	Mitochondrial ribosomal component of the small subunit [Source:SGD;Acc:S000005081]	mitochondrial translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YNL138W	SRV2	CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis [Source:SGD;Acc:S000005082]	Ras protein signal transduction, cytoskeleton organization, pseudohyphal growth	actin cortical patch, cytoplasm, cytoskeleton, mating projection tip	actin binding, adenylate cyclase binding, binding, cytoskeletal protein binding		
YNL138W-A	YSF3	Component of the SF3b subcomplex of the U2 snRNP, essential protein required for for splicing and for assembly of SF3b [Source:SGD;Acc:S000028509]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome, spliceosome assembly	U2 snRNP, nucleus	molecular_function		
YNL139C	THO2	Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids [Source:SGD;Acc:S000005083]	DNA recombination, mRNA 3'-end processing, mRNA export from nucleus, transcription elongation from RNA polymerase II promoter, transcription-coupled nucleotide-excision repair	THO complex part of transcription export complex, nucleoplasmic THO complex, nucleus	DNA binding, nucleic acid binding		
YNL140C	YNL140C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene THO2/YNL139C [Source:SGD;Acc:S000005084]					
YNL141W	AAH1	Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome [Source:SGD;Acc:S000005085]	adenine catabolic process, hypoxanthine salvage, nucleotide metabolic process, purine ribonucleoside monophosphate biosynthetic process, purine-containing compound salvage	cytoplasm, nucleus	adenine deaminase activity, adenosine deaminase activity, deaminase activity, hydrolase activity, metal ion binding		
YNL142W	MEP2	Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation [Source:SGD;Acc:S000005086]	ammonium transport, nitrogen utilization, pseudohyphal growth, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	ammonium transmembrane transporter activity		
YNL143C	YNL143C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005087]					
YNL144C	YNL144C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene [Source:SGD;Acc:S000005088]	biological_process	mitochondrion	molecular_function		
YNL144W-A	YNL144W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YNL144C [Source:SGD;Acc:S000028702]					
YNL145W	MFA2	Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1 [Source:SGD;Acc:S000005089]	pheromone-dependent signal transduction involved in conjugation with cellular fusion	extracellular region, membrane, plasma membrane	mating pheromone activity, pheromone activity		
YNL146C-A	YNL146C-A	Putative protein of unknown function [Source:SGD;Acc:S000028851]	biological_process	cellular_component	molecular_function		
YNL146W	YNL146W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene [Source:SGD;Acc:S000005090]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YNL147W	LSM7	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000005091]	RNA splicing, mRNA processing, maturation of SSU-rRNA, nuclear mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, rRNA processing, tRNA processing	U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytoplasm, nucleolus, nucleus, ribonucleoprotein complex, small nucleolar ribonucleoprotein complex	RNA binding		
YNL148C	ALF1	Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance [Source:SGD;Acc:S000005092]	post-chaperonin tubulin folding pathway, protein folding	cytoplasm, cytoskeleton, microtubule, nucleus	alpha-tubulin binding, microtubule binding		
YNL149C	PGA2	Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect [Source:SGD;Acc:S000005093]	protein transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear envelope, nuclear membrane, nucleus	molecular_function		
YNL150W	YNL150W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking [Source:SGD;Acc:S000005094]					
YNL151C	RPC31	RNA polymerase III subunit C31 [Source:SGD;Acc:S000005095]	tRNA transcription from RNA polymerase III promoter, transcription initiation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex, nucleus	DNA binding, DNA-directed RNA polymerase activity, nucleotidyltransferase activity, transferase activity		
YNL152W	INN1	Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function [Source:SGD;Acc:S000005096]	cell cycle, cell division, chromosome organization, cytokinesis after mitosis, mitosis	cellular bud neck, cellular bud neck contractile ring, cytoplasm	phospholipid binding, protein binding		
YNL153C	GIM3	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it [Source:SGD;Acc:S000005097]	protein folding, tubulin complex assembly	cytoplasm, prefoldin complex	chaperone binding, tubulin binding, unfolded protein binding		
YNL154C	YCK2	Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p [Source:SGD;Acc:S000005098]	cell morphogenesis, cytokinesis, endocytosis, protein phosphorylation, response to glucose stimulus	cellular bud neck, mating projection, membrane, plasma membrane, plasma membrane enriched fraction	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YNL155W	YNL155W	Putative protein of unknown function, contains DHHC domain, also predicted to have thiol-disulfide oxidoreductase active site [Source:SGD;Acc:S000005099]	biological_process	cytoplasm, nucleus	metal ion binding, molecular_function, zinc ion binding		
YNL156C	NSG2	Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins [Source:SGD;Acc:S000005100]	sterol biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane			
YNL157W	IGO1	Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p [Source:SGD;Acc:S000005101]	mRNA stabilization	cytoplasm, cytoplasmic mRNA processing body, nucleus	molecular_function		
YNL158W	PGA1	Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes [Source:SGD;Acc:S000005102]	GPI anchor biosynthetic process	integral to endoplasmic reticulum membrane, integral to membrane, mannosyltransferase complex, membrane, nuclear envelope, nuclear membrane, nucleus	mannosyltransferase activity		
YNL159C	ASI2	Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals [Source:SGD;Acc:S000005103]	ubiquitin-dependent protein catabolic process	integral to membrane, membrane, nuclear inner membrane	molecular_function		
YNL160W	YGP1	Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p [Source:SGD;Acc:S000005104]	cell wall assembly, cellular amino acid metabolic process	extracellular region	molecular_function		
YNL161W	CBK1	Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation [Source:SGD;Acc:S000005105]	budding cell apical bud growth, cell morphogenesis involved in conjugation with cellular fusion, establishment or maintenance of actin cytoskeleton polarity, establishment or maintenance of cell polarity, protein localization to nucleus, protein phosphorylation, regulation of exit from mitosis, regulation of mating projection assembly, response to pheromone involved in conjugation with cellular fusion	cell cortex, cellular bud, cellular bud neck, cellular bud tip, cytoplasm, incipient cellular bud site, mating projection tip, nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YNL162W	RPL42A	Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein [Source:SGD;Acc:S000005106]	response to antibiotic, response to cycloheximide, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YNL162W-A	YNL162W-A	Putative protein of unknown function; identified by homology [Source:SGD;Acc:S000007624]	biological_process	cytoplasm, nucleus	molecular_function		
YNL163C	RIA1	Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p) [Source:SGD;Acc:S000005107]	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal large subunit biogenesis, ribosome biogenesis	cytoplasm	GTP binding, GTPase activity, hydrolase activity, nucleotide binding		
YNL164C	IBD2	Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p [Source:SGD;Acc:S000005108]	cell cycle, cell division, mitosis, mitotic cell cycle spindle assembly checkpoint	cytoplasm, cytoskeleton, nucleus, spindle pole	molecular_function		
YNL165W	YNL165W	Putative protein of unknown function; YNL165W is not an essential gene [Source:SGD;Acc:S000005109]	biological_process	cellular_component	molecular_function		
YNL166C	BNI5	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner [Source:SGD;Acc:S000005110]	cell cycle, cytokinesis, septin ring assembly	cellular bud, cellular bud neck, cellular bud neck septin ring, cytoplasm	molecular_function		
YNL167C	SKO1	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses [Source:SGD;Acc:S000005111]	negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	cytosol, nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YNL168C	FMP41	Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005112]	biological_process, metabolic process, response to stress	mitochondrion	catalytic activity, hydrolase activity, metal ion binding, molecular_function		
YNL169C	PSD1	Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine [Source:SGD;Acc:S000005113]	phosphatidylcholine biosynthetic process, phospholipid biosynthetic process	membrane, mitochondrial inner membrane, mitochondrion	carboxy-lyase activity, lyase activity, phosphatidylserine decarboxylase activity		
YNL170W	YNL170W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005114]					
YNL171C	YNL171C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005115]					
YNL172W	APC1	Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000005116]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, cyclin catabolic process, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, protein ubiquitination	anaphase-promoting complex, cytoplasm, cytoskeleton, nucleus, spindle pole	ubiquitin-protein ligase activity		
YNL173C	MDG1	Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations [Source:SGD;Acc:S000005117]	pheromone-dependent signal transduction involved in conjugation with cellular fusion	membrane, membrane raft, plasma membrane	molecular_function		
YNL174W	YNL174W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene NOP13/YNL175C [Source:SGD;Acc:S000005118]					
YNL175C	NOP13	Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM) [Source:SGD;Acc:S000005119]	biological_process	nucleolus, nucleus, preribosome	RNA binding, nucleic acid binding, nucleotide binding		
YNL176C	YNL176C	Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p [Source:SGD;Acc:S000005120]	biological_process	fungal-type vacuole, integral to membrane, membrane	molecular_function		
YNL177C	MRPL22	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000005121]	mitochondrial translation, translation	intracellular, large ribosomal subunit, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YNL178W	RPS3	Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins [Source:SGD;Acc:S000005122]	rRNA export from nucleus, translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, preribosome, small subunit precursor, ribonucleoprotein complex, ribosome, small ribosomal subunit	DNA-(apurinic or apyrimidinic site) lyase activity, RNA binding, structural constituent of ribosome		
YNL179C	YNL179C	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance [Source:SGD;Acc:S000005123]					
YNL180C	RHO5	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity [Source:SGD;Acc:S000005124]	Rho protein signal transduction, small GTPase mediated signal transduction	cytoplasm, intracellular, membrane, membrane fraction, nucleus, plasma membrane	GTP binding, GTPase activity, nucleotide binding		
YNL181W	YNL181W	Putative oxidoreductase; required for cell viability [Source:SGD;Acc:S000005125]	biological_process, metabolic process	endoplasmic reticulum, integral to membrane, membrane, nuclear envelope	binding, catalytic activity, oxidoreductase activity, oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor		
YNL182C	IPI3	Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles [Source:SGD;Acc:S000005126]	rRNA processing, ribosomal large subunit assembly, ribosome biogenesis	nucleoplasm, nucleus	molecular_function, protein binding		
YNL183C	NPR1	Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation [Source:SGD;Acc:S000005127]	protein phosphorylation, regulation of nitrogen utilization	Golgi apparatus, cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YNL184C	YNL184C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005128]					
YNL185C	MRPL19	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000005129]	mitochondrial translation, translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YNL186W	UBP10	Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus [Source:SGD;Acc:S000005130]	chromatin silencing at telomere, protein deubiquitination, ubiquitin-dependent protein catabolic process	chromosome, telomeric region, nucleus	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YNL187W	SWT21	Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats [Source:SGD;Acc:S000005131]	nuclear mRNA splicing, via spliceosome	nucleus, small nuclear ribonucleoprotein complex	molecular_function, protein binding		
YNL188W	KAR1	Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p [Source:SGD;Acc:S000005132]	cell cycle, cell division, karyogamy involved in conjugation with cellular fusion, mitosis, spindle pole body duplication in nuclear envelope	cytoplasm, cytoskeleton, half bridge of spindle pole body, microtubule, nucleus, spindle pole body			
YNL189W	SRP1	Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation [Source:SGD;Acc:S000005133]	intracellular protein transport, protein import into nucleus, protein targeting to membrane, protein transport, transport	cytoplasm, nuclear exosome (RNase complex), nuclear pore, nucleus, perinuclear region of cytoplasm	binding, protein binding, protein transporter activity		
YNL190W	YNL190W	Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site [Source:SGD;Acc:S000005134]	cellular response to water deprivation	fungal-type cell wall	molecular_function		
YNL191W	DUG3	Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) [Source:SGD;Acc:S000005135]	glutamine metabolic process, glutathione catabolic process, metabolic process	cytoplasm	carbon-nitrogen ligase activity, with glutamine as amido-N-donor, omega peptidase activity, peptidase activity, transferase activity		
YNL192W	CHS1	Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor [Source:SGD;Acc:S000005136]	cell budding, cellular cell wall organization, chitin biosynthetic process, cytokinesis, completion of separation	chitosome, integral to membrane, membrane, membrane fraction, plasma membrane	chitin synthase activity, transferase activity, transferase activity, transferring glycosyl groups		
YNL193W	YNL193W	Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis [Source:SGD;Acc:S000005137]	biological_process	cellular_component	molecular_function		
YNL194C	YNL194C	Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000005138]	ascospore formation	cell cortex, cytoplasm, endoplasmic reticulum, integral to membrane, membrane, plasma membrane, plasma membrane enriched fraction	molecular_function		
YNL195C	YNL195C	Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005139]	biological_process	mitochondrion	molecular_function		
YNL196C	SLZ1	Sporulation-specific protein with a leucine zipper motif [Source:SGD;Acc:S000005140]	biological_process	cellular_component	molecular_function		
YNL197C	WHI3	RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start [Source:SGD;Acc:S000005141]	cell cycle, cytoplasmic sequestering of protein, invasive growth in response to glucose limitation, pseudohyphal growth, regulation of cell size	cytoplasm	RNA binding, nucleic acid binding, nucleotide binding		
YNL198C	YNL198C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005142]					
YNL199C	GCR2	Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p [Source:SGD;Acc:S000005143]	positive regulation of glycolysis, positive regulation of transcription from RNA polymerase II promoter	nuclear envelope, nucleus			
YNL200C	YNL200C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005144]	biological_process	cytoplasm, mitochondrion	molecular_function		
YNL201C	PSY2	Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; putative homolog of mammalian R3 [Source:SGD;Acc:S000005145]	response to DNA damage stimulus, response to drug	nucleus	binding, molecular_function		
YNL202W	SPS19	Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate [Source:SGD;Acc:S000005146]	ascospore formation, fatty acid catabolic process, metabolic process, oxidation-reduction process, sporulation resulting in formation of a cellular spore	peroxisomal matrix, peroxisome	2,4-dienoyl-CoA reductase (NADPH) activity, binding, catalytic activity, oxidoreductase activity		
YNL203C	YNL203C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005147]					
YNL204C	SPS18	Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation [Source:SGD;Acc:S000005148]	regulation of ARF GTPase activity, sporulation resulting in formation of a cellular spore	cellular_component	ARF GTPase activator activity, GTPase activator activity, metal ion binding, molecular_function, zinc ion binding		
YNL205C	YNL205C	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005149]					
YNL206C	RTT106	Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition [Source:SGD;Acc:S000005150]	DNA replication-dependent nucleosome assembly, chromatin silencing at silent mating-type cassette, chromatin silencing at telomere, negative regulation of transposition, RNA-mediated, nucleosome assembly, transposition	chromosome, nucleus	histone binding		
YNL207W	RIO2	Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p [Source:SGD;Acc:S000005151]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), protein phosphorylation, ribosome biogenesis	cytoplasm, cytosol, nucleus	ATP binding, catalytic activity, kinase activity, nucleocytoplasmic transporter activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YNL208W	YNL208W	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi [Source:SGD;Acc:S000005152]	biological_process	mitochondrion, outer membrane, ribosome	molecular_function		
YNL209W	SSB2	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1 [Source:SGD;Acc:S000005153]	'de novo' cotranslational protein folding, cellular response to glucose starvation, rRNA processing, regulation of translational fidelity, response to stress, ribosomal subunit export from nucleus, translation	cytoplasm, plasma membrane enriched fraction, polysome	ATP binding, ATPase activity, nucleotide binding, unfolded protein binding		
YNL210W	MER1	Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination [Source:SGD;Acc:S000005154]	meiosis, positive regulation of nuclear mRNA splicing, via spliceosome, reciprocal meiotic recombination	U1 snRNP, nucleus	RNA binding, mRNA binding		
YNL211C	YNL211C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene [Source:SGD;Acc:S000005155]	biological_process	mitochondrion	molecular_function		
YNL212W	VID27	Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth [Source:SGD;Acc:S000005156]	biological_process	cytoplasm	molecular_function		
YNL213C	RRG9	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005157]	mitochondrial genome maintenance, mitochondrion organization	mitochondrion	molecular_function		
YNL214W	PEX17	Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis [Source:SGD;Acc:S000005158]	protein import into peroxisome matrix, docking, protein transport, transport	membrane, peroxisomal membrane, peroxisome			
YNL215W	IES2	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; essential for growth under anaerobic conditions [Source:SGD;Acc:S000005159]	biological_process	nucleus	molecular_function		
YNL216W	RAP1	DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure [Source:SGD;Acc:S000005160]	chromatin silencing, chromatin silencing at telomere, protection from non-homologous end joining at telomere, telomere maintenance via telomerase	chromosome, telomeric region, intracellular, nuclear envelope, nuclear telomere cap complex, nucleus	DNA bending activity, DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, telomeric DNA binding		
YNL217W	YNL217W	Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate [Source:SGD;Acc:S000005161]	biological_process	fungal-type vacuole, vacuole	hydrolase activity, phosphatase activity		
YNL218W	MGS1	Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP) [Source:SGD;Acc:S000005162]	DNA repair, DNA replication, Okazaki fragment processing, defense response, regulation of DNA repair	cytoplasm, nucleus	ATP binding, DNA binding, DNA strand annealing activity, enzyme activator activity, metal ion binding, nucleoside-triphosphatase activity, nucleotide binding, single-stranded DNA-dependent ATPase activity, ubiquitin binding		
YNL219C	ALG9	Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation [Source:SGD;Acc:S000005163]	GPI anchor biosynthetic process, dolichol-linked oligosaccharide biosynthetic process, protein glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, intrinsic to endoplasmic reticulum membrane, membrane	mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YNL220W	ADE12	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence [Source:SGD;Acc:S000005164]	purine nucleotide biosynthetic process	cytoplasm	DNA replication origin binding, GTP binding, adenylosuccinate synthase activity, ligase activity, magnesium ion binding, metal ion binding, nucleotide binding		
YNL221C	POP1	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P [Source:SGD;Acc:S000005165]	RNA processing, intronic box C/D snoRNA processing, mRNA cleavage, rRNA processing, tRNA 5'-leader removal, tRNA processing	cytoplasm, nucleolar ribonuclease P complex, nucleus, ribonuclease MRP complex	hydrolase activity, ribonuclease MRP activity, ribonuclease P activity		
YNL222W	SSU72	Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo [Source:SGD;Acc:S000005166]	mRNA processing, rRNA processing, snoRNA transcription, termination of RNA polymerase II transcription, termination of RNA polymerase II transcription, exosome-dependent, termination of RNA polymerase II transcription, poly(A)-coupled, transcription initiation from RNA polymerase II promoter	mRNA cleavage and polyadenylation specificity factor complex, nucleus	RNA binding, hydrolase activity, phosphoprotein phosphatase activity, phosphoric ester hydrolase activity, protein tyrosine phosphatase activity		
YNL223W	ATG4	Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation [Source:SGD;Acc:S000005167]	C-terminal protein lipidation, CVT pathway, autophagic vacuole assembly, autophagy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein delipidation, protein maturation by peptide bond cleavage, protein targeting to membrane, protein transport, transport	cytoplasm, cytosol, nucleus	cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity		
YNL224C	SQS1	Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles [Source:SGD;Acc:S000005168]	RNA splicing, mRNA processing, maturation of SSU-rRNA, nuclear mRNA splicing, via spliceosome, positive regulation of ATPase activity, positive regulation of helicase activity, rRNA processing	90S preribosome, cytoplasm, intracellular, nucleus, preribosome, large subunit precursor, preribosome, small subunit precursor	molecular_function, nucleic acid binding		
YNL225C	CNM67	Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration [Source:SGD;Acc:S000005169]	cell cycle, cell division, meiosis, microtubule nucleation, mitotic spindle organization, sporulation resulting in formation of a cellular spore	cytoplasm, cytoskeleton, nucleus, outer plaque of spindle pole body, spindle pole body	structural constituent of cytoskeleton		
YNL226W	YNL226W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C [Source:SGD;Acc:S000005170]					
YNL227C	JJJ1	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis [Source:SGD;Acc:S000005171]	endocytosis, protein folding, rRNA processing, regulation of cell size, ribosomal large subunit biogenesis, ribosomal subunit export from nucleus	cytoplasm, cytosol, cytosolic large ribosomal subunit, intracellular, mitochondrion, nucleolus, nucleus	ATPase activator activity, heat shock protein binding, metal ion binding, unfolded protein binding, zinc ion binding		
YNL228W	YNL228W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 [Source:SGD;Acc:S000005172]					
YNL229C	URE2	Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion [Source:SGD;Acc:S000005173]	cytoplasmic sequestering of transcription factor, nitrate assimilation, protein urmylation, regulation of nitrogen utilization, response to aluminum ion	cytosol, soluble fraction	glutathione peroxidase activity, phosphoprotein binding, protein binding, transcription corepressor activity		
YNL230C	ELA1	Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21; subunit of the Elongin-Cullin-Socs (ECS) ligase complex [Source:SGD;Acc:S000005174]	protein ubiquitination involved in ubiquitin-dependent protein catabolic process, transcription elongation from RNA polymerase II promoter	Cul3-RING ubiquitin ligase complex, integral to membrane, nucleus, transcription elongation factor complex	protein binding		
YNL231C	PDR16	Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p [Source:SGD;Acc:S000005175]	lipid transport, phospholipid transport, response to drug, sterol biosynthetic process, transport	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, lipid particle, membrane, microsome, plasma membrane enriched fraction	phosphatidylinositol transporter activity		
YNL232W	CSL4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) [Source:SGD;Acc:S000005176]	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ncRNA 3'-end processing, nonfunctional rRNA decay, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, polyadenylation-dependent snoRNA 3'-end processing, rRNA processing	cytoplasm, cytoplasmic exosome (RNase complex), exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleus	RNA binding, molecular_function		
YNL233W	BNI4	Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p [Source:SGD;Acc:S000005177]	asymmetric protein localization, barrier septum formation, chitin biosynthetic process	cellular bud neck, cellular bud neck septin collar, incipient cellular bud site, septin ring			
YNL234W	YNL234W	Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1 [Source:SGD;Acc:S000005178]	biological_process, oxygen transport	cytoplasm	heme binding, iron ion binding, oxygen binding		
YNL235C	YNL235C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex [Source:SGD;Acc:S000005179]					
YNL236W	SIN4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription [Source:SGD;Acc:S000005180]	transcription from RNA polymerase II promoter	mediator complex, nucleus			
YNL237W	YTP1	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins [Source:SGD;Acc:S000005181]	biological_process	integral to membrane, membrane	molecular_function		
YNL238W	KEX2	Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway [Source:SGD;Acc:S000005182]	peptide pheromone maturation, proteolysis	Golgi apparatus, integral to membrane, membrane, trans-Golgi network	hydrolase activity, metal ion binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity		
YNL239W	LAP3	Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH [Source:SGD;Acc:S000005183]	homocysteine catabolic process, proteolysis, response to antibiotic	cytoplasm, mitochondrion	DNA binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, nucleic acid binding, peptidase activity		
YNL240C	NAR1	Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf [Source:SGD;Acc:S000005184]	iron-sulfur cluster assembly	cytoplasm, cytosol, membrane, nucleus	4 iron, 4 sulfur cluster binding, ferredoxin hydrogenase activity, iron-sulfur cluster binding, metal ion binding		
YNL241C	ZWF1	Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia [Source:SGD;Acc:S000005185]	NADPH regeneration, carbohydrate metabolic process, glucose metabolic process, metabolic process, oxidation-reduction process, pentose-phosphate shunt, oxidative branch, response to hydrogen peroxide	cytoplasm	binding, catalytic activity, glucose-6-phosphate dehydrogenase activity, oxidoreductase activity		
YNL242W	ATG2	Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria [Source:SGD;Acc:S000005186]	CVT pathway, autophagic vacuole assembly, autophagy, mitochondrion degradation, peroxisome degradation, piecemeal microautophagy of nucleus, protein transport, transport	cytoplasm, extrinsic to membrane, pre-autophagosomal structure	molecular_function		
YNL243W	SLA2	Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo [Source:SGD;Acc:S000005187]	actin filament organization, bipolar cellular bud site selection, endocytosis, exocytosis, fungal-type cell wall organization	actin cortical patch, cell cortex, cellular bud tip, cytoplasm, cytoskeleton, incipient cellular bud site, integral to membrane, mating projection tip, membrane, plasma membrane	actin binding, phospholipid binding, protein binding, bridging		
YNL244C	SUI1	Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase [Source:SGD;Acc:S000005188]	regulation of translation, translation, translational initiation	multi-eIF complex	translation initiation factor activity		
YNL245C	CWC25	Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p [Source:SGD;Acc:S000005189]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U2-type spliceosomal complex, nucleus, spliceosomal complex	molecular_function		
YNL246W	VPS75	NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair [Source:SGD;Acc:S000005190]	double-strand break repair via nonhomologous end joining, nucleosome assembly, positive regulation of histone acetylation, protein transport, transport	chromatin, nucleus	acetyltransferase activator activity, histone binding		
YNL247W	YNL247W	Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000005191]	cysteinyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, ribosome	ATP binding, aminoacyl-tRNA ligase activity, cysteine-tRNA ligase activity, ligase activity, metal ion binding, nucleotide binding		
YNL248C	RPA49	RNA polymerase I subunit A49 [Source:SGD;Acc:S000005192]	regulation of cell size, transcription elongation from RNA polymerase I promoter, transcription of nuclear rRNA large RNA polymerase I transcript	DNA-directed RNA polymerase I complex, nucleolus, nucleus	DNA binding, DNA-directed RNA polymerase activity, molecular_function, nucleotidyltransferase activity, transferase activity		
YNL249C	MPA43	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005193]	biological_process, carbohydrate metabolic process	mitochondrion	molecular_function, phosphotransferase activity, alcohol group as acceptor		
YNL250W	RAD50	Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining [Source:SGD;Acc:S000005194]	DNA repair, base-excision repair, double-strand break repair via break-induced replication, double-strand break repair via nonhomologous end joining, meiosis, meiotic DNA double-strand break formation, meiotic DNA double-strand break processing, negative regulation of endodeoxyribonuclease activity, response to DNA damage stimulus, telomere maintenance, telomere maintenance via recombination	Mre11 complex, mitochondrion, nucleus	ATP binding, ATPase activity, G-quadruplex DNA binding, adenylate kinase activity, double-stranded DNA binding, double-stranded telomeric DNA binding, hydrolase activity, metal ion binding, nuclease activity, nucleotide binding, single-stranded telomeric DNA binding, telomeric DNA binding, zinc ion binding		
YNL251C	NRD1	RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5; required for transcription termination and 3' end maturation of nonpolyadenylated RNAs [Source:SGD;Acc:S000005195]	termination of RNA polymerase II transcription, exosome-dependent	Nrd1 complex, nuclear exosome (RNase complex), nucleus	RNA binding, nucleic acid binding, nucleotide binding, transcription regulatory region RNA binding		
YNL252C	MRPL17	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000005196]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YNL253W	TEX1	Protein involved in mRNA export, component of the transcription export (TREX) complex [Source:SGD;Acc:S000005197]	mRNA export from nucleus	nucleus, transcription export complex	molecular_function, protein binding		
YNL254C	RTC4	Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000005198]	biological_process	cytoplasm, nucleus	molecular_function		
YNL255C	GIS2	Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 [Source:SGD;Acc:S000005199]	positive regulation of translation	cytoplasm, polysomal ribosome	mRNA binding, metal ion binding, nucleic acid binding, single-stranded DNA binding, translation regulator activity, zinc ion binding		
YNL256W	FOL1	Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities [Source:SGD;Acc:S000005200]	cellular metabolic process, folic acid biosynthetic process, folic acid-containing compound biosynthetic process, folic acid-containing compound metabolic process, pteridine-containing compound metabolic process, tetrahydrofolate biosynthetic process	cytoplasm, membrane, mitochondrial envelope, mitochondrial membrane, mitochondrion	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity, ATP binding, catalytic activity, dihydroneopterin aldolase activity, dihydropteroate synthase activity, kinase activity, lyase activity, metal ion binding, nucleotide binding, transferase activity		
YNL257C	SIP3	Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate [Source:SGD;Acc:S000005201]	positive regulation of transcription from RNA polymerase II promoter	cellular_component, integral to membrane, membrane	protein binding, transcription cofactor activity		
YNL258C	DSL1	Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p [Source:SGD;Acc:S000005202]	ER-dependent peroxisome organization, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	Dsl1p complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus, peroxisome	molecular_function		
YNL259C	ATX1	Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake [Source:SGD;Acc:S000005203]	cellular iron ion homeostasis, cellular response to oxidative stress, copper ion transport, ion transport, metal ion transport, transport	cytoplasm, cytosol	copper chaperone activity, metal ion binding		
YNL260C	YNL260C	Putative protein of unknown function with similarity to a human protein overexpressed in oral cancers; essential gene with defects in anaerobic and filamentous growth; localizes to the nucleus and cytoplasm [Source:SGD;Acc:S000005204]	biological_process	cytoplasm, nucleus	molecular_function		
YNL261W	ORC5	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing [Source:SGD;Acc:S000005205]	DNA replication, DNA-dependent DNA replication initiation, chromatin silencing at silent mating-type cassette, pre-replicative complex assembly, regulation of chromatin silencing at telomere	DNA replication preinitiation complex, nuclear origin of replication recognition complex, nucleus, origin recognition complex, pre-replicative complex	ATP binding, DNA replication origin binding, nucleotide binding		
YNL262W	POL2	Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p [Source:SGD;Acc:S000005206]	DNA replication, DNA replication involved in S phase, DNA synthesis involved in DNA repair, chromatin silencing at telomere, double-strand break repair via nonhomologous end joining, lagging strand elongation, leading strand elongation, mismatch repair, mitotic sister chromatid cohesion, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, nucleotide-excision repair	epsilon DNA polymerase complex, nucleus, replication fork	DNA binding, DNA-directed DNA polymerase activity, double-stranded DNA binding, metal ion binding, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, transferase activity, zinc ion binding		
YNL263C	YIF1	Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles [Source:SGD;Acc:S000005207]	ER to Golgi vesicle-mediated transport, protein transport, transport, vesicle-mediated transport	ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, integral to Golgi membrane, integral to membrane, membrane	molecular_function		
YNL264C	PDR17	Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition [Source:SGD;Acc:S000005208]	lipid transport, phospholipid biosynthetic process, phospholipid transport, response to drug, transport	cytoplasm, endosome	phosphatidylinositol transporter activity		
YNL265C	IST1	Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p [Source:SGD;Acc:S000005209]	late endosome to vacuole transport via multivesicular body sorting pathway, protein transport, transport	cytoplasm, endosome	molecular_function		
YNL266W	YNL266W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C [Source:SGD;Acc:S000005210]					
YNL267W	PIK1	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton [Source:SGD;Acc:S000005211]	phosphatidylinositol phosphorylation, phosphatidylinositol-mediated signaling	nucleus, trans-Golgi network	1-phosphatidylinositol 4-kinase activity, ATP binding, binding, inositol or phosphatidylinositol kinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity		
YNL268W	LYP1	Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids [Source:SGD;Acc:S000005212]	amino acid transport, basic amino acid transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrion, plasma membrane	amino acid transmembrane transporter activity, basic amino acid transmembrane transporter activity		
YNL269W	BSC4	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p [Source:SGD;Acc:S000005213]	biological_process	cellular_component	molecular_function		
YNL270C	ALP1	Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression [Source:SGD;Acc:S000005214]	amino acid transport, basic amino acid transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	amino acid transmembrane transporter activity, basic amino acid transmembrane transporter activity		
YNL271C	BNI1	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 [Source:SGD;Acc:S000005215]	actin cytoskeleton organization, actin filament bundle assembly involved in actomyosin contractile ring formation, actin nucleation, barbed-end actin filament capping, cellular component organization, establishment of mitotic spindle orientation, formin-nucleated actin cable assembly	actin filament, cell projection, cellular bud neck, cellular bud tip, cytoplasm, cytoskeleton, incipient cellular bud site, mating projection tip, membrane, plasma membrane, plasma membrane enriched fraction, polarisome, ruffle membrane	actin binding, binding, profilin binding		
YNL272C	SEC2	Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles [Source:SGD;Acc:S000005216]	autophagy, exocytosis, protein transport, transport	cellular bud neck, cellular bud tip, cytoplasmic vesicle, cytosol, mating projection tip, transport vesicle	guanyl-nucleotide exchange factor activity		
YNL273W	TOF1	Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase [Source:SGD;Acc:S000005217]	DNA repair, DNA replication, DNA replication checkpoint, cell cycle, maintenance of DNA repeat elements, meiosis, mitotic sister chromatid cohesion, negative regulation of DNA replication, replication fork arrest, replication fork protection, response to DNA damage stimulus	nuclear chromosome, nuclear replication fork, nucleus, replication fork protection complex	molecular_function		
YNL274C	GOR1	Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005218]	glyoxylate catabolic process, metabolic process, oxidation-reduction process	cytoplasm, mitochondrion, nucleus	NAD binding, binding, catalytic activity, cofactor binding, glyoxylate reductase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YNL275W	BOR1	Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 [Source:SGD;Acc:S000005219]	anion transport, borate transport, ion transport, protein targeting to vacuole, transport	fungal-type vacuole, integral to membrane, membrane, membrane fraction, plasma membrane, vacuolar membrane, vacuole	anion transmembrane transporter activity, anion:anion antiporter activity, borate binding, borate transmembrane transporter activity, inorganic anion exchanger activity		
YNL276C	YNL276C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W [Source:SGD;Acc:S000005220]					
YNL277W	MET2	L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway [Source:SGD;Acc:S000005221]	cellular amino acid biosynthetic process, homoserine metabolic process, methionine biosynthetic process	cytoplasm	O-acetyltransferase activity, acyltransferase activity, homoserine O-acetyltransferase activity, transferase activity		
YNL277W-A	YNL277W-A	Putative protein of unknown function [Source:SGD;Acc:S000028852]	biological_process	cellular_component	molecular_function		
YNL278W	CAF120	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation [Source:SGD;Acc:S000005222]	regulation of transcription from RNA polymerase II promoter	CCR4-NOT complex, cellular bud neck, cytoplasm, nucleus	molecular_function, protein binding		
YNL279W	PRM1	Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p [Source:SGD;Acc:S000005223]	conjugation, plasma membrane fusion involved in cytogamy, response to pheromone	integral to membrane, mating projection tip, membrane, plasma membrane	molecular_function		
YNL280C	ERG24	C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions [Source:SGD;Acc:S000005224]	ergosterol biosynthetic process, lipid biosynthetic process, oxidation-reduction process, steroid biosynthetic process, sterol biosynthetic process	endoplasmic reticulum, integral to membrane, membrane	delta14-sterol reductase activity, oxidoreductase activity		
YNL281W	HCH1	Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000005225]	protein folding, response to stress	cytoplasm, nucleus	ATPase activator activity, chaperone binding		
YNL282W	POP3	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends [Source:SGD;Acc:S000005226]	intronic box C/D snoRNA processing, mRNA cleavage, rRNA processing, tRNA processing	nucleolar ribonuclease P complex, nucleus, ribonuclease MRP complex	ribonuclease MRP activity, ribonuclease P activity		
YNL283C	WSC2	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response [Source:SGD;Acc:S000005227]	Rho protein signal transduction, actin cytoskeleton organization, cellular cell wall organization, fungal-type cell wall organization, response to heat	cellular bud, cytoplasm, integral to membrane, mating projection tip, membrane, membrane fraction, plasma membrane, site of polarized growth	transmembrane receptor activity		
YNL284C	MRPL10	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels [Source:SGD;Acc:S000005228]	mitochondrial translation, translation	large ribosomal subunit, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YNL284C-A	YNL284C-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007386]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YNL284C-B	YNL284C-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007387]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YNL285W	YNL285W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005229]					
YNL286W	CUS2	Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) [Source:SGD;Acc:S000005230]	nuclear mRNA splicing, via spliceosome	U2 snRNP	RNA binding, nucleic acid binding, nucleotide binding		
YNL287W	SEC21	Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo [Source:SGD;Acc:S000005231]	ER to Golgi vesicle-mediated transport, intracellular protein transport, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	COPI coated vesicle membrane, COPI vesicle coat, Golgi apparatus, Golgi membrane, Golgi-associated vesicle, cytoplasm, cytoplasmic vesicle, endosome, membrane, membrane coat	binding, molecular_function, structural molecule activity		
YNL288W	CAF40	Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p [Source:SGD;Acc:S000005232]	regulation of transcription from RNA polymerase II promoter	CCR4-NOT core complex, cytoplasm, nucleus	binding, molecular_function		
YNL289W	PCL1	Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth [Source:SGD;Acc:S000005233]	G1 phase of mitotic cell cycle, cell cycle, cell division, positive regulation of macroautophagy, regulation of cell division, regulation of cyclin-dependent protein kinase activity, regulation of establishment or maintenance of cell polarity, septin ring organization	cyclin-dependent protein kinase holoenzyme complex, cytoplasm, incipient cellular bud site, nucleus	cyclin-dependent protein kinase regulator activity, protein kinase binding		
YNL290W	RFC3	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [Source:SGD;Acc:S000005234]	DNA replication, cell cycle, leading strand elongation, mismatch repair, sister chromatid cohesion	Ctf18 RFC-like complex, DNA replication factor C complex, Elg1 RFC-like complex, Rad17 RFC-like complex, nucleus	ATP binding, ATPase activity, DNA binding, DNA clamp loader activity, nucleoside-triphosphatase activity, nucleotide binding		
YNL291C	MID1	N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer [Source:SGD;Acc:S000005235]	calcium ion transport, ion transport, transport	endoplasmic reticulum, integral to membrane, membrane, plasma membrane	calcium channel activity, ion channel activity, stretch-activated, cation-selective, calcium channel activity		
YNL292W	PUS4	Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) [Source:SGD;Acc:S000005236]	RNA modification, RNA processing, pseudouridine synthesis, tRNA modification, tRNA processing	mitochondrion, nucleus	RNA binding, isomerase activity, pseudouridine synthase activity		
YNL293W	MSB3	GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth [Source:SGD;Acc:S000005237]	actin filament organization, exocytosis, regulation of Rab GTPase activity	cellular bud, cellular bud neck, cellular bud tip, cytoplasm, incipient cellular bud site, intracellular, polarisome	GTPase activator activity, Rab GTPase activator activity		
YNL294C	RIM21	Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH [Source:SGD;Acc:S000005238]	ascospore formation, fungal-type cell wall biogenesis, invasive growth in response to glucose limitation	cellular_component, integral to membrane, membrane, plasma membrane	molecular_function		
YNL295W	YNL295W	Putative protein of unknown function [Source:SGD;Acc:S000005239]	biological_process	cellular_component	molecular_function		
YNL296W	YNL296W	Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog [Source:SGD;Acc:S000005240]					
YNL297C	MON2	Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins [Source:SGD;Acc:S000005241]	Golgi to endosome transport, endocytosis, protein targeting to vacuole, protein transport, transport	Golgi apparatus, Golgi membrane, cytosol, endosome, extrinsic to membrane, membrane, trans-Golgi network	binding, guanyl-nucleotide exchange factor activity		
YNL298W	CLA4	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p [Source:SGD;Acc:S000005242]	Rho protein signal transduction, budding cell apical bud growth, cytokinesis, establishment of cell polarity, negative regulation of gene expression, protein phosphorylation, regulation of exit from mitosis, response to pheromone, sterol import, vacuole inheritance	actin cap, cellular bud, fungal-type vacuole, nucleus	ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YNL299W	TRF5	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p [Source:SGD;Acc:S000005243]	DNA repair, U4 snRNA 3'-end processing, cell cycle, cell division, histone mRNA catabolic process, mitosis, ncRNA polyadenylation, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent snRNA catabolic process, nuclear polyadenylation-dependent snoRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, polyadenylation-dependent snoRNA 3'-end processing, response to DNA damage stimulus, snoRNA polyadenylation	TRAMP complex, nucleolus, nucleus	nucleotidyltransferase activity, polynucleotide adenylyltransferase activity, transferase activity		
YNL300W	TOS6	Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid [Source:SGD;Acc:S000005244]	biological_process	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YNL301C	RPL18B	Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein [Source:SGD;Acc:S000005245]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YNL302C	RPS19B	Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap [Source:SGD;Acc:S000005246]	rRNA export from nucleus, ribosomal small subunit biogenesis, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YNL303W	YNL303W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005247]					
YNL304W	YPT11	Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells [Source:SGD;Acc:S000005248]	Golgi inheritance, Golgi localization, endoplasmic reticulum inheritance, mitochondrion inheritance	cellular bud neck, cellular bud tip, endoplasmic reticulum, endoplasmic reticulum membrane, incipient cellular bud site, membrane	GTP binding, GTPase activity, nucleotide binding		
YNL305C	YNL305C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene [Source:SGD;Acc:S000005249]	biological_process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YNL306W	MRPS18	Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins [Source:SGD;Acc:S000005250]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YNL307C	MCK1	Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family [Source:SGD;Acc:S000005251]	ascospore formation, double-strand break repair via nonhomologous end joining, meiosis, mitotic sister chromatid segregation, protein phosphorylation, response to stress	soluble fraction	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, transferase activity		
YNL308C	KRI1	Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p [Source:SGD;Acc:S000005252]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus	molecular_function		
YNL309W	STB1	Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated [Source:SGD;Acc:S000005253]	G1/S transition of mitotic cell cycle	MBF transcription complex, SBF transcription complex, Sin3-type complex, cytoplasm, nucleus			
YNL310C	ZIM17	Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix [Source:SGD;Acc:S000005254]	mitochondrion organization, protein folding, protein import into mitochondrial matrix, protein stabilization, protein transport, response to unfolded protein, transport	membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion	chaperone binding, metal ion binding		
YNL311C	SKP2	F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000005255]	cellular protein catabolic process, regulation of sulfur amino acid metabolic process, ubiquitin-dependent protein catabolic process	ribosome, ubiquitin ligase complex	protein binding		
YNL312W	RFA2	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination [Source:SGD;Acc:S000005256]	DNA repair, DNA replication, DNA unwinding involved in replication, double-strand break repair via homologous recombination, establishment of protein localization, heteroduplex formation, mitotic recombination, nucleotide-excision repair, protein ubiquitination, reciprocal meiotic recombination, telomere maintenance via recombination, telomere maintenance via telomerase	DNA replication factor A complex, chromosome, telomeric region, condensed nuclear chromosome, nucleus	double-stranded DNA binding, nucleic acid binding, sequence-specific DNA binding, single-stranded DNA binding		
YNL313C	EMW1	Essential conserved protein with a role in maintaining cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1 [Source:SGD;Acc:S000005257]	fungal-type cell wall organization	cytoplasm, nucleus	binding, molecular_function, protein binding		
YNL314W	DAL82	Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain [Source:SGD;Acc:S000005258]	allantoin catabolic process, transcription initiation from RNA polymerase II promoter	nucleus	sequence-specific DNA binding		
YNL315C	ATP11	Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase [Source:SGD;Acc:S000005259]	mitochondrial proton-transporting ATP synthase complex assembly, mitochondrion organization, protein complex assembly	mitochondrial matrix, mitochondrion	unfolded protein binding		
YNL316C	PHA2	Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway [Source:SGD;Acc:S000005260]	L-phenylalanine biosynthetic process, aromatic amino acid family biosynthetic process, cellular amino acid biosynthetic process	cytoplasm	lyase activity, prephenate dehydratase activity		
YNL317W	PFS2	Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex [Source:SGD;Acc:S000005261]	mRNA cleavage, mRNA polyadenylation, mRNA processing	mRNA cleavage and polyadenylation specificity factor complex, nucleus	RNA binding, protein binding		
YNL318C	HXT14	Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005262]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrion, plasma membrane	galactose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YNL319W	YNL319W	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 [Source:SGD;Acc:S000005263]					
YNL320W	YNL320W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005264]	biological_process	integral to membrane, membrane, mitochondrion	molecular_function		
YNL321W	VNX1	Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate [Source:SGD;Acc:S000005265]	hydrogen transport, ion transport, potassium ion transport, sodium ion transport, transmembrane transport, transport	endoplasmic reticulum membrane, fungal-type vacuole, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	calcium:hydrogen antiporter activity, potassium:hydrogen antiporter activity, sodium:hydrogen antiporter activity		
YNL322C	KRE1	Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor [Source:SGD;Acc:S000005266]	cellular cell wall organization, fungal-type cell wall organization	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane, plasma membrane	structural constituent of cell wall		
YNL323W	LEM3	Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane [Source:SGD;Acc:S000005267]	cell surface receptor linked signaling pathway, phospholipid translocation	cytoplasm, endoplasmic reticulum, integral to membrane, membrane, plasma membrane	phospholipid-translocating ATPase activity		
YNL324W	YNL324W	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005268]					
YNL325C	FIG4	Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain [Source:SGD;Acc:S000005269]	phosphatidylinositol dephosphorylation	PAS complex, extrinsic to membrane, fungal-type vacuole membrane, membrane, vacuolar membrane, vacuole	hydrolase activity, phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity, phosphoric ester hydrolase activity		
YNL326C	PFA3	Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions [Source:SGD;Acc:S000005270]	protein palmitoylation, vacuole fusion, non-autophagic	fungal-type vacuole, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	acyltransferase activity, metal ion binding, protein-cysteine S-palmitoleyltransferase activity, transferase activity, zinc ion binding		
YNL327W	EGT2	Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner [Source:SGD;Acc:S000005271]	cell cycle, cell division, cytokinesis, mitosis	anchored to membrane, cell septum, cell wall, cellular bud, extracellular region, fungal-type cell wall, membrane	cellulase activity		
YNL328C	MDJ2	Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain [Source:SGD;Acc:S000005272]	protein import into mitochondrial matrix, protein transport, response to stress, transmembrane transport, transport	membrane, mitochondrial inner membrane, mitochondrion, presequence translocase-associated import motor	ATPase activator activity, heat shock protein binding, protein transporter activity		
YNL329C	PEX6	AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol [Source:SGD;Acc:S000005273]	peroxisome organization, protein import into peroxisome matrix, receptor recycling, replicative cell aging	cytoplasm, cytosol, membrane, membrane fraction, peroxisomal membrane, peroxisome, soluble fraction	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding, protein heterodimerization activity		
YNL330C	RPD3	Histone deacetylase; regulates transcription, silencing, and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members [Source:SGD;Acc:S000005274]	chromatin modification, histone H3 deacetylation, histone H4 deacetylation, histone deacetylation, negative regulation of chromatin silencing at rDNA, negative regulation of chromatin silencing at silent mating-type cassette, negative regulation of chromatin silencing at telomere, negative regulation of reciprocal meiotic recombination, negative regulation of transcription during meiosis, negative regulation of transcription from RNA polymerase I promoter, protein localization to nucleolar rDNA repeats, regulation of DNA-dependent DNA replication initiation, regulation of transcription by chromatin organization, regulation of transcription involved in G1/S phase of mitotic cell cycle, regulation of transcription involved in G2/M-phase of mitotic cell cycle, regulation of transcription involved in S phase of mitotic cell cycle, replicative cell aging, transcription elongation from RNA polymerase II promoter	Rpd3L complex, Rpd3L-Expanded complex, Rpd3S complex, Sin3-type complex, Snt2C complex, cytoplasm, histone deacetylase complex, nucleus	histone deacetylase activity, hydrolase activity, transcription coactivator activity, transcription corepressor activity		
YNL331C	AAD14	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role [Source:SGD;Acc:S000005275]	cellular aldehyde metabolic process, oxidation-reduction process	cellular_component	aryl-alcohol dehydrogenase activity, oxidoreductase activity		
YNL332W	THI12	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 [Source:SGD;Acc:S000005276]	thiamine biosynthetic process	cellular_component	molecular_function		
YNL333W	SNZ2	Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p [Source:SGD;Acc:S000005277]	metabolic process, pyridoxal phosphate biosynthetic process, pyridoxine biosynthetic process, pyridoxine metabolic process, thiamine biosynthetic process	cellular_component	catalytic activity, protein binding		
YNL334C	SNO2	Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin [Source:SGD;Acc:S000005278]	glutamine metabolic process, pyridoxine biosynthetic process, pyridoxine metabolic process, thiamine biosynthetic process	cellular_component	molecular_function, transferase activity		
YNL335W	DDI3	Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants [Source:SGD;Acc:S000005279]	biological_process	cellular_component	catalytic activity, lyase activity, molecular_function		
YNL336W	COS1	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000005280]	biological_process	fungal-type vacuole, integral to membrane, membrane	molecular_function		
YNL337W	YNL337W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005281]					
YNL338W	YNL338W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV [Source:SGD;Acc:S000005282]					
YNL339C	YRF1-6	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000005283]	telomere maintenance via recombination	nucleus	ATP binding, ATP-dependent helicase activity, DNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YNL339W-A	YNL339W-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028703]					
YNL339W-B	YNL339W-B	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028704]					
YNR001C	CIT1	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein [Source:SGD;Acc:S000005284]	acetyl-CoA catabolic process, cellular carbohydrate metabolic process, citrate metabolic process, glutamate biosynthetic process, tricarboxylic acid cycle	mitochondrial matrix, mitochondrion	citrate (Si)-synthase activity, transferase activity, transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer		
YNR001W-A	YNR001W-A	Dubious open reading frame unlikely to encode a functional protein; identified by homology [Source:SGD;Acc:S000007625]					
YNR002C	ATO2	Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p [Source:SGD;Acc:S000005285]	ammonium transport, ion transport, nitrogen utilization, transport	integral to membrane, membrane, mitochondrion, plasma membrane	ammonium transmembrane transporter activity		
YNR003C	RPC34	RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex [Source:SGD;Acc:S000005286]	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase III complex, cytoplasm, mitochondrion, nucleus	DNA binding, DNA-directed RNA polymerase activity		
YNR003W-A	YNR003W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene RPC34/YNR003C [Source:SGD;Acc:S000028705]					
YNR004W	SWM2	Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds [Source:SGD;Acc:S000005287]	biological_process	nucleolus	molecular_function		
YNR005C	YNR005C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005288]					
YNR006W	VPS27	Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) [Source:SGD;Acc:S000005289]	intracellular protein transport, late endosome to vacuole transport, protein retention in Golgi apparatus, protein targeting to vacuole	ESCRT-0 complex, endosome, endosome membrane, membrane	metal ion binding, phosphatidylinositol-3-phosphate binding, ubiquitin binding, zinc ion binding		
YNR007C	ATG3	E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt [Source:SGD;Acc:S000005290]	C-terminal protein lipidation, CVT pathway, autophagic vacuole assembly, autophagy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein transport, transport	cytoplasm, cytosol	Atg8 ligase activity		
YNR008W	LRO1	Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase [Source:SGD;Acc:S000005291]	lipid metabolic process, lipid storage, triglyceride biosynthetic process	endoplasmic reticulum, integral to membrane, membrane	acyltransferase activity, phosphatidylcholine-sterol O-acyltransferase activity, phospholipid:diacylglycerol acyltransferase activity, transferase activity		
YNR009W	NRM1	Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase [Source:SGD;Acc:S000005292]		cytoplasm, nucleus			
YNR010W	CSE2	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity [Source:SGD;Acc:S000005293]	mitotic sister chromatid segregation, transcription from RNA polymerase II promoter	mediator complex, nucleus			
YNR011C	PRP2	RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 [Source:SGD;Acc:S000005294]	RNA splicing, generation of catalytic spliceosome for first transesterification step, mRNA processing	U2-type catalytic step 1 spliceosome, nucleus	ATP binding, ATP-dependent helicase activity, RNA-dependent ATPase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YNR012W	URK1	Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP [Source:SGD;Acc:S000005295]	metabolic process, pyrimidine-containing compound salvage	cytoplasm, nucleus	ATP binding, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, transferase activity, uridine kinase activity		
YNR013C	PHO91	Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth [Source:SGD;Acc:S000005296]	phosphate transport, polyphosphate metabolic process, sodium ion transport, transmembrane transport, transport	integral to membrane, membrane, vacuolar membrane, vacuole	phosphate transmembrane transporter activity, transporter activity		
YNR014W	YNR014W	Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible [Source:SGD;Acc:S000005297]	biological_process	cytoplasm	molecular_function		
YNR015W	SMM1	Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs [Source:SGD;Acc:S000005298]	metabolic process, oxidation-reduction process, tRNA modification, tRNA processing	cytoplasm, nucleus	catalytic activity, flavin adenine dinucleotide binding, oxidoreductase activity, tRNA dihydrouridine synthase activity		
YNR016C	ACC1	Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids [Source:SGD;Acc:S000005299]	fatty acid biosynthetic process, lipid biosynthetic process, metabolic process, nuclear envelope organization, protein import into nucleus	cytoplasm, endoplasmic reticulum membrane, mitochondrion	ATP binding, acetyl-CoA carboxylase activity, biotin binding, biotin carboxylase activity, catalytic activity, ligase activity, metal ion binding, nucleotide binding		
YNR017W	TIM23	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel [Source:SGD;Acc:S000005300]	intracellular protein transport, protein import into mitochondrial matrix, protein transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial inner membrane presequence translocase complex, mitochondrion	P-P-bond-hydrolysis-driven protein transmembrane transporter activity, mitochondrion targeting sequence binding, protein channel activity, protein transporter activity		
YNR018W	AIM38	Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; may interact with respiratory chain complex IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000005301]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YNR019W	ARE2	Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen [Source:SGD;Acc:S000005302]	ergosterol metabolic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	O-acyltransferase activity, acyltransferase activity, cholesterol O-acyltransferase activity, ergosterol O-acyltransferase activity, lanosterol O-acyltransferase activity, transferase activity		
YNR020C	ATP23	Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex [Source:SGD;Acc:S000005303]	mitochondrial proton-transporting ATP synthase complex assembly, protein processing	membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion	hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity		
YNR021W	YNR021W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene [Source:SGD;Acc:S000005304]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YNR022C	MRPL50	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation [Source:SGD;Acc:S000005305]	mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YNR023W	SNF12	73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive [Source:SGD;Acc:S000005306]	chromatin remodeling, nucleosome mobilization	SWI/SNF complex, chromatin remodeling complex, nucleus	protein binding		
YNR024W	MPP6	Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes [Source:SGD;Acc:S000005307]	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nuclear mRNA surveillance of mRNA 3'-end processing, nuclear mRNA surveillance of spliceosomal pre-mRNA splicing, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, rRNA processing	TRAMP complex, nuclear exosome (RNase complex), nucleus, ribosome	RNA binding, poly(U) RNA binding		
YNR025C	YNR025C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase [Source:SGD;Acc:S000005308]					
YNR026C	SEC12	Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER [Source:SGD;Acc:S000005309]	protein transport, regulation of COPII vesicle coating, transport, vesicle-mediated transport	Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, integral to membrane of membrane fraction, membrane	GTPase activator activity, Sar guanyl-nucleotide exchange factor activity, protein binding		
YNR027W	BUD17	Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK) [Source:SGD;Acc:S000005310]	cell cycle, cellular bud site selection, pyridoxal phosphate biosynthetic process, pyridoxine biosynthetic process	cytoplasm, nucleus	ATP binding, kinase activity, metal ion binding, nucleotide binding, pyridoxal kinase activity, transferase activity		
YNR028W	CPR8	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway [Source:SGD;Acc:S000005311]	biological_process, protein folding	fungal-type vacuole	isomerase activity, peptidyl-prolyl cis-trans isomerase activity		
YNR029C	YNR029C	Putative protein of unknown function, deletion confers reduced fitness in saline [Source:SGD;Acc:S000005312]	biological_process	cytoplasm	ATP binding, molecular_function, nucleotide binding		
YNR030W	ALG12	Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation [Source:SGD;Acc:S000005313]	GPI anchor biosynthetic process, dolichol-linked oligosaccharide biosynthetic process, protein glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, intrinsic to endoplasmic reticulum membrane, membrane	alpha-1,6-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YNR031C	SSK2	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress [Source:SGD;Acc:S000005314]	MAPKKK cascade involved in osmosensory signaling pathway, actin cytoskeleton organization, osmosensory signaling pathway via two-component system, protein autophosphorylation, protein phosphorylation, response to osmotic stress	cellular bud neck, cellular bud tip, cytosol	ATP binding, MAP kinase kinase kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YNR032C-A	HUB1	Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear [Source:SGD;Acc:S000007251]	cell morphogenesis involved in conjugation with cellular fusion, nuclear mRNA splicing, via spliceosome, protein modification process	mating projection	protein binding, protein tag		
YNR032W	PPG1	Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases [Source:SGD;Acc:S000005315]	glycogen metabolic process, protein dephosphorylation	cytoplasm, nucleus	hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YNR033W	ABZ1	Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis [Source:SGD;Acc:S000005316]	biosynthetic process, folic acid biosynthetic process, glutamine metabolic process, metabolic process, para-aminobenzoic acid biosynthetic process	cytoplasm	4-amino-4-deoxychorismate synthase activity, anthranilate synthase activity, catalytic activity, oxo-acid-lyase activity, transferase activity		
YNR034W	SOL1	Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p [Source:SGD;Acc:S000005317]	carbohydrate metabolic process, pentose-phosphate shunt, tRNA export from nucleus	cytoplasm, nucleus	6-phosphogluconolactonase activity, molecular_function		
YNR034W-A	YNR034W-A	Putative protein of unknown function; expression is regulated by Msn2p/Msn4p [Source:SGD;Acc:S000007525]	biological_process	cytoplasm	molecular_function		
YNR035C	ARC35	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin [Source:SGD;Acc:S000005318]	actin cytoskeleton organization, microtubule cytoskeleton organization, mitochondrion inheritance, receptor-mediated endocytosis, regulation of actin filament polymerization	Arp2/3 protein complex, actin cortical patch, cytoplasm, cytoskeleton, cytosol	actin binding, structural molecule activity		
YNR036C	MRPS12	Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins [Source:SGD;Acc:S000005319]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome, small ribosomal subunit	structural constituent of ribosome		
YNR037C	RSM19	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein [Source:SGD;Acc:S000005320]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome, small ribosomal subunit	RNA binding, structural constituent of ribosome		
YNR038W	DBP6	Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family [Source:SGD;Acc:S000005321]	rRNA processing, ribosomal large subunit assembly, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YNR039C	ZRG17	Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc [Source:SGD;Acc:S000005322]	cation transport, transmembrane transport, zinc ion transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	cation transmembrane transporter activity, metal ion transmembrane transporter activity, zinc ion transmembrane transporter activity		
YNR040W	YNR040W	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005323]	biological_process	mitochondrion	molecular_function		
YNR041C	COQ2	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis [Source:SGD;Acc:S000005324]	biosynthetic process, isoprenoid biosynthetic process, ubiquinone biosynthetic process	integral to membrane, integral to mitochondrial membrane, membrane, microsome, mitochondrial inner membrane, mitochondrion	4-hydroxybenzoate octaprenyltransferase activity, prenyltransferase activity, transferase activity		
YNR042W	YNR042W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 [Source:SGD;Acc:S000005325]					
YNR043W	MVD1	Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer [Source:SGD;Acc:S000005326]	isoprenoid biosynthetic process, lipid biosynthetic process, phosphorylation, steroid biosynthetic process, sterol biosynthetic process	cytoplasm	ATP binding, diphosphomevalonate decarboxylase activity, kinase activity, lyase activity, nucleotide binding		
YNR044W	AGA1	Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds [Source:SGD;Acc:S000005327]	agglutination involved in conjugation with cellular fusion, cell adhesion, response to pheromone	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	cell adhesion molecule binding		
YNR045W	PET494	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane [Source:SGD;Acc:S000005328]	positive regulation of mitochondrial translation, regulation of translation	membrane, mitochondrial inner membrane, mitochondrion	translation regulator activity		
YNR046W	TRM112	Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin [Source:SGD;Acc:S000005329]	peptidyl-glutamine methylation, tRNA methylation	cytoplasm, eRF1 methyltransferase complex, nucleolus, nucleus, tRNA (m2G10) methyltransferase complex	protein methyltransferase activity, tRNA (guanine-N2-)-methyltransferase activity, zinc ion binding		
YNR047W	FPK1	Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane [Source:SGD;Acc:S000005330]	positive regulation of phospholipid translocation, protein autophosphorylation, protein phosphorylation, response to pheromone	cytoplasm, plasma membrane	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YNR048W	YNR048W	Protein that interacts specifically in vivo with phospholipid translocase (flippase) Dnf3p; similar to Cdc50p, which is an essential interaction partner of the flippase Drs2p [Source:SGD;Acc:S000005331]	response to drug	integral to membrane, membrane	phospholipid-translocating ATPase activity		
YNR049C	MSO1	Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation [Source:SGD;Acc:S000005332]	ascospore formation, ascospore-type prospore membrane assembly, cellular membrane fusion, protein transport, transport, vesicle docking involved in exocytosis	SNARE complex, cellular bud membrane, cellular bud neck, cellular bud tip, microsome, plasma membrane, prospore membrane	molecular_function		
YNR050C	LYS9	Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112 [Source:SGD;Acc:S000005333]	cellular amino acid biosynthetic process, lysine biosynthetic process, lysine biosynthetic process via aminoadipic acid, metabolic process, oxidation-reduction process	cytoplasm	binding, catalytic activity, oxidoreductase activity, saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity		
YNR051C	BRE5	Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A [Source:SGD;Acc:S000005334]	protein deubiquitination, regulation of ER to Golgi vesicle-mediated transport, regulation of retrograde vesicle-mediated transport, Golgi to ER, ribophagy, transport	cytoplasm, intracellular	RNA binding, molecular_function, nucleic acid binding		
YNR052C	POP2	RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation [Source:SGD;Acc:S000005335]	nuclear-transcribed mRNA poly(A) tail shortening, regulation of transcription from RNA polymerase II promoter, transcription elongation from RNA polymerase II promoter	CCR4-NOT core complex, cytoplasm, cytoplasmic mRNA processing body, mating projection tip, nucleus	3'-5'-exoribonuclease activity, RNA binding, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, poly(A)-specific ribonuclease activity		
YNR053C	NOG2	Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation [Source:SGD;Acc:S000005336]	ribosomal large subunit export from nucleus, ribosome biogenesis	intracellular, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor	GTP binding, GTPase activity, nucleotide binding		
YNR054C	ESF2	Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome [Source:SGD;Acc:S000005337]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis, small-subunit processome assembly	90S preribosome, cytoplasm, nucleolus, nucleus	ATPase activator activity, RNA binding, nucleotide binding		
YNR055C	HOL1	Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake [Source:SGD;Acc:S000005338]	cation transport, organic alcohol transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrion, plasma membrane	alcohol transmembrane transporter activity, inorganic cation transmembrane transporter activity		
YNR056C	BIO5	Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis [Source:SGD;Acc:S000005339]	amino acid transport, biotin biosynthetic process, transmembrane transport, transport, vitamin transport	integral to membrane, membrane, plasma membrane	amino acid transmembrane transporter activity, transmembrane transporter activity		
YNR057C	BIO4	Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels [Source:SGD;Acc:S000005340]	biotin biosynthetic process	cytoplasm	ATP binding, dethiobiotin synthase activity, ligase activity, magnesium ion binding, nucleotide binding		
YNR058W	BIO3	7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis [Source:SGD;Acc:S000005341]	biotin biosynthetic process	cytoplasm	adenosylmethionine-8-amino-7-oxononanoate transaminase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity		
YNR059W	MNT4	Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation [Source:SGD;Acc:S000005342]	protein O-linked glycosylation	cellular_component, integral to membrane, membrane	alpha-1,3-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YNR060W	FRE4	Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels [Source:SGD;Acc:S000005343]	electron transport chain, ion transport, iron ion transport, oxidation-reduction process, siderophore transport, transport	integral to membrane, membrane, plasma membrane	electron carrier activity, ferric-chelate reductase activity, flavin adenine dinucleotide binding, iron ion binding, metal ion binding, oxidoreductase activity		
YNR061C	YNR061C	Putative protein of unknown function [Source:SGD;Acc:S000005344]	biological_process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YNR062C	YNR062C	Putative membrane protein of unknown function [Source:SGD;Acc:S000005345]	biological_process	integral to membrane, membrane	molecular_function		
YNR063W	YNR063W	Putative zinc-cluster protein of unknown function [Source:SGD;Acc:S000005346]	biological_process, regulation of transcription, DNA-dependent	cellular_component, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YNR064C	YNR064C	Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides [Source:SGD;Acc:S000005347]	response to toxin	soluble fraction	carboxylesterase activity, epoxide hydrolase activity, hydrolase activity		
YNR065C	YNR065C	Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene [Source:SGD;Acc:S000005348]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YNR066C	YNR066C	Putative membrane-localized protein of unknown function [Source:SGD;Acc:S000005349]	biological_process	integral to membrane, membrane, membrane fraction	molecular_function		
YNR067C	DSE4	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother [Source:SGD;Acc:S000005350]	cell wall macromolecule catabolic process, cytokinesis, completion of separation, metabolic process	cell septum, cell wall, extracellular region, fungal-type cell wall	endo-1,3(4)-beta-glucanase activity, glucan endo-1,3-beta-D-glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds		
YNR068C	YNR068C	Putative protein of unknown function [Source:SGD;Acc:S000005351]	biological_process	cellular_component	molecular_function		
YNR069C	BSC5	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression [Source:SGD;Acc:S000005352]	biological_process	cellular_component	molecular_function		
YNR070W	PDR18	Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005353]	transport	integral to membrane, membrane, mitochondrion	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YNR071C	YNR071C	Putative protein of unknown function [Source:SGD;Acc:S000005354]	biological_process, carbohydrate metabolic process, hexose metabolic process	cellular_component	carbohydrate binding, catalytic activity, isomerase activity, molecular_function		
YNR072W	HXT17	Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose [Source:SGD;Acc:S000005355]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	fructose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YNR073C	YNR073C	Putative mannitol dehydrogenase [Source:SGD;Acc:S000005356]	biological_process, metabolic process, oxidation-reduction process	cellular_component	binding, catalytic activity, coenzyme binding, mannitol dehydrogenase activity, oxidoreductase activity		
YNR074C	AIF1	Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase [Source:SGD;Acc:S000005357]	apoptosis, oxidation-reduction process, positive regulation of apoptosis, response to singlet oxygen	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion, nucleus, plasma membrane	flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor		
YNR075C-A	YNR075C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028706]	biological_process	cellular_component	molecular_function		
YNR075W	COS10	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000005358]	endocytosis	cytoplasm, endoplasmic reticulum, integral to membrane, membrane, nuclear envelope	molecular_function		
YNR076W	PAU6	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme; identical to Pau18p [Source:SGD;Acc:S000005359]	biological_process, response to stress	cellular_component	molecular_function		
YNR077C	YNR077C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005360]					
YOL001W	PHO80	Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling [Source:SGD;Acc:S000005361]	cellular metal ion homeostasis, negative regulation of calcium-mediated signaling, negative regulation of macroautophagy, negative regulation of phosphate metabolic process, negative regulation of transcription from RNA polymerase II promoter, regulation of cyclin-dependent protein kinase activity, regulation of protein localization	cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus	cyclin-dependent protein kinase regulator activity		
YOL002C	IZH2	Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc [Source:SGD;Acc:S000005362]	cellular lipid metabolic process, cellular zinc ion homeostasis, fatty acid metabolic process, lipid metabolic process, response to toxin, response to zinc ion	integral to membrane, membrane, plasma membrane	metal ion binding, protein binding, receptor activity		
YOL003C	PFA4	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases [Source:SGD;Acc:S000005363]	protein palmitoylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	acyltransferase activity, metal ion binding, protein-cysteine S-palmitoleyltransferase activity, transferase activity, zinc ion binding		
YOL004W	SIN3	Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity [Source:SGD;Acc:S000005364]	cell cycle, cell division, chromatin modification, double-strand break repair via nonhomologous end joining, histone deacetylation, negative regulation of chromatin silencing at rDNA, negative regulation of chromatin silencing at silent mating-type cassette, negative regulation of chromatin silencing at telomere, negative regulation of transcription during meiosis, negative regulation of transcription from RNA polymerase I promoter, negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, regulation of DNA-dependent DNA replication initiation, regulation of transcription involved in G2/M-phase of mitotic cell cycle, regulation of transcription, DNA-dependent	Rpd3L complex, Rpd3L-Expanded complex, Rpd3S complex, Sin3-type complex, nucleus	transcription coactivator activity, transcription corepressor activity		
YOL005C	RPB11	RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit [Source:SGD;Acc:S000005365]	termination of RNA polymerase II transcription, transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex, nucleus	DNA binding, DNA-directed RNA polymerase activity, protein dimerization activity		
YOL006C	TOP1	Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination [Source:SGD;Acc:S000005366]	DNA strand elongation involved in DNA replication, DNA topological change, DNA unwinding involved in replication, chromatin assembly or disassembly, chromatin silencing at rDNA, mitotic chromosome condensation, nuclear migration, regulation of mitotic recombination, regulation of transcription from RNA polymerase II promoter, transcription elongation from RNA polymerase II promoter	chromosome, nucleolus, nucleoplasm, nucleus, replication fork protection complex	ATP binding, DNA binding, DNA topoisomerase (ATP-hydrolyzing) activity, DNA topoisomerase activity, DNA topoisomerase type I activity, isomerase activity, nucleotide binding		
YOL007C	CSI2	Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene [Source:SGD;Acc:S000005367]	biological_process	cellular bud neck, fungal-type vacuole	molecular_function		
YOL008W	COQ10	Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes [Source:SGD;Acc:S000005368]	cellular respiration	membrane, mitochondrial inner membrane, mitochondrion	ubiquinone binding		
YOL009C	MDM12	Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins [Source:SGD;Acc:S000005369]	mitochondrion inheritance, mitochondrion organization, phospholipid transport, protein import into mitochondrial outer membrane	ERMES complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YOL010W	RCL1	Subunit of U3-containing 90S preribosome processome complex involved in 18S rRNA biogenesis and small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no activity detected [Source:SGD;Acc:S000005370]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosome biogenesis	90S preribosome, nucleolus, nucleus	catalytic activity, enzyme activator activity		
YOL011W	PLB3	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro [Source:SGD;Acc:S000005371]	lipid catabolic process, metabolic process, phosphatidylinositol metabolic process, phosphatidylserine catabolic process, phospholipid catabolic process	anchored to membrane, extracellular region, membrane, plasma membrane	hydrolase activity, lysophospholipase activity, phospholipase activity		
YOL012C	HTZ1	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin [Source:SGD;Acc:S000005372]	chromatin modification, chromatin silencing at silent mating-type cassette, nuclear-transcribed mRNA catabolic process, non-stop decay, nucleosome assembly, regulation of transcription from RNA polymerase II promoter	chromatin assembly complex, chromosome, nuclear chromatin, nucleosome, nucleus	DNA binding, chromatin binding		
YOL013C	HRD1	Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger [Source:SGD;Acc:S000005373]	ER-associated protein catabolic process, fungal-type cell wall organization	Hrd1p ubiquitin ligase ERAD-L complex, Hrd1p ubiquitin ligase ERAD-M complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	ligase activity, metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YOL013W-A	YOL013W-A	Putative protein of unknown function; identified by SAGE [Source:SGD;Acc:S000028811]	biological_process	cellular_component	molecular_function		
YOL013W-B	YOL013W-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element [Source:SGD;Acc:S000007252]					
YOL014W	YOL014W	Putative protein of unknown function [Source:SGD;Acc:S000005374]	biological_process	cellular_component	molecular_function		
YOL015W	IRC10	Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000005375]	biological_process	cellular_component	molecular_function		
YOL016C	CMK2	Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II [Source:SGD;Acc:S000005376]	protein phosphorylation, signal transduction	cytoplasm	ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YOL017W	ESC8	Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex [Source:SGD;Acc:S000005377]	chromatin silencing	cytoplasm, nucleus	molecular_function		
YOL018C	TLG2	Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation [Source:SGD;Acc:S000005378]	CVT pathway, Golgi to vacuole transport, inositol phosphorylceramide metabolic process, intracellular protein transport, mannosyl-inositol phosphorylceramide metabolic process, protein exit from endoplasmic reticulum, protein transport, transport, vesicle fusion, vesicle-mediated transport	Golgi apparatus, Golgi trans cisterna, SNARE complex, early endosome, endosome, endosome membrane, integral to membrane, membrane, trans-Golgi network	SNAP receptor activity, protein binding		
YOL019W	YOL019W	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole [Source:SGD;Acc:S000005379]	biological_process	fungal-type vacuole, integral to membrane, membrane, plasma membrane, vacuolar membrane, vacuole	molecular_function		
YOL019W-A	YOL019W-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028707]	biological_process	cellular_component	molecular_function		
YOL020W	TAT2	High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance [Source:SGD;Acc:S000005380]	amino acid transport, aromatic amino acid transport, transmembrane transport, transport, tryptophan transport	integral to membrane, membrane, plasma membrane	amino acid transmembrane transporter activity, aromatic amino acid transmembrane transporter activity, catalytic activity, high-affinity tryptophan transmembrane transporter activity		
YOL021C	DIS3	Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3 [Source:SGD;Acc:S000005381]	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ncRNA 3'-end processing, nonfunctional rRNA decay, nuclear mRNA surveillance, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, non-stop decay, polyadenylation-dependent snoRNA 3'-end processing, rRNA catabolic process, rRNA processing	cytoplasm, cytoplasmic exosome (RNase complex), exosome (RNase complex), mitochondrion, nuclear exosome (RNase complex), nucleolus, nucleus	3'-5'-exoribonuclease activity, RNA binding, endoribonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, ribonuclease activity, tRNA binding		
YOL022C	TSR4	Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2 [Source:SGD;Acc:S000005382]	maturation of SSU-rRNA, rRNA processing	cytoplasm	molecular_function		
YOL023W	IFM1	Mitochondrial translation initiation factor 2 [Source:SGD;Acc:S000005383]	mitochondrial translation, mitochondrial translational initiation, translation, translational initiation	intracellular, mitochondrion	GTP binding, GTPase activity, nucleotide binding, tRNA binding, translation initiation factor activity		
YOL024W	YOL024W	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site [Source:SGD;Acc:S000005384]	biological_process	cellular_component	molecular_function		
YOL025W	LAG2	Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1 [Source:SGD;Acc:S000005385]	negative regulation of ubiquitin-protein ligase activity, replicative cell aging	mitochondrion	molecular_function		
YOL026C	MIM1	Mitochondrial outer membrane protein, required for assembly of the translocase of the outer membrane (TOM) complex and thereby for mitochondrial protein import; N terminus is exposed to the cytosol: transmembrane segment is highly conserved [Source:SGD;Acc:S000005386]	protein complex assembly, protein targeting to mitochondrion, protein transport, transport	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YOL027C	MDM38	Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome [Source:SGD;Acc:S000005387]	cellular potassium ion homeostasis, mitochondrion organization, potassium ion transport, protein insertion into mitochondrial membrane, proton transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YOL028C	YAP7	Putative basic leucine zipper (bZIP) transcription factor [Source:SGD;Acc:S000005388]	positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YOL029C	YOL029C	Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens [Source:SGD;Acc:S000005389]	biological_process	cellular_component	molecular_function		
YOL030W	GAS5	1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall [Source:SGD;Acc:S000005390]	biological_process, carbohydrate metabolic process, cellular cell wall organization	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane, membrane fraction	1,3-beta-glucanosyltransferase activity, catalytic activity, cation binding, transferase activity		
YOL031C	SIL1	Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein [Source:SGD;Acc:S000005391]	SRP-dependent cotranslational protein targeting to membrane, translocation, protein transport, transmembrane transport, transport	endoplasmic reticulum, endoplasmic reticulum lumen	adenyl-nucleotide exchange factor activity		
YOL032W	OPI10	Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline [Source:SGD;Acc:S000005392]	inositol metabolic process, phospholipid biosynthetic process	cytoplasm, nucleus	molecular_function		
YOL033W	MSE1	Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated [Source:SGD;Acc:S000005393]	glutamyl-tRNA aminoacylation, mitochondrial glutamyl-tRNA aminoacylation, mitochondrial translation, tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, RNA binding, aminoacyl-tRNA ligase activity, glutamate-tRNA ligase activity, ligase activity, ligase activity, forming aminoacyl-tRNA and related compounds, nucleotide binding		
YOL034W	SMC5	Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair [Source:SGD;Acc:S000005394]	DNA recombination, DNA repair, response to DNA damage stimulus	Smc5-Smc6 complex, chromosome, nucleus	ATP binding, molecular_function, nucleotide binding		
YOL035C	YOL035C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005395]					
YOL036W	YOL036W	Protein of unknown function; potential Cdc28p substrate [Source:SGD;Acc:S000005396]	biological_process	cellular_component	molecular_function		
YOL037C	YOL037C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W [Source:SGD;Acc:S000005397]					
YOL038C-A	YOL038C-A	Putative protein of unknown function; identified by SAGE analysis [Source:SGD;Acc:S000028812]	biological_process	cellular_component	molecular_function		
YOL038W	PRE6	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress [Source:SGD;Acc:S000005398]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteolysis involved in cellular protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, mitochondrion, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, molecular_function, peptidase activity, threonine-type endopeptidase activity		
YOL039W	RPP2A	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm [Source:SGD;Acc:S000005399]	translation, translational elongation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOL040C	RPS15	Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins [Source:SGD;Acc:S000005400]	rRNA export from nucleus, ribosome biogenesis, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome, small ribosomal subunit	RNA binding, structural constituent of ribosome		
YOL041C	NOP12	Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p [Source:SGD;Acc:S000005401]	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus, preribosome	RNA binding, nucleic acid binding, nucleotide binding		
YOL042W	NGL1	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005402]	biological_process	mitochondrion	endonuclease activity, exonuclease activity, hydrolase activity, nuclease activity		
YOL043C	NTG2	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus; sumoylated [Source:SGD;Acc:S000005403]	DNA repair, base-excision repair, base-excision repair, AP site formation, metabolic process, response to DNA damage stimulus	nucleus	4 iron, 4 sulfur cluster binding, DNA-(apurinic or apyrimidinic site) lyase activity, catalytic activity, endonuclease activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, iron-sulfur cluster binding, metal ion binding, oxidized pyrimidine base lesion DNA N-glycosylase activity		
YOL044W	PEX15	Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly [Source:SGD;Acc:S000005404]	peroxisome organization, protein import into peroxisome matrix, receptor recycling	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, integral to peroxisomal membrane, membrane, peroxisomal membrane, peroxisome, soluble fraction	protein anchor		
YOL045W	PSK2	One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation) [Source:SGD;Acc:S000005405]	negative regulation of glycogen biosynthetic process, protein phosphorylation, regulation of 1,6-beta-glucan biosynthetic process, signal transduction	cytoplasm, mitochondrion	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, signal transducer activity, transferase activity		
YOL046C	YOL046C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W [Source:SGD;Acc:S000005406]					
YOL047C	YOL047C	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000005407]	biological_process	cytoplasm, integral to membrane, membrane	molecular_function		
YOL048C	RRT8	Putative protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles [Source:SGD;Acc:S000005408]	biological_process	integral to membrane, lipid particle, membrane	molecular_function		
YOL049W	GSH2	Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock [Source:SGD;Acc:S000005409]	glutathione biosynthetic process	intracellular	ATP binding, catalytic activity, glutathione synthase activity, ligase activity, metal ion binding, nucleotide binding		
YOL050C	YOL050C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000005410]					
YOL051W	GAL11	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors [Source:SGD;Acc:S000005411]	regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus			
YOL052C	SPE2	S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically [Source:SGD;Acc:S000005412]	pantothenate biosynthetic process, polyamine biosynthetic process, spermidine biosynthetic process, spermine biosynthetic process	cytoplasm, nucleus	adenosylmethionine decarboxylase activity, carboxy-lyase activity, lyase activity		
YOL052C-A	DDR2	Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses [Source:SGD;Acc:S000005413]	response to stress	cytoplasm, fungal-type vacuole	molecular_function		
YOL053W	AIM39	Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000005414]	biological_process	cellular_component, integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YOL054W	PSH1	E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p [Source:SGD;Acc:S000005415]	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome, centromeric region, nucleus	metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YOL055C	THI20	Multifunctional protein with hydroxymethylpyrimidine phosphate (HMP-P) kinase and thiaminase activities; involved in thiamine biosynthesis and degradation; in a gene family with THI21 and THI22; HMP-P kinase activity redundant with Thi21p [Source:SGD;Acc:S000005416]	thiamine biosynthetic process, thiamine catabolic process	cytosol	ATP binding, hydroxymethylpyrimidine kinase activity, kinase activity, nucleotide binding, phosphomethylpyrimidine kinase activity, thiaminase activity, transferase activity		
YOL056W	GPM3	Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event [Source:SGD;Acc:S000005417]	biological_process, glycolysis, metabolic process	cytosol	catalytic activity, intramolecular transferase activity, phosphotransferases, isomerase activity, molecular_function, phosphoglycerate mutase activity		
YOL057W	YOL057W	Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers [Source:SGD;Acc:S000005418]	proteolysis	cytoplasm, nucleus	aminopeptidase activity, dipeptidyl-peptidase activity, hydrolase activity, metal ion binding, metallopeptidase activity, peptidase activity		
YOL058W	ARG1	Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate [Source:SGD;Acc:S000005419]	arginine biosynthetic process, argininosuccinate metabolic process, cellular amino acid biosynthetic process, citrulline metabolic process	cytosol	ATP binding, argininosuccinate synthase activity, ligase activity, nucleotide binding		
YOL059W	GPD2	NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria [Source:SGD;Acc:S000005420]	NADH oxidation, carbohydrate metabolic process, glycerol metabolic process, glycerol-3-phosphate catabolic process, glycerol-3-phosphate metabolic process, metabolic process, oxidation-reduction process	cytoplasm, cytosol, glycerol-3-phosphate dehydrogenase complex, mitochondrion	NAD binding, binding, catalytic activity, coenzyme binding, glycerol-3-phosphate dehydrogenase [NAD+] activity, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein homodimerization activity		
YOL060C	MAM3	Protein required for normal mitochondrial morphology, has similarity to hemolysins [Source:SGD;Acc:S000005421]	cellular manganese ion homeostasis, mitochondrion organization	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function, protein binding		
YOL061W	PRS5	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [Source:SGD;Acc:S000005422]	5-phosphoribose 1-diphosphate biosynthetic process, cellular biosynthetic process, fungal-type cell wall organization, nucleoside metabolic process, nucleotide biosynthetic process, ribonucleoside monophosphate biosynthetic process	cytoplasm	ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, ribose phosphate diphosphokinase activity, transferase activity		
YOL062C	APM4	Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport [Source:SGD;Acc:S000005423]	intracellular protein transport, transport, vesicle-mediated transport	AP-2 adaptor complex, clathrin adaptor complex, clathrin coated vesicle membrane, coated pit, cytoplasmic vesicle, membrane	molecular_function, protein binding		
YOL063C	CRT10	Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat [Source:SGD;Acc:S000005424]		cellular_component	molecular_function		
YOL064C	MET22	Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway [Source:SGD;Acc:S000005425]	hyperosmotic salinity response, methionine biosynthetic process, response to stress, sulfate assimilation, sulfur compound metabolic process	cellular_component	3'(2'),5'-bisphosphate nucleotidase activity, hydrolase activity, inositol or phosphatidylinositol phosphatase activity, metal ion binding		
YOL065C	INP54	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins [Source:SGD;Acc:S000005426]	phosphatidylinositol dephosphorylation, protein transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, membrane	hydrolase activity, inositol or phosphatidylinositol phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity		
YOL066C	RIB2	Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs [Source:SGD;Acc:S000005427]	RNA modification, pseudouridine synthesis, riboflavin biosynthetic process, tRNA processing, tRNA pseudouridine synthesis	cytoplasm	2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity, RNA binding, catalytic activity, diaminohydroxyphosphoribosylaminopyrimidine deaminase activity, hydrolase activity, isomerase activity, metal ion binding, pseudouridine synthase activity, zinc ion binding		
YOL067C	RTG1	Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus [Source:SGD;Acc:S000005428]	mitochondria-nucleus signaling pathway, protein localization, transcription initiation from RNA polymerase II promoter	cytoplasm, nucleus	DNA binding, transcription coactivator activity		
YOL068C	HST1	NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance [Source:SGD;Acc:S000005429]	chromatin modification, chromatin silencing, histone deacetylation, negative regulation of mitotic recombination, protein deacetylation, regulation of transcription, DNA-dependent, sporulation resulting in formation of a cellular spore	Set3 complex, nucleus	NAD binding, NAD+ binding, NAD-dependent histone deacetylase activity, NAD-independent histone deacetylase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, metal ion binding, zinc ion binding		
YOL069W	NUF2	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering [Source:SGD;Acc:S000005430]	cell cycle, cell division, chromosome segregation, microtubule nucleation, mitosis	Ndc80 complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, condensed nuclear chromosome, centromeric region, kinetochore, nucleus, spindle microtubule, spindle pole body	structural constituent of cytoskeleton		
YOL070C	NBA1	Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate [Source:SGD;Acc:S000005431]	biological_process	cellular bud neck, cytoplasm, ribosome	molecular_function		
YOL071W	EMI5	Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) [Source:SGD;Acc:S000005432]	ascospore formation, cellular respiration, meiosis, mitochondrial electron transport, succinate to ubiquinone, positive regulation of transcription from RNA polymerase II promoter, sporulation resulting in formation of a cellular spore, tricarboxylic acid cycle	mitochondrial matrix, mitochondrial respiratory chain complex II, mitochondrion	succinate dehydrogenase (ubiquinone) activity		
YOL072W	THP1	Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding [Source:SGD;Acc:S000005433]	cellular bud site selection, mRNA 3'-end processing, mRNA export from nucleus, mRNA transport, transcription elongation from RNA polymerase II promoter, transcription-coupled nucleotide-excision repair, transport	nuclear envelope, nuclear pore, nucleus, transcription export complex 2	RNA binding, double-stranded DNA binding		
YOL073C	YOL073C	Putative protein of unknown function [Source:SGD;Acc:S000005434]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOL075C	YOL075C	Putative ABC transporter [Source:SGD;Acc:S000005435]	transport	integral to membrane, membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YOL076W	MDM20	Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly [Source:SGD;Acc:S000005436]	N-terminal peptidyl-methionine acetylation, cytoskeleton organization, mitochondrion inheritance	NatB complex, cytoplasm	peptide alpha-N-acetyltransferase activity		
YOL077C	BRX1	Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif [Source:SGD;Acc:S000005437]	ribosomal large subunit assembly, ribosome biogenesis, translation	nucleolus, nucleus, preribosome, large subunit precursor	5S rRNA binding, ATP binding, aminoacyl-tRNA ligase activity, rRNA primary transcript binding		
YOL077W-A	ATP19	Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase [Source:SGD;Acc:S000007339]	ATP biosynthetic process, ATP synthesis coupled proton transport, ion transport, mitochondrial proton-transporting ATP synthase complex assembly, proton transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase complex, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrion, proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transporting ATP synthase activity, rotational mechanism		
YOL078W	AVO1	Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth [Source:SGD;Acc:S000005438]	TOR signaling cascade, establishment or maintenance of actin cytoskeleton polarity, fungal-type cell wall organization, negative regulation of Ras protein signal transduction, regulation of cell growth	TORC2 complex, cytoplasm, membrane, plasma membrane, vacuolar membrane, vacuole	Ras GTPase binding, phosphatidylinositol-4,5-bisphosphate binding		
YOL079W	YOL079W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005439]					
YOL080C	REX4	Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly [Source:SGD;Acc:S000005440]	rRNA processing, ribosomal large subunit assembly	intracellular, nucleolus, nucleus	3'-5' exonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding		
YOL081W	IRA2	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin [Source:SGD;Acc:S000005441]	negative regulation of Ras protein signal transduction, negative regulation of cAMP biosynthetic process, positive regulation of Ras GTPase activity, regulation of small GTPase mediated signal transduction, response to stress, signal transduction	cytoplasm, intracellular, mitochondrion	GTPase activator activity, Ras GTPase activator activity		
YOL082W	ATG19	Receptor protein specific for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles [Source:SGD;Acc:S000005442]	CVT pathway, ER-associated protein catabolic process, autophagy, protein complex localization, protein maturation by peptide bond cleavage, protein transport, transport, vesicle organization	CVT complex, cytoplasm, membrane, peripheral to membrane of membrane fraction, pre-autophagosomal structure, pre-autophagosomal structure membrane	protein binding, bridging		
YOL083C-A	YOL083C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028853]					
YOL083W	ATG34	Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog [Source:SGD;Acc:S000005443]	autophagy, protein complex assembly, protein complex localization, protein transport, transport	CVT complex, membrane, pre-autophagosomal structure membrane	protein binding, bridging		
YOL084W	PHM7	Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole [Source:SGD;Acc:S000005444]	biological_process	fungal-type vacuole, integral to membrane, membrane, plasma membrane	molecular_function		
YOL085C	YOL085C	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A [Source:SGD;Acc:S000005445]					
YOL085W-A	YOL085W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C [Source:SGD;Acc:S000028708]					
YOL086C	ADH1	Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway [Source:SGD;Acc:S000005446]	NADH oxidation, amino acid catabolic process to alcohol via Ehrlich pathway, ethanol biosynthetic process involved in glucose fermentation to ethanol, fermentation, metabolic process, oxidation-reduction process	cytoplasm, cytosol, plasma membrane enriched fraction	alcohol dehydrogenase (NAD) activity, binding, catalytic activity, metal ion binding, methylglyoxal reductase (NADH-dependent) activity, oxidoreductase activity, zinc ion binding		
YOL086W-A	YOL086W-A	Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF1, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability [Source:SGD;Acc:S000007626]	response to DNA damage stimulus	cellular_component	DNA binding, molecular_function		
YOL087C	YOL087C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid [Source:SGD;Acc:S000005447]	biological_process	cytoplasm	protein binding, ubiquitin binding		
YOL088C	MPD2	Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p [Source:SGD;Acc:S000005448]	cell redox homeostasis, protein folding	endoplasmic reticulum	isomerase activity, protein disulfide isomerase activity, protein disulfide oxidoreductase activity		
YOL089C	HAL9	Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression [Source:SGD;Acc:S000005449]	regulation of transcription, DNA-dependent, response to salt stress, transcription initiation from RNA polymerase II promoter	cytoplasm, mitochondrion, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YOL090W	MSH2	Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP [Source:SGD;Acc:S000005450]	DNA recombination, DNA repair, chromatin silencing at silent mating-type cassette, meiotic gene conversion, meiotic mismatch repair, mismatch repair, mitotic recombination, removal of nonhomologous ends, response to DNA damage stimulus	MutSalpha complex, MutSbeta complex, nuclear chromosome, nucleus	ATP binding, ATPase activity, DNA binding, DNA insertion or deletion binding, Y-form DNA binding, double-strand/single-strand DNA junction binding, four-way junction DNA binding, guanine/thymine mispair binding, loop DNA binding, mismatched DNA binding, nucleotide binding, single base insertion or deletion binding		
YOL091W	SPO21	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation [Source:SGD;Acc:S000005451]	ascospore wall assembly, cell cycle, cell division, meiosis, sporulation resulting in formation of a cellular spore	cytoplasm, cytoskeleton, membrane, prospore membrane, spindle pole, spindle pole body	structural molecule activity		
YOL092W	YOL092W	Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W [Source:SGD;Acc:S000005452]	biological_process	cytoplasm, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YOL093W	TRM10	tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs [Source:SGD;Acc:S000005453]	tRNA methylation, tRNA processing	cytoplasm, nucleus	methyltransferase activity, tRNA (guanine) methyltransferase activity, tRNA (guanine-N1-)-methyltransferase activity, transferase activity		
YOL094C	RFC4	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [Source:SGD;Acc:S000005454]	DNA replication, cell cycle, leading strand elongation, mismatch repair, sister chromatid cohesion	Ctf18 RFC-like complex, DNA replication factor C complex, Elg1 RFC-like complex, Rad17 RFC-like complex, nucleus	ATP binding, DNA binding, DNA clamp loader activity, nucleoside-triphosphatase activity, nucleotide binding, purine nucleotide binding		
YOL095C	HMI1	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD [Source:SGD;Acc:S000005455]	DNA repair, mitochondrial DNA metabolic process, mitochondrial genome maintenance, response to DNA damage stimulus	membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion	ATP binding, ATP-dependent 3'-5' DNA helicase activity, ATP-dependent DNA helicase activity, DNA binding, helicase activity, hydrolase activity, nucleotide binding		
YOL096C	COQ3	O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein [Source:SGD;Acc:S000005456]	metabolic process, ubiquinone biosynthetic process	extrinsic to membrane, membrane, mitochondrial inner membrane, mitochondrion	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity, hexaprenyldihydroxybenzoate methyltransferase activity, methyltransferase activity, transferase activity		
YOL097C	WRS1	Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA [Source:SGD;Acc:S000005457]	tRNA aminoacylation for protein translation, translation, tryptophanyl-tRNA aminoacylation	cytoplasm	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, tryptophan-tRNA ligase activity		
YOL097W-A	YOL097W-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028854]	biological_process	cellular_component	molecular_function		
YOL098C	YOL098C	Putative metalloprotease [Source:SGD;Acc:S000005458]	biological_process, proteolysis	cytoplasm	catalytic activity, metal ion binding, metalloendopeptidase activity, molecular_function, zinc ion binding		
YOL099C	YOL099C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes [Source:SGD;Acc:S000005459]					
YOL100W	PKH2	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p [Source:SGD;Acc:S000005460]	MAPKKK cascade involved in cell wall biogenesis, cytoplasmic mRNA processing body assembly, protein phosphorylation, regulation of nuclear-transcribed mRNA poly(A) tail shortening	cell cortex, nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YOL101C	IZH4	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism [Source:SGD;Acc:S000005461]	cellular lipid metabolic process, cellular zinc ion homeostasis	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	metal ion binding		
YOL102C	TPT1	tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide [Source:SGD;Acc:S000005462]	tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation	nucleus	tRNA 2'-phosphotransferase activity, transferase activity, transferase activity, transferring phosphorus-containing groups		
YOL103W	ITR2	Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively [Source:SGD;Acc:S000005463]	myo-inositol transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	myo-inositol transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YOL103W-A	YOL103W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007349]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YOL103W-B	YOL103W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007350]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YOL104C	NDJ1	Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement [Source:SGD;Acc:S000005464]	attachment of telomeres to nuclear envelope, meiosis, meiotic telomere clustering, reciprocal meiotic recombination, regulation of reciprocal meiotic recombination, synapsis	chromosome, telomeric region, nuclear chromosome, telomeric region, nucleus	telomeric DNA binding		
YOL105C	WSC3	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis [Source:SGD;Acc:S000005465]	Rho protein signal transduction, actin cytoskeleton organization, cellular cell wall organization, fungal-type cell wall organization, peroxisome degradation, response to heat	integral to membrane, mating projection tip, membrane, membrane fraction	transmembrane receptor activity		
YOL106W	YOL106W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005466]					
YOL107W	YOL107W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein [Source:SGD;Acc:S000005467]	biological_process	COPI-coated vesicle, Golgi apparatus, Golgi membrane, integral to membrane, membrane	molecular_function		
YOL108C	INO4	Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain [Source:SGD;Acc:S000005468]	phospholipid biosynthetic process, positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding		
YOL109W	ZEO1	Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria [Source:SGD;Acc:S000005469]	fungal-type cell wall organization, response to stress	extrinsic to plasma membrane, membrane, mitochondrial outer membrane, mitochondrion, plasma membrane, plasma membrane enriched fraction	molecular_function		
YOL110W	SHR5	Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization [Source:SGD;Acc:S000005470]	protein palmitoylation, protein targeting to membrane	endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum palmitoyltransferase complex, extrinsic to endoplasmic reticulum membrane, membrane	protein-cysteine S-palmitoleyltransferase activity		
YOL111C	MDY2	Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes [Source:SGD;Acc:S000005471]	cell morphogenesis involved in conjugation with cellular fusion, posttranslational protein targeting to membrane, protein insertion into ER membrane	TRC complex, cytoplasm, cytosol, nucleus, ribosome	molecular_function, protein binding		
YOL112W	MSB4	GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization [Source:SGD;Acc:S000005472]	actin filament organization, regulation of Rab GTPase activity	cellular bud, cellular bud neck, cellular bud tip, cytoplasm, incipient cellular bud site, intracellular, polarisome	GTPase activator activity, Rab GTPase activator activity		
YOL113W	SKM1	Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth [Source:SGD;Acc:S000005473]	cytokinetic cell separation, negative regulation of gene expression, protein phosphorylation, regulation of cell cycle, sterol import	nucleus, plasma membrane	ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YOL114C	YOL114C	Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene [Source:SGD;Acc:S000005474]	biological_process, translational termination	cellular_component	molecular_function, translation release factor activity		
YOL115W	PAP2	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p [Source:SGD;Acc:S000005475]	U4 snRNA 3'-end processing, base-excision repair, cell cycle, cell division, histone mRNA catabolic process, mitosis, ncRNA polyadenylation, nuclear mRNA surveillance of mRNA 3'-end processing, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent antisense transcript catabolic process, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent snRNA catabolic process, nuclear polyadenylation-dependent snoRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, polyadenylation-dependent mRNA catabolic process, polyadenylation-dependent snoRNA 3'-end processing, snoRNA polyadenylation	TRAMP complex, nucleolus, nucleus	5'-deoxyribose-5-phosphate lyase activity, nucleotidyltransferase activity, polynucleotide adenylyltransferase activity, transferase activity		
YOL116W	MSN1	Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus [Source:SGD;Acc:S000005476]	hyperosmotic response, invasive growth in response to glucose limitation	nucleus	DNA binding		
YOL117W	RRI2	Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response [Source:SGD;Acc:S000005477]	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, cullin deneddylation	cytoplasm, nucleus, signalosome	molecular_function		
YOL118C	YOL118C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005478]					
YOL119C	MCH4	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport [Source:SGD;Acc:S000005479]	transmembrane transport, transport	fungal-type vacuole membrane, integral to membrane, membrane	symporter activity, transporter activity		
YOL120C	RPL18A	Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation [Source:SGD;Acc:S000005480]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOL121C	RPS19A	Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp [Source:SGD;Acc:S000005481]	rRNA export from nucleus, ribosomal small subunit biogenesis, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOL122C	SMF1	Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins [Source:SGD;Acc:S000005482]	cadmium ion transport, cellular cadmium ion homeostasis, cellular copper ion homeostasis, cellular manganese ion homeostasis, copper ion transport, iron ion transport, manganese ion transport, transport	integral to membrane, membrane, plasma membrane	inorganic cation transmembrane transporter activity, metal ion binding, solute:hydrogen symporter activity, transporter activity		
YOL123W	HRP1	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences [Source:SGD;Acc:S000005483]	mRNA cleavage, mRNA polyadenylation, mRNA processing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm, mRNA cleavage factor complex, nucleus, stress granule	RNA binding, mRNA binding, nucleic acid binding, nucleotide binding		
YOL124C	TRM11	Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain [Source:SGD;Acc:S000005484]	methylation, tRNA methylation, tRNA processing	cytoplasm, tRNA (m2G10) methyltransferase complex	RNA binding, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, nucleic acid binding, tRNA (guanine-N2-)-methyltransferase activity, transferase activity		
YOL125W	TRM13	2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases [Source:SGD;Acc:S000005485]	tRNA methylation, tRNA processing	cytoplasm, nucleus	metal ion binding, methyltransferase activity, tRNA methyltransferase activity, transferase activity		
YOL126C	MDH2	Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1 [Source:SGD;Acc:S000005486]	carbohydrate metabolic process, cellular carbohydrate metabolic process, gluconeogenesis, glycolysis, malate metabolic process, metabolic process, oxidation-reduction process, protein import into peroxisome matrix, tricarboxylic acid cycle	cytoplasm, cytosol	L-malate dehydrogenase activity, binding, catalytic activity, malate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YOL127W	RPL25	Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif [Source:SGD;Acc:S000005487]	ribosomal large subunit assembly, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, nucleotide binding, rRNA binding, structural constituent of ribosome		
YOL128C	YGK3	Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation [Source:SGD;Acc:S000005488]	protein phosphorylation, proteolysis, response to stress	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YOL129W	VPS68	Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria [Source:SGD;Acc:S000005489]	late endosome to vacuole transport via multivesicular body sorting pathway, protein targeting to vacuole, protein transport, transport	Vps55/Vps68 complex, fungal-type vacuole membrane, integral to membrane, membrane, mitochondrion, vacuolar membrane, vacuole	molecular_function		
YOL130W	ALR1	Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions [Source:SGD;Acc:S000005490]	cation transport, magnesium ion transport, metal ion transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	inorganic cation transmembrane transporter activity, metal ion transmembrane transporter activity		
YOL131W	YOL131W	Putative protein of unknown function [Source:SGD;Acc:S000005491]	biological_process	cellular_component	molecular_function		
YOL132W	GAS4	1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall [Source:SGD;Acc:S000005492]	ascospore wall assembly, carbohydrate metabolic process, cellular cell wall organization	anchored to membrane, fungal-type cell wall, membrane, plasma membrane	1,3-beta-glucanosyltransferase activity, catalytic activity, cation binding, transferase activity		
YOL133W	HRT1	RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF [Source:SGD;Acc:S000005493]	G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination involved in ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex, cytoplasm, nucleus	metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YOL134C	YOL134C	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit [Source:SGD;Acc:S000005494]					
YOL135C	MED7	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000005495]	regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus			
YOL136C	PFK27	6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A [Source:SGD;Acc:S000005496]	fructose 2,6-bisphosphate metabolic process, fructose metabolic process, regulation of glycolysis	cytoplasm	6-phosphofructo-2-kinase activity, ATP binding, catalytic activity, kinase activity, nucleotide binding, transferase activity		
YOL137W	BSC6	Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression [Source:SGD;Acc:S000005497]	biological_process, transmembrane transport, transport	COPI-coated vesicle, Golgi apparatus, clathrin-coated vesicle, integral to membrane, membrane	molecular_function		
YOL138C	RTC1	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; null mutation suppresses cdc13-1 temperature sensitivity [Source:SGD;Acc:S000005498]	biological_process	fungal-type vacuole, ribosome, vacuole	metal ion binding, molecular_function, zinc ion binding		
YOL139C	CDC33	Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p) [Source:SGD;Acc:S000005499]	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of cell cycle, regulation of translation, translation, translational initiation	cytoplasm, eukaryotic translation initiation factor 4F complex, nucleus, ribosome, stress granule	RNA binding, phosphatidylinositol-3-phosphate binding, translation initiation factor activity		
YOL140W	ARG8	Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine [Source:SGD;Acc:S000005500]	arginine biosynthetic process, arginine metabolic process, cellular amino acid biosynthetic process, ornithine biosynthetic process	mitochondrial matrix, mitochondrion	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity		
YOL141W	PPM2	AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p [Source:SGD;Acc:S000005501]	tRNA methylation, tRNA processing, wybutosine biosynthetic process	cytoplasm, mitochondrion	methyltransferase activity, tRNA methyltransferase activity, transferase activity		
YOL142W	RRP40	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p (EXOSC3) [Source:SGD;Acc:S000005502]	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ncRNA 3'-end processing, nonfunctional rRNA decay, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, polyadenylation-dependent snoRNA 3'-end processing, rRNA processing	cytoplasm, cytoplasmic exosome (RNase complex), exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleus	RNA binding, manganese ion binding		
YOL143C	RIB4	Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin [Source:SGD;Acc:S000005503]	riboflavin biosynthetic process	cytoplasm, nucleus, riboflavin synthase complex	6,7-dimethyl-8-ribityllumazine synthase activity, riboflavin synthase activity, transferase activity		
YOL144W	NOP8	Nucleolar protein required for 60S ribosomal subunit biogenesis [Source:SGD;Acc:S000005504]	ribosomal large subunit biogenesis, ribosome biogenesis	nucleolus, nucleus	RNA binding, molecular_function, nucleic acid binding, nucleotide binding		
YOL145C	CTR9	Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; contains TPR repeats [Source:SGD;Acc:S000005505]	chromosome segregation, histone methylation, transcription elongation from RNA polymerase I promoter, transcription elongation from RNA polymerase II promoter, transcription from RNA polymerase II promoter	Cdc73/Paf1 complex, nucleoplasm, nucleus, transcription elongation factor complex	DNA binding, binding, triplex DNA binding		
YOL146W	PSF3	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery [Source:SGD;Acc:S000005506]	DNA replication, DNA-dependent DNA replication, double-strand break repair via break-induced replication	DNA replication preinitiation complex, GINS complex, nucleus, replication fork protection complex	molecular_function		
YOL147C	PEX11	Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p [Source:SGD;Acc:S000005507]	fatty acid oxidation, peroxisome fission, peroxisome organization	endoplasmic reticulum, membrane, peroxisomal membrane, peroxisome	molecular_function		
YOL148C	SPT20	Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex [Source:SGD;Acc:S000005508]	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response, chromatin modification, histone acetylation	SAGA complex, SLIK (SAGA-like) complex, nucleus	transcription cofactor activity		
YOL149W	DCP1	Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p [Source:SGD;Acc:S000005509]	deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA processing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm, cytoplasmic mRNA processing body	RNA binding, enzyme activator activity, m7G(5')pppN diphosphatase activity, mRNA binding		
YOL150C	YOL150C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005510]					
YOL151W	GRE2	3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway [Source:SGD;Acc:S000005511]	cellular metabolic process, ergosterol metabolic process, filamentous growth, metabolic process, oxidation-reduction process	cytoplasm, nucleus	3-methylbutanol:NAD(P) oxidoreductase activity, binding, catalytic activity, coenzyme binding, methylglyoxal reductase (NADPH-dependent) activity, oxidoreductase activity		
YOL152W	FRE7	Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels [Source:SGD;Acc:S000005512]	copper ion import, copper ion transport, electron transport chain, ion transport, iron ion transport, oxidation-reduction process, transport	integral to membrane, membrane, plasma membrane	electron carrier activity, ferric-chelate reductase activity, flavin adenine dinucleotide binding, iron ion binding, metal ion binding, oxidoreductase activity		
YOL154W	ZPS1	Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH [Source:SGD;Acc:S000005514]	biological_process	fungal-type cell wall, fungal-type vacuole	molecular_function		
YOL155C	HPF1	Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines [Source:SGD;Acc:S000005515]	cellular cell wall organization, fungal-type cell wall organization	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	glucosidase activity		
YOL155W-A	YOL155W-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028855]	biological_process	cellular_component	molecular_function		
YOL156W	HXT11	Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance [Source:SGD;Acc:S000005516]	carbohydrate transport, hexose transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	fructose transmembrane transporter activity, galactose transmembrane transporter activity, glucose transmembrane transporter activity, mannose transmembrane transporter activity, substrate-specific transmembrane transporter activity, transporter activity		
YOL157C	IMA2	Alpha-glucosidase with specificity for isomaltase, methyl-alpha-glucoside, and palatinose; member of IMA isomaltase family; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose [Source:SGD;Acc:S000005517]	carbohydrate metabolic process, disaccharide catabolic process, maltose metabolic process, metabolic process	cellular_component	alpha-glucosidase activity, catalytic activity, cation binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, oligo-1,6-glucosidase activity		
YOL158C	ENB1	Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment [Source:SGD;Acc:S000005518]	ferric-enterobactin transport, ion transport, iron ion transport, transmembrane transport, transport	cellular bud membrane, endosome, endosome membrane, integral to membrane, membrane, plasma membrane	ferric-enterobactin transmembrane transporter activity		
YOL159C	YOL159C	Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA [Source:SGD;Acc:S000005519]	biological_process	cytoplasm, soluble fraction	molecular_function		
YOL159C-A	YOL159C-A	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000007627]	biological_process	cytoplasm	molecular_function		
YOL160W	YOL160W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005520]					
YOL161C	PAU20	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression induced by low temperature and also by anaerobic conditions; induced during alcoholic fermentation [Source:SGD;Acc:S000005521]	biological_process, response to stress	cellular_component, integral to membrane, membrane	molecular_function		
YOL162W	YOL162W	Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family [Source:SGD;Acc:S000005522]	transmembrane transport, transport	integral to membrane, membrane	transmembrane transporter activity		
YOL163W	YOL163W	Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family [Source:SGD;Acc:S000005523]	transmembrane transport, transport	integral to membrane, membrane	transmembrane transporter activity		
YOL164W	BDS1	Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources [Source:SGD;Acc:S000005524]	dodecyl sulfate metabolic process	cellular_component	alkyl sulfatase activity, arylsulfatase activity, hydrolase activity, sterol binding		
YOL164W-A	YOL164W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028580]	biological_process	cellular_component	molecular_function		
YOL165C	AAD15	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role [Source:SGD;Acc:S000005525]	cellular aldehyde metabolic process, oxidation-reduction process	cellular_component	aryl-alcohol dehydrogenase activity, oxidoreductase activity		
YOL166C	YOL166C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005526]					
YOL166W-A	YOL166W-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028709]	biological_process	cellular_component	molecular_function		
YOR001W	RRP6	Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10) [Source:SGD;Acc:S000005527]	RNA processing, U1 snRNA 3'-end processing, U4 snRNA 3'-end processing, U5 snRNA 3'-end processing, cellular metabolic process, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), histone mRNA catabolic process, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent antisense transcript catabolic process, nuclear polyadenylation-dependent mRNA catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent snRNA catabolic process, nuclear polyadenylation-dependent snoRNA catabolic process, nuclear polyadenylation-dependent tRNA catabolic process, nuclear retention of pre-mRNA at the site of transcription, nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, polyadenylation-dependent snoRNA 3'-end processing, posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery, rRNA processing	exosome (RNase complex), intracellular, nuclear exosome (RNase complex), nucleolus, nucleus	3'-5' exonuclease activity, 3'-5'-exoribonuclease activity, RNA binding, catalytic activity, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, nucleotide binding		
YOR002W	ALG6	Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease [Source:SGD;Acc:S000005528]	aerobic respiration, oligosaccharide-lipid intermediate biosynthetic process, protein glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups		
YOR003W	YSP3	Putative precursor to the subtilisin-like protease III [Source:SGD;Acc:S000005529]	negative regulation of catalytic activity, protein catabolic process, proteolysis	cellular_component	hydrolase activity, identical protein binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity		
YOR004W	UTP23	Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function [Source:SGD;Acc:S000005530]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	mitochondrion, nucleolus, nucleus, small-subunit processome	RNA binding, molecular_function		
YOR005C	DNL4	DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth [Source:SGD;Acc:S000005531]	DNA ligation involved in DNA repair, DNA recombination, DNA repair, DNA replication, cell cycle, cell division, double-strand break repair via nonhomologous end joining, replicative cell aging, response to DNA damage stimulus	DNA ligase IV complex, intracellular, nuclear chromatin, nucleus	ATP binding, DNA binding, DNA ligase (ATP) activity, DNA ligase activity, ligase activity, metal ion binding, nucleotide binding		
YOR006C	TSR3	Protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000005532]	maturation of SSU-rRNA	cytoplasm, nucleus	molecular_function		
YOR007C	SGT2	Glutamine-rich cytoplasmic protein that serves as a scaffold for binding Get4/5p and other proteins required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; has similarity to human cochaperone SGT [Source:SGD;Acc:S000005533]	posttranslational protein targeting to membrane, response to heat	TRC complex, cytoplasm	binding, molecular_function, protein binding		
YOR008C	SLG1	Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response [Source:SGD;Acc:S000005534]	Rho protein signal transduction, actin cytoskeleton organization, cell cycle, cellular cell wall organization, establishment of cell polarity, fungal-type cell wall organization, peroxisome degradation, positive regulation of endocytosis, response to heat, response to osmotic stress, response to stress	actin cap, cellular bud neck, integral to membrane, mating projection tip, membrane, membrane fraction, plasma membrane	transmembrane receptor activity		
YOR008C-A	YOR008C-A	Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres [Source:SGD;Acc:S000006431]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR008W-B	YOR008W-B	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007628]					
YOR009W	TIR4	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock [Source:SGD;Acc:S000005535]	biological_process, cellular cell wall organization, response to stress	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YOR010C	TIR2	Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis [Source:SGD;Acc:S000005536]	response to stress	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function, structural constituent of cell wall		
YOR011W	AUS1	Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth [Source:SGD;Acc:S000005537]	sterol transport, transport	integral to membrane, membrane, mitochondrion	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YOR011W-A	YOR011W-A	Putative protein of unknown function [Source:SGD;Acc:S000028581]	biological_process	cellular_component	molecular_function		
YOR012W	YOR012W	Putative protein of unknown function [Source:SGD;Acc:S000005538]	biological_process	cellular_component	molecular_function		
YOR013W	IRC11	Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci [Source:SGD;Acc:S000005539]					
YOR014W	RTS1	B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A [Source:SGD;Acc:S000005540]	cellular protein localization, meiotic sister chromatid cohesion, centromeric, mitotic cell cycle spindle orientation checkpoint, protein dephosphorylation, signal transduction	cellular bud neck, condensed nuclear chromosome, centromeric region, cytoplasm, nucleus, protein phosphatase type 2A complex, spindle pole body	binding, protein phosphatase type 2A regulator activity, protein serine/threonine phosphatase activity		
YOR015W	YOR015W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005541]					
YOR016C	ERP4	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport [Source:SGD;Acc:S000005542]	ER to Golgi vesicle-mediated transport, protein transport, transport, vesicle-mediated transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YOR017W	PET127	Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane [Source:SGD;Acc:S000005543]	mitochondrial RNA 5'-end processing	mitochondrial envelope, mitochondrion	molecular_function		
YOR018W	ROD1	Membrane protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene,zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins [Source:SGD;Acc:S000005544]	response to drug, ubiquitin-dependent endocytosis	membrane, plasma membrane	ubiquitin protein ligase binding		
YOR019W	YOR019W	Protein of unknown function that may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000005545]	cell cycle, mitochondrion degradation	ribosome	molecular_function		
YOR020C	HSP10	Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES [Source:SGD;Acc:S000005546]	protein folding, protein refolding	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, chaperone binding, unfolded protein binding		
YOR020W-A	YOR020W-A	Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000028526]	biological_process	integral to membrane, membrane, mitochondrion	molecular_function		
YOR021C	YOR021C	Putative protein of unknown function; YOR021C is not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism [Source:SGD;Acc:S000005547]	biological_process	cellular_component, cytoplasm	molecular_function		
YOR022C	YOR022C	Protein with similarity to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005548]	biological_process, lipid catabolic process	mitochondrion	hydrolase activity, metal ion binding, phospholipase activity		
YOR023C	AHC1	Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex [Source:SGD;Acc:S000005549]	histone acetylation	Ada2/Gcn5/Ada3 transcription activator complex, cytoplasm, intracellular, nucleus	histone acetyltransferase activity, zinc ion binding		
YOR024W	YOR024W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005550]					
YOR025W	HST3	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism [Source:SGD;Acc:S000005551]	chromatin silencing, chromatin silencing at telomere, histone deacetylation, protein deacetylation, short-chain fatty acid metabolic process	cytoplasm, nucleus	DNA binding, NAD+ binding, histone deacetylase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, metal ion binding, zinc ion binding		
YOR026W	BUB3	Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p [Source:SGD;Acc:S000005552]	cell cycle, mitotic cell cycle G2/M transition decatenation checkpoint, mitotic cell cycle spindle assembly checkpoint	condensed nuclear chromosome kinetochore, mitotic checkpoint complex, nucleus	protein binding, ubiquitin binding		
YOR027W	STI1	Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop [Source:SGD;Acc:S000005553]	protein folding, response to stress	cytoplasm	ATPase inhibitor activity, Hsp70 protein binding, Hsp90 protein binding, binding, protein binding		
YOR028C	CIN5	Basic leucine zipper (bZIP) transcription factor of the yAP-1 family, mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions [Source:SGD;Acc:S000005554]	regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to drug, response to salt stress	cytoplasm, nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YOR029W	YOR029W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005555]					
YOR030W	DFG16	Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p [Source:SGD;Acc:S000005556]	protein processing, pseudohyphal growth	cellular_component, integral to membrane, membrane	molecular_function		
YOR031W	CRS5	Copper-binding metallothionein, required for wild-type copper resistance [Source:SGD;Acc:S000005557]	response to metal ion	cytoplasm	copper ion binding, metal ion binding		
YOR032C	HMS1	Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant [Source:SGD;Acc:S000005558]	pseudohyphal growth	cellular_component, nucleus	DNA binding, sequence-specific DNA binding transcription factor activity		
YOR032W-A	YOR032W-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028710]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR033C	EXO1	5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains [Source:SGD;Acc:S000005559]	DNA double-strand break processing, DNA repair, gene conversion at mating-type locus, DNA double-strand break processing, meiotic DNA double-strand break processing, mismatch repair, response to DNA damage stimulus, telomere maintenance	nucleus	5'-3' exonuclease activity, 5'-flap endonuclease activity, DNA binding, catalytic activity, exonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding, nuclease activity		
YOR034C	AKR2	Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p [Source:SGD;Acc:S000005560]	endocytosis, protein palmitoylation	Golgi apparatus, integral to membrane, membrane	acyltransferase activity, metal ion binding, protein binding, protein-cysteine S-palmitoleyltransferase activity, transferase activity, zinc ion binding		
YOR034C-A	YOR034C-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028856]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR035C	SHE4	Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization [Source:SGD;Acc:S000005561]	actin cytoskeleton organization, intracellular mRNA localization, mating type switching	cytoplasm	binding, myosin binding		
YOR036W	PEP12	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin [Source:SGD;Acc:S000005562]	Golgi to vacuole transport, intracellular protein transport, vacuole inheritance, vesicle-mediated transport	Golgi apparatus, endosome, integral to membrane, membrane	SNAP receptor activity, protein binding		
YOR037W	CYC2	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) [Source:SGD;Acc:S000005563]	cytochrome c-heme linkage, mitochondrial membrane organization, oxidation-reduction process	extrinsic to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion	oxidoreductase activity		
YOR038C	HIR2	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p [Source:SGD;Acc:S000005564]	DNA replication-independent nucleosome assembly, chromatin modification, regulation of transcription from RNA polymerase II promoter, transcription elongation from RNA polymerase II promoter	HIR complex, nucleus	DNA binding, nucleosome binding, protein binding, transcription corepressor activity		
YOR039W	CKB2	Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases [Source:SGD;Acc:S000005565]	protein phosphorylation, regulation of transcription from RNA polymerase I promoter, regulation of transcription from RNA polymerase III promoter, response to DNA damage stimulus	CURI complex, UTP-C complex, protein kinase CK2 complex	protein kinase regulator activity, protein serine/threonine kinase inhibitor activity		
YOR040W	GLO4	Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate [Source:SGD;Acc:S000005566]	cellular carbohydrate metabolic process, methylglyoxal catabolic process to D-lactate	mitochondrial matrix, mitochondrion	hydrolase activity, hydroxyacylglutathione hydrolase activity, metal ion binding		
YOR041C	YOR041C	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance [Source:SGD;Acc:S000005567]					
YOR042W	CUE5	Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000005568]	biological_process	cytoplasm	protein binding, ubiquitin binding		
YOR043W	WHI2	Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression [Source:SGD;Acc:S000005569]	actin filament organization, cell cycle, endocytosis, regulation of growth, response to heat, response to salt stress, response to stress	cellular_component	phosphatase activator activity		
YOR044W	IRC23	Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000005570]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YOR045W	TOM6	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex [Source:SGD;Acc:S000005571]	protein import into mitochondrial matrix, protein transport, transport	integral to membrane, membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion	protein channel activity		
YOR046C	DBP5	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination [Source:SGD;Acc:S000005572]	mRNA export from nucleus, mRNA transport, protein transport, translational termination, transmembrane transport, transport	cellular bud tip, cytoplasm, membrane, nuclear membrane, nuclear pore, nucleus, polysome	ATP binding, ATP-dependent helicase activity, RNA binding, RNA helicase activity, RNA-dependent ATPase activity, helicase activity, hydrolase activity, inositol hexakisphosphate binding, nucleic acid binding, nucleotide binding		
YOR047C	STD1	Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p [Source:SGD;Acc:S000005573]	glucose metabolic process, nicotinamide riboside biosynthetic process, nicotinic acid riboside biosynthetic process, regulation of transcription from RNA polymerase II promoter, response to salt stress, signal transduction	nucleus, plasma membrane	protein kinase activator activity		
YOR048C	RAT1	Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination [Source:SGD;Acc:S000005574]	RNA processing, mRNA processing, nuclear mRNA surveillance, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, rRNA processing, termination of RNA polymerase II transcription, exosome-dependent, termination of RNA polymerase II transcription, poly(A)-coupled, transcription termination, DNA-dependent	intracellular, mitochondrion, nucleus	5'-3' exoribonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding		
YOR049C	RSB1	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane [Source:SGD;Acc:S000005575]	fatty acid transport, lipid transport, phospholipid translocation, response to stress, transport	endoplasmic reticulum, integral to membrane, membrane, plasma membrane	phospholipid-translocating ATPase activity		
YOR050C	YOR050C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable [Source:SGD;Acc:S000005576]					
YOR051C	ETT1	Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough [Source:SGD;Acc:S000005577]	translational termination	nucleus	binding, molecular_function		
YOR052C	YOR052C	Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid [Source:SGD;Acc:S000005578]	biological_process	nucleus	metal ion binding, molecular_function, zinc ion binding		
YOR053W	YOR053W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C [Source:SGD;Acc:S000005579]					
YOR054C	VHS3	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis [Source:SGD;Acc:S000005580]	cell cycle, cellular monovalent inorganic cation homeostasis, coenzyme A biosynthetic process	phosphopantothenoylcysteine decarboxylase complex	catalytic activity, phosphopantothenoylcysteine decarboxylase activity, protein phosphatase inhibitor activity		
YOR055W	YOR055W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005581]					
YOR056C	NOB1	Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA [Source:SGD;Acc:S000005582]	maturation of SSU-rRNA, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), proteasome assembly, ribosomal small subunit biogenesis, ribosome biogenesis	cytoplasm, endoplasmic reticulum, nucleolus, nucleus, preribosome, small subunit precursor	SSU rRNA binding, endoribonuclease activity, hydrolase activity, metal ion binding, nuclease activity		
YOR057W	SGT1	Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes [Source:SGD;Acc:S000005583]	cAMP-mediated signaling, cell cycle, kinetochore assembly, protein complex assembly, protein ubiquitination, regulation of cell cycle	ubiquitin ligase complex	binding, chaperone binding, protein binding, bridging		
YOR058C	ASE1	Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate [Source:SGD;Acc:S000005584]	cytokinesis, completion of separation, microtubule bundle formation, mitotic anaphase B, mitotic spindle elongation, mitotic spindle stabilization, spindle midzone assembly, spindle pole body separation	cytoplasm, cytoskeleton, microtubule, nuclear microtubule, spindle, spindle midzone	microtubule binding		
YOR059C	YOR059C	Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor RPN4 [Source:SGD;Acc:S000005585]	biological_process, lipid catabolic process, lipid metabolic process	integral to membrane, lipid particle, membrane	hydrolase activity, molecular_function		
YOR060C	YOR060C	Protein of unknown function required for cell viability; deletion mutant harbors aberrant mitochondria [Source:SGD;Acc:S000005586]	mitochondrion organization	cytoplasm, cytoskeleton, endoplasmic reticulum, nuclear envelope, nucleus, spindle pole, spindle pole body	molecular_function		
YOR061W	CKA2	Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases [Source:SGD;Acc:S000005587]	chronological cell aging, protein phosphorylation, regulation of transcription from RNA polymerase I promoter, regulation of transcription from RNA polymerase III promoter, response to DNA damage stimulus	UTP-C complex, protein kinase CK2 complex	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YOR062C	YOR062C	Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000005588]	biological_process	cytoplasm, nucleus	molecular_function		
YOR063W	RPL3	Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus [Source:SGD;Acc:S000005589]	ribosomal large subunit assembly, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOR064C	YNG1	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1 [Source:SGD;Acc:S000005590]	chromatin modification, histone acetylation	NuA3 histone acetyltransferase complex, nucleus	histone acetyltransferase activity, metal ion binding, methylated histone residue binding, protein binding, zinc ion binding		
YOR065W	CYT1	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex [Source:SGD;Acc:S000005591]	electron transport chain, mitochondrial electron transport, ubiquinol to cytochrome c, oxidative phosphorylation, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial respiratory chain, mitochondrial respiratory chain complex III, mitochondrion, respiratory chain	electron carrier activity, electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity, heme binding, iron ion binding, metal ion binding		
YOR066W	MSA1	Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation [Source:SGD;Acc:S000005592]	G1/S transition of mitotic cell cycle, cell cycle, regulation of cell size, regulation of transcription involved in G1 phase of mitotic cell cycle	cytoplasm, nucleus	molecular_function		
YOR067C	ALG8	Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p [Source:SGD;Acc:S000005593]	oligosaccharide-lipid intermediate biosynthetic process, protein N-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups		
YOR068C	VAM10	Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering [Source:SGD;Acc:S000005594]	vacuole fusion, non-autophagic	membrane, vacuolar membrane, vacuole	molecular_function		
YOR069W	VPS5	Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p [Source:SGD;Acc:S000005595]	cell communication, protein retention in Golgi apparatus, protein transport, retrograde transport, endosome to Golgi, transport	Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endosome, endosome membrane, membrane, retromer complex, retromer complex, outer shell	phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding, protein transporter activity		
YOR070C	GYP1	Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion [Source:SGD;Acc:S000005596]	regulation of Rab GTPase activity, vesicle-mediated transport	Golgi apparatus, Golgi stack, intracellular, mitochondrion	GTPase activator activity, Rab GTPase activator activity		
YOR071C	NRT1	High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity [Source:SGD;Acc:S000005597]	nicotinamide riboside transport, nucleobase, nucleoside, nucleotide and nucleic acid transport, thiamine transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	nicotinamide riboside transporter activity, nucleobase transmembrane transporter activity		
YOR072W	YOR072W	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive [Source:SGD;Acc:S000005598]					
YOR072W-A	YOR072W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028582]					
YOR072W-B	YOR072W-B	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028516]	biological_process	cellular_component	molecular_function		
YOR073W	SGO1	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability [Source:SGD;Acc:S000005599]	cell cycle, cell division, chromosome segregation, maintenance of meiotic sister chromatid cohesion, meiosis, meiotic chromosome segregation, meiotic sister chromatid segregation, meiotic sister chromatid separation, mitosis, mitotic cell cycle spindle assembly checkpoint, mitotic sister chromatid segregation, positive regulation of maintenance of meiotic sister chromatid cohesion, sister chromatid biorientation	chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, condensed nuclear chromosome, centromeric region, cytoplasm, cytoskeleton, kinetochore, nucleus, spindle pole, spindle pole body	molecular_function		
YOR073W-A	YOR073W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR [Source:SGD;Acc:S000028583]					
YOR074C	CDC21	Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S [Source:SGD;Acc:S000005600]	dTMP biosynthetic process, nucleotide biosynthetic process	nucleus	methyltransferase activity, thymidylate synthase activity, transferase activity		
YOR075W	UFE1	t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER [Source:SGD;Acc:S000005601]	endoplasmic reticulum membrane fusion, protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle fusion with endoplasmic reticulum, vesicle-mediated transport	SNARE complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	SNAP receptor activity, protein binding		
YOR076C	SKI7	Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype [Source:SGD;Acc:S000005602]	nonfunctional rRNA decay, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translation, translation	Ski complex, cytoplasm, cytoplasmic exosome (RNase complex)	GTP binding, GTPase activity, nucleotide binding, protein binding, bridging		
YOR077W	RTS2	Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication [Source:SGD;Acc:S000005603]	biological_process	cytoplasm, intracellular, nucleus	DNA binding, metal ion binding, molecular_function, zinc ion binding		
YOR078W	BUD21	Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern [Source:SGD;Acc:S000005604]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	snoRNA binding		
YOR079C	ATX2	Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation [Source:SGD;Acc:S000005605]	cellular manganese ion homeostasis, metal ion transport, transmembrane transport	Golgi apparatus, Golgi membrane, integral to membrane, membrane	manganese ion transmembrane transporter activity, metal ion transmembrane transporter activity		
YOR080W	DIA2	Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth [Source:SGD;Acc:S000005606]	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, invasive growth in response to glucose limitation, protein ubiquitination, regulation of DNA replication	SCF ubiquitin ligase complex, nuclear replication fork, nucleus	DNA replication origin binding, binding, protein binding, ubiquitin-protein ligase activity		
YOR081C	TGL5	Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate [Source:SGD;Acc:S000005607]	lipid catabolic process, lipid metabolic process, metabolic process, sporulation resulting in formation of a cellular spore, triglyceride mobilization	integral to membrane, lipid particle, membrane	GTP binding, hydrolase activity, lysophosphatidic acid acyltransferase activity, triglyceride lipase activity		
YOR082C	YOR082C	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W [Source:SGD;Acc:S000005608]					
YOR083W	WHI5	Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1 [Source:SGD;Acc:S000005609]	cell cycle, regulation of cell size, regulation of transcription involved in G1/S phase of mitotic cell cycle	cytoplasm, nucleus			
YOR084W	LPX1	Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction [Source:SGD;Acc:S000005610]	peroxisome organization	peroxisomal matrix, peroxisome	hydrolase activity, lipase activity		
YOR085W	OST3	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins [Source:SGD;Acc:S000005611]	protein N-linked glycosylation, protein complex assembly, protein glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity, transferase activity		
YOR086C	TCB1	Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact [Source:SGD;Acc:S000005612]	biological_process	integral to membrane, membrane, mitochondrion, plasma membrane, plasma membrane enriched fraction	calcium-dependent phospholipid binding, lipid binding, metal ion binding, protein binding		
YOR087W	YVC1	Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock [Source:SGD;Acc:S000005613]	calcium ion transport, cellular cation homeostasis, ion transport, transport	fungal-type vacuole, fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	calcium activated cation channel activity, calcium channel activity, ion channel activity, potassium channel activity, sodium channel activity, voltage-gated ion channel activity		
YOR089C	VPS21	Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog [Source:SGD;Acc:S000005615]	endocytosis, protein targeting to vacuole, protein transport, small GTPase mediated signal transduction, transport, vacuole inheritance	endosome, endosome membrane, late endosome, membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion	GTP binding, GTPase activity, nucleotide binding		
YOR090C	PTC5	Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p [Source:SGD;Acc:S000005616]	positive regulation of catalytic activity, protein dephosphorylation, regulation of catalytic activity	integral to membrane, membrane, mitochondrial membrane, mitochondrion, protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity, catalytic activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YOR091W	TMA46	Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p [Source:SGD;Acc:S000005617]	translation	cytoplasm, polysomal ribosome, ribosome	metal ion binding, molecular_function, nucleic acid binding, zinc ion binding		
YOR092W	ECM3	Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000005618]	cellular cell wall organization, fungal-type cell wall organization, transmembrane transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	ATPase activity		
YOR093C	YOR093C	Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents [Source:SGD;Acc:S000005619]	biological_process, metabolic process	cellular_component, integral to membrane, membrane, nucleus	catalytic activity, molecular_function, transcription factor binding		
YOR094W	ARF3	Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity [Source:SGD;Acc:S000005620]	actin cortical patch localization, actin filament bundle assembly, cellular bud site selection, endocytosis, intracellular protein transport, positive regulation of phosphatidylinositol biosynthetic process, protein transport, small GTPase mediated signal transduction, transport, vesicle-mediated transport	Golgi apparatus, cellular bud neck, cellular bud tip, intracellular	GTP binding, GTPase activity, mRNA binding, nucleotide binding		
YOR095C	RKI1	Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis [Source:SGD;Acc:S000005621]	pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch, pyridoxine biosynthetic process	cytoplasm, nucleus	isomerase activity, ribose-5-phosphate isomerase activity		
YOR096W	RPS7A	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins [Source:SGD;Acc:S000005622]	rRNA processing, ribosome biogenesis, translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small-subunit processome	structural constituent of ribosome		
YOR097C	YOR097C	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene [Source:SGD;Acc:S000005623]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR098C	NUP1	Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate [Source:SGD;Acc:S000005624]	NLS-bearing substrate import into nucleus, RNA export from nucleus, mRNA export from nucleus, mRNA transport, mRNA-binding (hnRNP) protein import into nucleus, nuclear envelope organization, nuclear pore organization, protein export from nucleus, protein import into nucleus, protein transport, rRNA export from nucleus, ribosomal protein import into nucleus, snRNA export from nucleus, snRNP protein import into nucleus, tRNA export from nucleus, transmembrane transport, transport	membrane, nuclear membrane, nuclear pore, nucleus	protein binding, structural molecule activity		
YOR099W	KTR1	Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000005625]	N-glycan processing, cell wall mannoprotein biosynthetic process, protein O-linked glycosylation, protein glycosylation	Golgi apparatus, Golgi membrane, integral to membrane, membrane	alpha-1,2-mannosyltransferase activity, glycolipid 2-alpha-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YOR100C	CRC1	Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation [Source:SGD;Acc:S000005626]	fatty acid metabolic process, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, carnitine:acyl carnitine antiporter activity		
YOR101W	RAS1	GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes [Source:SGD;Acc:S000005627]	Ras protein signal transduction, activation of adenylate cyclase activity by G-protein signaling pathway, replicative cell aging, signal transduction, small GTPase mediated signal transduction	intracellular, membrane, plasma membrane	GTP binding, GTPase activity, nucleotide binding		
YOR102W	YOR102W	Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex [Source:SGD;Acc:S000005628]					
YOR103C	OST2	Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins [Source:SGD;Acc:S000005629]	protein N-linked glycosylation	integral to membrane, membrane, oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity, transferase activity		
YOR104W	PIN2	Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated [Source:SGD;Acc:S000005630]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR105W	YOR105W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005631]					
YOR106W	VAM3	Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; multispecificity vacuolar t-SNARE that mediates docking/fusion of multiple distinct late transport intermediates with the vacuole [Source:SGD;Acc:S000005632]	Golgi to vacuole transport, autophagy, intracellular protein transport, piecemeal microautophagy of nucleus, vesicle docking, vesicle fusion, vesicle fusion with vacuole, vesicle-mediated transport	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	SNAP receptor activity, protein binding		
YOR107W	RGS2	Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p [Source:SGD;Acc:S000005633]	G-protein signaling, coupled to cAMP nucleotide second messenger	cytoplasm, nucleus	GTPase activator activity, signal transducer activity		
YOR108C-A	YOR108C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028711]					
YOR108W	LEU9	Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant [Source:SGD;Acc:S000005634]	branched chain family amino acid biosynthetic process, carboxylic acid metabolic process, cellular amino acid biosynthetic process, leucine biosynthetic process, metabolic process	mitochondrion	2-isopropylmalate synthase activity, catalytic activity, transferase activity, transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer		
YOR109W	INP53	Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains [Source:SGD;Acc:S000005635]	endocytosis, phosphatidylinositol dephosphorylation, protein transport, transport	actin cortical patch, cytoplasm, membrane fraction, vesicular fraction	hydrolase activity, inositol or phosphatidylinositol phosphatase activity, phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-3-phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-4-phosphate phosphatase activity, phosphoric ester hydrolase activity		
YOR110W	TFC7	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes [Source:SGD;Acc:S000005636]	transcription initiation from RNA polymerase III promoter	nucleus, transcription factor TFIIIC complex	DNA binding		
YOR111W	YOR111W	Putative protein of unknown function [Source:SGD;Acc:S000005637]	biological_process	cellular_component, cytoplasm	molecular_function		
YOR112W	CEX1	Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p [Source:SGD;Acc:S000005638]	tRNA export from nucleus	cytoplasm, nuclear pore	binding, tRNA binding		
YOR113W	AZF1	Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance [Source:SGD;Acc:S000005639]	regulation of transcription, DNA-dependent, response to carbohydrate stimulus	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YOR114W	YOR114W	Putative protein of unknown function; null mutant is viable [Source:SGD;Acc:S000005640]	biological_process	cellular_component	molecular_function		
YOR115C	TRS33	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic [Source:SGD;Acc:S000005641]	ER to Golgi vesicle-mediated transport, cGMP biosynthetic process, protein complex assembly, transport, vesicle-mediated transport	Golgi apparatus, TRAPP complex, cis-Golgi network, endoplasmic reticulum, trans-Golgi network	guanylate cyclase activity, heme binding, molecular_function		
YOR116C	RPO31	RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 [Source:SGD;Acc:S000005642]	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase III complex, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding, nucleotidyltransferase activity, ribonucleoside binding, transferase activity, zinc ion binding		
YOR117W	RPT5	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 [Source:SGD;Acc:S000005643]	proteasome regulatory particle assembly, protein catabolic process, protein processing, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus, proteasome complex, proteasome regulatory particle, base subcomplex	ATP binding, ATPase activity, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding		
YOR118W	RTC5	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity [Source:SGD;Acc:S000005644]	biological_process	cytoplasm	molecular_function		
YOR119C	RIO1	Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA [Source:SGD;Acc:S000005645]	S phase of mitotic cell cycle, cell cycle, cell division, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), mitosis, protein phosphorylation, regulation of exit from mitosis, ribosome biogenesis	cytoplasm, nucleus	ATP binding, catalytic activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YOR120W	GCY1	Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family [Source:SGD;Acc:S000005646]	D-xylose catabolic process, arabinose catabolic process, cellular response to oxidative stress, oxidation-reduction process	cytoplasm, nucleus	alditol:NADP+ 1-oxidoreductase activity, aldo-keto reductase (NADP) activity, mRNA binding, oxidoreductase activity		
YOR121C	YOR121C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W [Source:SGD;Acc:S000005647]					
YOR122C	PFY1	Profilin, binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress [Source:SGD;Acc:S000005648]	actin cytoskeleton organization, cytoskeleton organization, intracellular transport, positive regulation of formin-nucleated actin cable assembly, sequestering of actin monomers	actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, extrinsic to plasma membrane	actin binding, actin monomer binding, phosphatidylinositol-4,5-bisphosphate binding, proline-rich region binding		
YOR123C	LEO1	Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000005649]	histone methylation, transcription elongation from RNA polymerase II promoter, transcription from RNA polymerase II promoter	Cdc73/Paf1 complex, nucleoplasm, nucleus, transcription elongation factor complex			
YOR124C	UBP2	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity [Source:SGD;Acc:S000005650]	protein deubiquitination, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytoplasm	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YOR125C	CAT5	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation [Source:SGD;Acc:S000005651]	carbohydrate metabolic process, gluconeogenesis, glucose metabolic process, oxidation-reduction process, protein metabolic process, ubiquinone biosynthetic process	membrane, mitochondrial inner membrane, mitochondrion	metal ion binding, monooxygenase activity, oxidoreductase activity, transition metal ion binding		
YOR126C	IAH1	Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing [Source:SGD;Acc:S000005652]	acetate metabolic process, lipid catabolic process, lipid metabolic process	cellular_component	hydrolase activity, hydrolase activity, acting on ester bonds		
YOR127W	RGA1	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth [Source:SGD;Acc:S000005653]	actin filament organization, budding cell apical bud growth, budding cell isotropic bud growth, establishment of cell polarity, invasive growth in response to glucose limitation, pheromone-dependent signal transduction involved in conjugation with cellular fusion, pseudohyphal growth, response to pheromone, signal transduction, small GTPase mediated signal transduction	cellular bud neck split septin rings, intracellular	GTPase activator activity, Rho GTPase activator activity, metal ion binding, zinc ion binding		
YOR128C	ADE2	Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine [Source:SGD;Acc:S000005654]	'de novo' IMP biosynthetic process, purine base metabolic process, purine nucleotide biosynthetic process	cytoplasm	ATP binding, carboxy-lyase activity, catalytic activity, lyase activity, nucleotide binding, phosphoribosylaminoimidazole carboxylase activity		
YOR129C	AFI1	Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p [Source:SGD;Acc:S000005655]	actin cortical patch localization, asymmetric protein localization, cellular bud site selection	cell cortex, cellular bud neck, cytoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane	molecular_function		
YOR130C	ORT1	Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome [Source:SGD;Acc:S000005656]	arginine biosynthetic process, cellular amino acid biosynthetic process, mitochondrial ornithine transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion	L-ornithine transmembrane transporter activity, binding		
YOR131C	YOR131C	Putative protein of unknown function; non-essential gene; overexpression causes a cell cycle delay or arrest [Source:SGD;Acc:S000005657]	biological_process, metabolic process	cytoplasm, nucleus	catalytic activity, hydrolase activity, molecular_function, phosphoglycolate phosphatase activity		
YOR132W	VPS17	Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation [Source:SGD;Acc:S000005658]	cell communication, protein transport, retrograde transport, endosome to Golgi, transport	endomembrane system, endosome, membrane, retromer complex, retromer complex, outer shell	phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding, protein transporter activity		
YOR133W	EFT1	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin [Source:SGD;Acc:S000005659]	translation, translational elongation	cytoplasm, ribosome	GTP binding, GTPase activity, RNA binding, nucleotide binding, rRNA binding, translation elongation factor activity		
YOR134W	BAG7	Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p [Source:SGD;Acc:S000005660]	signal transduction, small GTPase mediated signal transduction	intracellular	GTPase activator activity, Rho GTPase activator activity		
YOR135C	IRC14	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci [Source:SGD;Acc:S000005661]					
YOR136W	IDH2	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated [Source:SGD;Acc:S000005662]	glutamate biosynthetic process, isocitrate metabolic process, oxidation-reduction process, tricarboxylic acid cycle	mitochondrial isocitrate dehydrogenase complex (NAD+), mitochondrial matrix, mitochondrion	NAD binding, RNA binding, catalytic activity, isocitrate dehydrogenase (NAD+) activity, magnesium ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YOR137C	SIA1	Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose [Source:SGD;Acc:S000005663]	proton transport	cellular_component	hydrolase activity, molecular_function		
YOR138C	RUP1	Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain [Source:SGD;Acc:S000005664]	protein deubiquitination	cytoplasm, nucleus	protein binding		
YOR139C	YOR139C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W [Source:SGD;Acc:S000005665]					
YOR140W	SFL1	Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p [Source:SGD;Acc:S000005666]	negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	nuclear chromosome, nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YOR141C	ARP8	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity [Source:SGD;Acc:S000005667]	chromatin remodeling, mitotic recombination, response to DNA damage stimulus	Ino80 complex, cytoplasm, cytoskeleton, nucleus	ATP-dependent 3'-5' DNA helicase activity, mRNA binding		
YOR142W	LSC1	Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated [Source:SGD;Acc:S000005668]	metabolic process, succinyl-CoA metabolic process, tricarboxylic acid cycle	mitochondrial nucleoid, mitochondrion	ATP binding, ATP citrate synthase activity, GTP binding, binding, catalytic activity, ligase activity, nucleotide binding, succinate-CoA ligase (ADP-forming) activity		
YOR142W-A	YOR142W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007351]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YOR142W-B	YOR142W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007352]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YOR143C	THI80	Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate) [Source:SGD;Acc:S000005669]	thiamine diphosphate biosynthetic process, thiamine metabolic process	cytoplasm	ATP binding, kinase activity, nucleotide binding, thiamine diphosphokinase activity, transferase activity		
YOR144C	ELG1	Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair [Source:SGD;Acc:S000005670]	DNA-dependent DNA replication, cell cycle, double-strand break repair via homologous recombination, mitotic sister chromatid cohesion, negative regulation of DNA recombination, negative regulation of transposition, RNA-mediated, telomere maintenance	Elg1 RFC-like complex, chromosome, telomeric region, cytoplasm, mitochondrion, nucleus	molecular_function		
YOR145C	PNO1	Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain [Source:SGD;Acc:S000005671]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), protein complex assembly, ribosome biogenesis	90S preribosome, cytoplasm, nucleolus, nucleus	RNA binding, unfolded protein binding		
YOR146W	YOR146W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C [Source:SGD;Acc:S000005672]					
YOR147W	MDM32	Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 [Source:SGD;Acc:S000005673]	cellular ion homeostasis, mitochondrion inheritance, mitochondrion organization	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YOR148C	SPP2	Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction [Source:SGD;Acc:S000005674]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	cytoplasm, intracellular, nucleus, spliceosomal complex	molecular_function, nucleic acid binding		
YOR149C	SMP3	Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure [Source:SGD;Acc:S000005675]	GPI anchor biosynthetic process, plasmid maintenance	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, intrinsic to endoplasmic reticulum membrane, membrane	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YOR150W	MRPL23	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000005676]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOR151C	RPB2	RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit [Source:SGD;Acc:S000005677]	transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex, mitochondrion, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding, nucleotidyltransferase activity, ribonucleoside binding, transferase activity		
YOR152C	YOR152C	Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene [Source:SGD;Acc:S000005678]	biological_process	integral to membrane, membrane, membrane fraction	molecular_function		
YOR153W	PDR5	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth [Source:SGD;Acc:S000005679]	drug transport, response to antibiotic, response to cycloheximide, response to drug, transport	integral to membrane, membrane, mitochondrion, plasma membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding, xenobiotic-transporting ATPase activity		
YOR154W	SLP1	Integral membrane protein of unknown function; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins [Source:SGD;Acc:S000005680]	protein folding in endoplasmic reticulum	cellular_component, integral to membrane, membrane	molecular_function		
YOR155C	ISN1	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms [Source:SGD;Acc:S000005681]	inosine salvage, nicotinamide riboside biosynthetic process, nicotinic acid riboside biosynthetic process, nucleotide metabolic process	cellular_component	IMP 5'-nucleotidase activity, hydrolase activity, magnesium ion binding, phosphatase activity		
YOR156C	NFI1	SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length [Source:SGD;Acc:S000005682]	chromosome condensation, chromosome segregation, protein sumoylation	cytoplasm, nuclear chromatin, nucleus	SUMO ligase activity, ligase activity, metal ion binding, nucleic acid binding, zinc ion binding		
YOR157C	PUP1	Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z [Source:SGD;Acc:S000005683]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteolysis involved in cellular protein catabolic process	cytoplasm, endoplasmic reticulum membrane, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, peptidase activity, threonine-type endopeptidase activity		
YOR158W	PET123	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator [Source:SGD;Acc:S000005684]	mitochondrial translation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOR159C	SME1	Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E [Source:SGD;Acc:S000005685]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, cytoplasm, nucleus, ribonucleoprotein complex	RNA binding, molecular_function		
YOR160W	MTR10	Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs [Source:SGD;Acc:S000005686]	RNA import into nucleus, RNA localization, intracellular protein transport, mRNA-binding (hnRNP) protein import into nucleus, protein import into nucleus, tRNA transport	cytoplasm, nucleus	binding, nuclear localization sequence binding, protein transporter activity		
YOR161C	PNS1	Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport [Source:SGD;Acc:S000005687]	biological_process, transport	integral to membrane, integral to plasma membrane, membrane, plasma membrane, plasma membrane enriched fraction	molecular_function		
YOR161C-C	YOR161C-C	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028712]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR161W-A	YOR161W-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028713]					
YOR161W-B	YOR161W-B	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028714]					
YOR162C	YRR1	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes [Source:SGD;Acc:S000005688]	drug transmembrane transport, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	cytoplasm, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YOR163W	DDP1	Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases [Source:SGD;Acc:S000005689]	diadenosine polyphosphate catabolic process, inositol phosphate dephosphorylation	cytoplasm, nucleus	bis(5'-adenosyl)-hexaphosphatase activity, bis(5'-adenosyl)-pentaphosphatase activity, diphosphoinositol-polyphosphate diphosphatase activity, hydrolase activity, metal ion binding		
YOR164C	GET4	Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20 [Source:SGD;Acc:S000005690]	posttranslational protein targeting to membrane, protein insertion into ER membrane, transport, vesicle-mediated transport	TRC complex, cytoplasm	molecular_function		
YOR165W	SEY1	GTPase with a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; possible functional ortholog of mammalian atlastins, defects in which cause a form of hereditary spastic paraplegia; homolog of Arabidopsis RHD3 [Source:SGD;Acc:S000005691]	cellular membrane organization, endoplasmic reticulum organization, response to stress	cortical endoplasmic reticulum, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	GTP binding, GTPase activity, hydrolase activity, nucleotide binding		
YOR166C	SWT1	RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain [Source:SGD;Acc:S000005692]	nuclear mRNA surveillance of mRNP export, transcription, DNA-dependent	cytoplasm, nucleus	endoribonuclease activity		
YOR167C	RPS28A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein [Source:SGD;Acc:S000005693]	rRNA export from nucleus, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOR168W	GLN4	Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions [Source:SGD;Acc:S000005694]	glutaminyl-tRNA aminoacylation, tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, cytosol, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, glutamine-tRNA ligase activity, ligase activity, ligase activity, forming aminoacyl-tRNA and related compounds, nucleotide binding		
YOR169C	YOR169C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W [Source:SGD;Acc:S000005695]					
YOR170W	YOR170W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4 [Source:SGD;Acc:S000005696]					
YOR171C	LCB4	Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes [Source:SGD;Acc:S000005697]	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, calcium-mediated signaling, lipid metabolic process, sphingolipid metabolic process	Golgi apparatus, Golgi membrane, cortical endoplasmic reticulum, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, late endosome membrane, membrane, membrane fraction, plasma membrane, soluble fraction	ATP binding, D-erythro-sphingosine kinase activity, diacylglycerol kinase activity, kinase activity, nucleotide binding, sphinganine kinase activity, transferase activity		
YOR172W	YRM1	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes [Source:SGD;Acc:S000005698]	drug transmembrane transport, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	cytoplasm, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YOR173W	DCS2	Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000005699]	deadenylation-dependent decapping of nuclear-transcribed mRNA, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm, cytoplasmic mRNA processing body	catalytic activity, hydrolase activity, m7G(5')pppN diphosphatase activity		
YOR174W	MED4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000005700]	transcription from RNA polymerase II promoter	mediator complex, nucleus			
YOR175C	ALE1	Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids [Source:SGD;Acc:S000005701]	glycerophospholipid biosynthetic process, phospholipid biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome, ribosome	1-acylglycerol-3-phosphate O-acyltransferase activity, 1-acylglycerophosphocholine O-acyltransferase activity, O-acyltransferase activity, acyltransferase activity, transferase activity		
YOR176W	HEM15	Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway [Source:SGD;Acc:S000005702]	heme biosynthetic process, porphyrin biosynthetic process	membrane, mitochondrial inner membrane, mitochondrion	ferrochelatase activity, lyase activity		
YOR177C	MPC54	Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate [Source:SGD;Acc:S000005703]	ascospore wall assembly, cell cycle, cell division, meiosis, sporulation resulting in formation of a cellular spore, vesicle docking	cytoplasm, cytoskeleton, membrane, nucleus, prospore membrane, spindle pole, spindle pole body	structural molecule activity		
YOR178C	GAC1	Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock [Source:SGD;Acc:S000005704]	glycogen biosynthetic process, glycogen metabolic process, meiosis, mitotic cell cycle spindle assembly checkpoint, negative regulation of transcription from RNA polymerase II promoter, response to heat	protein phosphatase type 1 complex	heat shock protein binding, protein binding, protein phosphatase type 1 regulator activity, structural molecule activity		
YOR179C	SYC1	Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs [Source:SGD;Acc:S000005705]	mRNA processing, termination of RNA polymerase II transcription, exosome-dependent, termination of RNA polymerase II transcription, poly(A)-coupled	mRNA cleavage and polyadenylation specificity factor complex, nucleus	RNA binding		
YOR180C	DCI1	Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed [Source:SGD;Acc:S000005706]	fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process, metabolic process	peroxisomal matrix, peroxisome	catalytic activity, dodecenoyl-CoA delta-isomerase activity, isomerase activity		
YOR181W	LAS17	Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP) [Source:SGD;Acc:S000005707]	actin cortical patch localization, actin filament organization, actin polymerization or depolymerization, bipolar cellular bud site selection, cytokinesis, endocytosis, positive regulation of actin filament bundle assembly, response to osmotic stress	actin cortical patch, cytoplasm, mating projection tip	cytoskeletal protein binding, protein binding		
YOR182C	RPS30B	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein [Source:SGD;Acc:S000005708]	translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOR183W	FYV12	Protein of unknown function, required for survival upon exposure to K1 killer toxin [Source:SGD;Acc:S000005709]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR184W	SER1	3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p [Source:SGD;Acc:S000005710]	L-serine biosynthetic process, cellular amino acid biosynthetic process, metabolic process, purine base biosynthetic process, serine family amino acid biosynthetic process	cytoplasm	O-phospho-L-serine:2-oxoglutarate aminotransferase activity, catalytic activity, pyridoxal phosphate binding, transaminase activity, transferase activity		
YOR185C	GSP2	GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability [Source:SGD;Acc:S000005711]	intracellular protein transport, nucleocytoplasmic transport, nucleus organization, protein transport, signal transduction, transport	nucleus	GTP binding, GTPase activity, nucleotide binding		
YOR186C-A	YOR186C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028715]					
YOR186W	YOR186W	Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent [Source:SGD;Acc:S000005712]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR187W	TUF1	Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans [Source:SGD;Acc:S000005713]	mitochondrial translation, mitochondrial translational elongation, translation, translational elongation	intracellular, mitochondrial matrix, mitochondrion	GTP binding, GTPase activity, nucleotide binding, translation elongation factor activity		
YOR188W	MSB1	Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4 [Source:SGD;Acc:S000005714]	establishment of cell polarity	cellular bud neck, cellular bud tip, mitochondrion	molecular_function		
YOR189W	IES4	Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses [Source:SGD;Acc:S000005715]	response to DNA damage stimulus	Ino80 complex, nucleus	molecular_function		
YOR190W	SPR1	Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance [Source:SGD;Acc:S000005716]	ascospore formation, carbohydrate metabolic process, cellular cell wall organization, metabolic process, sporulation resulting in formation of a cellular spore	ascospore wall, extracellular region, fungal-type cell wall	catalytic activity, cation binding, glucan exo-1,3-beta-glucosidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds		
YOR191W	ULS1	RING finger protein involved in proteolytic control of sumoylated substrates; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching [Source:SGD;Acc:S000005717]	chromatin assembly or disassembly, mating type switching	mitochondrion, nucleolus, nucleus	ATP binding, DNA binding, DNA-dependent ATPase activity, SUMO binding, helicase activity, hydrolase activity, metal ion binding, nucleic acid binding, nucleotide binding, protein binding, zinc ion binding		
YOR192C	THI72	Transporter of thiamine or related compound; shares sequence similarity with Thi7p [Source:SGD;Acc:S000005718]	nucleobase, nucleoside, nucleotide and nucleic acid transport, thiamine transport, transmembrane transport, transport	integral to membrane, membrane	nucleobase transmembrane transporter activity, transporter activity		
YOR192C-A	YOR192C-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007353]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YOR192C-B	YOR192C-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007354]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YOR192C-C	YOR192C-C	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028857]	biological_process	cellular_component	molecular_function		
YOR193W	PEX27	Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p [Source:SGD;Acc:S000005719]	peroxisome organization	membrane, peroxisomal membrane, peroxisome	molecular_function		
YOR194C	TOA1	TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA [Source:SGD;Acc:S000005720]	transcription initiation from RNA polymerase II promoter	nucleus, transcription factor TFIIA complex			
YOR195W	SLK19	Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate [Source:SGD;Acc:S000005721]	cell cycle, cell division, chromosome segregation, meiosis, mitosis, mitotic spindle organization in nucleus	chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleus, spindle, spindle midzone, spindle pole body	molecular_function		
YOR196C	LIP5	Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase [Source:SGD;Acc:S000005722]	lipoate biosynthetic process, metabolic process, protein lipoylation	mitochondrion	4 iron, 4 sulfur cluster binding, catalytic activity, iron-sulfur cluster binding, lipoate synthase activity, metal ion binding, transferase activity		
YOR197W	MCA1	Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon H2O2 treatment; contributes to clearance of insoluble protein aggregates during normal growth; may be involved in cell cycle progression [Source:SGD;Acc:S000005723]	apoptosis, cellular response to hydrogen peroxide, misfolded or incompletely synthesized protein catabolic process, proteolysis	cytoplasm, nucleus	cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity		
YOR198C	BFR1	Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity [Source:SGD;Acc:S000005724]	mRNA metabolic process, meiosis, regulation of mitosis	nuclear outer membrane-endoplasmic reticulum membrane network, polysome, ribonucleoprotein complex	RNA binding		
YOR199W	YOR199W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005725]					
YOR200W	YOR200W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c [Source:SGD;Acc:S000005726]					
YOR201C	MRM1	Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA [Source:SGD;Acc:S000005727]	RNA processing, rRNA modification	mitochondrion	RNA binding, RNA methyltransferase activity, methyltransferase activity, rRNA (guanine-N1-)-methyltransferase activity, transferase activity		
YOR202W	HIS3	Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p [Source:SGD;Acc:S000005728]	cellular amino acid biosynthetic process, histidine biosynthetic process	cellular_component	imidazoleglycerol-phosphate dehydratase activity, lyase activity		
YOR203W	YOR203W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation [Source:SGD;Acc:S000005729]					
YOR204W	DED1	ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility [Source:SGD;Acc:S000005730]	translation, translational initiation	cytoplasm	ATP binding, ATP-dependent RNA helicase activity, ATP-dependent helicase activity, RNA binding, RNA strand annealing activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, translation initiation factor activity		
YOR205C	GEP3	Protein of unknown function; null mutant is defective in respiration and interacts synthetically with prohibitin (phb1); the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005731]	biological_process	mitochondrion	molecular_function		
YOR206W	NOC2	Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors [Source:SGD;Acc:S000005732]	ribosomal subunit export from nucleus, ribosome assembly, ribosome biogenesis	Noc1p-Noc2p complex, Noc2p-Noc3p complex, mitochondrion, nucleolus, nucleus	molecular_function		
YOR207C	RET1	Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs [Source:SGD;Acc:S000005733]	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase III complex, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding, nucleotidyltransferase activity, ribonucleoside binding, transferase activity		
YOR208W	PTP2	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus [Source:SGD;Acc:S000005734]	dephosphorylation, inactivation of MAPK activity involved in osmosensory signaling pathway, osmosensory signaling pathway, pheromone-dependent signal transduction involved in conjugation with cellular fusion, protein dephosphorylation	cytoplasm, nucleus	hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity		
YOR209C	NPT1	Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus [Source:SGD;Acc:S000005735]	NAD biosynthetic process, chromatin silencing at rDNA, chromatin silencing at telomere, nicotinate nucleotide biosynthetic process, nicotinate nucleotide salvage, pyridine nucleotide biosynthetic process, replicative cell aging	cytoplasm, nucleus	nicotinate phosphoribosyltransferase activity, nicotinate-nucleotide diphosphorylase (carboxylating) activity, transferase activity, transferase activity, transferring glycosyl groups		
YOR210W	RPB10	RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III [Source:SGD;Acc:S000005736]	transcription from RNA polymerase I promoter, transcription from RNA polymerase II promoter, transcription from RNA polymerase III promoter, transcription, DNA-dependent	DNA-directed RNA polymerase I complex, DNA-directed RNA polymerase II, core complex, DNA-directed RNA polymerase III complex, nucleolus, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding, zinc ion binding		
YOR211C	MGM1	Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy [Source:SGD;Acc:S000005737]	mitochondrial fusion, mitochondrial genome maintenance, mitochondrion organization	extrinsic to mitochondrial inner membrane, integral to membrane, intrinsic to mitochondrial inner membrane, membrane, mitochondrial crista, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion	GTP binding, GTPase activity, hydrolase activity, nucleotide binding		
YOR212W	STE4	G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats [Source:SGD;Acc:S000005738]	heterotrimeric G-protein complex cycle, invasive growth in response to glucose limitation, pheromone-dependent signal transduction involved in conjugation with cellular fusion, regulation of transposition, RNA-mediated, response to pheromone, signal transduction	heterotrimeric G-protein complex, mating projection, plasma membrane	protein binding, signal transducer activity		
YOR213C	SAS5	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity [Source:SGD;Acc:S000005739]	chromatin modification, chromatin silencing at telomere, regulation of transcription, DNA-dependent	SAS acetyltransferase complex, nuclear chromatin, nuclear chromosome, telomeric region, nucleus	acetyltransferase activity, histone acetyltransferase activity		
YOR214C	YOR214C	Putative protein of unknown function; YOR214C is not an essential gene [Source:SGD;Acc:S000005740]	biological_process	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YOR215C	AIM41	Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000005741]	biological_process, translation	mitochondrion	carbon-nitrogen ligase activity, with glutamine as amido-N-donor, molecular_function		
YOR216C	RUD3	Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 [Source:SGD;Acc:S000005742]	ER to Golgi vesicle-mediated transport, transport, vesicle-mediated transport	Golgi apparatus, Golgi lumen	molecular_function, protein binding		
YOR217W	RFC1	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [Source:SGD;Acc:S000005743]	DNA repair, DNA replication, cell cycle, cell division, leading strand elongation, mismatch repair, mitotic cell cycle	DNA replication factor C complex, intracellular, nucleus	ATP binding, DNA binding, DNA clamp loader activity, nucleoside-triphosphatase activity, nucleotide binding		
YOR218C	YOR218C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W [Source:SGD;Acc:S000005744]					
YOR219C	STE13	Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor [Source:SGD;Acc:S000005745]	peptide pheromone maturation, proteolysis, response to pheromone	integral to membrane, membrane, trans-Golgi network, vacuolar membrane, vacuole	aminopeptidase activity, hydrolase activity, peptidase activity, serine-type peptidase activity		
YOR220W	RCN2	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; phosphorylated in response to alpha factor [Source:SGD;Acc:S000005746]	biological_process	cytoplasm	molecular_function		
YOR221C	MCT1	Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling [Source:SGD;Acc:S000005747]	aerobic respiration, fatty acid biosynthetic process, fatty acid metabolic process, lipid biosynthetic process, metabolic process	mitochondrion	[acyl-carrier-protein] S-malonyltransferase activity, acyltransferase activity, transferase activity		
YOR222W	ODC2	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism [Source:SGD;Acc:S000005748]	mitochondrial transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, dicarboxylic acid transmembrane transporter activity, transporter activity		
YOR223W	YOR223W	Putative protein of unknown function [Source:SGD;Acc:S000005749]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR224C	RPB8	RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III [Source:SGD;Acc:S000005750]	tRNA transcription from RNA polymerase III promoter, transcription from RNA polymerase I promoter, transcription from RNA polymerase II promoter, transcription from RNA polymerase III promoter	DNA-directed RNA polymerase I complex, DNA-directed RNA polymerase II, core complex, DNA-directed RNA polymerase III complex, nucleus	DNA-directed RNA polymerase activity		
YOR225W	YOR225W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005751]					
YOR226C	ISU2	Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable [Source:SGD;Acc:S000005752]	cellular iron ion homeostasis, iron-sulfur cluster assembly, tRNA wobble uridine modification	mitochondrial matrix, mitochondrion	2 iron, 2 sulfur cluster binding, iron ion binding, iron-sulfur cluster binding, metal ion binding, molecular_function		
YOR227W	HER1	Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000005753]	endoplasmic reticulum organization	cytoplasm, mitochondrion, ribosome	molecular_function		
YOR228C	YOR228C	Protein of unknown function, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000005754]	biological_process	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YOR229W	WTM2	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats [Source:SGD;Acc:S000005755]	meiosis, regulation of meiosis, response to DNA damage stimulus	nucleus	protein binding, sequence-specific DNA binding, transcription corepressor activity		
YOR230W	WTM1	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats [Source:SGD;Acc:S000005756]	meiosis, protein import into nucleus, regulation of meiosis	nucleus	protein binding, transcription corepressor activity		
YOR231C-A	YOR231C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028716]					
YOR231W	MKK1	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p [Source:SGD;Acc:S000005757]	peroxisome degradation, protein phosphorylation, signal transduction	cellular bud tip	ATP binding, MAP kinase kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YOR232W	MGE1	Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE [Source:SGD;Acc:S000005758]	protein folding, protein import into mitochondrial matrix, protein refolding	mitochondrial matrix, mitochondrion, presequence translocase-associated import motor	adenyl-nucleotide exchange factor activity, chaperone binding, protein homodimerization activity		
YOR233W	KIN4	Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck [Source:SGD;Acc:S000005759]	mitotic cell cycle spindle orientation checkpoint, protein phosphorylation	cell cortex, cellular bud neck, spindle pole body	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YOR234C	RPL33B	Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable [Source:SGD;Acc:S000005760]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOR235W	IRC13	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci [Source:SGD;Acc:S000005761]					
YOR236W	DFR1	Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function [Source:SGD;Acc:S000005762]	folic acid-containing compound metabolic process, glycine biosynthetic process, nucleotide biosynthetic process, one-carbon metabolic process, oxidation-reduction process	cytosol	NADP binding, dihydrofolate reductase activity, oxidoreductase activity		
YOR237W	HES1	Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP) [Source:SGD;Acc:S000005763]	endocytosis, exocytosis, lipid biosynthetic process, maintenance of cell polarity, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, sterol transport	cellular_component	lipid binding, oxysterol binding, sterol transporter activity		
YOR238W	YOR238W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000005764]	biological_process	cytoplasm	molecular_function		
YOR239W	ABP140	Nonessential protein that binds actin filaments and localizes to actin patches and cables, has similarity to S-adenosylmethionine (AdoMet)-dependent methyltransferases [Source:SGD;Acc:S000005765]	actin filament bundle assembly	actin cortical patch, actin filament, actin filament bundle, cytoplasm, cytoskeleton, mating projection tip	S-adenosylmethionine-dependent methyltransferase activity, actin binding, actin filament binding, methyltransferase activity, protein binding, bridging, transferase activity		
YOR241W	MET7	Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA [Source:SGD;Acc:S000005767]	biosynthetic process, folic acid-containing compound biosynthetic process, one-carbon metabolic process	cytoplasm, mitochondrion	ATP binding, ligase activity, nucleotide binding, tetrahydrofolylpolyglutamate synthase activity		
YOR242C	SSP2	Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis [Source:SGD;Acc:S000005768]	ascospore formation, ascospore wall assembly, sporulation resulting in formation of a cellular spore	ascospore wall, spore wall	molecular_function		
YOR243C	PUS7	Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria [Source:SGD;Acc:S000005769]	RNA modification, RNA splicing, enzyme-directed rRNA pseudouridine synthesis, mRNA processing, pseudouridine synthesis, rRNA processing, ribosome biogenesis, snRNA pseudouridine synthesis, tRNA processing, tRNA pseudouridine synthesis	nucleus	RNA binding, isomerase activity, pseudouridine synthase activity		
YOR244W	ESA1	Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus [Source:SGD;Acc:S000005770]	DNA repair, chromatin assembly or disassembly, chromatin modification, chromatin silencing at rDNA, histone acetylation, positive regulation of transcription elongation from RNA polymerase II promoter, regulation of cell cycle, regulation of transcription by chromatin organization, regulation of transcription from RNA polymerase II promoter, transcription elongation, DNA-dependent	NuA4 histone acetyltransferase complex, Piccolo NuA4 histone acetyltransferase complex, chromatin, nucleus	H4 histone acetyltransferase activity, chromatin binding, histone acetyltransferase activity, transferase activity, transferase activity, transferring acyl groups other than amino-acyl groups		
YOR245C	DGA1	Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles [Source:SGD;Acc:S000005771]	glycerol metabolic process, lipid biosynthetic process, lipid metabolic process, lipid storage, triglyceride biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, lipid particle, membrane	acyltransferase activity, diacylglycerol O-acyltransferase activity, transferase activity, transferase activity, transferring acyl groups other than amino-acyl groups		
YOR246C	YOR246C	Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts [Source:SGD;Acc:S000005772]	biological_process, metabolic process, oxidation-reduction process	integral to membrane, lipid particle, membrane	binding, catalytic activity, oxidoreductase activity		
YOR247W	SRL1	Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants [Source:SGD;Acc:S000005773]	cellular cell wall organization, fungal-type cell wall organization, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	cell surface, cell wall, cellular bud tip, cytoplasm, extracellular region, fungal-type cell wall, fungal-type vacuole	molecular_function		
YOR248W	YOR248W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005774]					
YOR249C	APC5	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000005775]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell cycle, cell division, chromatin assembly or disassembly, cyclin catabolic process, mitosis, mitotic metaphase/anaphase transition, mitotic sister chromatid segregation, mitotic spindle elongation, protein ubiquitination	anaphase-promoting complex, nucleus	ubiquitin-protein ligase activity		
YOR250C	CLP1	Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation [Source:SGD;Acc:S000005776]	mRNA 3'-end processing, mRNA cleavage, mRNA polyadenylation, mRNA processing	mRNA cleavage factor complex, nucleus	ATP binding, RNA binding, nucleotide binding		
YOR251C	TUM1	Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized [Source:SGD;Acc:S000005777]	sulfate transport, tRNA wobble position uridine thiolation, tRNA wobble uridine modification	cytoplasm, mitochondrion	thiosulfate sulfurtransferase activity, transferase activity		
YOR252W	TMA16	Protein of unknown function that associates with ribosomes [Source:SGD;Acc:S000005778]	biological_process	nucleus, ribosome	molecular_function		
YOR253W	NAT5	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing [Source:SGD;Acc:S000005779]	N-terminal protein amino acid acetylation, metabolic process	NatA complex, cytoplasm, cytosolic ribosome	N-acetyltransferase activity, acyltransferase activity, peptide alpha-N-acetyltransferase activity, transferase activity		
YOR254C	SEC63	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER [Source:SGD;Acc:S000005780]	SRP-dependent cotranslational protein targeting to membrane, cytosol to ER transport, posttranslational protein targeting to membrane, posttranslational protein targeting to membrane, translocation, protein folding, protein transport, transport	Sec62/Sec63 complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrion, nuclear inner membrane, nuclear membrane, nucleus	heat shock protein binding, protein transporter activity, unfolded protein binding		
YOR255W	OSW1	Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p [Source:SGD;Acc:S000005781]	ascospore formation, ascospore wall assembly, sporulation resulting in formation of a cellular spore	prospore membrane, spore wall	molecular_function		
YOR256C	TRE2	Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31 [Source:SGD;Acc:S000005782]	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cellular_component, integral to membrane, membrane	hydrolase activity, metal ion binding, metallopeptidase activity, molecular_function, peptidase activity		
YOR257W	CDC31	Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation [Source:SGD;Acc:S000005783]	cell cycle, cell division, mRNA transport, microtubule nucleation, mitosis, proteasomal ubiquitin-dependent protein catabolic process, protein transport, spindle pole body duplication in nuclear envelope, transmembrane transport, transport	cytoplasm, cytoskeleton, half bridge of spindle pole body, nuclear pore, nucleotide-excision repair factor 2 complex, nucleus, spindle pole body, transcription export complex 2	calcium ion binding, structural constituent of cytoskeleton		
YOR258W	HNT3	DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia [Source:SGD;Acc:S000005784]	DNA repair, response to DNA damage stimulus	cytoplasm, nucleus	DNA 5'-adenosine monophosphate hydrolase activity, DNA binding, catalytic activity, hydrolase activity		
YOR259C	RPT4	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization [Source:SGD;Acc:S000005785]	ER-associated protein catabolic process, positive regulation of protein catabolic process, positive regulation of transcription elongation from RNA polymerase II promoter, proteasome regulatory particle assembly, protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, nucleus, proteasome complex, proteasome regulatory particle, base subcomplex	ATP binding, ATPase activity, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding		
YOR260W	GCD1	Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000005786]	regulation of translation, regulation of translational initiation, translation	eukaryotic translation initiation factor 2B complex, guanyl-nucleotide exchange factor complex	guanyl-nucleotide exchange factor activity, transferase activity, translation initiation factor activity		
YOR261C	RPN8	Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p [Source:SGD;Acc:S000005787]	ubiquitin-dependent protein catabolic process	proteasome complex, proteasome regulatory particle, lid subcomplex, proteasome storage granule	molecular_function, protein binding		
YOR262W	YOR262W	Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP/GTP binding site motif; similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B [Source:SGD;Acc:S000005788]	establishment of mitotic sister chromatid cohesion	cytoplasm	GTP binding, molecular_function, nucleotide binding		
YOR263C	YOR263C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W [Source:SGD;Acc:S000005789]					
YOR264W	DSE3	Daughter cell-specific protein, may help establish daughter fate [Source:SGD;Acc:S000005790]	biological_process, cell cycle	cellular bud neck	molecular_function		
YOR265W	RBL2	Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A [Source:SGD;Acc:S000005791]	microtubule cytoskeleton organization, post-chaperonin tubulin folding pathway, protein folding, tubulin complex assembly	cytoplasm, cytoskeleton, microtubule	beta-tubulin binding, tubulin binding, unfolded protein binding		
YOR266W	PNT1	Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine [Source:SGD;Acc:S000005792]	protein insertion into mitochondrial membrane from inner side, response to antibiotic	integral to membrane, integral to mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YOR267C	HRK1	Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis [Source:SGD;Acc:S000005793]	cellular ion homeostasis, protein phosphorylation	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YOR268C	YOR268C	Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene [Source:SGD;Acc:S000005794]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR269W	PAC1	Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1 [Source:SGD;Acc:S000005795]	cell cycle, cell division, nuclear migration along microtubule, transport	cytoplasm, cytoplasmic microtubule, cytoskeleton, microtubule, nucleus	microtubule plus-end binding, protein binding		
YOR270C	VPH1	Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes [Source:SGD;Acc:S000005796]	ATP synthesis coupled proton transport, ion transport, polyphosphate metabolic process, protein complex assembly, proton transport, transport, vacuolar acidification	fungal-type vacuole, fungal-type vacuole membrane, integral to membrane, membrane, proton-transporting two-sector ATPase complex, proton-transporting domain, vacuolar membrane, vacuolar proton-transporting V-type ATPase, V0 domain, vacuole	hydrogen ion transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism		
YOR271C	FSF1	Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis [Source:SGD;Acc:S000005797]	biological_process, cation transport, ion transport, iron ion transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial membrane, mitochondrion	cation transmembrane transporter activity, molecular_function		
YOR272W	YTM1	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats [Source:SGD;Acc:S000005798]	chromosome organization, rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis	PeBoW complex, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor	molecular_function, protein binding		
YOR273C	TPO4	Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily [Source:SGD;Acc:S000005799]	spermidine transport, spermine transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane, vacuolar membrane	antiporter activity, spermidine transmembrane transporter activity, spermine transmembrane transporter activity, transporter activity		
YOR274W	MOD5	Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms [Source:SGD;Acc:S000005800]	tRNA modification, tRNA processing	cytoplasm, cytosol, mitochondrion, nucleolus, nucleus	ATP binding, metal ion binding, nucleotide binding, tRNA dimethylallyltransferase activity, transferase activity		
YOR275C	RIM20	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation [Source:SGD;Acc:S000005801]	invasive growth in response to glucose limitation, protein processing, proteolysis, response to pH, sporulation resulting in formation of a cellular spore	cytoplasm, nucleus	molecular_function		
YOR276W	CAF20	Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E [Source:SGD;Acc:S000005802]	negative regulation of translation, positive regulation of cytoplasmic mRNA processing body assembly, regulation of translation, translation	cytoplasm, mRNA cap binding complex	translation initiation factor activity, translation regulator activity		
YOR277C	YOR277C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 [Source:SGD;Acc:S000005803]					
YOR278W	HEM4	Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria [Source:SGD;Acc:S000005804]	heme biosynthetic process, porphyrin biosynthetic process, tetrapyrrole biosynthetic process	cellular_component	lyase activity, uroporphyrinogen-III synthase activity		
YOR279C	RFM1	DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance [Source:SGD;Acc:S000005805]	chromatin silencing, chromatin silencing at silent mating-type cassette	histone deacetylase complex, nucleus	unfolded protein binding		
YOR280C	FSH3	Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2 [Source:SGD;Acc:S000005806]	biological_process	cellular_component	carboxylesterase activity, hydrolase activity, molecular_function		
YOR281C	PLP2	Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP [Source:SGD;Acc:S000005807]	negative regulation of signal transduction, positive regulation of transcription from RNA polymerase II promoter by pheromones, protein folding, response to pheromone	cytoplasm	G-protein beta/gamma-subunit complex binding, actin binding		
YOR282W	YOR282W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C [Source:SGD;Acc:S000005808]					
YOR283W	YOR283W	Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene [Source:SGD;Acc:S000005809]	dephosphorylation, glycolysis, metabolic process	cytoplasm, nucleus	catalytic activity, isomerase activity, phosphatase activity, phosphoglycerate mutase activity		
YOR284W	HUA2	Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly [Source:SGD;Acc:S000005810]	biological_process	cytoplasm	molecular_function		
YOR285W	RDL1	Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane [Source:SGD;Acc:S000005811]	biological_process	endoplasmic reticulum, mitochondrial outer membrane, mitochondrion	molecular_function, thiosulfate sulfurtransferase activity, transferase activity		
YOR286W	RDL2	Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000005812]	biological_process	mitochondrion	thiosulfate sulfurtransferase activity, transferase activity		
YOR287C	RRP36	Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit [Source:SGD;Acc:S000005813]	cleavage involved in rRNA processing, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis	90S preribosome, nucleolus, nucleus, ribonucleoprotein complex	molecular_function		
YOR288C	MPD1	Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation [Source:SGD;Acc:S000005814]	cell redox homeostasis, protein folding	endoplasmic reticulum, endoplasmic reticulum lumen, fungal-type vacuole	isomerase activity, protein disulfide isomerase activity, protein disulfide oxidoreductase activity		
YOR289W	YOR289W	Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000005815]	biological_process	cytoplasm, nucleus	molecular_function		
YOR290C	SNF2	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p [Source:SGD;Acc:S000005816]	ATP-dependent chromatin remodeling, double-strand break repair, nucleosome mobilization, positive regulation of transcription, DNA-dependent	SWI/SNF complex, nucleus	ATP binding, DNA binding, DNA-dependent ATPase activity, helicase activity, histone acetyl-lysine binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, nucleic acid binding, nucleotide binding, protein binding		
YOR291W	YPK9	Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome [Source:SGD;Acc:S000005817]	ATP biosynthetic process, biological_process, cation transport, metabolic process	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, metal ion binding, molecular_function, nucleotide binding		
YOR292C	YOR292C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene [Source:SGD;Acc:S000005818]	biological_process	fungal-type vacuole, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YOR293C-A	YOR293C-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028858]	biological_process	cellular_component	molecular_function		
YOR293W	RPS10A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10 [Source:SGD;Acc:S000005819]	rRNA export from nucleus, translation	cytoplasm, cytosolic small ribosomal subunit, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOR294W	RRS1	Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice [Source:SGD;Acc:S000005820]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal large subunit biogenesis, ribosomal large subunit export from nucleus, ribosome biogenesis	nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor	molecular_function		
YOR295W	UAF30	Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate [Source:SGD;Acc:S000005821]	transcription from RNA polymerase I promoter	RNA polymerase I upstream activating factor complex, nucleolus, nucleus	protein binding, rDNA binding		
YOR296W	YOR296W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene [Source:SGD;Acc:S000005822]	biological_process	cytoplasm	molecular_function, protein binding		
YOR297C	TIM18	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex [Source:SGD;Acc:S000005823]	apoptosis, cellular response to oxidative stress, protein import into mitochondrial inner membrane, protein transport, response to acid, response to arsenic-containing substance, response to osmotic stress, transmembrane transport, transport, tricarboxylic acid cycle	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial inner membrane protein insertion complex, mitochondrion	heme binding, iron ion binding, protein channel activity		
YOR298C-A	MBF1	Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations [Source:SGD;Acc:S000007253]	positive regulation of transcription from RNA polymerase II promoter	cytoplasm, mitochondrion, nucleus	DNA binding, sequence-specific DNA binding, transcription coactivator activity		
YOR298W	MUM3	Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases [Source:SGD;Acc:S000005824]	ascospore wall assembly, metabolic process, phospholipid biosynthetic process, sporulation resulting in formation of a cellular spore	cellular_component, integral to membrane, membrane	acyltransferase activity		
YOR299W	BUD7	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane [Source:SGD;Acc:S000005825]	Golgi to plasma membrane transport, cellular bud site selection, fungal-type cell wall chitin biosynthetic process, protein transport, transport	Golgi apparatus, clathrin-coated vesicle, exomer complex, membrane, trans-Golgi network transport vesicle	binding, molecular_function		
YOR300W	YOR300W	Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 [Source:SGD;Acc:S000005826]					
YOR301W	RAX1	Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily [Source:SGD;Acc:S000005827]	cell cycle, cell division, cellular bud site selection	cellular bud neck, cellular bud tip, integral to membrane, membrane, plasma membrane	molecular_function, signal transducer activity		
YOR302W	YOR302W	CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA [Source:SGD;Acc:S000005828]	regulation of translation	cytosol	translation regulator activity		
YOR303W	CPA1	Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader [Source:SGD;Acc:S000005829]	arginine biosynthetic process, cellular amino acid biosynthetic process, glutamine metabolic process, nitrogen compound metabolic process	carbamoyl-phosphate synthase complex, cytoplasm	ATP binding, carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, carbamoyl-phosphate synthase activity, catalytic activity, ligase activity, nucleotide binding		
YOR304C-A	YOR304C-A	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck [Source:SGD;Acc:S000005830]	biological_process	cellular bud, cellular bud neck, cytoplasm, mating projection tip	molecular_function		
YOR304W	ISW2	ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth [Source:SGD;Acc:S000005831]	ATP-dependent chromatin remodeling, chromatin modification, chromatin remodeling, chromatin silencing at rDNA, chromatin silencing at telomere, negative regulation of antisense RNA transcription, negative regulation of transcription from RNA polymerase II promoter by pheromones, nucleosome positioning	chromatin accessibility complex, chromatin remodeling complex, nucleus	ATP binding, DNA binding, DNA translocase activity, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, nucleic acid binding, nucleosome binding, nucleotide binding, protein binding, single-stranded DNA binding		
YOR305W	RRG7	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene [Source:SGD;Acc:S000005832]	biological_process	mitochondrion	molecular_function		
YOR306C	MCH5	Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport [Source:SGD;Acc:S000005833]	riboflavin transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	riboflavin transporter activity		
YOR307C	SLY41	Protein involved in ER-to-Golgi transport [Source:SGD;Acc:S000005834]	ER to Golgi vesicle-mediated transport, transport	endoplasmic reticulum, integral to membrane, membrane	molecular_function, transporter activity		
YOR308C	SNU66	Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 [Source:SGD;Acc:S000005835]	RNA splicing, mRNA processing, maturation of 5S rRNA, nuclear mRNA splicing, via spliceosome	U4/U6 x U5 tri-snRNP complex, nucleus, ribonucleoprotein complex, spliceosomal complex	molecular_function		
YOR309C	YOR309C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 [Source:SGD;Acc:S000005836]					
YOR310C	NOP58	Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA [Source:SGD;Acc:S000005837]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	90S preribosome, box C/D snoRNP complex, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	molecular_function		
YOR311C	DGK1	Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain [Source:SGD;Acc:S000005838]	phosphatidic acid biosynthetic process, transport, vesicle-mediated transport	Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, nuclear membrane, nucleus	diacylglycerol kinase activity, kinase activity, phosphotransferase activity, alcohol group as acceptor, transferase activity, transferase activity, transferring phosphorus-containing groups		
YOR312C	RPL20B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein [Source:SGD;Acc:S000005839]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOR313C	SPS4	Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage [Source:SGD;Acc:S000005840]	ascospore formation, meiosis, sporulation resulting in formation of a cellular spore	cellular_component	molecular_function		
YOR314W	YOR314W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005841]					
YOR314W-A	YOR314W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007629]					
YOR315W	SFG1	Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate [Source:SGD;Acc:S000005842]	positive regulation of transcription from RNA polymerase II promoter, pseudohyphal growth	cytoplasm, nucleus			
YOR316C	COT1	Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium [Source:SGD;Acc:S000005843]	cation transport, cellular zinc ion homeostasis, cobalt ion transport, transmembrane transport, transport, zinc ion transport	fungal-type vacuole, integral to membrane, membrane, mitochondrial membrane, mitochondrion	cation transmembrane transporter activity, cobalt ion transmembrane transporter activity, inorganic cation transmembrane transporter activity, zinc ion transmembrane transporter activity		
YOR316C-A	YOR316C-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028584]	biological_process	cellular_component	molecular_function		
YOR317W	FAA1	Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles [Source:SGD;Acc:S000005844]	fatty acid metabolic process, lipid metabolic process, long-chain fatty acid transport, long-chain fatty-acyl-CoA metabolic process, metabolic process	lipid particle, mitochondrial outer membrane, mitochondrion, plasma membrane enriched fraction	ATP binding, catalytic activity, ligase activity, long-chain fatty acid-CoA ligase activity, nucleotide binding		
YOR318C	YOR318C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo [Source:SGD;Acc:S000005845]					
YOR319W	HSH49	U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) [Source:SGD;Acc:S000005846]	mRNA processing, nuclear mRNA splicing, via spliceosome	U2 snRNP, U2-type prespliceosome, nucleus	RNA binding, nucleic acid binding, nucleotide binding		
YOR320C	GNT1	N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus [Source:SGD;Acc:S000005847]	protein N-linked glycosylation	Golgi apparatus, Golgi medial cisterna, Golgi membrane, integral to membrane, membrane, vacuolar membrane, vacuole	acetylglucosaminyltransferase activity, transferase activity		
YOR321W	PMT3	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals [Source:SGD;Acc:S000005848]	protein O-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity, mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YOR322C	LDB19	Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; localization changes in response to nutrient levels; null mutant has reduced affinity for alcian blue dye [Source:SGD;Acc:S000005849]	cell cycle, ubiquitin-dependent endocytosis	Golgi apparatus, clathrin-coated vesicle, cytoplasm	ubiquitin protein ligase binding		
YOR323C	PRO2	Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis [Source:SGD;Acc:S000005850]	cellular amino acid biosynthetic process, metabolic process, oxidation-reduction process, proline biosynthetic process	cytoplasm, nucleus	NADP binding, glutamate-5-semialdehyde dehydrogenase activity, oxidoreductase activity		
YOR324C	FRT1	Tail-anchored ER membrane protein that is a substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation [Source:SGD;Acc:S000005851]	response to stress	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YOR325W	YOR325W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 [Source:SGD;Acc:S000005852]					
YOR326W	MYO2	One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle [Source:SGD;Acc:S000005853]	Golgi inheritance, budding cell apical bud growth, cell cycle, cell division, establishment of mitotic spindle orientation, membrane addition at site of cytokinesis, mitochondrion inheritance, peroxisome inheritance, protein transport, transport, unidimensional cell growth, vacuole inheritance, vesicle transport along actin filament, vesicle-mediated transport	actin filament bundle, cellular bud neck, cellular bud tip, filamentous actin, fungal-type vacuole membrane, incipient cellular bud site, mating projection tip, myosin V complex, myosin complex, vesicle	ATP binding, actin binding, actin filament binding, calmodulin binding, microfilament motor activity, motor activity, nucleotide binding, protein binding		
YOR327C	SNC2	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins [Source:SGD;Acc:S000005854]	Golgi to plasma membrane transport, endocytosis, vesicle fusion, vesicle-mediated transport	endomembrane system, endosome, integral to membrane, membrane, trans-Golgi network, transport vesicle	SNAP receptor activity		
YOR328W	PDR10	ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p [Source:SGD;Acc:S000005855]	drug transmembrane transport, transport	integral to membrane, membrane, plasma membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YOR329C	SCD5	Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency [Source:SGD;Acc:S000005856]	actin filament organization, cortical actin cytoskeleton organization, endocytosis, protein secretion, protein transport, transport	actin cortical patch, membrane, nucleus, peripheral to membrane of membrane fraction	protein phosphatase 1 binding		
YOR329W-A	YOR329W-A	Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028585]					
YOR330C	MIP1	Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; related to human POLG, which has been associated with mitochondrial diseases [Source:SGD;Acc:S000005857]	DNA replication, DNA-dependent DNA replication, mitochondrial DNA replication	gamma DNA polymerase complex, mitochondrion	3'-5' exonuclease activity, DNA binding, DNA-directed DNA polymerase activity, nucleic acid binding, nucleotidyltransferase activity, transferase activity		
YOR331C	YOR331C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W [Source:SGD;Acc:S000005858]					
YOR332W	VMA4	Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane [Source:SGD;Acc:S000005859]	ATP synthesis coupled proton transport, ion transport, proton transport, transport, vacuolar acidification	fungal-type vacuole membrane, membrane, proton-transporting two-sector ATPase complex, catalytic domain, vacuolar membrane, vacuolar proton-transporting V-type ATPase, V1 domain, vacuole	proton-transporting ATPase activity, rotational mechanism		
YOR333C	YOR333C	Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth [Source:SGD;Acc:S000005860]					
YOR334W	MRS2	Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns [Source:SGD;Acc:S000005861]	ion transport, mitochondrial magnesium ion transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	magnesium ion transmembrane transporter activity		
YOR335C	ALA1	Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog [Source:SGD;Acc:S000005862]	alanyl-tRNA aminoacylation, mitochondrial alanyl-tRNA aminoacylation, tRNA aminoacylation, translation	cytoplasm, mitochondrion	ATP binding, RNA binding, alanine-tRNA ligase activity, aminoacyl-tRNA ligase activity, ligase activity, ligase activity, forming aminoacyl-tRNA and related compounds, metal ion binding, nucleic acid binding, nucleotide binding, tRNA binding		
YOR335W-A	YOR335W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ALA1/YOR335C [Source:SGD;Acc:S000028717]					
YOR336W	KRE5	Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects [Source:SGD;Acc:S000005863]	1,6-beta-glucan biosynthetic process, cellular cell wall organization, protein glycosylation	endoplasmic reticulum, endoplasmic reticulum lumen	UDP-glucose:glycoprotein glucosyltransferase activity		
YOR337W	TEA1	Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein [Source:SGD;Acc:S000005864]	regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YOR338W	YOR338W	Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen [Source:SGD;Acc:S000005865]	ascospore formation, positive regulation of transcription from RNA polymerase II promoter, response to stress	cellular_component	molecular_function, protein binding		
YOR339C	UBC11	Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2 [Source:SGD;Acc:S000005866]	post-translational protein modification, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of protein metabolic process	cytoplasm	ATP binding, acid-amino acid ligase activity, ligase activity, nucleotide binding, small conjugating protein ligase activity, ubiquitin-protein ligase activity		
YOR340C	RPA43	RNA polymerase I subunit A43 [Source:SGD;Acc:S000005867]	transcription of nuclear rRNA large RNA polymerase I transcript	DNA-directed RNA polymerase I complex, nucleolus, nucleus	DNA-directed RNA polymerase activity		
YOR341W	RPA190	RNA polymerase I largest subunit A190 [Source:SGD;Acc:S000005868]	transcription of nuclear rRNA large RNA polymerase I transcript	DNA-directed RNA polymerase I complex, nucleolus, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding, nucleotidyltransferase activity, transferase activity, zinc ion binding		
YOR342C	YOR342C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus [Source:SGD;Acc:S000005869]	biological_process	cytoplasm, nucleus	molecular_function		
YOR343C	YOR343C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005870]					
YOR343W-A	YOR343W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007355]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YOR343W-B	YOR343W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007356]	DNA integration, DNA recombination, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YOR344C	TYE7	Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression [Source:SGD;Acc:S000005871]	positive regulation of glycolysis	nuclear chromatin, nucleus	DNA binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YOR345C	YOR345C	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 [Source:SGD;Acc:S000005872]					
YOR346W	REV1	Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA [Source:SGD;Acc:S000005873]	DNA repair, DNA replication, error-free translesion synthesis, error-prone translesion synthesis, response to DNA damage stimulus	intracellular, mitochondrion, nuclear chromatin, nucleus, replication fork	DNA binding, DNA-directed DNA polymerase activity, damaged DNA binding, deoxycytidyl transferase activity, magnesium ion binding, metal ion binding, nucleotidyltransferase activity, transferase activity		
YOR347C	PYK2	Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux [Source:SGD;Acc:S000005874]	glycolysis, pyruvate metabolic process	cytosol, mitochondrion	ATP binding, catalytic activity, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, potassium ion binding, pyruvate kinase activity, transferase activity		
YOR348C	PUT4	Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells [Source:SGD;Acc:S000005875]	amino acid transport, ammonia assimilation cycle, gamma-aminobutyric acid transport, neutral amino acid transport, proline catabolic process, proline metabolic process, proline transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	L-proline transmembrane transporter activity, amino acid transmembrane transporter activity, neutral amino acid transmembrane transporter activity		
YOR349W	CIN1	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl [Source:SGD;Acc:S000005876]	protein folding	cellular_component	beta-tubulin binding, binding		
YOR350C	MNE1	Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA [Source:SGD;Acc:S000005877]	Group I intron splicing	mitochondrial matrix, mitochondrion, ribonucleoprotein complex	molecular_function		
YOR351C	MEK1	Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids [Source:SGD;Acc:S000005878]	meiosis, meiotic recombination checkpoint, protein phosphorylation	nucleus	ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YOR352W	YOR352W	Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000005879]	biological_process	cytoplasm, nucleus	molecular_function		
YOR353C	SOG2	Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis [Source:SGD;Acc:S000005880]	budding cell apical bud growth, cell cycle, cell division, cytokinetic cell separation, signal transduction	cellular bud, cytoplasm, incipient cellular bud site, mating projection tip	molecular_function, protein binding		
YOR354C	MSC6	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005881]	DNA recombination, meiosis, reciprocal meiotic recombination	mitochondrion	molecular_function		
YOR355W	GDS1	Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005882]	aerobic respiration	cytoplasm, mitochondrion, nucleus	molecular_function		
YOR356W	CIR2	Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response [Source:SGD;Acc:S000005883]	biological_process, electron transport chain, oxidation-reduction process, transport	membrane, mitochondrial inner membrane, mitochondrion	4 iron, 4 sulfur cluster binding, electron-transferring-flavoprotein dehydrogenase activity, iron-sulfur cluster binding, metal ion binding, molecular_function, oxidoreductase activity		
YOR357C	SNX3	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p [Source:SGD;Acc:S000005884]	cell communication, late endosome to Golgi transport, protein localization, protein transport, transport	Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endosome, late endosome membrane, membrane	phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding		
YOR358W	HAP5	Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex [Source:SGD;Acc:S000005885]	regulation of carbohydrate metabolic process	CCAAT-binding factor complex, nucleus	DNA binding		
YOR359W	VTS1	Post-transcriptional gene regulator, flap-structured DNA-binding and RNA-binding protein; shows genetic interactions with Vti1p, a v-SNARE involved in cis-Golgi membrane traffic; stimulates Dna2p endonuclease activity; contains a SAM domain [Source:SGD;Acc:S000005886]	nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of endodeoxyribonuclease activity, protein transport, transport	cytoplasm, cytoplasmic mRNA processing body, cytosol, nucleus	RNA binding, flap-structured DNA binding, nucleotide binding, protein binding		
YOR360C	PDE2	High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon [Source:SGD;Acc:S000005887]	cAMP-mediated signaling, signal transduction	cytoplasm, nucleus	3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, catalytic activity, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity		
YOR361C	PRT1	eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes [Source:SGD;Acc:S000005888]	translation, translational initiation	cytoplasm, eukaryotic translation initiation factor 3 complex, multi-eIF complex, stress granule	RNA binding, nucleic acid binding, nucleotide binding, translation initiation factor activity		
YOR362C	PRE10	Alpha 7 subunit of the 20S proteasome [Source:SGD;Acc:S000005889]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteolysis involved in cellular protein catabolic process, ubiquitin-dependent protein catabolic process	cytoplasm, mitochondrion, nuclear outer membrane-endoplasmic reticulum membrane network, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, molecular_function, peptidase activity, threonine-type endopeptidase activity		
YOR363C	PIP2	Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes [Source:SGD;Acc:S000005890]	fatty acid metabolic process, peroxisome organization, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YOR364W	YOR364W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C [Source:SGD;Acc:S000005891]					
YOR365C	YOR365C	Putative protein of unknown function; YOR365C is not an essential protein [Source:SGD;Acc:S000005892]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR366W	YOR366W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C [Source:SGD;Acc:S000005893]					
YOR367W	SCP1	Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin [Source:SGD;Acc:S000005894]	actin filament organization, chronological cell aging	actin cortical patch, cytoplasm, cytoskeleton	actin filament binding, protein binding, protein binding, bridging		
YOR368W	RAD17	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins [Source:SGD;Acc:S000005895]	DNA damage checkpoint, DNA repair, double-strand break repair, reciprocal meiotic recombination, response to DNA damage stimulus	checkpoint clamp complex, nucleus	DNA binding, damaged DNA binding, double-stranded DNA binding, exodeoxyribonuclease III activity, exonuclease activity, hydrolase activity, nuclease activity		
YOR369C	RPS12	Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12 [Source:SGD;Acc:S000005896]	translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YOR370C	MRS6	Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene [Source:SGD;Acc:S000005897]	ER to Golgi vesicle-mediated transport, activation of Rab GTPase activity, intracellular protein transport, protein geranylgeranylation, protein targeting to membrane, regulation of GTPase activity	Rab-protein geranylgeranyltransferase complex, cytoplasm, membrane	GTPase activator activity, Rab GTPase binding, Rab geranylgeranyltransferase activity		
YOR371C	GPB1	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p [Source:SGD;Acc:S000005898]	glucose mediated signaling pathway, invasive growth in response to glucose limitation, negative regulation of Ras protein signal transduction, negative regulation of phosphorylation, positive regulation of Ras protein signal transduction, protein polyubiquitination, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, pseudohyphal growth, signal transduction	cytoplasm, plasma membrane	GTPase activating protein binding, cAMP-dependent protein kinase inhibitor activity, signal transducer activity		
YOR372C	NDD1	Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes [Source:SGD;Acc:S000005899]	positive regulation of transcription involved in G2/M-phase of mitotic cell cycle	cytoplasm, nucleus	transcription coactivator activity		
YOR373W	NUD1	Component of the spindle pole body outer plaque, required for exit from mitosis [Source:SGD;Acc:S000005900]	cell cycle, cell division, exit from mitosis, meiosis, meiotic chromosome segregation, mitosis	cytoplasm, cytoskeleton, nuclear envelope, nucleus, spindle pole body	protein binding, structural constituent of cytoskeleton		
YOR374W	ALD4	Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed [Source:SGD;Acc:S000005901]	NADPH regeneration, acetate biosynthetic process, ethanol metabolic process, metabolic process, oxidation-reduction process, pyruvate metabolic process	mitochondrial matrix, mitochondrial nucleoid, mitochondrion	aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity, oxidoreductase activity		
YOR375C	GDH1	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources [Source:SGD;Acc:S000005902]	ammonia assimilation cycle, cellular amino acid metabolic process, glutamate biosynthetic process, metabolic process, oxidation-reduction process	cytoplasm, nucleus, soluble fraction	binding, catalytic activity, glutamate dehydrogenase (NADP+) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor		
YOR376W	YOR376W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene. [Source:SGD;Acc:S000005903]					
YOR376W-A	YOR376W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028586]	biological_process	cellular_component	molecular_function		
YOR377W	ATF1	Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation [Source:SGD;Acc:S000005904]	acetate derivative biosynthetic process, alcohol metabolic process, fatty acid metabolic process, fermentation	endomembrane system, lipid particle, membrane	acyltransferase activity, alcohol O-acetyltransferase activity, transferase activity		
YOR378W	YOR378W	Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene [Source:SGD;Acc:S000005905]	biological_process, transmembrane transport, transport	cellular_component, integral to membrane, membrane, plasma membrane	molecular_function		
YOR379C	YOR379C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W [Source:SGD;Acc:S000005906]					
YOR380W	RDR1	Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins [Source:SGD;Acc:S000005907]	regulation of transcription, DNA-dependent, response to xenobiotic stimulus	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YOR381W	FRE3	Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels [Source:SGD;Acc:S000005908]	cellular iron ion homeostasis, electron transport chain, ion transport, iron ion transport, oxidation-reduction process, siderophore transport, transport	integral to membrane, membrane, plasma membrane	electron carrier activity, ferric-chelate reductase activity, flavin adenine dinucleotide binding, iron ion binding, metal ion binding, oxidoreductase activity		
YOR381W-A	YOR381W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028587]	biological_process	cellular_component	molecular_function		
YOR382W	FIT2	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall [Source:SGD;Acc:S000005909]	ion transport, iron ion transport, siderophore transport, transport	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YOR383C	FIT3	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall [Source:SGD;Acc:S000005910]	ion transport, iron ion transport, siderophore transport, transport	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane	molecular_function		
YOR384W	FRE5	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005911]	biological_process, electron transport chain, ion transport, oxidation-reduction process, transport	integral to membrane, membrane, mitochondrion, plasma membrane	electron carrier activity, ferric-chelate reductase activity, flavin adenine dinucleotide binding, iron ion binding, metal ion binding, oxidoreductase activity		
YOR385W	YOR385W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene [Source:SGD;Acc:S000005912]	biological_process	cytoplasm	molecular_function		
YOR386W	PHR1	DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p [Source:SGD;Acc:S000005913]	DNA repair, photoreactive repair, protein-chromophore linkage, response to DNA damage stimulus	mitochondrion, nucleus	DNA binding, DNA photolyase activity, deoxyribodipyrimidine photo-lyase activity, lyase activity, nucleotide binding		
YOR387C	YOR387C	Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction [Source:SGD;Acc:S000005914]	biological_process	cytoplasm, cytosol, soluble fraction	molecular_function		
YOR388C	FDH1	NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate [Source:SGD;Acc:S000005915]	NADH regeneration, formate catabolic process, metabolic process, oxidation-reduction process	cytoplasm, cytosol	NAD binding, binding, catalytic activity, cofactor binding, formate dehydrogenase (NAD+) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YOR389W	YOR389W	Putative protein of unknown function; expression regulated by copper levels [Source:SGD;Acc:S000005916]	biological_process	cellular_component, extracellular region	molecular_function		
YOR390W	YOR390W	Putative protein of unknown function [Source:SGD;Acc:S000005917]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YOR391C	HSP33	Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease [Source:SGD;Acc:S000005918]	biological_process, response to stress	cellular_component	cysteine-type peptidase activity, hydrolase activity, peptidase activity, unfolded protein binding		
YOR392W	YOR392W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat [Source:SGD;Acc:S000005919]					
YOR393W	ERR1	Protein of unknown function, has similarity to enolases [Source:SGD;Acc:S000005920]	biological_process, glycolysis	cellular_component, phosphopyruvate hydratase complex	lyase activity, magnesium ion binding, metal ion binding, phosphopyruvate hydratase activity		
YOR394C-A	YOR394C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028718]	biological_process	cellular_component	molecular_function		
YOR394W	PAU21	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau22p; encodes 2 proteins that are translated from 2 different start codons [Source:SGD;Acc:S000005921]	biological_process, response to stress	cellular_component	molecular_function		
YOR396C-A	YOR396C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028719]					
YOR396W	YRF1-8	One of several telomeric Y' element-encoded DNA helicases, known as Y'-Help1 (Y'-HELicase Protein 1) [Source:SGD;Acc:S000007526]	biological_process	cellular_component	ATP binding, ATP-dependent helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YPL001W	HAT1	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair [Source:SGD;Acc:S000005922]	DNA repair, chromatin modification, chromatin silencing at telomere, histone acetylation, metabolic process, response to DNA damage stimulus	cytoplasm, histone acetyltransferase complex, nucleus	N-acetyltransferase activity, acyltransferase activity, histone acetyltransferase activity, histone binding, transferase activity		
YPL002C	SNF8	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression [Source:SGD;Acc:S000005923]	negative regulation of transcription from RNA polymerase II promoter by glucose, protein targeting to vacuole, protein transport, transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ESCRT II complex, cytoplasm, endosome, endosome membrane, membrane			
YPL003W	ULA1	Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation [Source:SGD;Acc:S000005924]	metabolic process, protein neddylation	cellular_component	ATP binding, NEDD8 activating enzyme activity, binding, catalytic activity, nucleotide binding		
YPL004C	LSP1	Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways [Source:SGD;Acc:S000005925]	endocytosis, negative regulation of protein kinase activity, response to heat	cell cortex, cytoplasm, eisosome, mitochondrial outer membrane, mitochondrion, plasma membrane enriched fraction	molecular_function		
YPL005W	AEP3	Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex [Source:SGD;Acc:S000005926]	mRNA metabolic process	cytoplasm, extrinsic to membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YPL006W	NCR1	Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein [Source:SGD;Acc:S000005927]	lipid metabolic process, lipid transport, sphingolipid metabolic process, transport	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	hedgehog receptor activity, sphingolipid transporter activity		
YPL007C	TFC8	One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 [Source:SGD;Acc:S000005928]	transcription initiation from RNA polymerase III promoter	nucleus, transcription factor TFIIIC complex	DNA binding, protein binding		
YPL008W	CHL1	Probable DNA helicase involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member [Source:SGD;Acc:S000005929]	cell cycle, chromosome segregation, donor selection, mitotic sister chromatid cohesion, negative regulation of DNA recombination, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	nucleus	ATP binding, ATP-dependent DNA helicase activity, ATP-dependent helicase activity, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, nucleic acid binding, nucleotide binding		
YPL009C	TAE2	Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000005930]	translation	cytoplasm, ribosome	molecular_function		
YPL010W	RET3	Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER [Source:SGD;Acc:S000005931]	protein transport, retrograde vesicle-mediated transport, Golgi to ER, transport, vesicle-mediated transport	COPI coated vesicle membrane, COPI vesicle coat, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, membrane			
YPL011C	TAF3	TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation [Source:SGD;Acc:S000005932]	RNA polymerase II transcriptional preinitiation complex assembly	nucleus, transcription factor TFIID complex	chromatin binding		
YPL012W	RRP12	Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats [Source:SGD;Acc:S000005933]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosome biogenesis	90S preribosome, cytoplasm, nucleolus, nucleus, ribosome	RNA binding, binding, molecular_function		
YPL013C	MRPS16	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000005934]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YPL014W	YPL014W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus [Source:SGD;Acc:S000005935]	biological_process	cytoplasm, nucleus	molecular_function		
YPL015C	HST2	Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro [Source:SGD;Acc:S000005936]	chromatin silencing, chromatin silencing at rDNA, chronological cell aging, negative regulation of chromatin silencing at telomere, negative regulation of mitotic recombination, protein deacetylation	cytoplasm, nucleus	NAD binding, NAD+ binding, NAD-dependent histone deacetylase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, metal ion binding, zinc ion binding		
YPL016W	SWI1	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+] [Source:SGD;Acc:S000005937]	ATP-dependent chromatin remodeling, nucleosome mobilization, positive regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter	SWI/SNF complex, intracellular, nucleus	DNA binding, metal ion binding		
YPL017C	IRC15	Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci [Source:SGD;Acc:S000005938]	attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation, cell redox homeostasis, meiotic sister chromatid segregation, metabolic process, microtubule anchoring, microtubule nucleation, mitotic recombination, oxidation-reduction process, positive regulation of mitotic cell cycle	cytoplasm, microtubule	S-adenosylmethionine-dependent methyltransferase activity, binding, catalytic activity, dihydrolipoyl dehydrogenase activity, flavin adenine dinucleotide binding, microtubule binding, oxidoreductase activity		
YPL018W	CTF19	Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly [Source:SGD;Acc:S000005939]	attachment of spindle microtubules to kinetochore, cell cycle, cell division, chromosome segregation, establishment of mitotic sister chromatid cohesion, meiosis, mitosis	COMA complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, kinetochore, nucleus	molecular_function		
YPL019C	VTC3	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion [Source:SGD;Acc:S000005940]	microautophagy, polyphosphate metabolic process, vacuolar transport, vacuole fusion, non-autophagic	endoplasmic reticulum, integral to membrane, membrane, vacuolar membrane, vacuolar transporter chaperone complex, vacuole	molecular_function		
YPL020C	ULP1	Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions [Source:SGD;Acc:S000005941]	G2/M transition of mitotic cell cycle, protein desumoylation, proteolysis	nuclear envelope, nuclear pore, nucleolus	SUMO-specific protease activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity		
YPL021W	ECM23	Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p [Source:SGD;Acc:S000005942]	cellular cell wall organization, pseudohyphal growth, regulation of transcription, DNA-dependent	cellular_component	metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YPL022W	RAD1	Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein [Source:SGD;Acc:S000005943]	DNA metabolic process, DNA repair, double-strand break repair via single-strand annealing, removal of nonhomologous ends, meiotic mismatch repair, mitotic recombination, nucleotide-excision repair, DNA incision, 5'-to lesion, removal of nonhomologous ends, response to DNA damage stimulus	nucleotide-excision repair factor 1 complex, nucleus	DNA binding, endonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, single-stranded DNA binding, single-stranded DNA specific endodeoxyribonuclease activity		
YPL023C	MET12	Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR [Source:SGD;Acc:S000005944]	biological_process, methionine metabolic process, oxidation-reduction process	cellular_component	methylenetetrahydrofolate reductase (NADPH) activity, oxidoreductase activity		
YPL024W	RMI1	Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing and ssDNA binding activities of Top3p; involved in response to DNA damage; null mutants display increased rates of recombination and delayed S phase [Source:SGD;Acc:S000005945]	cell cycle, cell division, meiosis, mitotic sister chromatid cohesion, positive regulation of DNA binding, response to DNA damage stimulus	RecQ helicase-Topo III complex, cytoplasm, nucleus	DNA binding, enzyme activator activity, four-way junction DNA binding, single-stranded DNA binding		
YPL025C	YPL025C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005946]					
YPL026C	SKS1	Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway [Source:SGD;Acc:S000005947]	glucose transport, positive regulation of transcription from RNA polymerase II promoter, protein phosphorylation, response to glucose stimulus	cytoplasm, nucleus	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPL027W	SMA1	Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p [Source:SGD;Acc:S000005948]	ascospore-type prospore membrane assembly, sporulation resulting in formation of a cellular spore	prospore membrane	molecular_function		
YPL028W	ERG10	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis [Source:SGD;Acc:S000005949]	ergosterol biosynthetic process, metabolic process	cytoplasm, cytosol	acetyl-CoA C-acetyltransferase activity, acyltransferase activity, catalytic activity, metal ion binding, transferase activity, transferase activity, transferring acyl groups other than amino-acyl groups		
YPL029W	SUV3	ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron [Source:SGD;Acc:S000005950]	Group I intron splicing, RNA catabolic process	mitochondrial matrix, mitochondrion	ATP binding, ATP-dependent RNA helicase activity, RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YPL030W	TRM44	tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene [Source:SGD;Acc:S000005951]	tRNA methylation, tRNA processing	cytoplasm	methyltransferase activity, tRNA (uracil) methyltransferase activity, transferase activity		
YPL031C	PHO85	Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle [Source:SGD;Acc:S000005952]	fungal-type cell wall organization, negative regulation of calcium-mediated signaling, negative regulation of glycogen biosynthetic process, negative regulation of macroautophagy, negative regulation of phosphate metabolic process, negative regulation of sequence-specific DNA binding transcription factor activity, negative regulation of transcription from RNA polymerase II promoter, positive regulation of macroautophagy, protein phosphorylation, regulation of establishment or maintenance of cell polarity, regulation of protein localization, regulation of protein stability, regulation of transcription involved in G1/S phase of mitotic cell cycle, response to DNA damage stimulus	cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus	ATP binding, cyclin-dependent protein kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPL032C	SVL3	Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck [Source:SGD;Acc:S000005953]	endocytosis, oxidation-reduction process	cell cortex, cellular bud, cellular bud neck, cytoplasm	NADP binding, coenzyme binding, molecular_function, oxidoreductase activity		
YPL033C	SRL4	Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p [Source:SGD;Acc:S000005954]	deoxyribonucleoside triphosphate metabolic process, metabolic process	cellular_component	binding, catalytic activity, molecular_function, oxidoreductase activity		
YPL034W	YPL034W	Putative protein of unknown function; YPL034W is not essential gene [Source:SGD;Acc:S000005955]	biological_process	cellular_component	molecular_function		
YPL035C	YPL035C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene [Source:SGD;Acc:S000005956]					
YPL036W	PMA2	Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential [Source:SGD;Acc:S000005957]	ATP biosynthetic process, cation transport, ion transport, metabolic process, proton transport, regulation of pH, transport	integral to membrane, membrane, mitochondrion, plasma membrane, plasma membrane enriched fraction	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism, catalytic activity, hydrogen-exporting ATPase activity, phosphorylative mechanism, hydrolase activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, metal ion binding, nucleotide binding		
YPL037C	EGD1	Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b [Source:SGD;Acc:S000005958]	'de novo' cotranslational protein folding, protein transport, transport	cytoplasm, nascent polypeptide-associated complex, nucleus	unfolded protein binding		
YPL038W	MET31	Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met32p [Source:SGD;Acc:S000005959]	sulfur amino acid metabolic process	cytoplasm, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YPL038W-A	YPL038W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028588]	biological_process	cellular_component	molecular_function		
YPL039W	YPL039W	Putative protein of unknown function; YPL039W is not an essential gene [Source:SGD;Acc:S000005960]	biological_process	cellular_component	molecular_function		
YPL040C	ISM1	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth [Source:SGD;Acc:S000005961]	isoleucyl-tRNA aminoacylation, mitochondrial isoleucyl-tRNA aminoacylation, mitochondrial translation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, isoleucine-tRNA ligase activity, ligase activity, nucleotide binding, zinc ion binding		
YPL041C	YPL041C	Protein of unknown function involved in maintenance of proper telomere length [Source:SGD;Acc:S000005962]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YPL042C	SSN3	Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression [Source:SGD;Acc:S000005963]	meiosis, negative regulation of filamentous growth, negative regulation of transcription from RNA polymerase II promoter, nuclear-transcribed mRNA catabolic process, non-stop decay, phosphorylation of RNA polymerase II C-terminal domain, positive regulation of transcription from RNA polymerase II promoter by galactose, protein destabilization, protein phosphorylation	mediator complex, nucleus	ATP binding, RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein kinase activity, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPL043W	NOP4	Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) [Source:SGD;Acc:S000005964]	rRNA processing, ribosome biogenesis	nucleolus, nucleus	RNA binding, nucleic acid binding, nucleotide binding		
YPL044C	YPL044C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W [Source:SGD;Acc:S000005965]					
YPL045W	VPS16	Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages [Source:SGD;Acc:S000005966]	Golgi to endosome transport, intracellular protein transport, late endosome to vacuole transport, protein targeting to vacuole, protein transport, regulation of SNARE complex assembly, regulation of vacuole fusion, non-autophagic, transport, vacuole fusion, non-autophagic, vacuole organization	CORVET complex, HOPS complex, cytoplasm, fungal-type vacuole membrane, vacuole	phosphatidylinositol binding		
YPL046C	ELC1	Elongin C, involved in transcription elongation as a heterodimer with Ela1p; required for ubiquitin-dependent degradation of Rpo21p; plays a role in global genomic nucleotide excision repair; expression highly upregulated during sporulation [Source:SGD;Acc:S000005967]	nucleotide-excision repair, DNA damage recognition, protein ubiquitination involved in ubiquitin-dependent protein catabolic process, transcription elongation from RNA polymerase II promoter, ubiquitin-dependent protein catabolic process	Cul3-RING ubiquitin ligase complex, cytoplasm, nucleotide-excision repair factor 4 complex, nucleus, transcription elongation factor complex	ubiquitin-protein ligase activity		
YPL047W	SGF11	Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation [Source:SGD;Acc:S000005968]	chromatin modification, histone deubiquitination, regulation of transcription from RNA polymerase II promoter	DUBm complex, SAGA complex, nucleus	enzyme activator activity, metal ion binding		
YPL048W	CAM1	Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma [Source:SGD;Acc:S000005969]	positive regulation of transcription from RNA polymerase II promoter, ribosome biogenesis, translation, translational elongation	cytoplasm, eukaryotic translation elongation factor 1 complex, nucleus	calcium ion binding, phospholipid binding, protein binding, transcription coactivator activity, translation elongation factor activity		
YPL049C	DIG1	MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p [Source:SGD;Acc:S000005970]	negative regulation of invasive growth in response to glucose limitation, negative regulation of pseudohyphal growth, negative regulation of transcription from RNA polymerase II promoter by pheromones	nucleus	DNA binding, transcription factor binding		
YPL050C	MNN9	Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation [Source:SGD;Acc:S000005971]	barrier septum formation, protein N-linked glycosylation	Golgi apparatus, Golgi membrane, alpha-1,6-mannosyltransferase complex, cis-Golgi network, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	alpha-1,6-mannosyltransferase activity, mannosyltransferase activity		
YPL051W	ARL3	GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor [Source:SGD;Acc:S000005972]	Golgi to plasma membrane protein transport, intracellular protein transport, protein transport, small GTPase mediated signal transduction, transport	Golgi apparatus, intracellular, nuclear outer membrane-endoplasmic reticulum membrane network, soluble fraction	GTP binding, GTPase activity, nucleotide binding		
YPL052W	OAZ1	Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to regulate ubiquitin-independent degradation; ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine-regulated [Source:SGD;Acc:S000005973]	protein catabolic process	cell	enzyme inhibitor activity		
YPL053C	KTR6	Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000005974]	fungal-type cell wall organization, protein N-linked glycosylation, protein glycosylation	integral to membrane, membrane, membrane fraction	glycolipid 2-alpha-mannosyltransferase activity, mannosylphosphate transferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YPL054W	LEE1	Zinc-finger protein of unknown function [Source:SGD;Acc:S000005975]	biological_process	cellular_component	metal ion binding, molecular_function, nucleic acid binding, zinc ion binding		
YPL055C	LGE1	Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division [Source:SGD;Acc:S000005976]	chromatin modification, histone methylation, histone ubiquitination, premeiotic DNA replication, protein monoubiquitination, regulation of cell size	nucleus	molecular_function		
YPL056C	LCL1	Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan [Source:SGD;Acc:S000005977]	biological_process	anchored to membrane, cellular_component, membrane, plasma membrane	molecular_function		
YPL057C	SUR1	Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p [Source:SGD;Acc:S000005978]	glycosphingolipid biosynthetic process, mannosyl-inositol phosphorylceramide metabolic process, sphingolipid biosynthetic process	integral to membrane, intracellular, membrane	mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YPL058C	PDR12	Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity [Source:SGD;Acc:S000005979]	organic acid transport, propionate metabolic process, transport	integral to membrane, membrane, plasma membrane	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding, organic acid transmembrane transporter activity, xenobiotic-transporting ATPase activity		
YPL059W	GRX5	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p [Source:SGD;Acc:S000005980]	cell redox homeostasis, cellular response to oxidative stress, iron-sulfur cluster assembly, response to osmotic stress	mitochondrial matrix, mitochondrion	2 iron, 2 sulfur cluster binding, disulfide oxidoreductase activity, electron carrier activity, iron-sulfur cluster binding, metal ion binding, protein disulfide oxidoreductase activity		
YPL060W	MFM1	Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p [Source:SGD;Acc:S000005981]	RNA splicing, ion transport, mRNA processing, mitochondrial magnesium ion transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	magnesium ion transmembrane transporter activity		
YPL061W	ALD6	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress [Source:SGD;Acc:S000005982]	NADPH regeneration, acetate biosynthetic process, metabolic process, oxidation-reduction process, response to salt stress	cytoplasm, cytosol, mitochondrion	aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity, oxidoreductase activity		
YPL062W	YPL062W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation [Source:SGD;Acc:S000005983]					
YPL063W	TIM50	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel [Source:SGD;Acc:S000005984]	protein import into mitochondrial matrix, protein transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrial inner membrane presequence translocase complex, mitochondrion	mitochondrion targeting sequence binding, protein binding, protein channel activity		
YPL064C	CWC27	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p [Source:SGD;Acc:S000005985]	RNA splicing, biological_process, mRNA processing, protein folding	U2-type spliceosomal complex, cytoplasm, nucleus, spliceosomal complex	isomerase activity, molecular_function, peptidyl-prolyl cis-trans isomerase activity		
YPL065W	VPS28	Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p [Source:SGD;Acc:S000005986]	protein targeting to membrane, protein targeting to vacuole, protein transport, transport, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ESCRT I complex, cytoplasm, endosome, late endosome membrane, membrane			
YPL066W	YPL066W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source [Source:SGD;Acc:S000005987]	biological_process	cellular bud neck, cytoplasm	molecular_function		
YPL067C	YPL067C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene [Source:SGD;Acc:S000005988]	biological_process	cytoplasm	molecular_function		
YPL068C	YPL068C	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000005989]	biological_process	nucleus	molecular_function		
YPL069C	BTS1	Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic [Source:SGD;Acc:S000005990]	carotenoid biosynthetic process, isoprenoid biosynthetic process, protein transport, terpenoid biosynthetic process, transport	cytoplasm, mitochondrion	dimethylallyltranstransferase activity, farnesyltranstransferase activity, geranyltranstransferase activity, metal ion binding, transferase activity		
YPL070W	MUK1	Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation [Source:SGD;Acc:S000005991]	biological_process	cytoplasm	GTPase activator activity, molecular_function		
YPL071C	YPL071C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000005992]	biological_process	cytoplasm, nucleus	molecular_function		
YPL072W	UBP16	Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria [Source:SGD;Acc:S000005993]	protein deubiquitination, ubiquitin-dependent protein catabolic process	cytoplasm, mitochondrial outer membrane	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity, ubiquitin-specific protease activity		
YPL073C	YPL073C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments [Source:SGD;Acc:S000005994]					
YPL074W	YTA6	Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells [Source:SGD;Acc:S000005995]	biological_process	cell cortex	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding		
YPL075W	GCR1	Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p [Source:SGD;Acc:S000005996]	positive regulation of glycolysis, positive regulation of transcription from RNA polymerase II promoter	nuclear envelope, nucleus	DNA binding		
YPL076W	GPI2	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein [Source:SGD;Acc:S000005997]	GPI anchor biosynthetic process	endoplasmic reticulum, glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, integral to membrane, membrane	UDP-glycosyltransferase activity, phosphatidylinositol N-acetylglucosaminyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YPL077C	YPL077C	Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene [Source:SGD;Acc:S000005998]	biological_process	cellular_component	molecular_function		
YPL078C	ATP4	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [Source:SGD;Acc:S000005999]	ATP synthesis coupled proton transport, ion transport, proton transport, transport	membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase complex, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrial proton-transporting ATP synthase, stator stalk, mitochondrion, proton-transporting ATP synthase complex, coupling factor F(o)	ATPase activity, hydrogen ion transmembrane transporter activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism		
YPL079W	RPL21B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein [Source:SGD;Acc:S000006000]	translation	cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YPL080C	YPL080C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006001]					
YPL081W	RPS9A	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins [Source:SGD;Acc:S000006002]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis, translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome	RNA binding, rRNA binding, structural constituent of ribosome		
YPL082C	MOT1	Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity [Source:SGD;Acc:S000006003]	rRNA processing, regulation of RNA polymerase II transcriptional preinitiation complex assembly, regulation of transcription from RNA polymerase II promoter, transcription of nuclear rRNA large RNA polymerase I transcript	mitochondrion, nuclear chromosome, nucleus	ATP binding, ATPase activity, DNA binding, TBP-class protein binding, binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, rDNA binding		
YPL083C	SEN54	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p [Source:SGD;Acc:S000006004]	tRNA processing, tRNA-type intron splice site recognition and cleavage	endomembrane system, membrane, mitochondrial outer membrane, mitochondrion, nucleus, tRNA-intron endonuclease complex	tRNA-intron endonuclease activity		
YPL084W	BRO1	Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes [Source:SGD;Acc:S000006005]	protein deubiquitination, protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, protein transport, response to nutrient, transport, ubiquitin-dependent protein catabolic process, vacuolar transport	cytoplasm, endosome, membrane fraction	ubiquitin-specific protease activity		
YPL085W	SEC16	COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p [Source:SGD;Acc:S000006006]	COPII vesicle coating, autophagy, protein transport, transport, vesicle-mediated transport	ER to Golgi transport vesicle membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane	protein anchor		
YPL086C	ELP3	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin [Source:SGD;Acc:S000006007]	chromatin modification, metabolic process, protein transport, regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification, transport	Elongator holoenzyme complex, cytoplasm, nucleus	N-acetyltransferase activity, acyltransferase activity, catalytic activity, histone acetyltransferase activity, iron-sulfur cluster binding, metal ion binding, transferase activity		
YPL087W	YDC1	Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity [Source:SGD;Acc:S000006008]	ceramide biosynthetic process, ceramide catabolic process, ceramide metabolic process	Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dihydroceramidase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides		
YPL088W	YPL088W	Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance [Source:SGD;Acc:S000006009]	cellular aldehyde metabolic process, oxidation-reduction process	cellular_component	aryl-alcohol dehydrogenase activity, oxidoreductase activity		
YPL089C	RLM1	MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p [Source:SGD;Acc:S000006010]	fungal-type cell wall organization, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to acid, signal transduction	nucleus	DNA bending activity, DNA binding, mitogen-activated protein kinase binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YPL090C	RPS6A	Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein [Source:SGD;Acc:S000006011]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis, translation	90S preribosome, cytoplasm, cytosolic small ribosomal subunit, intracellular, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small-subunit processome	structural constituent of ribosome		
YPL091W	GLR1	Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia [Source:SGD;Acc:S000006012]	cell redox homeostasis, cellular response to oxidative stress, glutathione metabolic process, oxidation-reduction process, protein glutathionylation	cytoplasm, mitochondrion, nucleus	NADP binding, flavin adenine dinucleotide binding, glutathione-disulfide reductase activity, oxidoreductase activity		
YPL092W	SSU1	Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein [Source:SGD;Acc:S000006013]	sulfite transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	sulfite transmembrane transporter activity		
YPL093W	NOG1	Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins [Source:SGD;Acc:S000006014]	rRNA processing, ribosomal large subunit biogenesis, ribosomal subunit export from nucleus, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor	GTP binding, nucleotide binding		
YPL094C	SEC62	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER [Source:SGD;Acc:S000006015]	posttranslational protein targeting to membrane, translocation, protein transport, transmembrane transport, transport	Sec62/Sec63 complex, endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane	protein transporter activity		
YPL095C	EEB1	Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification [Source:SGD;Acc:S000006016]	medium-chain fatty acid biosynthetic process, medium-chain fatty acid catabolic process	cellular_component	acyltransferase activity, alcohol O-acetyltransferase activity, alcohol O-octanoyltransferase activity, carboxylesterase activity, hydrolase activity, short-chain carboxylesterase activity, transferase activity		
YPL096C-A	ERI1	Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein [Source:SGD;Acc:S000028423]	GPI anchor biosynthetic process, Ras protein signal transduction	endoplasmic reticulum, endoplasmic reticulum membrane, glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, integral to membrane, membrane	GTPase inhibitor activity		
YPL096W	PNG1	Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p [Source:SGD;Acc:S000006017]	misfolded or incompletely synthesized protein catabolic process, nucleotide-excision repair, protein deglycosylation	cytoplasm, cytosol, mitochondrion, nucleus	damaged DNA binding, hydrolase activity, metal ion binding, peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity		
YPL097W	MSY1	Mitochondrial tyrosyl-tRNA synthetase [Source:SGD;Acc:S000006018]	mitochondrial tyrosyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation, tyrosyl-tRNA aminoacylation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, tyrosine-tRNA ligase activity		
YPL098C	MGR2	Protein required for growth of cells lacking the mitochondrial genome [Source:SGD;Acc:S000006019]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YPL099C	AIM43	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000006020]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YPL100W	ATG21	Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein [Source:SGD;Acc:S000006021]	CVT pathway, autophagy, macroautophagy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein lipidation, protein localization to pre-autophagosomal structure, protein transport, transport, vesicle organization	cytoplasm, cytosol, endosome, fungal-type vacuole membrane, vacuole	phosphatidylinositol binding, protein binding		
YPL101W	ELP4	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity [Source:SGD;Acc:S000006022]	regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification	Elongator holoenzyme complex, cytoplasm, nucleus	molecular_function		
YPL102C	YPL102C	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4 [Source:SGD;Acc:S000006023]					
YPL103C	FMP30	Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D [Source:SGD;Acc:S000006024]	N-acylethanolamine metabolic process, N-acylphosphatidylethanolamine metabolic process, lipid metabolic process, phospholipid catabolic process	integral to membrane, integral to mitochondrial inner membrane, membrane, mitochondrial membrane, mitochondrion	NAPE-specific phospholipase D activity, hydrolase activity, metal ion binding		
YPL104W	MSD1	Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene [Source:SGD;Acc:S000006025]	aspartyl-tRNA aminoacylation, mitochondrial aspartyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, aspartate-tRNA ligase activity, ligase activity, nucleic acid binding, nucleotide binding		
YPL105C	SYH1	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000006026]	biological_process	cytoplasm, mitochondrion, ribosome	molecular_function, protein binding		
YPL106C	SSE1	ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm [Source:SGD;Acc:S000006027]	protein folding, protein refolding, response to stress	cytoplasm	ATP binding, adenyl-nucleotide exchange factor activity, calmodulin binding, nucleotide binding, peptide binding		
YPL107W	YPL107W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene [Source:SGD;Acc:S000006028]	biological_process	mitochondrion	molecular_function		
YPL108W	YPL108W	Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000006029]	biological_process	cytoplasm	molecular_function		
YPL109C	YPL109C	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000006030]	biological_process	mitochondrion	molecular_function		
YPL110C	GDE1	Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes [Source:SGD;Acc:S000006031]	glycerol metabolic process, glycerophospholipid catabolic process, intracellular signal transduction, lipid metabolic process	cytoplasm, ribosome	glycerophosphocholine phosphodiesterase activity, glycerophosphodiester phosphodiesterase activity, hydrolase activity, phospholipase C activity, phosphoric diester hydrolase activity, protein binding		
YPL111W	CAR1	Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance [Source:SGD;Acc:S000006032]	arginine catabolic process to ornithine, arginine metabolic process, regulation of ornithine metabolic process	cytoplasm, cytosol, mating projection tip, nucleus	arginase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines, manganese ion binding, metal ion binding, ornithine carbamoyltransferase inhibitor activity, zinc ion binding		
YPL112C	PEX25	Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p [Source:SGD;Acc:S000006033]	peroxisome organization, protein import into peroxisome matrix	integral to membrane, membrane, peroxisomal membrane, peroxisome	molecular_function		
YPL113C	YPL113C	Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene [Source:SGD;Acc:S000006034]	metabolic process, oxidation-reduction process	cellular_component	binding, catalytic activity, cofactor binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		
YPL114W	YPL114W	Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index [Source:SGD;Acc:S000006035]					
YPL115C	BEM3	Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly [Source:SGD;Acc:S000006036]	budding cell apical bud growth, budding cell isotropic bud growth, cell communication, establishment of cell polarity, invasive growth in response to glucose limitation, negative regulation of Rho protein signal transduction, pseudohyphal growth, signal transduction	cell cortex, cellular bud tip, cytoplasm, incipient cellular bud site, intracellular, mating projection tip	GTPase activator activity, Rho GTPase activator activity, phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding		
YPL116W	HOS3	Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats [Source:SGD;Acc:S000006037]	chromatin modification, histone deacetylation, regulation of transcription involved in G1/S phase of mitotic cell cycle	cellular bud neck, cytoplasm, nucleus	histone deacetylase activity, hydrolase activity		
YPL117C	IDI1	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability [Source:SGD;Acc:S000006038]	carotenoid biosynthetic process, cholesterol biosynthetic process, farnesyl diphosphate biosynthetic process, isoprenoid biosynthetic process, lipid biosynthetic process, steroid biosynthetic process, sterol biosynthetic process	cytoplasm, nucleus	hydrolase activity, isomerase activity, isopentenyl-diphosphate delta-isomerase activity, metal ion binding		
YPL118W	MRP51	Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences [Source:SGD;Acc:S000006039]	mitochondrial translation, mitochondrial translational initiation	mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YPL119C	DBP1	Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs [Source:SGD;Acc:S000006040]	translation, translational initiation	cytoplasm	ATP binding, ATP-dependent helicase activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, translation initiation factor activity		
YPL119C-A	YPL119C-A	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028859]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YPL120W	VPS30	Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1 [Source:SGD;Acc:S000006041]	CVT pathway, ER-associated protein catabolic process, autophagy, late endosome to vacuole transport, macroautophagy, peroxisome degradation, phosphatidylinositol biosynthetic process, piecemeal microautophagy of nucleus, protein transport, retrograde transport, endosome to Golgi, transport	endosome, endosome membrane, membrane, membrane fraction, peripheral to membrane of membrane fraction, phosphatidylinositol 3-kinase complex I, phosphatidylinositol 3-kinase complex II, vacuolar membrane, vacuole	1-phosphatidylinositol-3-kinase activity		
YPL121C	MEI5	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p [Source:SGD;Acc:S000006042]	DNA repair, meiosis, meiotic DNA recombinase assembly, reciprocal meiotic recombination, response to DNA damage stimulus, sporulation resulting in formation of a cellular spore	condensed nuclear chromosome, nucleus	molecular_function		
YPL122C	TFB2	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH [Source:SGD;Acc:S000006043]	DNA repair, nucleotide-excision repair, phosphorylation of RNA polymerase II C-terminal domain, regulation of transcription, DNA-dependent, response to DNA damage stimulus	core TFIIH complex, holo TFIIH complex, nucleotide-excision repair factor 3 complex, nucleus	double-stranded DNA binding		
YPL123C	RNY1	Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity [Source:SGD;Acc:S000006044]	RNA catabolic process, apoptosis, cell morphogenesis	cytoplasm, cytosol, extracellular region, vacuolar lumen, vacuole	RNA binding, endonuclease activity, endoribonuclease activity, hydrolase activity, nuclease activity, ribonuclease T2 activity		
YPL124W	SPC29	Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication [Source:SGD;Acc:S000006045]	microtubule nucleation, spindle pole body duplication in nuclear envelope	central plaque of spindle pole body	structural constituent of cytoskeleton		
YPL125W	KAP120	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p [Source:SGD;Acc:S000006046]	intracellular protein transport, protein import into nucleus, protein transport, transcription factor import into nucleus, transport	cytoplasm, nuclear pore, nucleus	binding, protein transporter activity, structural constituent of nuclear pore		
YPL126W	NAN1	U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA [Source:SGD;Acc:S000006047]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of transcription from RNA polymerase I promoter, rRNA processing, ribosome biogenesis	90S preribosome, RENT complex, nucleolus, nucleus, rDNA heterochromatin, ribonucleoprotein complex, small-subunit processome, t-UTP complex	protein binding, snoRNA binding		
YPL127C	HHO1	Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation [Source:SGD;Acc:S000006048]	negative regulation of DNA recombination, negative regulation of chromatin silencing, nucleosome assembly, regulation of transcription, DNA-dependent	chromosome, nuclear nucleosome, nucleosome, nucleus	DNA binding		
YPL128C	TBF1	Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression [Source:SGD;Acc:S000006049]	cell cycle, loss of chromatin silencing, snoRNA transcription from an RNA polymerase II promoter, telomere maintenance via telomerase	chromosome, telomeric region, nuclear chromosome, nuclear chromosome, telomeric region, nucleus	DNA binding, chromatin insulator sequence binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, telomeric DNA binding		
YPL129W	TAF14	Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain [Source:SGD;Acc:S000006050]	RNA polymerase II transcriptional preinitiation complex assembly, chromatin remodeling, histone acetylation, nucleosome mobilization, regulation of transcription, DNA-dependent	Ino80 complex, NuA3 histone acetyltransferase complex, RSC complex, SWI/SNF complex, mediator complex, nucleus, transcription factor TFIID complex, transcription factor TFIIF complex	histone acetyltransferase activity		
YPL130W	SPO19	Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation [Source:SGD;Acc:S000006051]	meiosis, spore membrane bending pathway, sporulation resulting in formation of a cellular spore	anchored to membrane, cell wall, extracellular region, fungal-type cell wall, membrane, prospore membrane	molecular_function		
YPL131W	RPL5	Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly [Source:SGD;Acc:S000006052]	ribosomal large subunit assembly, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	5S rRNA binding, RNA binding, rRNA binding, structural constituent of ribosome		
YPL132W	COX11	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p [Source:SGD;Acc:S000006053]	aerobic respiration, protein complex assembly	integral to membrane, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial ribosome, mitochondrion	copper ion binding		
YPL133C	RDS2	Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole [Source:SGD;Acc:S000006054]	cellular cell wall organization, positive regulation of gluconeogenesis, regulation of transcription, DNA-dependent, response to xenobiotic stimulus, signal transduction	cytoplasm, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, signal transducer activity, zinc ion binding		
YPL134C	ODC1	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation [Source:SGD;Acc:S000006055]	mitochondrial transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, dicarboxylic acid transmembrane transporter activity, transporter activity		
YPL135C-A	YPL135C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028720]					
YPL135W	ISU1	Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable [Source:SGD;Acc:S000006056]	cellular iron ion homeostasis, iron-sulfur cluster assembly, tRNA wobble uridine modification	mitochondrial matrix, mitochondrion	2 iron, 2 sulfur cluster binding, ferrous iron binding, iron ion binding, iron-sulfur cluster binding, metal ion binding		
YPL136W	YPL136W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C [Source:SGD;Acc:S000006057]					
YPL137C	GIP3	Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000006058]	chromosome segregation, regulation of phosphoprotein phosphatase activity	cytoplasm, endoplasmic reticulum, mitochondrion, ribosome	protein phosphatase 1 binding, protein phosphatase type 1 regulator activity		
YPL138C	SPP1	Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein [Source:SGD;Acc:S000006059]	chromatin silencing at telomere, histone H3-K4 methylation, regulation of transcription, DNA-dependent	Set1C/COMPASS complex, nucleus	chromatin binding, histone methyltransferase activity (H3-K4 specific), metal ion binding, methylated histone residue binding, protein binding, zinc ion binding		
YPL139C	UME1	Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p [Source:SGD;Acc:S000006060]	chromatin modification, histone deacetylation, meiosis, negative regulation of chromatin silencing at telomere, negative regulation of transcription from RNA polymerase I promoter, regulation of meiosis	Rpd3L complex, Rpd3L-Expanded complex, Rpd3S complex, cytoplasm, nucleus	histone deacetylase activity, protein binding, transcription corepressor activity		
YPL140C	MKK2	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p [Source:SGD;Acc:S000006061]	peroxisome degradation, protein phosphorylation, signal transduction	intracellular	ATP binding, MAP kinase kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity		
YPL141C	FRK1	Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3 [Source:SGD;Acc:S000006062]	biological_process, protein phosphorylation	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPL142C	YPL142C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit [Source:SGD;Acc:S000006063]					
YPL143W	RPL33A	N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable [Source:SGD;Acc:S000006064]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YPL144W	POC4	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions [Source:SGD;Acc:S000006065]	chaperone-mediated protein complex assembly, proteasome assembly	cytoplasm, intracellular	molecular_function		
YPL145C	KES1	Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex [Source:SGD;Acc:S000006066]	endocytosis, exocytosis, lipid biosynthetic process, maintenance of cell polarity, post-Golgi vesicle-mediated transport, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, sterol transport	Golgi membrane, cytoplasm, extrinsic to membrane	cholesterol binding, lipid binding, oxysterol binding, phosphatidic acid binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylinositol-4-phosphate binding, sterol transporter activity		
YPL146C	NOP53	Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired [Source:SGD;Acc:S000006067]	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal large subunit export from nucleus, ribosome biogenesis	nucleolus, nucleoplasm, nucleus	RNA binding, rRNA binding		
YPL147W	PXA1	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins [Source:SGD;Acc:S000006068]	fatty acid transport, transmembrane transport, transport	integral to membrane, integral to peroxisomal membrane, membrane, peroxisomal membrane, peroxisome	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding		
YPL148C	PPT2	Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation [Source:SGD;Acc:S000006069]	fatty acid biosynthetic process, lipid biosynthetic process, macromolecule biosynthetic process, protein-cofactor linkage	mitochondrion	holo-[acyl-carrier-protein] synthase activity, magnesium ion binding, transferase activity		
YPL149W	ATG5	Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation [Source:SGD;Acc:S000006070]	C-terminal protein lipidation, CVT pathway, autophagy, macroautophagy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein transport, transport	Atg12-Atg5-Atg16 complex, autophagic vacuole, cytoplasm, cytosol, membrane, pre-autophagosomal structure, pre-autophagosomal structure membrane	Atg8 ligase activity, hydrolase activity		
YPL150W	YPL150W	Putative protein kinase of unknown cellular role [Source:SGD;Acc:S000006071]	biological_process, protein phosphorylation	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPL151C	PRP46	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs [Source:SGD;Acc:S000006072]	RNA splicing, cell cycle, mRNA processing, nuclear mRNA splicing, via spliceosome	Prp19 complex, cytoplasm, nucleus, spliceosomal complex	molecular_function, protein binding		
YPL152W	RRD2	Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex [Source:SGD;Acc:S000006073]	mitotic spindle organization in nucleus, response to osmotic stress	cell fraction, cytoplasm, cytosol, protein phosphatase type 2A complex	isomerase activity, peptidyl-prolyl cis-trans isomerase activity, phosphatase activator activity, protein phosphatase type 2A regulator activity		
YPL152W-A	YPL152W-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028721]	biological_process	cellular_component	molecular_function		
YPL153C	RAD53	Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication [Source:SGD;Acc:S000006074]	DNA damage checkpoint, DNA repair, DNA-dependent DNA replication initiation, cell cycle, deoxyribonucleoside triphosphate biosynthetic process, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, protein localization, protein phosphorylation, response to DNA damage stimulus	nucleus	ATP binding, DNA replication origin binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity		
YPL154C	PEP4	Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates [Source:SGD;Acc:S000006075]	cellular response to starvation, microautophagy, proteolysis, proteolysis involved in cellular protein catabolic process, sporulation resulting in formation of a cellular spore, vacuolar protein catabolic process	fungal-type vacuole, fungal-type vacuole lumen, mitochondrion, vacuole	aspartic-type endopeptidase activity, hydrolase activity, peptidase activity		
YPL155C	KIP2	Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle [Source:SGD;Acc:S000006076]	cell cycle, cell division, microtubule-based movement, mitosis, mitotic anaphase B, negative regulation of microtubule depolymerization, nuclear migration along microtubule	cytoplasm, cytoplasmic microtubule, cytoskeleton, kinesin complex, microtubule, mitochondrion	ATP binding, microtubule motor activity, motor activity, nucleotide binding		
YPL156C	PRM4	Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift [Source:SGD;Acc:S000006077]	biological_process, cell redox homeostasis	integral to membrane, membrane	electron carrier activity, molecular_function, protein disulfide oxidoreductase activity		
YPL157W	TGS1	Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology [Source:SGD;Acc:S000006078]	RNA capping, RNA methylation, nucleolus organization, replicative cell aging, ribosome biogenesis, snRNA capping, telomere maintenance via telomerase	nucleolus, nucleus	RNA methyltransferase activity, methyltransferase activity, transferase activity		
YPL158C	AIM44	Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000006079]	biological_process	cellular bud neck	molecular_function		
YPL159C	PET20	Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome [Source:SGD;Acc:S000006080]	aerobic respiration	mitochondrion	molecular_function		
YPL160W	CDC60	Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA [Source:SGD;Acc:S000006081]	leucyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm	ATP binding, aminoacyl-tRNA ligase activity, leucine-tRNA ligase activity, ligase activity, nucleotide binding		
YPL161C	BEM4	Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length [Source:SGD;Acc:S000006082]	Rho protein signal transduction, actin cytoskeleton organization, establishment of cell polarity, response to pheromone	cytoplasm, nucleus	GTPase activator activity, molecular_function		
YPL162C	YPL162C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology [Source:SGD;Acc:S000006083]	biological_process	fungal-type vacuole membrane, integral to membrane, membrane, vacuolar membrane, vacuole	molecular_function		
YPL163C	SVS1	Cell wall and vacuolar protein, required for wild-type resistance to vanadate [Source:SGD;Acc:S000006084]	response to chemical stimulus	fungal-type cell wall, fungal-type vacuole	molecular_function		
YPL164C	MLH3	Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability [Source:SGD;Acc:S000006085]	DNA repair, mismatch repair, reciprocal meiotic recombination, response to DNA damage stimulus	MutLbeta complex, nucleus	ATP binding, mismatched DNA binding, molecular_function		
YPL165C	SET6	SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability [Source:SGD;Acc:S000006086]	biological_process	cellular_component	molecular_function, protein binding, transferase activity		
YPL166W	ATG29	Autophagy-specific protein that is required for recruitment of other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved [Source:SGD;Acc:S000006087]	autophagy, macroautophagy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein transport, transport	cytoplasm, pre-autophagosomal structure	molecular_function		
YPL167C	REV3	Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair [Source:SGD;Acc:S000006088]	DNA repair, DNA replication, error-free translesion synthesis, error-prone translesion synthesis, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, response to DNA damage stimulus	mitochondrion, nuclear chromatin, nucleus, zeta DNA polymerase complex	DNA binding, DNA-directed DNA polymerase activity, metal ion binding, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, transferase activity		
YPL168W	YPL168W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated [Source:SGD;Acc:S000006089]	biological_process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YPL169C	MEX67	Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP [Source:SGD;Acc:S000006090]	mRNA export from nucleus, mRNA transport, ribosomal large subunit export from nucleus, transport	cytoplasm, nuclear RNA export factor complex, nuclear pore, nucleus	RNA binding, protein binding, structural constituent of nuclear pore		
YPL170W	DAP1	Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis [Source:SGD;Acc:S000006091]	regulation of ergosterol biosynthetic process	endosome, membrane	heme binding		
YPL171C	OYE3	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death [Source:SGD;Acc:S000006092]	apoptosis, metabolic process, oxidation-reduction process	cellular_component	FMN binding, NADPH dehydrogenase activity, catalytic activity, oxidoreductase activity		
YPL172C	COX10	Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders [Source:SGD;Acc:S000006093]	heme O biosynthetic process, heme a biosynthetic process, heme biosynthetic process	integral to membrane, membrane, mitochondrial membrane, mitochondrion	prenyltransferase activity, protoheme IX farnesyltransferase activity, transferase activity		
YPL173W	MRPL40	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000006094]	mitochondrial translation, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YPL174C	NIP100	Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) [Source:SGD;Acc:S000006095]	establishment of mitotic spindle orientation	astral microtubule, cell cortex, cytoplasm, cytoskeleton, dynactin complex, dynein complex, microtubule, spindle pole, spindle pole body	microtubule binding, motor activity		
YPL175W	SPT14	UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins [Source:SGD;Acc:S000006096]	GPI anchor biosynthetic process, biosynthetic process	endoplasmic reticulum, endoplasmic reticulum membrane, glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, integral to membrane, membrane	UDP-glycosyltransferase activity, phosphatidylinositol N-acetylglucosaminyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YPL176C	TRE1	Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors [Source:SGD;Acc:S000006097]	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	fungal-type vacuole, integral to membrane, membrane, plasma membrane	molecular_function		
YPL177C	CUP9	Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription [Source:SGD;Acc:S000006098]	cellular copper ion homeostasis, regulation of transcription, DNA-dependent, transcription initiation from RNA polymerase II promoter	nucleus	DNA binding, protein binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YPL178W	CBC2	Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif [Source:SGD;Acc:S000006099]	RNA splicing, mRNA processing, mRNA transport, nuclear mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, transport	commitment complex, cytoplasm, nuclear cap binding complex, nucleus, perinuclear region of cytoplasm	RNA binding, RNA cap binding, nucleic acid binding, nucleotide binding		
YPL179W	PPQ1	Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors [Source:SGD;Acc:S000006100]	protein dephosphorylation, regulation of translation	cytoplasm	cofactor binding, hydrolase activity, magnesium-dependent protein serine/threonine phosphatase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity		
YPL180W	TCO89	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin [Source:SGD;Acc:S000006101]	TOR signaling cascade, fungal-type cell wall organization, glycerol metabolic process, regulation of cell growth, response to salt stress	TORC1 complex, extrinsic to internal side of plasma membrane, extrinsic to vacuolar membrane, fungal-type vacuole membrane, membrane, plasma membrane, vacuolar membrane, vacuole	molecular_function		
YPL181W	CTI6	Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain [Source:SGD;Acc:S000006102]	chromatin modification, histone deacetylation, regulation of DNA-dependent DNA replication initiation	Rpd3L complex, Rpd3L-Expanded complex, nucleus	histone deacetylase activity, metal ion binding, methylated histone residue binding, protein binding, transcription factor binding, zinc ion binding		
YPL182C	YPL182C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W [Source:SGD;Acc:S000006103]					
YPL183C	RTT10	Cytoplasmic protein with a role in regulation of Ty1 transposition [Source:SGD;Acc:S000006104]	biological_process	cytoplasm	molecular_function, protein binding		
YPL183W-A	RTC6	Protein involved translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein encoded in the nucleus [Source:SGD;Acc:S000007224]	mitochondrial translation, ribosome biogenesis, translation	intracellular, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YPL184C	MRN1	RNA-binding protein proposed to be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES) [Source:SGD;Acc:S000006105]	biological_process	cytoplasm	RNA binding, molecular_function, nucleic acid binding, nucleotide binding		
YPL185W	YPL185W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C [Source:SGD;Acc:S000006106]					
YPL186C	UIP4	Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope [Source:SGD;Acc:S000006107]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion, nuclear envelope, nucleus	molecular_function		
YPL187W	MF(ALPHA)1	Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor [Source:SGD;Acc:S000006108]	mating, pheromone-dependent signal transduction involved in conjugation with cellular fusion, sexual reproduction	extracellular region	mating pheromone activity, pheromone activity		
YPL188W	POS5	Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress [Source:SGD;Acc:S000006109]	NADP biosynthetic process, cellular response to oxidative stress, metabolic process	mitochondrial matrix, mitochondrion	ATP binding, NAD+ kinase activity, NADH kinase activity, kinase activity, nucleotide binding, transferase activity		
YPL189C-A	COA2	Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p [Source:SGD;Acc:S000028527]	mitochondrial respiratory chain complex IV assembly	membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion	molecular_function		
YPL189W	GUP2	Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog [Source:SGD;Acc:S000006110]	glycerol transport, transport	integral to membrane, membrane	O-acyltransferase activity, symporter activity		
YPL190C	NAB3	Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p [Source:SGD;Acc:S000006111]	regulation of transcription from RNA polymerase II promoter, termination of RNA polymerase II transcription, exosome-dependent, translation	Nrd1 complex, nucleoplasm, nucleus	ATP binding, RNA binding, aminoacyl-tRNA ligase activity, nucleic acid binding, nucleotide binding, poly(A) RNA binding, transcription regulatory region RNA binding		
YPL191C	YPL191C	Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000006112]	biological_process	cytoplasm	molecular_function		
YPL192C	PRM3	Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body [Source:SGD;Acc:S000006113]	karyogamy involved in conjugation with cellular fusion, nuclear membrane fusion involved in karyogamy	cytoplasm, cytoskeleton, extrinsic to nuclear outer membrane, integral to membrane, membrane, nuclear envelope, nuclear outer membrane, nucleus, spindle pole body	molecular_function		
YPL193W	RSA1	Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly [Source:SGD;Acc:S000006114]	ribosomal large subunit assembly, ribosome biogenesis	nucleoplasm, nucleus	molecular_function		
YPL194W	DDC1	DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate [Source:SGD;Acc:S000006115]	DNA repair, G2/M transition checkpoint, cell cycle checkpoint, intra-S DNA damage checkpoint, meiosis, mitotic cell cycle G1/S transition checkpoint, recombinational repair, response to DNA damage stimulus	checkpoint clamp complex, condensed nuclear chromosome, cytoplasm, nucleus	DNA binding, molecular_function		
YPL195W	APL5	Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function [Source:SGD;Acc:S000006116]	Golgi to vacuole transport, intracellular protein transport, protein transport, transport, vesicle-mediated transport	AP-3 adaptor complex, Golgi apparatus, clathrin coated vesicle membrane, cytoplasmic vesicle, membrane, membrane coat	binding, protein binding, protein transporter activity		
YPL196W	OXR1	Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes [Source:SGD;Acc:S000006117]	cellular response to oxidative stress	mitochondrion	molecular_function		
YPL197C	YPL197C	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B [Source:SGD;Acc:S000006118]					
YPL198W	RPL7B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2) [Source:SGD;Acc:S000006119]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, large ribosomal subunit, nucleolus, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YPL199C	YPL199C	Putative protein of unknown function, predicted to be palmitoylated [Source:SGD;Acc:S000006120]	biological_process	cytoplasm	molecular_function		
YPL200W	CSM4	Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements [Source:SGD;Acc:S000006121]	chromosome segregation, meiosis, meiotic chromosome segregation, meiotic telomere clustering, regulation of reciprocal meiotic recombination, sporulation resulting in formation of a cellular spore, synapsis	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, nuclear chromosome, telomeric region, nuclear membrane, nucleus	molecular_function		
YPL201C	YIG1	Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol [Source:SGD;Acc:S000006122]	glycerol biosynthetic process	cytoplasm, cytosol, nucleus	molecular_function		
YPL202C	AFT2	Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p [Source:SGD;Acc:S000006123]	cellular iron ion homeostasis, cellular response to oxidative stress, transcription initiation from RNA polymerase II promoter	mitochondrion, nucleus	sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YPL203W	TPK2	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase [Source:SGD;Acc:S000006124]	Ras protein signal transduction, invasive growth in response to glucose limitation, protein phosphorylation	cAMP-dependent protein kinase complex, nucleus	ATP binding, cAMP-dependent protein kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPL204W	HRR25	Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) [Source:SGD;Acc:S000006125]	DNA repair, ER to Golgi vesicle-mediated transport, attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation, mitosis, protein phosphorylation, response to DNA damage stimulus, ribosomal small subunit biogenesis, tRNA wobble uridine modification	cellular bud neck, cellular bud tip, chromosome, centromeric region, cytoplasm, monopolin complex, nucleolus, nucleoplasm, nucleus, plasma membrane, spindle pole body	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPL205C	YPL205C	Hypothetical protein; deletion of locus affects telomere length [Source:SGD;Acc:S000006126]					
YPL206C	PGC1	Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs [Source:SGD;Acc:S000006127]	glycerol metabolic process, glycerophospholipid catabolic process, lipid metabolic process, phosphatidylglycerol catabolic process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, lipid particle, membrane, mitochondrion	glycerophosphodiester phosphodiesterase activity, hydrolase activity, phosphatidylglycerol phospholipase C activity, phosphoric diester hydrolase activity		
YPL207W	TYW1	Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions [Source:SGD;Acc:S000006128]	tRNA processing, wybutosine biosynthetic process	endoplasmic reticulum	4 iron, 4 sulfur cluster binding, FMN binding, catalytic activity, iron-sulfur cluster binding, metal ion binding, molecular_function, nucleotide binding, oxidoreductase activity		
YPL208W	RKM1	SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B) [Source:SGD;Acc:S000006129]	peptidyl-lysine dimethylation	cytoplasm, nucleus	methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity		
YPL209C	IPL1	Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase [Source:SGD;Acc:S000006130]	attachment of spindle microtubules to kinetochore, cell cycle, chromosome segregation, meiotic sister chromatid segregation, mitotic cell cycle G2/M transition decatenation checkpoint, mitotic spindle disassembly, protein phosphorylation, regulation of cytokinesis, spindle checkpoint	chromosome passenger complex, chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, cytoplasm, cytoskeleton, kinetochore, kinetochore microtubule, nucleus, spindle, spindle microtubule, spindle midzone	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPL210C	SRP72	Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane [Source:SGD;Acc:S000006131]	SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, protein targeting to ER	cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting	7S RNA binding, binding, protein binding, signal sequence binding		
YPL211W	NIP7	Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p [Source:SGD;Acc:S000006132]	rRNA processing, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome assembly, ribosome biogenesis	cytoplasm, cytosolic large ribosomal subunit, nucleolus, nucleus, preribosome, large subunit precursor	RNA binding, molecular_function		
YPL212C	PUS1	tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA [Source:SGD;Acc:S000006133]	RNA modification, pseudouridine synthesis, snRNA pseudouridine synthesis, tRNA processing, tRNA pseudouridine synthesis	nucleus	RNA binding, isomerase activity, pseudouridine synthase activity		
YPL213W	LEA1	Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein [Source:SGD;Acc:S000006134]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U2 snRNP, U2-type prespliceosome, cytoplasm, nucleus, spliceosomal complex	molecular_function, protein binding		
YPL214C	THI6	Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000006135]	metabolic process, thiamine biosynthetic process	cytoplasm, cytosol	ATP binding, catalytic activity, hydroxyethylthiazole kinase activity, kinase activity, metal ion binding, nucleotide binding, thiamine-phosphate diphosphorylase activity, transferase activity		
YPL215W	CBP3	Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p [Source:SGD;Acc:S000006136]	mitochondrial respiratory chain complex III assembly	integral to membrane, integral to mitochondrial membrane, membrane, mitochondrial membrane, mitochondrion	molecular_function		
YPL216W	YPL216W	Putative protein of unknown function; YPL216W is not an essential gene [Source:SGD;Acc:S000006137]	biological_process, chromatin modification	cellular_component, nucleus	molecular_function		
YPL217C	BMS1	GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p [Source:SGD;Acc:S000006138]	rRNA processing, ribosome assembly, ribosome biogenesis	90S preribosome, cytoplasm, mitochondrion, nucleolus, nucleus	ATP binding, GTP binding, GTPase activity, U3 snoRNA binding, nucleotide binding		
YPL218W	SAR1	GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport [Source:SGD;Acc:S000006139]	intracellular protein transport, protein transport, regulation of COPII vesicle coating, transport, vesicle-mediated transport	COPII vesicle coat, ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular, membrane	GTP binding, GTPase activity, hydrolase activity, nucleotide binding		
YPL219W	PCL8	Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation [Source:SGD;Acc:S000006140]	carbohydrate metabolic process, glycogen metabolic process, negative regulation of glycogen biosynthetic process	cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus	cyclin-dependent protein kinase regulator activity		
YPL220W	RPL1A	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal [Source:SGD;Acc:S000006141]	RNA processing, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YPL221W	FLC1	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance [Source:SGD;Acc:S000006142]	FAD transport, fungal-type cell wall biogenesis, protein folding, transport	cellular bud neck, endoplasmic reticulum, endoplasmic reticulum membrane, fungal-type vacuole, integral to membrane, membrane	FAD transmembrane transporter activity		
YPL222C-A	YPL222C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028722]					
YPL222W	FMP40	Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000006143]	biological_process	mitochondrion	molecular_function		
YPL223C	GRE1	Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway [Source:SGD;Acc:S000006144]	biological_process, response to stress	cytoplasm	molecular_function		
YPL224C	MMT2	Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p [Source:SGD;Acc:S000006145]	cation transport, cellular iron ion homeostasis, ion transport, iron ion transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial membrane, mitochondrion	cation transmembrane transporter activity, molecular_function		
YPL225W	YPL225W	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000006146]	biological_process	cytoplasm, ribosome	molecular_function		
YPL226W	NEW1	ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction [Source:SGD;Acc:S000006147]	chromatin assembly or disassembly, mRNA transport, poly(A)+ mRNA export from nucleus, ribosomal small subunit biogenesis, transport	chromatin, cytoplasm, mitochondrion, nucleus, polysome	ATP binding, ATPase activity, binding, chromatin binding, nucleoside-triphosphatase activity, nucleotide binding		
YPL227C	ALG5	UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum [Source:SGD;Acc:S000006148]	protein N-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	dolichyl-phosphate beta-glucosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YPL228W	CET1	Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide [Source:SGD;Acc:S000006149]	mRNA capping, mRNA processing	mRNA cap methyltransferase complex, nucleus	hydrolase activity, polynucleotide 5'-phosphatase activity		
YPL229W	YPL229W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene [Source:SGD;Acc:S000006150]	biological_process	cytoplasm	molecular_function		
YPL230W	USV1	Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis [Source:SGD;Acc:S000006151]	carbon catabolite activation of transcription from RNA polymerase II promoter, regulation of transcription from RNA polymerase II promoter, response to salt stress	intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YPL231W	FAS2	Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities [Source:SGD;Acc:S000006152]	biosynthetic process, fatty acid biosynthetic process, lipid biosynthetic process, macromolecule biosynthetic process, metabolic process, oxidation-reduction process	cytoplasm, cytosol, fatty acid synthase complex, mitochondrion	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity, 3-oxoacyl-[acyl-carrier-protein] synthase activity, binding, catalytic activity, fatty acid synthase activity, fatty-acyl-CoA synthase activity, holo-[acyl-carrier-protein] synthase activity, magnesium ion binding, oxidoreductase activity, transferase activity		
YPL232W	SSO1	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p [Source:SGD;Acc:S000006153]	Golgi to plasma membrane transport, ascospore formation, ascospore-type prospore formation, cellular membrane fusion, intracellular protein transport, vesicle-mediated transport	SNARE complex, fungal-type vacuole membrane, integral to membrane, membrane, plasma membrane, plasma membrane enriched fraction, prospore membrane	SNAP receptor activity, phosphatidic acid binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding		
YPL233W	NSL1	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation [Source:SGD;Acc:S000006154]	cell cycle, cell division, chromosome segregation, mitosis	chromosome, centromeric region, condensed chromosome kinetochore, kinetochore, nuclear MIS12/MIND type complex, nucleus, spindle pole	molecular_function		
YPL234C	VMA11	Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen [Source:SGD;Acc:S000006155]	ATP hydrolysis coupled proton transport, ATP synthesis coupled proton transport, ion transport, proton transport, transport, vacuolar acidification	fungal-type vacuole, integral to membrane, membrane, proton-transporting V-type ATPase, V0 domain, proton-transporting two-sector ATPase complex, proton-transporting domain, vacuolar membrane, vacuolar proton-transporting V-type ATPase, V0 domain, vacuole	hydrogen ion transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism		
YPL235W	RVB2	Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as reptin; member of the RUVB-like protein family [Source:SGD;Acc:S000006156]	DNA repair, chromatin modification, chromatin remodeling, rRNA processing, regulation of transcription from RNA polymerase II promoter, response to DNA damage stimulus, snoRNA metabolic process	ASTRA complex, Ino80 complex, Swr1 complex, chromatin remodeling complex, nucleoplasm, nucleus	ATP binding, ATP-dependent 3'-5' DNA helicase activity, ATPase activity, DNA helicase activity, helicase activity, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding		
YPL236C	YPL236C		biological_process, protein phosphorylation	fungal-type vacuole membrane, membrane, vacuolar membrane, vacuole	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPL237W	SUI3	Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding [Source:SGD;Acc:S000006158]	translation, translational initiation	eukaryotic translation initiation factor 2 complex, multi-eIF complex, ribosome	metal ion binding, translation initiation factor activity		
YPL238C	YPL238C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W [Source:SGD;Acc:S000006159]					
YPL239W	YAR1	Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock [Source:SGD;Acc:S000006160]	cellular response to oxidative stress, response to osmotic stress, ribosomal small subunit biogenesis	cytoplasm	molecular_function, protein binding		
YPL240C	HSP82	Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p [Source:SGD;Acc:S000006161]	'de novo' protein folding, positive regulation of telomere maintenance via telomerase, proteasome assembly, protein folding, protein refolding, protein targeting to mitochondrion, response to osmotic stress, response to stress	cytoplasm	ATP binding, ATPase activity, coupled, nucleotide binding, unfolded protein binding		
YPL241C	CIN2	GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 [Source:SGD;Acc:S000006162]	protein folding	cellular_component, cytoplasm, cytoskeleton, microtubule	GTPase activator activity		
YPL242C	IQG1	Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family [Source:SGD;Acc:S000006163]	actin filament organization, cell cycle, cell division, cytokinesis, regulation of small GTPase mediated signal transduction, response to osmotic stress, signal transduction, small GTPase mediated signal transduction	cellular bud neck, cellular bud neck contractile ring, intracellular	GTPase activator activity, Ras GTPase activator activity, actin binding, cytoskeletal protein binding, protein binding		
YPL243W	SRP68	Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane [Source:SGD;Acc:S000006164]	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, protein targeting to ER	cytoplasm, nucleus, ribonucleoprotein complex, signal recognition particle, endoplasmic reticulum targeting	RNA binding, signal sequence binding		
YPL244C	HUT1	Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 [Source:SGD;Acc:S000006165]	UDP-galactose transport, UDP-glucose transport, carbohydrate transport, transmembrane transport, transport	cellular_component, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	UDP-galactose transmembrane transporter activity		
YPL245W	YPL245W	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm [Source:SGD;Acc:S000006166]	biological_process	cytoplasm, nucleus	molecular_function, nucleoside-triphosphatase activity, nucleotide binding		
YPL246C	RBD2	Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p [Source:SGD;Acc:S000006167]	biological_process	COPI-coated vesicle, Golgi apparatus, Golgi membrane, integral to membrane, membrane	hydrolase activity, molecular_function, peptidase activity, serine-type peptidase activity		
YPL247C	YPL247C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest [Source:SGD;Acc:S000006168]	biological_process	cytoplasm, nucleus	molecular_function, protein binding		
YPL248C	GAL4	DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p [Source:SGD;Acc:S000006169]	carbohydrate metabolic process, galactose metabolic process, positive regulation of transcription by galactose, regulation of transcription, DNA-dependent	nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YPL249C	GYP5	GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p [Source:SGD;Acc:S000006170]	ER to Golgi vesicle-mediated transport, exocytosis, protein transport, regulation of Rab GTPase activity, transport, vesicle-mediated transport	Golgi-associated vesicle, cellular bud, cellular bud neck, cellular bud tip, cytoplasm, cytosol, incipient cellular bud site, intracellular, membrane fraction, plasma membrane, soluble fraction	GTPase activator activity, Rab GTPase activator activity		
YPL249C-A	RPL36B	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA [Source:SGD;Acc:S000006438]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, structural constituent of ribosome		
YPL250C	ICY2	Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate [Source:SGD;Acc:S000006171]	mitochondrion degradation	cellular_component	molecular_function		
YPL250W-A	YPL250W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified ORF RPL36B/YPL249C-A; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028589]					
YPL251W	YPL251W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C [Source:SGD;Acc:S000006172]					
YPL252C	YAH1	Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin [Source:SGD;Acc:S000006173]	electron transport chain, heme a biosynthetic process, iron-sulfur cluster assembly, transport, ubiquinone biosynthetic process	mitochondrial matrix, mitochondrion	2 iron, 2 sulfur cluster binding, electron carrier activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor		
YPL253C	VIK1	Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p [Source:SGD;Acc:S000006174]	microtubule-based process, mitotic sister chromatid cohesion	cytoplasm, cytoskeleton, kinesin complex, nucleus, spindle pole body	microtubule motor activity		
YPL254W	HFI1	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions [Source:SGD;Acc:S000006175]	chromatin modification, histone acetylation, transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex, SAGA complex, SLIK (SAGA-like) complex, nucleus	transcription coactivator activity, transcription cofactor activity		
YPL255W	BBP1	Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p [Source:SGD;Acc:S000006176]	microtubule nucleation, spindle pole body duplication in nuclear envelope	spindle pole body	structural constituent of cytoskeleton		
YPL256C	CLN2	G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) [Source:SGD;Acc:S000006177]	cell cycle, cell division, re-entry into mitotic cell cycle after pheromone arrest, regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex, cytoplasm, nucleus	cyclin-dependent protein kinase regulator activity		
YPL257W	YPL257W	Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene [Source:SGD;Acc:S000006178]	biological_process, cell cycle	cellular_component, integral to membrane, membrane	molecular_function		
YPL257W-A	YPL257W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007357]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YPL257W-B	YPL257W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007358]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YPL258C	THI21	Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; Thi20p also has this activity [Source:SGD;Acc:S000006179]	thiamine biosynthetic process	cellular_component	ATP binding, hydroxymethylpyrimidine kinase activity, kinase activity, nucleotide binding, phosphomethylpyrimidine kinase activity, transferase activity		
YPL259C	APM1	Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting [Source:SGD;Acc:S000006180]	Golgi to vacuole transport, intracellular protein transport, transport, vesicle-mediated transport	AP-1 adaptor complex, clathrin adaptor complex, clathrin coated vesicle membrane, coated pit, cytoplasmic membrane-bounded vesicle, cytoplasmic vesicle, membrane	clathrin binding, protein binding		
YPL260W	YPL260W	Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene [Source:SGD;Acc:S000006181]	biological_process	cytoplasm, nucleus	molecular_function		
YPL261C	YPL261C	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W [Source:SGD;Acc:S000006182]					
YPL262W	FUM1	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria [Source:SGD;Acc:S000006183]	fumarate metabolic process, tricarboxylic acid cycle	cytoplasm, cytosol, mitochondrial matrix, mitochondrion, tricarboxylic acid cycle enzyme complex	catalytic activity, fumarate hydratase activity, lyase activity		
YPL263C	KEL3	Cytoplasmic protein of unknown function [Source:SGD;Acc:S000006184]	biological_process	cytoplasm	molecular_function		
YPL264C	YPL264C	Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene [Source:SGD;Acc:S000006185]	biological_process	integral to membrane, membrane	molecular_function		
YPL265W	DIP5	Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly [Source:SGD;Acc:S000006186]	amino acid transport, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	amino acid transmembrane transporter activity		
YPL266W	DIM1	Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing [Source:SGD;Acc:S000006187]	rRNA modification, rRNA processing, ribosome biogenesis	90S preribosome, cytoplasm, nucleolus, nucleus	RNA binding, methyltransferase activity, rRNA (adenine) methyltransferase activity, rRNA (adenine-N6,N6-)-dimethyltransferase activity, rRNA methyltransferase activity, transferase activity		
YPL267W	ACM1	Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein [Source:SGD;Acc:S000006188]	cell cycle, cell division, mitosis, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytoplasm, nucleus	ubiquitin-protein ligase inhibitor activity		
YPL268W	PLC1	Phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes [Source:SGD;Acc:S000006189]	inositol phosphate biosynthetic process, intracellular signal transduction, lipid catabolic process, lipid metabolic process, phospholipid catabolic process, protein localization to kinetochore, signal transduction, signal transduction involved in filamentous growth	chromosome, centromeric region, condensed nuclear chromosome kinetochore	calcium ion binding, hydrolase activity, phosphatidylinositol phospholipase C activity, phospholipase C activity, phosphoric diester hydrolase activity, protein binding, signal transducer activity		
YPL269W	KAR9	Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase [Source:SGD;Acc:S000006190]	karyogamy, nuclear migration along microtubule	cell cortex, cytoplasm, cytoskeleton, mating projection tip, microtubule, nucleus, spindle pole body	molecular_function		
YPL270W	MDL2	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis [Source:SGD;Acc:S000006191]	oligopeptide export from mitochondrion, oligopeptide transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding, oligopeptide-transporting ATPase activity, transporter activity		
YPL271W	ATP15	Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [Source:SGD;Acc:S000006192]	ATP biosynthetic process, ATP synthesis coupled proton transport, ion transport, proton transport, transport	membrane, mitochondrial inner membrane, mitochondrial proton-transporting ATP synthase complex, catalytic core F(1), mitochondrial proton-transporting ATP synthase, central stalk, mitochondrion, proton-transporting ATP synthase complex, catalytic core F(1)	ATPase activity, hydrogen ion transporting ATP synthase activity, rotational mechanism, hydrolase activity, proton-transporting ATPase activity, rotational mechanism		
YPL272C	YPL272C	Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene [Source:SGD;Acc:S000006193]	alcohol metabolic process, biological_process	cellular_component	alcohol O-acetyltransferase activity, molecular_function		
YPL273W	SAM4	S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio [Source:SGD;Acc:S000006194]	L-methionine biosynthetic process from S-adenosylmethionine, S-adenosylhomocysteine metabolic process, cellular amino acid biosynthetic process, homocysteine metabolic process, methionine biosynthetic process	cytoplasm, nucleus	homocysteine S-methyltransferase activity, metal ion binding, methyltransferase activity, transferase activity		
YPL274W	SAM3	High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p [Source:SGD;Acc:S000006195]	S-adenosylmethionine transport, amino acid transport, putrescine transport, spermidine transport, transmembrane transport, transport	endoplasmic reticulum, integral to membrane, membrane, plasma membrane	S-adenosylmethionine transmembrane transporter activity, amino acid transmembrane transporter activity, putrescine transmembrane transporter activity, spermidine transmembrane transporter activity		
YPL277C	YPL277C	Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels [Source:SGD;Acc:S000006198]	biological_process	membrane fraction	molecular_function		
YPL278C	YPL278C	Putative protein of unknown function; gene expression regulated by copper levels [Source:SGD;Acc:S000006199]	biological_process	cellular_component	molecular_function		
YPL279C	YPL279C	Putative protein of unknown function [Source:SGD;Acc:S000006200]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YPL280W	HSP32	Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease [Source:SGD;Acc:S000006201]	biological_process, response to stress	cellular_component	cysteine-type peptidase activity, hydrolase activity, peptidase activity, unfolded protein binding		
YPL281C	ERR2	Protein of unknown function, has similarity to enolases [Source:SGD;Acc:S000006202]	biological_process, glycolysis	cellular_component, phosphopyruvate hydratase complex	lyase activity, magnesium ion binding, metal ion binding, phosphopyruvate hydratase activity		
YPL282C	PAU22	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau21p; encodes 2 proteins that are translated from 2 different start codons [Source:SGD;Acc:S000006203]	biological_process, response to stress	cellular_component	molecular_function		
YPL283C	YRF1-7	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000006204]	telomere maintenance via recombination	mitochondrion	ATP binding, ATP-dependent helicase activity, DNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
YPL283W-A	YPL283W-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028723]					
YPL283W-B	YPL283W-B	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028724]					
YPR001W	CIT3	Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate [Source:SGD;Acc:S000006205]	cellular carbohydrate metabolic process, propionate catabolic process, 2-methylcitrate cycle, propionate metabolic process, tricarboxylic acid cycle	mitochondrion	2-methylcitrate synthase activity, citrate (Si)-synthase activity, transferase activity, transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer		
YPR002C-A	YPR002C-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the Ty1 long terminal repeat, YPRWdelta12 [Source:SGD;Acc:S000007254]					
YPR002W	PDH1	Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate [Source:SGD;Acc:S000006206]	propionate catabolic process, propionate catabolic process, 2-methylcitrate cycle, propionate metabolic process	cytoplasm, mitochondrial outer membrane, mitochondrion	2 iron, 2 sulfur cluster binding, 2-methylcitrate dehydratase activity, iron-sulfur cluster binding, lyase activity, metal ion binding, molecular_function		
YPR003C	YPR003C	Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene [Source:SGD;Acc:S000006207]	biological_process, sulfate transport, transmembrane transport, transport	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function, secondary active sulfate transmembrane transporter activity, transporter activity		
YPR004C	AIM45	Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response [Source:SGD;Acc:S000006208]	biological_process, electron transport chain, transport	mitochondrial matrix, mitochondrion	electron carrier activity, flavin adenine dinucleotide binding, molecular_function		
YPR005C	HAL1	Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p [Source:SGD;Acc:S000006209]	positive regulation of transcription from RNA polymerase II promoter, response to salt stress, response to stress	cytoplasm	molecular_function		
YPR006C	ICL2	2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol [Source:SGD;Acc:S000006210]	carboxylic acid metabolic process, metabolic process, propionate metabolic process, threonine catabolic process	mitochondrial matrix, mitochondrion	catalytic activity, isocitrate lyase activity, lyase activity, methylisocitrate lyase activity		
YPR007C	REC8	Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p [Source:SGD;Acc:S000006211]	chromosome segregation, meiosis, meiotic sister chromatid cohesion, protein localization to chromosome, centromeric region, reciprocal meiotic recombination, synaptonemal complex assembly	chromosome, chromosome, centromeric region, condensed nuclear chromosome, condensed nuclear chromosome, centromeric region, nucleus	molecular_function		
YPR008W	HAA1	Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stress [Source:SGD;Acc:S000006212]	regulation of transcription, DNA-dependent, response to acid, transcription initiation from RNA polymerase II promoter	nucleus	DNA binding, copper ion binding, metal ion binding, sequence-specific DNA binding transcription factor activity		
YPR009W	SUT2	Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p [Source:SGD;Acc:S000006213]	regulation of transcription from RNA polymerase II promoter, sterol transport	nucleus	sequence-specific DNA binding		
YPR010C	RPA135	RNA polymerase I second largest subunit A135 [Source:SGD;Acc:S000006214]	transcription of nuclear rRNA large RNA polymerase I transcript	DNA-directed RNA polymerase I complex, nucleolus, nucleus	DNA binding, DNA-directed RNA polymerase activity, metal ion binding, nucleotidyltransferase activity, ribonucleoside binding, transferase activity		
YPR010C-A	YPR010C-A	Putative protein of unknown function; conserved among Saccharomyces sensu stricto species [Source:SGD;Acc:S000122558]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YPR011C	YPR011C	Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000006215]	transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, transporter activity		
YPR012W	YPR012W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene [Source:SGD;Acc:S000006216]					
YPR013C	YPR013C	Putative zinc finger protein; YPR013C is not an essential gene [Source:SGD;Acc:S000006217]	biological_process	cellular_component, intracellular	metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YPR014C	YPR014C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene [Source:SGD;Acc:S000006218]					
YPR015C	YPR015C	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest [Source:SGD;Acc:S000006219]	biological_process	cellular_component, intracellular	metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YPR016C	TIF6	Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits [Source:SGD;Acc:S000006220]	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), mature ribosome assembly, rRNA processing, ribosomal large subunit biogenesis, ribosomal subunit export from nucleus, translation	cytoplasm, nucleolus, nucleus, preribosome, large subunit precursor	ribosomal large subunit binding, ribosome binding, translation initiation factor activity		
YPR016W-A	YPR016W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007630]					
YPR017C	DSS4	Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol [Source:SGD;Acc:S000006221]	post-Golgi vesicle-mediated transport, protein transport, small GTPase mediated signal transduction, transport	membrane fraction, soluble fraction	guanyl-nucleotide exchange factor activity, zinc ion binding		
YPR018W	RLF2	Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin [Source:SGD;Acc:S000006222]	DNA replication-dependent nucleosome assembly, chromatin silencing at silent mating-type cassette	CAF-1 complex, chromosome, centromeric region, nucleus	chromatin binding		
YPR019W	MCM4	Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication; accumulates in the nucleus in G1; homolog of S. pombe Cdc21p [Source:SGD;Acc:S000006223]	DNA replication, DNA strand elongation involved in DNA replication, DNA unwinding involved in replication, DNA-dependent DNA replication initiation, S phase of mitotic cell cycle, cell cycle, double-strand break repair via break-induced replication, pre-replicative complex assembly	DNA replication preinitiation complex, MCM complex, cytoplasm, nuclear replication fork, nucleus, pre-replicative complex, replication fork protection complex	ATP binding, ATP-dependent 3'-5' DNA helicase activity, DNA binding, DNA replication origin binding, four-way junction helicase activity, nucleotide binding, single-stranded DNA binding, single-stranded DNA-dependent ATPase activity		
YPR020W	ATP20	Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex [Source:SGD;Acc:S000006224]	ATP biosynthetic process, ATP synthesis coupled proton transport, cristae formation, ion transport, protein complex assembly, protein oligomerization, proton transport, transport	membrane, mitochondrial membrane, mitochondrial proton-transporting ATP synthase complex, coupling factor F(o), mitochondrion, proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism, structural molecule activity		
YPR021C	AGC1	Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis [Source:SGD;Acc:S000006225]	L-glutamate transport, amino acid transport, aspartate transport, cellular nitrogen compound biosynthetic process, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	L-aspartate transmembrane transporter activity, L-glutamate transmembrane transporter activity, antiporter activity, binding, uniporter activity		
YPR022C	YPR022C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000006226]	biological_process	cytoplasm, intracellular, nucleus	DNA binding, metal ion binding, nucleic acid binding, sequence-specific DNA binding, zinc ion binding		
YPR023C	EAF3	Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000006227]	DNA repair, chromatin assembly or disassembly, chromatin modification, histone acetylation, histone deacetylation, negative regulation of antisense RNA transcription, negative regulation of transcription, DNA-dependent, regulation of DNA-dependent DNA replication initiation, regulation of transcription from RNA polymerase II promoter, response to DNA damage stimulus, transcription elongation from RNA polymerase II promoter	NuA4 histone acetyltransferase complex, Rpd3S complex, chromatin, histone acetyltransferase complex, nucleus	chromatin binding, histone acetyltransferase activity, histone deacetylase activity		
YPR024W	YME1	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover [Source:SGD;Acc:S000006228]	chronological cell aging, misfolded or incompletely synthesized protein catabolic process, mitochondrion organization, protein catabolic process, proteolysis	i-AAA complex, membrane, mitochondrial inner membrane, mitochondrion	ATP binding, ATP-dependent peptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, nucleoside-triphosphatase activity, nucleotide binding, peptidase activity		
YPR025C	CCL1	Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters [Source:SGD;Acc:S000006229]	cell cycle, phosphorylation of RNA polymerase II C-terminal domain	TFIIK complex, holo TFIIH complex, mitochondrion			
YPR026W	ATH1	Acid trehalase required for utilization of extracellular trehalose [Source:SGD;Acc:S000006230]	carbohydrate metabolic process, metabolic process, response to stress, trehalose catabolic process	cell wall-bounded periplasmic space, fungal-type cell wall, fungal-type vacuole, vacuole	alpha,alpha-trehalase activity, carbohydrate binding, catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds		
YPR027C	YPR027C	Putative protein of unknown function [Source:SGD;Acc:S000006231]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YPR028W	YOP1	Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes [Source:SGD;Acc:S000006232]	endoplasmic reticulum organization, nuclear pore complex assembly, vesicle-mediated transport	Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	protein binding		
YPR029C	APL4	Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport [Source:SGD;Acc:S000006233]	Golgi to vacuole transport, intracellular protein transport, protein transport, vesicle-mediated transport	AP-1 adaptor complex, Golgi apparatus, Golgi apparatus part, Golgi membrane, clathrin adaptor complex, clathrin coated vesicle membrane, cytoplasm, cytoplasmic vesicle, membrane, membrane coat	binding, clathrin binding, protein transporter activity		
YPR030W	CSR2	Nuclear protein proposed to regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p [Source:SGD;Acc:S000006234]	fungal-type cell wall organization, regulation of transcription from RNA polymerase II promoter, ubiquitin-dependent endocytosis	cytoplasm, nucleus	ubiquitin protein ligase binding		
YPR031W	NTO1	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3 [Source:SGD;Acc:S000006235]	histone acetylation	NuA3 histone acetyltransferase complex, cytoplasm, nucleus	histone acetyltransferase activity, metal ion binding, methylated histone residue binding, protein binding, zinc ion binding		
YPR032W	SRO7	Effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor [Source:SGD;Acc:S000006236]	Golgi to plasma membrane transport, establishment of cell polarity, exocytosis, small GTPase mediated signal transduction	cytosol, plasma membrane	Rab GTPase binding, SNARE binding, protein binding		
YPR033C	HTS1	Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence [Source:SGD;Acc:S000006237]	histidyl-tRNA aminoacylation, mitochondrial translation, tRNA aminoacylation for protein translation, translation	cytoplasm, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, histidine-tRNA ligase activity, ligase activity, nucleotide binding		
YPR034W	ARP7	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation [Source:SGD;Acc:S000006238]	ATP-dependent chromatin remodeling, chromatin modification, chromatin organization, nucleosome disassembly, nucleosome mobilization, transcription elongation from RNA polymerase II promoter	RSC complex, SWI/SNF complex, nucleus	DNA-dependent ATPase activity		
YPR035W	GLN1	Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation [Source:SGD;Acc:S000006239]	glutamine biosynthetic process, nitrogen compound metabolic process	cytoplasm	ATP binding, catalytic activity, glutamate-ammonia ligase activity, ligase activity, nucleotide binding		
YPR036W	VMA13	Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase [Source:SGD;Acc:S000006240]	ATP hydrolysis coupled proton transport, ATP synthesis coupled proton transport, ion transport, proton transport, transport, vacuolar acidification	fungal-type vacuole membrane, membrane, vacuolar membrane, vacuolar proton-transporting V-type ATPase, V1 domain, vacuole	binding, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances, proton-transporting ATPase activity, rotational mechanism		
YPR036W-A	YPR036W-A	Protein of unknown function; transcription is regulated by Pdr1p [Source:SGD;Acc:S000028425]	response to drug	cellular_component	molecular_function		
YPR037C	ERV2	Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER [Source:SGD;Acc:S000006241]	oxidation-reduction process, protein thiol-disulfide exchange	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome	oxidoreductase activity, thiol oxidase activity		
YPR038W	IRC16	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000006242]					
YPR039W	YPR039W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W [Source:SGD;Acc:S000006243]					
YPR040W	TIP41	Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway [Source:SGD;Acc:S000006244]	negative regulation of signal transduction, signal transduction	cytoplasm, nucleus	molecular_function		
YPR041W	TIF5	Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2 [Source:SGD;Acc:S000006245]	RNA metabolic process, mature ribosome assembly, negative regulation of translational initiation, regulation of translational initiation, translation, translational initiation	cytosolic small ribosomal subunit, multi-eIF complex	GDP-dissociation inhibitor activity, GTP binding, GTPase activator activity, binding, nucleotide binding, translation initiation factor activity		
YPR042C	PUF2	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins [Source:SGD;Acc:S000006246]	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	cytoplasm	RNA binding, binding, mRNA binding, nucleic acid binding, nucleotide binding		
YPR043W	RPL43A	Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype [Source:SGD;Acc:S000006247]	translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	metal ion binding, structural constituent of ribosome		
YPR044C	OPI11	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO [Source:SGD;Acc:S000006248]					
YPR045C	THP3	Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes [Source:SGD;Acc:S000006249]	nuclear mRNA splicing, via spliceosome	nucleus, transcriptionally active chromatin	molecular_function		
YPR046W	MCM16	Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA [Source:SGD;Acc:S000006250]	cell cycle, cell division, chromosome segregation, establishment of mitotic sister chromatid cohesion, meiosis, mitosis	chromosome, centromeric region, condensed chromosome kinetochore, condensed nuclear chromosome kinetochore, kinetochore, nucleus	molecular_function		
YPR047W	MSF1	Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase [Source:SGD;Acc:S000006251]	mitochondrial phenylalanyl-tRNA aminoacylation, phenylalanyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, tRNA processing, translation	cytoplasm, mitochondrial matrix, mitochondrion	ATP binding, aminoacyl-tRNA ligase activity, ligase activity, magnesium ion binding, nucleotide binding, phenylalanine-tRNA ligase activity, tRNA binding		
YPR048W	TAH18	Conserved NAPDH-dependent diflavin reductase, component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress [Source:SGD;Acc:S000006252]	iron-sulfur cluster assembly, oxidation-reduction process	mitochondrion	FMN binding, iron ion binding, oxidoreductase activity, oxidoreductase activity, acting on NADH or NADPH		
YPR049C	ATG11	Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) [Source:SGD;Acc:S000006253]	CVT pathway, autophagy, mitochondrion degradation, peroxisome degradation, piecemeal microautophagy of nucleus, protein localization to pre-autophagosomal structure, protein transport, transport	extrinsic to membrane, membrane, pre-autophagosomal structure	protein complex scaffold		
YPR050C	YPR050C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W [Source:SGD;Acc:S000006254]					
YPR051W	MAK3	Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus [Source:SGD;Acc:S000006255]	N-terminal protein amino acid acetylation, metabolic process	NatC complex, cytoplasm, nucleus	N-acetyltransferase activity, acyltransferase activity, peptide alpha-N-acetyltransferase activity, transferase activity		
YPR052C	NHP6A	High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2 [Source:SGD;Acc:S000006256]	DNA repair, DNA replication-independent nucleosome organization, RNA polymerase II transcriptional preinitiation complex assembly, RNA polymerase III transcriptional preinitiation complex assembly, chromatin remodeling, mismatch repair, response to DNA damage stimulus	MutSalpha complex, chromosome, nucleus	DNA bending activity, DNA binding, nucleosome binding, protein binding, sequence-specific DNA binding		
YPR053C	YPR053C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C [Source:SGD;Acc:S000006257]					
YPR054W	SMK1	Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p [Source:SGD;Acc:S000006258]	ascospore wall assembly, cellular cell wall organization, negative regulation of sporulation resulting in formation of a cellular spore, protein phosphorylation, regulation of cell shape, sporulation resulting in formation of a cellular spore	mitochondrion	ATP binding, MAP kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPR055W	SEC8	Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis [Source:SGD;Acc:S000006259]	Golgi to plasma membrane transport, bipolar cellular bud site selection, cytokinesis, exocytosis, protein transport, transport, vesicle docking involved in exocytosis, vesicle fusion	cellular bud tip, cytoplasm, exocyst, incipient cellular bud site, mating projection tip, membrane, plasma membrane, site of polarized growth	molecular_function		
YPR056W	TFB4	Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p [Source:SGD;Acc:S000006260]	DNA repair, nucleotide-excision repair, phosphorylation of RNA polymerase II C-terminal domain, regulation of transcription, DNA-dependent, response to DNA damage stimulus	core TFIIH complex, holo TFIIH complex, nucleotide-excision repair factor 3 complex, nucleus	metal ion binding		
YPR057W	BRR1	snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed [Source:SGD;Acc:S000006261]	RNA splicing, mRNA processing, spliceosome assembly	nucleus, small nuclear ribonucleoprotein complex, spliceosomal complex	RNA binding		
YPR058W	YMC1	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p [Source:SGD;Acc:S000006262]	mitochondrial transport, transmembrane transport, transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	binding, organic acid transmembrane transporter activity		
YPR059C	YPR059C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W [Source:SGD;Acc:S000006263]					
YPR060C	ARO7	Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis [Source:SGD;Acc:S000006264]	aromatic amino acid family biosynthetic process, cellular amino acid biosynthetic process, chorismate metabolic process	cytoplasm, nucleus	catalytic activity, chorismate mutase activity, isomerase activity		
YPR061C	JID1	Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae [Source:SGD;Acc:S000006265]	biological_process, protein folding	integral to membrane, membrane, mitochondrial membrane, mitochondrion	heat shock protein binding, molecular_function, unfolded protein binding		
YPR062W	FCY1	Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) [Source:SGD;Acc:S000006266]	cytidine metabolic process, cytosine metabolic process, pyrimidine-containing compound salvage	cytoplasm, nucleus	catalytic activity, cytosine deaminase activity, hydrolase activity, metal ion binding, zinc ion binding		
YPR063C	YPR063C	ER-localized protein of unknown function [Source:SGD;Acc:S000006267]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YPR064W	YPR064W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006268]					
YPR065W	ROX1	Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity [Source:SGD;Acc:S000006269]		nuclear chromatin, nucleus	DNA bending activity, DNA binding, protein binding, sequence-specific DNA binding		
YPR066W	UBA3	Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000006270]	metabolic process, protein modification process, protein neddylation	cytoplasm	ATP binding, NEDD8 activating enzyme activity, binding, catalytic activity, ligase activity, nucleotide binding, small protein activating enzyme activity		
YPR067W	ISA2	Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations [Source:SGD;Acc:S000006271]	biotin biosynthetic process, iron-sulfur cluster assembly, protein maturation	mitochondrial intermembrane space, mitochondrial matrix, mitochondrion	iron-sulfur cluster binding, molecular_function, structural molecule activity		
YPR068C	HOS1	Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex [Source:SGD;Acc:S000006272]	chromatin modification, chromatin organization, peptidyl-lysine deacetylation, protein deacetylation, regulation of transcription, DNA-dependent	histone deacetylase complex, nucleus	histone deacetylase activity, hydrolase activity, protein deacetylase activity		
YPR069C	SPE3	Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells [Source:SGD;Acc:S000006273]	pantothenate biosynthetic process, spermidine biosynthetic process	cytoplasm, nucleus	catalytic activity, spermidine synthase activity, transferase activity		
YPR070W	MED1	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000006274]	nuclear-transcribed mRNA catabolic process, non-stop decay, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus			
YPR071W	YPR071W	Putative membrane protein; YPR071W is not an essential gene [Source:SGD;Acc:S000006275]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YPR072W	NOT5	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation [Source:SGD;Acc:S000006276]	nuclear-transcribed mRNA poly(A) tail shortening, protein ubiquitination, regulation of transcription from RNA polymerase II promoter, transcription elongation from RNA polymerase II promoter	CCR4-NOT core complex, cytoplasm, nucleus	ubiquitin-protein ligase activity		
YPR073C	LTP1	Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine [Source:SGD;Acc:S000006277]	protein dephosphorylation	cytoplasm, nucleus	acid phosphatase activity, hydrolase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity		
YPR074C	TKL1	Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids [Source:SGD;Acc:S000006278]	metabolic process, pentose-phosphate shunt	cytoplasm	catalytic activity, metal ion binding, transferase activity, transketolase activity		
YPR074W-A	YPR074W-A	Hypothetical protein identified by homology [Source:SGD;Acc:S000007631]					
YPR075C	OPY2	Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone [Source:SGD;Acc:S000006279]	cell cycle arrest in response to pheromone, osmosensory signaling pathway	cytoplasm, fungal-type vacuole, integral to membrane, membrane, plasma membrane, vacuolar membrane, vacuole	molecular_function		
YPR076W	YPR076W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006280]					
YPR077C	YPR077C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1 [Source:SGD;Acc:S000006281]					
YPR078C	YPR078C	Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible [Source:SGD;Acc:S000006282]	biological_process	cellular_component	molecular_function		
YPR079W	MRL1	Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases [Source:SGD;Acc:S000006283]	protein transport, transport, vacuolar transport	Golgi apparatus, cytoplasm, endosome, endosome membrane, integral to membrane, late endosome, membrane	signal sequence binding		
YPR080W	TEF1	Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus [Source:SGD;Acc:S000006284]	tRNA export from nucleus, translation, translational elongation	cytoplasm, cytoskeleton, eukaryotic translation elongation factor 1 complex, mitochondrion, ribosome	GDP binding, GTP binding, GTPase activity, actin binding, nucleotide binding, translation elongation factor activity		
YPR081C	GRS2	Protein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase; cannot substitute for Grs1p; possible pseudogene that is expressed at very low levels [Source:SGD;Acc:S000006285]	glycyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation	cytoplasm	ATP binding, aminoacyl-tRNA ligase activity, glycine-tRNA ligase activity, ligase activity, nucleotide binding		
YPR082C	DIB1	17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein [Source:SGD;Acc:S000006286]	RNA splicing, cell cycle, cell division, mRNA processing, mitosis, nuclear mRNA splicing, via spliceosome	U4/U6 x U5 tri-snRNP complex, U5 snRNP, nucleus, spliceosomal complex	molecular_function		
YPR083W	MDM36	Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission [Source:SGD;Acc:S000006287]	mitochondrial fission, mitochondrion organization	cytoplasm, mitochondrion	molecular_function		
YPR084W	YPR084W	Putative protein of unknown function [Source:SGD;Acc:S000006288]	biological_process	cellular_component	molecular_function		
YPR085C	ASA1	Putative protein of unknown function; subunit of the ASTRA complex (Rvb1p, Rvb2p, Tra1p, Tti1p, Tti2, Asa1p and Tra1p) which is part of the chromatin remodeling machinery [Source:SGD;Acc:S000006289]	biological_process, chromatin modification	ASTRA complex, nucleus	molecular_function, protein binding		
YPR086W	SUA7	Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II [Source:SGD;Acc:S000006290]	regulation of transcription, DNA-dependent, transcription initiation from RNA polymerase II promoter, transcription initiation, DNA-dependent, translational initiation	nucleoplasm, nucleus	metal ion binding, translation initiation factor activity, zinc ion binding		
YPR087W	VPS69	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect [Source:SGD;Acc:S000006291]					
YPR088C	SRP54	Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain [Source:SGD;Acc:S000006292]	SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, protein targeting to ER	cytoplasm, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting	7S RNA binding, GTP binding, GTPase activator activity, RNA binding, nucleoside-triphosphatase activity, nucleotide binding, signal sequence binding		
YPR089W	YPR089W	Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p [Source:SGD;Acc:S000006293]	biological_process	Golgi apparatus, cellular_component	molecular_function, protein binding		
YPR091C	YPR091C	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene [Source:SGD;Acc:S000006295]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, ribosome	molecular_function, protein binding		
YPR092W	YPR092W	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006296]					
YPR093C	ASR1	Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein [Source:SGD;Acc:S000006297]	protein ubiquitination, response to ethanol	cytoplasm, nucleus	metal ion binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding		
YPR094W	RDS3	Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance [Source:SGD;Acc:S000006298]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome, response to xenobiotic stimulus, spliceosome assembly	U2 snRNP, nucleus, spliceosomal complex	molecular_function		
YPR095C	SYT1	Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain [Source:SGD;Acc:S000006299]	exocytosis, positive regulation of ARF protein signal transduction, regulation of ARF protein signal transduction, vesicle-mediated transport	Golgi apparatus part, cytoplasm, intracellular, mitochondrion	ARF guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity, protein binding		
YPR096C	YPR096C	Protein of unknown function that may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000006300]	biological_process	ribosome	molecular_function		
YPR097W	YPR097W	Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000006301]	biological_process, cell communication	membrane, mitochondrial membrane, mitochondrion	phosphatidylinositol binding		
YPR098C	YPR098C	Protein of unknown function, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000006302]	biological_process	integral to membrane, membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YPR099C	YPR099C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W [Source:SGD;Acc:S000006303]					
YPR100W	MRPL51	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000006304]	aerobic respiration, mitochondrial translation	mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YPR101W	SNT309	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p [Source:SGD;Acc:S000006305]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	Prp19 complex, U2-type catalytic step 1 spliceosome, nucleus, spliceosomal complex	first spliceosomal transesterification activity		
YPR102C	RPL11A	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11 [Source:SGD;Acc:S000006306]	ribosomal large subunit assembly, translation	cytoplasm, cytosolic large ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome	RNA binding, rRNA binding, structural constituent of ribosome		
YPR103W	PRE2	Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome [Source:SGD;Acc:S000006307]	proteasomal ubiquitin-dependent protein catabolic process, proteasomal ubiquitin-independent protein catabolic process, proteasome core complex assembly, proteolysis involved in cellular protein catabolic process	cytoplasm, endoplasmic reticulum membrane, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex, proteasome storage granule	endopeptidase activity, hydrolase activity, peptidase activity, threonine-type endopeptidase activity		
YPR104C	FHL1	Regulator of ribosomal protein transcription; has forkhead associated domain that binds phosphorylated proteins; also has forkhead DNA-binding domain but does not bind DNA in vitro; suppresses RNA pol III and splicing factor prp4 mutants [Source:SGD;Acc:S000006308]	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter, positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent	CURI complex, nuclear chromatin, nucleolus, nucleus	DNA binding, protein binding, repressing transcription factor binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, transcription factor binding		
YPR105C	COG4	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000006309]	CVT pathway, intra-Golgi vesicle-mediated transport, macroautophagy, peroxisome degradation, protein transport, retrograde transport, vesicle recycling within Golgi, transport	Golgi apparatus, Golgi membrane, Golgi transport complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane	molecular_function		
YPR106W	ISR1	Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C [Source:SGD;Acc:S000006310]	biological_process, protein phosphorylation	cellular_component	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPR107C	YTH1	Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation [Source:SGD;Acc:S000006311]	mRNA cleavage, mRNA polyadenylation, mRNA processing	mRNA cleavage and polyadenylation specificity factor complex, nucleus	RNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YPR108W	RPN7	Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits [Source:SGD;Acc:S000006312]	ubiquitin-dependent protein catabolic process	nucleus, proteasome complex, proteasome regulatory particle, lid subcomplex	binding, protein binding, structural molecule activity		
YPR108W-A	YPR108W-A	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028590]	biological_process	cellular_component	molecular_function		
YPR109W	YPR109W	Predicted membrane protein; dipoid deletion strain has high budding index [Source:SGD;Acc:S000006313]	biological_process, cell cycle	cellular_component, integral to membrane, membrane	molecular_function		
YPR110C	RPC40	RNA polymerase subunit AC40, common to RNA polymerase I and III [Source:SGD;Acc:S000006314]	tRNA transcription from RNA polymerase III promoter, transcription from RNA polymerase I promoter	DNA-directed RNA polymerase I complex, DNA-directed RNA polymerase III complex, nucleolus, nucleus	DNA binding, DNA-directed RNA polymerase activity, protein dimerization activity		
YPR111W	DBF20	Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis [Source:SGD;Acc:S000006315]	cell cycle, protein phosphorylation	cytoplasm	ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPR112C	MRD1	Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains [Source:SGD;Acc:S000006316]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, small-subunit processome assembly	90S preribosome, nucleolus, nucleus, ribonucleoprotein complex	RNA binding, molecular_function, nucleic acid binding, nucleotide binding		
YPR113W	PIS1	Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins [Source:SGD;Acc:S000006317]	phosphatidylinositol biosynthetic process, phospholipid biosynthetic process	Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome, mitochondrial outer membrane, mitochondrion	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity, phosphotransferase activity, for other substituted phosphate groups, transferase activity		
YPR114W	YPR114W	Putative protein of unknown function [Source:SGD;Acc:S000006318]	biological_process	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane	molecular_function		
YPR115W	RGC1	Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator; paralogous to Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000006319]	cell cycle, positive regulation of glycerol transport	cytoplasm	molecular_function, protein binding		
YPR116W	RRG8	Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport [Source:SGD;Acc:S000006320]	mitochondrial genome maintenance	mitochondrion	molecular_function		
YPR117W	YPR117W	Putative protein of unknown function [Source:SGD;Acc:S000006321]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YPR118W	MRI1	5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway [Source:SGD;Acc:S000006322]	L-methionine salvage from methylthioadenosine, cellular amino acid biosynthetic process, cellular biosynthetic process, cellular metabolic process, methionine biosynthetic process	cytoplasm, nucleus	S-methyl-5-thioribose-1-phosphate isomerase activity, isomerase activity		
YPR119W	CLB2	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome [Source:SGD;Acc:S000006323]	G2/M transition of mitotic cell cycle, cell cycle, cell division, mitosis, positive regulation of spindle pole body separation, regulation of cyclin-dependent protein kinase activity	cellular bud neck, cytoplasm, nucleus, spindle, spindle pole body	cyclin-dependent protein kinase regulator activity		
YPR120C	CLB5	B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase [Source:SGD;Acc:S000006324]	G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, cell cycle, cell division, positive regulation of DNA replication, positive regulation of spindle pole body separation, premeiotic DNA replication, regulation of S phase of mitotic cell cycle, regulation of cyclin-dependent protein kinase activity, spindle assembly	nucleus	cyclin-dependent protein kinase regulator activity		
YPR121W	THI22	Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis [Source:SGD;Acc:S000006325]	thiamine biosynthetic process	cellular_component, extracellular region	phosphomethylpyrimidine kinase activity		
YPR122W	AXL1	Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells [Source:SGD;Acc:S000006326]	axial cellular bud site selection, peptide pheromone maturation, proteolysis	cellular bud neck, mating projection tip, peripheral to membrane of membrane fraction	catalytic activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding		
YPR123C	YPR123C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR [Source:SGD;Acc:S000006327]					
YPR124W	CTR1	High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels [Source:SGD;Acc:S000006328]	copper ion import, copper ion transport, ion transport, transport	integral to membrane, membrane, membrane fraction, plasma membrane	copper ion transmembrane transporter activity, copper uptake transmembrane transporter activity		
YPR125W	YLH47	Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome [Source:SGD;Acc:S000006329]	potassium ion transport, protein insertion into mitochondrial membrane, proton transport	integral to membrane, membrane, mitochondrial inner membrane, mitochondrion	molecular_function		
YPR126C	YPR126C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006330]					
YPR127W	YPR127W	Protein of unknown function, differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000006331]	biological_process, oxidation-reduction process	cytoplasm, nucleus	molecular_function, oxidoreductase activity, pyridoxine:NADP 4-dehydrogenase activity		
YPR128C	ANT1	Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation [Source:SGD;Acc:S000006332]	ATP transport, fatty acid beta-oxidation, ion transport, peroxisome organization, proton transport, transmembrane transport, transport	cytoplasm, integral to membrane, integral to peroxisomal membrane, membrane, peroxisomal membrane, peroxisome	adenine nucleotide transmembrane transporter activity, binding		
YPR129W	SCD6	Protein containing an Lsm domain; negatively regulates translation initiation via 48S preinitiation complex assembly; may bind RNA and have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1 [Source:SGD;Acc:S000006333]	RNA metabolic process, formation of translation preinitiation complex, negative regulation of translational initiation	cytoplasm	RNA binding		
YPR130C	YPR130C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006334]					
YPR131C	NAT3	Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met [Source:SGD;Acc:S000006335]	N-terminal peptidyl-methionine acetylation, cytoskeleton organization, metabolic process, mitochondrion inheritance	NatB complex, cytoplasm	N-acetyltransferase activity, acyltransferase activity, peptide alpha-N-acetyltransferase activity, transferase activity		
YPR132W	RPS23B	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal [Source:SGD;Acc:S000006336]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), regulation of translational fidelity, translation	cytoplasm, cytosolic small ribosomal subunit, intracellular, ribonucleoprotein complex, ribosome, small ribosomal subunit	structural constituent of ribosome		
YPR133C	SPN1	Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype [Source:SGD;Acc:S000006337]	regulation of transcription, DNA-dependent, transcription elongation from RNA polymerase II promoter, transcription elongation, DNA-dependent	nucleus, transcription elongation factor complex	DNA binding, translation elongation factor activity		
YPR133W-A	TOM5	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore [Source:SGD;Acc:S000006433]	protein targeting to mitochondrion, protein transport, transport	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrial outer membrane translocase complex, mitochondrion	protein channel activity		
YPR134W	MSS18	Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions [Source:SGD;Acc:S000006338]	Group I intron splicing, RNA splicing, mRNA processing	mitochondrion	molecular_function		
YPR135W	CTF4	Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion [Source:SGD;Acc:S000006339]	DNA repair, DNA replication, DNA-dependent DNA replication, double-strand break repair via break-induced replication, mitotic sister chromatid cohesion, replicative cell aging	nuclear chromosome, nuclear replication fork, nucleus, replication fork protection complex	DNA binding, chromatin binding, protein binding		
YPR136C	YPR136C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9 [Source:SGD;Acc:S000006340]					
YPR137C-A	YPR137C-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007359]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YPR137C-B	YPR137C-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007360]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YPR137W	RRP9	Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein [Source:SGD;Acc:S000006341]	rRNA modification, rRNA processing, ribosome biogenesis	90S preribosome, box C/D snoRNP complex, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	protein binding, snoRNA binding		
YPR138C	MEP3	Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease [Source:SGD;Acc:S000006342]	ammonium transport, nitrogen utilization, transmembrane transport, transport	integral to membrane, membrane, plasma membrane	ammonium transmembrane transporter activity		
YPR139C	VPS66	Cytoplasmic protein of unknown function involved in vacuolar protein sorting. [Source:SGD;Acc:S000006343]	protein targeting to vacuole, protein transport, transport	cytoplasm, integral to membrane, membrane	molecular_function		
YPR140W	TAZ1	Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome [Source:SGD;Acc:S000006344]	cardiolipin metabolic process, inner mitochondrial membrane organization, metabolic process, mitochondrial ATP synthesis coupled electron transport, phospholipid biosynthetic process, protein complex assembly	integral to membrane, integral to mitochondrial outer membrane, membrane, mitochondrial outer membrane, mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity, acyltransferase activity, transferase activity		
YPR141C	KAR3	Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate [Source:SGD;Acc:S000006345]	cell cycle, cell division, karyogamy, karyogamy involved in conjugation with cellular fusion, meiosis, microtubule-based movement, mitosis, mitotic sister chromatid cohesion, nuclear migration involved in conjugation with cellular fusion	cytoplasm, cytoplasmic microtubule, cytoskeleton, microtubule, nucleus, spindle pole body	ATP binding, microtubule motor activity, minus-end-directed microtubule motor activity, motor activity, nucleotide binding, protein heterodimerization activity		
YPR142C	YPR142C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing [Source:SGD;Acc:S000006346]					
YPR143W	RRP15	Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs [Source:SGD;Acc:S000006347]	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosome biogenesis	nucleolus, nucleus, preribosome, large subunit precursor	molecular_function		
YPR144C	NOC4	Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits [Source:SGD;Acc:S000006348]	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis	90S preribosome, Noc4p-Nop14p complex, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome	molecular_function		
YPR145C-A	YPR145C-A	Putative protein of unknown function [Source:SGD;Acc:S000113589]	biological_process	cellular_component	molecular_function		
YPR145W	ASN1	Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway [Source:SGD;Acc:S000006349]	asparagine biosynthetic process, cellular amino acid biosynthetic process, glutamine metabolic process	cytoplasm	ATP binding, asparagine synthase (glutamine-hydrolyzing) activity, ligase activity, nucleotide binding		
YPR146C	YPR146C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006350]					
YPR147C	YPR147C	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000006351]	biological_process	cytoplasm, integral to membrane, membrane	molecular_function		
YPR148C	YPR148C	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000006352]	biological_process	cytoplasm, ribosome	molecular_function		
YPR149W	NCE102	Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs) [Source:SGD;Acc:S000006353]	eisosome assembly, establishment of protein localization in plasma membrane, negative regulation of protein phosphorylation, plasma membrane organization, protein secretion, protein transport, transport	cellular bud membrane, cytoplasm, endoplasmic reticulum, integral to membrane, mating projection membrane, membrane, membrane fraction, membrane raft, mitochondrion, plasma membrane, plasma membrane enriched fraction	molecular_function		
YPR150W	YPR150W	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C [Source:SGD;Acc:S000006354]					
YPR151C	SUE1	Mitochondrial protein required for degradation of unstable forms of cytochrome c [Source:SGD;Acc:S000006355]	protein catabolic process	mitochondrial envelope, mitochondrion	molecular_function		
YPR152C	URN1	Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase [Source:SGD;Acc:S000006356]	RNA splicing, biological_process, mRNA processing	nucleus, spliceosomal complex	molecular_function, protein binding		
YPR153W	YPR153W	Putative protein of unknown function [Source:SGD;Acc:S000006357]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YPR154W	PIN3	Protein that induces appearance of [PIN+] prion when overproduced [Source:SGD;Acc:S000006358]	actin cytoskeleton organization	cytoplasm, nucleus	molecular_function, protein binding		
YPR155C	NCA2	Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p [Source:SGD;Acc:S000006359]	aerobic respiration, mRNA metabolic process	integral to membrane, membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion	molecular_function		
YPR156C	TPO3	Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily [Source:SGD;Acc:S000006360]	spermine transport, transmembrane transport, transport	integral to membrane, membrane, membrane fraction, plasma membrane, vacuolar membrane	antiporter activity, spermine transmembrane transporter activity		
YPR157W	YPR157W	Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000006361]	biological_process, protein transport, transport	cellular_component, integral to membrane, membrane	molecular_function		
YPR158C-C	YPR158C-C	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007361]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YPR158C-D	YPR158C-D	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007362]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YPR158W	CUR1	Protein of unknown function involved in destabilization of [URE3] prions; similar in sequence to Btn2p [Source:SGD;Acc:S000006362]	biological_process	nucleus	molecular_function		
YPR158W-A	YPR158W-A	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007363]	transposition, RNA-mediated	cytoplasm, retrotransposon nucleocapsid	RNA binding		
YPR158W-B	YPR158W-B	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007364]	DNA integration, DNA recombination, proteolysis, transposition, transposition, RNA-mediated, viral procapsid maturation	cytoplasm, nucleus, retrotransposon nucleocapsid	ATP binding, DNA binding, DNA-directed DNA polymerase activity, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, catalytic activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, peptidase activity, ribonuclease H activity, ribonuclease activity, transferase activity		
YPR159C-A	YPR159C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028725]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YPR159W	KRE6	Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p [Source:SGD;Acc:S000006363]	1,6-beta-glucan biosynthetic process, cellular cell wall organization, fungal-type cell wall organization	Golgi apparatus, Golgi membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane, plasma membrane, site of polarized growth, transport vesicle	glucosidase activity		
YPR160C-A	YPR160C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028726]					
YPR160W	GPH1	Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway [Source:SGD;Acc:S000006364]	carbohydrate metabolic process, glycogen catabolic process, glycogen metabolic process	cytoplasm	glycogen phosphorylase activity, phosphorylase activity, pyridoxal phosphate binding, transferase activity, transferase activity, transferring glycosyl groups		
YPR160W-A	YPR160W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028860]					
YPR161C	SGV1	Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p [Source:SGD;Acc:S000006365]	phosphorylation of RNA polymerase II C-terminal domain, positive regulation of histone H3-K4 methylation, protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex, nucleus	ATP binding, RNA polymerase II carboxy-terminal domain kinase activity, cyclin-dependent protein kinase activity, kinase activity, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity		
YPR162C	ORC4	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing [Source:SGD;Acc:S000006366]	DNA replication, DNA-dependent DNA replication initiation, chromatin silencing at silent mating-type cassette, pre-replicative complex assembly	DNA replication preinitiation complex, nuclear origin of replication recognition complex, nucleus, origin recognition complex, pre-replicative complex	DNA binding, DNA replication origin binding		
YPR163C	TIF3	Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA [Source:SGD;Acc:S000006367]	translation, translational initiation	ribosome	RNA binding, RNA strand annealing activity, nucleic acid binding, nucleotide binding, translation initiation factor activity		
YPR164W	MMS1	Subunit of an E3 ubiquitin ligase complex involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay [Source:SGD;Acc:S000006368]	DNA repair, negative regulation of transposition, RNA-mediated, nonfunctional rRNA decay, recombinational repair, replication fork processing, response to DNA damage stimulus	Cul8-RING ubiquitin ligase complex, nucleus	molecular_function		
YPR165W	RHO1	GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) [Source:SGD;Acc:S000006369]	actin cytoskeleton organization, actin cytoskeleton reorganization, budding cell bud growth, positive regulation of endocytosis, positive regulation of protein kinase C signaling cascade, regulation of cell size, regulation of exocyst localization, regulation of fungal-type cell wall 1,3-alpha-glucan biosynthetic process, regulation of fungal-type cell wall organization, regulation of protein localization, regulation of vacuole fusion, non-autophagic, small GTPase mediated signal transduction	1,3-beta-D-glucan synthase complex, Golgi apparatus, cellular bud neck, cellular bud tip, endosome, endosome membrane, incipient cellular bud site, intracellular, mating projection tip, membrane, membrane fraction, mitochondrial outer membrane, mitochondrion, peroxisomal membrane, peroxisome, plasma membrane, plasma membrane enriched fraction	GTP binding, GTPase activity, nucleotide binding, signal transducer activity		
YPR166C	MRP2	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000006370]	mitochondrial translation, translation	intracellular, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome	structural constituent of ribosome		
YPR167C	MET16	3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism [Source:SGD;Acc:S000006371]	cellular amino acid biosynthetic process, cysteine biosynthetic process, metabolic process, methionine biosynthetic process, methionine metabolic process, oxidation-reduction process, sulfate assimilation, sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)	cytoplasm, intracellular	oxidoreductase activity, phosphoadenylyl-sulfate reductase (thioredoxin) activity, transferase activity		
YPR168W	NUT2	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription [Source:SGD;Acc:S000006372]	regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter	mediator complex, nucleus			
YPR169W	JIP5	Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein [Source:SGD;Acc:S000006373]	ribosomal large subunit biogenesis	nucleolus, nucleus	molecular_function, protein binding		
YPR169W-A	YPR169W-A	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B [Source:SGD;Acc:S000028591]					
YPR170C	YPR170C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B [Source:SGD;Acc:S000006374]					
YPR170W-A	YPR170W-A	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028861]					
YPR170W-B	YPR170W-B	Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C [Source:SGD;Acc:S000028515]	biological_process	cellular_component, integral to membrane, membrane	molecular_function		
YPR171W	BSP1	Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton [Source:SGD;Acc:S000006375]	actin cortical patch localization, endocytosis	actin cortical patch, cellular bud neck, cellular bud tip, cytoplasm, cytoskeleton, mating projection tip, membrane, membrane fraction, plasma membrane	protein binding, bridging		
YPR172W	YPR172W	Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance [Source:SGD;Acc:S000006376]	biological_process	cytoplasm, nucleus	FMN binding, molecular_function		
YPR173C	VPS4	AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism [Source:SGD;Acc:S000006377]	intralumenal vesicle formation, late endosome to vacuole transport, late endosome to vacuole transport via multivesicular body sorting pathway, protein homooligomerization, protein retention in Golgi apparatus, protein transport, sterol metabolic process, transport	cytoplasm, endoplasmic reticulum, endosome, endosome membrane, membrane, soluble fraction	ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding, protein homodimerization activity		
YPR174C	YPR174C	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate [Source:SGD;Acc:S000006378]	biological_process	cytoplasm, cytoskeleton, membrane, nuclear envelope, nuclear membrane, nucleus, spindle pole body	molecular_function		
YPR175W	DPB2	Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate [Source:SGD;Acc:S000006379]	DNA replication, cell cycle, lagging strand elongation, leading strand elongation, mismatch repair, nucleotide-excision repair	cytoplasm, epsilon DNA polymerase complex, nucleus, replication fork	DNA binding, DNA-directed DNA polymerase activity, double-stranded DNA binding, nucleotidyltransferase activity, transferase activity		
YPR176C	BET2	Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p [Source:SGD;Acc:S000006380]	ER to Golgi vesicle-mediated transport, protein geranylgeranylation, protein targeting to membrane	Rab-protein geranylgeranyltransferase complex	Rab geranylgeranyltransferase activity, catalytic activity, metal ion binding, prenyltransferase activity, transferase activity		
YPR177C	YPR177C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex [Source:SGD;Acc:S000006381]					
YPR178W	PRP4	Splicing factor, component of the U4/U6-U5 snRNP complex [Source:SGD;Acc:S000006382]	RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U4/U6 x U5 tri-snRNP complex, nucleus	molecular_function, protein binding		
YPR179C	HDA3	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p [Source:SGD;Acc:S000006383]	chromatin modification, chromosome segregation, gene silencing by RNA, gene silencing involved in chronological cell aging, histone deacetylation, negative regulation of transcription from RNA polymerase II promoter	HDA1 complex, nucleus	DNA binding, chromatin binding, histone deacetylase activity		
YPR180W	AOS1	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability [Source:SGD;Acc:S000006384]	metabolic process, protein sumoylation, response to DNA damage stimulus	SUMO activating enzyme complex, nucleus	SUMO activating enzyme activity, binding, catalytic activity		
YPR181C	SEC23	GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport [Source:SGD;Acc:S000006385]	ER to Golgi vesicle-mediated transport, intracellular protein transport, protein transport, regulation of COPII vesicle coating, transport, vesicle-mediated transport	COPII vesicle coat, ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, membrane	GTPase activator activity, metal ion binding, protein binding, zinc ion binding		
YPR182W	SMX3	Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F [Source:SGD;Acc:S000006386]	RNA processing, RNA splicing, mRNA processing, nuclear mRNA splicing, via spliceosome	U1 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, nucleus, ribonucleoprotein complex	RNA binding, molecular_function		
YPR183W	DPM1	Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation [Source:SGD;Acc:S000006387]	GPI anchor biosynthetic process, protein N-linked glycosylation, protein O-linked glycosylation	endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, mitochondrial outer membrane, mitochondrion, nuclear outer membrane-endoplasmic reticulum membrane network	dolichyl-phosphate beta-D-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups		
YPR184W	GDB1	Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria [Source:SGD;Acc:S000006388]	carbohydrate metabolic process, glycogen biosynthetic process, glycogen catabolic process, metabolic process	cytoplasm, mitochondrion	4-alpha-glucanotransferase activity, amylo-alpha-1,6-glucosidase activity, catalytic activity, cation binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, transferase activity, transferase activity, transferring glycosyl groups		
YPR185W	ATG13	Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling [Source:SGD;Acc:S000006389]	CVT pathway, activation of protein kinase activity, autophagy, macroautophagy, mitochondrion degradation, piecemeal microautophagy of nucleus, protein transport, transport	Atg1p signaling complex, cytoplasm, extrinsic to membrane, membrane	protein kinase regulator activity		
YPR186C	PZF1	Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA [Source:SGD;Acc:S000006390]	5S class rRNA transcription from RNA polymerase III type 1 promoter	intracellular, nucleus	5S rDNA binding, DNA binding, RNA binding, metal ion binding, nucleic acid binding, zinc ion binding		
YPR187W	RPO26	RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit [Source:SGD;Acc:S000006391]	tRNA transcription from RNA polymerase III promoter, transcription from RNA polymerase I promoter, transcription from RNA polymerase II promoter, transcription from RNA polymerase III promoter, transcription, DNA-dependent	DNA-directed RNA polymerase I complex, DNA-directed RNA polymerase II, core complex, DNA-directed RNA polymerase III complex, RNA polymerase complex, cytoplasm, nucleus	DNA binding, DNA-directed RNA polymerase activity		
YPR188C	MLC2	Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring [Source:SGD;Acc:S000006392]	cell cycle, cell division, contractile ring contraction involved in cell cycle cytokinesis	cellular bud neck, cellular bud neck contractile ring, myosin complex	calcium ion binding, motor activity, myosin II binding		
YPR189W	SKI3	Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay [Source:SGD;Acc:S000006393]	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5', nuclear-transcribed mRNA catabolic process, non-stop decay, response to virus	Ski complex, cytoplasm, nucleus	binding, molecular_function, protein binding		
YPR190C	RPC82	RNA polymerase III subunit C82 [Source:SGD;Acc:S000006394]	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase III complex, cytoplasm, nucleus	DNA binding, DNA-directed RNA polymerase activity		
YPR191W	QCR2	Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme [Source:SGD;Acc:S000006395]	aerobic respiration, electron transport chain, mitochondrial electron transport, ubiquinol to cytochrome c, proteolysis, transport	membrane, mitochondrial inner membrane, mitochondrial respiratory chain complex III, mitochondrion, respiratory chain	catalytic activity, metal ion binding, metalloendopeptidase activity, ubiquinol-cytochrome-c reductase activity, zinc ion binding		
YPR192W	AQY1	Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance [Source:SGD;Acc:S000006396]	ascospore formation, transmembrane transport, transport, water transport	integral to membrane, membrane, plasma membrane	transporter activity, water channel activity		
YPR193C	HPA2	Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity [Source:SGD;Acc:S000006397]	chromatin modification, histone acetylation, metabolic process, protein homotetramerization	cytoplasm	N-acetyltransferase activity, acyltransferase activity, histone acetyltransferase activity, protein homodimerization activity, transferase activity		
YPR194C	OPT2	Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles [Source:SGD;Acc:S000006398]	oligopeptide transport, peptide transport, protein transport, transmembrane transport, transport, vacuole fusion, non-autophagic	integral to membrane, integral to plasma membrane, membrane	oligopeptide transporter activity		
YPR195C	YPR195C	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006399]					
YPR196W	YPR196W	Putative maltose activator [Source:SGD;Acc:S000006400]	biological_process, regulation of transcription, DNA-dependent	cellular_component, nucleus	DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, zinc ion binding		
YPR197C	YPR197C	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006401]					
YPR198W	SGE1	Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations [Source:SGD;Acc:S000006402]	drug transport, response to drug, transmembrane transport, transport	integral to membrane, integral to plasma membrane, membrane	drug transmembrane transporter activity		
YPR199C	ARR1	Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds [Source:SGD;Acc:S000006403]	positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to arsenic-containing substance	cytoplasm, nucleus	DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity		
YPR200C	ARR2	Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p [Source:SGD;Acc:S000006404]	response to arsenic-containing substance	cellular_component	arsenate reductase activity		
YPR201W	ARR3	Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite [Source:SGD;Acc:S000006405]	antimonite transport, arsenite transport, response to arsenic-containing substance, sodium ion transport, transport	integral to membrane, membrane, plasma membrane	antimonite transmembrane transporter activity, arsenite transmembrane transporter activity, bile acid:sodium symporter activity		
YPR202W	YPR202W	Putative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo [Source:SGD;Acc:S000006406]	biological_process	cellular_component	molecular_function		
YPR203W	YPR203W	Putative protein of unknown function [Source:SGD;Acc:S000006407]	biological_process	cellular_component	molecular_function		
YPR204C-A	YPR204C-A	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028727]					
YPR204W	YPR204W	Helicase-like protein encoded within the telomeric Y' element [Source:SGD;Acc:S000006408]	biological_process	cellular_component	ATP binding, ATP-dependent helicase activity, DNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding		
